UNIVERSITAS INDONESIA

Peran Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

pada Adenokarsinoma Paru Stadium Lanjut

REFERAT

ANINDIA LARASATI1206234540

PEMBIMBINGDr. Ceva W Pitoyo, SpPD KP KIC

PROGRAM PENDIDIKAN DOKTER SPESIALISILMU PENYAKIT DALAM

FAKULTAS KEDOKTERAN UNIVERSITAS INDONESIAJAKARTA

JANUARI 2015

i

LEMBAR PENGESAHAN

Referat

Peran Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

pada Adenokarsinoma Paru Stadium Lanjut

Oleh:

Dr. Anindia Larasati

PPDS Ilmu Penyakit Dalam Tahap 2

NPM 1206234540

Telah disetujui untuk dipersembahkan di RSUPN Cipto Mangunkusumo

Pada bulan Januari 2015

Pembimbing

Dr. Ceva W Pitoyo, SpPD KP KIC

ii

PERNYATAAN BEBAS PLAGIARISME

Saya yang bertanda tangan dibawah ini dengan sebenarnya menyatakan bahwa karya ilmiah

berupa sari pustaka berikut ini dengan judul:

Peran Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

pada Adenokarsinoma Paru Stadium Lanjut

Saya susun tanpa tindakan plagiarisme sesuai dengan peraturan yang berlaku di Universitas

Indonesia.

Jika di kemudian hari ternyata saya terbukti melakukan tindakan yang dapat digolongkan

sebagai plagiarisme atas karya ilmiah ini, saya akan bertanggung jawab sepenuhnya dan

menerima sanksi yang dijatuhkan oleh Universitas Indonesia kepada saya.

Jakarta, Januari 2015

Anindia Larasati

1206234540

iii

DAFTAR ISI

Judul.....................................................................................................................................i

Lembar Pengesahan............................................................................................................. ii

Pernyataan bebas plagiarisme..............................................................................................iii

Daftar isi.............................................................................................................................. iv

Daftar gambar ..................................................................................................................... v

Daftar tabel.......................................................................................................................... vi

BAB I Pendahuluan............................................................................................................. 1

BAB II Tinjauan Pustaka.....................................................................................................3

2.1 Adenokarsinoma : Definisi................................................................................ 3

2.2 Epidemiologi......................................................................................................3

2.3 Patogenesis.........................................................................................................3

2.4 Tipe histologis ...................................................................................................4

2.5 Staging............................................................................................................... 5

2.6 Diagnosis........................................................................................................... 6

2.7 Biologi molekuler.............................................................................................. 7

2.8 Tatalaksana........................................................................................................ 7

2.9 Epidermal Growth Factor Receptor...................................................................8

2.10 Diagnosis abnormalitas EGFR........................................................................ 10

2.10.1 DNA sequencing...........................................................................................11

2.10.2 Imunohistokimia........................................................................................... 11

2.10.3 Analisis polymerase chain reaction.............................................................. 11

2.11 Respon terhadap EGFR TKI............................................................................11

2.12 Epidermal growth factor receptor inhibitor..................................................... 11

2.12.1 Gefitinib........................................................................................................12

2.12.2 Erlotinib........................................................................................................ 12

2.13 Guidelines..........................................................................................................14

2.13 Efek samping....................................................................................................15

BAB III Kesimpulan............................................................................................................16

Daftar Pustaka......................................................................................................................17

iv

DAFTAR GAMBAR

Gambar 1. Hasil biopsi adenokarsinoma paru.................................................................... 4

Gambar 2. Algoritme diagnosis adenokarsinoma............................................................... 6

Gambar 3. Jalur sinyal molekuler EGFR.............................................................................9

Gambar 4. Frekuensi mutasi onkogen pada adenokarsinoma......................................... 10

v

DAFTAR TABEL

Tabel 1. Frekuensi insidens kanker rongga toraks.............................................................. 3

Tabel 2. Prevalensi mutasi EGFR pada adenokarsinoma.................................................. 7

vi