JACC: JAN 22, 2019

Dec 18, 2014

THE STUDY:

“HDL PARTICLE SUBFRACTIONS IN HEART FAILURE WITH

PRESERVED OR REDUCED EF .”

JACC: JAN 22, 2019

PRIMARY ENDPOINT: ALL CAUSE MORTALITY

SECONDARY ENDPOINTS: DEATH, MI, CABG, PCI

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JACC: JAN 22, 2019

HDL PARTICLE SIZE AND STRUCTURE EXAMINED

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• HDL SUBFRACTIONS MODULATE KEY PATHWAYS IN HEART FAILURE AS WELL !

HDL

WHAT IF HDL ( THE GOOD CHOLESTEROL) IS NOT

DOING ANYTHING GOOD, AND HOW CAN WE

TELL?

HDL-C= 60 mg/dl HDL-C=60mg/dl

I’m functional I’m non-functional

CAN HDL CHANGE FROM ANTI-ATHEROGENIC TO

PRO-ATHEROGENIC ???

HDL:

ANTI-ATHEROGENIC OR

PRO-ATHEROGENIC ????

Ansell BJ et al. Curr Opin Lipidol 18;427.2007

Davidson MH. et al. Therapeutic Lipidology . Humana Press 2007

GLOBAL VIEW OF HDL PROTEINS

J Clin Invest 117: 746, 2007

SMOKING AND HDL …………

DON’T FORGET ABOUT HDL !

•THE SECRET OF SUCCESS IS THE

CONSISTENCY TO PURSUE