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Ovarian Cancer

SMF OBSTETRI-GYNECOLOGY

FK UNUD / RSUP SANGLAH2!"

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Ri#$ %ac&'r# %'r Ovarian &()'r#

N(**i+ari&, an *'. +ari&,

0i&e race

Fa)i*, 0i#&'r,

Gene&ic )(&a&i'n# BRCA! an BRCA2 1#er'(# c,#&aen'carcin')a# E#&i)a&e ri#$ '% 'varian cancer in .')en 3earin4 BRCA!

'r BRCA2 )(&a&i'n# i# 2 &' 5 6 3, &0e a4e '% 7 ,ear#

86 HER2 4ene 'vere9+re##i'n

+:8 )(&a&i'n# +:8 )(&a&i'n# are %'(n in :6 '% 'varian cancer#

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Ovarian Cancer Ri#$ Fac&'r#;Decrea#e Ri#$

Fac&'r Re*a&ive Ri#$Pre4nancie#

N'ne !

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Ovarian Cancer Ri#$ Fac&'r#;Increa#e Ri#$ A4e

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Ovarian Cancer Ri#$ Fac&'r#;Increa#e Ri#$

Fac&'r Re*a&ive Ri#$

Hx of Breast CancerN'ne !Per#'na* Hi#&'r, !Hx of Ovarian Cancer

N'ne !

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xamples of Tumour Suppressor Genes

 APC Colon Cancer

BRCA1   Breast & Ovarian Cancer

BRCA2 Breast Cancer

NF1 Neurobromatosis (malignantneurobromas)

TP53 Brain Breast Colon !iver !ungcarcinomas

RB "etinoblastoma Sarcomas Bla##er

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B"C ' B"C Cromosome

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Pa&0'4ene#i# Ovarian Cancer

!< M(&a#i K-Ra# 'nc'4en

Ter*i3a& a*a) re4(*a#i #i$*(# #e*

In0i3i#i #e* a+'+&'#i#Me)ic( +r'*i%era#i #e*

2< M(&a#i 4en BRCA

8< De N'v' 1CIC# i a*a) #&r')a'vari()  #+'n&ane'(# )(&a#i +:8

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9/26$illiam G*necolog* n# e#ition

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BRCA ! an BRCA 2 F(nc&i'n

T()'r #(++re##'r 4ene# Re4(*a&e n'r)a* ce** 4r'.&0 an

+r'*i%era&i'n

C'(n&erac& #&i)(*a&'r, e%%ec '%'nc'4ene#

P*a, a r'*e in DNA re+air

In&erac& .i&0 RAD:!? a $n'.n DNAre+air +r'&ein

 @Care&a$er 4ene# 

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0ic0 ce** 'e# cancer ari#e in

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0' c*a##i%ica&i'n '% 'varian &()'r#

S(r%ace e+i&0e*ia*-#&r')a* &()'r#

Se9 c'r-#&r')a* &()'r#

Ger) ce** &()'r#

Mi9e 4er)-ce** #e9 c'r-#&r')a* &()'r#

T()'r# an re*a&e *e#i'n# '% &0e re&e 'varii Mi#ce**ane'(# &()'r# an &()'r *i$e *e#i'n#

L,)+0')a# an *e$ae)ia#

Sec'nar, &()'r# '% &0e 'var,

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S(r%ace e+i&0e*ia*-#&r')a*&()'r#

Ser'(# &()'r#

M(cin'(# &()'r#

En')e&r'i &()'r# C*ear ce** &()'r#

Tran#i&i'na* ce** &()'r#

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Ser'(# &()'r#

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Ser'(# &()'r#

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M(cin'(# &()'r#

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M(cin'(# &()'r#

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En')e&ri'i &()'r#

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C*ear ce** aen'carcin')a

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