JOURNAL OF VIROLOGYVOLUME 48 NUMBER 3 DECEMBER 1983

Edward M. Scolnick, Editor in Chief (1987)Merck Sharp & Dolime Research Laboraitories

Wes.t Point, Pa.David T. Denhardt, Editor (1987)University of Western OntarioLondon, Ontario, Canada

Bernard N. Fields, Editor (1988)Harvard University, Medical School

Boston, Mass.

Harold S. Ginsberg, Editor (1984)Coluimbia UniversityNew York, N.Y.

Robert M. Krug, Editor (1987)Sloan-Kettering Institute

New York, N.Y.

Michael B. A. Oldstone, Editor (1988)Sc ripps Clinic & Research Fouindation

La Jolla, Calif.

Robert A. Weisberg, Editor (1988)National Institlute of Child Health and Human Development

Bethesda, Md.

David Baltimore (1984)Amiya K. Banerjee (1985)Andrew Becker (1985)Tamar Ben-Porat (1984)Kenneth I. Berns (1985)David Botstein (1985)Dennis T. Brown (1984)Ahmad I. Bukhari (1984)Barrie J. Carter (1984)Purnell Choppin (1983)John M. Coffin (1983)Geoffrey M. Cooper (1984)Walter Doerfler (1983)Harrison Echols (1984)Elvera Ehrenfeld (1983)Robert N. Eisenman (1985)Suzanne U. Emerson (1983)S. Jane Flint (1984)Yasuhiro Furuichi (1985)Costa Georgopolous (1983)Larry M. Gold (1985)Peter Gruss (1985)Hidesaburo Hanafusa (1983)William S. Hayward (1984)John J. Holland (1984)Ian H. Holmes (1983)Robert W. Honess (1983)Nancy Hopkins (1983)Peter M. Howley (1984)

EDITORIAL BOARDAlice S. Huang (1984)Tony Hunter (1983)Masayori Inouye (1985)Robert Kamen (1985)Thomas J. Kelly, Jr. (1985)George Khoury (1984)Elliott Kieff (1984)Jonathan A. King (1984)Daniel Kolakofsky (1983)Robert Lamb (1985)Robert A. Lazzarini (1984)Myron Levine (1985)Douglas R. Lowy (1983)Robert Martin (1984)George Miller (1984)Lois K. Miller (1985)Robert C. Miller (1983)Peter Model (1983)Bernard Moss (1983)Nancy G. Nossal (1984)J. Thomas Parsons (1983)Ulf G. Petterson (1983)Lennart Philipson (1984)Lewis I. Pizer (1984)Craig R. Pringle (1983)Fred Rapp (1984)Dan S. Ray (1983)M. E. Reichmann (1985)Gordon M. Ringold (1984)

Harriet Robinson (1985)William S. Robinson (1983)Bernard Roizman (1985)Roland R. Rueckert (1985)Norman P. Salzman (1984)Joseph Sambrook (1985)Priscilla A. Schaffer (1984)Sondra Schlesinger (1983)June R. Scott (1983)Bart Sefton (1985)Phillip A. Sharp (1985)Thomas E. Shenk (1984)Charles J. Sherr (1984)Saul J. Silverstein (1985)Lee D. Simon (1984)Ann Skalka (1985)Patricia G. Spear (1984)Mark F. Stinski (1983)F. William Studier (1984)Lawrence S. Sturman (1985)Jesse Summers (1985)William Summers (1985)John M. Taylor (1984)Howard M. Temin (1985)George F. Vande Woude (1983)Edward K. Wagner (1983)Eckard Wimmer (1985)Charles Hamish Young (1983)

Helen R. Whiteley, Chairman, Publications BoacrdLinda M. Illig, Managing Editor, Jouirnals

Walter G. Peter III, Direc tor, PublicationsPaula R. Ellison, Production Editor

The Journal of Virology (ISSN 0022-538X), a publication of the American Society for Microbiology, 1913 1 St., NW.Washington, DC 20006, is devoted to the dissemination of fundamental knowledge concerning viruses of bacteria, plants, andanimals. Investigators are invited to submit reports of original research in all areas of basic virology, including biochemistry.biophysics, genetics, immunology, morphology, physiology, and pathogenesis and immunity. Instructions to authors arepublished in the January issue each year; reprints are available from the editors and the Publications Office. The Jollrnlal is issuedmonthly, four volumes per year. The nonmember subscription price is $225 per year; single copies are $20. The membersubscription price is $37 (foreign, $44 [surface ratel) per year; single copies are $7.00. Correspondence relating to subscriptions,reprints, defective copies, availability of back issues, lost or late proofs. disposition of submitted manuscripts, and generaleditorial matters should be directed to the ASM Publications Office, 1913 I St., NW, Washington, DC 20006 (area 202 833-9680).

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Author Index

Aasted, Bent, 573Andersen, Klaus B., 765Appella, Ettore, 709

Banks, L., 591Baric, Ralph S., 633Barker, Peter E., 770Bishop, J. Michael, 565Bloom, Marshall E., 573Boone, Lawrence R., 779Bornkamm, G. W., 731Brackmann, Karl H., 604Brewer, Gregory J., 774Buekens, Pierre, 697

Cogniaux-LeClerc, Jacqueline, 697Cohen, G., 591Cooper, Jonathan A., 752Costa, R. H., 591Cywinski, Anita, 654

Dalianis, Tina, 709DesGroseillers, Luc, 685Draper, K. G., 591

Eisenberg, R., 591

Foster, David A., 744Freese, U. K., 731Fuchs, L. Yolanda, 641

Garcia, Ernesto, 721Garon, Claude F., 573Ghisotti, Daniela, 616G6mez, Antonio, 721Goto, Ronald M., 774Green, Maurice, 604

Hamagishi, Yasutaro, 709Hanafusa, Hidesaburo, 744Henry, Berch, II, 580Hood, Rachel, 580Hudewentz, J., 731Hughes, Stephen H., 667Hunter, Tony, 752

Ito, Yoshiaki, 709

Jolicoeur, Paul, 685

Kahlon, Jasbir, 627Klempnauer, Karl-Heinz, 565Koh, Chong-kun, 779Koprowski, Hilary, 660Kramer, Tammo A., 604

Lai, Michael M. C., 633Laux, G., 731Lee, Donald, 647Levis, Robin, 676L6pez, Rubens, 721Lucher, Lynne A., 604

Mayer, Leonard W., 573

Olislager, Roland, 697Ou, Chin-yih, 779Ozanne, Brad, 752

Pagano, Joseph S., 580Powell, K. L., 591

Raab-Traub, Nancy, 580Reagan, Kevin J., 660

Ricci, William, 667Ronda, Concepci6n, 721Roussel, Martine F., 770Roy, Polly, 627Ruddle, Frank H., 770

Sadowski, Paul D., 647Schlesinger, Sondra, 676Schwarz, E., 731Scolnick, Edward M., 752Segawa, Kaoru, 709Sherr, Charles J., 770Sironi, Gianpiero, 616Smith, Julie K., 654Sorge, Joe, 667Sprecher-Goldberger, Suzanne,697

Stohlman, Stephen A., 633Sugiyama, Kazuo, 627Symington, Janey S., 604

Taylor, John M., 654Tennant, Raymond W., 779Thiry, Lise, 697

Wagner, E. K., 591Weaver, Robert F., 641Weiss, Barbara, 676Wiktor, Tadeusz J., 660Willingham, Mark, 709Woods, Michael S., 641Wunner, William H., 660

Yang, Czau-Siung, 580Yang, Wen K., 779

Zangrossi, Sandro, 616

ACKNOWLEDGMENT

The following have served as invited special reviewers for the Journal during 1983, and their helpis greatly appreciated.

Stu AaronsonSankar AdhyaRafi AhmedCharles A. Alford, Jr.James AlwineRobert AndersonSteven AndersonRalph ArlinghausRichard ArmentroutRichard AxelHoward L. BachrachJohn BaderGeorge BaerCorrado BaglioniL. Andrew BallMarcel BaludaMariano BarbacidJ. Richard BaringerSamuel BaronRenato BasergaClaudio BasilicoRobert BassinKaren BeemanThomas BenjaminArnold BerkAnna BialkowskaDavid BishopMichael BishopKlaus BisterDonald BlairBarry BloomMarshall E. BloomDavid BoettingerDani BolognesiMichael BotchanPierre BourgauxJoan BruggeMichael BuchmeierSteven BurakoffHoward BusseyJanet ButelBruce CalnekRobert B. CarrollEric B. CarstensSherwood CasjensEsther ChangRobert ChanockLan Bo ChenCraig CohenGary H. CohenCharles ColePhilip ColemanRichard ColonnoRichard W. CompansJon CondraLouis Z. CooperRichard J. CourtneyRichard L. CrowellClyde Crumpacker

Diane CuppelsSamuel DalesVittorio DefendiMel DePamphilisRavi DharJules L. DienstagDan DimaioGeorge DimayorcaDino DinaMartin E. DorfR. Gordon DouglasWalter DowdleGordon DreesmanGideon DreyfusPeter DuesbergWalter EckhartJohn ElderRon EllisFrancis A. EnnisLynne EnquistMarcia J. EnsingerLois B. EpsteinH. Gunti ErdlRaymond EriksonMax EssexMary Kolb EstesAnthony S. FauciGerald FinkJames B. FlaneganErwin FleissnerStephen C. FosterMichael M. FrankRobert FriedmanTed FriedmanMark FurthRobert GalloAnthony GarroE. Peter GeidushekWalter GerhardJohn L. GerinAnne A. GershonMary Jane GethingRaymond GildenW. Paul GlezonLaurie GlimcherYosha GluzmanNigel GodsonSteve GoffAngus GrahamFrank L. GrahamHarry B. GreenbergMark I. GreeneTerry GrodzigerCharles F. GroseAshley T. HaaseMary HaffeyGordon HagerJules HallumScott B. Halstead

Berg HamparDaniel HardyJanet HartleyWilliam HaseltineJohn HassellStanley HattmanAnne M. HaywoodAri HeleniusRoger HendrixRoger HewittLawrence HightowerMaurice R. HillemanShalom Z. HirschmanMonto HoJohn J. HollandF. Blaine HollingerJohn A. HolowczakMarshall HorwitzSally HuberJoe HughesJerry HurwitzRichard HymanJames N. IhleMark IsraelYoshiaki ItoGilbert JayRichard T. JohnsonWolfgang JoklikDavid KabatAlbert KapikianRobert S. KauffmanVicki E. KelleyD. C. KellyEli KeshetEdwin D. KilbourneSaul KitDavid KnipeChristine KozakD. H. KrugerEdward KuffMichael LaiRonald A. LaskeyPaul LebowitzPhillip LederStanley S. LefkowitzRobert I. LehrerJohn LenardPeter LengyelArnold J. LevineMichael LevineArt LevinsonMichael LiebowitzFrank LillyTomas LindahlDavid LinemeyerMaxine LinialDavid LivingstonHarvey LodishCarlos Lopez

J. Lucas-LenardGeorge MackieTak MakKirstine MannEleftheria Maratos-FlierDante MarcianiPhilip MarcusStuart MarcusMalcolm MartinPhilip E. McAllisterWilliam McClementsDonald McCorquodaleDale McFarlinTravis C. McGuire, Jr.Kenneth McIntoshRoger McMackenDonald N. Medearis, Jr.Pamela MellonJoseph MelnickThomas C. Merigan, Jr.Barry 1. MilavetzThomas P. MonathJohn MoorheadGisela MosigRichard MoxonBrian MurphyRobert MurrayA. J. NahmiasOpendra NarayanDan NathansNeal NathensonPaul E. NeimanAbner L. NotkinsJohn F. ObijeskiPaul O'DonnellLloyd OldAllen OliffSteve OroszlanJune E. OsbornMichael N. OxmanJoseph PaganoPeter PaleseEnzo PaolettiWade ParksRobert H. ParrottJames PenningtonJanice PeroSidney PestkaBruce A. PhillipsPaula PithaBernard PoieszRobert Pollack

David PorterPoteeteKenneth L. PowellCarol PrivesRobert PurcellPaul G. QuieCharles RaddingCedric RaineR. Frank RamigSaraiya RasheedWilliam RawlsAlan ReinJack S. RemingtonRoberta ReubenMarkus RhoadesSolon Rhode IIIMark RiemenWilliam S. RobinsonGeorge RohrmannJohn RoseMartin RosenbergNaomi RosenbergLanny J. RosenwasserBarry RouseMartine RousselWallace RoweFrank RuddleKathleen RundellSandra RuscettiPhilip K. RussellMartin RutaPaul SadowskiCharles E. SamuelAndreas S. ScheidR. Walter SchlesingerStuart F. SchlossmanLoren SchultzRobert S. SchwartzArup SenGanes SenJohn L. SeverDavid ShafritzArlene SharpeAaron J. ShatkinRobert E. ShopeSteven L. ShoreMaxine SingerN. K. SinhaLarry SnyderDennis StaceyJack StevensWilliam E. Stewart 11

Bruce W. StillmanSteven E. StrausJames StraussJack L. StromingerMax D. SummersStanley TaharaKenneth TakemotoIgor TammPeter J. TattersallPeter TegtmeyerGretchen TemelesIrwin TessmanMary J. R. TevethiaSatvir TevethiaRobert ThachDennis TrentStephen UdemBernard van der JeistJames Van EttenHarold VarmusLeland F. VelicerInder VermaJan T. VilcekPeter VogtRobert WagnerDuard L. WalkerJack WandsJoseph WeberMichael WeberSteven L. WechslerRobert WeinbergHoward WeinerLeslie P. WeinerDavid WeinsteinRobin WeissSusan WeissSherman WeissmanRaymond M. Welsh, Jr.Reed WicknerJim WilliamsOwen WitteLinda WolffH. A. WoodWilliam WunnerRichard WyattKeith YamamotoRobert H. YolkenFaith YoshimuraHoward YoungJulius YoungnerStuart YuspaHans J. Zweerink

INDEX TO DATE OF ISSUE

Date of Issue

20 September 198321 October 198317 November 1983

U.S. rstlS-ric.

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TITlE OF PugLICATION 1B. PUBLICATION NO. 2 DATE OF FILING

Journal of Virology 30 September 19833FROENeO ISSUE 3 OO SUSPBIHD3 NULSBCITO

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Mootthly 12 $37 mbr, 0225 nonmbr"COMPLETE MAILING ADDRESS OF KNOWN OFFICE OF PUBLICATION (S010e,. CY,y. CFuFy. SOFFOFFd ZFPCodOF INOFpriFtrtJ

1913 I Street, N.W., Washington, D.C. 200065 COMPLETE MAILING ADDRESS OF THE HEADOUARTERS OF GENERAL BUSINESS OFFICES OF THE PUBLISHER INtFopSFFO)

1913 1 Street, N.W., Washington, D.C. 20006

FUIL NAMESAND COMPLETE MAILING ADDRESS OF PUBLISHER, EDITOR. AND MANAGING EDITOR IOFOIFFO F8USTNOrb, bDOFk

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American Society for Microbiology, 1913 1 Street, N.W., Washington, D.C. 20006

EDITOR (NF-F FdCo-pFMF011Add-FsDirector of PublicationsWalter G. Peter III, 1913 I Street, N.W., Washington, D.C. 20006

MANAGING EDITOR CN--OFend C-pl-r MFIIFF. Addr,-)F

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8 KNOWN BONDHOLOERS, MORTGAGEES, AND OTHER SECURITY HOLDERS OWNING OR HOLDING PERCENT OR MORE OF TOTALAMOUNT OF BONDS, MORTGAGES OR OTHER SECURITIES /1f-So n

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12 MONTHS FILING DATE

A TOTAL NO COPIES(Nf PF,- R,I 7614 7838

8 PAID CIRCULATION (Member)S0.,F h,oFuF d.FIFF F FFIFF dFF0 .F.FItulF 2836 3101

?R2FM, S cOFFF io,Fb,F (Nonmember) 1449 1657

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D FREE DISTRIBUTION BY MAIL, CARRIER OR OTHER MEANSSAMPLES, COMPLIMENTARY, AND OTHER FREE COPIES 100 100

|LEFTOTAL DISTRIBUTION FSF0 ofCo-d DI 4385 4858F COPIE! NOT DISTRIBUTEO

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i 1 N) SIGNAT0F E AND TITLE OF EDITOR, PUBLISHER. BUSINESS MANAGER, OR OWNERcertify that the statements made by I ,./4'

me above are correct and complete L7FI>0 Aj( s

Month

OctoberNovemberDecember

Pages

1-334335-564565-785

PS FormJ.', 19i82 3526 (See inlstruction ont revwrse)

AUTHOR INDEX

VOLUME 48

Aasted, Bent, 573Aboud, Mordechai, 120Ahola, Harri, 370Akusjarvi, G., 127Anders, David G., 197, 206Andersen, Klaus B., 765Anderson, Carl W., 31Appella, Ettore, 709Ariga, Hiroyoshi, 481Arnold, Georg, 157Atkinson, Paul H., 335

Bachi, Thomas, 239Banks, L., 591Baric, Ralph S., 633Barker, Peter E., 770Barnett, Jim W., 384Barrett, Kathleen J., 157Bates, Robert C., 10Bellamy, A. Richard, 335Betz, Joan L., 460Bishop, J. Michael, 565Bister, Klaus, 61Blanck, George, 492Bleumink, Nancy, 249, 262Blinkova, Aleksandra, 157Blissard, Gary W., 74Bloom, Marshall E., 573Boccara, Martine, 102Bodemer, Walter, 377Boeye, Albert, 309Boone, Lawrence R., 110, 779Bornkamm, G. W., 731Both, Gerald W., 52, 335Brackmann, Karl H., 604Bratt, Michael A., 440Brewer, Gregory J., 774Brugge, Joan S., 352Brzustowicz, Linda, 555Buekens, Pierre, 697Burke, Julian F., 304

Campadelli-Fiume, Gabriella, 325Campbell, Bruce A., 561Carlson, Karin, 18Carter, Barrie J., 79Chambraud, B., 127Chan, Hardy W., 384Chen, Suzie, 492Cheung, Andrew, 451Chowdhury, Kamal, 40Cogniaux-LeClerc, Jacqueline, 697Cohen, G., 591Cohen, Gary H., 521Collett, Marc S., 320Collins, Lisa, 542Consigli, Richard A., 197, 206Cooper, Jonathan A., 752

Cords, Carl E., 561Costa, R. H., 591Costanzo, Franco, 325Costanzo, Maria, 555Cox, Nancy J., 52Crawford, Lionel V., 262Cywinski, Anita, 654

Dalianis, Tina, 709Dall'Olio, Fabio, 325Dasgupta, Asim, 429DeLamarter, John, 451DePamphilis, Melvin L., 281DesGroseillers, Luc, 685Dietrich, Walter, 377Dorsett, Dale L., 218Draper, K. G., 591Dunn, John J., 31Dyall-Smith, Michael L., 330

Eisenberg, R., 591Eisenberg, Roselyn J., 521Emini, Emilio A., 547Ensinger, Marcia J., 419Eppstein, Deborah A., 384Evans, Mary Jo, 304

Favre, Michel, 340Feitelson, Mark A., 534Fleckenstein, Bernhard, 377Fleissner, Erwin, 102Fleming, Jo-Ann G. W., 74Folk, William R., 472Foster, David A., 744Freese, U. K., 731Fuchs, L. Yolanda, 641

Ganem, Don, 1Garcfa, Ernesto, 721Garon, Claude F., 40, 573Gerhard, Walter, 239Ghisotti, Daniela, 616Ghosh, Prabhat K., 503Gibson, Marylou G., 396Gilardi, P., 127G6mez, Antonio, 721Goto, Ronald M., 774Graessmann, A., 296Graessmann, M., 2%Grass, David S., 492Green, Maurice, 604Grinnell, Brian W., 88

Hamagishi, Yasutaro, 709Hanafusa, Hidesaburo, 744Hannett, Nancy, 555

Hardy, Medora M., 31Hayashi, Marie N., 186Hayashi, Masaki, 186Hayward, S. Diane, 135Henderson, Louis E., 314Henry, Berch, II, 580Hoganson, Neal, 492Holmes, Ian H., 330Hood, Rachel, 580Horzinek, Marian C., 249Huberman, Joel A., 304Hudewentz, J., 731Hughes, Stephen H., 667Huleihel, Mahmoud, 120Hunter, Tony, 752

Ikura, Koji, 460Iorio, Ronald M., 440Israel, Mark A., 40Ito, Yoshiaki, 709

Jablonska, Stefania, 340Jansen, Hans W., 61Jeang, Kuan-Teh, 135Jentoft, J., 361Jolicoeur, Paul, 685

Kahlon, Jasbir, 627Kantharidis, Phillip, 330Kendal, Alan P., 52Keshet, Ilana, 218, 229Klempnauer, Karl-Heinz, 565Klessig, Daniel F., 31Knight, Susan S., 534Knust, Elisabeth, 377Koh, Chong K., 110Koh, Chong-kun, 779Koprowski, Hilary, 660Kozak, Christine A., 300Kramer, Tammo A., 604Kremsdorf, Dina, 340Kupper, Hans, 451

Lai, Michael M. C., 633Larson, Ruby, 320Laub, Orgad, 271Laux, G., 731Lavie, Vered, 229Lederman, Muriel, 10Lee, Donald, 647Leis, J., 361Le Moullec, J. M., 127Levis, Robin, 676Lewis, Anita J., 352Lipsich, Leah A., 352Lomax, Nancy B., 410

i

ii AUTHOR INDEX

L6pez, Rubens, 721Lucher, Lynne A., 604

Magarian, Claudette, 102Manley, James L., 492Marcus-Sekura, Carol J., 79Margolskee, Robert F., 405Marion, Patricia L., 534Matthews, James T., 521Mayer, Leonard W., 573McBeth, Dani L., 149McKinney, Martin D., 551Mirault, Marc-Edouard, 249Mirenda, Carol, 542Moreno-Lopez, Jorge, 370Morrow, Casey D., 429Muller, Uwe R., 170, 180, 186Myer, Fred E., 110

Nasri, M., 127Nathans, Daniel, 405Norkin, Leonard C., 503Noyes, Barbara E., 249

Oliff, Allen, 542Olislager, Roland, 697Oroszlan, Stephen, 314Orth, Gerard, 340Oshiro, Lyndon S., 534Ostapchuk, Philomena, 547Osterhaus, Albert D. M. E., 249Ou, Chin-Yih, 110Ou, Chin-yih, 779Ozanne, Brad, 752

Pagano, Joseph S., 580Parker, Barbara, 249Patschinsky, Tilo, 61Pero, Janice, 555Perricaudet, M., 127Pettersson, U., 127Pettersson, Ulf, 370Piatak, Michael, 503Pizer, Lewis I., 460Plummer, M. Joan, 304Pollack, Robert E., 492

Powell, K. L., 591Purchio, A. F., 320

Raab-Traub, Nancy, 580Rall, Leslie B., 271Reagan, Kevin J., 660Ricci, William, 667Roberson, Laurence E., 110Robinson, William S., 534Romantschuk, Martin L., 180Ronda, Concepci6n, 721Rothwell, Victoria M., 472Roussel, Martine F., 770Rovinsky, Michael, 419Roy, Polly, 627Ruddle, Frank H., 770Rutter, William J., 271

Sadler, John R., 460Sadowski, Paul D., 647Scannavini, Maurizia, 325Schlesinger, Sondra, 676Schwarz, E., 731Scolnick, Edward M., 752Seeger, Christoph, 1Segawa, Kaoru, 709Serafini-Cessi, Franca, 325Shaul, Yosef, 271Sherr, Charles J., 770Siegman, Linda J., 335Sironi, Gianpiero, 616Sleigh, Merilyn J., 52Smith, Julie K., 654Smythers, Gary, 314Sorge, Joe, 667Souyri, Michele, 102Sowder, Raymond, 314Spear, Patricia G., 396Sprecher-Goldberger, Suzanne,697

Stalhandske, P., 127Standring, David N., 271Stark, George R., 249, 262Stavnezer, Edward, 102Stenlund, Arne, 370Stohlman, Stephen A., 633Stout, Ernest R., 10Sugano, Sumio, 481

Sugiyama, Kazuo, 627Summers, Max D., 74Swyryd, Elizabeth A., 249, 262Symington, Janey S., 604

Tack, Lois C., 281Taylor, Austin L., 149Taylor, John M., 654Tennant, Raymond W., 110, 779Thiry, Lise, 697Thomas, Adri A. M., 309Truett, Martha, 271Tsubota, Yoriaki, 304

Valenzuela, Pablo, 271van der Zeijst, Bernard A. M.,

249, 262Varmus, Harold E., 1Vinson, S. Bradleigh, 74Voorma, Harry O., 309

Wagner, E. K., 591Wagner, Robert R., 88Waqar, M. Anwar, 304Weaver, Robert F., 641Wechsler, James A., 551Weiser, Barbara, 1Weiss, Barbara, 676Weiss, Stephen, 451Weissman, Sherman M., 503Westphal, H., 2%Wiberg, John S., 18Wiktor, Tadeusz J., 660Willingham, Mark, 709Wimmer, Eckard, 547Winocour, Ernest, 218, 229Woods, Michael S., 641Wunner, William H., 660

Yang, Czau-Siung, 580Yang, D. M., 110Yang, Wen K., 110, 779Yewdell, Jonathan W., 239Yin, Fay H., 410

Zangrossi, Sandro, 616

J. VIROL.

SUBJECT INDEX

VOLUME 48

Adeno-associated viruschromatin-like structure of DNA, 79

Adenovirustype 2DNA-binding protein gene, 31independent, spontaneous mutants, 31major late transcription unit, 127monkey cells, 31polyadenylic acid addition sites, 127simian virus 40 hybrid, 31

Aleutian disease virusantigen expressionrecombinant plasmid, 573

molecular cloning, 573recombinant plasmid

antigen expression, 573Antibody

anti-idiotypicrabies virus glycoprotein, 660

antipeptidehuman adenovirus 2 ElB-19K tumor antigen, 604human adenovirus 2 ElB-53K tumor antigen, 604

monoclonalanti-hemagglutinin, 239avian sarcoma virus transforming proteins, 352baboon endogenous virus cell receptors, 697group B coxsackieviruses, 561influenza virus A/PR/834, 239inhibition of virus attachment, 561irreversible antigenic alterations, 239Newcastle disease virus, 440

neutralizingrabies virus glycoprotein, 660

nonapeptide, 709poliovirus

bivalent attachment, 547conformational alteration and neutralization, 547genome-linked protein VPg, 429NH2 terminus, 429synthetic nonapeptide, 429

polyomavirus, 709Antigen

Aleutian disease virusrecombinant plasmid, 573

middle Tnonapeptide, 709polyomavirus, 709

super Tsimian virus 40, 492transformed mouse cells, 492

surfaceduck hepatitis B virus, 534hepatitis B virus, 271major polypeptide, 534synthesis in mammalian cells, 271

Tearly replicating DNA intermediates, 281simian virus 40 chromosome complexes, 281

tumorantipeptide antibodies, 604human adenovirus 2 EIB-19K, 604human adenovirus 2 ElB-53K, 604

4utographa californicanuclear polyhedrosis virus

novel RNA polymerase, 641S. frugiperda cells, 641viral transcription, 641

Avian myeloblastosis virusc-myb transduction

cellular gene, 565points of recombination, 565

Avian oncovirusMH2

molecular cloning of proviral DNA, 61structural analysis of viral RNA and protein, 61

Avian retrovirusDNA discontinuities, 654ppl2 protein

interaction with viral RNA, 361Avian sarcoma virusmonoclonal antibodies

transforming proteins, 352transforming proteinsmonoclonal antibodies, 352

Baboon endogenous viruscell receptorsmonoclonal antibodies, 697

monoclonal antibodiescell receptors, 697

BacteriophageCp-l

protease-sensitive transfection of S. pneumoniae,721

G4DNA secondary structure modifications, 170enzymatic construction and selection of mutants,

170gene expression, 180J-F intercistronic region, 170, 180, 186mRNA stability, 186mutations, 180

lambdadnaB protein, 551P protein, 551replication, 551RNA polymerase interaction, 551

MuE. coli K-12 DNA polymerase I, 149growth, 149

P4a gene, 157RNA polymerase, 157

P2-xinterference by E. coli, 616

4X174gene expression, 180J-F intercistronic region, 180, 186mRNA stability, 186mutations, 180simian virus 40 recombinant genomes, 229

PM2gram-negative host, 774

iii

iv SUBJECT INDEX

phosphatidylethanolamine accessibility, 774SPO1gene 27, 555

T4cytosine, 18in vivo cleavage, 18

T7direct physical assay, 647in vitro DNA recombination, 647

BHK cellslymphocytic choriomeningitis virus

persistent infection, 262RNAs, 262viral proteins, 262

Sindbis virusdefective-interfering RNAs, 678persistent infection, 678virus RNAs, 678

Bluetongue virusneutralization

molecular basis, 627Bovine cells

bovine viral diarrhea virusvirus-specific RNA, 320

Bovine parvovirusproteins, 10

Bovine viral diarrhea virusbovine cells

virus-specific RNA, 320

Campoletis sonorensis virusparasitized host Heliothis virescens, 74

Carcinomanasopharyngeal

Epstein-Barr virus transcription, 580Cellular transcription

inhibitionvesicular stomatitis virus, 88

ChickensFujinami sarcoma virus

tumors, 744Rous sarcoma virus

tumors, 744tumors

Fujinami sarcoma virus, 744Rous sarcoma virus, 744

Chromatinadeno-associated virus DNA structure, 79

Chromosomehuman 5

assignment of c-fms locus, 770molecular cloning of c-fms locus, 770

Chromosomesreplicating simian virus 40

a-like DNA polymerase, 304in vitro DNA synthesis, 304

simian virus 40 T-antigen complexes, 281Coxsackievirusgroup B

inhibition of attachment, 561monoclonal antibodies, 561

Cytosinebacteriophage T4

in vivo cleavage, 18

Duck hepatitis B virussurface antigenmajor polypeptide, 534

Electron microscopymicroinjected simian virus 40

spliced cRNA, 296Epidermodysplasia verruciformishuman papillomavirus 8, 340human papillomavirus 10, 340human papillomavirus 3a, 340human papillomavirus 12, 340

Epstein-Barr virusabortive cycle

transcription of two distant clusters of partiallyhomologous small repeats, 731

DNA molecule organizationmRNA transcript, 135Notl repeat units, 135P3HR-I deletion junction, 135template, 13512-O-tetradecanoylphorbol-13-acetate, 135

lytic cycletranscription of two distant clusters of partially

homologous small repeats, 731nasopharyngeal carcinoma

transcription, 580transcription

nasopharyngeal carcinoma, 580Escherichia coli

bacteriophage P2-A interference, 616K-12

bacteriophage Mu growth, 149DNA polymerase I, 149

Eucaryotic cellsherpes simplex virus

class I defective DNA, 384European Elk papillomavirus

characterization of genome, 370induction of tumors in animals, 370transformation in vitro, 370

Exonucleasealkaline

herpes simplex virus type 1, 591

Feline sarcoma virusSnyder-Theilen

epidermal growth factor receptor metabolism, 752human A431 cells, 752protein kinase activity, 752

Foot-and-mouth disease virusserotypesmajor antigenic determinants, 451

Friend mink cell focus-inducing virusmolecular cloningnormal cells, 542transformed cells, 542

normal cellsmolecular cloning, 542

transformed cellsmolecular cloning, 542

Fujinami sarcoma virusfps gene

free of gag gene sequences, 744

J. VIROL.

SUBJECT INDEX v

induction of tumors in chickens, 744transformation of cells in culture, 744

Glycosylationsimian rotavirus SA 1I gene segment 10noncleaved signal peptide, 335

Ground squirrel hepatitis viruslivers

asymmetrical heterogeneous forms, Iclosed circular viral DNA, I

Hamster tumor cell lineintegrated polyomavirus DNA

structural analysis, 40Heliothis virescens

parasitized hostC. sonorensis virus, 74

Hemagglutinininfluenza virus A/PR/834

acid activation of hemolysis, 239mediation of hemolysis, 239monoclonal antibodies, 239

influenza virus H3antigenic drift, 52multiple evolutionary pathways, 52sequential amino acid changes, 52

monoclonal antibodiesinfluenza virus A/PR/834, 239irreversible antigenic alterations, 239

Hemolysisinfluenza virus A/PR/834

acid activation, 239mediation, 239

Hepatitis B virussurface antigen

expression of coding region, 271expression of entire gene, 271synthesis in mammalian cells, 271

Herpes simplex virusclass I defective DNA

eucaryotic cells, 384molecular cloning vehicle, 384

eucaryotic cellsclass I defective DNA, 384

insertion mutantsduplication of glycoprotein D gene, 396two forms of glycoprotein D, 396

type Ialkaline exonuclease, 591capsid protein, 591glycoprotein D synthesis and processing in vitro,

521glycoproteins, 325high-resolution characterization of transcripts,

591N-acetylgalactosaminyltransferase activity, 3250-glycosylation, 325short unique region, 460SmaI fragment, 460transcribed RNAs, 460

type 2glycoprotein D synthesis and processing in vitro,

521

Herpesvirus saimiritransformed lymphoid tumor cell line

virus-specific transcription, 377Human A431 cellsHarvey murine sarcoma virus

epidermal growth factor receptor metabolism, 752protein kinase activity, 752

Kirsten murine sarcoma virusepidermal growth factor receptor metabolism, 752protein kinase activity, 752

Snyder-Theilen feline sarcoma virusepidermal growth factor receptor metabolism, 752protein kinase activity, 752

Human adenovirus2

antipeptide antibodies, 604COOH terminus, 604EIB-19K tumor antigen, 604EIB-53K tumor antigen, 604NH2 terminus, 604

Human papillomavirus8

biochemical characterization, 340epidermodysplasia verruciformis, 340molecular cloning, 340

10biochemical characterization, 340epidermodysplasia verruciformis, 340molecular cloning, 340

3abiochemical characterization, 340epidermodysplasia verruciformis, 340molecular cloning, 340

12biochemical characterization, 340epidermodysplasia verruciformis, 340molecular cloning, 340

Human rhinovirushost range mutants

altered nonstructural proteins, 410

Influenza virusA/PR/834

acid activation of hemolysis, 239irreversible antigenic alterations, 239mediation of hemolysis, 239monoclonal anti-hemagglutinin antibodies, 239

H3 hemagglutininantigenic drift, 52multiple evolutionary pathways, 52sequential amino acid changes, 52

Interferonretrovirus

inhibition of DNA supercoiling, 120

Leupeptinmouse fibroblasts

inhibition of retrovirus infection, 765retrovirus

inhibition of infection in mouse fibroblasts, 765Lymphocytic choriomeningitis virusBHK cells

persistent infection, 262RNAs, 262viral proteins, 262

VOL. 48, 1983

vi SUBJECT INDEX

persistent infectionBHK cells, 262intracellular agent, 249standard cell lines, 249

standard cell linespersistent infection, 249

Lymphoid tumor cell lineH. saimiri-transformed

virus-specific transcription, 377

Mammalian cellshepatitis B surface antigen

synthesis, 271Mink cell focus-forming virusmouse chromosomal locus

genetic mapping, 300replicationmouse chromosomal locus, 300

Monkey cellsadenovirus type 2-simian virus 40 hybrid

adenovirus type 2 DNA-binding protein gene, 31independent, spontaneous mutants, 31

Mouse fibroblastsleupeptin

inhibition of retrovirus infection, 765retrovirus

inhibition of infection by leupeptin, 765Mouse hepatitis virus

replicative-intermediate RNAleader RNA sequences, 633nascent chains, 633

Mouse lymphoid cellsleukemic

retrovirus env transcript, 102normal

retrovirus env transcript, 102Mouse mammary tumor virusenv gene products

proteolytic cleavage sites, 314terminal amino acid sequences, 314

Murine leukemia virusBALB/c

physical mapping of Fv-1 tropism host rangedeterminant, 685

BALB/c B-tropicFv-1 host range property, 779nucleotide sequences of gag-pol regions, 779

BALB/c N-tropicFv-1 host range property, 779nucleotide sequences of gag-pol regions, 779

B-tropicgenome, 110in vitro restriction endonuclease fragment ex-

change, 110molecular clone, 110reversal of Fv-1 host range, 110

N-tropicgenome, 110in vitro restriction endonuclease fragment ex-

change, 110molecular clone, 110reversal of Fv-1 host range, 110

Murine sarcoma virusHarveyepidermal growth factor receptor metabolism, 752human A431 cells, 752

protein kinase activity, 752Kirsten

epidermal growth factor receptor metabolism, 752human A431 cells, 752protein kinase activity, 752

N-Acetylgalactosaminyltransferaseherpes simplex virus type I glycoproteins, 325

Newcastle disease virusepitopes

monoclonal antibodies, 440HN glycoproteinmonoclonal antibodies, 440

monoclonal antibodiesfour epitopes, 440HN glycoprotein, 440

Nuclear polyhedrosis virusA. californica

novel RNA polymerase, 641S. frugiperda cells, 641viral transcription, 641

0-glycosylationherpes simplex virus type I glycoproteins, 325

Phosphatidylethanolamineaccessibility in bacteriophage PM2 and gram-nega-

tive host, 774Phosphorylationpolyomavirus major capsid protein VPI, 206

Plasmidrecombinant

Aleutian disease virus antigens, 573Poliovirus

antibodybivalent attachment, 547conformational alteration and neutralization, 547genome-linked protein VPg, 429

genome-linked protein VPgantibody, 429NH2 terminus, 429synthetic nonapeptide, 429

in vitro RNA replicationinhibition, 429

native VPg, 429NH2 terminusgenome-linked protein VPg, 429

specific proteinssynthesis and cleavage, 309

synthetic nonapeptidegenome-linked protein VPg, 429

Polyadenylic acidadenovirus type 2 major late transcription unit

addition sites, 127PolyomavirusA2comparison with polyomavirus Crawford small-

plaque variant, 472antibodies

cross-reaction with cellular protein(s), 709middle T antigen, 709nonapeptide, 709

cellular protein(s)

J. VIROL.

SUBJECT INDEX vii

antibodies, 709middle T antigen, 709

Crawford small-plaque variantcomparison with polyomavirus A2, 472comparison with polyomavirus strain 3, 472DNA sequence, 472

integrated DNAhamster tumor cell line, 40structural analysis, 40

major structural protein VPIcarboxy-terminal region, 197chemical cleavage, 197cleavage products, 197major phosphorylation region, 206nonphosphorylated species, 206phosphorylated species, 206receptor moiety, 197

middle T antigenantibodies, 709cross-reaction with cellular protein(s), 709nonapeptide, 709

nonapeptideantibodies, 709middle T antigen, 709

strain 3comparison with polyomavirus Crawford small-

plaque variant, 472Protease

bacteriophage Cp-l DNAtransfection of S. pneumoniae, 721

S. pneumoniaetransfection by bacteriophage Cp-l DNA, 721

Protein kinaseHarvey murine sarcoma virushuman A431 cells, 752

human A431 cellsHarvey murine sarcoma virus, 752Kirsten murine sarcoma virus, 752Snyder-Theilen feline sarcoma virus, 752

Kirsten murine sarcoma virushuman A431 cells, 752

Snyder-Theilen feline sarcoma virushuman A431 cells, 752

Rabies virusanti-idiotypic antibodies

glycoprotein, 660glycoprotein

anti-idiotypic antibodies, 660neutralizing antibodies, 660

neutralizing antibodiesglycoprotein, 660

Restriction endonucleasefragment exchange in vitro

murine leukemia virus genomes, 110reversal of Fv-l host range, 110

RetrovirusDNA supercoiling

inhibition in interferon-treated cells, 120env transcriptleukemic mouse lymphoid cells, 102normal mouse lymphoid cells, 102

interferon-treated cellsinhibition of DNA supercoiling, 120

leupeptininhibition of infection in mouse fibroblasts, 765

mouse fibroblastsinhibition of infection by leupeptin, 765

RotavirusSAIIgene coding assignments, 330gene products, 330segments 7, 8, and 9, 330

Rous sarcoma virus115-nucleotide direct repeat

cis-acting RNA packaging locus, 667Schmidt-Ruppin-A

induction of tumors in chickens, 744src gene, 744transformation of cells in culture, 744

Serinesimian virus 40 VPI mutantcodons, 405

Simian rotavirusSAIIcoding assignment, 335gene segment 10, 335glycosylation sites, 335noncleaved signal peptide, 335nucleotide sequence, 335

Simian virus 40adenovirus type 2 hybridDNA-binding protein gene, 31independent, spontaneous mutants, 31monkey cells, 31

bacteriophage OX174 recombinant genomessingle cells, 229structure, 229

chromosome-T-antigen complexesearly replicating DNA intermediates, 281

functional origin of replicationsuper T antigen generation, 492transformed mouse cells, 492

in vitro DNA replicationinitiation, 481

late mRNA forms5' end sequences, 503

microinjectedelectron microscopy, 296spliced cRNA, 2%

nonhomologous recombination pathwayquantitation, 218

replicating chromosomesa-like DNA polymerase, 304in vitro DNA synthesis, 304

super T antigen generationfunctional origin of replication, 492transformed mouse cells, 492

transformed mouse cellsfunctional origin of replication, 492super T antigen generation, 492

VPI mutantmissense mutations, 405serine codons, 405suppression, 405viral agnogene, 405

Sindbis virusBHK cells

defective-interfering RNAs, 678persistent infection, 678

VOL. 48, 1983

viii SUBJECT INDEX

virus RNAs, 678persistent infectionBHK cells, 678defective-interfering RNAs, 678virus RNAs, 678

Spodoptera frugiperda cellsA. californica nuclear polyhedrosis virus

novel RNA polymerase, 641viral transcription, 641

Streptococcus pneumoniaebacteriophage Cp-l DNA

protease-sensitive transfection, 721protease-sensitive transfection

bacteriophage Cp-l DNA, 721Supercoiling

interferon-treated cellsinhibition, 120

retrovirus DNAinhibition, 120

12-O-Tetradecanoylphorbol- 13-acetateEpstein-Barr virusmRNA transcript, 135

Transformed mouse cellssimian virus 40

functional origin of replication, 492super T antigen generation, 492

Tumorschickens

Fujinami sarcoma virus, 744Rous sarcoma virus, 744

European Elk papillomavirus, 370Fujinami sarcoma virus

chickens, 744Rous sarcoma virus

chickens, 744

Vaccinia virusWR

correlation of genetic and physical maps, 419marker rescue, 419temperature-sensitive mutations, 419

Vesicular stomatitis virusserotype Indiana

inhibition of cellular transcription, 88viral leader RNA, 88

serotype New Jerseyinhibition of cellular transcription, 88viral leader RNA, 88

Viral leader RNAvesicular stomatitis virus

inhibition of cellular transcription, 88serotype Indiana, 88serotype New Jersey, 88

J. VIROL..