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Statement of Ownership, Management, and Circulation (All Periodicals Publications Except Requester Publications) 1. Publication Title: Pharmacological Reviews. 2. Publication Number: 0031-6997. 3. Filing Date: September 8, 2008. 4. Issue Frequency: quarterly in March, June, September, and December. 5. Number of Issues Published Annually: 4. 6. Annual Subscription Price: $256.00. 7. Complete Mailing Address of Known Office of Publication: American Society for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20814-3995. Contact Person: Richard Dodenhoff. Telephone: 301-634-7997. 8. Complete Mailing Address of Headquarters or General Business Office of Publisher: American Society for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20814-3995. 9. Full Names and Complete Mailing Addresses of Publisher, Editor, and Managing Editor: Publisher: American Society for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20814-3995. Editor: Dr. Ross D. Feldman, Robarts Research Institute, PO Box 5015, Stn. B, 100 Perth Dr., London N6A 5K8, ON, Canada. Managing Editor: Jill Filler, American Society for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20814-3995. 10. Owner: American Society for Pharmacology & Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20814-3995. 11. Known Bondholders, Mortgagees, and Other Security Holders Owning or Holding 1 Percent or More of Total Amount of Bonds, Mortgages, or Other Securities: None. 12. Tax Status: The purpose, function, and nonprofit status of this organization and the exempt status for federal income tax purposes: Has Not Changed During Preceding 12 Months. 13. Publication Title: Pharmacological Reviews. 14. Issue Date for Circulation Data: June 2008. 15. Extent and Nature of Circulation: Average No. Copies Each Issue During Preceding 12 Months: a. Total Number of Copies: 1,182. b. Paid Circulation: (1) Mailed Outside-County Paid Subscriptions Stated on PS Form 3541: 641. (2) Mailed In-County Paid Subscriptions Stated on PS Form 3541: 0. (3) Paid Distribution Outside the Mails Including Sales Through Dealers and Carriers, Street Vendors, Counter Sales, and Other Paid Distribution Outside USPS®: 306. (4) Paid Distribution by Other Classes of Mail Through the USPS: 0. c. Total Paid Distribution: 947. d. Free or Nominal Rate Distribution: (1) Free or Nominal Rate Outside-County Copies Included on PS Form 3541: 11; (2) Free or Nominal Rate In-County Copies Included on PS Form 3541: 0; (3) Free or Nominal Rate Copies Mailed at Other Classes Through the USPS: 0; (4) Free or Nominal Rate Distribution Outside the Mail: 5. e. Total Free or Nominal Rate Distribution: 16. f. Total Distribution: 963. g. Copies not Distributed: 220. h. Total: 1,182. i. Percent Paid: 98.3641. No. Copies of Single Issue Published Nearest to Filing Date: a. Total Number of Copies: 990. b. Paid Circulation: (1) Mailed Outside-County Paid Subscriptions Stated on PS Form 3541: 551; (2) Mailed In-County Paid Subscriptions Stated on PS Form 3541: 0; (3) Paid Distribution Outside the Mails Including Sales Through Dealers and Carriers, Street Vendors, Counter Sales, and Other Paid Distribution Outside USPS®: 256; (4) Paid Distribution by Other Classes of Mail Through the USPS: 0. c. Total Paid Distribution: 807. d. Free or Nominal Rate Distribution: (1) Free or Nominal Rate Outside-County Copies Included on PS Form 3541: 11; (2) Free or Nominal Rate In-County Copies Included on PS Form 3541: 0; (3) Free or Nominal Rate Copies Mailed at Other Classes Through the USPS: 0; (4) Free or Nominal Rate Distribution Outside the Mail: 4. e. Total Free or Nominal Rate Distribution: 15. f. Total Distribution: 822. g. Copies not Distributed: 168. h. Total: 990. i. Percent Paid: 98.1752. 16. Publication of Statement of Ownership If the publication is a general publication, publication of this statement is required. Will be printed in the September 2008 issue of this publication. 17. Signature and Title of Editor, Publisher, Business Manager, or Owner: Richard C. Dodenhoff II, Journals Director. September 8, 2008. I certify that all information furnished on this form is true and complete. I understand that anyone who furnishes false or misleading information on this form or who omits material or information requested on the form may be subject to criminal sanctions (including fines and imprisonment) and/or civil sanctions (including civil penalties).

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A Renaissance in Marine Pharmacology: Preclinical Curiosity to Clinical Reality

Advances in Down Syndrome Neuroscience Research: Implications for Alzheimer'sDisease, Dementias, & Other Cognitive Disorders

All Presidents' Symposium on Integrative Pharmacology

AMPK as a Novel Therapeutic Approach for the Treatment of Metabolic Disorders & Heart Disease

Discovery & Development of Oligonucleotide Therapeutics

Emerging Approaches to Treatment of Alzheimer’s Disease

Endothelial Progenitor Cells & Cardiovascular Disease - From Bench to Bed Site

Exposure to Environmental Agent Alters Epigenetic Homeostasis

Gases as Neuromodulators in Sensing: From Nitric Oxide to Hydrogen Sulfide

Generating Proteomic Diversity in Xenobiotic Biotransformation with Alternative RNA Splicing

Integrating Basic Sciences & Patient Care in a Core Clerkship Curriculum

Metabolomics in the Search for Biomarkers for Human Health

microRNAs as Biological Effectors & as Pharmacological Targets in the Cardiovascular System

Neuroplastic & Neurodegenerative Changes Associated with Drug Abuse and Addiction

Receptor Signaling & Regulation in Neuropsychiatric Research

Regenerative Pharmacology

Regulation of Xenobiotic Metabolizing Enzymes in Humans: Implications for thePropagation of Health & Disease

Targeting Drug Metabolizing Enzymes for Effective Chemopreventive Approaches

The Role of Nuclear Receptors in Lipid Homeostasis

The Role of Insulin & Leptin in Drug Addiction and Mood

The Serotonin Transporter: Non Just for Neurons Anymore

Therapeutics in Autoimmunity: Treatment Successes & Side Effects as a Tool ofElucidating Pathogenic Pathways

Virally-encoded G Protein Coupled Receptors as New Drug Targets?

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