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Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends

Lucine Health Sciences

Real World Data for Real Life Decisions


Data Matter

One cannot practice medicine, make

personal healthcare or business decisions

without accurate data.


50%

OF MEDICAL INTERVENTIONS UNPROVEN

ONLY 35% KNOWN TO BE BENEFICIAL

Source: Greenhalgh, Trisha. How to read a paper: The basics of evidence-based medicine. John Wiley & Sons, 2014.2


70%

OF OB/GYN CLINCAL PRACTICE GUIDELINES

NOT BASED ON EVIDENCE

Source: Obstetrics & Gynecology: September 2011 - Volume 118 - Issue 3 - p 505–512


Lucine Health SciencesHealth data for the real world

LucineHealthSciences.com


Fundamental Assumptions • The way we investigate medication risks is flawed

• Not gender specific: clinical testing before 1998 did not include women; drug development before 2014 only included male animals

• Too narrow in assessment of what constitutes side effects

• Too static: only experts can recognize/report a side effect

• Too broad in the analysis of population based risks, when what we need are methods to assess each patient’s individual risks


Resulting in• Underestimate of real risk for any given

individual, but especially, for women

• Inability to assess medication, health, and lifestyle interactions

• A lack of recognition of important side effects by all involved

• Lives lost to predictable side effects, had anyone looked.


We Need• A more open conversation about side effects

and risks

• A more comprehensive approach to understanding drug effects

• A better, more personal math to describe the risks

I need to know that given my health characteristics and my lifestyle what my risks are


Risks have numbers (weights)• Identify the side effects and the patterns

• Patient characteristics

• Symptom expression

• Event occurrence

• Predictors of impending event

• Find the math• Set the algorithms

• Understand individual risk • Given XXY characteristics, what is my risk for blood clot?


Research Philosophy• Listen to patients • Self-reported case histories have tremendous value

• Discovery comes from unfiltered interaction • Patients, researchers, and medical professionals

• No silver bullets just tipping points• Health and disease are complex, dynamic algorithms

• Nothing happens in a vacuum• Everything is connected


Dialogue

Knowledge

Insight

The Process • Open the

dialogue on side effects

• Build the knowledgebase

• Inspire more research

Save lives


Hormonesmatter.com


Hormones Matter• ~1000 articles published to

date• 3-4 articles per week• Patient histories and research

analysis

• 70,000-100,000 views per month

• 150 guest contributors/writers • 18 PhDs, 5 MDs, 2 DPTs


Patient stories

Research

More stories and research

Patient stories present research questions and patterns

Leads to mechanism research, then to online survey research

Online studies inspire more stories, publications, and collaborations

Integrated


Insight Accrued•Medication reactions • Attack the thyroid (Hashimoto’s)• Systemic, not limited to intended target • Derail mitochondrial function • Induce/exacerbate nutrient deficiencies (which

further derail mitochondrial functioning)• Thiamine, Magnesium, CoQ10, Vitamin D, B12,

others

• Rare mutations are not so rare (just unmeasured)


Current Project• Birth Control and Blood Clot Study

• Privately funded, multiphase project to develop risk calculator

• Phase 1 completed; 3 reports published online, more coming

Major finding: among women who develop birth control induced blood clots, in

younger, more active women the clots are more likely to be fatal than in older less

active women

• Phase 2 data collection in progress


In Review• Lupron Side Effect Study• ~1000 respondents • 1st report published online; additional reports

forthcoming

Major finding: moderate to severe global side effects affecting 15-90% women depending on symptom,

with only non-clinically significant, temporary reduction of the symptoms for which it is prescribed.

Some side effects appear to be chronic.


Ongoing Projects• Gardasil Study

• 1900 respondents, open

• Fluoroquinolone Study


• Hysterectomy Outcomes


• Oral Contraceptive Use

• 900, closed, analyzed, unpublished


Chandler Marrs, PhD• Specialties

• Big messy data sets and complex systems•Medication adverse events• Mechanisms of action and pathway mapping• Medication induced mitochondrial

dysfunction (and repair)• Hormones • Neuroendocrinology, neuropsychiatry


Chandler Marrs, PhD•Writing

• Hundreds of articles on diverse topics•Medical Textbook Chapter • Micronutrient Deficiencies and Mitochondrial

Dysfunction. In Integrative Therapies for Depression. J Greenblatt and K Brogan, Eds. Taylor and Francis Group, LLC. FL. (2015)

•Medical Textbook Co-Author• Thiamine Deficiency Disease, Dysautonomia and

High Calorie Malnutrition. Elsevier. (Spring 2017)


How may I help with your projects?


Thank you.

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