Karen H. Rothenberg, J.D., M.B.A.Karen H. Rothenberg, J.D., M.B.A.Dean and Marjorie Cook Professor of Law at the University of Maryland School Dean and Marjorie Cook Professor of Law at the University of Maryland School of Law and Chair, Maryland Stem Cell Research Commissionof Law and Chair, Maryland Stem Cell Research Commission

Maryland Stem Cell Research CommissionMaryland Stem Cell Research Commission

www.mscrf.org May, 28 2009

GBC Bioscience GBC Bioscience Speaker SeriesSpeaker Series

The Maryland Stem Cell Research Act of 2006 The Maryland Stem Cell Research Act of 2006

Purpose: The purpose of the Act is to promote state-funded stem cell research and cures through grants and loans to public and private entities in the State.

Commission: Established as an independent unit within the Maryland Technology Development Corporation (TEDCO), the Commission will establish criteria, standards and requirements to ensure that stem cell research financed by the newly established Maryland Stem Cell Research Fund complies with state law.

Summary: To date, $56 million and 141 research grants have been funded in the first three years and our fourth year of the program with a budget of $15.4 million.

The Maryland Stem Cell Research Act of 2006 The Maryland Stem Cell Research Act of 2006

Human Stem Cell: Human stem cell is a human cell that has the ability to:

(1) Divide indefinitely;(2) Give rise to many other types of specialized cells(3) Give rise to new stem cells with identical potential.

Including the creation of new stem cell lines.

Eligibility: All Maryland based organizations of all types are eligible for the Grants. Such organizations include public and private, for profit and nonprofit, universities, colleges, research institutes, companies, medical centers and others.

Diseases and ConditionsDiseases and Conditions

Blood Diseases; Schizophrenia; Neural; Spinal Cord Injury; Central Nervous System; Genetic Development; Burn wounds; Amyotrophic lateral sclerosis; Multiple peripheral nerve regeneration; Pancreas; Neurodegenerative Diseases; Acute myeloid leukemia; Multiple leukemia; Brain Tumor; Development; Lungs; Multiple Cancer; Coronary; Heart disease; Myocardial infarction; Molecular biology; Type 1 Diabetes; Human pluripotent stem cell; Vascular; Neonatal Stroke; Retinal degenerative; Generate insulin-producing beta-cells; Neural hematopoiesis; Human erythropoiesis; Acute Lymphocytic Leukemia; Vascular diseases; Brain pathology; Mesenchymal stem Cell Differentiation; Ewing Sarcoma; Muscular dystrophy; Chronic pancreatitis, Pancreatic adenocarcinoma; Glioblastoma; Parkinson's Disease; Cystic Fibrosis; Chemo-resistance; Bone; Gaucher's; Breast Cancer; Osteoarthritis; Transplantation; Paroxysmal Nocturnal Hemoglobinuria (PNH); Liver; Alzheimer's Disease; Peripheral Arterial Disease; Prostate Cancer

Investigator-Initiated Research Grants Investigator-Initiated Research Grants

Investigator-Initiated Research Grants is soliciting applications for Investigator with preliminary data supporting the grant application with maximum amount of $300,000 a year, for up to five years.

Exploratory Research Grants Exploratory Research Grants

Exploratory Research Grants is soliciting applications for Exploratory Research, which are designed for investigators who are new to the stem cell field and for exploratory projects without preliminary data with maximum amount of $100,000 a year, for up to two years.

Post-doctoral Fellowship GrantsPost-doctoral Fellowship Grants

Post-doctoral Fellowship Grants is soliciting nationwide applications from exceptional post-doctoral fellows who wish to conduct research on human stem cells in the State of Maryland with maximum support of $55,000 a year, for up to two years.

Funding OverviewFunding Overview

Funding started in FY2007 with $15 Million and funded 24 research projects:

– Investigator-Initiated (7 from 41)– Exploratory (17 from 45)

In FY2008 we funded $23 Million and funded 58 research projects:

– Investigator-Initiated (11 from 33)– Exploratory (32 from 64)– Post-Doctoral Fellowship (15 from 24)

Funding Overview ContinuedFunding Overview Continued

In FY2009 we funded $18.9 Million in 59 Awards:– Investigator-Initiated Research Grants (6 from 40)– Exploratory Research Grants (32 from 70)– Post-Doctoral Grants (21 from 40)

In FY2010 we have a budget of $15.4M

Number of Applications and Awards

Fiscal Year

MSCRF Budget in Millions

2007 2008 2009 2010

ApplicationsApplications, , GrantsGrants and and budgetbudget Summary Summary

FY2009 summary of awardsFY2009 summary of awards

Awards in Numbers

FY2009 summary of awards Cont.FY2009 summary of awards Cont.

Awards in $

FY2009 summary of awards Cont.FY2009 summary of awards Cont.

Stem Cell Type

FY2009 summary of awards Cont.FY2009 summary of awards Cont.

Basic & Translational Research

Strategic QuestionsStrategic Questions

Enhancing private-public partnerships Leveraging State and Federal grants Balancing research and capital