INDEX

Volume 242, July-September, 1987

Abhold, R. H., Sullivan, M. J., Wright, J.

W. and Harding, J. W.: Binding, deg-radation and pressor activity of

angiotensins II and III after amino-peptidase inhibition with amastatinand bestatin, 957

Abiko, Y., see Matsumura, N., 1114

Accessory cells, antigen presentation,benzo(a)pyrene-induced modulation

(mice), 399

Acetazolamide, mercuric chloride-inducedrenal dysfunction, pharmacological

probing, neonates (rats), 212

Acetylcholine

analogs of oxotremorine, receptor reserve(mice), 464

cholinergic neurotransmission, D 1 recep-

tor-linked mechanism, striatum(rats), 300

efflux, L-threo-3,4-dihydroxyphenylser-me, brain (guinea pigs), 621

endothelium-dependent relaxations, arti-ficial buffered solutions, aorta (rab-bits), 523

Acidosis, myocardial, effect of lidocaine,

coronary artery occlusion (dogs),1114

Acivicin, glutathione-derived thiols and

methylmercury, biliary and urinaryexcretion, inhibition of -y-glutamyl-transpeptidase (rats), 27

Action potentials, calcium-mediated slow,

bupivacaine and lidocaine, ventricu-

lar muscle (guinea pigs), 1001Acton, E. M., see Chuang, L. F., 372Adenosine

antagonism, atrioventricular conduction

time, alkyixanthines (guinea pigs),478

immunoglobulin E-dependent histaminesecretion, ad#{128}nosine inhibition, ba-sophil leukocytes, 1064

mediation of negative chronotropic ac-

tion, adenosine 5’ -triphosphate,sinus node (dogs), 791

Adenosine analog, caffeine and, psycho-

motor stimulant effects (monkeys),

179

Adenosine antagonists, Al- and A2-selec-

tive, cardiovascular effects (rats), 882

Adenosine triphosphate, mediation of ac-tion, adenosine, sinus node (dogs),

791

Adenylate cyclase

cardiac effects of xamoterol (guinea pigs),

1077

D2 dopamine receptors, tumor of anterior

pituitary gland (rats), 950

dopamine stimulated, responsiveness, re-

peated amphetamine pretreatment

(rats), 40Adrenalectomy, sympathoadrenal pressor

response, pheochromocytoma (rats),

637

Adrenoceptors

1160

atphaasymmetric catecholimidazolines, Ca-

techolamidines (rats), 121

clonidine hypotension and �3-endor-

phin, SHR rats, 378

control of calcium pump, norepineph-rine modulation (rats), 472

differential antagonism of pressor re-sponses, urotensin I (rats), 284

morphine-induced antinociception

(mice), 90alpha-i

agonism by SGD 101/75, anococcygeusmuscle (rats), 772

effects of norepinephrine, phosphati-

dylinositols (rats), 188norepinephrine regulation, phosphoi-

nositide hydrolysis (rats), 764

prostate, benign prostatic hypertrophy(humans), 326

receptor density regulation, brain(rats), 842

sympathoadrenal pressor response,

pheochromocytoma (rats), 637alpha-2

enhanced responsiveness, elevated pul-monary vascular tone (dogs), 158

fat cell characterization (dogs), 1041

alpha and beta, evaluation of ibopamine(rats), 455

betaagonist, metabolic regulation in lung

(sheep), 389

blocking activity, IC! 147,798 (cats,

dogs, rats, guinea pigs, toads), 818

cardiac effects, xamoterol (guinea pigs),

1077

effects of propranolol, reperfused myo-

cardium (dogs), 102fat cell characterization (dogs), 1041

beta-i, partial agonist activity (rats), 1025

beta-2control of venous circulation (dogs),

i 138

regulation by clenbuterol, autoradiog-raphy (rats), 707

Adriamycin, effect on DNA polymerase :ga,RNA polymerase II, leukemia cells(chickens), 372

AF-DX 1 16, selectivity of muscarinic antag-

onists, putative M1, M2 and M3 recep-tors (rats), 257

Agonistsbeta, clenbuterol and prenalterol, behav-

ior (rats), 588beta-2

metabolic regulation, fetal lung (sheep),

389

tracheal fluid flow, pulmonary mechan-ics (sheep), 394

muscarinic, analogs of oxotremorine, re-ceptor reserve (mice), 464

Aihara, H., see Araki, H., 686Airway

smooth muscle, influence of cartilage, ye-

rapamil effectiveness (guinea pigs),450

trachea, D-tubocurarine, contraction and

mediator release (guinea pigs), 558

Aiyar, N., Nambi, P., Stassen, F. L. andCrooke, S. T.: Effects of N-ethylmal-

eimide on arginine vasopressin-in-duced responses in an established

smooth muscle cell line, 217Alcohol, 2-butoxyethanol toxicity, meta-

bolic basis (rats), 222Alkylxanthines, atrioventricular conduction

time, antagonism of adenosine and

hypoxia (guinea pigs), 478

Allan, A. M., see Huidobro-Toro, J. P., 963

Altar, C. A., Boyar, W. C., Oei, B. and Wood,P. L.: Dopamine autoreceptors mod-ulate the in vivo release of dopaminein the frontal, cingulate and entor-hinal cortices, 115

Amastatin, aminopeptidase inhibition,angiotensins II and III, binding andmetabolism (rats), 957

Amiloride, mercuric chloride-induced renaldysfunction, pharmacological prob-ing, neonates (rats), 212

Amino acids, intestinal absorption of a-

methyldopa (rats), 443-y-Aminobutyric acid

benzodiazepine receptor antagonists,

CGS 9896 and ZK 91296, neurons inculture (mice), 48

receptor-chloride channel complex, anes-

thetic drugs, neurochemical actions(mice), 963

Aminopeptidase, inhibition with amastatinand bestatin, angiotensins II and III,binding and metabolism (rats), 957

Aminopyrine, Wy-45,727, characterization,H2-receptor antagonist (rats, dogs),607

Amiodarone, ventricular refractory period

prolongation, thyroid state (rats), 320Amphetamine

individual responses (rats), 917

repeated pretreatment, responsiveness,adenylate cyclase (rats), 40

Amrick, C. L., see Bennett, D. A., 595Amrinone, vascular relaxation (rats), 864Analgesia

kappa opioids (monkeys), 413mu opioid antagonist properties, cyclic

somatostatin octapeptide (mice), 1

receptor reserve, analogs of oxotremorine

(mice), 464Androgen, metabolism of 1-naphthol, en-

docrine regulation (rats), 344

Anesthetics, GABA receptor-chloride chan-

nel complex (mice), 963Angiotensins II and II, binding and metab-

olism, aminopeptidase inhibition,amastatin and bestatin (rats), 957

Ann, H. S., see Nagahama, S., 143Anorectics, reinforcing and subjective ef-

fects, normal human volunteers, 777

1987 Index 1161

Antagonistshistamine H2-receptor, effects of ORF

17583, gastric acid secretory state

(rats, dogs), 437

H2-receptor, gastric acid antisecretory

properties, Wy-45,727 (rats, dogs),

607

Antiarrhythmic agentsamiodarone, ventricular refractory period

prolongation, thyroid state (rats), 320711389-5, sodium channel block, giant ax-

ons (crayfish), 269Antidepressants

effects of clenbuterol and prenalterol, be-

havior, fixed-interval/fixed-ratioschedule (rats), 588

McN-5707, preclinical evaluation (rats),74

Antidotes, concurrent carbon monoxide/cy-

anide intoxication, methemoglobinforming cyanide antagonists (mice),70

Antigens, presentation, benzo(a)pyrene-in-

duced modulation (mice), 399Antimuscarinic agents, comparison, in vitro

actions, behavioral effects (rats), 796Antinociception, morphine-induced, de-

scending serotonergic and noradre-nergic pathways (mice), 90

Antitumor activity, metabolism of N-meth-ylformamide, deuterium isotope ef-

fect (mice), 3i2Anti-ulcer drugs, Wy-45,727, characteriza-

tion, H2-receptor antagonist (rats,dogs), 607

Anxiolytic, diazepam, home cage pretreat-ment (rats), 595

Aortaasymmetric catecholimidazolines and Ca-

techolamidines, alpha adrenoceptor(rats), 121

calcium utilization, phorbol dibutyrate,protein kinase C stimulation (rats),934

effects of norepinephrine, contraction andhydrolysis, aorta (rats), 188

palytoxin-induced contraction and re-

lease, prostaglandins, norepineph-rine (rats, rabbits), 1120

relaxing effects, 15-lipoxygenase prod-

ucts, arachidonic acid (rats), 945Arachidonic acid

calcium channel blockers, prostanoid gen-

eration, vasoconstriction (rabbits),646

exogenous free radical generating system,

injury to heart, eicosanoids (rats),673

pulmonary vasoconstriction (rabbits), 974

relaxing effects of 15-lipoxygenase prod-

ucts, aorta (rats), 945

Araki, H., Nojiri, M., Kimura, M. and Ai-hara, H.: Effect of minaprine on

layed neuronal death” in Mongolian

gerbils with occluded common ca-rotid arteries, 686

Ardell,J.L.,seeFee,J.D., 1006

Aronstam, R. S., see Carrier, G. 0., 531

Artery, tibial, inhibition of adrenergic neu-rotransmission, serotonin exposure(dogs), 493

Arthritis, endogenous morphine and co-deine, chemical characterization, reg-

ulation (rats), 583

Artymyshyn, R P., see Vos, P., 707

Ashizawa, N., see Yamada, S., 320Assays, radioligand binding, vasoactive pep-

tide receptor, submandibular gland(rats), 873

Autoimmunity, oxidative metabolites ofprocainamide, cytotoxicity, 833

Autoradiography, beta-2 adrenergic recep-tors, regulation by clenbuterol (rats),707

Axonal transport, reduced capacity of, no-codazole (frogs), 277

Axons, giant, sodium channel block, 711389-S (crayfish), 269

Axworthy, D. B., see Threadgill, M. D., 312

Baillie, T. A., see Threadgill, M. D., 312Baister, R. L., see Beardsley, P. M., 203

Barlow, J. J., see Kau, S. T., 818Barnett, J. V., Segal, D. S. and Kuczenski,

R.: Repeated amphetamine pretreat-ment alters the responsiveness ofstriatal dopamine-stimulated adenyl-ate cyclase to amphetamine-induceddesensitization, 40

Bass, A. S., Kohli, J. D., Lubbers, N. andGoldberg, L. I.: Mechanisms mediat-ing the positive inotropic and chron-otropic changes induced by dopex-amine in the anesthetized dog, 940

Basu, D. K. and Karmazyn, M.: Injury torat hearts produced by an exogenous

free radical generating system. Studyinto the role of arachidonic acid and

eicosanoids, 673

Battaglia, G., Yeh, S. Y., O’Hearn, E., Mol-liver, M. E., Kuhar, M. J. and DeSouza, E. B.: 3,4-Methylenedioxy-methamphetamine and 3,4-methyle-nedioxyamphetamine destroy sero-tonin terminals in rat brain: Quanti-

fication of neurodegeneration by

measurement of [3H]paroxetine-la-

beled serotonin uptake sites, 911

Beardsley, P. M. and Balster, R. L.: Behav-ioral dependence upon phencyclidine

and ketamine in the rat, 203

Behaviorcaffeine and adenosine analog, psycho-

motor stimulant effects (monkeys),

179

dependence, phencyclidine and ketamine(rats), 203

individual responses to amphetamine(rats), 917

Belardinelli, L., see Clemo, H. F., 478

Bennett, D. A. and Amrick, C. L.: Homecage pretreatment with diazepam: Ef-fects on subsequent conflict testingand rotorod assessment, 595

Ben-Nun, A., see Westarp, M. E., 614

Benyon, R. C., see Hughes, P. J., 1064Benzo(a)pyrene, induced modulation of an-

tigen presentation (mice), 399

Benzodiazepines, receptor antagonists, CGS9896 and ZK 91296, neurons in cul-ture (mice), 48

Benzphetamine, reinforcing and subjectiveeffects, normal human volunteers,

777

Benzylpenicillin, transport by choroidplexus (rats), 660

Bepridil, protective effects on calcium in-

jury, anoxic myocytes, heart ventric-ular muscle (rats), 1126

Berlan, M., see Taouis, M., 1041

Berson,G.,seeCruz,C., 1126

Bestatin, aminopeptidase inhibition, angio-tensins II and III, binding and metab-

olism (rats), 957

Bevan, J. A., see Laher, I., 566

Bevan, J. A., see Pearce, W. J., 812

Bick, P. H., see Myers, M. J., 399

Biliary excretion, inhibition of -y-glutamyl-transpeptidase, glutathione-derivedthiols, methylmercury (rats), 27

Biogenic amines, tetrahydropterin deriva-tives, entrance in brain, peripheraladministration (rats), 514

Bitterman, H., Phillips, G. R., III, Dragon,G. and Lefer, A. M.: Potentiation ofthe protective effects of a converting

enzyme inhibitor and a thromboxanesynthetase inhibitor in hemorrhagic

shock, 8

Blackall, D., see Owens, S. M., 96

Bleck, V., see Huidobro-Toro, J. P., 963Blood-brain barrier

darodipine and isradipine, binding to

plasma proteins, drug transfer (rats),

349

entrance of tetrahydropterin derivatives,peripheral administration (rats), 514

transport of benzylpenicillin, choroidplexus (rats), 660

Blood flowcerebral, diltiazem, autoregulation (dogs),

812

coronary, effects of propranolol (dogs),

102cyclosporine nephrotoxicity, alterations,

renal structure and function (rats),

749

epidermal growth factor-urogastrone,transforming growth factor-a, vas-

cular actions, 331ibopamine, vascular dopamine receptors

(dogs), 573Blood pressure, effects of serotonin receptor

agonists, antagonists (cats), 1152

Bolt, G. R., Itoh, H., Lederis, K. andMacCannell, K. L.: Differential an-tagonism of alpha-i and alpha-2 ad-

renoceptor-mediated pressor re-

sponses by urotensin I, a selectivemesenteric vasodilator peptide, 284

Borchardt, R. T., see Osiecka, I., 443

Bourassa, A., see Clemo, H. F., 478Boyar, W. C., see Altar, C. A., 115

Bozarth, J. M., see Chiu, A. T., 934Bradycardia, acute tolerance to opiates,

temporal factors (rabbits), 251

Bradykinin, heat-induced edema, contribu-tion of substance P (rats), 1071

Braindarodipine and isradipine, binding to

plasma proteins, drug transfer (rats),349

dopamine autoreceptors, release of dopa-mine (rats), 115

effects of L-threo-3,4-dihydroxyphenyl-serine, efflux, monoamines and ace-

tylcholine (guinea pigs), 621

entrance of tetrahydropterin derivatives,peripheral administration (rats), 514

naloxonazine effects, enkephalin analogs,

mu-i/mu/delta opioid binding (rats),

15neurochemical actions, anesthetic drugs,

GABA receptor-chloride channelcomplex (mice), 963

1162 Index Vol. 242

neurotoxic effects, 3,4-methylenedioxy-methamphetamine (rats), 911

nicotine binding sites, prenatal nicotineexposure (rats), 232

regulation, alpha- 1 adrenergic receptor

density (rats), 842Braughler, J. M., see Hall, E. D., 137Bremazocine, kappa agonist-induced di-

uresis (rats), 33Brodie, C. and Sampson, S. R.: Effects of

chronic ethanol treatment on mem-brane potential, its electrogenicpump component and Na-K pumpactivity of cultured rat skeletal myo-tubes, 1104

Brodie, C. and Sampson, S. R.: Effects ofethanol on electrophysiological prop-erties of rat skeletal myotubes in cul-

ture, 1098Bromobenzene, hepatic response, vitamin D

hormonal status (rats), 354Bronchi, leukotriene C4 characteristics and

binding (humans), 1019Brush border membrane, renal, substrates

for organic cation transporter, neu-

rotoxins (dogs), 152Buckley, S., see Warburton, D., 389, 394

Buckner, C. K., see Fishleder, R. I., 558Buckpitt, A. R., see Richieri, P. R., 485Bupivacaine, lidocaine and, calcium channel

blockade, ventricular muscle (guineapigs), 1001

Burka, L. T., see Ghanayem, B. I., 222Burks, T. F., see Shook, J. B., 1

2-Butoxyethanol, metabolic basis of toxic-ity, role ofalcohol, aldehyde dehydro-genases (rats), 222

Bylund, D. B., see Turner, J. T., 873

Caffeinecardiovascular effects (rats), 882psychomotor stimulant effects, adenosine

analog (monkeys), 179

Calcitonin gene-related peptide, effect ofcapssicin, smooth muscle, vas defer-ens (rats), 666

Calcium

antagonist, desmethoxyverapamil effects,

heart and vascular smooth muscle

(guinea pigs), 1090effects of N-ethylmalemide, arginine vas-

opressin-induced responses, smooth

muscle (rats), 217effects of norepinephrine, contraction and

hydrolysis, phosphatidylinositols(rats), 188

influence of cartilage, verapamil, airway

smooth muscle (guinea pigs), 450

injury, bepridil, heart ventricular muscle(rats), 1126

ionophore A23187

pulmonary vasoconstriction (rabbits),974

vasoconstriction, prostanoid generation(rabbits), 646

protein kinase C activation, myogenictone, TPA (rabbits), 566

vascular smooth muscle contraction,� phorbol dibutyrate, aorta (rats), 934

vitamin D hormonal status, hepatic re-sponse, bromobenzene (rats), 354

Calcium channelantagonists, prostanoid generation, vaso-

constriction in lungs (rabbits), 646

blockade, bupivacaine and lidocaine, yen-tricular muscle (guinea pigs), 1001

cerebrovascular serotonin receptors, cal-cium mechanisms (rats), 629

diltiazem and autoregulation, cerebralblood flow (dogs), 812

ryanocline, effects, skeletal muscle sarco-

plasmic reticulum (rabbits), 56Calcium pump, norepinephrine modulation

(rats), 472

Campbell, K. S. and Munson, A. E.: Poten-tiation of the in vitro T-dependent

antibody response by the B subunit

of cholera toxin, 895Capsaicin, effect on smooth muscles, vas

deferens, calcitonin gene-related pep-

tide (rats), 666

Carbachol, induced inositide tUrnover, c#{233}r-ebellar granule cells, 238

fl-Carbolines, benzodiazepine receptor an-

tagonists, CGS 9896 and ZK 91296,

neurons in culture (mice), 48

Carbon monoxide, antidotal use, methemo-globin forming cyanide antagonists,cyanide intoxication (mice), 70

Cardinal, R., see Lambert, C., 320

Cardinale, G., see Donnerer, J., 583Cardiovascular system

Al- and A2-selective adenosine antago-nists (rats), 882

acute tolerance to opiates, temporal fac-tors (rabbits), 251

effects of LY171555, role of vasopressin

(rats), 143

evaluation of ibopamine, alpha and betaadrenoceptor mediation (rats), 455

myocardial and systemic hemodynamicresponses, leukotriene D4, LY171883

(monkeys), 62Carrier, G. 0. and Aronstam, R. S.: Altered

muscarinic receptor properties and

function in the heart in diabetes, 531Carroll, M. E.: A quantitative assessment of

phencyclidine dependence producedby oral self-administration in rhesus

monkeys, 405Cartilage, influence on effectiveness of ye-

rapamil, airway smooth muscle(guinea pigs), 450

Cations, organic, transport across renalbrush border membrane vesicles,neurotoxin substrates (dogs), 152

Caudate putamen, dopamine autoreceptors(rats), 115

Cavero, I., see Hicks, P. E., 1025Central nervous system

Dl and D2 dopamine agonists, discrimi-native stimulus properties (rats), 804

effects of corticotropin-releasing factor,ventral tegmental area (rats), 757

substance P receptor antagonist, in-trathecal administration, hemody-namics (rats), 131

Cerebellar granule cells, carbachol-inducedinositide turnover, 238

Cerebellum, blood flow, diltiazem, autoreg-ulation (dogs), 812

Cerebral cortex, alpha-i adrenergic receptor

density regulation (rats), 842Cerebrospinal fluid

clonidine hypotension and fl-endorphin,

alpha adrenergic and opiate blockers,SHR rats, 378

transport of benzylpenicillin, choroidplexus (rats), 660

CGS-16617, thromboxane synthetase inhib-itor and, protecting effects, hemor-rhagic shock (rats), 8

CGS i5855A, dopamine autoreceptors, neo-cortex (rats), 115

CGS 15943A, pharmacological characteri-

zation (guinea pigs), 784

Chait, L. D., Uhlenhuth, E. H. and Johan-

son, C. E.: Reinforcing and subjectiveeffects of several anorectics in nor-

mal human volunteers, 777Chaki, K., see Sato, T., 654

Chang, J.-Y. and Owman, C.: Involvementof specific receptors and calciummechanisms in serotonergic con-

tractile response of isolated cerebralandperipheral arteries from rats, 629

Chase, R. L., see Hall, E. D., 137

Chaumet-Riffaud, P., see Urien, S., 349Chen, I.-W., see Lin, J. H., 1013

Chen, Y.-F., see Nagahama, S., 143Chiang, P. K., see Witkin, J. M., 796Chiu, A. T., Bozarth, J. M., Forsythe, M. S.

and Timmermans, P. B. M. W. M.:Ca� utilization in the constriction of

rat aorta to stimulation of protein

kinase C by phorbol dibutyrate, 934Chloride

GABA receptor-chloride channel com-plex, anesthetic drugs, neurochemicalactions (mice), 963

secretion in colon, cholinergic receptors(guinea pigs), 600

S-(2-Chloroethyl)glutathione, nephrotoxic-ity (rats), 741

Chlorothiazide, mercuric chloride-inducedrenal dysfunction, pharmacological

probing, neonates (rats), 212

Choca, J. I., Proudfit, H. K. and Green, R.D.: Identification of alpha-i and al-pha-2 adenosine receptors in the ratspinal cord, 905

Choi, D. W., Peters, S. and Viseskul, V.:Dextrorphan and levorphanol selec-

tively block N-methyl-D-aspartatereceptor-mediated neurotoxicity oncortical neurons, 713

Cholera toxin, B subunit, T-dependent anti-body response (mice), 895

Choroid plexus

efficacies of piperazines, serotonergic re-ceptors, 552

transport of benzylpenicillin (rats), 660

Chronotropism, altered muscarinic receptorproperties, heart and diabetes (rats),

531Chuang, D.-M., see Xu, J., 238Chuang, L. F., Chuang, R. Y., Acton, E. M.,

Israel, M. and Yu, M.: Effect of mor-pholinyladriamycin analogs and adri-amycin on the activities of DNA po-lymerase a and RNA polymerase II

of chicken leukemia cells, 372Chuang, R. Y., see Chuang, L. F., 372Church, M. K., see Hughes, P. J., 1064CI-914, vascular relaxation (rats), 864CI-930, vascular relaxation (rats), 864Cicloprolol, beta-i partial agonist activity

(rats), 1025

Cigarette smoking, lung metabolism of nic-

otine, prostaglandin H synthase,mixed-function oxidase (rabbits, hu-

mans), 827Cimetidine, Wy-45,727, characterization,

1987 Index 1163

H2-receptor antagonist (rats, dogs),607

Circulation

splanchnic, a�pha adrenoceptors, uroten-sin I (rats), 284

venous, beta-2 adrenoceptor control

(dogs), 1138Cit.alopram, selective labeling of serotonin

uptake, brain, imipramine labeling(rats), 364

Civelli, M., Oliva, D., Mezzetti, M. and Ni-cosia, S.: Characteristics and distri-bution of specific binding sites forleukotriene C4 in human bronchi,1019

Clancy, B. M., Osman, R. and Maayani, S.:

Kinetics of competitive drug action

at 5-hydroxytryptamine2 receptors inisolated rabbit aorta, 108

Clara cells, efflux of naphthalene oxide, re-active naphthalene metabolites, hep-atocytes (mice), 485

Clemo, H. F., Bourassa, A., Linden, J. andBelardinelli, L.: Antagonism of theeffects of adenosine and hypoxia on

atrioventricular conduction time by

two novel alkylxanthines: Correla-tion with binding to adenosine A1receptors, 478

Clenbuterolprenalterol and, behavior, fixed-interval/

fixed-ratio schedule (rats), 588regulation of beta-2 adrenergic receptors,

autoradiography (rats), 707Clonidine, hypotension, relationship to

brain fl-endorphin, SHR rats, 378Cocaine

induced hepatotoxicity, antagonism,

phentolamine and yohimbine (mice),726

methamphetamine-induced neurochemi-

cal changes (rats), 507Codeine, endogenous morphine and, chem-

ical characterization, regulation

(rats),583Coffey, J., see Donnerer, J., 583

Cohen, I. R., see Westarp, M. E., 614

Cohen, L., Vereault, D., Wasserstrom, J. A.,

Retzinger, G. S. and Kezdy, F. J.:Evidence that uncharged verapamilinhibits myocardial contractility, 721

Cohen, M. L., see Kauffman, R. F., 864

Cohen, R. A.: Inhibition of adrenergic neu-

rotransmission in canine tibial artery

after exposure to 5-hydroxytrypt-amine in vitro, 493

Collen, D., see Stump, D. C., 245

Colon, mediation of secretion, cholinergicreceptors (guinea pigs), 600

Complements, effects of L-652,731, pulmo-nary hypertension (sheep), 1035

Conn, P. J. and Sanders-Bush, E.: Relativeefficacies of piperazines at the phos-phoinositide hydrolysis-linked sero-tonergic (5-HT-2 and 5-Ht-lc) recep-tors, 552

Consolo, S., Wu, C. F. and Fusi, R.:D-ireceptor-linked mechanism modu-lates cholinergic neurotransmissionin rat striatum, 300

Contractility, myocardial, mediation, un-charged verapamil, 721

Cooke, H. J., see Kuwahara, A., 600

Corey, E. J., see Uotila, P., 945

Coronary artery, occlusion, myocardial ad-dosis, effect of lidocaine (dogs), 1114

Cortese, M., see Osiecka, I., 443Corticotropin-releasing factor, .effects in

ventral tegmental area (rats), 757Cosico, L., see Warburton, D., 389, 394Costa, E., see Eva, C., 888Cote, D. T., see Ghai, G., 784Cotinine, lung metabolism of nicotine, pros-

taglandin H synthase, mixed-func-tion oxidase (rabbits, humans), 827

Coulombe, P. A., see Haddad, P., 354Cowan, A., see Murray, C. W., 500Coyle, D. E. and Sperelakis, N.: Bupivacaine

and lidocaine blockade of calcium-mediated slow action potentials inguinea pig ventricular muscle, 1001

Crews, F. T., see Gonzales, R A., 764

Crooke, S. T., see Aiyar, N., 217

Crowe, V. G., see Kauffman, R. F., 864

Cruciani, R. A., Lutz, R. A., Munson, P. J.and Rodbard, D.: Naloxonazine ef-fects on the interaction of enkephalinanalogs with mu-i, mu and deltaopioid binding sites in rat brain mem-branes, 15

Cruz, C., Zaoui, A., Berson, G. and Younes,A.: Protective effects of bepzidil oncalcium injury of anoxic myocytes

isolated from adult rat heart ventric-ular muscle, 1126

Cunard, C. M., see Uotila, P., 945Curtius, H.-C., see Levine, R. A., 514

CV-6209, antagonist, platelet activating fac-tsr (humans, rabbits), 263

Cyanide, intoxication, antidotal use, met-hemoglobin forming antagonists(mice), 70

Cyclic AMP, new inotropic agents, vascularrelaxation (rats), 864

Cyclic GMP, new inotropic agents, vascularrelaxation (rats), 864

Cyclosporine, nephrotoxicity, alterations,renal structure and function (rats),749

Cyproheptadine, calcium mechanisms, cer-ebrovascular serotonin receptors(rats), 629

Cytochrome P-450, vitamin D hormonalstatus, hepatic response, bromoben-zene (rats), 354

Cytotoxicity, oxidative metabolites of pro-cainamide, 833

d’Alarcao, M., see Uotila, P., 945Dalton, T. K., see Mullin, M. J., 541

Daly, J. W., see Evoniuk, G., 882D’Amato, R. J., Largent, B. L., Snowman,

A. M. and Snyder, S. H.: Selectivelabeling of serotonin uptake sites inrat brain by [3HJcit.alopram con-trasted to labeling of multiple sitesby [3HJimipramine, 364

Darodipine, isradipine and, binding toplasma proteins, blood-brain barrier(rats), 349

Davenport, P. A., see Vos, P., 707

Davidesko, D., see Doods, H. N., 257Davis, B. B., see Matt.amal, M. B., 827

De Cock, F., see Stump, D. C., 245

De Deyn, P. P.� and Macdonald, R. L.: CGS9896 anti ZK 91296, but not CGS8216 and RO 15-1788, are pure ben-zodiazepine receptor antatonists onmouse neurons in culture, 48

Degott, C., see Geneve, J., 1133

de Jonge, A., see Doods, H. N., 257

DeLanney, L. E., see Finnegan, K. T., 1144Dependence

kappa opioids (monkeys), 413, 428phencyclidine, assessment, oral self-ad-

ministration (monkeys), 405Derynck, R., see Gan, B. S., 331Desmethoxyverapamil, effects on heart and

vascular smooth muscle (guineapigs), 1090

De Souza, E. B., see Battsglia, G., 911Deuterium, isotope effect, metabolism of N-

methylformamide (mice), 312Dextrorphan, levorphanol and, NMDA neu-

rotoxicity, cortical neurons, 713

Diabetes, altered muscarinic receptor prop-erties (rats), 531

Diazepam, home cage pretreatment, conflicttesting, rotorod assessment (rats),595

Dicyclomine, selectivity of muscarinic an-tagonists, putative M1, M2 and M3(rats), 257

Diet, composition of, effect ofdrug response,

phenobarbital (rats), 16�Diflunisal, ester and ether glucuronidation,

effects of phenobarbital (rats), 1013Digitonin, kinetic properties of pirenzepine

binding, muscarinic receptors, fore-brain and heart (rats), 981

L-threo-3,4-Dihydroxyphenylserine, effects

on efflux, monoamines and acetyl-

choline, brain (guinea pigs), 621Diltiazem

autoregulation and, cerebral blood flow(dogs), 812

calcium antagonists, prostanoids (rab-bits), 646

calcium mechanisms, cerebrovascular se-rotonin receptors (rats), 629

lysosomal enzymes, redistribuiton inhibi-tion, ischemic heart (rats), 1109

4-Diphenylacetoxy-N-methylpiperidine

methobromide, selectivity of musca-rinic antagonists, putative M1, M2and M3 receptors (rats), 257

i,3-Dipropyl-8-phenylxanthine amine con-

gener, cardiovscular effects (rats),882

Discriminationmorphine/saline/naltrexone, morphine

treatment (pigeons), 195stimulus properties, Dl and D2 dopamine

agonists (rats), 804Diuresis

effect of pinacidil (dogs), 1050kappa agonist-induced (rats), 33

kappa opioids (monkeys), 413Diuretics

IC! 147,798 (cats, dogs, rats, guinea pigs,

toads), 818

induced growth failure, reversal by so-dium depletion (rats), 85

DNA polymerase a, RNA polymerase IIand, effect of morpholinyladriamycinanalogs, adriamycin (chickens), 372

Domalik-Wawrzynski, L., see O’Keefe, R.J., 699

Domperidonedopaminergic modulation, rectosigmoid

motility (humans), 548role of vasopressin, cardiovascular effects

of LY171555 (rats), 143

Donnerer, J., Cardinale, G., Coffey, J.,

1164 Index Vol. 242

Lisek, C. A., Jardine, I. and Spector,S.: Chemical characterization and

regulation of endogenous morphineand codeine in the rat, 583

Doods, H. N., Mathy, M.-J., Davidesko, D.,van Charldorp, K. J., de Jonge, A.and van Zwieten, P. A.: Selectivity ofmuscarinic antagonists in radiolig-and and in vivo experiments for theputative M1, M2 and M3 receptors,

257Dopamine

autoreceptors, release of dopamine, neo-cortex (rats), 115

cocaine effects, methamphetamine-in-duced neurochemical changes (rats),507

corticotropin-releasing factor effects, yen-

tral tegmental area (rats), 757Dl and D2 agonists, discriminative stim-

ulus properties (rats), 804depletion in striatum, 1,2,3,6-tetrahydro-

1-methyl-4-(methylpyrrol-2-

yl)pyridine (mice), 1144

ibopamine anda�pha and beta adrenoceptor mediation

(rats), 455vascular dopamine receptors (dogs),

573

modulation of rectosigmoid motility, ac-tion of domperidone (humans), 548

Dopexamine, cardiac effects (dogs), 940Dotson, R. A., see Ghai, G., 784Dragon, G., see Bitterman, H., 8

Duffy, P., see Kalivas, P. W., 757

Duggan, D. E., see Lin, J. H., 1013

Duman, R. S., see Zorn, S. H., 173du Souich, P., see Marleau, S., 338Dykstra, L. A., Gmerek, D. E., Winger, G.

and Woods, J. H.: Kappa opioids in

rhesus monkeys. I. Diuresis, seds-tion, analgesia and discriminativestimulus effects, 413

Dykstra, L. A., Gmerek, D. E., Winger, G.and Woods, J. H.: Kappa opioids in

rhesus monkeys. II. Analysis of theantagonistic actions of quadazocineand fl-funal trexamine, 421

Dykstra, L. A., see Gmerek, D. E., 428

Edema, heat-induced, contribution of sub-stance P (rats), 1071

Eicosanoids, exogenous free radical gener-ating system, injury to heart, arachi-donic acid (rats), 673

Enantiomers, alpha adrenoceptor, affinityand efficacy relationships, aorta(rats), 121

Encephalomyelitis, experimental allergic,pharmacological model, T cells (rats),614

�-Endorphin

polymorphonuclear leukocyte superoxideproduction, stereoselective opiate re-ceptor (humans), 579

relationship to clonidine hypotension,SHR rats, 378

Endothelium-derived relaxing factor, artifi-cial buffered solutions, aorta (rab-bits), 523

Enkephalin analogs, naloxonazine effects,mu-i/mu/delta opioid binding, brainmembranes, 15

Enna,S.J.,seeZorn,S.H., 173Enoximone, vascular relaxation (rats), 864

Enzymes, enkephalin-degrading, D-Arg�-

substituted tetrapeptides (mice), 654Epidermal growth factor-urogastrone,

transforming growth factor-a and,vascular actions, 331

Epinephrineasymmetric catecholimidazolines and ca-

techolamidines, alpha adrenoceptor,aorta (rats), 121

sympathoadrenal pressor response (rats),

637Epinine

ibopamine andalpha and beta adrenoceptor mediation

(rats), 455vascular dopmaine receptors (dogs),

5737-Epitaxol, conversion from taxol, cell cul-

ture medium, 692Erickson, R. R., Prasad, J. S. and Holtzman,

J. L.: The role of NADPH- and re-duced glutathione-dependent en-zymes in the norepinephrine modu-lation ofthe ATP-dependent, hepatic

microsomal calcium pump: A newpathway for the noradrenergic regu-lation ofcytosolic calcium in the hep-atocyte, 472

Ernst, C., see Seeger, W., 646Erythrocytes, T-dependent antibody re-

sponse, B subunit of cholera toxin(mice), 895

Estrogens, metabolism of 1-naphthol, en-

docrine regulation (rats), 344

Ethanolactions on voltage-sensitive sodium chan-

nels (rats), 531, 536antilesion properties of rioprostil (rats,

dogs), 917effects on electrophysiological properties,

skeletal myotubes (rats), 1098effects on membrane potential, sodium-

potassium pump activity, skeletalmyotubes (rats), 1104

pharmacodynamics, effects of acute star-vation, refeeding and diet composi-tion (rats), 166

Ethylene glycol monobutyl ether, metabolicbasis of toxicity, role of alcohol, al-dehyde dehydrogenases (rats), 222

Ethylketazocine, kappa agonist-induced di-uresis (rats), 33

N-Ethylmaleimide, effects on arginine vas-opressin-induced responses, estab-lished smooth muscle cell line (rats),217

Etizolam, CV-6209, antagonist of plateletactivating factor (humans, rabbits),263

Eva, C. and Costa, E.: In rat hippocampus,

somatostatin 14 and muscarinic re-ceptor ligands modulate an adenylatecyclase belonging to a common do-main of the receptor, 888

Evoniuk, G., Jacobson, K. A., Shamim, M.T., Daly, J. W. and Wurtman, R. J.:Al- and A2-selective adenosine an-tagonist: In vivo characterization ofcardiovascular effects, 882

Farmer, P. B., see Threadgill, M. D., 312

Farmer, S. G., see Rseburn, D., 450

Farrow, K. C., see Threadgill, M. D., 312Fat cells, beta and alpha-2 adrenoceptors

(dogs), 1041

Fatty acids, mitochondrial $-oxidation, pir-profen (mice), 1133

Fedan, J. S., see Raeburn, D., 450Fee, J. D., Randall, W. C., Wurster, R. D.

and Ardell, J. L.: Selective ganglionic

blockade of vagal inputs to sinoatrialand/or atrioventricular regions, 1006

Fenoldopam, ibopamine and, vascular do-pamine receptors (dogs), 573

Fentanyl, effects on vasopressin secretion

(humans), 970Fibrinolysis, urokinase-type plasminogen

activator, single chain forms, phar-macokinetics (humans), 245

Fine, B. P., Ty, A., Lestrange, N., Maher,E. and Levine, 0. R.: Diuretic-in-duced growth failure in rats and itsreversal by sodium repletion, 85

Finnegan, K. T., Irwin, I., DeLanney, L. E.,Ricaurte, G. A. and Langston, J. W.:1,2,3,6-Tetrahydro-1-methyl-4-

(methylpyrrol-2-Y1)pyridine: Stud-ies on the mechanism of action ofMPTP, 1144

Fisher, D. M., see Weiskopf, R. B., 970Fishleder, R. I., Ro, J., Graziano, F. M., Will,

J. A. and Buckner, C. K.: An exami-nation of the ability of d-tubocura-rine to evoke contraction and media-tor release from superfused tracheaand parenchymal strips isolated fromthe guinea pig, 5, 58

Fix, J. A., see Osiecka, I., 443Forebrain

kinetic properties of pirenzepine binding,

muscarinic receptors, digitonin(rats), 981

thermodynamics of pirenzepin binding,muscarinic receptors (rats), 991

Forsythe, M. S., see Chiu, A. T., 934Foureman, G., see Kramer, R. A., 741France, C. P. and Woods, J. H.: Morphine,

saline and naltrexone discriminationin morphine-treated pigeons, 195

Francis, J. E., see Ghai, G., 784

Fra.zer, A., see Vos, P., 707

Free radicals, injury to heart, arachidonicacid, eicosanoids (rats), 673

Freneaux,E.,seeGeneve,J., 1133

Fujii, Y., see Nishino, N., 621

Fujiwara, H., see Nishino, N., 621Fujiwara, M., see Inoue, M., 1086Fujiwara, M., see Muramatsu, I., 269

Fujiwara, M., see Narumiya, S., 306Fukushima, M., see Narumiya, S., 306�3-Funaltrexamine, antagonistic actions,

kappa opioids (monkeys), 421Furosemide

induced growth failure, reversal, sodiumrepletion (rats), 85

mercuric chloride-induced renal dysfunc-tion, pharmacological probing, neo-nates (rats), 212

Furuta, S., see Sato, T., 654

Fusi, R., see Consolo, S., 300

Galzin, A.-M., see Passarelli, F., 1056Gan, B. S., Hollenberg, M. D., MacCannell,

K. L., Lederis, K., Winkler, M. E.and Derynck, R.: Distinct vascularactions of epidermal growth factor-urogastrone and transforming growth

factor-a, 331Ganglia, sinoatrial and atrioventricular, se-

lective blockade (dogs), 1006

1987 Index 1165

Gardner, C. R., see Osiecka, I., 443Gardocki, J. F., see Shank, R. P., 74

Gari#{233}py,L., see Marleau, S., 338

Gascon-Barr#{233},M., see Haddad, P., 354Gastric acid

antilesion properties of rioprostil (rats,dogs), 917

antisecretory properties of Wy-45,727,characterization, H2-receptor antag-onist (rats, dogs), 607

effects of ORF 17583 (rats, dogs), 437Gastrointestinal tract, mu opioid antagonist

properties, cyclic somatostatin octa-peptide (mice), 1

Gay, R. G., see Lee, R. W., 1138Gekker, G., see Sharp, B. M., 579

Geneve, J., Labbe, G., Degott, C., Letteron,P., Freneaux, E., Larrey, D., Hayat-Bonan, B. and Pessayre, D.: Inhibi-tion of mitochondrial fl-oxidation offatty acids by pirprofen. Role in mi-

crovesicular steatosis due to this non-steroidal anti-inflammatory drug,

1133

Gescher, A., see Threadgill, M. D., 312Ghai, G., Francis, J. E., Williams, M., Dot-

son, R. A., Hopkins, M. F., Cote, D.T., Goodman, F. R. and Zimmerman,

M. B.: Pharmacological characteri-zation of CGS 15943A: A novel nonx-anthine adenosine antagonist, 784

Ghanayem, B. I., Burka, L. T. and Mat-thews, H. B.: Metabolic basis of

ethylene glycol monobutyl ether (2-butoxyethanol) toxicity: Role of al-cohol and aldehyde dehydrogenases,222

Giachetti, A., see Zorn, S. H., 173Gibb, J. W., see Hanson, G. R., 507Giles, R. E., see Kau, S. T., 818Ginkgolide B, CV-6209, antagonist of plate-

let activating factor (humans, rab-bits), 263

Giraldo, E., see Zorn, S. H., 173Glucuronidation, ester and ether, diflunisal,

effects of phenobarbital (rats), 1013Glutamate, dextrorphan and levorphanol,

NMDA neurotoxicity, cortical neu-rons, 713

‘y-Glutamyltranspeptidaseeffect of inhibition, biliary and urinary

excretion, glutathione-derived thiolsand methylmercury (rats), 27

uptake by kidney, nephrotoxicity, S-(2-chloroethyl)glutathione (rats), 741

Glutathione

cocaine-induced hepatotoxicity, antago-nism, phentolamine and yohimbine(mice), 726

control of calcium pump, norepinephrinemodulation (rats), 472

efflux of naphthalene oxide, reactive na-phthalene metabolites, hepatocytes

(mice), 485renal transport, nephrotoxicity, S-(2-

chloroethyl)glutsthione (rats), 741

thiols and methylmercury, biliary and un-nary excretion, inhibition of -y-glu-

tsmyltranspeptidase (rats), 27Glycogen, beta-2 agonist, metabolic regula-

tion, fetal lung (sheep), 389Gmerek, D. E., Dykstra, L. A. and Woods,

J. H.: Kappa opioids in rhesus mon-keys. III. Dependence associated withchronic administration, 428

Gmerek, D. E., see Dykstra, L. A., 413, 421Goldberg, L. I., see Bass, A. S., 940

Goldberg, L. I., see Kamien, J. B., 804Goldberg, M. E., see Kau, S. T., 818Goldberg, S. R., see Katz, J. L., 179Goldman, S., see Lee, H. W., 1138

Gonzales, R. A., Crews, F. T., Sumners, C.and Raizada, M. K.: Norepinephrine

regulation of alpha-l receptors andalpha-i-stimulated phosphoionsitidehydrolysis in primary neuronal cul-tures, 764

Goodman, F. R., see Ghai, G., 784Gordon, R. K., see Witkin, J. M., 796Goto, K., see Saito, A., 666Graham, D. L. and Skett, P.: Endocrine

regulation of the metabolism of 1-naphthol in the rat, 344

Gray, J. A. and Kavlock, R. J.: Pharmaco-

logic probing of mercuric chloride-induced renal dysfunction in the neo-natal rat, 212

Graziano, F. M., see Fishleder, R. I., 558

Green, R. D., see Choca, J. I., 905Greene, K. E., see Kramer, R. A., 741Gregus, Z., Stein, A. F. and Klaassen, C. D.:

Effect of inhibition of -y-glutamyl-transpeptidase on biliary and urinaryexcretion of glutathione-derivedthiols and methylmercury, 27

GTPase, effects of N-ethylmaleimide, argi-nine vasopressin-induced responses,

smooth muscle (rats), 217

Guerrero, J. L., see O’Keefe, R. J., 699

Haddad, P., Coulombe, P. A. and Gascon-

Barr#{233},M.: Influence of the vitamin

D hormonal status on the hepatic

response to bromobenzene, 354

Hahn, R. A. and MacDonald, B. R.: Primatemyocardial and systemic hemody-namic responses to leukotriene D4:

Antagonism by LY171883, 62

Hall, E. D., McCall, J. M., Chase, R. L.,

Yonkers, P. A. and Braughler, J. M.:A nonglucocorticoid steroid analog ofmethylprednisolone duplicates its

high-dose pharmacology in models of

central nervous system trauma andneuronal membrane damage, 137

Halothane, hepatitis, liver microsomal poly-

peptide antigens (rabbits), 733Hamada, A., see Rice, P. J., 121

Hanano, M., see Suzuki, H., 660Haneda, T., see Ichihara, K., 1109Hanson, G. R., Matsuda, L. A. and Gibb, J.

W.: Effects of cocaine on metham-phetamine-induced neurochemical

changes: Characterization of cocaineas a monoamine uptake blocker, 507

Harbison, R. D., see James, R. C., 726Harding, J. W., see Abhold, R. H., 957Hardwick, W. C., see Owens, S. M., 96Harris, L. T., see McCall, R. B., 1152Harris, R. A., see Huidobro-Toro, J. P., 963Harris, R. A., see Mullin, M. J., 541Hart, J. C., see Leander, J. D., 33Hashimoto, K., see Tsujimoto, G., 637Hattori, Y., Sakuma, I., Nakao, Y. and

Kanno, M.: Pharmacological analysisof the cardiac actions of xamoterol, abeta adrenoceptor antagonist withpartial agonistic activity, in guineapig heart: Evidence for involvement

ofadenylate cyclase system in its car-diac stimulant actions, 1077

Hay, D. W. P., see Raeburn, D., 450Hayashi, E., see Yamada, S., 320Hayashi, S. and Hester, R. K.: Endothe-

hum-dependent relaxations in rabbit

aorta are depressed in artificial buff-ered solutions, 523

Hayat-Bonan, B., see Geneve, J., 1133

Head, neuronal membrane damage, nonglu-

cocorticoid steroid analog of methyl-prednisolone (mice), 137

Heartaltered muscarinic receptor properties

(rats), 531desmethoxyverapamil effects (guinea

pigs), 1090dopexamine effects (dogs), 940injury, exogenous free radicals, arachi-

donic acid and eicosanoids (rats), 673

ischemic

extraneuronal uptake, isoproterenol

(rats), 1086lysosomal enzymes, diltiazem (rats),

1109kinetic properties of pirenzepine binding,

muscarinic receptors, digitonin

(rats), 981

negative chronotropic action in the sinus

node, mediation, adenosine (dogs),791

selective blockade, sinoatrial and atrio-

ventricular regions (dogs), 1006thermodynamics of pirenzepine binding,

muscarinic receptors (rats), 981ventricular muscle, calcium injury, bepri-

dil (rats), 1126

xamoterol effects (guinea pigs), 1077Heart rate, effects of serotonin receptor ag-

onists, antagonists (cats), 1152Heat, induced edema, contribution of sub-

stance P (rats), 1071Heikkila, R. E., see Kindt, M. V., 858Heikkila, R. E., see Sonsalla, P. K., 850Helke, C. J., Phillips, E. T. and O’Neill, J.

T.: Intrathecal administration of asubstance P receptor antagonist:Studies on peripheral and centralnervous system hemodynamics andon specificity of action, 131

Hepatitis, halothane-associated, liver mi-

crosomal polypeptide antigens (rab-bits), 733

Hepatocytescontrol of calcium pump, norepinephrine

modulation (rats), 472efflux of naphthalene oxide, reactive na-

phthalene metabolites (mice), 485Hepatotoxicity

cocaine-induced, antagonism, phentola-mine and yohimbine (mice), 726

metabolism of N-methylformamide, deu-terium isotope effect (mice), 312

HEPES, endothelium-dependent relaxa-tions, aorta (rabbits), 523

Hester, R. K., see Hayashi, S., 523

Hicks, P. E., Cavero, I., Manoury, P., Le-fevre-Borg, F. and Langer, S. Z.:Comparative analysis of beta- 1 adre-noceptor agonist and antagonist po-

tency and selectivity of cicloprolol,xamoterol and pindolol, 1025

Hifumi, K., see Inoue, M., 1086Hippocampus

1166 Index Vol. 242

effect of minaprine, delayed neuronaldeath (gerbils), 686

somatostatin 14 and muscarinic receptorligands, adenylate cyclase modula-tion (rats), 888

Histamine

H2-receptor antagonists, effects of ORF17583, gastric acid secretory state

(rats, dogs), 437immunoglobulin E-dependent secretion,

adenosine inhibition, basophil leu-kocytes, 1064

D-tubocurarine, contraction and mediatorrelease, trachea and parenchymalstrips (guinea pigs), 558

Hoffman, B. B., see Tsujimoto, G., 637Hollenberg, M. D., see Gan, B. S., 331Holmes, M. A., see Weiskopf, R. B., 970Holohan, P. D., see Sokol, P. P., 152Holtzman, J. L., see Erickson, R. R., 472Honda, K., see Yamads, S., 320

Hopkins, M. F., see Ghai, G., 784Horwitz, S. B., see Ringel, I., 692

Hovav, E. and Weinstock, M.: Temporalfactors influencing the developmentof acute tolerance to opiates, 251

Howe, B. B., see Kau, S. T., 818

Hruby, V. J., see Shook, J. E., 1Hsu, C.-H., see Jackson, N. M., 749Hughes, P. J., Benyon, R. C. and Church,

M. K.: Adenosine inhibits immuno-globulin E-dependent histamine se-cretion from human basophil leuko-cytes by two independent mecha-nisms, 1064

Huidobro-Toro, J. P., Bleck, V., Allan, A.M. and Harris, R. A.: Neurochemicalactions of anesthetic drugs on the y-aminobutyric acic receptor-chloridechannel complex, 963

Hume, A. S., see Moore, S. J., 70Humes, H. D., see Jackson, N. M., 749Hunt, W. A., see Mullin, M. J., 536, 54115-Hydroperoxyeicosatetraenoic acid, 15-li-

poxygenase products, relaxing ef-fects, aorta (rats), 945

N-2-Hydroxyethylpiperazine-N’-2-ethane-

sulfonic acid, see HEPES5-Hydroxytryptsmine, see Serotonin

Hypercapnia, hypoxemia and/or, lidocaineand indocyanine green kinetics (nab-bits), 338

Hypercarbia, effects of fentanyl, vasopres-sin secretion (humans), 970

Hypertension, pulmonary, effects of L-652,731 (sheep), 1035

Hypothalamus, potassium and electricalstimulation, serotonin release (rats),1056

Hypothermia, analogs of oxotremorine, re-ceptor reserve (mice), 464

Hypoxemia, hypercapnia and/or, lidocaine

and indocyanine green kinetics (rab-bits), 338

Hypoxia, antagonism, atnioventricular con-duction time, alkylxanthines (guineapigs), 478

Ibopamineevaluation, a�pha and beta adrenoceptor

mediation (rats), 455vascular dopamine receptors (dogs), 573

Ichihara, K., Haneda, T., Onodera, S. andAbiko, Y.: Inhibition of ischemia-in-

duced subcellular redistribution of ly-

sosomal enzymes in the perfused ratheart by the calcium entry blocker,diltiazem, 1109

IC! 147,798, beta adrenoceptor blocking ac-tivity (cats, dogs, rats, guinea pigs,toads), 818

Iga, T., see Suzuki, H., 660Imipramine, selective labeling of serotonin

uptake, citalopram labeling, brain(rats), 364

Immunoblotting, halothane-associated hep-

atitis, liver microsomal polypeptideantigens (rabbits), 733

Immunoglobulin E, histamine secretion,adenosine inhibition, basophil leu-

kocytes, 1064Immunoglobulin M, T-dependent antibody

response, B subunit of cholera toxin(mice), 895

Immunomodulation, benzo(a)pyrene, anti-

gen presentation (mice), 399Immunosuppressive agents, pharmacologi-

cal model, experimental allergic en-cephalomyelitis, T cell-mediated(rats), 614

Imura, Y., see Terashita, Z.-I., 263

Indocyanine green, lidocaine and, kinetics,hypoxemia and/or hypercapnia (rab-bits), 338

Ingenito, A. J., see Mastrianni, J. A., 378Inoki, R., see Yonehara, N., 1071Inositol hydrolysis, alpha-i receptors, nor-

epinephrine regulation (rats), 764Inositol phosphate, effects of N-ethylmal-

eimide, arginine vasopressin-induced

responses, smooth muscle (rats), 217Inotropic agents

evaluation of ibopamine, alpha and betaadnenoceptor mediation (rats), 455

vascular relaxation (rats), 864Inoue, M., Hifumi, K., Kurahashi, K. and

Fujiwara, M.: Impairment of the ex-traneuronal 0-methylating system ofisoproterenol by stop-flow ischemiain the perfused rat heart, 1086

Interleukin 1, antigen presentation,benzo(a)pyrene-induced modulation(mice), 399

Interstitial disease, cyclosporine nephrotox-

icity, alterations, renal structure andfunction (rats), 749

Intestine, absorption of a-methyldopa(rats), 443

Irwin, I., see Finnegan, K. T., 1144Ischemia

effect of minaprine, delayed neuronaldeath (gerbils), 686

extraneuronal uptake, isoproterenol,

heart (rats), 1086myocardial, propranolol effects (dogs),

102redistribution of lysosomal enzymes, in-

hibition by diltiazem, heart (rats),1109

reperfusion and, prostacyclin, concentra-

tion-dependent effects (guinea pigs),292

Ishizaki, T., see Tsujimoto, G., 637Isomazole, vascular relaxation (rats), 864Isoproterenol, extraneuronal uptake, is-

chemic heart (rats), 1086Isradipine, darodipine and, binding to

plasma proteins, blood-brain barrier(rats), 349

Israel, M., see Chuang, L. F., 372

Itoh, H., see Bolt, G. R., 284luvone, P. M., see Johnson, R. D., 842

Jackson, N. M., Hsu, C.-H., Visscher, G. E.,Venkatachalam, M. A. and Humes,H. D.: Alterations in renal structureand function in a rat model of cyclo-

sporine nephrotoxicity, 749Jacobson, K. A., see Evoniuk, G., 882Jacoby, H. I., see Murray, C. W., 500James, M. K. and Leighton, H. J.: Analysis

of putative alpha-is adrenoceptor

agonism by Sgd 101/75 in the ratanococcygeus muscle, 772

James, R. C., Schiefer, M. A., Roberts, S.M. and Harbison, R. D.: Antagonismof cocaine-induced hepatotoxicity bythe alpha adrenergic antagonistsphentolamine and yohimbine, 726

Jardine, I., see Donnerer, J., 583Jenden, D. J., see Ringdahl, B., 464Johanson, C. E. see Chait, L. D., 777

Johnson, R. D., luvone, P. M. and Minne-man, K. P.: Regulation of alpha-iadrenergic receptor density and func-tional responsiveness in rat brain,842

Jones, J. E., see Rubin, R. L., 833

Joselevitz-Goldman, J., Upsher, M. E. andWeiss, H. R.: Effects of propranololon regional 02 supply and 02 con-sumption in reperfused dog myocar-dium, 102

Kageyama, M., see Morimoto, S., 1050

Kainate, dextrorphan and levorphanol,NMDA neurotoxicity, cortical neu-rons, 713

Kainic acid, substance P receptor antago-nist, intrathecal administration,

hemodynamics (rats), 131Kalivas, P. W., Duffy, P. and Latimer, L.

G.: Neurochemical and behavioral ef-fects of corticotropin-releasing factorin the ventral tegmental area of therat, 757

Kamien, J. B., Goldberg, L. I. and Woolver-ton, W. L.: Discriminative stimulusproperties of Dl and D2 dopamineagonists in rats, 804

Kanno, M., see Hattori, Y., 1077Kanaki, H., see Nagase, H., 1120Karmazyn, M., see Basu, D. K., 673Katz, J. L. and Goldberg, S. R.: Psycho-

motor stimulant effects of caffeinealone and in combination with anadenosine analog in the squirrel mon-key, 179

Katz, L. B., Shriver, D. A., Tobia, A. J. andRosenthale, M. E.: Selective gastricantilesion properties of rioprostil, aprostsglandin E1 analog, in rats anddogs, 927

Katz, L. B., Tobia, A. J. and Shriven, D. A.:Effects of ORF 17583, other hista-mine H2-recepton antagonists andomeprazole on gastric acid secretorystates in rats and dogs, 437

Kau, S. T., Howe, B. B., Li, J. H.-Y., Smith,L. H., Keddie, J. R, Barlow, J. J.,Giles, R E. and Goldberg, M. E.: IC!147,798: A novel diuretic agent with

beta adrenoceptor blocking activity,818

Kauffman, R. F., Schenck, K. W., Utter-

1987 Index 1167

back, B. G., Crowe, V. G. and Cohen,M. L.: In vitro vascular relaxation bynew inotropic agents: Relationship to

phosphodiesterase inhibition andcyclic nucleotides, 864

Kavlock, R. J., see Gray, J. A., 212

Kazmi, G. M., see Littner, M. R., 974Keane, W. F., see Sharp, B. M., 579Keddie, J. R., see Kau, S. T., 818Keil, L. C., see Weiskopf, R. B., 970Kenna, J. G., Neuberger, J. and Williams,

R.: Identification by immunoblottingof three halothane-induced liver mi-crosomal polypeptide antigens rec-ognized by antibodies in sera frompatients with halothane-associatedhepatitis, 733

Kestell, P., see Threadgill, M. D., 312Ketamine, phencyclidine and, behavioral

dependence (rats), 203Ketanserin, calcium mechanisms, cerebro-

vascular serotonin receptors (rats),629

Kezdy, F. J., see Cohen, L., 721Kidney, -y-glutamyltranspeptidsse-indepen-

dent uptake, nephrotoxicity, S-(2-chloroethyl)glutathione (rats), 741

Kiechel, J.-R., see Urien, S., 349Kieckens, L., see Stump, D. C., 245Kimura, M., see Araki, H., 686Kindt, M. V., Heikkila, R. E. and Nicklas,

W. J.: Mitochondrial and metabolictoxicity of 1-methyl-4-(2’-methyl-

phenyl)-l,2,3,6-tetrahydropyridine,

858Kindt, M. V., see Sonsalla, P. K., 850Kisara, K., see Sato, T., 654Klaassen, C. D., see Gregus, Z., 27Kohli, J. D., see Bass, A. S., 940Kondo, M., see Nishino, N., 621Kramer, R. A., Foureman, G., Greene, K. E.

and Reed, D. J.: Nephrotoxicity of S-(2-chlorethyl)glutathione in theFischer rat: Evidence for -y-glutamyl-transpeptidsse-independent uptakeby the kidney, 741

Knogsgaard-Larsen, P., see Zorn, S. H., 173Kuczenski, R., see Barnett, J. V., 40Kuczenski, R., see Segal, D. S., 917Kuhar, M. J., see Battaglia, G., 911Kurahashi, K., see Inoue, M., 1086Kuwahara, A., Tien, X.-Y., Wallace, L. J.

and Cooke, H. J.: Cholinergic recep-tors mediating secretion in guinea pigcolon, 600

L-652,731, effects on pulmonary hyperten-sion (sheep), 1035

Labbe, G., see Geneve, J., 1133�-Lactam, transport of benzylpenicillin,

choroid plexus (rats), 660Lafontan, M., see Taouis, M., 1041Laher, I. and Bevan, J. A.: Protein kinase C

activation selectively augmentsstretch-induced, calcium-dependenttone in vascular smooth muscle, 566

Lakshmi, see Mattammal, M. B., 827Lambert, C., Cardinal, R., Venmeulen, M.,

Lamontagne, D., Nadeau, R., Pana-dis, P. and Rouleau, J.-L.: Lack ofrelation between the ventricular re-fractory period prolongation by amio-darone and the thyroid state in rats,320

Lamontagne, D., see Lambert, C., 320

Langer, S. Z., see Hicks, P. E., 1025

Langer, S. Z., see Passarelli, F., 1056Langston, J. W., see Finnegan, K. T., 1144Largent, B. L., see D’Amato, R. J., 364Larrey,D.,seeGeneve,J., 1133

Latimer, L. G., see Kalivas, P. W., 757Leander, J. D., Hart, J. C. and Zerbe, R. L.:

Kappa agonist-induced diuresis: Evi-dence for stereoselectivity, strain dif-

ferences, independence of hydrationvariables and a result of decreasedplasma vasopressin levels, 33

Lederis, K., see Bolt, G. R., 284Lederis, K., see Gan, B. S., 331

Lee, R. W., Raya, T. E., Gay, R. G., Olajos,M. and Goldman, S.: Beta-2 adneno-

ceptor control of the venous circula-tion in intact dogs, 1138

Lefer, A. M., see Bitterman, H., 8Lefevre-Borg, F., see Hicks, P. E., 1025Leighton, H. J. see James, M. K., 772Lemcke, P. K., see Shook, J. E., 1Lestrange, N., see Fine, B. P., 85

Letteron, P., see Geneve, J., 1133Leukemia cells, effect of morpholinyladnia-

mycin analogs, DNA polymerase a,

RNA polymerase II (chickens), 372

Leukocytesadenosine inhibition, immunoglobulin E-

dependent histamine secretion, 1064polymorphonuclear, �-endorphin, stereo-

selective opiate receptor (humans),579

Leukotriene C4, characteristics and bindingsites, bronchi (humans), 1019

Leukotriene D4, myocardial and systemichemodynamic responses, antago-nism, LY171883 (monkeys), 62

Leukotrienes, D-tubocurarine, contraction

and mediator release, trachea and pa-renchymal strips (guinea pigs), 558

Levine, 0. R., see Fine, B. P., 85

Levine, R. A., Zoephel, G. P., Niederwieser,A. and Curtius, H.-C.: Entrance oftetrahydnopterin derivatives in brain

after peripheral administration: Ef-fect on biogenic amine metabolism,514

Levorphanol, dextrorphan and, NMDAneurotoxicity, cortical neurons, 713

Levy, G., see Wanwimolruk, S., 166Li, J. H.-Y., see Kau, S. T., 818

Lidocaine

bupivacaine and, calcium channel block-ade, ventricular muscle (guinea pigs),1001

effect on myocardial acidosis, coronaryartery occlusion (dogs), 1114

indocyanine green and, kinetics, hypox-emia and/or hypercapnia (rabbits),

338Lin, C., McGonigle, P. and Molinoff, P. B.:

Characterization of D-2 dopamine re-ceptors in a tumor of the rat anteriorpituitary gland, 950

Lin, J. H., Chen, I.-W., Ulm, E. H. andDuggan, D. E.: Differential effects ofphenobarbital on ester and ether glu-curonidation of diflunisal in rats,1013

Linden, J., see Clemo, H. F., 478Lindheimer, M. D., see Nagahama, S., 143Lipid peroxidation, nonglucocorticoid ste-

roid analog of methylprednisolone,

central nervous system trauma, neu-

ronal membrane damage (mice), 137

Lipoproteins, darodipine and isradipine,binding, blood-brain barrier (rats),

34915-Lipoxygenase, relaxing effects, arachi-

donic acid, aorta (rats), 945Lisek, C. A., see Donnerer, J., 583Littner, M. R., Kazmi, G. M. and Lott, F.

D.: Effects of A23187, exogenousphospholipase A2 and exogenous ar-achidonic acid on pulmonary vascu-lar resistance in isolated rabbit lung,974

Liver

darodipine and isradipine, binding toplasma proteins, blood-brain barrier

(rats), 349

halothane-associated hepatitis, polypep-

tide antigens (rabbits), 733microvesicular steatosis, mitochondrial �-

oxidation, pirprofen (mice), 1133vitamin D hormonal status, response to

bromobenzene (rats), 354Lott, F. D., see Littner, M. R., 974

Lowenstein, E., see O’Keefe, R. J., 699Lubbers, N., see Bass, A. S., 940Lung

elevated pulmonary vascular tone, alpha-2 adrenoceptor responsiveness(dogs), 158

fetalmetabolic regulation, beta-2 agonist

(sheep), 389tracheal fluid flow, beta-2 agonist

(sheep), 394metabolism of nicotine, prostaglandin H

synthase, mixed-function oxidase(rabbits, humans), 827

D-tubocurarine, contraction and mediatorrelease (guinea pigs), 558

vasoconstniction, A23187, phospholipase

A2 and arachidonic acid (rabbits), 974Lutz, R. A., see Cruciani, R. A., 15LY171555, cardiovascular effects, role of

vasopressin (rats), 143LY171883, antagonism, myocardial and sys-

temic hemodynamic responses, leu-kotriene D4 (monkeys), 62

LY195115, vascular relaxation (rats), 864Lymphocytes, thiopurine methyltransferase

pharmacogenetics, mitogen stimula-tion (humans), 21

Lysosomal enzymes, redistribution inhibi-tion, diltiazem, heart (rats), 1109

Maayani, S., see Clancy, B. M., 108MacCannell, K. L., see Bolt, G. R., 284MacCannell, K. L., see Gan, B. S., 331MacDonald, B. R., see Hahn, R. A., 62Macdonald, R. L., see De Deyn, P. P., 48Maher, E., see Fine, B. P., 85Majchrowicz, E., see Mullin, M. J., 541Manoury, P., see Hicks, P. E., 1025Marleau, S., Ong, H., Gari#{233}py,L. and du

Souich, P.: Lidocaine and indocy-

anine green kinetics: Effect of hypox-emia and/or hypercapnia, 338

Maryanoff, B. E., see Shank, R. P., 74Mathy, M.-J., see Doods, H. N., 257Matsuda, L. A., see Hanson, G. R., 507Matsuda, S. P., see Uotila, P., 945Matsumura, H., see Matsumura, N., 1114Matsumura, N., Matsumura, H. and Abiko,

Y.: Effect oflidocaine on the myocar-

1168 Index Vol. 242

dial acidosis induced by coronary ar-tery occlusion in dogs, 1114

Matsumura, Y., see Morimoto, S., 1050Mattammal, M. B., Lakshmi, V. M., Zenser,

T. V. and Davis, B. B.: Lung prosta-glandin H synthase and mixed-func-tion oxidase metabolism of nicotine,

827

Matthews, H. B., see Ghanayem, B. I., 222Mazindol, reinforcing and subjective effects,

normal human volunteers, 777McCall, J. M., see Hall, E. D., 137McCall, R. B., Patel, B. N. and Harris, L.

T.: Effects of 5-HT1 and 5-HT2 re-

ceptor agonists and antagonists onblood pressure, heart rate and sym-pathetic nerve activity, 1152

McComsey, D. F., see Shank, R. P., 74McDonald, J. W. D., see Smallbone, B. W.,

1035

McGonigle, P., see Lin, C., 950McN-5707, preclinical evaluation, potential

antidepressant (rats), 74

Mei, L., see Wang, J.-X., 981Mei, L., Wang, J.-X., Roeske, W. R. and

Yamamura, H. T.: Thermodynamicanalyses of pirenzepine binding to

membrane-bound and solubilizedmuscarinic receptors from rat fore-

brain and heart, 991

Menduke, H., see Pelleg, A., 791Meningitis, transport of benzylpenicillin,

choroid plexus (rats), 6606-Mercaptopurine, mitogen stimulation,

thiopurine methyltransferase phar-macogenetics (humans), 21

Mercuric chloride, induced renal dysfunc-tion, pharmacological probing, neo-

nates (rats), 212Methamphetamine, induced neurochemical

changes, effects of cocaine (rats), 507Methemoglobin, cyanide antagonists, con-

current carbon monoxide/cyanide in-toxication, antidotal use (mice), 70

Methotrexate, T cell-mediated experimen-tal allergic enccphalomyelitits, phar-macological model (rats), 614

5-Methoxygramine, serotonin receptors, ki-netics of competitive drug action,

aorta (rabbits), 1085- Methoxytyramine, dopamine autorecep-

tors, neocortex (rats), 115

7-Methyl- 1,3-dipropylxanthine, cardiovas-

cular effects (rats), 882N-Methyl-D-aspartate, neurotoxicity, dex-

trorphan and levorphanol, corticalneurons, 713

S-(N-Methylcarbamoyl)glutathione, me-tabolism of N-methylformamide,

deuterium isotope effect (mice), 312

a-Methyldopa, intestinal absorption (rats),443

3,4-Methylenedioxymethamphetamine, 3,4-methylenedioxyamphetamine and,

neurotoxic effects (rats), 911N-Methylformamide, metabolism of, deu-

terium isotope effect (mice), 312Methylmercury, thiols and, biliary and un-

nary excretion, inhibition of -y-glu-

tamyltranspeptidase (rats), 271-Methyl-4-(2’-methylphenyl)- 1,2,3,6-tet-

rahydropyridine

induced neurotoxicity, characteristics

(mice), 850

mitochondrial and metabolic toxicity(mice), 858

N’-Methylnicotinamide, organic cation

transport, neurotoxin substrates,renal brush border membrane vesi-des (dogs), 152

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyri-dine, substrate for organic cationtransporter, renal brush border mem-

brane vesicles (dogs), 1521-Methyl-4-phenylpyridinium, substrate for

organic cation transporter, renalbrush border membrane vesicles

(dogs), 152Methylscopolamine, behavioral effects, an-

timuscarinics (rats), 796

Mezzetti, M., see Civelli, M., 1019

Micheletti, R., see Zorn, S. H., 173Michelson, E. L., see Pelleg, A., 791Microtubules

conversion of taxol to 7-epitaxol, cell cul-

tune medium, 692reduced capacity for rapid axoplasmic

transport, nocodazole (frogs), 277Microvesicular steatosis, mitochondnial fi-

oxidation, pirprofen, fatty acids(mice), 1133

Miller, D. D., see Rice, P. J., 121

Milrinone, vascular relaxation (rats), 864

Minegishi, A., see Tsujimoto, G., 637Minneman, K. P., see Johnson, R. D., 842Mitosis, reduced capacity for rapid axo-

pla�mic transport, nocodazole

(frogs), 277Mitsuoka, T., see Pelleg, A., 791Mixed-function oxidase, prostaglandin H

synthase and, lung metabolism, nic-

otine (rabbits, humans), 827Moffat, M. P.: Concentration-dependent ef-

fects of prostacyclin on the responseof the isolated guinea pig heart toischemia and reperfusion: Possibleinvolvement of the slow inward cur-

rent, 292

Molinoff, P. B., see Lin, C., 950Molliver, M. E., see Battaglia, G., 911Monoamine oxidase, toxicity, i-methyl-

4(2’-methylphenyl)-1,2,3,6-tetrahy-dropyridine (mice), 850, 858

Monoaminescocaine effects, methamphetamine-in-

duced neurochemical changes (rats),507

efflux, L-threo-3,4-dihydnoxyphenylser-

me, brain (guinea pigs), 6213,4-methylenedioxymethamphetamine,

neurotoxic effects (rats), 911Montastruc, P., see Taouis, M., 1041

Moore, S. J., Norris, J. C., Walsh, D. A. and

Hume, A. S.: Antidotal use of met-hemoglobin forming cyanide antago-nists in concurrent carbon monox-ide/cyanide intoxication, 70

Morimoto, S., Matsumura, Y., Sasaki, Y.,Takakuwa, T. and Kageyama, M.:Diuretic effect induced by intrarenal

infusion of pinacidil in anesthetizeddogs, 1050

Morphineendogenous, chemical characterization,

regulation (rats), 583induced antinociception, descending ser-

otononergic and noradrenergic path-ways (mice), 90

kappa opioids, dependence, chronic ad-ministration (monkeys), 428

saline and naltrexone discrimination (pi-geons), 195

Morpholinyladniamycin analogs, effect onDNA polymefuse a, RNA polymeraseII, leukemia cells (chickens), 372

Mr 2033, kappa opioids (monkeys), 413, 428Mullin, M. J., Dalton, T. K., Hunt, W. A.,

Harris, R. A. and Majchrowicz, E.:Actions of ethanol on voltage-sensi-tive sodium channels: Effects of acuteand chronic ethanol treatment, 541

Mullin, M. J. and Hunt, W. A.: Actions ofethanol on voltage-sensitive sodiumchannels: Effects on neurotoxinbinding, 536

Munson, A. E., see Campbell, K. S., 895

Munson, P. J., see Cruciani, R. A., 15Muramatsu, I., Noda, M., Nishio, M. and

Fujiwara, M.: Mechanism of sodiumchannel block in crayfish giant axonsby 711389-5, a new antiarrhythmic

drug, 269Murray, C. W., Cowan, A., Wright, D. L.,

Vaught, J. L., and Jacoby, H. I.: Neu-rokinin-induced salivation in the an-esthetized rat: A three receptor hy-pothesis, 500

Muscleanococcygeus, alpha-lS adrenocepton

agonism, SGD 101/75 (rats), 772relaxant, diazepam, home cage pretreat-

ment (rats), 595ventricular

calcium channel blockade, bupivacaineand lidocaine (guinea pigs), 1001

calcium injury, bepridil (rats), i126Muscle, skeletal

sarcoplasmic reticulum, ryanodine, an-

tithetical calcium channel effects

(rabbits), 56vascular resistance, effects of sufentanil

(dogs), 699Muscle, smooth

airway, verapamil, influence of cartilage(guinea pigs), 450

effect of capsaicin, vas deferens, calci-

tonin gene-related peptide (rats), 666effects of norepinephrine, contraction and

hydrolysis, phosphatidylinositols

(rats),188epidermal growth factor-urogastrone,

transforming growth factor-a, vas-cular actions, 331

vascular

calcium utilization, phorbol dibutyratein aorta (rats), 934

effects of desmethoxyverapamil (guineapigs), 1090

protein kinase C activation, myogenic

tone and TPA (rabbits), 566Myers, M. J., Schook, L. B. and Bick, P. H.:

Mechanisms of benzo(A)pyrene-in-duced modulation of antigen presen-tation, 399

Myocardial depressant factor, protecting ef-fects in hemorrhagic shock, convert-ing enzyme inhibitor, thromboxane

synthetase inhibitor (rats), 8

Myocardium

contractility, mediation, unchanged ye-rapamil, 721

effect of lidocaine on acidosis, coronaryartery occlusion (dogs), 1114

1987 Index 1169

redistribution of lysosomal enzymes, in-hibition, diltiazem (rats), 1109

reperfused, effects of propranolol (dogs),102

systemic hemodynamic responses, leuko-triene D4, antagonism by LY171883(monkeys), 62

Myocytes, anoxic, calcium injury, bepridil(rats), 1126

Myotubesskeletal

chronic ethanol treatment, sodium-po-tassium pump (rats), 1104

effects of ethanol, electrophysiologicalproperties (rats), 1098

Nadeau, R., see Lambert, C., 320Nagahama, S., Ann, H. S., Chen, Y.-F., Lin-

dheimer, M. D. and Oparil, S.: Roleof vasopressin in the cardiovasculareffects of LY17155, a selective dopa-mine D2 receptor agonist: Studies in

conscious Brattleboro and Long-Ev-ans rats, 143

Nagase, H. and Karaki, H.: Palytoxin-in-duced contraction and release ofprostaglandins and norepinephrinein the aorta, 1120

Nakao, Y., see Hattori, Y., 1077

Nakayama, K., see Yamada, S., 320Naloxonazine, interaction ofenkephalin an-

alogs, mu-i/mu/delta opioid binding,

brain (rats), 15Naloxone, acute tolerance to opiates, tem-

poral factors (rabbits), 251

Naltrexone, morphine and saline discrimi-nation (pigeons), 195

Nambi, P., see Aiyar, N., 217Naphthalene oxide, efflux, reactive na-

phthalene metabolites, hepatocytes(mice), 485

l-Naphthol, metabolism of, endocrine reg-ulation (rats), 344

Narumiya, S., Ohno, K., Fukushima, M. andFujiwara, M.: Site and mechanism ofgrowth inhibition by prostaglandins.III. Distribution and binding of pros-taglandin A2 and �12-prostaglandin J2in nuclei, 306

Nawrath, H. and Raschack, M.: Effects of(-)-desmethoxyverapamil on heartand vascular smooth muscle, 1090

Nelson, T. E.: Ryanodine: Antithetical cal-cium channel effects in skeletal mus-cle sarcoplasmic reticulum, 56

Neocortex, dopamine autoreceptors (rats),115

Neonates, mercuric chloride-induced renaldysfunction, pharmacological prob-ing (rats), 212

Neostriatum, dopamine autoreceptors(rats), 115

Nephrotoxicitycyclosporine, alterations, renal structure

and function (rats), 749mercuric chloride-induced renal dysfunc-

tion, pharmacological probing, neo-nates (rats), 212

S-(2-chloroethyl)glutathione (rats), 741

Neubergen, J., see Kenna, J. G., 733Neuhof, H., see Seeger, W., 646Neunoblastoma cells, behavioral effects, an-

timuscarinics (rats), 796Neurokinins, induced salivation, receptors

(rats), 500

Neuronal death, delayed, effect of mina-

pnine (gerbils),686Neurons

benzodiazepine receptor antagonists,CGS 9896 and ZK 91296 (mice), 48

cortical, NMDA neurotoxicity, dextror-

phan and levorphanol, 713enteric, secretion in colon, cholinergic re-

ceptors (guinea pigs), 600

nigrostriatal, dopamine depletion, 1,2,3,6-

tetrahydro-1-methyl-4-(methylpyr-

rol-2-yl)pyridine (mice), 1144sympathetic, serotonin receptor agonists,

antagonists (cats), 1152

Neurotoxicity3,4-methylenedioxymethamphetamine, 3,

4-methylenedioxyamphetamine

(rats), 9111-methyl-4-(2’-methylphenyl)-i,2,3,6-

tetrahydnopyridine-induce d, charac-teristics (mice), 850, 858

NMDA, dextrorphan and levorphanol,cortical neurons, 713

Neurotoxinsbinding sites, actions of ethanol, sodium

channels (rats), 536substrates for organic cation transporter,

renal brush border membrane vesi-

des (dogs), 152Neurotransmission, adrenergic, inhibition,

serotonin exposure (dogs), 493

Neutropenia, effects of L-652,731, pulmo-

nary hypertension (sheep), 1035

Nichols, A. J., Smith, J. M., Jr., Shebuski,

R. J. and Ruffolo, R. R., Jr.: Compar-ison of the effects of the novel mo-tropic agent, ibopamine, with epi-nine, dopamine and fenoldopam on

renal vascular dopamine receptors in

the anesthetized dog, 573Nichols, A. J. and Ruffolo, R. R., Jr.: Eval-

uation of the alpha and beta adreno-ceptor-mediated activities of thenovel, orally active inotropic agent,

ibopamine, in the cardiovascular sys-tem of the pitched rat: Comparisonwith epinine and dopamine, 455

Nicklas, W. J., see Kindt, M. V., 858Nicosia, S., see Civelli, M., 1019

Nicotine

binding sites in brain regions, prenatal

exposure (rats), 232metabolism in lung, prostaglandin H syn-

thase, mixed-function oxidase (nab-

bits, humans), 827Niederwieser, A., see Levine, R. A., 514Nielsen, S. T.: Characterization of the H2

receptor antagonist and gastric acid

antisecretory properties of WY-45,

727, 607Nifedipine, effects of norepinephrine, phos-

phatidylinositols, aorta (rats), 188Nimodipine

calcium channel blockers, prostanoid gen-

eration, vasoconstriction (rabbits),

646calcium mechanisms, cerebrovascular se-

rotonin receptors (rats), 629(R)-Nipecotic acid ethyl ester, cholinergic

profile (guinea pigs, mice, rats), 173Nishikawa, K., see Terashita, Z.-I., 263Nishino, N., Fujii, Y., Kondo, M., Shuntoh,

H., Fujiwara, H. and Tanaka, C.: Ef-fects of L-threo-3,4-dihydroxyphen-

ylserine on efflux of monoamines andacetylcholine in guinea pig brain, 621

Nishio, M., see Munamatsu, I., 269

Nitnoprusside, endothelium-dependent re-laxations, artificial buffered solu-tions, aorta (rabbits), 523

NMDA, see N-Methyl-D-aspartateNocodazole, rapid axoplasmic transport, re-

duced capacity (frogs), 277Nods, M., see Munamatsu, I., 269Nojini, M., see Araki, H., 686Norepinephnine

alpha- 1 receptorsdensity, regulation in brain (rats), 842phosphoinositide hydrolysis (rats), 764

cardiac effects of dopexamine (dogs), 940control of calcium pump (rats), 472effects on contraction and hydrolysis,

phosphatidylinositols, aorta (rats),188

McN-5707, preclinical evaluation, poten-

tial antidepressant (rats), 74morphine-induced antinociception

(mice), 90palytoxin-induced contraction and re-

lease, aorta (rats, rabbits), 1120

sympathoadnenal pressor response, pheo-chromocytoma (rats), 637

Norris, J. C., see Moore, S. J., 70

Nuclei, growth inhibition of prostaglandins,

site and mechanism, 306

O’Donnell, J. M.: Effects of clenbuterol andprenalterol on behavior maintainedunder a multiple fixed-interval,fixed-ratio schedule, 588

Oei,E.,seeAltar,C.A., 115O’Hearn, E., see Battaglia, G., 911

Ohlstein, E. H., see Shebuski, R. J., 158

Ohno, K., see Narumiya, S., 306O’Keefe, R. J., Domalik-Wawrzynski, L.,

Guerrero, J. L., Rosow, C. E., Low-enstein, E. and Powell, W. J., Jr.:Local and neurally mediated effectsof sufentanil on canine skeletal mus-

cle vascular resistance, 699

Olajos, M., see Lee, R. W., 1138Oliva, D., see Civelli, M., 1019Omeprazole, effects of ORF 17583, gastric

acid secretory state (rats, dogs), 437O’Neill, J. T., see Helke, C. J., 131Ong, H., see Marleau, S., 338ONO-6240, CV-6209, antagonist of platelet

activating factor (humans, rabbits),

263Onodera, S., see Ichihara, K., 1109, 1109

Abiko, Y., see Ichihara, K.Oparil, S., see Nagahama, S., 143

Opiatesclonidine hypotension and fl-endorphin,

SHR rats, 378development of acute tolerance, temporal

factors (rabbits), 251Opioids

activities of D-Arg�-substituted tetrapep-tides (mice), 654

fentanyl effects, vasopressin secretion

(humans), 970kappa agonist, diuresis (rats), 33kappa (monkeys), 413, 421, 428morphine/saline/naltrexone discrimina-

tion, morphine treatment (pigeons),

195mu antagonist properties, cyclic somato-

statin octapeptide (mice), 1

1170 Index Vol. 242

mu-i/mu/delta binding sites in brain, in-teraction of enkephalin analogs, na-loxonazine, 15

NMDA neurotoxicity, dextrorphan andlevorphanol, cortical neurons, 713

sufentanil effects, skeletal muscle vascu-lan resistance (dogs), 699

Orband-Miller, L., see Slotkin, T. A., 232ORF 17583, effects on gastric acid secretory

states (rats, dogs), 437

Osiecka, I., Cortese, M., Porter, P. A., Bor-chandt, R. T., Fix, J. A. and Gardner,C. R.: Intestinal absorption of a-

methyldopa: In vitro mechanistic� studies in rat small intestine seg-

ments, 443Osman, R., see Clancy, B. M., 108Ovary cells, Chinese hamster, conversion of

taxol to 7-epitaxol, cell culture me-dium, 692

Owens, S. M., Hardwick, W. C. and Black-all, D.: Phencyclidine pharmacoki-netic scaling among species, 96

Owinan, C., see Chang, J.-Y., 629Owyang, C., see Wiley, J., 548Oxotremorine, somatostatin 14 and musca-

rinic receptor ligands, interaction,

hippocampus (rats), 888Oxotremorine analogs, regional differences

in receptor reserve (mice), 464

Palytoxin, contraction and release of pros-taglandins, norepinephrine and,aorta (rats, rabbits), 1120

Paquette, B., see Urien, S., 349Paradis, P., see Lambert, C., 320

Parenchymal strips, D-tubocuranine, con-

traction and mediator release (guineapigs), 558

Pargyline, dopamine autoreceptors, neocor-tex (rats), 115

Parkinson’s disease, effects of L-threo-3,4-dihydroxyphenylserine, efflux ofmonoamines and acetylcholine, brain

(guinea pigs), 621Parton, L., see Warburton, D., 389, 394Passarelli, F., Galzin, A.-M. and Langer, S.

Z.: Interaction between neuronal up-take inhibitors and presynaptic se-rotonin autoreceptors in rat hypo-thalamic slices: Comparison of K�and electrical depolarization, 1056

Patel, B. N., see McCall, R. B., 1152Patil, P. N., see Rice, P. J., 121

Pearce, W. J. and Bevan, J. A.: Diltiazemand autoregulation of canine cerebralblood flow, 812

Pearson, P. G., see Threadgill, M. D., 312

Pelleg, A., Mitsuoka, T., Michelson, E. L.and Menduke, H.: Adenosine me-diates the negative chronotropic ac-tion of adenosine 5’-triphosphate inthe canine sinus node, 791

Pelton, J. T., see Shook, J. E., 1Pentylenetetrazol, phanmacodynamics, ef-

fects of acute starvation, refeedingand diet composition (rats), 166

Peripheral nervous system, substance P re-ceptor antagonist, intrathecal admin-istration, hemodynamics (rats), 131

Pessayre, D., see Geneve, J., 1133Peters, S., see Choi, D. W., 713Peterson, P. K., see Sharp, B. M., 579

Pharmacogenetics, thiopurine methyltrans-

ferase, mitogen stimulation, lympho-cytes (humans), 21

Pharmacokineticsphencyclidine, scaling among species (pi-

geons), 96urokinase-type plasminogen activator,

single chain forms (humans), 245Phencyclidine

assessment of dependence, oral self-ad-ministration (monkeys), 405

ketamine and, behavioral dependence(rats), 203

pharmacokinetic scaling among species(pigeons), 96

Phenmetrazine, reinforcing and subjectiveeffects, normal human volunteers,777

Phenobarbital

differential effects, ester and ether glu-curonidation, diflunisal (rats), 1013

pharmacodynamics, effects of acute star-vation, refeeding and diet composi-tion (rats), 166

Phentolamine, yohimbine and, antagonism,cocaine-induced hepatotoxicity

(mice), 726Phenylalanine, intestinal absorption of a-

methyldopa (rats), 443

Phenylpropanolamine, reinforcing and sub-jective effects, normal human volun-teers, 777

Pheochromocytoma, sympathoadrenal pres-sor response (rats), 637

Phillips, E. T., see Helke, C. J., 131Phillips, G. R., III, see Bitterman, H., 8Phorbol dibutynate, calcium utilization, pro-

tein kinase C stimulation, aorta(rats), 934

Phosphatidylinositols, contraction and hy-drolysis, effects of norepinephrine,aorta (rats), 188

Phosphoinositide, carbachol-induced turn-

over, cerebellar granule cells, 238Phosphoinositide hydrolysis

alpha-i receptors, norepinephrine regu-

lation (rats), 764relative efficacies of piperazines, seroto-

nergic receptors, 552Phospholipase A2, pulmonary vasoconstnic-

tion (rabbits), 974Pinacidil, diuretic effect (dogs), 1050Pindolol, beta-i partial agonist activity

(rats), 1025Pinquier, J.-L., see Urien, S., 349Pirenzepine

muscaninic receptorskinetic properties of binding, forebrain

and heart (rats), 981thermodynamics, forebrain and heart

(rats), 991Piribedil, discriminative stimulus proper-

ties, Dl and D2 dopamine agonists

(rats), 804Piroximone, vascular relaxation (rats), 864Pirprofen, mitochondrial fl-oxidation, fatty

acids (mice), 1133Pituitary gland, anterior, tumor of, D2 do-

pamine receptors (rats), 950Plasminogen activator, urokinase-type, sin-

gle chain forms, pharmacokinetics

(humans), 245Platelet activating factor

CV-6209 (humans, rabbits), 263effects ofL-652,731, pulmonary hyperten-

sion (sheep), 1035

Ponreca, F., see Shook, J. E., 1Porter, P. A., see Osiecka, I., 443Potassium, electrical stimulation and, scm-

tonin release, hypothalamus (rats),

1056Powell, W. J., Jr., see O’Keefe, R. J., 699Prasad, J. S., see Erickson, R. R., 472

Prazosin, benign prostatic hypertrophy, al-pha-1 adrenoceptors (humans), 326

Prenalterol, clenbuterol and, behavior,fixed-interval/fixed-ratio schedule

. (rats), 588Procainamide, oxidative metabolites, cyto-

toxicity, 833

Prostacyclin, concentration-dependent ef-fects, ischemia and reperfusion, slowinward current (guinea pigs), 292

Prostaglandin H synthase, mixed-functionoxidase and, lung metabolism, nic-

otine (rabbits, humans), 827Prostaglandins

endothelium-dependent relaxations, arti-ficial buffered solutions, aorta (rab-bits), 523

gastric antilesion properties, rioprostil

(rats, dogs), 917

growth inhibition, site and mechanism,306

palytoxin-induced contraction and re-lease, norepinephrine, aorta (rats,

rabbits),1120Prostanoids, calcium antagtonists, vasocon-

striction, lungs (rabbits), 646Prostate, benign prostatic hypertrophy, al-

pha-1 adrenoceptors (humans), 326Protein kinase, metabolic regulation, beta-2

agonist, fetal lung (sheep), 389Protein kinase C

myogenic tone, 12-O-tetradecanoylphor-bol-13-acetate (rabbits), 566

stimulation by phorbol dibutyrate, cal-cium utilization, aorta (rats), 934

Proteolysis, protecting effects in hemon-

rhagic shock, converting enzyme in-

hibitor, thromboxane synthetase in-hibitor (rats), 8

Proudfit, H. K., see Choca, J. I., 905Przuntek, H., see Westarp, M. E., 614Pyrazoloquinolines, benzodiazepine recep-

tor antagonists, CGS 9896 and ZK91296, neurons in culture (mice), 48

Quadazocine, antagonistic actions, kappaopioids (monkeys), 421

Queen, K. L., see Slotkin, T. A., 232Quinpirole, role of vasopressin, cardiovas-

cular effects of LY171555 (rats), 143Quinuclidinyl benzilate, behavioral effects,

antimuscaninics (rats), 796Quisqualate, dextrorphan and levorphanol,

NMDA neunotoxicity, cortical neu-rons, 713

Raeburn, D., Hay, D. W. P., Farmer, S. G.and Fedan, J. S.: Influence of carti-

lage on reactivity and on the effec-tiveness of verapamil in guinea pigisolated airway smooth muscle, 450

Raizada, M. K. see Gonzales, R. A., 764

Ramwell, P. W., see Uotila, P., 945Randall, W. C., see Fee, J. D., 1006Ranitidine, Wy-45,727, characterization,

H2-receptor antagonist (rats, dogs),

607Rapoport, R. M.: Effects of norepinephnine

1987 Index 1171

on contraction and hydrolysis ofphosphatidylinositols in rat aorta,188

Raschack, M., see Nawrath, H., 1090Raya, T. E., see Lee, R. W., 1138Receptor reserve, regional differences, ana-

logs of oxotremorine (mice), 464Receptors

Al and A2 adenosinecardiovascular effects (rats), 882spinal cord (rats), 905

adenosineatnoventricular conduction time, al-

kylxanthines (guinea pigs), 478

CGS 15943A, pharmacological charac-terization (guinea pigs), 784

‘y-aminobutyric acid, chloride channelcomplex, anesthetic drugs (mice), 963

banoreceptor, cardiac effects, dopexamine(dogs), 940

cholinergic

(R)-nipecotic acid ethyl ester (guineapigs, mice, rats), 173

secretion mediation, colon (guineapigs), 600

dopamine Dl and/or D2adenylate cyclase, repeated ampheta-

mine pretreatment (rats), 40anterior pituitary gland tumor (rats),

950cholinergic neurotransmission, stria-

tum (rats), 300discriminative stimulus properties

(rats), 804ibopamine effects (dogs), 573

rectosigmoid motility, domperidone(humans), 548

role of vasopressin, cardiovascualr ef-fects of LY171555 (rats), 143

muscarinicaltered properties, heart and diabetes

(rats), 531analogs of oxotremorine (mice), 464pirenzepine binding, forebrain and

heart (rats), 981, 991

(R)-nipecotic acid ethyl ester (guineapigs, mice, rats), 173

selectivity, muscarinic antagonists

(rats), 251somatostatin 14 interaction, hippocam-

pus (rats), 888muscarinic acetylcholine, phosphoinosi-

tide turnover, cerebellar granulecells, 238

neurokinin, induced salivation (rats), 500nicotinic, binding sites in brain regions,

prenatal nicotine exposure (rats), 232

opiate, �9-endorphin, superoxide produc-tion (humans), 579

opioid mu, cyclic somatostatin octapep-tide (mice), 1

P1-purmoceptors, adenosine, mediation ofATP action (dogs), 791

serotonergic, calcium mechanisms, cere-bral and peripheral arteries (rats),629

serotonin

. efficacies of piperazines, 552

kinetics of competitive drug action,aorta (rabbits), 108

McN.5707, evaluation as antidepres-

sent (rats), 74sympathetic activity (cats), 1152

substance P antagonist, intrathecal ad-

ministration, hemodynamics (rats),131

vasoactive peptide, characterization, sub-mandibular gland (rats), 873

Reed, D. J., see Kramer, R. A., 741Reid, I. A., see Weiskopf, R. B., 970Reperfusion, ischemia and, prostacyclin,

concentration-dependent effects(guinea pigs), 292

Respiratory distress syndrome, effects ofbeta-2 agonist, surfactant, pulmonarymechanics (sheep), 394

Retzinger, G. S., see Cohen, L., 721Ricaurte, G. A., see Finnegan, K. T., 1144Rice, P. J., Hamada, A., Miller, D. D. and

Patil, P. N.: Asymmetric catechol-imidazolines and catecholamidines:

Affinity and efficacy relationships at

the alpha adrenoreceptor in rat aorta,121

Richieri, P. R. and Buckpitt, A. R.: Effluxof naphthalene oxide and reactive na-phthalene metabolites from isolatedhepatocytes, 485

Ringdahl, B., Roch, M. and Jenden, D. J.:

Regional differences in receptor re-serve for analogs of oxotremorine in

vivo: Implications for development ofselective muscarinic agonists, 464

Ringel, I. and Horwitz, S. B.: Taxol is con-

verted to 7-epitaxol, a biologically ac-tive isomer, in cell culture medium,

692Rioprostil, gastric antilesion properties

(rats, dogs), 917

Ritodine hydrochloridemetabolic regulation, fetal lung (sheep),

389tracheal fluid flow, surfactant and pul-

monary mechanics (sheep), 394RNA polymerase II, DNA polymerase a

and, effect of morpholinyladriamycinanalogs, adniamycin (chickens), 372

Ro, J., see Fishleder, R. I., 558Roberts, S. M., see James, R. C., 726Roch, M., see Ringdahl, B., 464Rodbard, D., see Cruciani, R. A., 15Roeske, W. R., see Mei, L., 991Roeske, W. R., see Wang, J.-X., 981R#{246}hrenbach, M., see Seeger, W., 646Rosen, J. I., see Weiskopf, R. B., 970Rosenthale, M. E., see Katz, L. B., 927Rosow, C. E., see O’Keefe, R. J., 699Ross, C. R., see Sokol, P. P., 152Rouleau, J.-L., see Lambert, C., 320Rubin, R. L., Uetrecht, J. P. and Jones, J.

E.: Cytotoxicity of oxidative metab-olites of procainamide, 833

Ruffolo, R. R., Jr., see Nichols, A. J., 455,573

Ruffolo, R. R., Jr., see Shebuski, R. J., 158Ryanodine, antithetical calcium channel ef-

fects, sarcoplasmic reticulum, skele-tal muscle (rabbits), 56

71 1389-5, sodium channel block, giant ax-ons (crayfish), 269

Saito, A., Tomobe, Y. and Goto, K.: Effectof capsaicin on smooth muscles of ratvas deferens: Involvement of calci-tonin gene-related peptide?, 666

Sakuma, I., see Hattori, Y., 1077

Sakurada, S., see Sato, T., 654Sakurada, T�, see Sato, T.,654 -

Saline, morphine and naltrexone discrimi-nation (pigeons), 195

Salivationanalogs of oxotremorine, receptor reserve

(mice), 464neurokinin-induced, receptors (rats), 500

Saluna, T., see Wanburton, D., 389, 394Sampson, S. R., see Brodie, C., 1098, 1104

Sanders-Bush, E., see Conn, P. J., 552Sarcoplasmic reticulum, skeletal muscle, ry-

anodine, antithetical calcium chan-

nel effects (rabbits), 56Sasaki, Y., see Morimoto, S., 1050Sasaki, Y., see Sato, T., 654Sato, T., Sakurada, S., Sakurada, T., Furuta,

S., Chaki, K., Kisara, K., Sasaki, Y.and Suzuki, K.: Opioid activities ofD-arg�-substituted tetrapeptides, 654

Sawada, Y., see Suzuki, H., 660Scaling, phencyclidine (pigeons), 96SCH 23390, cholinergic neurotransmission,

Dl receptor-linked mechanism

(rats),300Schenck, K. W., see Kauffman, R. F., 864Schiefer, M. A., see James, R. C., 726

Schneider, C. R., see Shank, R. P., 74

Schook, L. B., see Myers, M. J., 399Sciatic nerve, reduced capacity for rapid

axoplasmic transport, nocodazole(frogs), 277

Sedation, kappa opioids (monkeys), 413Seeger, W., R#{246}hrenbach, M., Ernst, C. and

Neuhof, H.: Differential influence of

calcium channel-blockers on pros-

tanoid generation and thromboxane-mediated vasoconstriction in rabbitlungs, 646

Segal, D. S., see Barnett, J. V., 40Segal, D. S. and Kuczenski, R.: Individual

differences in responsiveness to sin-gle and repeated amphetamine ad-

ministration: Behavioral character-istics and neurochemical correlates,917

Seiler, M. and Weiss, D. G.: Nocodazoleirreversibly reduces the capacity ofrapid axoplasmic transport in vitro,277

Serotoninagonists and antagonists, efficacies of pi-

perazines, 552effects of cocaine, methamphetamine-in-

duced neurochemical changes (rats),507

effects of receptor agonists and antago-nists, blood pressure, heart rate andsympathetic nerve activity (cats),1152

inhibition of adrenergic neurotransmis-sion, tibial artery (dogs), 493

McN-5707, preclinical evaluation, poten-tial antidepressant (rats), 74

morphine-induced antinociception(mice),90

paroxetine-labeled uptake sites, neuro-toxicity, 3,4-methylenedioxyme-

thamphetamine (rats), 911

receptors, kinetics of competitive drug ac-

tion, aorta (rabbits), 108

release, potassium and electrical stimula-tion, hypothalamus (rats), 1056

uptake, citalopram or imipramine label-ing, brain (rats), 364

Setler, P. E., see Shank, R. P., 74

1172 Index Vol. 242

Sex differences, metabolism of 1-naphthol,endocrine regulation (rats), 344

SGD 101/75, alpha-iS adrenoceptor agon-ism, anococcygeus muscle (rats), 772

Shamim, M. T., see Evoniuk, G., 882Shank, R. P., Gardocki, J. F., Schneider, C.

R., Vaught, J. L., Setler, P. E., Mar-yanoff, B. E. and McComsey, D. F.:Preclinical evaluation of McN-5707

as a potential antidepressant, 74

Sharp, B. M., Tsukayama, D. T., Gekker,G., Keane, W. F. and Peterson, P. K.:j3-Endorphin stimulates human pol-ymorphonuclear leukocyte superox-ide production via a stereoselectiveopiate receptor, 579

Shaw, A. J., see Threadgill, M. D., 312Shebuski, R. J., Ohlstein, E. H., Smith, J.

M., Jr. and Ruffolo, R. R., Jr.: En-hanced pulmonary alpfrw-2 adreno-ceptor responsiveness under condi-tions of elevated pulmonary vasculartone, 158

Shebuski, R. J., see Nichols, A. J., 573Shibutani, T., see Yonehara, N., 1071

Shock, hemorrhagic, protecting effects, con-verting enzyme inhibitor and throm-

boxane synthetase (rats), 8

Shook, J. E., Pelton, J. T., Lemcke, P. K.,Porreca, F., Hruby, V. J. and Burks,T. F.: Mu opioid antagonist proper-

ties of a cyclic somatostatin Octapep-tide in vivo: Identification of mu re-ceptor-related functions, 1

Shriver, D. A., see Katz, L. B., 437, 927Shuntoh, H., see Nishino, N., 621Sinus node, mediation of negative chrono-

tropic action, adenosine, adenosine5’-triphosphate (dogs), 791

Skett, P., see Graham, D. L., 344SKF 38393, discriminative stimulus prop-

erties, Dl and D2 dopamine agonists(rats), 804

Slotkin, T. A., Orband-Miller, L. and Queen,K. L.: Development of [3H]nicotinebinding sites in brain regions of rats

exposed to nicotine prenatally viamaternal injections or infusions, 232

Smallbone, B. W., Taylor, N. E. and Mc-Donald, J. W. D.: Effects of L-652,731, a platelet-activating factor(PAF) receptor antagonist, on PAF-and complement-induced pulmonaryhypertension in sheep, 1035

Smith, J. M., Jr., see Nichols, A. J., 573

Smith, J. M., Jr., see Shebuski, R. J., 158Smith, L. H., see Kau, S. T., 818Snowman, A. M., see D’Amato, R. J., 364Snyder, S. H., see D’Amato, R. J., 364Sodium, repletion, reversal, diuretic-in-

duced growth failure (rats), 85Sodium channel

block, giant axons, 711389-S (crayfish),269

voltage-sensitive, actions of ethanol

(rats), 536, 541Sodium-potassium pump

effects ofchronic ethanol treatment, skel-

etal myotubes (rats), 1104

effects of ethanol, skeletal myotubes(rats), 1098

Sokol, P. P., Holohan, P. D. and Ross, C.R.: The neurotoxins 1-methyl-4-

phenylpyridinium and 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine

are substrates for the organic cation

transporter in renal brush bordermembrane vesicles, 152

Somatostatin, mu opioid antagonist prop-

erties (mice), 1

Somatostatin 14, muscarinic receptor Ii-

gands and, interaction in hippocam-pus, adenylate cyclase modulation

(rats), 888

Sonsalla, P. K., Youngster, S. K., Kindt, M.V. and Heikkila, R. E.: Charactenis-tics of 1-methyl-4-(2’-methyl-

phenyl)-i,2,3,6-tetrahydropropyri-dine-indu ced neurotoxicity in themouse, 850

Spector, S. , see Donnerer, J., 583Sperelakis, N., see Coyle, D. E., 1001

Spinal cordAl and A2 adenosine receptors (rats), 905hemodynamics, substance P receptor an-

tagonist, intrathecal administration

(rats), 131neuronal membrane damage and, nonglu-

cocorticoid steroid analog of methyl-

prednisolone (mice), 137Splenocytes, T-dependent antibody re-

sponse, B subunit of cholera toxin(mice), 895

Starvation, kinetics of drug action in disease

states, phenobarbital, ethanol andpentylenetetrazol (rats), 166

Stassen, F. L., see Aiyar, N., 217Stein, A. F., see Gregus, Z., 27

Stereoisomenism, asymmetric catecholimi-

dazolines and catecholamidines, al-pha adrenoceptor, aorta (rats), 121

Stereotypy, amphetamine-induced, respon-siveness, adenylate cyclase (rats), 40

Steroids, nonglucocorticoid, methylprednis-

olone analog, central nervous systemtrauma and neuronal membranedamage (mice), 137

Stress, effects of corticotropin-releasing fac-tor, ventral tegmental area (rats), 757

Stniatumcholinergic neurotransmission, Di recep-

tor-linked mechanism (rats), 300dopamine depletion, i,2,3,6-tetrahydro-1-

methyl-4-(methylpyrrol-2-yl)pyridine (mice), 1144

Stump, D. C., Kieckens, L., De Cock, F. andCollen, D.: Pharmacokinetics of sin-

gle chain forms of urokinase-type

plasminogen activator, 245

Submandibular gland, vasoactive peptidereceptor binding (rats), 873

Substance Pcontribution to heat-induced edema

(rats), 1071neurokinin-induced salivation (rats), 500receptor antagonist, intrathecal adminis-

tration, hemodynamics (rats), 131

Sufentanil, local and neurally mediated ef-fects, skeletal muscle vascular resist-ance (dogs), 699

Sugiyama, Y., see Suzuki, H., 660

Sullivan, M. J., see Abhold, R. H., 957Sumners, C., see Gonzales, R. A., 764Superoxide, polymorphonuclear leukocyte

production, �i-endorphin, stereoselec-

tive opiate receptor (humans), 579Sunfactant, effects of beta-2 agonist, pul-

monary mechanics (sheep), 394Survival, protecting effects in hemorrhagic

shock, converting enzyme inhibitor,thromboxane synthetase (rats), 8

Suzuki, H., Sawada, Y., Sugiyama, Y., Iga,T. and Hanano, M.: Transport ofbenzylpenicillin by the rat choroidplexus in vitro, 660

Suzuki, K., see Sato, T., 654Sympathectomy, pressor response, pheo-

chromocytoma (rats), 637

Takakuwa, T., see Morimoto, S., 1050Takatani, M., see Terashita, Z.-I., 263Tanaka, C., see Nishino, N., 621Taouis, M., Berlan, M., Montastruc, P. and

Lafontan, M.: Characterization ofdog fat cell adrenoceptors: Variationsin alpha-2 and beta adrenergic recep-tons distribution according to the ex-tent of the fat deposits and the ana-tomical location, 1041

Taxol, conversion to 7-epitaxol, cell culturemedium, 692

Taylor, N. B., see Smallbone, B. W., 1035T cells, pharmacological model for immu-

nosuppressive agents, experimental

allergic encephalomyelitis (rats), 614Terashita, Z.-I., Imura, Y., Takatani, M.,

Tsushima, S. and Nishikawa, K.: CV-6209, a highly potent antagonist ofplatelet activating factor in vitro andin vivo, 263

12-O-Tetradecanoylphorbol- 13-acetate,

myogenic tone, protein kinase C ac-tivation (rabbits), 566

i,2,3,6-Tetrahydno-i-methyl-4-(methylpyr-rol-2-yl)pynidine, depletion of stniataldopamine (mice), 1144

Tetrahydropterin derivatives, entrance inbrain, peripheral administration

(rats), 514Tetrapeptides, D-Arg�-substituted, opioid

activities (mice), 654

Thermodynamics, pirenzepine binding,muscarinic receptors, forebrain andheart (rats), 991

Thiols, methylmercury and, biliary and un-nary excretion, inhibition of y-glu-tamyltranspeptidase (rats), 27

Thiopunine methyltransferase, pharmaco-genetics, effect, mitogen stimulation(humans), 21

Threadgill, M. D., Axworthy, D. B., Baillie,T. A., Farmer, P. B., Farrow, K. C.,

Gescher, A., Kestell, P., Pearson, P.G. and Shaw, A. J.: Metabolism of N-methylformamide in mice: Primarykinetic deuterium isotope effect andidentification of S-(N-methylcarba-

moyl)glutathione as a metabolite, 312

Thrombolysis, urokinase-type plasminogenactivator, single chain forms, phar-

macokinetics (humans), 245Thromboxane, effects of L-652,731, pulmo-

nary hypertension (sheep), 1035Thromboxane synthetase, inhibitor, protec-

tive effects, hemorrhagic shock(rats), 8

Thyroidmetabolism of 1-naphthol, endocrine reg-

ulation (rats), 344ventricular refractory period prolonga-

tion, amiodarone (rats), 320Tien, X.-Y., see Kuwahana, A., 600Tifluadom, kappa agonist-induced diuresis

(rats), 33

1987 Index 1173

Tillement, J.-P., see Urien, S., 349Timmermans, P. B. M. W. M., see Chiu, A.

T., 934

Tobia, A. J., see Katz, L. B., 437, 927Tolerance

actions of ethanol, voltage-sensitive so-dium channels (rats), 541

acute, temporal factors, opiates (rabbits),251

caffeine and adenosine analog, psycho-

motor stimulant effects (monkeys),179

diazepam, home cage pretreatment (rats),

595kappa opioids (monkeys), 413

Tomobe, Y., see Saito, A., 666Trachea, D-tubocurarine, contraction and

mediator release (guinea pigs), 558Transforming growth factor-a, epidermal

growth factor-urogastrone and, vas-cular actions, 331

Tris, endothelium-dependent relaxations,aorta (rabbits), 523

Tsujimoto, G., Minegishi, A., Ishizaki, T.,

Hoffman, B. B. and Hashimoto, K.:Characterization of vasopressor re-sponse to sympathetic stimulation in

the pithed rat: Differential regulationof neuronally stimulated and blood-

borne catecholamine-stimulatedpressor responses in rats harboring

pheochromocytoma, 637Tsukayama, D. T., see Sharp, B. M., 579

Tsushima, S., see Terashita, Z.-I., 263D-Tubocurarine, contraction and mediator

release, trachea and parenchymalstrips (guinea pigs), 558

Turner, J. T. and Bylund, D. B.: Character-ization of the vasoactive intestinal

peptide receptor in rat submandibu-lan gland: Radioligand binding assay

in membrane preparations, 873

Ty, A., see Fine, B. P., 85Tyrosine hydroxylase, tetrahyroptenin de-

rivatives, entrance in brain, periph-

eral administration (rats), 514

U-50,488

kappa agonist-induced diuresis (rats), 33kappa opioids (monkeys), 413, 421, 428

UDP-glucuronyltransferase, diflunisal esterand ether glucuronidation, effects of

phenobarbital (rats), 1013Uetrecht, J. P., see Rubin, H. L., 833Uhlenhuth, E. H. see Chait, L. D., 777

UIm, E. H., see Lin, J. H., 1013Uotila, P., Vargas, R., Wroblewska, B., d’A-

larcao, M., Matsuda, S. P., Corey, E.J., Cunard, C. M. and Ramwell, P.

W.: Relaxing effects of 15-lipoxygen-ase products of arachidonic acid on

rat aorta, 945Upsher, M. E., see Joselevitz-Goldman, J.,

102

Urien, S., Pinquier, J.-L., Paquette, B.,Chaumet-Riffaud, P., Kiechel, J.-R.and Tillement, J.-P.: Effect of thebinding of isradipine and darodipineto different plasma proteins on theirtransfer through the rat blood-brainbarrier. Drug binding to lipoproteinsdoes not limit the transfer of drug,349

Urogastrone, transforming growth factor-a,vascular actions, 331

Urokinase, plasminogen activator, singlechain forms, pharmacokinetics (hu-mans), 245

Urotensin I, alpha adrenoceptor-mediated

pressor responses (rats), 284Ushijima, H., see Yamada, S., 320

Utterback, B. G., see Kauffman, R. F., 864

Vagal control, selective ganglionic blockade,

sinoatrial and atrioventnicular re-gions (dogs), 1006

van Charldorp, K. J., see Doods, H. N., 257Van Loon, J. A. and Weinshilboum, R. M.:

Human lymphocyte thiopurine meth-yltransferase pharmacogenetics: Ef-

fect of phenotype on 6-mencaptopu-rine-induced inhibition of mitogenstimulation, 21

van Zwieten, P. A., see Doods, H. N., 257Vargas, R., see Uotila, P., 945Vascular relaxation, new inotropic agents

(rats), 864

Vascular resistance, skeletal muscle, effects

ofsufentanil (dogs), 699Vas deferens, effect of capsaicin (rats), 666Vasoconstriction

elevated pulmonary vascular tone, alpha-2 adrenocepton responsiveness

(dogs), i58

pulmonary, A23187, phospholipase A2and arachidonic acid (rabbits), 974

thromboxane-mediated, calcium channelblockers, prostanoid generation (rab-

bits), 646Vasodilation

alpha adrenoceptors, pressor responses,urotensin I (rats), 284

effects of sufentanil, skeletal muscle vas-cular resistance (dogs), 699

Vasopressincardiovascular effects of LY171555 (rats),

143effects of N-ethylmaleimide, established

smooth muscle cell line (rats), 217kappa agonist-induced diuresis (rats), 33

secretion, effects of fentanyl (humans),970

Vaught, J. L., see Murray, C. W., 500Vaught, J. L., see Shank, R. P., 74

Venkatachalam, M. A., see Jackson, N. M.,749

Ventral tegmental area, effects of cortico-tropin-releasing factor (rats), 757

Verapamilcalcium antagonists, prostanoids (nab-

bits), 646calcium mechanims, cerebrovascular se-

rotonin receptors (rats), 629

effects of desmethoxyverapamil, heart,

vascular smooth muscle (guineapigs), 1090

influence of cartilage, airway smooth

muscle (guinea pigs), 450

uncharged, mediation, myocardial con-tractility, 721

Vereault, D., see Cohen, L., 721Vermeulen, M., see Lambert, C., 320Viseskul, V., see Choi, D. W., 713Visscher, G. E., see Jackson, N. M., 749Vitamin D, hormonal status, hepatic re-

sponse, bromobenzene (rats), 354Vohl, M. L., see Westarp, M. E., 614Vos, P., Davenport, P. A., Artymyshyn, R.

P., Fraser, A. and Wolfe, B. B.: Se-lective regulation ofbeta-2 adrenergic

receptors by the chronic administra-

tion of the lipophilic beta adrenergic

receptor agonist clenbuterol: An au-toradiographic study, 707

Wallace, L. J., see Kuwahara, A., 600Walsh, D. A., see Moore, S. J., 70Wang, J.-X., Mei, L., Yamamura, H. I. and

Roeske, W. R.: Solubilization withdigitonin alters the kinetics of piren-zepine binding in muscarinic recep-

tons from rat forebrain and heart, 981Wang, J.-X., see Mei, L., 991Wanwimolruk, S. and Levy, G.: Kinetics of

drug action in disease states. XX.

Effects of acute starvation on thepharmacodynamics of phenobarbital,ethanol and pentylenetetrazol in rats

and effects of refeeding and diet com-position, 166

Warburton, D., Parton, L., Buckley, S., Cos-ico, L. and Saluna, T.: Effects of beta-

2 agonist on tracheal fluid flow, sur-

factant and pulmonary mechanics in

the fetal lamb, 394Warburton, D., Parton, L., Buckley, S., Cos-

ico, L. and Saluna, T.: Effects of beta-2 agonist on metabolic regulation inthe fetal lamb lung, 389

Wassenstrom, J. A., see Cohen, L., 721Weinshilboum, R. M., see Van Loon, J. A.,

21Weinstock, M., see Hovav, E., 251Weiskopf, R. B., Reid, I. A., Fisher, D. M.,

Holmes, M. A., Rosen, J. I. and Keil,L. C.: Effects of fentanyl on vaso-

pressin secretion in human subjects,970

Weiss, D. G., see Seiler, M., 277

Weiss, H. R., see Joselevitz-Goldinan, J.,102

Wekerle, H., see Westarp, M. E., 614Westarp, M. E., Wekerle, H., Ben-Nun, A.,

Cohen, I. R., Vohl, M. L. and Przun-tek, H.: T-lymphocyte line-mediatedexperimental allergic encephalomye-litis-a pharmacologic model fortesting of immunosuppressive agentsfor the treatment of autoimmunecentral nervous system disease, 614

Wigdor, S. and Wilcox, G. L.: Central andsystemic morphine-induced antino-ciception in mice: Contribution of de-scending serotonergic and noradre-nergic pathways, 90

Wilcox, G. L., see Wigdor, S., 90Wiley, J. and Owyang, C.: Dopaminergic

modulation of rectosigmoid motility:Action of domperidone, 548

Will, J. A., see Fishleder, R. I., 558

Williams, M., see Ghai, G., 784Williams, R., see Kenna, J. G., 733Winger, G., see Dykstra, L. A., 413, 421

Winkler, M. E., see Gan, B. S., 331Withdrawal, morphine/saline/naltrexone

discrimination, morphine treatment(pigeons), 195

Witkin, J. M., Gordon, R. K. and Chiang,P. K.: Comparison of in vitro actions

with behavioral effects of antimus-

carinic agents, 796Wolfe, B. B., see Vos, P., 707

Wood, P. L., see Altar, C. A., 115

Woods, J. H., see Dykstra, L. A., 413, 421Woods, J. H., see France, C. P., 195

1174 Index Vol. 242

Woods, J. H., see Gmerek, D. E., 428Woolverton, W. L., see Kamien, J. B., 804Wright, D. L., see Murray, C. W., 500Wright, J. W., see Abhold, R. H., 957Wroblewska, B., see Uotila, P., 945

Wu, C. F., see Consolo, S., 300Wurster, R. D., see Fee, J. D., 1006Wurtman, R. J., see Evoniuk, G., 882

Wy-45,727, gastric acid antisecretory prop-

erties, characterization, H2-recepton

antagonist (rats, dogs), 607

Xamoterolbeta-i partial agonist activity (rats), 1025cardiac effects (guinea pigs), 1077

Xu, J. and Chuang, D.-M.: Muscarinic ace-tylcholine receptor-mediated phos-phoinositide turnover in cultured cer-

ebellar granule cells: Desensitizationby receptor agonists, 238

Yamada, S., Ashizawa, N., Ushijima, H.,

Nakayama, K., Hayashi, E. and

Honda, K.: Alpha-i adrenoceptors in

human prostate: Characterization

and alteration in benign prostatic hy-pertrophy, 326

Yamamura, H. I., see Wang, J.-X., 981Yamamura, H. T., see Mei, L., 991Yeh, S. Y., see Battaglia, G., 911

YM-12617, benign prostatic hypertrophy,

alpha-i adrenoceptors (humans), 326Yohimbine

morphine-induced antinociception

(mice), 90phentolamine and, antagonism, cocaine-

induced hepatotoxicity (mice), 726Yonehara, N., Shibutani, T. and Inoki, R.:

Contribution of substance P to heat-induced edema in rat paw, 1071

Yonkers, P. A., see Hall, E. D., 137

Younes, A., see Cruz, C., 1126Youngster, S. K., see Sonsalla, P. K., 850Yu, M., see Chuang, L. F., 378, 372 Mas-

trianni, J. A. and Ingenito, A. J.: On

the

Zaoui,A.,seeCruz,C., 1126Zenser, T. V., see Mattammal, M. B., 827

Zenbe, R. L., see Leander, J. D., 33Zimmerman, M. B., see Ghai, G., 784Zoephel, G. P., see Levine, R. A., 514

Zorn, S. H., Duman, R. S., Giachetti, A.,Micheletti, R., Giraldo, E., Knogs-

gaard-Larsen, P. and Enna, S. J.: (R)-Nipecotic acid ethyl ester: A direct-acting cholinergic agonist that dis-

plays greater efficacy at M2 than atM1 muscarinic receptors, 173

Zymosan, effects of L-652,731, pulmonaryhypertension (sheep), 1035