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Fleischer, Angela; Roller, Alexander; Arion, Vladimir B.; Keppler, Bernhard K.; Mohr, Fabian. Synthesis and structures of palladium(II) and platinum(II) complexes containing heterocyclic thiolate ligands formed by cycloaddition reactions of coordinated azides. Canadian Journal of Chemistry (2009), 87(1), 146-150. Jaschke, Werner; Keppler, Bernhard; Debbage, Paul. Diagnostic imaging in nanomedicine: particles to pharmaceutical nanomedicine. Chimica Oggi (2008), 26(5), 72-79. Renfrew, Anna K.; Phillips, Andrew D.; Egger, Alexander E.; Hartinger, Christian G.; Bosquain, Sylvain S.; Nazarov, Alexey A.; Keppler, Bernhard K.; Gonsalvi, Luca; Peruzzini, Maurizio; Dyson, Paul J. Influence of Structural Variation on the Anticancer Activity of RAPTA-Type Complexes: ptn versus pta. Organometallics, (2009), 28(4), 1165-1172. Novakova, Olga; Nazarov, Alexey A.; Hartinger, Christian G.; Keppler, Bernhard K.; Brabec, Viktor. DNA interactions of dinuclear RuII arene antitumor complexes in cell-free media. Biochemical Pharmacology (2009), 77(3), 364-374. Mendoza-Ferri, Maria G.; Hartinger, Christian G.; Mendoza, Marco A.; Groessl, Michael; Egger, Alexander E.; Eichinger, Rene E.; Mangrum, John B.; Farrell, Nicholas P.; Maruszak, Magdalena; Bednarski, Patrick J.; Klein, Franz; Jakupec, Michael A.; Nazarov, Alexey A.; Severin, Kay; Keppler, Bernhard K.. Transferring the Concept of Multinuclearity to Ruthenium Complexes for Improvement of Anticancer Activity. Journal of Medicinal Chemistry, (2009), 52(4), 916-925. Shaheen, Muhammad Ashraf; Hartinger, Christian G.; Tahir, M. Nawaz; Shafiq, Ahmad Awan; Keppler, Bernhard K.. 5-Hydroxy-2-methyl-4H-pyran-4-one. Acta Crystallographica, Section E: Structure Reports Online (2009), 65(2), o437. Lentz, Frederike; Drescher, Anne; Lindauer, Andreas; Henke, Magdalena; Hilger, Ralf A.; Hartinger, Christian G.; Scheulen, Max E.; Dittrich, Christian; Keppler, Bernhard K.; Jaehde, Ulrich. Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study. Anti-Cancer Drugs (2009), 20(2), 97-103. Kandioller, Wolfgang; Hartinger, Christian G.; Nazarov, Alexey A.; Kasser, Johanna; John, Roland; Jakupec, Michael A.; Arion, Vladimir B.; Dyson, Paul J.; Keppler, Bernhard K..

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Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety. Journal of Organometallic Chemistry (2009), 694(6), 922-929. Grguric-Sipka, Sanja; Stepanenko, Iryna N.; Lazic, Jelena M.; Bartel, Caroline; Jakupec, Michael A.; Arion, Vladimir B.; Keppler, Bernhard K.. Synthesis, x-ray diffraction structure, spectroscopic properties and antiproliferative activity of a novel ruthenium complex with constitutional similarity to cisplatin. Dalton Transactions (2009), (17), 3334-3339. Kasser, Johanna; Nazarov, Alexey A.; Hartinger, Christian G.; Wdziekonski, Brigitte; Dani, Christian; Kuznetsov, Maxim L.; Arion, Vladimir B.; Keppler, Bernhard K.. A one step/one pot synthesis of N,N-bis(phosphonomethyl)amino acids and their effects on adipogenic and osteogenic differentiation of human mesenchymal stem cells. Bioorganic & Medicinal Chemistry (2009), 17(9), 3388-3393. Kandioller, Wolfgang; Hartinger, Christian G.; Nazarov, Alexey A.; Kuznetsov, Maxim L.; John, Roland O.; Bartel, Caroline; Jakupec, Michael A.; Arion, Vladimir B.; Keppler, Bernhard K.. From Pyrone to Thiopyrone Ligands-Rendering Maltol-Derived Ruthenium(II)-Arene Complexes That Are Anticancer Active in Vitro. Organometallics (2009), 28(15), 4249-4251. Kowol, Christian R.; Trondl, Robert; Heffeter, Petra; Arion, Vladimir B.; Jakupec, Michael A.; Roller, Alexander; Galanski, Markus; Berger, Walter; Keppler, Bernhard K.. Impact of Metal Coordination on Cytotoxicity of 3-Aminopyridine-2-carboxaldehyde Thiosemicarbazone (Triapine) and Novel Insights into Terminal Dimethylation. Journal of Medicinal Chemistry (2009), 52(16), 5032-5043. Dyson, Paul J.; Nazarov, Alexey A.; Hartinger, Christian G.; Keppler, Bernhard K.. Design of ruthenium-based small molecules as potential therapeutic agents. Abstracts of Papers, 238th ACS National Meeting, Washington, DC, United States, August 16-20, 2009 (2009), ORGN-593. Apfel, Ulf-Peter; Kowol, Christian R.; Halpin, Yvonne; Kloss, Florian; Kuebel, Joachim; Goerls, Helmar; Vos, Johannes G.; Keppler, Bernhard K.; Morera, Enrico; Lucente, Gino; Weigand, Wolfgang. Investigation of amino acid containing [FeFe] hydrogenase models concerning pendant base effects. Journal of Inorganic Biochemistry (2009), 103(9), 1236-1244. Valiahdi, Seied Mojtaba; Heffeter, Petra; Jakupec, Michael A.; Marculescu, Rodrig; Berger, Walter; Rappersberger, Klemens; Keppler, Bernhard K.. The gallium complex KP46 exerts strong activity against primary explanted melanoma

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cells and induces apoptosis in melanoma cell lines. Melanoma Research (2009), 19(5), 283-293. Biba, Florian; Groessl, Michael; Egger, Alexander; Roller, Alexander; Hartinger, Christian G.; Keppler, Bernhard K.. New Insights into the Chemistry of the Antineoplastic Lanthanum Complex Tris(1,10-phenanthroline)tris(thiocyanato- Biomolecules. European Journal of Inorganic Chemistry (2009), (28), 4282-4287. Mendoza-Ferri, Maria G.; Hartinger, Christian G.; Nazarov, Alexey A.; Eichinger, Rene E.; Jakupec, Michael A.; Severin, Kay; Keppler, Bernhard K.. Influence of the Arene Ligand, the Number and Type of Metal Centers, and the Leaving Group on the in Vitro Antitumor Activity of Polynuclear Organometallic Compounds. Organometallics (2009), 28(21), 6260-6265. Buechel, Gabriel E.; Stepanenko, Iryna N.; Hejl, Michaela; Jakupec, Michael A.; Arion, Vladimir B.; Keppler, Bernhard K.. [OsIVCl5(Hazole)]- Complexes: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity. Inorganic Chemistry (Washington, DC, United States) (2009), 48(22), 10737-10747. Kandioller, Wolfgang; Hartinger, Christian G.; Nazarov, Alexey A.; Bartel, Caroline; Skocic, Matthias; Jakupec, Michael A.; Arion, Vladimir B.; Keppler, Bernhard K.. Maltol-Derived Ruthenium-Cymene Complexes with Tumor Inhibiting Properties: The Impact of Ligand-Metal Bond Stability on Anticancer Activity In Vitro. Chemistry--A European Journal (2009), 15(45), 12283-12291, S12283/1-S12283/32. Schuh, Esther; Valiahdi, Seied M.; Jakupec, Michael A.; Keppler, Bernhard K.; Chiba, Peter; Mohr, Fabian. Synthesis and biological studies of some gold(I) complexes containing functionalised alkynes. Dalton Transactions (2009), (48), 10841-10845. Primik, Michael F.; Muehlgassner, Gerhard; Jakupec, Michael A.; Zava, Olivier; Dyson, Paul J.; Arion, Vladimir B.; Keppler, Bernhard K.. Highly Cytotoxic Copper(II) Complexes with Modified Paullone Ligands. Inorganic Chemistry (Washington, DC, United States) (2010), 49(1), 302-311. Bytzek, Anna K.; Enyedy, Eva A.; Kiss, Tamas; Keppler, Bernhard K.; Hartinger, Christian G. Biodistribution of anti-diabetic Zn(II) complexes in human serum and in vitro protein-binding studies by means of CZE-ICP-MS. Electrophoresis (2009), 30(23), 4075-4082.

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Kowol, Christian R.; Trondl, Robert; Arion, Vladimir B.; Jakupec, Michael A.; Lichtscheidl, Irene; Keppler, Bernhard K.. Fluorescence properties and cellular distribution of the investigational anticancer drug Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(ii) complex. Dalton Transactions (2010), 39(3), 704-706. Biba, Florian; Groessl, Michael; Egger, Alexander; Jakupec, Michael A.; Keppler, Bernhard K.. A Novel Cytotoxic Cerium Complex: Aquatrichloridobis(1,10-phenanthroline)cerium(III) (KP776). Synthesis, Characterization, Behavior in H2O, Binding towards Biomolecules, and Antiproliferative Activity. Chemistry & Biodiversity (2009), 6(12), 2153-2165. Groessl, Michael; Bytzek, Anna; Hartinger, Christian G.. The serum protein binding of pharmacologically active gallium(III) compounds assessed by hyphenated CE-MS techniques. Electrophoresis (2009), 30(15), 2720-2727. Daniel Kogelnig, Anja Stojanovica, Franz Jirsa , Wilfried Korner, Regina Krachler, Bernhard K. Keppler Transport and separation of iron(III) from nickel(II) with the ionic liquid trihexyl(tetradecyl)phosphonium chloride Separation and Purification Technology 72 (2010) 56–60. Stollenwerk, M. M.; Pashkunova-Martic, I.; Kremser, C.; Talasz, H.; Thurner, G. C.; Abdelmoez, A. A.; Wallnoefer, E. A.; Helbok, A.; Neuhauser, E.; Klammsteiner, N.; Klimaschewski, L.; Guggenberg, E.; Froehlich, E.; Keppler, B.; Jaschke, W.; Debbage, P. Albumin-based nanoparticles as magnetic resonance contrast agents. I: Concept, first syntheses and characterization. Histochemistry and Cell Biology (2010), 133(4), 375-404. Stojanovic, Anja; Kogelnig, Daniel; Fischer, Lisa; Hann, Stephan; Galanski, Markus; Groessl, Michael; Krachler, Regina; Keppler, Bernhard K.. Phosphonium and Ammonium Ionic Liquids with Aromatic Anions: Synthesis, Properties, and Platinum Extraction. Australian Journal of Chemistry (2010), 63(3), 511-524. Krachler, Regina; Krachler, Rudolf F.; von der Kammer, Frank; Suephandag, Altan; Jirsa, Franz; Ayromlou, Shahram; Hofmann, Thilo; Keppler, Bernhard K.. Relevance of peat-draining rivers for the riverine input of dissolved iron into the ocean. Science of the Total Environment (2010), 408(11), 2402-2408.

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Djinovic, Vesna M.; Galanski, Markus; Arion, Vladimir B.; Keppler, Bernhard K.. Synthesis and structures of novel 1-methylcytosinato-bridged (ethylenediamine)platinum(ii) and platinum(iii) dinuclear complexes. Dalton Transactions (2010), 39(15), 3633-3643. Bytzek, Anna K.; Reithofer, Michael R.; Galanski, Markus; Groessl, Michael; Keppler, Bernhard K.; Hartinger, Christian G. The first example of MEEKC-ICP-MS coupling and its application for the analysis of anticancer platinum complexes. Electrophoresis (2010), 31(7), 1144-1150. Filak, Lukas K.; Muehlgassner, Gerhard; Jakupec, Michael A.; Heffeter, Petra; Berger, Walter; Arion, Vladimir B.; Keppler, Bernhard K.. Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy. JBIC, Journal of Biological Inorganic Chemistry (2010), 15(6), 903-918. Enyedy, Eva A.; Nagy, Nora V.; Zsigo, Eva; Kowol, Christian R.; Arion, Vladimir B.; Keppler, Bernhard K.; Kiss, Tamas. Comparative Solution Equilibrium Study of the Interactions of Copper(II), Iron(II) and Zinc(II) with Triapine (3-Aminopyridine-2-carbaldehyde Thiosemicarbazone) and Related Ligands. European Journal of Inorganic Chemistry (2010), (11), 1717-1728. Scaffidi-Domianello, Yulia Yu.; Meelich, Kristof; Jakupec, Michael A.; Arion, Vladimir B.; Kukushkin, Vadim Yu.; Galanski, Markus; Keppler, Bernhard K.. Novel Cis- and Trans-Configured Bis(oxime)platinum(II) Complexes: Synthesis, Characterization, and Cytotoxic Activity. Inorganic Chemistry (Washington, DC, United States) (2010), 49(12), 5669-5678. Tamasi, Gabriella; Casolaro, Mario; Magnani, Agnese; Sega, Alessandro; Chiasserini, Luisa; Messori, Luigi; Gabbiani, Chiara; Valiahdi, Seied Mojtaba; Jakupec, Michael A.; Keppler, Bernhard K.; Hursthouse, Michael B.; Cini, Renzo. New platinum-oxicam complexes as anti-cancer drugs. Synthesis, characterization, release studies from smart hydrogels, evaluation of reactivity with selected proteins and cytotoxic activity in vitro. Journal of Inorganic Biochemistry (2010), 04(8), 799-814. Hanif, Muhammad; Nazarov, Alexey A.; Hartinger, Christian G.; Kandioller, Wolfgang; Jakupec, Michael A.; Arion, Vladimir B.; Dyson, Paul J.; Keppler, Bernhard K.. Osmium(ii)-versus ruthenium(ii)-arene carbohydrate-based anticancer compounds: similarities and differences. Dalton Transactions (2010), 39(31), 7345-7352.

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Reithofer, Michael R.; Bytzek, Anna; Valiahdi, Seied M.; Kowol, Christian R.; Groessl, Michael; Galanski, Markus; Hartinger, Christian G.; Jakupec, Michael A.; Keppler, Bernhard K.. Further studies of bis(carboxylato)platinum(IV) compounds: Correlation between, liphoilicity, reduction potential, cellular accumulation and cytotoxicity. Abstracts of Papers, 240th ACS National Meeting, Boston, MA, United States, (2010), INOR-22. Hanif, Muhammad; Henke, Helena; Meier, Samuel M.; Martic, Sanela; Labib, Mahmoud; Kandioller, Wolfgang; Jakupec, Michael A.; Arion, Vladimir B.; Kraatz, Heinz-Bernhard; Keppler, Bernhard K.; Hartinger, Christian G. Is the Reactivity of M(II)-Arene Complexes of 3-Hydroxy-2(1H)-pyridones to Biomolecules the Anticancer Activity Determining Parameter? Inorganic Chemistry (Washington, DC, United States) (2010), 49(17), 7953-7963. Hudej, Rosana; Turel, Iztok; Kanduser, Masa; Scancar, Janez; Kranjc, Simona; Sersa, Gregor; Miklavcic, Damijan; Jakupec, Michael A.; Keppler, Bernhard K.; Cemazar, Maja. The influence of electroporation on cytotoxicity of anticancer ruthenium(III) complex KP1339 in vitro and in vivo. Anticancer Research (2010), 30(6), 2055-2063. Abramkin, Sergey A.; Jungwirth, Ute; Valiahdi, Seied M.; Dworak, Claudia; Habala, Ladislav; Meelich, Kristof; Berger, Walter; Jakupec, Michael A.; Hartinger, Christian G.; Nazarov, Alexey A.; Galanski, Markus; Keppler, Bernhard K.. {(1R,2R,4R)-4-Methyl-1,2-cyclohexanediamine}oxalatoplatinum(II): A Novel Enantiomerically Pure Oxaliplatin Derivative Showing Improved Anticancer Activity in Vivo. Journal of Medicinal Chemistry (2010), 53(20), 7356-7364. Primik, Michael F.; Goschl, Simone; Jakupec, Michael A.; Roller, Alexander; Keppler, Bernhard K.; Arion, Vladimir B. Structure-Activity Relationships of Highly Cytotoxic Copper(II) Complexes with Modified Indolo[3,2-c]quinoline Ligands. Inorganic Chemistry (Washington, DC, United States) (2010), 49(23), 11084-11095. Apfel, Ulf-Peter; Kowol, Christian R.; Morera, Enrico; Goerls, Helmar; Lucente, Gino; Keppler, Bernhard K.; Weigand, Wolfgang. Synthetic and Electrochemical Studies of [2Fe2S] Complexes Containing a 4-Amino-1,2-dithiolane-4-carboxylic Acid Moiety. European Journal of Inorganic Chemistry (2010), (32), 5079-5086. Hanif, Muhammad; Schaaf, Patricia; Kandioller, Wolfgang; Hejl, Michaela; Jakupec, Michael A.; Roller, Alexander; Keppler, Bernhard K.; Hartinger, Christian G. Influence of the Arene Ligand and the Leaving Group on the Anticancer Activity of (Thio)maltol Ruthenium(ii)- -Arene) Complexes.

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Australian Journal of Chemistry (2010), 63(11), 1521-1528. Kogelnig, Daniel; Stojanovic, Anja; von der Kammer, Frank; Terzieff, Peter; Galanski, Markus; Jirsa, Franz; Krachler, Regina; Hofmann, Thilo; Keppler, Bernhard K.. Tetrachloroferrate containing ionic liquids: Magnetic- and aggregation behavior. Inorganic Chemistry Communications (2010), 13(12), 1485-1488. Heffeter, Petra; Boeck, Katharina; Atil, Bihter; Hoda, Mir Ali Reza; Koerner, Wilfried; Bartel, Caroline; Jungwirth, Ute; Keppler, Bernhard K.; Micksche, Michael; Berger, Walter; Koellensperger, Gunda. Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339. JBIC, Journal of Biological Inorganic Chemistry (2010), 15(5), 737-74. Reithofer, Michael R.; Bytzek, Anna K.; Valiahdi, Seied M.; Kowol, Christian R.; Groessl, Michael; Hartinger, Christian G.; Jakupec, Michael A.; Galanski, Markus; Keppler, Bernhard K.. Tuning of lipophilicity and cytotoxic potency by structural variation of anticancer platinum(IV) complexes. Journal of Inorganic Biochemistry (2011), 105(1), 46-51. Filak, Lukas K.; Muehlgassner, Gerhard; Bacher, Felix; Roller, Alexander; Galanski, Markus; Jakupec, Michael A.; Keppler, Bernhard K.; Arion, Vladimir B. Ruthenium- and Osmium-Arene Complexes of 2-Substituted Indolo[3,2-c]quinolines: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity. Organometallics (2011), 30(2), 273-283. Hanif, Muhammad; Meier, Samuel M.; Kandioller, Wolfgang; Bytzek, Anna; Hejl, Michaela; Hartinger, Christian G.; Nazarov, Alexey A.; Arion, Vladimir B.; Jakupec, Michael A.; Dyson, Paul J.; Keppler, Bernhard K.. From hydrolytically labile to hydrolytically stable RuII-arene anticancer complexes with carbohydrate-derived co-ligands. Journal of Inorganic Biochemistry (2011), 105(2), 224-231. Kundu, Amitava; Peterlik, Herwig; Krssak, Martin; Bytzek, Anna K.; Pashkunova-Martic, Irena; Arion, Vladimir B.; Helbich, Thomas H.; Keppler, Bernhard K.. Strategies for the covalent conjugation of a bifunctional chelating agent to albumin: Synthesis and characterization of potential MRI contrast agents. Journal of Inorganic Biochemistry (2011), 105(2), 250-255. Ivanovic, Ivanka; Grguric-Sipka, Sanja; Gligorijevic, Nevenka; Radulovic, Sinisa; Roller, Alexander; Tesic, Zivoslav Lj.; Keppler, Bernhard K.. X-ray structure and cytotoxic activity of a picolinate ruthenium(II)-arene complex. Journal of the Serbian Chemical Society (2011), 76(1), 53-61.

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Apfel, Ulf-Peter; Kowol, Christian R.; Kloss, Florian; Goerls, Helmar; Keppler, Bernhard K.; Weigand, Wolfgang. 0 dithiolanes: Models for the active site of the [FeFe] hydrogenase. Journal of Organometallic Chemistry (2011), 696(5), 1084-1088. Kandioller, Wolfgang; Kurzwernhart, Andrea; Hanif, Muhammad; Meier, Samuel M.; Henke, Helena; Keppler, Bernhard K.; Hartinger, Christian G. Pyrone derivatives and metals: From natural products to metal-based drugs. Journal of Organometallic Chemistry (2011), 696(5), 999-1010. Bippus, Patrick; Skocic, Matthias; Jakupec, Michael A.; Keppler, Bernhard K.; Mohr, Fabian. Synthesis, structures and in vitro cytotoxicity of some cationic cis-platinum(II) complexes containing chelating thiocarbamates. Journal of Inorganic Biochemistry (2011), 105(3), 462-466. Kljun, Jakob; Bytzek, Anna K.; Kandioller, Wolfgang; Bartel, Caroline; Jakupec, Michael A.; Hartinger, Christian G.; Keppler, Bernhard K.; Turel, Iztok. Physicochemical Studies and -p-Cymene Complexes Containing Antibacterial Quinolones. Organometallics (2011), 30(9), 2506-2512. Foteeva, Lidia S.; Trofimov, Denis A.; Kuznetsova, Olga V.; Kowol, Christian R.; Arion, Vladimir B.; 0Keppler, Bernhard K.; Timerbaev, Andrei R. A quantitative structure-activity approach for lipophilicity estimation of antitumor complexes of different metals using microemulsion electrokinetic chromatography. Journal of Pharmaceutical and Biomedical Analysis (2011), 55(3), 409-413. Ungersboeck, Johanna; Philippe, Cecile; Mien, Leonhard-Key; Haeusler, Daniela; Shanab, Karem; Lanzenberger, Rupert; Spreitzer, Helmut; Keppler, Bernhard K.; Dudczak, Robert; Kletter, Kurt; Mitterhauser, Markus; Wadsak, Wolfgang. Microfluidic preparation of [18F]FE@SUPPY and [18F]FE2sUPPY:2 - comparison with conventional radiosyntheses. Nuclear Medicine and Biology (2011), 38(3), 427-434. Buss, Irina; Garmann, Dirk; Galanski, Markus; Weber, Guenther; Kalayda, Ganna V.; Keppler, Bernhard K.; Jaehde, Ulrich. Enhancing lipophilicity as a strategy to overcome resistance against platinum complexes? Journal of Inorganic Biochemistry (2011), 105(5), 709-717. Enyedy, Eva A.; Primik, Michael F.; Kowol, Christian R.; Arion, Vladimir B.; Kiss, Tamas; Keppler, Bernhard K..

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Interaction of Triapine and related thiosemicarbazones with iron(iii)/(ii) and gallium(iii): a comparative solution equilibrium study. Dalton Transactions (2011), 40(22), 5895-5905. Bratsos, Ioannis; Gianferrara, Teresa; Alessio, Enzo; Hartinger, Christian G.; Jakupec, Michael A.; Keppler, Bernhard K.. Ruthenium and other non-platinum anticancer compounds. Bioinorganic Medicinal Chemistry (2011), 151-174. Bartel, Caroline; Egger, Alexander E.; Jakupec, Michael A.; Heffeter, Petra; Galanski, Markus; Berger, Walter; Keppler, Bernhard K.. Influence of ascorbic acid on the activity of the investigational anticancer drug KP1019. JBIC, Journal of Biological Inorganic Chemistry (2011), 16(8), 1205-1215. Enyedy, Eva A.; Horvath, Laszlo; Hetenyi, Anasztazia; Tuccinardi, Tiziano; Hartinger, Christian G.; Keppler, Bernhard K.; Kiss, Tamas. Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies. Bioorganic & Medicinal Chemistry (2011), 19(14), 4202-4210. Büchel, Gabriel E.; Stepanenko, Iryna N.; Hejl, Michaela; Jakupec, Michael A.; Keppler, Bernhard K.; Arion, Vladimir B. En Route to Osmium Analogues of KP1019: Synthesis, Structure, Spectroscopic Properties and Antiproliferative Activity of trans-[OsIVCl4(Hazole)2]. Inorganic Chemistry (Washington, DC, United States) (2011), 50(16), 7690-7697. Kogelnig, Daniel; Regelsberger, Anna; Stojanovic, Anja; Jirsa, Franz; Krachler, Regina; Keppler, Bernhard K.. A polymer inclusion membrane based on the ionic liquid trihexyl(tetradecyl)phosphonium chloride and PVC for solid-liquid extraction of Zn(II) from hydrochloric acid solution. Monatshefte fuer Chemie (2011), 142(8), 769-772. Jungwirth, Ute; Kowol, Christian R.; Keppler, Bernhard K.; Hartinger, Christian G.; Berger, Walter; Heffeter, Petra. Anticancer Activity of Metal Complexes: Involvement of Redox Processes. Antioxidants & Redox Signaling (2011), 15(4), 1085-1127. Fischer, Lisa; Falta, Thomas; Koellensperger, Gunda; Stojanovic, Anja; Kogelnig, Daniel; Galanski, Markus; Krachler, Regina; Keppler, Bernhard K.; Hann, Stephan. Ionic liquids for extraction of metals and metal containing compounds from communal and industrial waste water.

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Water Research (2011), 45(15), 4601-4614. Pichler, Verena; Valiahdi, Seied M.; Jakupec, Michael A.; Arion, Vladimir B.; Galanski, Markus; Keppler, Bernhard K.. Mono-carboxylated diaminedichloridoplatinum(IV) complexes - selective synthesis, characterization, and cytotoxicity. Dalton Transactions (2011), 40(32), 8187-8192. Scaffidi-Domianello, Yulia Yu.; Legin, Anton A.; Jakupec, Michael A.; Arion, Vladimir B.; Kukushkin, Vadim Yu.; Galanski, Markus; Keppler, Bernhard K.. Synthesis, Characterization, and Cytotoxic Activity of Novel Potentially pH-Sensitive Nonclassical Platinum(II) Complexes Featuring 1,3-Dihydroxyacetone Oxime Ligands. Inorganic Chemistry (Washington, DC, United States) (2011), 50(21), 10673-10681. Varbanov, Hristo; Valiahdi, Seied M.; Legin, Anton A.; Jakupec, Michael A.; Roller, Alexander; Galanski, Markus; Keppler, Bernhard K.. Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin. European Journal of Medicinal Chemistry (2011), 46(11), 5456-5464. Stepanenko, Iryna N.; Novak, Maria S.; Muehlgassner, Gerhard; Roller, Alexander; Hejl, Michaela; Arion, Vladimir B.; Jakupec, Michael A.; Keppler, Bernhard K.. Organometallic 3-(1H-Benzimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridines as Potential Anticancer Agents. Inorganic Chemistry (Washington, DC, United States) (2011), 50(22), 11715-11728. Bytzek, Anna K.; Boeck, Katharina; Hermann, Gerrit; Hann, Stephan; Keppler, Bernhard K.; Hartinger, Christian G.; Koellensperger, Gunda. LC- and CZE-ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] (KP1339) in mouse plasma. Metallomics (2011), 3(10), 1049-1055. Zhang, Yun; Kogelnig, Daniel; Morgenbesser, Cornelia; Stojanovic, Anja; Jirsa, Franz; Lichtscheidl-Schultz, Irene; Krachler, Regina; Li, Yanfeng; Keppler, Bernhard K.. Preparation and characterization of immobilized [A336][MTBA] in PVA-alginate gel beads as novel solid-phase extractants for an efficient recovery of Hg (II) from aqueous solutions. Journal of Hazardous Materials (2011), 196 201-209. Meier, Samuel M.; Tsybin, Yury O.; Dyson, Paul J.; Keppler, Bernhard K.; Hartinger, Christian G.

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Fragmentation methods on the balance: unambiguous top-down mass spectrometric characterization of oxaliplatin-ubiquitin binding sites. Analytical and Bioanalytical Chemistry (2012), 402(8), 2655-2662. Stepanenko, Iryna N.; Casini, Angela; Edafe, Fabio; Novak, Maria S.; Arion, Vladimir B.; Dyson, Paul J.; Jakupec, Michael A.; Keppler, Bernhard K. Conjugation of Organoruthenium(II) 3-(1H-Benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and Indolo[3,2-d]benzazepines to Recombinant Human Serum Albumin: a Strategy To Enhance Cytotoxicity in Cancer Cells Inorganic Chemistry (Washington, DC, United States) (2011), 50(24), 12669-12679. Kowol, Christian R.; Heffeter, Petra; Miklos, Walter; Gille, Lars; Trondl, Robert; Cappellacci, Loredana; Berger, Walter; Keppler, Bernhard K. Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds JBIC, Journal of Biological Inorganic Chemistry (2012), 17(3), 409-423. Bartel, Caroline; Bytzek, Anna K.; Scaffidi-Domianello, Yulia Yu.; Grabmann, Gerlinde; Jakupec, Michael A.; Hartinger, Christian G.; Galanski, Markus; Keppler, Bernhard K. Cellular accumulation and DNA interaction studies of cytotoxic trans-platinum anticancer compounds JBIC, Journal of Biological Inorganic Chemistry (2012), 17(3), 465-474. Hanif, Muhammad; Nazarov, Alexey A.; Legin, Anton; Groessl, Michael; Arion, Vladimir B.; Jakupec, Michael A.; Tsybin, Yury O.; Dyson, Paul J.; Keppler, Bernhard K.; Hartinger, Christian G. Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules Chemical Communications (Cambridge, United Kingdom) (2012), 48(10), 1475-1477. Stojanovic, Anja; Keppler, Bernhard K. Ionic Liquids as Extracting Agents for Heavy Metals Separation Science and Technology (2012), 47(2), 189-203. Jungwirth, Ute; Xanthos, Dimitris N.; Gojo, Johannes; Bytzek, Anna K.; Körner, Wilfried; Heffeter, Petra; Abramkin, Sergey A. ; Jakupec, Michael A.; Hartinger, Christian G.; Windberger, Ursula; Galanski, Markus; Keppler, Bernhard K.; Berger, Walter Anticancer activity of methyl-substituted oxaliplatin analogues Molecular Pharmacology (2012), 81(5), 719-728. Meier, Samuel M.; Tsybin, Yury O.; Dyson, Paul J.; Keppler, Bernhard K.; Hartinger, Christian G. Fragmentation methods on the balance: unambiguous top-down mass spectrometric

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characterization of oxaliplatin-ubiquitin binding sites Analytical and Bioanalytical Chemistry (2012), 402(8), 2655-2662. Abramkin, Sergey; Valiahdi, Seied M.; Jakupec, Michael A.; Galanski, Markus; Metzler-Nolte, Nils; Keppler, Bernhard K. Solid-phase synthesis of oxaliplatin-TAT peptide bioconjugates Dalton Transactions (2012), 41(10), 3001-3005. Ginzinger, Werner; Muehlgassner, Gerhard; Arion, Vladimir B.; Jakupec, Michael A.; Roller, Alexander; Galanski, Markus; Reithofer, Michael; Berger, Walter; Keppler, Bernhard K. A SAR study of novel antiproliferative ruthenium and osmium complexes with quinoxalinone ligands in human cancer cell lines Journal of Medicinal Chemistry (2012), 55(7), 3398-3413. Kandioller, Wolfgang; Hanif, Muhammad; Kurzwernhart, Andrea; Meier, Samuel; Barasits, Martina; Keppler, Bernhard; Hartinger, Christian G. (Thio)pyr(id)one derivatives in anticancer research: From natural products to metal-based drugs Abstracts of Papers, 243rd ACS National Meeting & Exposition, San Diego, CA, United States, March 25-March 29, 2012 (2012), INOR-507. Meier, Samuel M.; Hanif, Muhammad; Kandioller, Wolfgang; Keppler, Bernhard K.; Hartinger, Christian G. Biomolecule binding vs. anticancer activity: Reactions of Ru(arene)[(thio)pyr-(id)one] compounds with amino acids and proteins Journal of Inorganic Biochemistry (2012), 108(1), 91-95. Kratz, Felix; Senter, Peter; Steinhagen, Henning; Galanski, Markus; Keppler, Bernhard K. Tumor-targeting strategies with anticancer platinum complexes Drug Delivery in Oncology (2012), 3, 1605-1629. Rohr-Udilova, Nataliya; Sieghart, Wolfgang; Eferl, Robert; Stoiber, Dagmar; Bjoerkhem-Bergman, Linda; Eriksson, Lennart C.; Stolze, Klaus; Hayden, Hubert; Keppler, Bernhard; Sagmeister, Sandra; et al Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma Hepatology (Hoboken, NJ, United States) (2012), 55(4), 1112-1121. Buss, Irina; Kalayda, Ganna V.; Lindauer, Andreas; Reithofer, Michael R.; Galanski, Markus; Keppler, Bernhard K.; Jaehde, Ulrich Effect of reactivity on cellular accumulation and cytotoxicity of oxaliplatin analogues JBIC, Journal of Biological Inorganic Chemistry (2012), 17(5), 699-708.

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Heffeter, Petra; Pirker, Christine; Kowol, Christian R.; Herrman, Gerrit; Dornetshuber, Rita; Miklos, Walter; Jungwirth, Ute; Koellensperger, Gunda; Keppler, Bernhard K.; Berger, Walter Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones Biochemical Pharmacology (2012), 83(12), 1623-1633. Kurzwernhart, Andrea; Kandioller, Wolfgang; Bartel, Caroline; Baechler, Simone; Trondl, Robert; Muehlgassner, Gerhard; Jakupec, Michael A.; Arion, Vladimir B.; Marko, Doris; Keppler, Bernhard K.; et al Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder Chemical Communications (Cambridge, United Kingdom) (2012), 48(40), 4839-4841. Groessl, Michael; Keppler, Bernhard Bioanalysis Young Investigator: Michael Groessl Bioanalysis (2012), 4(8), 873-874. Brandt, Oliver; Mildner, Michael; Egger, Alexander E.; Groessl, Michael; Rix, Uwe; Posch, Martin; Keppler, Bernhard K.; Strupp, Christian; Mueller, Beat; Stingl, Georg Nanoscalic silver possesses broad-spectrum antimicrobial activities and exhibits fewer toxicological side effects than silver sulfadiazine Nanomedicine (New York, NY, United States) (2012), 8(4), 478-488. Gogna, Rajan; Madan, Esha; Keppler, Bernhard; Pati, Uttam Gallium compound GaQ3-induced Ca2+ signalling triggers p53-dependent and -independent apoptosis in cancer cells British Journal of Pharmacology (2012), 166(2), 617-636. Jungwirth, Ute; Xanthos, Dimitris N.; Gojo, Johannes; Bytzek, Anna K.; Koerner, Wilfried; Heffeter, Petra; Abramkin, Sergey A.; Jakupec, Michael A.; Hartinger, Christian G.; Windberger, Ursula; et al Anticancer activity of methyl-substituted oxaliplatin analogs Molecular Pharmacology (2012), 81(5), 719-728. Hummer, Alfred A.; Bartel, Caroline; Arion, Vladimir B.; Jakupec, Michael A.; Meyer-Klaucke, Wolfram; Geraki, Tina; Quinn, Paul D.; Mijovilovich, Ana; Keppler, Bernhard K.; Rompel, Annette X-ray Absorption Spectroscopy of an Investigational Anticancer Gallium(III) Drug: Interaction with Serum Proteins, Elemental Distribution Pattern, and Coordination of the Compound in Tissue Journal of Medicinal Chemistry (2012), 55(11), 5601-5613.

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Habala, Ladislav.; Bartel, Caroline.; Giester, Gerald.; Ionita, G.; Jakupec, Michael.; Valentova, J.; Keppler, Bernhard. K.; Rompel, Annette.; Devinsky, F. Preparation, characterization, and bioactivity of a novel oxovanadium complex From Monograph Series of the International Conferences on Coordination and Bioinorganic Chemistry held periodically at Smolenice in Slovakia (2011), 10(New Trends in Coordination, Bioinorganic, and Applied Inorganic Chemistry), 124-132. Scaffidi-Domianello, Yulia Yu.; Legin, Anton A.; Jakupec, Michael A.; Roller, Alexander; Kukushkin, Vadim Yu.; Galanski, Markus; Keppler, Bernhard K. Novel Oximato-Bridged Platinum(II) Di- and Trimer(s): Synthetic, Structural, and in Vitro Anticancer Activity Studies Inorganic Chemistry (Washington, DC, United States) (2012), 51(13), 7153-7163. Fuerhacker, Maria; Haile, Tadele Measho; Kogelnig, Daniel; Stojanovic, Anja; Keppler, Bernhard Application of ionic liquids for the removal of heavy metals from wastewater and activated sludge Water Science and Technology (2012), 65(10), 1765-1773. Buechel, Gabriel E.; Stepanenko, Iryna N.; Hejl, Michaela; Jakupec, Michael A.; Keppler, Bernhard K.; Heffeter, Petra; Berger, Walter; Arion, Vladimir B. Osmium(IV) complexes with 1H- and 2H-indazoles: Tautomer identity versus spectroscopic properties and antiproliferative activity Journal of Inorganic Biochemistry (2012), 113, 47-54. Hudej, Rosana; Kljun, Jakob; Kandioller, Wolfgang; Repnik, Urska; Turk, Boris; Hartinger, Christian G.; Keppler, Bernhard K.; Miklavcic, Damijan; Turel, Iztok Synthesis and Biological Evaluation of the Thionated Antibacterial Agent Nalidixic Acid and Its Organoruthenium(II) Complex Organometallics, (2012), 31(16), 5867-5874. Enyedy, Eva A.; Zsigo, Eva; Nagy, Nora V.; Kowol, Christian R.; Roller, Alexander; Keppler, Bernhard K.; Kiss, Tamas Complex-Formation Ability of Salicylaldehyde Thiosemicarbazone towards ZnII, CuII, FeII, FeIII and GaIII Ions European Journal of Inorganic Chemistry, (2012), 2012(25), 4036-4047, S4036/1-S4036/5. Arion, Vladimir B.; Dobrov, Anatolie; Goeschl, Simone; Jakupec, Michael A.; Keppler, Bernhard K.; Rapta, Peter Ruthenium- and osmium-arene-based paullones bearing a TEMPO free-radical unit as potential anticancer drugs Chemical Communications , (Cambridge, United Kingdom(2012), 48(68), 8559-8561

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Gavrish, Sergey P.; Lampeka, Yaroslaw D.; Lightfoot, Philip; Arion, Vladimir B.; Keppler, Bernhard K.; Wozniak, Krzysztof Solid State Structural Variations in Copper(II) Complexes of Open-Chain and Macrocyclic Malonamide-Derived Ligan Crystal Growth & Design, (2012), 12(9), 4388-4396. Milunovic, Miljan N. M.; Enyedy, Eva A.; Nagy, Nora V.; Kiss, Tamas; Trondl, Robert; Jakupec, Michael A.; Keppler, Bernhard K.; Krachler, Regina; Novitchi, Ghenadie; Arion, Vladimir B. L- and D-Proline Thiosemicarbazone Conjugates: Coordination Behavior in Solution and the Effect of Copper(II) Coordination on Their Antiproliferative Activity Inorganic Chemistry (Washington, DC, United States), (2012), 51(17), 9309-9321. Hoffmeister, Bjoern R.; Adib-Razavi, Mahsa S.; Jakupec, Michael A.; Galanski, Markus; Keppler, Bernhard K. Diamminetetrakis(carboxylato)platinum(IV) Complexes - Synthesis, Characterization, and Cytotoxicity Chemistry & Biodiversity (2012), 9(9), 1840-1848. Henke, Helena; Kandioller, Wolfgang; Hanif, Muhammad; Keppler, Bernhard K.; Hartinger, Christian G. Organometallic Ruthenium and Osmium Compounds of Pyridin-2- and -4-ones as Potential Anticancer Agents Chemistry & Biodiversity (2012), 9(9), 1718-1727. Kupcewicz, Bogumila; Sobiesiak, Krzysztof; Malinowska, Katarzyna; Koprowska, Kamila; Czyz, Malgorzata; Keppler, Bernhard; Budzisz, Elzbieta Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics Medicinal Chemistry Research (2013), 22(5), 2395-2402. Krachler, Regina; von der Kammer, Frank; Jirsa, Franz; Suephandag, Altan; Krachler, Rudolf F.; Plessl, Christof; Vogt, Margret; Keppler, Bernhard K.; Hofmann, Thilo Nanoscale lignin particles as sources of dissolved iron to the ocean Global Biogeochemical Cycles (2012), 26(Sept.), GB3024/1-GB3024/9. Doemoetoer, Orsolya; Hartinger, Christian G.; Bytzek, Anna K.; Kiss, Tamas; Keppler, Bernhard K.; Enyedy, Eva A. Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies Journal of Biological Inorganic Chemistry (2013), 18(1), 9-17. Ginzinger, Werner; Egger, Alexander; Muehlgassner, Gerhard; Arion, Vladimir B.; Jakupec,

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Michael A.; Galanski, Markus; Berger, Walter; Keppler, Bernhard K. Water-Soluble Cationic Derivatives of Indirubin, the Active Anticancer Component from Indigo naturalis Chemistry & Biodiversity (2012), 9(10), 2175-2185. Muehlgassner, Gerhard; Bartel, Caroline; Schmid, Wolfgang F.; Jakupec, Michael A.; Arion, Vladimir B.; Keppler, Bernhard K. Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells Journal of Inorganic Biochemistry (2012), 116, 180-187. Stojanovic, Anja; Morgenbesser, Cornelia; Kogelnig, Daniel; Krachler, Regina; Keppler, Bernhard K. Quaternary ammonium and phosphonium ionic liquids in chemical and environmental engineering Ionic Liquids: Theory, Properties, New Approaches (2011), 657-680. Kurzwernhart, Andrea; Kandioller, Wolfgang; Bachler, Simone; Bartel, Caroline; Martic, Sanela; Maruszak, Magdalena; Muehlgassner, Gerhard; Jakupec, Michael A.; Kraatz, Heinz-Bernhard; Bednarski, Patrick J.;Arion,Vladimir; Marko,Doris; Keppler,Bernhard; Hartinger,Christian Structure-activity relationships of targeted RuII(η6-p-cymene) anticancer complexes with flavonol-derived ligands Journal of Medicinal Chemistry (2012), 55(23), 10512-10522. Enyedy, Eva A.; Domotor, Orsolya; Varga, Erika; Kiss, Tamas; Trondl, Robert; Hartinger, Christian G.; Keppler, Bernhard K. Comparative solution equilibrium studies of anticancer gallium(III) complexes of 8-hydroxyquinoline and hydroxy(thio)pyrone ligands Journal of Inorganic Biochemistry (2012), 117, 189-197. Grabmann, Gerlinde; Meier, Samuel M.; Scaffidi-Domianello, Yulia Y.; Galanski, Markus; Keppler, Bernhard K.; Hartinger, Christian G. Capillary zone electrophoresis and capillary zone electrophoresis-electrospray ionization mass spectrometry studies on the behavior of anticancer cis- and trans-[dihalidobis(2-propanone oxime)platinum(II)] complexes in aqueous solutions Journal of Chromatography, A (2012), 1267, 156-161. Pichler, Verena; Heffeter, Petra; Valiahdi, Seied M.; Kowol, Christian R.; Egger, Alexander; Berger, Walter; Jakupec, Michael A.; Galanski, Markus; Keppler, Bernhard K. Unsymmetric Mono- and Dinuclear Platinum(IV) Complexes Featuring an Ethylene Glycol Moiety: Synthesis, Characterization, and Biological Activity Journal of Medicinal Chemistry (2012), 55(24), 11052-11061.

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Varbanov, Hristo P.; Valiahdi, Seied M.; Kowol, Christian R.; Jakupec, Michael A.; Galanski, Markus; Keppler, Bernhard K. Novel tetracarboxylatoplatinum(IV) complexes as carboplatin prodrugs Dalton Transactions (2012), 41(47), 14404-14415. Varbanov, Hristo P.; Jakupec, Michael A.; Roller, Alexander; Jensen, Frank; Galanski, Markus; Keppler, Bernhard K. Theoretical Investigations and Density Functional Theory Based Quantitative Structure-Activity Relationships Model for Novel Cytotoxic Platinum(IV) Complexes Journal of Medicinal Chemistry (2013), 56(1), 330-344. Hummer, Alfred A.; Heffeter, Petra; Berger, Walter; Filipits, Martin; Batchelor, David; Buechel, Gabriel E.; Jakupec, Michael A.; Keppler, Bernhard K.; Rompel, Annette X-ray Absorption Near Edge Structure Spectroscopy to Resolve the in Vivo Chemistry of the Redox-Active Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Journal of Medicinal Chemistry (2013), 56(3), 1182-1196. Filak, Lukas K.; Goeschl, Simone; Heffeter, Petra; Ghannadzadeh Samper, Katia; Egger, Alexander E.; Jakupec, Michael A.; Keppler, Bernhard K.; Berger, Walter; Arion, Vladimir B. Metal-Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs. Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation Organometallics (2013), 32(3), 903-914. Babak, Maria V.; Meier, Samuel M.; Legin, Anton A.; Adib Razavi, Mahsa S.; Roller, Alexander; Jakupec, Michael A.; Keppler, Bernhard K.; Hartinger, Christian G. Am(m)ines Make the Difference: Organoruthenium Am(m)ine Complexes and Their Chemistry in Anticancer Drug Development Chemistry - A European Journal (2013), 19(13), 4308-4318. Valiahdi, Seied Mojtaba; Egger, Alexander E.; Miklos, Walter; Jungwirth, Ute; Meelich, Kristof; Nock, Petra; Berger, Walter; Hartinger, Christian G.; Galanski, Markus; Jakupec, Michael A.; et al Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexes JBIC, Journal of Biological Inorganic Chemistry (2013), 18(2), 249-260 Pichler, Verena; Mayr, Josef; Heffeter, Petra; Doemoetoer, Orsolya; Enyedy, Eva A.; Hermann, Gerrit; Groza, Diana; Koellensperger, Gunda; Galanksi, Markus; Berger, Walter; et al Maleimide-functionalised platinum(iv) complexes as a synthetic platform for targeted drug delivery Chemical Communications (Cambridge, United Kingdom) (2013), 49(22), 2249-2251.

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Muhammad Hanif, Samuel M Meier, Alexey A Nazarov, Julie Risse, Anton Legin, Angela Casini, Michael A Jakupec, Bernhard K Keppler, Christian G Hartinger Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes. Frontiers in Chemistry 01/2013; 1:27. Jirsa, Franz; Neubauer, Elisabeth; Kittinger, Richard; Hofmann, Thilo; Krachler, Regina; von der Kammer, Frank; Keppler, Bernhard K. Natural organic matter and iron export from the Tanner Moor, Austria Limnologica (2013), 43(4), 239-244. Meier, Samuel M.; Hanif, Muhammad; Adhireksan, Zenita; Pichler, Verena; Novak, Maria; Jirkovsky, Elisabeth; Jakupec, Michael A.; Arion, Vladimir B.; Davey, Curt A.; Keppler, Bernhard K.; et al Novel metal(ii) arene 2-pyridinecarbothioamides: a rationale to orally active organometallic anticancer agents Chemical Science (2013), 4(4), 1837-1846. Kandioller, Wolfgang; Balsano, Evelyn; Meier, Samuel M.; Jungwirth, Ute; Goeschl, Simone; Roller, Alexander; Jakupec, Michael A.; Berger, Walter; Keppler, Bernhard K.; Hartinger, Christian G. Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity Chemical Communications (Cambridge, United Kingdom) (2013), 49(32), 3348-3350. Kurzwernhart, Andrea; Kandioller, Wolfgang; Enyedy, Eva A.; Novak, Maria; Jakupec, Michael A.; Keppler, Bernhard K.; Hartinger, Christian G. 3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure-activity relationships and stability studies on RuII(arene) anticancer complexes with biologically active ligands Dalton Transactions (2013), 42(17), 6193-6202. Banfic, Jelena; Adib-Razavi, Mahsa S.; Galanski, Markus; Keppler, Bernhard K. Platinum(IV) Complexes Featuring Axial (1, 4-13C2)Succinato Ligands - Synthesis, Characterization, and Preliminary -Investigations in Cancer Cell Lysates Zeitschrift für Anorganische und Allgemeine Chemie (2013), 639(8-9), 1613-1620. Grabmann, Gerlinde; Keppler, Bernhard K.; Hartinger, Christian G. A systematic capillary electrophoresis study on the effect of the buffer composition on the reactivity of the anticancer drug cisplatin to the DNA model 2'-deoxyguanosine 5'-monophosphate (dGMP) Analytical and Bioanalytical Chemistry (2013), 405(20), 6417-6424.

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Schwarz, Martina B.; Kurzwernhart, Andrea; Roller, Alexander; Kandioller, Wolfgang; Keppler, Bernhard K.; Hartinger, Christian G. Rhodium(Cp*) Compounds with Flavone-derived Ligand Systems: Synthesis and Characterization Zeitschrift für Anorganische und Allgemeine Chemie (2013), 639(8-9), 1648-1654. Meier, Samuel M.; Novak, Maria; Kandioller, Wolfgang; Jakupec, Michael A.; Arion, Vladimir B.; Metzler-Nolte, Nils; Keppler, Bernhard K.; Hartinger, Christian G. Identification of the Structural Determinants for Anticancer Activity of a Ruthenium Arene Peptide Conjugate

Chemistry - A European Journal, (2013), 19(28), 9297-9307. Enyedy, Eva A.; Sija, Eva; Jakusch, Tamas; Hartinger, Christian G.; Kandioller, Wolfgang; Keppler, Bernhard K.; Kiss, Tamas Solution equilibria of anticancer ruthenium(II)-(η6-p-cymene)-hydroxy(thio)pyr(id)one complexes: Impact of sulfur vs. oxygen donor systems on the speciation and bioactivity Journal of Inorganic Biochemistry ( 2013), 127, 161-168. Heffeter, Petra; Atil, Bihter; Kryeziu, Kushtrim; Groza, Diana; Koellensperger, Gunda; Koerner, Wilfried; Jungwirth, Ute; Mohr, Thomas; Keppler, Bernhard K.; Berger, Walter The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo European Journal of Cancer (2013), 49(15), 3366-3375. Pichler, Verena; Goeschl, Simone; Meier, Samuel M.; Roller, Alexander; Jakupec, Michael A.; Galanski, Markus; Keppler, Bernhard K. Bulky N(,N)-(Di)alkylethane-1,2-diamineplatinum(II) Compounds as Precursors for Generating Unsymmetrically Substituted Platinum(IV) Complexes Inorganic Chemistry (2013), 52(14), 8151-8162. Ivanovic, Ivanka; Gligorijevic, Nevenka; Arandjelovic, Sandra; Radulovic, Sinisa; Roller, Alexander; Keppler, Bernhard K.; Tesic, Zivoslav Lj.; Grguric-Sipka, Sanja New ruthenium(II)-arene complexes bearing hydrazides and the corresponding (thio)semicarbazones of 3- and 4-acetylpyridine: Synthesis, characterization, crystal structure determination and antiproliferative activity Polyhedron (2013), 61, 112-118. Madan, Esha; Gogna, Rajan; Keppler, Bernhard; Pati, Uttam P53 increases intra-cellular calcium release by transcriptional regulation of calcium channel TRPC6 in GaQ3-treated cancer cells PLoS One (2013), 8(8), e71016.

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Banfic, Jelena; Legin, Anton A.; Jakupec, Michael A.; Galanski, Markus; Keppler, Bernhard K. Platinum(IV) Complexes Featuring One or Two Axial Ferrocene Bearing Ligands - Synthesis, Characterization, and Cytotoxicity European Journal of Inorganic Chemistry (2014), 2014(3), 484-492. Fischer, Britta; Heffeter, Petra; Kryeziu, Kushtrim; Gille, Lars; Meier, Samuel M.; Berger, Walter; Kowol, Christian R.; Keppler, Bernhard K. Poly(lactic acid) nanoparticles of the lead anticancer ruthenium compound KP1019 and its surfactant-mediated activation Dalton Transactions (2014), 43(3), 1096-1104. Sija, Eva; Hartinger, Christian G.; Keppler, Bernhard K.; Kiss, Tamas; Enyedy, Eva A. Solution equilibrium studies of anticancer ruthenium(II)-η6-p-cymene complexes of pyridinecarboxylic acids Polyhedron (2014), 67, 51-58. Legin, Anton A.; Jakupec, Michael A.; Bokach, Nadezhda A.; Tyan, Marina R.; Kukushkin, Vadim Yu.; Keppler, Bernhard K. Guanidine platinum(II) complexes: synthesis, in vitro antitumor activity, and DNA interactions Journal of Inorganic Biochemistry (2014), 133, 33-39. Domotor, Orsolya; Aicher, Sabine; Schmidlehner, Melanie; Novak, Maria S.; Roller, Alexander; Jakupec, Michael A.; Kandioller, Wolfgang; Hartinger, Christian G.; Keppler, Bernhard K.; Enyedy, Eva A. Antitumor pentamethylcyclopentadienyl rhodium complexes of maltol and allomaltol: Synthesis, solution speciation and bioactivity Journal of Inorganic Biochemistry (2014), 134, 57-65. Heffeter, P.; Riabtseva, A.; Senkiv, Y.; Kowol, C. R.; Koerner, W.; Jungwith, U.; Mitina, N.; Keppler, B. K.; Konstantinova, T.; Yanchuk, I.; et al Nanoformulation improves activity of the (pre)clinical anticancer ruthenium complex KP1019 Journal of Biomedical Nanotechnology (2014), 10(5), 877-884. Trondl, Robert; Flocke, Lea S.; Kowol, Christian R.; Heffeter, Petra; Jungwirth, Ute; Mair, Georg E.; Steinborn, Ralf; Enyedy, Eva A.; Jakupec, Michael A.; Berger, Walter; et al Triapine and a more potent dimethyl derivative induce endoplasmic reticulum stress in cancer cells Molecular Pharmacology (2014), 85(3), 451-459, 11 pp. Matczuk, Magdalena; Foteeva, Lidia S.; Jarosz, Maciej; Galanski, Markus; Keppler, Bernhard K.; Hirokawa, Takeshi; Timerbaev, Andrei R

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Can neutral analytes be concentrated by transient isotachophoresis in micellar electrokinetic chromatography and how much? Journal of Chromatography A (2014), 1345, 212-218. Ossipov, Konstantin; Scaffidi-Domianello, Yulia Y.; Seregina, Irina F.; Galanski, Markus; Keppler, Bernhard K.; Timerbaev, Andrei R.; Bolshov, Mikhail A. Inductively coupled plasma mass spectrometry for metallodrug development: Albumin binding and serum distribution of cytotoxic cis- and trans-isomeric platinum(II) complexes Journal of Inorganic Biochemistry (2014), 137, 40-45. Meier, Samuel M.; Novak, Maria S.; Kandioller, Wolfgang; Jakupec, Michael A.; Roller, Alexander; Keppler, Bernhard K.; Hartinger, Christian G. Aqueous chemistry and antiproliferative activity of a pyrone-based phosphoramidate Ru(arene) anticancer agent Dalton Transactions (2014), 43(26), 9851-9855. Trondl, Robert; Heffeter, Petra; Kowol, Christian R.; Jakupec, Michael A.; Berger, Walter; Keppler, Bernhard K. NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application Chemical Science (2014), 5(8), 2925-2932. Legin, Anton A.; Schintlmeister, Arno; Jakupec, Michael A.; Galanski, Markus; Lichtscheidl, Irene; Wagner, Michael; Keppler, Bernhard K. NanoSIMS combined with fluorescence microscopy as a tool for subcellular imaging of isotopically labeled platinum-based anticancer drugs Chemical Science (2014), 5(8), 3135-3143. Varbanov, Hristo P.; Goeschl, Simone; Heffeter, Petra; Theiner, Sarah; Roller, Alexander; Jensen, Frank; Jakupec, Michael A.; Berger, Walter; Galanski, Markus; Keppler, Bernhard K. A Novel Class of Bis- and Tris-Chelate Diam(m)inebis(dicarboxylato)platinum(IV) Complexes as Potential Anticancer Prodrugs Journal of Medicinal Chemistry (2014), 57(15), 6751-6764. Hanif, Muhammad; Nawaz, Muhammad Azhar Hayat; Babak, Maria V.; Iqbal, Jamshed; Roller, Alexander; Keppler, Bernhard K.; Hartinger, Christian G. RutheniumII (η6-arene) complexes of thiourea derivatives: synthesis, characterization and urease inhibition Molecules (2014), 19(6), 8080-8092, 13 pp. Tamasi, Gabriella; Carpini, Alice; Valensin, Daniela; Messori, Luigi; Pratesi, Alessandro; Scaletti, Federica; Jakupec, Michael; Keppler, Bernhard; Cini, Renzo {Ru(CO)x}-core complexes with selected azoles: Synthesis, X-ray structure,

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spectroscopy, DFT analysis and evaluation of cytotoxic activity against human cancer cells Polyhedron (2014), 81, 227-237. Egger, Alexander E.; Theiner, Sarah; Kornauth, Christoph; Heffeter, Petra; Berger, Walter; Keppler, Bernhard K.; Hartinger, Christian G. Quantitative bioimaging by LA-ICP-MS: a methodological study on the distribution of Pt and Ru in viscera originating from cisplatin- and KP1339-treated mice Metallomics (2014), 6(9), 1616-1625. Jirsa, Franz; Pirker, Daniel; Krachler, Regina; Keppler, Bernhard K. Total Mercury in Sediments, Macrophytes, and Fish from a Shallow Steppe Lake in Eastern Austria Chemistry & Biodiversity (2014), 11(8), 1263-1275. Schmidlehner, Melanie; Kuhn, Paul-Steffen; Hackl, Carmen M.; Roller, Alexander; Kandioller, Wolfgang; Keppler, Bernhard K. Microwave-assisted synthesis of N-heterocycle-based organometallics Journal of Organometallic Chemistry (2014), 772-773, 93-99. Jungwirth, Ute; Gojo, Johannes; Tuder, Theresa; Walko, Gernot; Holcmann, Martin; Schoefl, Thomas; Nowikovsky, Karin; Wilfinger, Nastasia; Schoonhoven, Sushilla; Kowol, Christian R.; Lemmens-Gruber R; Heffeter P; Keppler BK; Berger W. Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Molecular Cancer Therapeutics (2014), 13(10), 2436-2449. Hudej, Rosana; Miklavcic, Damijan; Cemazar, Maja; Todorovic, Vesna; Sersa, Gregor; Bergamo, Alberta; Sava, Gianni; Martincic, Anze; Scancar, Janez; Keppler, Bernhard K.; et al Modulation of Activity of Known Cytotoxic Ruthenium(III) Compound (KP418) with Hampered Transmembrane Transport in Electrochemotherapy In Vitro and In Vivo Journal of Membrane Biology (2014), 247(12), 1239-1251.

Martincic, Anze; Milacic, Radmila; Vidmar, Janja; Turel, Iztok; Keppler, Bernhard K.; Scancar, Janez New method for the speciation of Ru-based chemotherapeutics in human serum by conjoint liquid chromatography on affinity and anion-exchange monolithic disks Journal of Chromatography A (2014), 1371, 168-176.

Kuhn, P.-S.; Pichler, V.; Roller, A.; Hejl, M.; Jakupec, M. A.; Kandioller, W.; Keppler, B. K. Improved reaction conditions for the synthesis of new NKP-1339 derivatives and preliminary investigations on their anticancer potential Dalton Transactions (2015), 44(2), 659-668.

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Schmidlehner, Melanie; Pichler, Verena; Roller, Alexander; Jakupec, Michael A.; Kandioller, Wolfgang; Keppler, Bernhard K. Organometallic complexes of (thio)allomaltol-based Mannich-products: Synthesis, stability and preliminary biological investigations Journal of Organometallic Chemistry (2015), 782, 69-76. Enyedy, Eva A.; Domotor, Orsolya; Bali, Krisztina; Hetenyi, Anasztazia; Tuccinardi, Tiziano; Keppler, Bernhard K. Interaction of the anticancer gallium(III) complexes of 8-hydroxyquinoline and maltol with human serum proteins JBIC, Journal of Biological Inorganic Chemistry (2015), 20(1), 77-88. Theiner, Sarah; Varbanov, Hristo P.; Galanski, Markus; Egger, Alexander E.; Berger, Walter; Heffeter, Petra; Keppler, Bernhard K. Comparative in vitro and in vivo pharmacological investigation of platinum(IV) complexes as novel anticancer drug candidates for oral application JBIC, Journal of Biological Inorganic Chemistry (2015), 20(1), 89-99. Platzer, Sonja; Sap, Orhan; Leyma, Raphlin; Wallner, Gabriele; Jirsa, Franz; Kandioller, Wolfgang; Krachler, Regina; Keppler, Bernhard K. Extraction of natural radionuclides from aqueous solutions by novel maltolate-based task-specific ionic liquids Journal of Radioanalytical and Nuclear Chemistry (2015), 303(3), 2483-2488. Egger, Alexander E.; Kornauth, Christoph; Haslik, Werner; Hann, Stephan; Theiner, Sarah; Bayer, Guenther; Hartinger, Christian G.; Keppler, Bernhard K.; Pluschnig, Ursula; Mader, Robert M. Extravasation of Pt-based chemotherapeutics - bioimaging of their distribution in resectates using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) Metallomics (2015), 7(3), 508-515. Babak, Maria; Meier, Samuel M.; Huber, Kilian; Reynisson, Johannes; Legin, Anton; Jakupec, Michael; Roller, Alexander; Stukalov, Alexey; Gridling, Manuela; Bennett, Keiryn L.; et al Target Profiling of an Antimetastatic RAPTA Agent by Chemical Proteomics: Relevance to the Mode of Action Chemical Science (2015), 6(4), 2449-2456. Mokesch, Stephan; Novak, Maria S.; Roller, Alexander; Jakupec, Michael A.; Kandioller, Wolfgang; Keppler, Bernhard K. 1,3-Dioxoindane-2-carboxamides as bioactive ligand scaffolds for the development of novel organometallic anticancer drugs

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Organometallics (2015), 34(5), 848-857.

Miklos, W.; Pelivan, K.; Kowol, C. R.; Pirker, C.; Dornetshuber-Fleiss, R.; Spitzwieser, M.; Englinger, B.; van Schoonhoven, S.; Cichna-Markl, M.; Koellensperger, G.; et al Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance Cancer Letters (New York, NY, United States) (2015), 361(1), 112-120. Hoffmeister, Bjoern R.; Hejl, Michaela; Jakupec, Michael A.; Galanski, Markus; Keppler, Bernhard K. Bis- and Tris(carboxylato)platinum(IV) Complexes with Mixed Am(m)ine Ligands in the trans Position Exhibiting Exceptionally High Cytotoxicity European Journal of Inorganic Chemistry (2015), 2015(10), 1700-1708. Theiner, Sarah; Kornauth, Christoph; Varbanov, Hristo P.; Galanski, Markus; Van Schoonhoven, Sushilla; Heffeter, Petra; Berger, Walter; Egger, Alexander E.; Keppler, Bernhard K. Tumor microenvironment in focus: LA-ICP-MS bioimaging of a preclinical tumor model upon treatment with platinum(IV)-based anticancer agents Metallomics (2015),7(8),1256-1264. Enyedy, Eva A.; Domotor, Orsolya; Hackl, Carmen M.; Roller, Alexander; Novak, Maria S.; Jakupec, Michael A.; Keppler, Bernhard K.; Kandioller, Wolfgang Solution equilibria and antitumor activities of pentamethylcyclopentadienyl rhodium complexes of picolinic acid and deferiprone Journal of Coordination Chemistry (2015), 68(9), 1583-1601. Hoffmeister, Bjoern R.; Hejl, Michaela; Adib-Razavi, Mahsa S.; Jakupec, Michael A.; Galanski, Markus; Keppler, Bernhard K. Bis- and Tetrakis(carboxylato)platinum(IV) Complexes with Mixed Axial Ligands - Synthesis, Characterization, and Cytotoxicity Chemistry & Biodiversity (2015), 12(4), 559-574. Habala, Ladislav; Bartel, Caroline; Giester, Gerald; Jakupec, Michael A.; Keppler, Bernhard K.; Rompel, Annette Complexes of N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid with group 12 metals and vanadium-Synthesis, structure and bioactivity of the vanadium complex Journal of Inorganic Biochemistry (2015), 147, 147-152. Babak, Maria V.; Plazuk, Damian; Meier, Samuel M.; Arabshahi, Homayon John; Reynisson, Johannes; Rychlik, Blazej; Blauz, Andrzej; Szulc, Katarzyna; Hanif, Muhammad; Strobl, Sebastian; et al

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Half-Sandwich Ruthenium(II) Biotin Conjugates as Biological Vectors to Cancer Cells Chemistry - A European Journal (2015), 21(13), 5110-5117. Krachler, Regina; Krachler, Rudolf F.; Wallner, Gabriele; Hann, Stephan; Laux, Monika; Cervantes Recalde, Maria F.; Jirsa, Franz; Neubauer, Elisabeth; von der Kammer, Frank; Hofmann, Thilo; et al River-derived humic substances as iron chelators in seawater Marine Chemistry (2015), 174, 85-93. Hanif, Muhammad; Meier, Samuel M.; Nazarov, Alexey A.; Risse, Julie; Legin, Anton; Casini, Angela; Jakupec, Michael A.; Keppler, Bernhard K.; Hartinger, Christian G. Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes Frontiers in Chemistry (Lausanne, Switzerland) (2013), 1, 1-7. Matczuk, Magdalena; Anecka, Karolina; Scaletti, Federica; Messori, Luigi; Keppler, Bernhard K.; Timerbaev, Andrei R.; Jarosz, Maciej Speciation of metal-based nanomaterials in human serum characterized by capillary electrophoresis coupled to ICP-MS: a case study of gold nanoparticles Metallomics (2015), 7(9), 1364-1370. Pichler, Verena; Goeschl, Simone; Schreiber-Brynzak, Ekaterina; Jakupec, Michael A.; Galanski, Markus; Keppler, Bernhard K. Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G2/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines Metallomics (2015), 7(7), 1078-1090. Schreiber-Brynzak, Ekaterina; Klapproth, Erik; Unger, Christine; Lichtscheidl-Schultz, Irene; Goeschl, Simone; Schweighofer, Sarah; Trondl, Robert; Dolznig, Helmut; Jakupec, Michael A.; Keppler, Bernhard K. Three-dimensional and co-culture models for preclinical evaluation of metal-based anticancer drugs Investigational New Drugs (2015), 33(4), 835-847. Kowol, Christian R.; Nagy, Nora V.; Jakusch, Tamas; Roller, Alexander; Heffeter, Petra; Keppler, Bernhard K.; Enyedy, Eva A. Vanadium(IV/V) complexes of Triapine and related thiosemicarbazones: Synthesis, solution equilibrium and bioactivity Journal of Inorganic Biochemistry (2015), 152, 62-73. Enyedy, Eva A.; Meszaros, Janos P.; Domotor, Orsolya; Hackl, Carmen M.; Roller, Alexander; Keppler, Bernhard K.; Kandioller, Wolfgang

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Comparative solution equilibrium studies on pentamethylcyclopentadienyl rhodium complexes of 2,2'-bipyridine and ethylenediamine and their interaction with human serum albumin Journal of Inorganic Biochemistry (2015), 152, 93-103. Tuerkcan, Adrian; Scharinger, Bernhard; Grabmann, Gerlinde; Keppler, Bernhard K.; Laufer, Guenther; Bernhard, David; Messner, Barbara Combination of cadmium and high cholesterol levels as a risk factor for heart fibrosis

Toxicological Sciences (2015), 145(2), 360-371. Heffeter, Petra; Kowol, Christian; Berger, Walter; Keppler, Bernhard Preparation of cobalt(III) complexes with 2,4-pentanedionato and N6-(2-aminoethyl)-N4-(3-bromophenyl)quinazoline-4,6-diamine for the treatment of cancer Eur. Pat. Appl. (2015), EP 2924045 A1 20150930. Kandioller, Wolfgang; Kubanik, Mario; Bytzek, Anna K.; Jakupec, Michael A.; Roller, Alexander; Keppler, Bernhard K.; Hartinger, Christian G. The rearrangement of tosylated flavones to 1'-(alkylamino)aurones with primary amines Tetrahedron (2015), 71(47), 8953-8959. Hoefer, Doris; Varbanov, Hristo P.; Legin, Anton; Jakupec, Michael A.; Roller, Alexander; Galanski, Markus; Keppler, Bernhard K. Tetracarboxylatoplatinum(IV) complexes featuring monodentate leaving groups - A rational approach toward exploiting the platinum(IV) prodrug strategy Journal of Inorganic Biochemistry (2015), 153, 259-271. Garbutcheon-Singh, K. Benjamin; Galanski, Markus; Keppler, Bernhard K.; Aldrich-Wright, Janice R. Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline)(1R,2R,4R/1S,2S,4S)-4-methyl-1,2-cyclohexanediamine)platinum(II)]2+ (PHEN-4-MeDACH) Inorganica Chimica Acta (2015), 441, 152-156. Oehninger, Luciano; Spreckelmeyer, Sarah; Holenya, Pavlo; Meier, Samuel M.; Can, Suzan; Alborzinia, Hamed; Schur, Julia; Keppler, Bernhard K.; Wolfl, Stefan; Ott, Ingo Rhodium(I) N-heterocyclic Carbene Bioorganometallics as in-vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling Journal of Medicinal Chemistry (2015), 58(24), 9591-9600. Kurzwernhart, Andrea; Mokesch, Stephan; Klapproth, Erik; Adib-Ravazi, Mahsa S.; Jakupec, Michael A.; Hartinger, Christian G.; Kandioller, Wolfgang; Keppler, Bernhard K. Flavonoid-Based Organometallics with Different Metal Centers - Investigations of the Effects on Reactivity and Cytotoxicity European Journal of Inorganic Chemistry (2016), 2016(2), 240-246.

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Schmidlehner, Melanie; Flocke, Lea S.; Roller, Alexander; Hejl, Michaela; Jakupec, Michael A.; Kandioller, Wolfgang; Keppler, Bernhard K. Cytotoxicity and preliminary mode of action studies of novel 2-aryl-4-thiopyrone-based organometallics Dalton Transactions (2016), 45(2), 724-733. Krachler, Regina; Krachler, Rudolf F.; Wallner, Gabriele; Steier, Peter; El Abiead, Yasin; Wiesinger, Hubert; Jirsa, Franz; Keppler, Bernhard K. Sphagnum-dominated bog systems are highly effective yet variable sources of bio-available iron to marine waters Science of the Total Environment (2016), 556, 53-62. Theiner, Sarah; Schreiber-Brynzak, Ekaterina; Jakupec, Michael A.; Galanski, Markus; Koellensperger, Gunda; Keppler, Bernhard K. LA-ICP-MS imaging in multicellular tumor spheroids - a novel tool in the preclinical development of metal-based anticancer drugs Metallomics (2016), 8(4), 398-402. Legin, A. A.; Theiner, S.; Schintlmeister, A.; Reipert, S.; Heffeter, P.; Jakupec, M. A.; Mayr, J.; Varbanov, H. P.; Kowol, C. R.; Galanski, M.; et al Multi-scale imaging of anticancer platinum(IV) compounds in murine tumor and kidney Chemical Science (2016), 7(5), 3052-3061. Meier, Samuel M.; Gerner, Christopher; Keppler, Bernhard K.; Cinellu, Maria Agostina; Casini, Angela Mass Spectrometry Uncovers Molecular Reactivities of Coordination and Organometallic Gold(III) Drug Candidates in Competitive Experiments That Correlate with Their Biological Effects Inorganic Chemistry (2016), 55(9), 4248-4259. Schreiber-Brynzak, Ekaterina; Pichler, Verena; Heffeter, Petra; Hanson, Buck; Theiner, Sarah; Lichtscheidl-Schultz, Irene; Kornauth, Christoph; Bamonti, Luca; Dhery, Vineet; Groza, Diana; et al Behavior of platinum(IV) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation Metallomics (2016), 8(4), 422-433.

Novak, Maria S.; Buechel, Gabriel E.; Keppler, Bernhard K.; Jakupec, Michael A. Biological properties of novel ruthenium- and osmium-nitrosyl complexes with azole heterocycles JBIC, Journal of Biological Inorganic Chemistry (2016), 21(3), 347-356

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Flocke, Lea S.; Trondl, Robert; Jakupec, Michael A.; Keppler, Bernhard K. Molecular mode of action of NKP-1339 - a clinically investigated ruthenium-based drug - involves ER- and ROS-related effects in colon carcinoma cell lines Investigational New Drugs (2016), 34(3), 261-268. Terenzi, Alessio; Lotsch, Daniela; van Schoonhoven, Sushilla; Roller, Alexander; Kowol, Christian R.; Berger, Walter; Keppler, Bernhard K.; Barone, Giampaolo Another Step Toward DNA Selective Targeting: NiII and CuII Complexes of a Schiff Base Ligand able to bind gene promoter G-Quadruplexes Dalton Transactions (2016), 45(18), 7758-7767. Orlowska, Ewelina; Roller, Alexander; Wiesinger, Hubert; Pignitter, Marc; Jirsa, Franz; Krachler, Regina; Kandioller, Wolfgang; Keppler, Bernhard K. Benzoic hydroxamate-based iron complexes as model compounds for humic substances: synthesis, characterization and algal growth experiments RSC Advances (2016), 6(46), 40238-40249. Blazevic, Amir; Orlowska, Ewelina; Kandioller, Wolfgang; Jirsa, Franz; Keppler, Bernhard K.; Tafili-Kryeziu, Myrvete; Linert, Wolfgang; Krachler, Rudolf F.; Krachler, Regina; Rompel, Annette Photoreduction of Terrigenous Fe-Humic Substances Leads to Bioavailable Iron in Oceans Angewandte Chemie, International Edition (2016), 55(22), 6417-6422. Leyma, Raphlin; Platzer, Sonja; Jirsa, Franz; Kandioller, Wolfgang; Krachler, Regina; Keppler, Bernhard K. Novel thiosalicylate-based ionic liquids for heavy metal extractions Journal of Hazardous Materials (2016), 314, 164-171. Bijelic, Aleksandar; Theiner, Sarah; Keppler, Bernhard K.; Rompel, Annette X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism Journal of Medicinal Chemistry (2016), 59(12), 5894-5903. Bonsignore, Riccardo; Terenzi, Alessio; Spinello, Angelo; Martorana, Annamaria; Lauria, Antonino; Almerico, Anna Maria; Keppler, Bernhard K.; Barone, Giampaolo G-quadruplex vs. duplex-DNA binding of nickel(II) and zinc(II) Schiff base complexes Journal of Inorganic Biochemistry (2016), 161, 115-121. Fischer, Britta; Kryeziu, Kushtrim; Kallus, Sebastian; Heffeter, Petra; Berger, Walter; Kowol,

Christian R.; Keppler, Bernhard K. Nanoformulations of anticancer thiosemicarbazones to reduce methemoglobin formation and improve anticancer activity RSC Advances (2016), 6(61), 55848-55859.