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JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION & RESEARCH, PUDUCHERRY-605006 (Institute of National Importance under Govt. of India) Ref No: JIP/Res/JSAC 12/2014 Date 12/04/2014

MINUTES OF THE TWELFTH MEETING OF JIPMER SCIENTIFIC ADVISORY COMMITTEE, HELD ON 09-04-2014 in the Seminar Room, Physiology

Department, JIPMER ACADEMIC CENTER ,PUDUCHERRY

The Twelfth Meeting of the JIPMER Scientific Advisory Committee was held on 09-04-2014 in the Seminar Room, Physiology Department, JIPMER

ACADEMIC CENTER under the Chairmanship of the Dean-Research, JIPMER. The following members of the JIPMER Scientific Advisory Committee

were present.

1 .Dr. S.C. Parija, Dean (Research), JIPMER Vice-Chairperson 2. Dr. Santosh Kumar, Professor, Urology, JIPMER Member Secretary 3. Dr. Ajit Sahai, Professor & Head, Biometrics & Member Medical Informatics, JIPMER 4.Dr. Gautam Roy, Professor & Head,Community Medicine, JIPMER Member 5.Dr. D. M. Thappa, Professor, Dermatology & STD, JIPMER Member 6. Dr. R. Raveendran, Professor, Pharmacology, JIPMER Member 7. Dr. G. K. Pal, Professor & Head, Physiology, JIPMER Member 8. Dr. Hannah Rachel Vasanthi, Associate Professor, External Member Biotechnology, Pondicherry University 9. Dr. Jayaprakash Muliyil, Retired Professor, External Member Community Medicine CMC, Vellore 10. Dr.T.K Dutta, Professor & Head , Clinical Hematology Special Invitee At the outset Dr.S.C.Parija, Dean-Research and Vice-Chairman welcomed the members of JSAC. The Minutes of the last meeting of JSAC held on 21.02.2014 were approved. Then the research proposals listed on the agenda were taken up one by one for discussion. After the deliberation, the following decisions were arrived. No. of proposals received-30 No. of proposals discussed-27

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No. of proposals to be resubmitted- 2

No. of proposals approved subject to modifications, if any, and ethical clearance – 25

A) If a research proposal is to be resubmitted, then following must be done.

1. The covering letter must include the JSAC Meeting No. and Serial No. of the proposal and clear mention of addition, deletion or

change carried out as required by the JSAC Minutes.

2. 10 photocopies of the original proposal must be submitted. There must be highlighting of deleted or changed portions in the

photocopies of the original proposal carried out as required by JSAC Minutes.

3. The original copy and 9 photocopies of the revised proposal must be submitted. There must be highlighting of added or changed

portions in the orginal copy and photocopies of revised proposal carried out as required by JSAC Minutes

4. All hard copies must bear JSAC Meeting No. and Serial No. of proposal and Original or Revised on the top margins of front

pages. These hard copies must be submitted to the office of Dean (Research), JIPMER on or before 22-04-2014.

B) If a research proposal is approved subject to modifications, then following must be done.

1. The covering letter must include the JSAC Meeting No. and Serial No. of the proposal and clear mention of addition, deletion or

change carried out as required by the JSAC Minutes.

2. One photocopy of the original proposal must be submitted. There must be highlighting of deleted or changed portions in the

photocopies of the original proposal carried out as required by JSAC Minutes.

3. The original copy of the revised proposal must be submitted. There must be highlighting of added or changed portions in the

original copy of revised proposal carried out as required by JSAC Minutes

4. All hard copies must bear JSAC Meeting No. and Serial No. of proposal and Original or Revised on the top margins of front

pages. These hard copies must be submitted to the office of Dean (Research), JIPMER on or before 22-04-2014.

N.B. 1. The Investigators of the projects will be fully responsible for incorporating the suggested changes in their project proposals.

2. The Investigators of research proposals which were not presented are required to apply afresh in response to next circular of JSAC.

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Sl. No. Names of Investigators and Co-investigators

Titles of the Research Projects Recommendations

1 Investigator: Dr. R. Raveendran, Professor, Pharmacology Co-Investigators: Mr. P. Sagar, Ph. D Scholar, Pharmacology Dr. V. S. Negi, Professor & Head, Clinical Immunology

In vitro cytotoxic effect of cleistanthins A and B on human colorectal cancer stem cells

Not Presented

2 Investigator: Dr. D. G. Shewade, Professor, Pharmacology Co-Investigators: Dr. Biswajit D, Associate Professor, Medical Oncology, Ms. T. Devika, PhD Scholar, Pharmacology

Pharmacogenomics of gemcitabine in patients with metastatic lung cancer

Approved subject to:

naming study design as cohort study with internal comparison

correction of references as per Vancouver style

ethical clearance

3 Investigator: Dr. Steven Aibor Dkhar, Professor, Pharmacology Co-Investigators: Dr. K. Gunaseelan, Associate Professor, Medical Oncology Dr. Kayal Smita, Assistant, Professor, Medical Oncology Mr. Sreenivasulu Palugulla, PhD Scholar, Pharmacology

Oral metronomic therapy and its association with angiogenesis and immunomodulation biomarkers in head and neck cancer: A prospective clinical trial


inclusion of historical controls with same inclusion and exclusion criteria


ethical clearance

4 Investigator: Mr. K. Sreenivasulu, PhD Scholar, Biochemistry Co-Investigators: Dr. H. Nandeesha, Assistant Professor, Biochemistry Dr. Zachariah Bobby, Professor, Biochemistry Dr. L. N. Dorairajan, Professor & Head, Urology

Role of insulin in the pathogenesis of benign prostatic hyperplasia


making guide as PI and PhD scholar as co-investigator

specifying population used for sampling


considering treating study as case control design and calculating relevant odds ratio

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considering random selection of controls

ethical clearance

5 Investigator: Mrs. Raji R, PhD Scholar, Biochemistry Co-Investigators: Dr. R. Soundravally, Associate Professor, Biochemistry Dr. Haritha Sagili, Associate Professor, Obstetrics and Gynaecology Dr. Sivanand Kattimani, Associate Professor, Psychiatry Dr. Nancy Premkumar, Medical Social Worker, JIPMER

Assessment of Vitamin D related gene polymorphisms in postpartum depressio n among Indian women


making guide as PI and PhD scholar as co-investigator

defining cohort

making confounding variables more specific

ethical clearance

6 Investigator: Dr. BH. Srinivas, Assistant Professor, Pathology Co-Investigators: Dr. Priyamvada P S, Assistant Professor, Nephrology Dr. Sreejith Parameswaran, Associate Professor, Nephrology Dr. Bhawana A. Badhe, Professor and Head, Pathology

Utility of C4d immunohistochemistry (IHC) for membranous nephropathy

To be resubmitted with:

proper study design including gold standard for diagnosis

proper format

inclusion of only one co-investigator from Nephrology

7 Investigator: Dr. Jharna Mandal, Associate Professor, Microbiology Co-Investigator:

Dr. Dinoop K P, Senior Resident, Microbiology

To determine the mechanisms of quinolone resistance in Shigella isolates in JIPMER


deletion of “ To determine” from title

replacing “strains” by “isolates”


ethical clearance

8 Investigator: Dr. S. C. Parija, Senior Professor, Microbiology & Dean (Research), JIPMER Co-Investigator: Mr. S. Ajay Philips, PhD Scholar, Microbiology

Genetic diversity and pathogenicity of Entamoeba dispar



ethical clearance

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9 Investigator: Dr. S. C. Parija, Senior Professor, Microbiology & Dean (Research), JIPMER Co-Investigators: Dr. R. P. Swaminathan, Prof. & Head, Medicine Dr. B. Vishnu Bhat, Prof. & Head, Pediatrics Mr. Shashiraja Padukone, PhD Scholar, Microbiology

Prevalence, genetic diversity and pathogenicity study of Blastocystis

in humans



ethical clearance

10 Investigator: Dr. B. N. Harish, Senior Professor & Head, Microbiology Co-Investigator Mr. E. Kalaiarasan, PhD Scholar, Microbiology

Speciation,antimicrobial resistance and virulence factors in clinical isolates of Pseudomonas spp.


naming study design as descriptive



ethical clearance

11 Investigator: Dr. Ambika Prasad Patra, Assistant Professor, Forensic Medicine & Toxicology Co-Investigators: Dr. Kusa Kumar Shaha, Associate Professor, Forensic Medicine & Toxicology Dr. Swaroop Kumar Sahu, Assistant Professor, Preventive and Social Medicine

Analysis of epidemiological factors of unnatural deaths among geriatric population at JIPMER, Pondicherry


defining unnatural death

inclusion of data collection proforma

considering collaborating with other hospitals

ethical clearance

12 Investigator: Dr. S. Mahadevan, Dean and Division Head –Pediatric Critical Care Unit, Pediatrics Co-Investigators: Dr Ramesh Kumar R, Assistant Professor, Pediatrics Dr. Sriram Krishnamurthy, Associate Professor, Pediatrics

Scorpion antivenom and/or prazosin in the management of Mesobuthus 5ephrit scorpion sting envenomation in children: A prospective, randomized, double-blind, placebo-controlled trial

Not presented

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13 Investigator: Dr. Vishnu Bhat, Professor & Head, Pediatrics Co-Investigators: Dr. M. G. Sridhar, Professor & Head , Biochemistry Mrs. N. Banupriya, PhD Scholar, Pediatrics

Role of zinc supplementation on acute inflammatory response and outcome in neonatal sepsis


inclusion of RCT in title

sample size recalculation

calculation of adequacy of blood sample needed for study


specifying a clinician for clinical management

inclusion of commitment for registration of trial

inclusion of reporting adverse events to Data Safety Monitoring Board

ethical clearance

14 Investigator: Dr. Ramesh Kumar R, Assistant Professor, Pediatrics Co-Investigators: Dr. S. Mahadevan, Dean and Division Head –Pediatric Critical Care Unit, Pediatrics Dr. Rajesh Nachiappa Ganesh , Associate Professor, Pathology Dr. Narayanan.P, Associate Professor, Paediatrics

Histopathological changes of septic acute kidney injury in children: A descriptive study of postmortem renal biopsies


inclusion of only one co-investigator from Pediatrics

ethical clearance

15 Investigator: Dr. Narayanan.P, Associate Professor, Paediatrics Co-Investigators: Dr. Ramesh Kumar R, Assistant Professor, Paediatrics Dr. Mahadevan S, Professor, Paediatrics and Dean, JIPMER Dr. Vishnu Bhat, Professor and Head, Paediatrics

Recent Immunization and Survival Effects (RISE) in Pediatric Intensive Care Unit


inclusion of only one co-investigator from Pediatrics

ethical clearance

16 Investigator: Dr. Sriram Krishnamurthy, Associate Professor, Pediatrics Co-Investigators: Dr. Rajesh Nachiappa Ganesh, Associate Professor, Pathology

Percutaneous renal biopsy in children with Nephrotic syndrome: A descriptive study


changing title to “Clinicopathological correlation in children

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Dr. B H Srinivas, Assistant Professor, Pathology Dr. R Srinivasa Raghavan, Senior Resident, Pediatrics

with nephrotic syndrome requiring renal biopsy”

sample size calculation

inclusion of only one co-investigator from Pathology

ethical clearance

17 Investigator: Dr. Krishna Kumar, Assistant Professor Paediatric Surgery Co-Investigators: Dr. Subathra, Assistant Professor, Radiodiagnosis Dr.Madhur K Srivastava, Assistant Professor, Nuclear Medicine Dr.Adarsh, Assistant Professor, Pathology Dr. Kumaravel, Associate Professor, Pediatric Surgery Dr. Bibekanand Jindal, Associate Professor, Pediatric Surgery Dr. Bikash Kumar Naredi, Assistant Professor, Pediatric Surgery

Pilot project on correlation of sonography, nuclear scan, histology with intra op findings in pelvi ureteric junction obstruction in children


inclusion of only one co-investigator from Pediatric Surgery


ethical clearance

18 Investigator: Dr. Pankaj Kundra, Professor and Head, Anesthesiology and Critical Care Co-Investigators: Dr. S. Adinarayanan, Associate Professor , Anesthesiology and Critical Care Dr. Ganesh Kumar, Associate Professor, Preventive and Social Medicine Dr. Praveen Talawar, Assistant Professor, Anaesthesiology and Critical Care

Global burden of Pain survey 2013 Assessment of pain characteristics among more than 18 years of age belonging to LIG (Low income group) in Puducherry and Tamilnadu region.

Not presented

19 Investigator: Dr. Kalaiarasi, Senior resident, ENT Co-Investigator: Dr. Sivaraman, Assistant professor, ENT Dr. Arun Alexander, Associate professor, ENT

Evaluation of causes for the failure of mastoidectomy in chronic otitis media


making a consultant as PI

including only one co-investigator from ENT

inclusion of research

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question

naming study design as descriptive

ethical clearance

20 Investigator: Dr.Sivaraman Ganesan, Assistant Professor, ENT Co-Investigator: Dr. Sithanandakumar@venkatesan, Senior Resident, ENT Dr. Pradipta Kumar Parida, Associate Professor, ENT Dr. Zayapragassarazan Z, Associate Professor, Educational Technology Mr. Harichandrakumar K T, Medical Biometrics and Informatics

Developing and validating script concordance for ENT undergraduate students


inclusion of intra class correlation for test-retest reliability

inclusion of only one co-investigator from ENT

inclusion of all signatures

ethical clearance

21 Investigator: Dr. Sathish A, Senior Resident, ENT Co-Investigator: Dr. Sunil Kumar Saxena, Professor & Head, ENT Dr. Jyotirmay S Hegde, Assistant Professor, ENT Dr.Sivaraman, Assistant Professor, ENT

Assessment of outcomes in revision functional endoscopic sinus surgery in our institute


making a consultant as PI

including only one co-investigator from ENT

specifying research question

naming study design as follow up study


ethical clearance

22 Investigator: Dr. Vikas Menon, Assistant Professor, Psychiatry Co-Investigator:

Mr. K Arivazhagan, Clinical Psychologist cum Tutor,

Psychiatry

Association between metabolic disturbance and cognition in schizophrenia


considering assessment of insulin resistance as a marker


ethical clearance

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23 Investigator: Dr. Gowri Dorairajan, Professor, Obstetrics and Gynaecology Co-Investigator Dr. P. Veena, Associate Professor, Obstetrics and Gynecology

Effect of timing of insertion of puerperal Intrauterine contraceptive device CuT380A on expulsion rates.


changing group 2 as “cases with insertion of IUCD from 10 minutes till 48 hours postpartum”


ethical clearance

24 Investigator: Dr. Nandini Pandit, Additional Professor, Nuclear Medicine Co-Investigators: Dr. Barath Jagadisan, Assistant professor, Pediatric Medicine Dr. Bhawana Badhe, Professor and Head, pathology Dr. Jharna Mandal, Associate Professor, Microbiology Dr Dhanapathi Halanaik, Associate Professor, Nuclear Medicine Dr. Abialbon Paul, Junior Resident, Clinical Pharmacology Ms. E.Ermin Immaculate, Lab Technician, Clinical pharmacology

Diagnostic Power of Carbon 14 Urea Breath Test and Helicobacter Pylori Stool Antigen Test in the Diagnosis of H.Pylori Infection in Pediatric Population


leaving out hypothesis

leaving out Lab Technician as co-investigator

replacing word “power” by “value” in title


ethical clearance

25 Investigator: Dr. Madhur Kumar Srivastava, Assistant Professor, Nuclear Medicine Co-Investigators Dr. Jaya Prakash Sahoo, Assistant Professor, Endocrinology Dr. Dhanapathi Halanaik, Associate Professor, Nuclear Medicine

To see the effect of Lithium in increasing the efficacy of reduced dose of radioiodine (I-131) therapy in hyperthyroid patients – A randomized control Trial.


leaving out “To see” from title

inclusion of randomization with block design

ethical clearance

26 Investigator: Dr. Madhur Kumar Srivastava, Assistant Professor, Nuclear Medicine Co-Investigators: Dr. Sadish Kumar@Kamalnathan, Associate Professor, Endocrinology Dr. Jharna Mandal, Associate Professor, Microbiology Dr. Madhusudhanan Ponnusamy, Assistant Professor,

To see the efficacy of radioiodine (I-131) in eradicating asymptomatic Helicobacter pylori infection in hyperthyroid patients – A pilot study.


leaving out “To see” and “a pilot study” from title

leaving out Lab Technician as co-investigator

leaving out hypothesis

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Nuclear Medicine Dr. Abialbon Paul, Junior Resident, Clinical Pharmacology Ms. E.Ermin Immaculate, Lab Technician, Clinical pharmacology

ethical clearance

27 Investigator: Dr. Dhanapathi Halanaik, Associate Professor, Nuclear Medicine Co-Investigators: Dr. Vikram Kate, Professor, Surgery Dr. Sadish Kamalanathan, Associate Professor, Endocrinology Dr. Biju Pottakat, Associate Professor, Surgical gastroenterology Dr. Biswajit Dubashi, Associate Professor, Medical Oncology Dr. Channaverappa Bammigatti, Associate Professor, Medicine Dr. Madhusudhanan Ponnusamy, Assistant Professor, Nuclear Medicine Dr. Bhawana Badhe, Professor and Head, Pathololgy

Performance measure of 99m Tc- HYNIC TOC (Tyrosine octreotide) scintigraphy in neuroendocrine tumors.

To be resubmitted with:

modification of study design to include a mix of cases with and without disease and a comparison standard

modification of hypothesis and objectives


inclusion of variables to be measured

28 Investigator: Dr. Dinesh Kumar S, Associate Professor, Plastic surgery Co-Investigators: Dr. Devi Prasad Mohapatra, Associate Professor, Plastic Surgery Dr. Friji M T, Associate Professor, Plastic Surgery Dr. Ravi Kumar Chittoria, Additional Professor and Head, Plastic Surgery

Efficacy of using a 3D printing system for fabricating surgical implants – A pilot study


inclusion of only one co-investigator from Plastic Surgery

inclusion of references as per Vancouver style

ethical clearance

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