jessica agee, meredith bowers, deletra harmon, stevie leonard, brittany nelson & jamie womack
TRANSCRIPT
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THE CHINA STUDY: A CLOSER LOOK AT BREAST CANCER RISK, HORMONES & DIET
Jessica Agee, Meredith Bowers, Deletra Harmon, Stevie Leonard, Brittany Nelson & Jamie Womack
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THESIS
Does an animal based diet elevate sex hormones?
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THESIS(CONTD.)
Are hormone levels related to greater breast cancer risk?
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DIET AND HORMONES
“Diet and Sex Hormones in Girls” Dorgan, Hunsberger, McMahon, Kwiterovich,
Lauer, Van Horn, Lasser, Stevens, …Taylor Randomized Controlled Clinical Trial Adolescent girls consumed low-fat, low
animal-based foods for seven yrs. Results: diet lowered estrogen levels (20-
30%) Limitations
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DIET AND HORMONES
“Dietary Fat Reduction and Plasma Estradiol Concentration in Healthy Postmenopausal Women” Prentice, Thompson, Clifford, Gorbach, Goldin &
Byar 73 postmenopausal women Results: when consumption of daily dietary
fat fell upwards to 50%, levels of estrogen went down
Limitations
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DIET AND HORMONES
“Changes in Sex Hormone-Binding Globulin, Insulin, and Serum Lipids in Postmenopausal Women on a Low-Fat, High-Fiber Diet Combined with Exercise” Tumchuk, Tessler & Banard
Does a low-fat, high-fiber diet with exercise affect post-menopausal women’s hormone levels?
Results: SHBG levels increased Insulin decreased Serum lipid levels decreased
Limitations
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DIET AND HORMONES
“Reduction of Serum Estradiol in Postmenopausal Women Given Free Access to a Low Fat, High Carbohydrate Diet” Heber, Ashley, Leaf & Barnard
Thirteen postmenopausal women had access to a low-fat diet
Results: estrogen levels decreased Limitations
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HORMONES AND BREAST CANCER
“Reproductive Factors and Breast Cancer” Kelsey, Gammon, John
A literary review Examines correlation with increased
estrogen levels and risks of breast cancer No Results Limitations
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HORMONES AND BREAST CANCER
“Western diet and western diseases: some hormonal and biochemical mechanisms and association” H. Adlercruetz
Literary Review Connections between diet and Western diseases
Results: A Western diet with high-fat and protein intake and a low intake of fiber and complex carbohydrates and whole grains is associated with high plasma sex hormone levels
Limitations
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CONCLUSION
Outdated Irrelevant Not generalizable Correlation Doesn’t prove causation
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REFERENCESAdlercruetz, H. (1990). Western diet and Western diseases; some hormonal and biochemical
mechanisms and associations. Scandinavian journal of clinical & laboratory investigation, 50, 3-
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Campbell, T. C., & Campbell, T. M. (2006). The China Study: Startling Implications for Diet, Weight
Loss, and Long-term Health. Dallas, TX: Benbella Books, Inc.
Dorgan, J.F., Hunsberger, S.A., McMahon, R.P., Kwiterovich, P. O., Lauer, R. M., Van Horn, L.,
Lasser, N. L., Stevens, V. J., …Taylor, P. R. (2003) Diet and sex hormones in girls: findings from a
randomized controlled clinical trial. Journal of the National Cancer Institute. 95(2), 132-141.
Dorgan, J. F., Longcope, C., Stephenson, H., Falk, R. T., Miller, R., Franz, C., Kahle, L., Campbell, W.
S., Tangrea, J. A., & Schatzkin, A., (1996) Relation of prediagnostic serum estrogen and androgen
levels to breast cancer risk. Cancer Epidemiology, Biomarkers & Prevention, 5, 533-539
Heber, D., Ashley, J. M., Leaf, D. A., & Barnard, R. J. (1991) Reduction of serum estradiol in
postmenopausal women given free access to low fat, high carbohydrate diet. Nutrition, 7(2) 137-
139.
Kelsey, J.L., Gammon, M.D., & John, E.M. (1993). Reproduction factors and breast cancer.
Epidemiologic Reviews, 15(1), 36-47.
Prentice, R., Thompson, D., Clifford, C., Gorbach, S., Goldin, B., & Byar, D. (1990). Dietary fat
reduction and plasma estradiol concentration in healthy postmenopausal women. Journal of the
National Cancer Institute, 82, 129-134
Tumchuk, C. N., Tessler, S. B., & Banard, R. J. (2000). Changes in sex hormone-binding globulin,
insulin, and serum lipids in postmenopausal women on a low-fat, high-fiber diet combined with
exercise. Nutrition and Cancer, 38(2), 158-162. doi: 10.1207/S15327914NC382_3