Rotavirusby Sinead Mc Coy and Kanchan Parsad

Virus classification and identification

• Serological tests

Family Reoviridae

Subfamily Sedoreovirinae

Genus Rotavirus

Group III double stranded RNA

Species Rotavirus A, B, C, D, E, F, G, H

History of Rotavirus

•In 1973 the virus was identified.

•Named by Flewett in 1974.

•Most common cause of severe gastroenteritis in infants and young children.

•Universal

Virus shape and genome structure

The rotavirus disease

•The disease causes acute gastroenteritis usually in infants and small children.

•Symptoms include watery diarrhea, vomiting, fever and abdominal pain.

•It is possible to become infected by the virus more than once.

•The route of transmission for the virus is the fecal – oral route.

Replication Cycle

Prevention and Treatment

Good hygiene

Rotavirus vaccines

References•Centers for Disease Control and Prevention. Epidemiology and Prevention of Vaccine-Preventable Diseases. Atkinson W, Wolfe S, Hamborsky J, eds. 12th ed., second printing. Washington DC: Public Health Foundation, 2012.

•Flewett TH, Woode GN (1978). "The rotaviruses". Arch. Virol. 57 (1): 1–23. doi:10.1007/BF01315633. PMID 77663.

•Matthews RE (1979). "Third report of the International Committee on Taxonomy of Viruses. Classification and nomenclature of viruses". Intervirology 12 (3–5): 129–296. doi:10.1159/000149081. PMID 43850.

•www.bmb.oxfordjournals.org - rotavirus and rotavirus vaccines

•www.cdc.gov - rotavirus/ home/ gastroenteritis/ CDC

•www.who.int - programmes/international travel and health/ disease information/ rotavirus

•www.viralvone.expasy.org

•M K Estes, J Cohen. ‘‘Rotavirus gene structure and function’’ Microbiol Rev. 1989 December; 53(4): 410–449.PMCID: PMC372748

vaccine images from: http://web.stanford.edu/group/virus/reo/2008/reoviridae.html