kicking the whale

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A short story in powerpoint format by flash fiction writer david gaffneywww.davidgaffney.org

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  • 1. Smell P172 whimpers saliva CBS CBS CBS CBS Moans Lick velocity (Glucose transporter 4) Lick pressure (Phosphofructokinase} Penetration depth (Insulin Receptorsubstrate 1) Lick oscilation (Nitric oxide synthase) Action Lick frequency (Glycogen synthase) Angle of approach Director position development opportunity Tongue

2. Genetic factors in early-onset AD 40 17 (688) -secretase (BACE) DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV EVKMTVIVITLVML D AEFRHDSGYEVHHQK L VFFAEDVGSNKGAIIGLMVGGVV IA -Amyloid aggregates 1 (672) 770aa Kunitz domain -amyloid peptide Extracellular Domain APP mutants: Total 25 -secretase Nicastrin Presenilin-1/2 APH1 PEN2 TVIVITLVML DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV IA 42 DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA PS1: >160 mutants PS2: 10 mutants APPmRNA AAAAA AAAAA APPmRNA APPpromoter mutants APPgene duplication 3. -secretase Nicastrin Presenilin-1/2 APH1 PEN2 TVIVITLVML DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV IA 42 DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA PS1: >160 mutants PS2: 10 mutants 4. Phosphatidylcholine synthesis Choline kinase Phosphocholine Choline Phosphocholine cytidylyltransferase Phosphatidic acid phosphatase Acyl CoA synthase Glycerol-3-Phosphate acyltransferase Acyl glycerol-3-Phosphate acyltransferase Diacylglycerol phosphocholine transferase Phosphatidylcholine 5. IKK IKK IKK IKK p52 AAAAA NFkB p50 NFkB p65 CRE ATF P P P P p100 P p52 JNK Fra1 PU.1 P P MafB Runx2 ER E 2 P IKK Hsp90 P cdc37 P Cbl PTEN Ras Raf GAB2 Sos Grb2 RANKLRANKLRANK Motif 1 Motif 2 Motif 3 RANK Motif 1 Motif 2 Motif 3 RANK Motif 1 Motif 2 Motif 3 TAB2 P TAK1 P P Tpl2 NIK Src TRAF6 TRAF6 RANKLPI3K Limd1 MEKK3 S526 TAB1 P OPG PDK JAK-1 STAT1 INF R1 Box INF R1 Y466 Y466 S727 Y701 Y701 Y701 Y701 Smad 2 TGF RII Kinase TGF RI Kinase TGF RII Kinase TGF RIKinase S465 S467 Smad 3 S422 S424 GS T204 TGF RANK, MEKK3, RIPK,IFN , NFATc1, IL1 , IL18, Bcl-2 , Cathepsin K, TRAP CBP p38 NFkB p50 NFkB p65 I B S32 S36 NFkB p65 NFkB p65 NFkB p65 Mek 1/2 Fos NFATc1 Ca Ca Ca Ca Ca Mitf PKB STAT2 JAK-2 Box STAT2 STAT1 STAT2 STAT1 Y701 Y701 Smad 3 Smad 4 Smad 2 P P P Smad 3 Smad 4 Smad 2 P P P STAT2 STAT1 Y701 Y701 INF ER E 2 E 2 6. Kicking the whale Phosphatidylcholine 7. The options were clear.Id set them out on a PowerPoint slide. 8. Plastic tongues Rubber tongues 9. Third party Manual Like that. Easy .Smad 3 Smad 4 Smad 2 P P P E 2 10. The government representatives, the regional development agency, the international nuclear bodies But everyone in the conference room was laughing.Smad 2 TGF RII Kinase TGF RI Kinase TGF RII Kinase TGF RIKinase S465 S467 Smad 3 S422 S424 GS T204 TGF 11. Colin Rushford red-faced sweating TVIVITLVML All in fits of hilarity 42 me from the stage PS1: >160 mutants PS2: 10 mutants frantically tried to remove my slides from the screen and Futures Nuclear and the Executive Director of 12. to give me the job of head of internal communications The aim of my post was simple. in the workplace. All staff will display respectful behaviour I was to achieve this with a PowerPoint Presentation. Yet my prowess at PowerPointpresentationspersuaded Nuclear Futures 13. APPmRNA APPmRNA The future of theUK nuclear industryWas in my hands No pressure then AAAAA AAAAA 14. Smell P172 whimpers saliva CBS CBS CBS CBS Moans Lick velocity (Glucose transporter 4) Lick pressure (Phosphofructokinase} Penetration depth (Insulin Receptorsubstrate 1) Lick oscilation (Nitric oxide synthase) Action Lick frequency (Glycogen synthase) Angle of approach Director position development opportunity tongue 15. Smell P172 whimpers saliva CBS CBS CBS CBS Moans Lick velocity (Glucose transporter 4) Lick pressure (Phosphofructokinase} Penetration depth (Insulin Receptorsubstrate 1) Lick oscilation (Nitric oxide synthase) Tongue action Lick frequency (Glycogen synthase) Angle of approach Director position development opportunity Tongue 16. Smell P172 whimpers saliva CBS CBS CBS CBS Moans Lick velocity (Glucose transporter 4) Lick pressure (Phosphofructokinase} Penetration depth (Insulin Receptorsubstrate 1) Lick oscilation (Nitric oxide synthase) Tongue action Lick frequency (Glycogen synthase) Angle of approach Director position development opportunity Tongue 17. The conference was in a country hotel.The conference was in a posh hotel Nice food, pleasant meeting rooms,and a disco so you could strut about to Come on Eileen with the off duty waitresses 18. Colin gave me some examples of the problems Nuclear Futures would like me to address. Tongues TONGUES Tongues 19. A pond containing highly-active spent rods began leaking in 1974 and the press had found out.It was too dangerous for divers, so there was nothing we could do other than to peer in through the eye of a robot and sigh. 20. Another problem was biscuits.At an internal meeting Colin had been served bourbons from a tin of Family Choice.Nuclear Futures must employ directional biscuits, he explained 21. Staff had been heard in the canteen making fun of the leaking pond, and of the new procurement rules for biscuits, especially the paragraph on home-baked versus home-baked-look Staff must be taught to respect the management team and the management teams decisions 22. The options were clear. The presentation I produced addressed these problems 23. Plastic tongues Rubber tongues 24. Third party Manual Like that. Easy .Smad 3 Smad 4 Smad 2 P P P E 2 25. All presented in a neat PowerPoint package.In hindsight I dont think Nuclear Futures were ready for irony because Colin was furious, and when the laughter died away, the nuclear industry funders, customers and decision makers were shaking their heads. 17 (688) Nuclear futures Tongues tongues tongues tongues 1 (672) Kunitz domain -amyloid peptide Extracellular Domain 26. Re-enchantment To re-imagine the future,Mathew In my briefing Colin had explained that the nuclear industry needed 27. People stopped imagining the future after the 1950s.Now, even the turbochoads in off-road sandals are saying nuclear power is good.The future hasnt moved on. JAK-1 STAT1 STAT2 INF R1 Box JAK-2 INF R1 Box Y466 Y466 Y701 Y701 INF 28. APPmRNA APPmRNA Thats the pig in the pythonNuclear power with meer-cats and Jools HollandPopular up there AAAAA AAAAA 29. Smell P172 whimpers saliva CBS CBS CBS CBS Moans Lick velocity (Glucose transporter 4) Lick pressure (Phosphofructokinase} Penetration depth (Insulin Receptorsubstrate 1) Lick oscilation (Nitric oxide synthase) Action Lick frequency (Glycogen synthase) Angle of approach Director position development opportunity tongue 30. Smell P172 whimpers saliva CBS CBS CBS CBS Moans Lick velocity (Glucose transporter 4) Lick pressure (Phosphofructokinase} Penetration depth (Insulin Receptorsubstrate 1) Lick oscilation (Nitric oxide synthase) Tongue action Lick frequency (Glycogen synthase) Angle of approach Director position development opportunity Tongue 31. Smell P172 whimpers saliva CBS CBS CBS CBS Moans Lick velocity (Glucose transporter 4) Lick pressure (Phosphofructokinase} Penetration depth (Insulin Receptorsubstrate 1) Lick oscilation (Nitric oxide synthase) Tongue action Lick frequency (Glycogen synthase) Angle of approach Director position development opportunity Tongue 32. might be the wolf nearest the sledge but we need to speak Our enemies are all around us to all wolves everywhere Our own staff. But were just kicking dead whales down the beach The lefty press .. 33. The conference was in a country hotel.I suggested that staff may needmore development opportunities. The problem is, Mathew,our staff havetoo manyskills. 34. the billionpound Reprocessing contract Y701we lost Thats why STAT2 STAT1 another. Staff with Japan knew how to cut and paste from one excel spreadsheet to 35. high-level skills and self-motivation.staff with We dont want our downfall carbo Triglicerides andMalonyl-CoAThats been (PPAR coactivator) 36. APPmRNA APPmRNA We need strategies to de-skill our staff strategies to de-skill our staff staff our staff to de-skill our staff AAAAA AAAAA 37. constantly working at the outer edge of their abilities. 17 (688) make them feelworthless, ignorant, EVKMTVIVITLVML complicated, impossible tasks1 (672) APP mutants: Total 25 TVIVITLVML Make them feel out of their depth,and their roles seem pointless, so nothing makes sense.Give them as if they are 38. Take us on a journey to hopelessness.Did you know, Mathew, that in the old days subordinates used to salute senior staff in the corridors?Even serve food in the canteen?Ahopelessworkforce shows respect.JAK-1 STAT1 STAT2 INF R1 Box JAK-2 INF R1 Box Y466 Y466 Y701 Y701 INF 39. Smell P172 whimpers saliva CBS CBS CBS CBS Moans Lick velocity (Glucose transporter 4) Lick pressure (Phosphofructokinase} Penetration depth (Insulin Receptorsubstrate 1) Lick oscilation (Nitric oxide synthase) Action Lick frequency (Glycogen synthase) Angle of approach Director position development opportunity tongue 40. Smell P172 whimpers saliva CBS CBS CBS CBS Moans Lick velocity (Glucose transporter 4) Lick pressure (Phosphofructokinase} Penetration depth (Insulin Receptorsubstrate 1) Lick oscilation (Nitric oxide synthase) Tongue action Lick frequency (Glycogen synthase) Angle of approach Director position development opportunity Tongue 41. Smell P172 whimpers saliva CBS CBS CBS CBS Moans Lick velocity (Glucose transporter 4) Lick pressure (Phosphofructokinase} Penetration depth (Insulin Receptorsubstrate 1) Lick oscilation (Nitric oxide synthase) Tongue action Lick frequency (Glycogen synthase) Angle of approach Director position development opportunity Tongue 42. The nagging piano riff of New York, New York drifted up from the bar, and I imagined Colin and the senior management linking arms and kicking their legs.I looked at the PowerPoint template, the oblong gaping for its heading, the box below aching for pin-sharp bullet points. Tongues TONGUES Tongues 43. I