kenneth e. mccarson, ph.d.wichita.kumc.edu/documents/pharmacology/faculty/mc... · therapeutics...

Kenneth E. McCarson, Ph.D. Curriculum Vitae

July, 2015 Title: Professor with Tenure

Office Address: Department of Pharmacology, Toxicology, and Therapeutics The University of Kansas Medical Center 3901 Rainbow Boulevard, MSN 1018 2069 Hemenway Life Sciences Innovation Center Kansas City, KS 66160

Office Telephone: (913) 588-7519 (2069 Hemenway) Laboratory phone: (913) 588-7595 (2054 Hemenway) Telephone FAX: (913) 588-7501 Home Telephone: (816) 523-0664 E-mail: [email protected] Website: http://www.kumc.edu/school-of-medicine/pharmacology-toxicology-and-therapeutics/faculty/kenneth-e-mccarson-phd.html EDUCATION & TRAINING

Primary School: The Westminster Schools, Atlanta, Georgia; 9/67 - 6/80

Undergraduate: Georgia Institute of Technology, Atlanta, Georgia; 6/80 - 6/84 Bachelor of Chemical Engineering (B.Ch.E.) awarded 6/84 Major: Chemical Engineering Minor: Biopsychology (Program certification awarded 6/84)

Graduate: Medical College of Georgia, Augusta, Georgia; 9/85 - 5/91 Ph.D. in Pharmacology awarded with distinction 5/91 (Major Advisor: Barry D. Goldstein, Ph.D.) Dissertation Title: Regulation of Substance P Levels and Release in the Dorsal Horn During Nociception PROFESSIONAL EXPERIENCE

Current (6/2015 - ) Professor of Pharmacology with Tenure Department of Pharmacology, Toxicology, and Therapeutics The University of Kansas School of Medicine, Kansas City, Kansas

6/2001 – 5/2015 Associate Professor of Pharmacology with Tenure Department of Pharmacology, Toxicology, and Therapeutics The University of Kansas School of Medicine, Kansas City, Kansas

7/2009 - Present Co-Director, Biobehavioral Measurement Core (BMC) of the Kansas Intellectual and Developmental Disabilities Research Center (KIDDRC). The University of Kansas Medical Center Kansas City, Kansas

6/2003 – Present Director, Rodent Behavior Facility R. L. Smith Intellectual and Developmental Disabilities Research Center (IDDRC) The University of Kansas Medical Center Kansas City, Kansas

mailto:[email protected]

http://www.kumc.edu/school-of-medicine/pharmacology-toxicology-and

Kenneth E. McCarson, Ph.D. Curriculum Vitae - page 2

3/2010 - Present Faculty Member, Institute for Neurological Disorders (IND) Women’s Pain Division, Neurodegenerative Disorders Division The University of Kansas Medical Center Kansas City, Kansas

6/2000 – 6/2008, Director, Department Graduate Training Program (Co-Director 2012 - ) 6/2012 -present Department of Pharmacology, Toxicology and Therapeutics (two graduate degree programs: 1.Pharmacology, 2.Toxicology)

5/2000 – present Faculty Member R. L. Smith Kansas Intellectual and Developmental Disabilities Research Center (KIDDRC), The University of Kansas Medical Center, Kansas City, Kansas [formerly the Kansas Mental Retardation and Developmental Disabilities Research Center]

6/1995 – 5/2001 Assistant Professor of Pharmacology Department of Pharmacology, Toxicology, and Therapeutics The University of Kansas School of Medicine Kansas City, Kansas

6/1991 – 6/1995 Postdoctoral Research Associate in Neurobiology (Supervisor: James E. Krause, Ph.D.; Professor of Neurobiology) Washington University School of Medicine St. Louis, Missouri

9/1985 – 5/1991 Graduate Research Assistant (Supervisor: Barry D. Goldstein, Ph.D., Professor of Pharmacology) Medical College of Georgia Augusta, Georgia PROFESSIONAL TRAINING (Received): The Faculty Leadership Academy, 2012 - 2014 The Advisory Board Academies (ABA), Washington, DC Program includes eight half-day sessions on: Leading Change, Optimizing Core Processes, Foundations of Finance, Breakthrough Negotiation, Strategic Goal Alignment, Instilling Cost Discipline, The Quest for Quality, Leading Change, and Managing Disruptive Behavior GRANT AWARDS (Research, Equipment and Teaching – direct costs)

2015 – 2017 Smith, Peter G (PI) NIH R21 GM114647 $300,000 Role of a BHLHB9 polymorphism in the etiology of a developmental disorder McCarson, K.E. - 10% Salary Support as Co-Investigator

2015 McCarson, K.E. (PI) Kansas IDeA Network of Biomedical Research Excellence (K-INBRE) Administrative Core Facility Support Award $15,500 Rodent Behavior Facility Equipment Acquisition

2014 - 2019 Carlsten Christianson, J.A. (PI) NIH R01 DK099611 $1,250,000 Effect of Neonatal and Adult Stress on Pelvic Pain Disorders and Comorbidity McCarson, K.E. - 5% Salary Support as Co-Investigator


2014 - 2019 Carlsten Christianson, J.A. (PI) NIH R01 DK103872 $1,250,000 Comorbid mood and urogenital disorders in mice following neonatal maternal separation McCarson, K.E. - 5% Salary Support as Co-Investigator

2014 - 2015 McCarson, K.E. (PI) KU Medical Alumni Innovative Teaching Fund Award $15,000 An interactive, animated simulation for enhanced teaching of Autonomic Pharmacology concepts

2014 Smith, Peter G (PI) P30 HD002528 Supplement (NICHD) $129,000 Undiagnosed Disease Program (UDP) UDP3404 Supplemental Funds McCarson, K.E. - 6% Salary Support as RBF Director, and BMC Co-Director

2013 – 2015 Taylor, BK (PI) University of Kentucky Chandler Medical Center [NIH] R01 NS045954 $50,000 Neuropeptidergic Inhibition of Spinal Pain Transmission McCarson, K.E. - Subcontract PI

2011 – 2016 Smith, Peter G, Nudo, Randolph (PIs) Ronald D. Deffenbaugh Foundation Spinal Cord Injury Repair Program $6,800,000 McCarson, K.E. - 20% Salary Support plus $110K annual research budget as SCI Outcomes Assessment Project Director

2011 – 2016 Smith, Peter G (PI) Kansas Intellectual & Developmental Disabilities Research Center (KIDDRC) NIH P30 HD002528-48 $2,230,510 McCarson, K.E. - RBF Director, BMC Co-Director (13%)

2012 – 2017 Smith, Peter G (PI) NIH R01 HD049615 $1,652,080 Identifying Therapeutic Targets in Vulvodynia McCarson, K.E. - 5% Salary Support as Co-Investigator

2013 – 2014 Levine, Stephen E (PI) RG4720A7/2 $81,518 National Multiple Sclerosis Society ( Pathogenic implications of cerebrovascular changes in a cerebral model of multiple sclerosis McCarson, K.E. - 3% Salary Support as Co-Investigator

2012 – 2013 Kingsmore, Stephen (Co-PI); Smith, Peter G. (Co-PI) Patton Trust Development Grant, Kansas City Area Life Sciences Institute (KCALSI) $19,998 Discovery and validation of novel Mendelian disease genes for childhood diseases McCarson, K.E. - 5% Salary Support as Co-Investigator

2012 – 2014 Berman, Nancy E (PI) Lied Basic Science Pilot Grant $25,000 Mechanism of Sex Differences in Migraine McCarson, K.E. - 5% Salary Support as Co-Investigator

2010 Sharma, N, (PI) American Physical Therapy Assoc. Res. Grant $40,000 Cortical Changes Following Exercise Training in Chronic Low Back Pain McCarson, K.E. - Co-Mentor

2010 – 2011 Bradley K. Taylor (PI) University of Kentucky Chandler Medical Center NIH NINDS 2 R01 NS045954 $21,875 Neuropeptidergic Inhibition of Spinal Pain Transmission


McCarson, K.E. - Subcontract PI

2010 – 2011 Sharma, Neena K (PI) KUMC Research Institute Inc. (Bridging) $25,000 Exercise Induced Neural Changes in People with Chronic Low Back Pain: A Pilot Study McCarson, K.E. - Co-Mentor

2009 – 2013 Berman, N.E. (PI) Merck & Company, Inc.; Research Grant $73,287 Can Telcagepant Prevent or Improve Transformed Migraine? McCarson, K.E. - 5% Salary Support as Co-Investigator

2008 – 2009 Berman, N.E. (PI) Merck & Company, Inc.; Research Grant $59,154 CGRP and Peripheral Sensitization in a Rat Behavioral Model of Migraine McCarson, K.E. - 5% Salary Support as Co-Investigator

2008 Bradley K. Taylor (PI) Tulane University 2 R01 NS045954 $21,875 Neuropeptidergic Inhibition of Spinal Pain Transmission McCarson, K.E. - Subcontract PI

2008 – 2009 Berman, N.E. (PI) American Headache Society – Pfizer $34,783 A Rodent Behavioral Model of Menstrual Migraine McCarson, K.E. - 5% Salary Support as Co-Investigator

2008 – 2009 Berman, N.E. (PI) Migraine Research Foundation $45,455 A Behavioral Model of Menstrual Migraine McCarson, K.E. - 5% Salary Support as Co-Investigator

2006 – 2009 McCarson, K.E. (PI) National Alliance for Research on Schizophrenia and Depression (NARSAD) Independent Investigator Award $92,592 Chronic Pain Activates Mechanisms of Depression

2006 – 2011 Klaassen CD (PI) NIH 5 T32 ES007079 $1,361,680 Training Program in Environmental Toxicology McCarson, K.E. – Faculty Mentor

2011 – 2016 Smith, Peter G (PI) Kansas Intellectual & Developmental Disabilities Research Center (KIDDRC) NIH P30 HD002528-44 $2,460,027 McCarson, K.E. - RBF Director (10%)

2007 – 2008 McCarson, K.E. (PI) Kansas IDeA Network of Biomedical Research Excellence (K-INBRE) Bridging Grant Award $35,000 CNS Sites Where Estrogen Modulates Hyperalgesia

2007 – 2008 McCarson, K.E. (PI) Kansas IDeA Network of Biomedical Research Excellence (K-INBRE) Administrative Core Facility Support Award $17,500 Rodent Behavior Facility Research Staff Support

2006 - 2008 Enna, S.J. (PI) University of Nebraska Medical Center [Proctor & Gamble Company] CK#16323926 $37,000 Antinociceptive Properties of Alpha2-Adrenoceptor Agonists McCarson, K.E. - Co-PI

2006 – 2007 McCarson, K.E. (PI) KUEA - Ernst N. Lied Foundation Pilot Research Grant $35,000 Chronic Pain Activates Mechanisms of Depression


2005 – 2010 Dileepan, Kottarappat N (PI) NIH R01 HL070101 $1,188,074 Mast Cell-Induced Inflammation in Vascular Disease McCarson, K.E. - 5% Salary Support as Co-Investigator

2005 – 2010 Smith, Peter G (PI) NIH NICHD 1R01HD049615 $1,125,000 Female Pelvic Pain, Hormones, and Neuroplasticity McCarson, K.E. - 5% Salary Support as Co-Investigator

2004 – 2007 Levant B (PI) NIH 1 R01 MH071599 $475,000 Brain LC-PUFA’s & Maternal Mental Health McCarson, K.E. - 10% Salary Support as Co-Investigator

2004 – 2005 McCarson, K.E., Smith Peter G (Co-PIs) Kansas IDeA Network of Biomedical Research Excellence (K-INBRE) Administrative Core Facility $35,000 Rodent Behavior Facility Research Staff Support

2005 – 2012 Toews, M (PI) NIH NIGMS R-25 GM074089 $1,531,191 Short Course: Integrative and Organ Systems Pharmacology McCarson, K.E. - Instructor for “Fundamentals of somatic sensation”, “Pharmacological regulation of pain sensation”; “Evaluation of analgesic drugs: Spontaneous behaviors” (laboratory)”

2003 – 2005 Enna, SJ (PI) KUEA - Ernst N. Lied Foundation Pilot Research $33,343 Pharmacology of Neuropathic McCarson, K.E. - Co-PI

2003 – 2004 Levant, Beth (PI) Kansas Univ Medical Center (K-BRIN Grant) $70,000 Neural Nechanisms of Restless Legs in a Rodent Model McCarson, K.E. - 10% Salary Support as Co-Investigator

2003 McCarson, K.E. and Peter G. Smith (Co-PIs) University of Kansas Medical Center Research Institute Shared Research Equipment Award $25,000 Multi-User Rodent Behavioral Test System (RBF Equipment - Colburn activity monitors and Rota-Rod)

2003- 2004 McCarson, K.E. (PI) KUEA - Ernst N. Lied Foundation Pilot Research Grant $35,000 Effect of Topical Morphine Analgesia on Cutaneous Wound Healing

2001 – 2009 McCarson, K.E. (PI) American Society for Pharmacology and Experimental Therapeutics (ASPET) Institutional Summer Undergraduate Research Fellowship Program Grant $81,000 McCarson, K.E. - Program Director

2001 – 2006 Smith, Peter G (PI) Kansas Intellectual & Developmental Disabilities Research Center (KIDDRC) NIH P30 HD002528-38 $750,000 McCarson, K.E. - RBF Director (10%)

The Kansas IDDRC is provides multi-campus core support to externally funded investigators conducting projects relevant to intellectual and developmental disabilities, and includes 4 cores supporting 4 research themes comprising approximately 80 investigators and 100 funded projects.

2000 – 2007 McCarson, K.E. (PI) NIH NIDA 1R01DA12505 $1,150,000 Nociceptive Sensory Regulation of Neurokinin Receptor Function


1999 – 2003 Long, Teresa D. (PI) NIH 1 R01 AR45506 $358,423 Morphine Gel for Pressure Ulcer Analgesia McCarson, K.E. - 5% Salary support as Co-Investigator

1998 – 2003 McCarson, K.E. (PI) University of Kansas Medical Center Research Institute, Inc.; Bridging Grant $25,000 Neurokinin Receptor Function During Nociception

1998 – 2000 McCarson, K.E. (PI) KUEA - Ernst N. Lied Foundation Pilot Research Grant $50,000 Molecular mechanisms underlying sex differences in chronic pain

1997 – 1999 McCarson, K.E. (PI) American Heart Association Heartland Beginning Grant-In-Aid KS-97-GB-70 $50,000 Tachykinin Plasticity During Chronic Inflammation and Cardiac Pain

1996 McCarson, K.E. (PI) Whitehall Foundation Grant-In-Aid #FA96-06 $15,000 Neurokinin Receptor Function During Nociception

1992 – 1994 McCarson, K.E. (PI) NIH F32 DE54782 $52,000 Individual Postdoctoral Training Award (Sponsor: James E. Krause, Ph.D.) Nociceptive Regulation of Tachykinin Receptor Function

1991 – 1992 Sanes, Joshua (PI) NIH 5-T32-NS07071 $750,000 Cellular and Molecular Neurobiology Departmental Training Award Washington University Department of Anatomy and Neurobiology McCarson, K.E. - 100% Salary support as postdoctoral trainee PROFESSIONAL SOCIETY AND ORGANIZATION MEMBERSHIPS Sigma Xi (Secretary, KUMC Chapter, 2001 – 2005) Society for Neuroscience (Secretary/Treasurer, KUMC Chapter, 2004 – 2007; Steering Committee, KUMC Chapter, 2011 - present) American Association for the Advancement of Science (1987 – present) American Society for Pharmacology and Experimental Therapeutics (1995 – present) Division for Pharmacology Education (Primary affiliation) Division for Neuropharmacology Division for Behavioral Pharmacology American Pain Society (1995 - present) Midwest Pain Interest Group (1997 - present) HONORS AND AWARDS KU Chancellor’s Distinguished Teaching Award, 2014 KUMC Academy of Medical Educators International Association of Medical Science Educators (IAMSE) Travel Award, June, 2014 The Faculty Leadership Academy, 2012 Faculty Travel Scholarship Award, KUMC School of Graduate Studies, 2011 Faculty Travel Scholarship Award, KUMC School of Graduate Studies, 2006 Marquis Who’s Who in Science and Engineering, 2005-2006 (8th Edition) Faculty Travel Scholarship Award, KUMC School of Graduate Studies, 1998 Faculty International Travel Award, KUMC School of Graduate Studies, 1998 Faculty Travel Scholarship Award, KUMC School of Graduate Studies, 1997


Faculty Travel Scholarship Award, KUMC School of Graduate Studies, 1996 Sigma Xi Student Research Paper Award, Honorable Mention, 1990 Who’s Who Among Students in American Universities and Colleges, 1989 IMHOTEP Leadership Honorary Society, 1989 Medical College of Georgia Faculty Wives Scholarship, 1989 Medical College of Georgia GSRD Award for Excellence in Research, 1988 United States Achievement Academy Scholastic All-American, 1987 National Merit Scholarship, 1980-1984 INVITED SEMINARS / SYMPOSIA PRESENTATIONS

Institute for Neurological Disorders, University of Kansas Medical Center Translational Discovery Forum “Gene variant discovery in developmental disorders: from child to gene to mouse to drug to child”, December 2013 Des Moines University, Des Moines, IA Research Seminar Series, “Can a Rat Tell You She has a Headache? There’s More to Pain than Molecular Signaling” September, 2013 Kansas Medical Education Foundation Topeka, KS Combined Grand Rounds “Sex and Pain”, September 2012 University of Kansas Medical Center, Department of Molecular and Integrative Physiology “Can a Rat Tell You She Has a Headache? There's More to Pain than Molecular Signaling”, April 2012 Institute for Neurological Disorders, University of Kansas Medical Center Translational Discovery Forum “Vitamin D, migraine, and related pain disorders”, October 2010 University of Kentucky College of Medicine Department of Physiology, February 2010 University of Kansas Medical Center Molecular and Integrative Physiology, October 2007 American Pain Society Annual Meeting Washington, D.C., May 2007 Symposium Chairman and presenter, “Persistent Pain, the Hippocampus, and Depression – Mechanistic Links?” Rockhurst University, Kansas City, MO Pre-Med Student Association, April 2007 Cold Spring Harbor Laboratory - Banbury Center Conference “Molecular Approaches to Pain: Translational Potential and Challenges” Cold Spring Harbor, NY, April 2007. Spring Pain Research Conference Grand Cayman, BWI, April 2006 Co-Chairman (With Richard Traub) of “Sex Differences and Pain” symposium University of Kansas, Lawrence, KS American Institute of Chemical Engineering, Student Chapter, April 2006 University of Texas Health Sciences Center, San Antonio TX Department of Endodontics, April 2005 University of Kansas Medical Center


Smith MRRC and Women in Medicine and Neuroscience Mini-Symposium “Female Pain Syndromes: Basic Science Perspectives”, January 2005 Society for Neuroscience Annual Meeting New Orleans, LA, November 2003 Chairman of plenary (slide) session #657 “Nociception” Spring Pain Research Conference Grand Cayman, BWI, May 2004 University of Kansas Medical Center Molecular and Integrative Physiology, February 2004 Northeastern Ohio Universities College of Medicine, Rootstown OH Department of Neurobiology, December 2003 University of Kansas Medical Center Neuroscience Program Mental Retardation and Developmental Disabilities Research Center, May 2003 Benedictine University, Atchison, Kansas Department of Biological Sciences, October 2001 21st Winter Neuropeptide Conference Breckenridge, Colorado, U.S.A. January 2000 Millennium Pharmaceuticals, Inc. Cambridge, MS, June 1999 University of Kansas Medical Center Center on Aging, May 1999 University of Missouri, Kansas City School of Pharmacy, Pharmacology Division, May 1999 Spring Pain Research Conference Grand Cayman, BWI, May 1998 University of Kansas Medical Center Department of Physiology, 1997 University of Missouri, Kansas City School of Pharmacy, Pharmacology Division, 1996 University of Kansas Medical Center Sigma Xi Local Chapter, 1996 Mercer University School of Medicine Division of Basic Medical Sciences, 1995 University of Kansas Medical Center Department of Pharmacology, Toxicology, and Therapeutics, 1995 University of North Carolina at Chapel Hill Department of Physiology, Chapel Hill, North Carolina, 1990 Washington University School of Medicine Department of Anatomy and Neurobiology, St. Louis, Missouri, 1990 Uniformed Services University of the Health Sciences Department of Pharmacology, Bethesda, Maryland, 1990 TEACHING ACTIVITIES

Educational Leadership: 2000 - 2008 Director of Departmental Graduate Training Program (~ 25 Pharmacology, Toxicology PhD Students/yr) 2012 - present Co-Director of Departmental Graduate Training Program (~ 31 Pharmacology, Toxicology PhD Students/yr)


2001 - 2008 Director, Departmental American Society for Pharmacology and Experimental Therapeutics [ASPET] Summer Undergraduate Research Fellowship Program

Pharmacological Basis of Therapeutics (PHCL 888/PHRM 850), MS2, [1998 – 2007], and Medical Core Curriculum “Integration and Consolidation” (Core 860) MS2, 2008 – 2014: Autonomic Pharmacology Block Leader 1998 – present Autacoid Pharmacology Block Leader, 2008 – present (In these courses, a course block leader serves as a course sub-director to manage instructors across a section of the course [e.g., neuro, cardiovascular -, autacoid] “blocks” of the course).

Courses:

Molecular and Cellular Pharmacology and Toxicology PHCL/PTOX 841: Course Block Captain (Lecture & test organization) for Pharmacodynamics lectures, 1996 – 1999

Molecular and Cellular Pharmacology and Toxicology PHCL/PTOX 742: Course Block Captain (Independent Study leadership) for Autonomic Pharmacology, 2000

Seminar in Pharmacology PHCL 809 (Graduate Student Seminar series): Course Director (Instruction, evaluation, and scheduling), 2011 - present

Essentials of Pharmacology PHCL/PTOX 880 (Lecture & test organization): Course Director (Instruction, evaluation, and scheduling), 2012 – present

KUMC Interdisciplinary Graduate Program in the Biomedical Sciences (IGPBS): Module 4: Cell & Developmental Biology IGPBS 894 Course Co-Director, 2005 – 2007 Director, Signal Transduction section, 2007 - 2009 Module 4C of the IGPBS: Signal Transduction GSMC 855: Course Director, 2009

Instruction:

Medical: (Selected as the 2014 recipient of the KU Chancellor’s Distinguished Teaching Award)

University of Kansas Medical Center:

Pharmacological Basis of Therapeutics PHCL 888/PHRM 850 (Year 2) Autonomic nervous system; cholinergic and adrenergic drugs Narcotics; opioid drugs and analgesia Class lectures (1997 - 2007) and small group discussions (1996 - 2007)

Medical Neuroscience ANAT/PHSL 840 (Year 1) Somatic sensation and pain (1997 - 2006)

(KUMC Medical curriculum revised to Organ-Based Modules in 2007)

Medical Core Curriculum “Musculoskeletal and Soft Tissue” (Core 835) Year 2 Lecture entitled “Pharmacology of Rheumatic Disease” (2008 - present)

Medical Core Curriculum “Brain and Behavior” (Core 840) Year 2 Lectures entitled “Somatosensory Receptors”, “Somatic sensation” and “Pain 1”


(2007 - present); “CNS Neurotransmitters” (2011 - present); Pharmacology of the Eye (2012 - present)

Medical Core Curriculum “Integration and Consolidation” (Core 860) Year 2 Lectures entitled “Autonomic Nervous System Principles”; “Cholinergic Receptor

Agonists”, “Cholinergic Receptor Antagonists”, “Adrenergic Receptor Agonists”, “Adrenergic Receptor Antagonists”, and “Vasoactive Peptides” (2008 - present);

Lectures entitled “Histamine, Serotonin, & Ergot Alkaloids“, “Prostaglandins, Leukotrienes and Non-Steroidal Anti-Inflammatory Drugs (NSAIDS)”, “Treatment of Asthma”, “ (2008 - present); “Treatment of Arthritis”, “Treatment of Allergies and Migraine”, and “Drugs Used to Treat Gastrointestinal Disorders”, (2012 - present)

Large Group discussion presenter/facilitator: “ANS Simulation”, (2014 - present)

Small Group discussion facilitator: “ANS and Smooth Muscles” (2008 - 2013), “Cardiovascular”, “Endocrine”, “CNS”, “Adverse Drug Effects” (2008 - present), “General Principles and Asthma” (2014 - present)

Pain & Its Management, PSY 838 (Rehabilitation Medicine Residents) Physiological mechanisms of Pain (2002 - 2005)

Medical College of Georgia:

Medical Pharmacology Phase II Laboratory Demonstrations: Autonomic and CNS Drugs (1987 - 1990)

Undergraduate: Medical College of Georgia: School of Allied Health; Introduction to Pharmacology Drug Therapy of Parkinsonism & Other Basal Ganglia Disorders (1988 - 1991)

Graduate:

University of Kansas Medical Center (Departmental):

Seminar in Pharmacology PHCL 809 (Graduate Student Seminar series) Course Director (Instruction, evaluation, and scheduling) (2011 - present)

Molecular and Cellular Pharmacology and Toxicology PHCL/PTOX 841 Course Block Captain (Lecture & test organization) Quantitation of receptor occupation and response lectures (1996 - 1999)

Molecular and Cellular Pharmacology and Toxicology PHCL/PTOX 742 Course Block Captain (Independent Study leadership) Autonomic Pharmacology (2000)

Essentials of Pharmacology PHCL/PTOX 880 (Lecture & test organization) Autonomic Pharmacology (2000 - present) Neuropharmacology Principles, Analgesics & Local Anesthetics (2004 - present) Case discussions – Block I (ANS and CNS, 2008 - present) and Block II (Cardiovascular and Endocrine Pharmacology, 2014 - present)

Course Director (Instruction, evaluation, and scheduling) (2012 – present)

Essentials of Toxicology PHCL/PTOX 917 (Lecture & test organization)


Neurotoxicology (2013 - present)

Neuropharmacology PHCL 912 Transcription factors, receptor cloning, peptide neuropharmacology. (2000)

Neuropharmacology PHCL 941 Peptide neuropharmacology (1998)

University of Kansas Medical Center (Extra-departmental):

Advanced Neuroscience ANAT/PHSL/PHCL 846 Somatic sensation, pain, and peptide neurotransmitters (1997 - 1998) Neuropharmacology laboratory sessions (1998 - 2006) Mechanisms of Pain and Analgesia (2007 – present) Autonomic Pharmacology (2010)

Pathobiology of Human Function II REHS 863 Basic Neurobiology: Studies addressing the co-morbidity of pain and major depression (2009 - 2013)

Advanced Studies in Rehabilitation Science REHS 962 Pain Pathways and the intersection between chronic pain and major depression (2010 - 2013)

Health and Social Behavior, HPM 858 (Health Policy and Mgt. MHSA students) The Neurobiology of Placebo: Insights From a Pain Neurobiologist’s

Perspective (2011 - 2012)

University of Kansas Medical Center Interdisciplinary Graduate Program in the Biomedical Sciences (IGPBS):

Module 1: Thermodynamics, Protein Structure, and Analysis of Reaction/ Binding kinetics IGPBS 891 Characterization of receptor binding I & II (1997 - 2000)

Module 4: Cell & Developmental Biology IGPBS 894 (Course Co-Director, 2005 – 2007; Director, Signal Transduction section, 2007 - 2009) Graphical methods quantifying receptor function and cellular, system, or organismal responsiveness (2002 - 2009) (Module 4 split into separate courses in 2009)

Module 4C of the IGPBS: Signal Transduction GSMC 855

(Course Director, 2009)

Module 6: Molecular and Physiological Basis of Disease I IGPBS 896 Somatosensory pathways and multiple sclerosis (1998)

External Teaching: NIGMS Short Course: Integrative and Organ Systems Pharmacology http://www.unmc.edu/dept/iosp/ Course Co-Instructor (2004 - 2012) Lectures: Fundamentals of somatic sensation; Pharmacological regulation of pain Sensation; Laboratory Exercise : Evaluation of analgesic drugs

http://www.unmc.edu/dept/iosp/


STUDENT ADVISING

Ph.D. Dissertations Directed:

Heather Amthauer, IGPBS student rotation, spring 1998; Graduate trainee 1998 - 1999 Project: Regulation of neurokinin receptor expression during nociception by baclofen

Amy Allen, IGPBS student rotation, fall 2000; Graduate trainee 2000 - 2005; Projects: Regulation of NK-1 receptor expression in mouse; Gender influences on pain Ph.D. Dissertation title: “Estrogen Modulates Brain-Derived Neurotrophic Factor and the Neurokinin-1 Receptor During Inflammatory Nociception” Defended Ph.D. in Pharmacology with honors, 4/14/2005 (KUMC Student Travel Awards, 2000-2004; Currently Sr. Medical Science Liaison II at Shire Pharmaceuticals, Denver)

Vanja Duric, IGPBS student rotation, spring 2001; Graduate trainee 2000 - 2005; Projects: Regulation of G-protein function by substance P 1-7; Effects of chronic pain on hippocampal morphology and function Ph.D. Dissertation title: “Spinal and Limbic Plasticity in the Rat During Inflammatory Nociception and Immobilization Stress” Defended Ph.D. in Pharmacology with honors, 12/23/2005 (KUMC Student Travel Awards, 2002- 2005; KUMC Biomedical Research Training Program Award, 2003-2005; Postdoc at Yale Dept. Mol. Psychiatry; Currently Assistant Professor at Des Moines University)

Jerri Rook, IGPBS student rotation, fall 2003; Graduate trainee 2004 - 2008 Ph.D. Dissertation title: “Mechanisms of Cutaneous Wound Healing are Mediated by Peripheral Neuropeptide Activity” Defended Ph.D. in Pharmacology 05/05/2008 (1st place 2006 Graduate Student Research Forum Award; KUMC Student Travel Awards, 2005- 2007; KUMC Biomedical Research Training Program Award, 2006-2007; Currently Research Assistant Professor of Pharmacology at Vanderbilt University Medical Center

Andrew Ralya, IGPBS student rotation, spring 2005, Graduate trainee 2005 - 2010 Ph.D. Dissertation title: “Sex Steroids Modulate Nociception, and Estrogen Modifies Supraspinal Nociceptive Activation” Defended Ph.D. in Pharmacology 12/14/2010 (KUMC Student Travel Award, 2006, 2007 & 2008; KUMC Biomedical Research Training Program Award, 2009-10; Currently Clinical Pharmacology Research Fellow, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota)

Nicholas Stucky, Anatomy MD/PhD student, Graduate trainee 2007 - 2010 (Co-Major Advisor with Nancy Berman, Ph.D.) Ph.D. Dissertation title: “Sex Differences in Gene Expression and Pain-Related Behaviors in a Preclinical Model of Migraine” Defended Ph.D. in Anatomy, 05/28/2010 (KUMC Student Travel Award, 2008-2010; KUMC Biomedical Research Training Program Award, 2010; Currently Resident Physician Internal Medicine, Oregon HSU) American Society for Pharmacology and Experimental Therapeutics [ASPET]


Summer Undergraduate Research Fellows (SURF) and other summer undergraduate trainees:

Summer 1996 Erica Greene ASPET SURF intern from Humbolt University Summer 1997 Nancy Deisher Summer medical student intern from KU-L 9/1996 - 6/1997 Nancy Deisher Part-time undergraduate research assistant Summer 1998 Christopher Graeber ASPET SURF intern from Bethel College Summer 1999 Rebecca Cohen ASPET SURF intern from Colorado College Summer 1999 Jason Moran ASPET SURF intern from Rockhurst College 9/1999 - 6/2000 Jason Moran Part-time undergraduate research assistant Summer 2000 Jenny Lang ASPET SURF intern from Baker University Summer 2000 Do Park Summer volunteer intern from Pembroke Hill HS Summer 2001 Janie Benoit ASPET SURF intern from Park University Summer 2002 Salvador Iloreta ASPET SURF intern from Tulane University Summer 2003 Stephanie Ihnow ASPET SURF intern from University of PA 2004 & 2005 Samantha Gordon ASPET SURF intern from Northwestern Univ. Summer 2006 Jacqueline Petzold ASPET SURF intern - Grand Valley State Univ. Summer 2007 Michelle Sparks ASPET SURF intern from Arizona State Univ. IGPBS / graduate student laboratory rotations:

Spring 1997 Eric Harstad departmental graduate student rotation Fall 1998 Julie Carlsten IGPBS student rotation Spring 2001 Christina Kaiser IGPBS student rotation Spring 2001 Amy Spears IGPBS student rotation Spring 2001 Jon Maher IGPBS student rotation Fall 2001 Rohan Gandhi IGPBS student rotation Spring 2002 Anna Nunn IGPBS student rotation Fall 2004 Scott Reisman IGPBS student rotation Departmental Master’s Thesis Committees:

1999 - 2000 Gulshan Begum Extra-Departmental Master’s Thesis Committees:

2004 - 2005 Joni Persson (Anatomy) Departmental Doctoral Dissertation Committees:

1997 - 1999 Jeff Moehlenkamp 1999 Mitchell Emerson 1997 - 2000 Lesley Rausch 1998 - 2000 Amy Mize 1999 - 2001 Eric Harstad 1999 - 2001 Grace Guo 2000 - 2003 Ning Li 2000 - 2003 Susan Buist 2002 - 2006 Toni Carpenter 2002 - 2005 Jon Maher 2002 - 2005 Xing Guo Cheng 2002 - 2006 Jagan Muppiddi (MD/PhD)


2007 - 2009 Hyuongwoo Bai 2008 – 2012 Amanda Hays (reader) 2008 – 2011 Megan Roth (reader) 2008 – 2012 Ann Thomas (reader) 2009 – 2013 Bradley Sullivan (reader) 2009 – 2013 Clarence David Williams (reader) 2009 - 2013 Kristen Russell 2010 - 2011 Stephanie Bishop 2010 – 2013 Hemantkumar Chavan (reader) 2010 – 2014 Felcy Selwyn Samraj (reader) 2010 – 2013 Michelle Healy Stoffel (reader) 2011 – 2014 Patrick Grogan (reader) 2011 – 2014 Chad Walesky (reader) 2011 – 2014 Sharon Manley (reader) 2011 – 2014 Le Zhan (reader) 2012 – 2015 Benjamin Woolbright (reader) 2012 – Yuchao Xie 2012 – Wen Zhao (reader) 2013 – Kuo Du (reader) 2014 - Jennifer McCracken 2014 - Steven McGreal (reader) Extra-Departmental Doctoral Dissertation Committees:

2000 - 2003 Julie Carlsten Christiansen (Anatomy) (currently a faculty member in the KUMC Department of Anatomy)

2002 - 2003 Michael Van Saun (Anatomy) 2003 - 2006 Rohan Gandhi (Neuroscience) 2004 - 2007 Alexandra Knudson (Anatomy MD/PhD) 2005 - 2006 Marcio Santos (Rehabilitation Science) 2005 - 2008 Megan Johnson (Anatomy) 2006 - 2008 Christopher Liverman (Anatomy MD/PhD) 2007 - 2011 Argenia Doss (Physiology) 2007 - 2010 Sarah Tague (Physiology) 2008 - 2012 Aritra Bhattacherjee (Physiology) 2010 - 2014 Anna Groover (Anatomy) 2011 - 2014 Natalie Katz (Anatomy MD/PhD) 2012 – 2013 Carrie McAllister (KU-L Pharmacology/Toxicology) 2012 – Angela Pierce (Neuroscience/Anatomy) 2013 - Isabella Fuentes (Anatomy) 2014 - Andrea Nuckolls (Neuroscience) 2015 - Michael Cooper (Neuroscience) 2015 - Olivia Eller (Neuroscience/Anatomy) Postgraduate trainees:

Summer 2001 Martin Simon, Ph.D Visiting Professor from Benedictine University Project: Vanilloid receptor expression and function in amphibians

2008 – 2012 Neena Sharma, Ph.D. Research Assistant Professor, Physical Therapy and Rehabilitation Sciences, Training Fellowship Mentee


Project: Exercise-Induced Neural Changes in Chronic Low Back Pain Patients

2012 - 2014 Lydia Vermeer, Ph.D. (Co-Major Advisor with Nancy Berman, Ph.D.) Project: Environmental Estrogens and Migraine Supported in part by NIH 5 T32 ES007079 Training Program in Environmental Toxicology (Currently Research Scientist at XenoTech, LLC) APPOINTMENTS AND COMMITTEES

University: Biomedical Research Training Program (BRTP) reviewer, 2015 KUMC Appointments, Promotion and Tenure Committee 2015 – present KUMC Institutional Animal Care and Use Committee (IACUC) 2010 – present KUMC School of Medicine Admissions Interviewer, 2010 - present KUMC Radiation Safety Committee 1996 – present (Vice Chair, 2008 – present) KUMC Institutional Research Safety Committee (IRSC) 1999 - 2013 KUMC School of Graduate Studies Travel Committee 1999 - present (Chair, 2004 - present) KUMC Graduate Council 2002 – 2008; 2012 - present KUMC IGPBS Steering Committee 2002 – 2008; 2012 - present University of Kansas Standing Committee on New Degrees and Degree Program Changes, 2003 – 2005 University of Kansas Standing Committee for Graduate Faculty Appointments and Authorizations, 2005 - 2006 University of Kansas Standing Committee for Program Review, 2006 - 2008 Neuroscience Program (Physiology) Faculty Recruitment Committee, 2004 - 2005 KIDDRC/MRRC Rodent Behavior Facility Advisory Committee, 2004 – present KUMC Pain Advisory Group, 2008 – present KUMC Pain Management Resource Committee (PMRC) 1996 - 2000 KUMC PMRC Physician Education Subcommittee 1996 - 1997 Departmental: Departmental Promotion and Tenure Committee 2015 – present Departmental Graduate Committee, 2000 – 2008; 2012 -present Chair/Director of Departmental Graduate Training Program, 2002 - 2008 Departmental Office Staff Ad Hoc Committee, 2004 Director, Departmental Seminar Series, 2001 - 2003 Director, Departmental ASPET Summer Undergraduate Research Fellowship Program, 2001 - 2008 Faculty Search Committee, 1996 – 1998; 2012 COBRE Recruitment search committee, 2012 - 2014 Editorial: Editorial Advisory Board Member (5/00 – 6/03) Current Drug Targets - CNS and Neurological Disorders

Reviewer for Doody Publishing’s Online Reviews, 2002-2015 Records Currency reviewer for xPharm (Elsevier) electronic database, 2014 - 2015


Ad Hoc Reviewer for: Amino Acids Anesthesia and Analgesia Basic & Clinical Pharmacology & Toxicology Behavioural Brain Research Biochemical Pharmacology BioMed Research International Biomedical Signal Processing and Control Brain, Behavior, and Immunity Brain Research Brain Research Bulletin British Journal of Pharmacology DNA and Cell Biology European Journal of Lipid Science and Technology European Journal of Neuroscience European Journal of Pain European Journal of Pharmacology Experimental and Clinical Psychopharmacology Experimental Biology and Medicine Experimental Neurology Headache Hippocampus Journal of Inflammation Journal of Investigative Dermatology Journal of Neuroscience Journal of Neuroscience Research Journal of Neurochemistry Journal of Pain Journal of Pharmacology and Experimental Therapeutics Life Sciences Molecular and Cellular Neuroscience Molecular Pain Molecular Pharmacology Neuropeptides Neuropsychopharmacology Neurorehabilitation and Neural Repair Neuroscience Neuroscience Letters NeuroSignals Pain Peptides Pharmacology & Therapeutics PLoS Genetics PLoS ONE Progress in Neuro-Psychopharmacology and Biological Psychiatry Restorative Neurology and Neuroscience Synapse


Grant and External Academic Review: Reviewer, NIH NIDA ZDA1 HXO-H (01-05), PA-11-197 NIH Pathway to Independence Award (Parent K99/R00) Grant Review Panel, March 2015 Reviewer, NIH NIDA ZDA1 HXO-H (01, 04), (T32) Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants and NIH Pathway to Independence Award (Parent K99/R00) -Grant Review Panel, October 2014 (Served as panel chair during chairman review conflicts) Reviewer, NIH NIDA ZDA1 EXL-T (02), PA-14-042 NIH Pathway to Independence Award (Parent K99/R00) Panel, June 2014 (Served as panel chair during chairman review conflicts) Reviewer, Scientific Peer Advisory and Review Services division of the American Institute of Biological Sciences (AIBS) for the US Army Medical Research and Materiel Command (USAMRMC), May 2014 Reviewer, Kentucky Science & Engineering Foundation (KSEF), R&D Excellence Awards Program, April 2014 Reviewer, NIH NIDA ZDA1 EXL-T (01), PA-11-197 NIH Pathway to Independence Award (Parent K99/R00) Panel, March 2014 (Served as panel chair during chairman review conflicts) Reviewer, NIH NIDDK ZDK1 GRB-G (M3 & M4) Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Special Emphasis Panel, February 2014 Reviewer, KUMC Research Institute Frontiers Clinical Pilot and Collaborative Studies Funding Program, 2012 - 2014 Reviewer, NIH NIDA ZDA1 EXL-T (02), (T32) Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants--Grant Review Panel, November 2013 (Served as panel chair during chairman review conflicts) Reviewer, NIH NIDA ZDA1 EXL-T (01), SEDAPA R25: PAR 13-084, PAR 12-199 and PAR 10-227 Grant Review Panel, November 2013 Reviewer, American Institute of Biological Sciences (AIBS) Scientific Peer Advisory and Review Services Division, on behalf of the US Army Medical Research and Materiel Command (USAMRMC) Combat Casualty Care Research Program (CCCRP), August 2013 Reviewer, NIH NIDA ZDA1 EXL-T (02), PA-11-197 NIH Pathway to Independence Award (Parent K99/R00) Panel, June 2013 (Served as panel chair during chairman review conflicts) Reviewer, NIH ZRG1 PSE-P (02) M, Member Conflict: Chronic Disease, Aging, and Genetics Panel, March 2013 Reviewer, NIH NIDA ZDA1 EXL-T (07) 1, PA-11-197 NIH Pathway To Independence Award (Parent K99R00) Panel, March 2013 Reviewer, Partner University Fund (PUF) Embassy of France Grant Program 2012 -2013 Reviewer, KUMC Research Institute Internal Clinical Pilot Research Grant and Lied Basic Science Grant Programs, 2012 - 2013 Reviewer, Pennsylvania Department of Health Final Performance Review, Oak Ridge Associated Universities Grant Program, 2012 -2013 Reviewer, The State University of New York University at Buffalo, Department of Pathology and Anatomical Sciences Promotion and Tenure Review, 2011 Reviewer, Kansas Center for Autism Research and Training (K-CART) Pilot Grant Program, 2010 - 2011 Reviewer, NIH NIDA-K Training and Career Development Review Committee


Ad Hoc Reviewer; 2003-2011 Standing Member; 2011- 2012 Reviewer, NIH NIDA-K Conflicts of Interest Special Emphasis Panel; 2003-2012 Reviewer, NIH NIDA ARRA New Faculty Recruitment P30 SEP, July 2009 Reviewer, Kentucky Science & Engineering Foundation (KSEF), R&D Excellence Awards Program, May 2009 Reviewer, NIH NCCAM Centers for Excellence in Research Special Emphasis Panel (ZAT1 SM 11), June 2008 Reviewer, NIH NIDCR Special Emphasis Panel (RFA DE-07-006), March 2007 Reviewer, NIMH Minority Research Infrastructure Support Program (M-RISP) Special Emphasis Panel (ZMH1 ERB-N), 10/2006. Reviewer, The Wellcome Trust, London, UK; 2002, 2006 Reviewer, Israel Science Foundation, 2006 Reviewer, Biotechnology and Biological Sciences Research Council (UK), 2005 Reviewer, NHS Grampian Trust Research Projects (University of Aberdeen, UK); 2004 Reviewer, NIH Chronic Fatigue Syndrome/Fibromyalgia Syndrome / Temporomandibular Dysfunction Special Emphasis Panel, 12/2004 Reviewer, Division on Earth and Life Studies The National Academy of Sciences on behalf of the State of Ohio BRTT Partnership Award Program, May 2003 Reviewer, John Sealy Foundation, Univ. of Texas Medical Branch, Galveston, TX; 2001-2002 PROFESSIONAL CONSULTATION

Consultant for Hudson & Mullies, L.L.C. and Wallace & Saunders in Russell v. White (Medical Liability case), June 2008

Consultant for Tory’s L.L.P., representing Pfizer Canada Inc., Warner-Lambert Company and Warner-Lambert Company LLC (Pfizer), and The Board of Regents for the University of Oklahoma in Pfizer Canada Inc. et al. v. Novopharm Limited et al. (Notice of Allegation dated October 1, 2009) in litigation involving Canadian Patent Nos. 2,134,674; 2,255,652; 2,325,045; 2,327,285; and 2,297,163 (Court File No. T-1868-09) related to the medicine LYRICA® (pregabalin). Researched and provided affidavit to Canadian Court. December 2009 – November 2010.

Consultant for Tory’s L.L.P., representing Pfizer Canada Inc., Warner-Lambert Company and Warner-Lambert Company LLC (Pfizer), and The Board of Regents for the University of Oklahoma in Pfizer Canada Inc. et al. v. Ratiopharrn Inc.. et al. (Notice of Allegation dated July 7,2009) in litigation involving Canadian Patent Nos. 2,134,674; 2,255,652; 2,325,045; 2,327,285; and 2,297,163 (Court File No. T-1422-09) related to the medicine LYRICA® (pregabalin). Researched and provided affidavits and cross examination before the Canadian Court. December 2009 – November 2010.

Consultant for Shaffer, Lombardo, Shurin, Attorneys at Law in Hey vs. Alt, D.O., et al. (Medical Liability case), January 2011.

Consultant for Shaffer, Lombardo, Shurin, Attorneys at Law in Johnson v. Marjara, MD, et al. (Medical Liability case), January 2011.


Consultant for Shaffer, Lombardo, Shurin, Attorneys at Law in Moore v. Carper, DO et al. (Medical Liability case), January 2011.

Consultant for Tory’s L.L.P., representing Pfizer Canada Inc., Warner-Lambert Company and Warner-Lambert Company LLC (Pfizer), and The Board of Regents for the University of Oklahoma in Pfizer Canada Inc. et al. v. Pharmascience Inc. et al. (Notice of Allegation dated February 11, 2011) in litigation involving Canadian Patent Nos. 2,134,674; 2,255,652; 2,325,045; 2,327,285; and 2,297,163 (Court File No. T-556-11) related to the medicine LYRICA® (pregabalin). Researched and provided affidavits and cross examination before the Canadian Court. April 2011 – June 2012.

Consultant for Tory’s L.L.P., representing Pfizer Canada Inc., Warner-Lambert Company and Warner-Lambert Company LLC (Pfizer), and The Board of Regents for the University of Oklahoma in Pfizer Canada Inc. et al. v. Laboratoire Riva Inc. et aI. (Notices of Allegation dated December 6, 2011) in litigation involving Canadian Patent No. 2, 255,652 (Court File No. T-217-12) related to the medicine LYRICA® (pregabalin). Retained as consultant, February 2012

Consultant for Tory’s L.L.P., representing Pfizer Canada Inc., Warner-Lambert Company and Warner-Lambert Company LLC (Pfizer), and The Board of Regents for the University of Oklahoma in Pfizer Canada Inc. et al. v. Ranbaxy Pharmaceuticals Canada Inc. et al. (Notices of Allegation dated July 28, 2011) in litigation involving Canadian Patent No. 2, 255,652 (Court File No. T-1498-11) related to the medicine LYRICA® (pregabalin). Retained as consultant, March 2012

Consultant for Seigfreid Bingham, PC in Ward v. Bennett Packaging (Wrongful Termination case related to oxycodone and benzodiazepine use). Provided research and document review as well as trial testimony. August 2012– November 2012.

Signatory on Amicus Brief in the Supreme Court of the United States, “Brief Of Sixteen Professors of Pharmacology as Amicus Curiae in Support of Neither Party,” (No. 14-7955; Crowell & Morning, LLP, New York) on behalf of pharmacologists in the Glossip v. Gross lethal injection case, addressing pharmacological differences between barbiturates and benzodiazepines. March 2015 BIBLIOGRAPHY Refereed Journal Publications: 1. McCarson, K.E., and Goldstein, B.D. Naloxone blocks the formalin-induced increase of

substance P in the dorsal horn. Pain, 38 (1989) 339-345. PMID: 2478946 2. McCarson, K.E., and Goldstein, B.D. Timecourse of the alteration in substance P levels in

the dorsal horn following formalin: blockade by naloxone. Pain, 41 (1990) 95-100. PMID: 1693764

3. McCarson, K.E., and Goldstein, B.D. Release of substance P into the superficial dorsal horn following nociceptive activation of the hindpaw of the rat. Brain Research, 568 (1991) 109-115. PMID: 1726066

4. Krause, J.E., Bu, J.-Y., Takeda, Y., Blount, P., Raddatz, R., Sachais, B.S., Chou, K.B., Takeda, J., McCarson, K., and DiMaggio, D. Structure, expression and second-


messenger-mediated regulation of the human and rat substance P receptors and their genes. Regulatory Peptides, 46 (1993) 59-66. PMID: 7692568

5. McCarson, K.E., and Krause, J.E. NK-1 and NK-3 type tachykinin receptor mRNA expression in the rat spinal cord dorsal horn is increased during adjuvant or formalin-induced nociception. Journal of Neuroscience, 14 (1994) 712-720. PMID: 8301359

6. Ludlam, W.H., Zang, Z., McCarson, K.E., Krause, J.E., Spray, D.C., and Kessler, J.A. mRNAs encoding muscarinic and substance P receptors in cultured sympathetic neurons are differentially regulated by LIF or CNTF. Developmental Biology, 164 (1994) 528-539. PMID: 7519157

7. Röder, C., Bellman, R., McCarson, K.E., Krause, J.E., and Sperk, G. Kainic acid-induced seizures cause a marked increase in the expression of neurokinin-3 receptor mRNA in the rat cerebellum. Neuroscience Letters, 181 (1994) 158-160. PMID: 7898759

8. McCarson, K.E., and Krause, J.E. The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration. Neuroscience, 64 (1995) 729-739. PMID: 7536308

9. Thompson, S.W.N., Dray, A., McCarson, K.E., Krause, J.E., and Urban, L. Nerve growth factor induces mechanical allodynia associated with neurokinin-1 receptor activation and novel A fibre-evoked spinal reflex activity in the rat. Pain, 62 (1995) 219-231. PMID: 8545148

10. Krause, J.E., DiMaggio, D.D., and McCarson, K.E. Alterations in neurokinin-1 receptor gene expression in models of pain and inflammation. Canadian Journal of Physiology and Pharmacology, 73 (1995) 854-859. PMID: 8846421

11. McCarson, K.E., and Krause, J.E. The neurokinin-1 receptor antagonist LY306,740 blocks nociception-induced increases in dorsal horn neurokinin-1 receptor gene expression. Molecular Pharmacology, 50 (1996) 1189-1199. PMID: 8913350

12. McCarson, K.E., and Enna, S.J. Relationship between GABAB receptor activation and neurokinin receptor expression in spinal cord. Pharmacology Reviews and Communications, 8 (1996) 191-194.

13. Enna, S.J., Harstad, E.B., and McCarson, K.E. Regulation of neurokinin-1 receptor expression by GABAB receptor agonists. Life Science, 62 (1998) 1525-1530. PMID: 9585130

14. McCarson, K.E., Krause, J.E., and McLean, S. Chronic nonpeptide neurokinin-1 receptor antagonist treatment alters striatal tachykinin peptide and receptor gene expression. Neuroscience Letters, 251(1998) 113-116. PMID: 9718987

15. Abrahams, L.G., Reutter, M.A, McCarson, K.E., and Seybold, V.S. Cyclic AMP regulates the expression of neurokinin1 receptors by rat spinal neurons in culture. Journal of Neurochemistry, 73 (1999) 50-58. PMID: 10386954

16. McCarson, K.E. Central and peripheral expression of neurokinin-1 and neurokinin-3 receptor and substance P-encoding mRNAs: peripheral regulation during formalin-induced inflammation and lack of neurokinin receptor expression in primary afferent sensory neurons. Neuroscience, 93 (1999) 361-370. PMID: 10430499


17. McCarson, K.E. and Enna, S.J. Nociceptive regulation of GABAB receptor gene expression in sensory systems of the rat. Neuropharmacology, 38(1999) 1767-1773. PMID: 10587092

18. Linden, D.R., Reutter, M.A., McCarson, K.E., and Seybold, V.S. Time-dependent changes in neurokinin3 receptors and tachykinins during adjuvant-induced peripheral inflammation in the rat. Neuroscience 98 (2000) 801-811. PMID: 10891623

19. Mogil, J.S., and McCarson, K.E. Identifying pain genes: bottom-up and top-down approaches. Journal of Pain 1 [Suppl. 1] (2000) 66-80. PMID: 14622845

20. Moran, J.M. Enna, S.J., and McCarson, K.E. Developmental regulation of GABAB receptor function in rat spinal cord. Life Science 68 (2001) 2287-2295. PMID: 11358338

21. Chronwall, B.M., Davis, T.D., Severidt, M.W., Wolfe, S.E., McCarson, K.E., Beatty, D.M., Low, M.J., Morris, S.J., and Enna, S.J. Constitutive expression of GABAB receptors in mIL-tsA58 cells requires both GABAB1 and GABAB2 genes. Journal of Neurochemistry 77 (2001) 1237-1247. PMID: 11389174

22. Levant, B. and McCarson, K.E. D3 dopamine receptors in rat spinal cord: implications for sensory and motor function. Neuroscience Letters 303 (2001) 9-12. PMID: 11297811

23. Collins, J.J., Usip, S., McCarson, K.E. and Papka, R.E. Sensory nerves and neuropeptides in uterine cervical ripening. Peptides 23 (2002) 167-183. PMID: 11814632

24. Velázquez, R.A., McCarson, K.E., Cai, Y., Kovacs, K., Shi, Q., Evensjö, M. and Larson, A.A. Up-regulation of neurokinin-1 receptor expression in the rat spinal cord by an N-terminal metabolite of substance P. European Journal of Neuroscience 16 (2002) 229-241. PMID: 12169105

25. Allen, A.L., Cortright, D.N., and McCarson, K.E. Formalin- or adjuvant-induced peripheral inflammation alters neurokinin-1 receptor gene expression in the mouse. Brain Research 961 (2003):147-52. PMID: 12535787

26. Seybold, V.S., McCarson, K.E., Mermelstein, P.G., Groth, R.D., and Abrahams, L.G. Calcitonin gene-related peptide regulates expression of neurokinin1 receptors by rat spinal neurons. Journal of Neuroscience 23 (2003):1816-24. PMID: 12629185

27. Sands, S.A., McCarson, K.E., and Enna, S.J. Differential regulation of GABAB receptor subunit expression and function. Journal of Pharmacology and Experimental Therapeutics 305 (2003) 191-6. PMID: 12649368

28. Christianson, J.A., Ryals, J.M., McCarson, K.E., and Wright, D.E. Beneficial actions of neurotrophin treatment on diabetes-induced hypoalgesia in mice. Journal of Pain 4 (2003) 493–504. PMID: 14636817

29. Sands, S.A., McCarson, K.E., and Enna, S.J. Relationship between the antinociceptive response to desipramine and changes in GABAB receptor function and subunit expression in the dorsal horn of the rat spinal cord. Biochemical Pharmacology 67 (2004) 743-9. PMID: 14757174

30. Wright, D.E., Ryals, J.M., McCarson, K.E., and Christianson, J.A. Diabetes-induced expression of activating transcription factor 3 in mouse primary sensory neurons. Journal of the Peripheral Nervous System 9 (2004) 242-54. PMID: 15574137


31. Taylor, B.K., and McCarson, K.E. Neurokinin-1 receptor gene expression in the mouse dorsal horn increases with neuropathic pain. Journal of Pain 5 (2004) 71-6. PMID: 15042514

32. Allen, A.L. and McCarson, K.E. Estrogen increases nociception-evoked brain-derived neurotrophic factor gene expression in the female rat. Neuroendocrinology 81 (2005)193-199. PMID: 16020928

33. Duric, V. and McCarson, K.E. Hippocampal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression is decreased in rat models of pain and stress. Neuroscience 133 (2005) 999-1006. PMID: 15964488

34. Winter, M.K. and McCarson, K.E. G-protein activation by neurokinin-1 receptors is dynamically regulated during persistent nociception. Journal of Pharmacology and Experimental Therapeutics 315 (2005) 214-221. PMID: 15985614

35. McCarson, K.E., Ralya, A., Reisman, S.A., and Enna, S.J. Amitriptyline prevents thermal hyperalgesia and modifications in rat spinal cord GABA(B) receptor expression and function in an animal model of neuropathic pain. Biochemical Pharmacology 71 (2005) 196-202. PMID: 16293232

36. McCarson, K.E., Duric, V., Reisman, S.A., Winter, M., and Enna, S.J. GABA(B) receptor function and subunit expression in the rat spinal cord as indicators of stress and the antinociceptive response to antidepressants. Brain Research 1068 (2006) 109-117. PMID: 16368079

37. Enna, S.J., and McCarson, K.E. The role of GABA in the mediation and perception of pain. Advances in Pharmacology 54 (2006) 1-27. PMID: 17175808

38. Duric, V. and McCarson, K.E. Persistent pain produces stress-like alterations in hippocampal neurogenesis and gene expression. Journal of Pain 7 (2006) 544-555. PMID: 16885011

39. Duric, V. and McCarson, K.E. Effects of analgesic or antidepressant drugs on pain- or stress-evoked hippocampal and spinal neurokinin-1 (NK-1) receptor and brain-derived neurotrophic factor (BDNF) gene expression in the rat. Journal of Pharmacology and Experimental Therapeutics 319 (2006) 1235-43. PMID: 16956981

40. Duric, V. and McCarson, K.E. Hippocampal mechanisms linking chronic pain and depression. Journal of Neuropathic Pain & Symptom Palliation. 2 (2006) 15-32.

41. Pierce, J., Levant, B., Jegathesan, J., Winter, M., McCarson, K.E., & Clancy, R. Detection of dopamine receptor subtypes in the rat diaphragm. Heart and Lung 36 (2007) 58-63. PMID: 17234478

42. Rook, J.M. and McCarson, K.E. Delay of cutaneous wound closure by morphine via local blockade of peripheral tachykinin release. Biochemical Pharmacology 74 (2007) 752-757. PMID: 17632084; PMCID: PMC1997302.

43. Duric, V. and McCarson, K.E. Neurokinin-1 (NK-1) receptor and brain-derived neurotrophic factor (BDNF) gene expression is differentially modulated in the rat spinal dorsal horn and hippocampus during inflammatory pain. Molecular Pain 3 (2007) 32. PMID: 17974009; PMCID: PMC2174921

44. Rook, J.M., Hasan, W., and McCarson, K.E. Temporal effects of topical morphine application on cutaneous wound healing. Anesthesiology 109(2008)130-136. PMID: 18580183; PMCID: PMC2598738


45. Levant, B., Ozias, M.K., Davis, P.F., Winter, M.K., Russell, K.L., Carlson, S.E., Reed, G.S., and McCarson, K.E. Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: interactions with reproductive status in female rats. Psychoneuroendocrinology 33 (2008) 1279-1292. PMID: 18707812; PMCID: PMC2582014

46. Liverman C., Brown, J., Sandhir, R., Klein, R., McCarson, K.E., and Berman, N.J. Oestrogen increases nociception through ERK activation in the trigeminal ganglion: evidence for a peripheral mechanism of allodynia. Cephalalgia 29 (2009): 520-31. PMID: 19210515; PMCID: PMC2671577

47. Liverman C., Brown, J., Sandhir, R., Klein, R., McCarson, K.E., and Berman, N.J. Role of the estrogen receptors GPR30 and ERα in peripheral sensitization: relevance to trigeminal pain disorders in women. Cephalalgia 29 (2009) 729-741. PMID: 19220308; PMCID: PMC4054707.

48. Rook, J.M., Hasan, W., and McCarson, K.E. Morphine-induced early delays in wound closure: involvement of sensory neuropeptides and modification of neurokinin receptor expression. Biochemical Pharmacology 77 (2009)1747-1755. PMID: 19428329; PMCID: PMC4159122.

49. Davis, P.F., Ozias, M.K., Carlson, S.E., Reed, G.A., Winter, M.K., McCarson, K.E., and Levant, B. Dopamine receptor alterations in female rats with diet-induced decreased brain docosahexaenoic acid (DHA): Interactions with reproductive status. Nutritional Neuroscience 13 (2010) 161-169. PMID: 20670471; PMCID: PMC2955509

50. Ghose, S, Winter, M. K., McCarson, K.E., Tamminga, C.A., and Enna, S.J. The GABAB receptor as a target for antidepressant drug action. British Journal of Pharmacology 162 (2011) 1-17. PMID: 20735410; PMCID: PMC3012402

51. Chakrabarty, A., McCarson, K.E., and Smith, P.G. Hypersensitivity and hyperinnervation of the rat hind paw following carrageenan-induced inflammation. Neuroscience Letters 495 (2011) 67-71. PMID: 21439352; PMCID: PMC3119508

52. Stucky, N.L, Gregory, E., Winter, M.K., He, Y.Y., Hamilton, E., McCarson, K.E., and Berman, N.E. Sex differences in behavior and expression of CGRP-related genes in a rodent model of chronic migraine. Headache 51 (2011) 674-692. PMID:21521205; PMC PMC4079043

53. Sharma, N.K., McCarson, K.E., Van Dillen, L., Lentz, A., Khan, T., and Cirstea, C.M. Primary somatosensory cortex in chronic low back pain – a 1H-MRS study. Journal of Pain Research 4 (2011) 143-150. PMID: 21647218; PMCID: PMC3100229

54. Gupta, S., McCarson, K.E., Welch, K.M.A., and Berman, N.E.J. Mechanisms of pain modulation by sex hormones in migraine. Headache 51 (2011) 905-922. PMID: 21631476; PMC Journal in Process.

55. Tague, S.E., Clarke, G.L., Winter, M.K., McCarson, K.E., Wright, D.E., Smith, P.G. Vitamin D deficiency promotes skeletal muscle hypersensitivity and sensory hyperinnervation. Journal of Neuroscience 31 (2011) 13728 – 13788. PMID: 21957236; PMCID: PMC3319727.

56. Sharma, N.K., Brooks, W.M., Popescu, A.E., Van Dillen, L., George, S.Z., McCarson, K.E., Gajewski, B.J., Gorman, P., and Cirstea, C.M. Neurochemical analysis of primary motor cortex in chronic low back pain. Brain Sciences 2 (2012) 319-331. PMID: 23766894; PMCID: PMC3678773


57. Corder, G., Doolen, S., Donahue, R.R., Winter, M.K., Jutras, B.L., He, Y., Hu, X., Wieskopf, J.S., Mogil, J.S., Storm, D.R., Wang, Z.J., McCarson, K.E., and Taylor, B.K. Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence. Science. 341 [6152] (2013) 1394-1399. PMID: 24052307; PMC Journal in Process. (Cover Article)

58. Taylor, B.K., Fu, W., Kuphal, K.E., Stiller, C.O., Winter, M.K., Chen, W., Corder, G.F., Urban, J.H., McCarson, K.E., and Marvizon, J.C. Inflammation enhances Y1 receptor signaling, neuropeptide Y-mediated inhibition of hyperalgesia, and substance P release from primary afferent neurons. Neuroscience 256 (2013) 178-194. PMID: 24184981; PMC Journal in Process.

59. Enna, S.J. and McCarson, K.E. Characterization of GABA Receptors. Current Protocols in Pharmacology 63 (2013) 1.7.1-1.7.20. PMID: 24510754; PMCID: PMC3927317.

60. Vermeer, L.M., Gregory, E., Winter, M.K., McCarson, K.E., and Berman, N.E. Exposure to Bisphenol A exacerbates migraine-like behaviors in a multibehavior model of rat migraine. Toxicological Sciences 137[2] (2014) 416-427. PMID: 24189132; PMCID: PMC3908719.

61. Krizsan-Agbas, D., Winter, M.K., Eggimann, L.S., Meriwether, J., Berman, N.E., Smith, P.G, and McCarson, K.E. Gait analysis at multiple speeds reveals differential functional and structural outcomes in response to graded spinal cord injury. Journal of Neurotrauma 31[9] (2014) 846-56. PMID: 24405378; PMCID: PMC3996941.

62. McCarson, K.E., and Enna, S.J. GABA Pharmacology: The Search for Analgesics. Neurochemical Research 39[10] (2014) 1948-1963. PMID: 24532294; PMC Journal in Process.

63. Ralya, A.,and McCarson, K.E. Acute estrogen surge enhances inflammatory nociception without altering spinal Fos expression. Neuroscience Letters 575 (2014) 91-95. PMID: 24861514; PMCID: PMC4104118

64. Vermeer, L.M., Gregory, E., Winter, M.K., McCarson, K.E., and Berman, N.E. Behavioral effects and mechanisms of migraine pathogenesis following estradiol exposure in a multibehavioral model of migraine in rat. Experimental Neurology 263 (2015) 8-16. PMID: 25263582; PMC Journal in Process.

65. Fehrenbacher, J.C., Vasko, M.R., Duarte, D.B., and McCarson, K.E. Models of Inflammation: Carrageenan- or Complete Freund’s Adjuvant (CFA)–Induced Edema and Hypersensitivity in the Rat. Current Protocols in Pharmacology (in press)

66. Ralya, A., and McCarson, K.E. Exogenous testosterone promotes thermal hypoalgesia in male rats. Physiology and Behavior (submitted).

67. Ralya, A., and McCarson, K.E. Complex behavioral manifestations of formalin-evoked nociception are revealed by force-plate actimetry. (in preparation for submission to Journal of Neuroscience Methods).

Invited, Peer-Reviewed Internet Database Chapters: 1. McCarson, K.E. Tachykinin Receptors. xPharm: The Comprehensive Pharmacology

Reference, Elsevier. (2007) 1-3. http://www.sciencedirect.com/science/referenceworks/9780080552323

http://www.sciencedirect.com/science/referenceworks/9780080552323


2. McCarson, K.E. L703606. xPharm: The Comprehensive Pharmacology Reference, Elsevier. (2007) 1-4. http://www.sciencedirect.com/science/referenceworks/9780080552323

3. McCarson, K.E. [Sar9,Met(O2)11]Substance P. xPharm: The Comprehensive Pharmacology Reference, Elsevier. (2007) 1-5. http://www.sciencedirect.com/science/referenceworks/9780080552323

4. Bockman C.S., Eckerson J., and McCarson, K.E. Myalgia. Reference Module in Biomedical Sciences (Michael Caplan, ed.), Elsevier. (2015) doi: 10.1016/B978-0-12-801238-3.05161-8; http://www.elsevier.com/online-tools/sciencedirect/books#reference-modules

Book Chapters: 1. Enna, S.J. and McCarson, K.E.: Characterization of GABA Receptors. In: Current

Protocols in Pharmacology, S.J. Enna and M. Williams (eds.), Wiley, New York, (1998) 1.7.1-1.7.18.

Invited Commentary Articles: 1. McCarson, K. E. How to Become a ‘Rat Whisperer’ — 7 Tips on Handling Lab Rodents.

Laboratory Animal Welfare Compliance, 1(2010) 13-15. (http://principalinvestigators.org/pdf/LAWC-July-2010-Sneak-Peak.pdf)

Invited Book Reviews: 1. McCarson, K. E. Review of Pain: Current Understanding, Emerging Therapies and Novel

Approaches to Drug Discovery. Marcel Dekker, Inc., 2003. Doody’s Review Service (on-line). Available: http://www.doody.com. (Accessed 09/18/2003).

2. McCarson, K. E. Review of Encyclopedic Reference of Molecular Pharmacology. Springer Verlag, 2003. Doody’s Review Service (on-line). Available: http://www.doody.com. (Accessed 01/27/2004).

3. McCarson, K. E. Review of The Delta Receptor. Marcel Dekker, Inc., 2003. Doody’s Review Service (on-line). Available: http://www.doody.com. (Accessed 01/27/2003).

4. McCarson, K. E. Review of Hyperalgesia: Molecular Mechanisms and Clinical Implications. International Association for the Study of Pain, 2004, Doody’s Review Service (on-line). Available: http://www.doody.com. (Accessed 11/25/2004).

5. McCarson, K. E. Review of Sodium Channels, Pain, and Analgesia. Birhauser Verlag 2005, Doody’s Review Service (on-line). Available: http://www.doody.com. (Accessed 01/05/2006).

6. McCarson, K. E. Review of Turning Up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation. Birhauser Verlag 2005, Doody’s Review Service (on-line). Available: http://www.doody.com. (Accessed 01/05/2006).



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7. McCarson, K. E. Review of Marijuana and Cannabinoid Research: Methods and Protocols. Humana 2006, Doody’s Review Service (on-line). Available: http://www.doody.com. (Accessed 04/05/2006).

8. McCarson, K. E. Review of Short Protocols in Pharmacology and Drug Discovery. John Wiley & Sons, Inc., 2007, Doody’s Review Service (on-line). Available: http://www.doody.com. (Accessed 10/08/2007).

9. McCarson, K. E. Review of The Glutamate Receptors. Humana Press, Inc., 2008, Doody’s Review Service (on-line). Available: http://www.doody.com. (Accessed 07/07/2008).

10. McCarson, K. E. Review of The Opiate Receptors. Humana Press, Inc., 2011, Doody’s Review Service (on-line). Available: http://www.doody.com.

11. McCarson, K. E. Review of Receptor Signal Transduction Protocols, 3rd Edition.. Humana Press, Inc., 2012, Doody’s Review Service (on-line). Available: http://www.doody.com.

12. McCarson, K. E. Review of Therapeutic Targets: Modulation, Inhibition, and Activation. Wiley-Blackwell, Inc., 2013, Doody’s Review Service (on-line). Available: http://www.doody.com. (Accessed 03/01/2013).

13. McCarson, K. E. Review of Molecular Pharmacology: From DNA to Drug Discovery. Wiley-Blackwell, Inc., 2013, Doody’s Review Service (on-line). Available: http://www.doody.com. (Accessed 07/26/2013).

14. McCarson, K. E. Review of Capsaicin as a Therapeutic Molecule. Springer, 2014, Doody’s Review Service (on-line). Available: http://www.doody.com. (Accessed 07/08/2014).

15. McCarson, K. E. Review of A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4th Edition. Elsevier, 2014, Doody’s Review Service (on-line). Available: http://www.doody.com. (Accessed 09/30/2014).

16. McCarson, K. E. Review of The Endocannabinoidome: The World of Endocannabinoids and Related Mediators. Elsevier, 2015, Doody’s Review Service (on-line). Available: http://www.doody.com. (Accessed 05/04/2015).

17. McCarson, K. E. Review of Handbook of Toxicology of Chemical Warfare Agents, 2nd Edition, 2015, Doody’s Review Service (on-line). Available: http://www.doody.com. (Accessed 07/23/2015).

Abstracts: 1. McCarson, K.E., Goldstein, B.D., and Kirby, M.L. Morphine increases substance P in the

dorsal horn during a nociceptive stimulus. Neuroscience Abstracts, 13 (1987) 1589. 2. McCarson, K.E., and Goldstein, B.D. Naloxone blocks the increase of substance P in the

dorsal horn due to a nociceptive stimulus. Neuroscience Abstracts, 14 (1988) 563. 3. McCarson, K.E., and Goldstein, B.D. Formalin increases dorsal horn substance P

content. Neuroscience Abstracts, 15 (1989) 468.













4. Goldstein, B.D., Holland, L.N., and McCarson, K.E. Formalin-induced changes in substance P levels and release correlate with pain-related behaviors. Neurobiology of Nociception, 1 (1990) 39.

5. McCarson, K.E., and Goldstein, B.D. Alteration of the substance P content of primary afferent neurons by nociceptive stimulation. Neuroscience Abstracts, 17 (1991) 439.

6. McCarson, K.E., and Krause, J.E. Regulation of tachykinin receptor mRNA expression in the dorsal horn during nociception. Neuroscience Abstracts, 18 (1992) 1022.

7. Ludlam, W.H., McCarson, K.E., Krause, J.E., and Kessler, J.A. Cytokine induced stimulation of mRNA encoding the receptor for substance P in sympathetic neurons. Neuroscience Abstracts, 19 (1993) 1729.

8. McCarson, K.E., and Krause, J.E. Morphine blocks the formalin-induced increase in dorsal horn NK-1 receptor mRNA expression. Neuroscience Abstracts, 19 (1993) 1411.

9. Krause, J.E., McCarson, K.E., and DiMaggio, D.D. Mechanisms of tachykinin receptor sensitivity. Japanese Journal of Pharmacology, 67 supplement I (1995) 80P.

10. McCarson, K.E., and Krause, J.E. Molecular and cellular mechanisms contributing to the regulation of neurokinin-1 receptor gene expression following formalin-induced nociception. TACHYKININS ‘95 (1995) 80.

11. McCarson, K.E., and Krause, J.E. Transcriptional activation contributes to the regulation of neurokinin-1 receptor gene expression in the dorsal horn of the rat following formalin-induced nociception. Neuroscience Abstracts, 21 (1995) 96.

12. McCarson, K.E., and Enna, S.J. Interaction between GABAB receptor activation and neurokinin-1 receptor gene expression in rat spinal cord during nociception. Neuroscience Abstracts, 22 (1996) 1359.

13. McCarson, K.E.. Formalin-induced nociception produces hyperalgesia and increases neurokinin-1 receptor gene expression in inflamed rat hindpaw tissues. Tachykinins in Health and Disease (1997) 59.

14. Harstad, E. B., Enna, S.J., and McCarson, K.E. Differential tolerance to the analgesic and sedative effects of GABAB receptor agonists in rats. Neuroscience Abstracts, 23 (1997) 1813.

15. McCarson, K.E. Formalin-induced nociception produces hyperalgesia and increases neurokinin-1 receptor gene expression in inflamed rat hindpaw tissues. Neuroscience Abstracts, 23 (1997) 1536.

16. Velasquez, R.A., McCarson, K.E., and Larson, A.A. Intrathecal capsaicin or SP1-7 treatment increases neurokinin-1 receptor gene expression in the rat spinal cord. Neuroscience Abstracts, 23 (1997) 442.

17. McCarson, K.E. and Enna, S.J. GABAB receptor regulation of neurokinin-1 gene expression in rat spinal cord. Journal of Neurochemistry 69 (1997) S51.

18. Enna, S.J., Harstad, E.B., and McCarson, K.E. Regulation of neurokinin-1 receptor expression by GABAB receptor agonists. 2nd International Symposium Membrane Receptor-Signaling System, Sapporo, Japan (1997).

19. McCarson, K.E., and Enna, S.J. GABAB receptor regulation of neurokinin-1 receptor gene expression in rat spinal cord. ISN/ASN ‘97 Meeting (1997).


20. Deisher, N.E. and McCarson, K.E. The NK-1 receptor antagonist RP 67580 blocks formalin-evoked NK-1 receptor gene expression in central and peripheral rat tissues. Neuroscience Abstracts, 24 (1998) 1865.

21. Kamp, E.H., McCarson, K.E., and Gebhart, G.F. The role of substance P receptors in the production of colonic inflammation in trinitrobenzene sulfonic acid (TNBS) treated rats. Neuroscience Abstracts, 24 (1998) 1864.

22. Velázquez, R.A., McCarson, K.E., Shi, Q., Evensjö, A. M. and Larson, A.A. Capsaicin-induced changes in Substance P (SP) synthesis and the expression of neurokinin-1 (NK-1) receptors in the spinal cord: role of SP N-terminal metabolites. Neuroscience Abstracts, 24 (1998) 389.

23. Seybold, V.S., Reutter, M., McCarson, K.E., and Abrahams, L. cAMP and calcitonin gene-related peptide increase neurokinin1 receptor binding sites on neonatal rat spinal neurons. Neuroscience Abstracts, 24 (1998) 864.

24. Linden, D.R., Reutter, M.A., McCarson, K.E., and Seybold, V.S. Time-dependent changes in neurokinin3 receptor binding sites and messenger RNA concurrent with adjuvant-induced peripheral inflammation. Proceedings of the 9th World Congress on Pain (1999).

25. Amthauer, H.A., and McCarson, K.E. Gender-related differences in NK-1 receptor gene expression evoked by inflammatory nociception. Neuroscience Abstracts, 25 (1999) 680.

26. McCarson, K.E., and Enna, S.J. Nociceptive regulation of GABAB receptor gene expression in rat spinal cord. Neuroscience Abstracts, 25 (1999) 1974.

27. McCarson, K.E. Plasticity of neurokinin receptor gene expression: a contributor to persistent pain?. Regulatory Peptides, 86 (2000) 22.

28. Moran, J.M. Enna, S.J. and McCarson, K.E. Functional G-protein coupling of GABAB receptors in brain but not spinal cord of the rat. FASEB Journal (2000).

29. McCarson, K.E. Amthauer, H., and Moran, J.M. GABAB receptors regulate formalin-evoked inflammation and neurokinin-1 receptor gene expression in rat paw and spinal cord. Program No. 454.10, 2000 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2000. (Available online at: http://web.sfn.org)

30. Moran, J.M. Enna, S.J., and McCarson, K.E. Developmental regulation of GABAB receptor function in the rat spinal cord. Program No. 622.2, 2000 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2000. (Available online at: http://web.sfn.org)

31. Chronwall, B.M., Davis. T.D., Wolfe, S.E., McCarson, K.E., Low, M.J., Morris, S.J., and Enna, S.J. A mouse melanotrope clonal cell line (mIL-tsA58) constitutively expresses GABAB receptor heterodimers. Program No. 622.9, 2000 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2000. (Available online at: http://web.sfn.org)

32. Levant, B. and McCarson, K.E. D3 dopamine receptors in rat spinal cord: implications for sensory and motor function. ACNP (2000).

33. McCarson, K.E., Allen, A. and Cortright, D.N. Formalin- or adjuvant-induced peripheral inflammation alters neurokinin-1 receptor gene expression in the mouse. Program No. 57.4, 2001 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2001. (Available online at: http://web.sfn.org)

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34. Levant, B. and McCarson, K.E. D3 dopamine receptors in rat spinal cord: implications for sensory and motor function. Program No. 379.15, 2001 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2001. (Available online at: http://web.sfn.org)

35. Duric, V., Benoit, J. and McCarson, K.E. Hippocampal plasticity of neurokinin-1 receptor gene expression in rat models of stress and pain. FASEB Journal (2002).

36. Simon, M.P. and McCarson, K.E. Nociceptive sensitivity of the frog rana pipiens to vanilloids. Program No. 49.13, 2002 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. (Available online at: http://web.sfn.org)

37. Carlsten, J.A., Ryals, J.M., McCarson, K.E., and Wright, D.E. Effects of neurotrophin treatment on diabetes-induced hypoalgesia in mice. Program No. 757.5, 2002 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. (Available online at: http://web.sfn.org)

38. Allen, A.L. and McCarson, K.E. Estrogen modulates nociception-evoked brain-derived neurotrophic factor gene expression in the rat. Program No. 52.19, 2002 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. (Available online at: http://web.sfn.org)

39. Duric, V. and McCarson, K.E. Neurokinin-1 (NK-1) receptor and brain-derived neurotrophic factor (BDNF) gene expression in rat hippocampus during models of stress and pain. Program No. 866.15, 2002 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. (Available online at: http://web.sfn.org)

40. Allen, A.L. and McCarson, K.E. Differential regional expression of brain-derived neurotrophic factor (BDNF) and neurokinin-1 (NK-1) receptor genes in the rat brain is evoked by inflammatory nociception. Program No. 695.15, 2003 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2003. (Available online at: http://web.sfn.org)

41. Winter, M.K., Iloreta. S., and McCarson, K.E. Regulation of neurokinin-1 receptor (NK-1) function in the rat spinal cord dorsal horn by peripheral inflammation. Program No. 131.4, 2003 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2003. (Available online at: http://web.sfn.org)

42. Foster, V.A., Smith, P.G., Long, T.D., and McCarson, K.E. Topical morphine delays cutaneous wound healing. Program No. 657.3, 2003 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2003. (Available online at: http://web.sfn.org)

43. Duric, V. and McCarson, K.E. Differences in modulation of neurokinin-1 (NK-1) receptor and brain-derived neurotrophic factor (BDNF) gene expression in rat nociceptive sensory vs. affective systems during inflammatory pain. Program No. 695.14, 2003 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2003. (Available online at: http://web.sfn.org)

44. Winter, M.K. and McCarson, K.E. Neurokinin-1 receptor (NK-1) gene expression and function in limbic regions of the rat brain are decreased following peripheral inflammatory nociception. Program No. 747.16, 2004 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. (Available online at: http://web.sfn.org)

45. McCarson, K.E. and Rook, J.M. Cutaneous wound healing in the rat is delayed by local blockade of neurokinin-1 receptor activation. Program No. 290.1, 2004 Abstract Viewer

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and Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. (Available online at: http://web.sfn.org)

46. Allen, A.L. and McCarson, K.E. Estrogen potentiates the basal and nociception-evoked expression of brain-derived neurotrophic factor (BDNF) and the neurokinin-1 (NK-1) receptor in sensory systems. Program No. 61.8, 2004 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. (Available online at: http://web.sfn.org)

47. Duric, V. and McCarson, K.E. Effects of inflammatory pain on neurogenesis in the rat hippocampus. Program No. 747.17, 2004 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. (Available online at: http://web.sfn.org)

48. Reisman, S., Sands, S.A., McCarson, K.E., and Enna S.J. Effect of antidepressants on GABAB subunit expression and receptor function in rat spinal cord. FASEB Journal (2005)

49. Rook, J.M. and McCarson, K.E., Regulation of neurokinin-1 receptor gene expression in the amygdalo-hippocampal transition zone (AHi) following peripheral inflammation. 2005 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. (Available online at: http://web.sfn.org)

50. Belanus, S.J., Duric, V., McCarson, K.E. and Enna, S.J. Evidence that GABAB(1a) may influence cell function independent of its role as a GABAB receptor subunit 2005 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. (Available online at: http://web.sfn.org)

51. Winter, M.K., Gordon, S.B., and McCarson, K.E. Intrathecal paclitaxel administration blocks NK-1 receptor internalization and enhances formalin-evoked hyperalgesia. 2005 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. (Available online at: http://web.sfn.org)

52. Duric, V. and McCarson, K.E. Effects of analgesic or antidepressant pretreatments on the hippocampal neurokinin-1 (NK-1) receptor and brain-derived neurotrophic factor (BDNF) gene expression in rat models of inflammatory pain. 2005 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. (Available online at: http://web.sfn.org)

53. Allen, A.L. and McCarson, K.E. Estrogen Increases Neurokinin-1 Receptor (NK-1) Protein and G-Protein Activation in the Amygdala During Persistent Inflammation. 2005 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. (Available online at: http://web.sfn.org)

54. Winter, M.K. and McCarson, K.E. Does caveolin-enriched lipid raft function regulate nociceptive neurokinin-1 receptor activation in the rat spinal cord?. 2006 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2006. (Available online at: http://web.sfn.org)

55. Rook, J.M. and McCarson, K.E. Topical morphine application delays cutaneous wound healing in the rat by local blockade of peripheral tachykinin release. 2006 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2006. (Available online at: http://web.sfn.org)

56. Ralya, A. and McCarson, K.E. Do endogenous male gonadal hormones contribute to sex differences in nociception in the rat? 2006 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2006. (Available online at: http://web.sfn.org)

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57. McCarson, K.E., Winter, M.K., and Gordon, S.B. Central and peripheral modulatory effects of estrogen on spinal nociceptive activation in the rat. 2006 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2006. (Available online at: http://web.sfn.org)

58 Liverman, C.S., Brown, J., McCarson, K.E., Klein, R.M., and Berman, N.E. Estrogen and inflammation induce Erk activation in trigeminal neurons and facial hyperalgesia. 2006 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2006. (Available online at: http://web.sfn.org)

59. McCarson, K.E., Persistent Pain, the Hippocampus, and Depression – Mechanistic Links. American Pain Society Annual Meeting. Washington, D.C., 2007.

60. Ozias, M.K., McCarson, K.E., and Levant, B. Depletion of brain docosahexaenoic acid content and reproductive status affect expression of brain-derived neurotrophic factor in the female rat. 2007 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2007. (Available online at: http://web.sfn.org)

61. Rook, J.M. and McCarson, K.E. Capsaicin-induced cutaneous sensory denervation produces morphine-like delays in wound closure. 2007 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2007. (Available online at: http://web.sfn.org)

62. Ralya, A. and McCarson, K.E. Is spinal nociceptive activation modulated by an estrogen surge? 2007 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2007. (Available online at: http://web.sfn.org)

63. Liverman, C.S., McCarson, K.E., Brown, J., Klein, R.M., and Berman, N.E.J. Estrogen increases orofacial pain through ERK activation in the trigeminal ganglion: evidence for a peripheral mechanism of secondary hyperalgesia. 2007 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2007. (Available online at: http://web.sfn.org)

64. Liverman C.S.; Brown J.; McCarson K.E.; Stucky N.L.; and Berman N.E. Potential Role of a Novel Estrogen Receptor, GPR30, in Hormone-Related Headache. (2008) Program Abstracts, Headache: The Journal of Head and Face Pain 48 (s1), S7.

65. Ralya, A. and McCarson, K.E. Estrogen enhances inflammatory nociception, but is this through a spinal mechanism? 2008 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2008. (Available online at: http://web.sfn.org)

66. McCarson, K.E. and Ralya, A. Estrogen enhances inflammatory nociception without modifying spinal FOS expression. The Neurobiology of Pain and Analgesia (C2) Keystone Symposium, 2009.

67. McCarson, K.E. and Ralya, A. Supraspinal markers of nociception in the formalin pain model: Modulation by extrogen? 2009 Abstract Viewer and Itinerary Planner. Chicago, IL: Society for Neuroscience, 2009. (Available online at: http://web.sfn.org)

68. Enna, S.J., Ghose, S, Winter, M. K., McCarson, K.E., and Tamminga, C.A. GABAB receptors and major depression: Postmortem studies. British Pharmacology Society Winter Meeting, London, UK; Proceedings of the British Pharmacology. Society, 2009.

69. Stucky, N.L., Gregory, E., Winter, M., He, Y., McCarson, K.E., and Berman, N.E.J. Sex Differences and Stimulus Effects on Sensory and Motor Behaviors in a Rat Model of

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Migraine. 52nd Annual Scientific Meeting for the American Headache Society, (2010) Los Angeles, CA.

70. Stucky, N.L., Gregory, E., He, Y., McCarson, K.E., and Berman, N.E.J. Expression of CGRP and the CGRP Receptor in a Rat Model of Migraine. 52nd Annual Scientific Meeting for the American Headache Society, (2010) Los Angeles, CA.

71. McCarson, K.E. and Ralya, A. Effects of estrogen on inflammatory nociception-evoked pain-related behaviors: Studies using the force-plate actimeter. 2010 Abstract Viewer and Itinerary Planner. San Diego, CA: Society for Neuroscience, 2010. (Available online at: http://web.sfn.org)

72. Sharma, N.K., McCarson, K.E., Van Dillen, L., Brooks, W., Khan, T., Wilson, s., Bani-Ahmed, A., and Cirstea, C. 1H-MRS Cortical measurements in chronic low back pain. 2010 Abstract Viewer and Itinerary Planner. San Diego, CA: Society for Neuroscience, 2010. (Available online at: http://web.sfn.org)

73. McCarson, K.E., Stucky, N.L., Winter, M., Gregory, E., and Berman, N.E.J. Quantitative assessment of photophobia and phonophobia in a rat behavioral model of migraine headache. 2011 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2011. (Available online at: http://web.sfn.org)

74. Sharma, N.K., Khan, T., Braun, T., Lentz, A., McCarson, K.E., Van Dillen, L., Brooks, W., Bani-Ahmed, A., Popescu, A., Wilson, S.,and Cirstea, C. Effects of exercise training on cortical biochemistry in chronic low back pain. 2011 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2011. (Available online at: http://web.sfn.org)

75. Corder, G., Donahue, R.R., Winter, M.K., Chen, W, McCarson, K.E., Marvizon, J.C., and Taylor, B.K. Activation of postsynaptic NPY Y1 and presynaptic Y2 receptors reduce spinal nociceptive transmission. 2011 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2011. (Available online at: http://web.sfn.org)

76. Corder, G., Doolen, S., Winter, M.K., McCarson, K.E., and Taylor, B.K. Opioid inhibition of NMDA-dependent spinal sensitization persists long after the resolution of inflammatory hyperalgesia. 14th World Congress on Pain. Milan, Italy, International Association for the Study of Pain, 2012.

77. Corder, G, Doolen, S., Winter, M., McCarson, K.E., and Taylor, B. After resolution of inflammation-induced hypersensitivity, spinal μ-opioid receptors tonically inhibit an NMDA receptor-dependent sensitization. 2012 Abstract Viewer and Itinerary Planner. New Orleans, LA: Society for Neuroscience, 2012. (Available online at: http://web.sfn.org)

78. McCarson, K.E., Steenhard, B.M., St. John, P.l., Stroganova, L., Zelenchuk, A., Winter, M.K., Durham, D. Fowler, S.C., and Abrahamson, D.R. Abnormal locomotor behavioral phenotype in a transgenic mouse model of human Laminin α5 expression. 2012 Abstract Viewer and Itinerary Planner. New Orleans, LA: Society for Neuroscience, 2012. (Available online at: http://web.sfn.org)

79. McCarson, K.E., Winter, M.K., Gregory, E., and Berman, N.E.J. Quantitative assessment of facial allodynia in a rat behavioral model of migraine headache. 2012 Abstract Viewer and Itinerary Planner. New Orleans, LA: Society for Neuroscience, 2012. (Available online at: http://web.sfn.org)

80. Krizsan-Agbas, D., Winter, M.K., Eggimann, L.S., Meriwether, J., Smith, P.G., Berman, N. E. and McCarson, K.E., Quantitative walking gait analyses reveal differential behavioral

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deficits and recovery across graded severities of a spinal injury model. Neurotrauma 2013. Nashville, TN. Society for Neurotrauma, 2013.

81. McCarson, K.E., Krizsan-Agbas, D., Winter, M.K., Eggimann, L.S., Meriwether, J., Berman, N. E., and Smith, P.G. Behavioral assessment of gait deficits enhanced by using DigiGait™ analysis and integration of the step cycle in a graded model of spinal cord injury. 2013 Abstract Viewer and Itinerary Planner. San Diego, CA: Society for Neuroscience, 2013. (Available online at: http://web.sfn.org)

82. Tague, S.E., Winter, M.K., Sullivan, G.G., McCarson, K.E., Drisko, J.A., and Smith, P.G. Vitamin B6 deficiency leads to mechanical insensitivity and sensory denervation. Midwest Regional Pain Interest Group. Cincinnati, OH, 2013.

83. Vermeer, L.M.M., Gregory, E., McCarson, K.E., and Berman, N.E. Bisphenol A Exposure Augments Migraine-Like Behavior in a Multibehavioral Model of Migraine in Rat. Midwest Regional Pain Interest Group. Cincinnati, OH, 2013.

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86. Tague, S., Winter, M., Sanli, N., Lunte, C., McCarson, K.E., Drisko, J., and Smith, P.G. Dietary vitamin B6 differentially modulates cutaneous sensitivity in diabetic and non-diabetic mice, and affects peripheral sensory axon morphology and spinal cord neurotransmitter content. 2015 Abstract Viewer and Itinerary Planner. Chicago, Il.: Society for Neuroscience, 2015. (Available online at: http://web.sfn.org)

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