from our files

KEEPING DOWN THE LIPID LEVELS - A look at the drugs available (contd)

Clofibrate

o Clinical use Clofibrate in type II hyperlipoproteinemia. Ditzel, J. et al. Acta Medica

Scandinavica 200: 55 (1976)

A clofibrate controlled trial of gemfibrozil in the treatment of hyperlipidaemias. Tuomilehto, J. et al. Proceedings of the Royal Society of

Medicine 69: 38 (Suppl. 2, 1976)

Gemfibrozil and clofibrate in the treatment of hyperlipidaemias. A comparative trial. Eisalo, A. et al. Proceedings of the Royal Society of

Medicine 69: 44 (Suppl. 2. 1976) Gemfibrozil treatment: a comparison with clofibrate. Howard. A.N. et al.

Proceedings of the Royal Society of Medicine 69: 88 (Suppl. 2, 1976)

Management of type IV hyperlipoproteinemia. Smith. LK. etal. Annals of

Internal Medicine 84: 22 (1976) Clinical experimentation with RU 19.538 (DabicaD calcium clofibrate.

Pauchant. M. et al. Lille Medical 21: 24 (Supp!. I, 1976)

Treatment of hyperlipidaemia. A comparison of the efficacy of clofibrate and

~-pyridylcarbinol. Wolfram, G. et al. Deutsche Medizinische

Wochenschrift 101: 76 (J 976) Results with an association of pyridinol carbamate and clofibrate in 26 cases

of lower extremity and coronary atherosclerosis. Valiansi, M. et al.

Minerva Cardioangiologica 24: 148 (1976) One-year trials with halofenate, clofibrate, and placebo. Dujovne, C.A. et al.

Clinical Pharmacology and Therapeutics 19: 352 (J 976)

Treatment of diabetic-retinopathy with doxium-clofibrate. Freyler, H. et al.

Klinische MonaLsblaetter fuer Augenheilkunde 168: 377 (J 976)

Treatment of hyperlipoproteinaemia types lIa. lib. IV and V with a

combination of clofibrate and inositol nicotinate. Wilke, H. et al. Deutsche

Medizinische Wochenschrift 101: 401 (J 976)

Comparative study between clofibrate and a new hypolipidemic drug. Procetofene (38 patients). Fromentin. M. et al. Gazette Medicale de France

83: 1459 (1976)

Potentiation of hypoglycemic response to intravenous tolbutamide by clofibrate. Ferrari. C. et al. New England Journal of Medicine 294: 1184 (1976)

Halofenate in the treatment of type II hyperiipoproteinemia - double blind

comparison with clofibrate. Rees. E.D. et al. Atherosclerosis 24: 537 ( 1976)

Treatment of primary hyperlipoproteinemia. N 041 in comparison to

clofibrate. Gaertenr. U. et al. Muenchener Medizinische Wochenschrift

118: 1127(1976) C1ofibrate-therapy-problems of hyperlipemia in haemodialysis-treated

patients. Wessels. G. et al. Die Medizinische Welt 27: 2278 (1976)

A two-year crossover therapeutic trial with halofenate and clofibrate.

Dujovne, CA. et al. American Journal of the Medical Sciences 272: 277 ( 1976)

Combination of clofibrate and phenformin in the treatment of endogenous

hypertriglyceridaemia. Vogelberg, K.H. Deutsche Medizinische

Wochenschrift 101: 1868 (1976) The effect of clofibrate (Atromid) on intravenous tolbutamide. oral and

intravenous glucose tolerance tests. Clinical observation and trial of

hypoglycaemic effects of clofibrate. Csoegoer. S.1. et al. Clinical Trials

Journal 14: 15 (J 977) Long-term treatment with clofibrate (Atromid). Observation of plasma­

fibrinogen and serum-lipids. Ohtani. Y. Clinical Trials Journal 14: 106

(1977) The use of clofibrate in the treatment of hard exudates. using a reduced but

prolonged dosage over several years. Dome. P.A. Archives

D'Ophtalmologie 37: 393 (J 977) Clinical effect of cholesolvin in hyperlipemia. Nakamura. N. et al. Japan

Medical News 110: 10 (1977)

Clinical trial on the cinnarizine-c1ofibrate association. Carvalho, M.R. et a!.

Revista Brasileira de Medicina 34: 73 (1977) Effect of clofibrate on postheparin plasma triglyceride lipase activities in

patients with hypertriglyceridemia. Nikkilae, E.A. et al. Metabolism.

Clinical and Experimental 26: 179 (1977)

Colestipol. clofibrate. and phytosterols in combined therapy of hyperiipidemia. Grundy, S.M. et al. Journal of Laboratory and Clinical

Medicine 89: 354 (1977) Comparison of clofibrate with halofenate in diabetics with hyperlipidaemia.

Krut. L.H. et al. South African Medical Journal 51: 348 (1977)

Hypolipidemic effect of tibric acid. Bielmann. P. et a!. International Journal of

Clinical Pharmacology and Biopharmacy 15: 166 (1977) Clofibrate in hemodialyzed patients. Kurokawa, K. New England Journal of

Medicine 296: 942 (1977) Treatment of primary hyperlipoproteinemias of type lib and IV with

butylbiguanide and clofibrate. Koschinsky, Th. et al. Munchener

Medizinische Wochenschrift 119: 701 (1977)

Clofibrate, nicotinic acid and hexanicotinic acid inositol in one drug (Duplinal@)fortreatment of hyper lip oproteinemi as. Schmulling. R-M. et

al. Artery 3: 265 (I 977) Effectiveness of halofenate versus clofibrate in hyperlipoproteinemia: a one­

year follow-up study. Moncada Lorenzo, E. et al. Current Therapeutic

Research 22: 147 (1977) Secholex and clofibrate in type II hyperlipoproteinaemia. Howard, A.N. et al.

Medikon6: 3(1977) Combination of clofibrate and phenformin in the treatment of endogenous

hypertriglyceridaemia in a randomized cross-over design. Koschinsky. T.

et al. Diabetologia 13: 410 (1977) The effect of treatment with clofibrate on hepatic triglyceride and lipoprotein

lipase activities on post heparin plasma in male patients with hyperlipoproteinemia. Short communications. Boberg. J. et al.

Atherosclerosis 27: 499 (1977) Effect of clofibrate on lipoprotein-lipids in patients with type IV

hyperlipoproteinaemia. Weisweiler. P. et al. Klinische Wochenschrift 55:

791 (1977)

Reduction of myocardial reinfarction by the combined treatment with clofibrate and nicotinic acid. Carlson. L.A. et al. Atherosclerosis 28: 81 (1977)

Clofibrate treatment of hyperlipidemia in chronic renal failure. di Giulio. S. et

al. Clinical Nephrology 8: 504 (1977) Effects of clofibrate, nicotinic acid and diet on the properties of the plasma

lipoproteins in a subject with type III hyperiipoproteinemia. Patsch, JR. et

al. American Journal of Medicine 63: 100 I (1977)

Long-term trial with colestipol plus clofibrate in familial hypercholesterolemia. Fellin, R. et al. Atherosclerosis 29: 241 (1978)

Combination or monotherapy of hyperlipoproteinemia types lib, IV. V with

clofibrate and m-inositolnicotinate or c10fibrinic acid. SchwartzkopfL W.

et al. Medizinische Klinik 73: 231 (1978) Investigation of the antihyperlipemic activity of an association of clofibrate

and extractive mucopolysaccharide complex. Saba, P. et al. Current

Therapeutic Research 23: 455 (J 978)

Halofenate

o Pharmacodynamics

Comparison of clofibrate and halofenate: Mechanism of hypotriglyceridemic

action. Cenedella, RJ. et al. Federation Proceedings 34: 789 (197 5)

Drugs affecting the synthesis of glycerides and phospholipids in rat liver. The

effects of clofibrate, halofenate, fenlluramine. amphetamine, cinchocaine. chlorpromazine, demethylimipramine, mepyramine and some of their

derivatives. Brindley, D.N. et al. Biochemical Journal 148: 46 t (I975)

The metabolic spectrum of halofenate. Ryan, J.R. International Journal of Clinical Pharmacology and Biopharmacy 12: 239 (1975)

INPHARMA 24th June. 1978 p19

Efficacy and interactions of oxandrolone. halofenate and clofibrate in a

factorial study on experimental acute nephrotic hyperlipidemia. Schapel.

G J. et al. Journal of Pharmacology and EXperimental Therapeutics 194:

274 ([975)

Hepatic triglyceride Iipases: Effect of clofibrate and halofenate. Cenedella. R.1. Pharmacologist 18: 158 (1976)

Halofenate and clofibrate: mechanism of hypotriglyceridemic action in the rat. Cenedella. RJ . et al. Journal of Lipid Research 17 : 156 ([976)

The effect of halofenate and clofibrate on aggregation and release of serotonin

by human platelets. Lin. C. Y. et al. Life Sciences 18: 563 ([ 976)

The effect of halofenate or halofenate free acid on human, rat and guinea pig

platelet aggregation. Minsker, D.H. et al. Thrombosis and Haemostasis 35:

358 ([976)

Halofenate: A potent inhibitor of normal and hypersensitive platelets. Colman,

R.W . et al.lournal of Laboratory and Clinical Medicine 39: 282 ([976)

Hepatic triglyceride lipases - effect of clofibrate and halofenate. Cenedella,

R.J . Biochemical Pharmacology 25: 2657 (1976)

Changes in serum thyrotropin (TSH) in man during halofenate administration.

Davis, P.J. eta1. Journal of Clinical Endocrinology and Metabolism 43:

873 (1976)

Studies on the mechanism of action of halofenate. Mandel, L.R. Lipids 12: 34 (1977)

Halofenate - a tool for evaluating the role of platelet lipids in platelet

function. Akbar. H. et al. Clinical and Experimental Pharmacology and

Physiology 4: 495 (1977)

Effect of halofenate on the serum binding of phenytoin. Karch . F.E. et al.

British Journal of Clinical Pharmacology 4: 625 (1977)

Influence of 2-acetoamidoethyl (p-chlorophenyl) (m-trifluoromethylphenoxy)

acetate (halofenate) on hepatic drug metabolism in retired breeder rats.

Anthony . L.E. et a1. Proceedings of the Society for Experimental Biology

and Medicine 154: 142 (\ 977)

The effect of halofenate-free acid on aggregation - the release reaction.

coagulant· activity , and lipid metabolism of human platelets. Huzoor­

Akbar. A.N.G. Thrombosis and Haemostasis 38: 612 (\ 977)

Effects of halofenate on glucose tolerance in patients with

hyperlipoproteinemia. Feldman. E. B. et al. Journal of Clinical

Pharmacology 18: 241 (1978)

o And clinical trials A one year double blind study of the effect of halofenate and clofibrate in

patients with hyperlipoproteinemia. Rottiers. R. et a1. Acta Clinica Belgica

30: 398 ([ 975)

Long-term efficacy of halofenate on serum triglyceride levels. Aronow, W.S.

et al. Current Therapeutic Research 18: 855 (! 975)

Halofenate: its selection and trial as a primary uricosuric agent. Bluestone. R.

etal. Arthritis and Rheumatism 18: 859([975)

A double-blind study comparing halofenate with probenecid in gout. Bluhm.

G.B. et al. Arthritis and Rheumatism 18: 388([ 975)

One-year trials with halofenate. clofibrate. and placebo. Dujovne. C.A. et al.

Clinical Pharmacology and Therapeutics 19: 352 ([ 976)

Lipid-lowering agents in diabetics with hyperlipidaemia. Krut. L.H. et aI. South African Medicallournal50: 1001 (1976)

Halofenate in the treatment of type II hyperlipoproteinemia - double blind

comparison with clofibrate. Rees. E.D. et al. Atherosclerosis 24: 537

([ 976)

A two-year crossover therapeutic trial with halofenate and clofibrate.

Dujovne, C.A. eta!. American lou rna! of the Medica! Sciences 272: 277 ([ 976)

On the therapy of hyperlipidemia and hyperuricemia with 2-

acetoamidoethyl-(4-chlorophenyl}-(trifluoromethylphenoxy)-acetate

(halofenate), a derivate of clofibrate. Keller. Ch. et al.

Arzneimittelforschung 26: 2221 (1976)

Comparison of clofibrate with halofenate in diabetics with hyperlipidaemia.

Krut. L. H. et al. South African Medical Journal 51: 348 ([ 977)

Halofenate. Castaner. J. et al. Drugs of the Future 2: 452 (I 977)

Effectiveness of halofenate versus clofibrate in hyperlipoproteinemia: A one­

year follow-up study. Moncada Lorenzo, E. et al. Current Therapeutic

Research 22: 147 (I 977)

Effects of halofenate and probenecid on serum lipids and uric acid in

hyperlipidemic. hyperuricemic adults. Bassett. D .R. et al . Clinical

Pharmacology and Therapeutics 22: 340 (1977)

Neomycin

Treatment of severe and mild hypercholesterolaemia with probucol and

neomycin. (Proc. of an international symposium at Swedish Society of

Medical Sciences. Stockholm. 8-9 October 1974). Miettinen. T.A. et al.

Postgraduate Medical Journal 51 : 7 i (Suppl. 8. 1975)

Effects of neomycin on absorption. synthesis. and/or flux of cholesterol in

man. Sedaghat. A. et al. Journal of Clinical Investigation 55: 12 (1975)

A comparative study of the effects of cholestyramine and neomycin in the

treatment of type II hyperlipoproteinaemia. Schade. R. W .B. et al. Acta

Medica Scandinavica 199: 175 ([ 976)

Effects of colestipol hydrochlorides and neomycin sulfate on cholesterol

turnover in the rat. Phillips. W.A . el aJ. Lipids 12: 10 (J 977)

Selection of multiresistant coliforms by long-term treatment of

hypercholesterolaemia with neomycin. Valtonen. M. V. et al. British

Medical Journal I: 683 (1977)