Kim Solez, MD

>66% of global health burden is made up of chronic non-communicable diseases, depression, diabetes, heart disease, stroke, cancer, kidney disease, hypertension.

Life style risk factors of smoking, obesity, inactivity. Need more educational emphasis on life style diseases, healthy aging.

Diseases lead to organ failure. Transplanted organs are available for fewer than 10% of people who need them.

New technologies, stem cell creation of organs, xenotransplantation, and bio-artificial organs, will be able to reach 10-100 fold more people than transplantation reaches today. Exponential change, change occurring at faster and faster rate, not linear.

The technological singularity occurs as artificial intelligences surpass human beings as the smartest and most capable life forms on the Earth. Technological development is taken over by the machines, who can think, act and communicate so quickly that normal humans cannot even comprehend what is going on. The machines enter into a "runaway reaction" of self-improvement cycles, with each new generation of A.I.s appearing faster and faster. From this point onwards, technological advancement is explosive, under the control of the machines, and thus cannot be accurately predicted (hence the term "Singularity"). – Ray Kurzweil

All natural disease may be eliminated, leaving

only man-made diseases. But that may leave

as much for physicians to do as there is today!

Challenging responses to bioterrorism and

stem cell technologies.

Focus of medicine no longer disease but

enhancement, elevating the human condition,

which will extend beyond the physical to the

moral and spiritual.

Social responsibility an important aspect of

medicine and one of the focuses of the course.

“It is the curse of humanity that it learns to tolerate even the most horrible situations by habituation. Physicians are the natural attorneys of the poor, and the social problems should largely be solved by them.”-Rudolf Virchow

“Medicine is a social science, and politics is nothing else than medicine writ large. Medicine as a social science, as the science of human beings, has the obligations to point out problems and to attempt their theoretical solution: the politician, the practical anthropologist, must find the means for their practical solution.”

– Rudolf Virchow

Assume the primacy of global health!

Telemedicine and “doctor in your cell phone” main uses of technology!

Ten minute introduction

Fifty minute lecture

Twenty minute discussion

In the course we talk about machines replacing many of the functions of human beings. This picture was taken by a machine without human intervention, as were many of the best still images from the course. The video camera is constantly comparing the scene to algorithms and takes still pictures when the requirements of the interesting picture algorithm are satisfied.

First teaching session 2011 Recent teaching session 2014

Hot-linked tables of contents in YouTube video descriptions at

http://www.youtube.com/user/kimsolez allow one

to jump right to content of interest.

Director of Social Media at Kandu Inc.

We shoot broadcast quality video of each lecture & discussion. http://www.singularitycourse.com

Previous lectures at http://www.youtube.com/user/KimSolez . Students critique one past lecture, and suggest improvements in presentation and hot-linked table of contents (20% of grade).

Students write one 3,000 word paper (40%) and give 20 min. presentation on same subject (30%). Also graded on class participation (10%).

No required reading. Suggested reading list in course outline, readings suggested by Email.

The technological Singularity. Existential

risks, AI, genomics, and nanotech.

Ways to optimize a positive outcome for

humanity in the co-evolution of humans

and machines . The influence of these

considerations on medicine of the future .

Dean of Science speaking, prominent

people internationally. Most lectures not

very “medical”. Easily understood.

Balanced view provided by incorporating

both tech skeptics and tech advocates .

New Medical School

Devoted to Rural

Health, Patan

Academy of Health

Sciences, Annual

Consultative Meeting

2011, Nagarkot,

Nepal

Medical student elective participation in course.

International peer review of YouTube videos, modifications made. Two Quantum Biology lectures.

Young person old person point counterpoint lecture January 30th, Abdullah Saleh/Earle Waugh Medical Ethics in a World of Robots(What will we allow when everything is possible).

Collaboration with Disruptive Technologies in Medicine course in Budapest, Hungary, the only other course somewhat like this one.

Student feedback extremely positive in Fall 2014, all 5’s!

Flipped classroom sessions with well know people by Skype.

Melbourne, Sydney, Hong Kong, Berkeley, Edmonton,

Houston, Hawaii, Sao Paulo, Thanksgiving Point, Utah,

Brussels, Paris, LA, Palo Alto, Washington, Carlton,

Australia, Wroclaw, Poland

Run like Autodesk Design Night.

Best. Salon. Ever. March 1, 2016.

Hosted by media professional

Dr. Julielynn Wong of Singularity U.

Analogous to Paris Salon of a

century ago which moved Western

thought and culture forward, music,

art, good conversation, something unique,

innovative, and memorable!

Mature youthful decision making!

You can do it!

InternetEvolution.com “ThinkerNet Blog” had essays written criticizing Ray Kurzweilby people who had never read any of his books.

And people criticizing Peter Diamandis’ Abundance by people who had never read the book.

Frustrating. What is the worst you can imagine happening in this circumstance?

Histologic criteria for the diagnosis of rejection and other

conditions in the transplanted kidney, began 1991, updated

and expanded every two years in consensus meeting.

Banff Transplant

Pathology Meetings

Began in the

Transcanada Pipelines

Pavilion at the Banff

Centre in 1991, Future

Meetings Are Planned

through 2021.

To introduce you to the basic elements of artificial intelligence, machine learning, and data mining.

To introduce you to basic concepts of the influence of artificial intelligence on the exponential future, including the concept of unfriendly AI, and the technological Singularity.

To provide you with concrete examples of AI in everyday life and in medicine.

The Technological

Singularity

There were YouTube videos (now removed) suggesting that stem cell generation of complex organs in humans would be routine by 2020. Problems of clotting, endothelial loss, and cell type selection errors not mentioned.

The dramatic slowdown of new drug approvals (Eroom’sLaw) by the FDA suggests that the FDA is ripe for disruptive innovation. Has happened.

However stem cell therapies may be the last area the FDA will relax regulation in, as unproven bogus stem cell therapies are causing widespread suffering and protection of the general public is needed.

The recellularized organ clots like crazy, impossible to regenerate more than 80% of endothelial surface. Artificial heparized surface not fenestrated. Cell traffic abnormal.

Hard to get right types of cells to right places.

Podocytes seems to be terminally differentiated cells, when attempt to culture they turn into different type of cell.

Kidney progenitor stem cell difficult to identify, kidney work has lagged behind.

Easy to make stem cell generated kidneys that lack loop of Henle. Could produce lethal polyuria. What is “function”?

Many old fashioned questions of physiology about how the stem cell generated organ works, not just true for kidney, true for every organ.

Stem cell generated organs, xenografts, and bioartificialorgans can be combined.

Transplant pathologists will also become tissue engineering pathologists, pathologists who analyse organs grown from stem cells. This is not something beyond us, we can adapt to a work life that includes stem cells.. Someone needs to cross the disciplines,

Many of the questions that need to be posed about stem cell generated organs are old fashioned questions, intact nephron hypothesis, cell regeneration, stunned myocardium, contraction band necrosis etc. Use your nostalgia! Stimulate conversations between stem cell researchers and transplant physicians.

Robots will not be completely autonomous, just as we are not completely autonomous.

They will need things from us. People they can trust will have high status in society. It

will start with human decisions about who to offer intelligence enhancing brain implants

to, which people to make into cyborgs. In the best case those decisions are made on the

basis of optimizing benefit to society and the world. There will be a new job of learning

how to help robots, as they harmoniously coevolve with humans.

The image of the death of Roy Batty in Blade Runner and the “tears in rain” speech will

become the background of our thinking about our responsibilities to robots. We have a

responsibility to keep them alive once they have memories like we do, a sense of self,

and live “lives with meaning”, which benefit society and the world. Robot human

relationships will be a subject studied in school, the basis for a new human profession of

robot liaison. If all goes well this will be one the most respected human professions.

The climax of the classic Sci-fi film "Blade Runner”.

Roy Batty (1:48):

"I've seen things you people wouldn't believe.] Attack ships on fire off the shoulder of Orion. I watched c-beams glitter in the dark near the Tannhäuser Gate. All those moments will be lost in time, like [coughs] tears in rain. Time to die.”

http://youtu.be/NoAzpa1x7jU

Nova program on PBS Television (7 million viewers)

Big Bang Theory (the TV show; 20 million viewers)

Singularity Summit/Singularity 1on1 (9,000 views per video)

Kim Solez – Technology and Future of Medicine Course LABMP 590 (2,800 views per video)

We need the mainstream public to regard the Singularity as fact, not fiction.

We need to promote organized thinking about the future in Universities and beyond.

We need to make efforts to make Singularitianismaccessible and inclusive, with low barrier to entry, incorporating young people, and balanced views/diversity. “The Singularity for Dummies!” Assume global health is primary link with the Singularity.

UP UNTIL SHORTLY BEFORE HIS DEATH AT 72, ISAAC ASIMOV REFERRED TO HIMSELF AS BEING “IN MY LATE YOUTH”.

A SIMILAR SITUATION FACES ALL OF US BUT THE “YOUTH” WILL CONTINUE WELL BEYOND AGE 72 AND ENHANCED COMMUNICATIONS BROUGHT ABOUT BY TECHNOLOGY WILL BE AN IMPORTANT PART OF WHAT SUSTAINS IT!

In many areas of importance in the future, the boundaries, the limits you may be thinking of may not exist.

Are there video documentaries about the Technological Singularity?

What about doing a video series on all sorts of different possible future outcome scenarios?

Do you really believe that machines will become smarter than human beings?

Is it possible that organ donation will increase to the point where all the need for transplanted organs is satisfied?

My course schedule will not allow me to take your course. Could you create a podcast so it can be experienced remotely?