jak inhibitors from selleck

Inhibitors of JAK/STAT Pathway

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Dear customer,

Based on your research area, Selleck has special recommendations for you on our inhibitors of JAK /STAT pathway currently targeting JAK.

Cat. No. Inhibitor Name Purity

S2162 AZD1480 >99%

Bioactivity: AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of0.26 nM.

S2179 LY2784544 >99%

Bioactivity: LY2784544 is a small molecule selective mutant JAK2 kinaseinhibitor with an IC50 of 68 nM.

S2686 NVP-BSK805 >99%

Bioactivity: NVP-BSK805 is a potent and selective quinoxaline JAK2inhibitor with IC50 of 0.48, 0.56 and 0.58 nM for JAK2 JH1, FL JAK V617Fand FL JAK2 wt, respectively.

Applications & Feedbacks

AZD1480 <More> LY2784544 <More>

Papers Using Selleck Inhibitors

AZD1480

Deshpande A, et al. Kinase domain mutations confer resistance to novelinhibitors targeting JAK2V617F in myeloproliferative neoplasms. Leukemia.2011 Sep 16. doi: 10.1038/leu.2011.255.

More Inhibitors TargetingJAK

AG-490 AT9283

AZ 960CP-690550(Tasocitinib)

Cyt387INCB018424(Ruxolitinib)

TG101209

More Inhibitors of the JAK/ STAT Pathway

by Target

STAT

More Inhibitors of SelleckSignal Pathways

by Pathway

Apoptosis

Cell Cycle / Checkpoint

Ion Channel

TGF-beta / Smad

by Research Area

Cancer

Immunology

Inflammation

Metabolic Disease

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http://www.selleckchem.com/newsletter/s/05-05-2011.html



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http://www.selleckchem.com/pharmacological_Jak_Stat.html

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http://www.selleckchem.com/products/LY2784544.html

http://www.selleckchem.com/UploadFile/Image/WB_PIC/large/AZD1480-S216201W0120110331(1).gif

http://www.selleckchem.com/UploadFile/Image/WB_PIC/large/LY2784544-S217901W0120110331.gif

http://www.ncbi.nlm.nih.gov/pubmed/21926964





http://www.selleckchem.com/products/AG-490.html

http://www.selleckchem.com/products/AT9283.html

http://www.selleckchem.com/products/AZ-960.html

http://www.selleckchem.com/products/CP-690550.html

http://www.selleckchem.com/products/CP-690550.html

http://www.selleckchem.com/products/Cyt387.html

http://www.selleckchem.com/products/INCB18424.html

http://www.selleckchem.com/products/INCB18424.html

http://www.selleckchem.com/products/tg101209.html

http://www.selleckchem.com/pathways_Stat.html

http://www.selleckchem.com/pharmacological_Apoptosis.html

http://www.selleckchem.com/pharmacological_Cell-Cycle_Checkpoint.html

http://www.selleckchem.com/pharmacological_Ion-channel.html

http://www.selleckchem.com/pharmacological_TGF-beta_Smad-Signaling.html

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jak inhibitors from selleck

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