j j j - nite...i3 45 , 2003 l:-+ ytdil=i ;b* lit: !,{b?!.7'.)p o mg/kg, 0.4 mg/kg, 2 mg/kg, lomg/kg,...
TRANSCRIPT
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172
.! !j j 0> ! !i (2003 . j )@>;i i i; l
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Cll Br
[CAS N0. 74"83-9] ! ;!j i l pp, n (3.89 , jig/m. 3) (j ,,)
SFjj ; 15 ,j 4 )S 25 BB ;*:. ; ifE:t,
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l, ;f1:QE {1: ,j ' !;ny:it ?: ?'. JV7'D ? -4' F LMethyl bromidel , '7't, .
>t ' :.' tBromomethanel.5f" ,. ft 94.95, t1:: ; 20 t: 'C' 1.68, ,!;, - 93.66C , i
3.56t: $:: 1;E 1420 torr (20 t: ) , $:j j l. 73 g/cm' (O C) , ;i" . ' > , . . F :>. n n / >.. != rj ;, :i g,1; $ -J:. 1!
15 %TF! LO%, F3 1 !i< ' ' C, *! f:!., 1 ;i&;!; 'C!t*!i1, E* :'C';t>.>,.
:;i 7 7 ' ' ~ 1 Ppm ' 3.89 mg/m', i mg/m3 =O. 26 ppm (25 C 1013 hpa)54)
2. . ;fi**s J: 0, ! 3 @?fi *?*'1 !!CbS!*.*, E:,{b?t 9" JP@>!; ;tld:* j Eff < A,
1 !: :L!*gtl :i } < A, ; 175*:/C' 1;53'7:', 1 ~ 2 % i ?! +)v{!: i2: L. t{b:@, .>!b1=j; #?*Ltv. . ; ;,:lc !d:, jj }1< 1 !: 1, t{ *>*Lt= . !:7ir35 .s, 7b', fEi$; 'iS:0 *E7b' . <
C O El t:'@>{ ! !d:1;,iL. *'Lit:. 1999 fl7, t>7b } U * - )V;ti ' 3* 1 ;;fJ *5 v*'C, ,{j:?t +'. iVjd, t. v'>.'! 1 :! ! j (:d' />'1
:g!!{:; : 0.6) !=tit;i *'Lt= . 1997 ,13 (' F ii, 9 !:) @> 9ji * 1 1 ';i$ ?i*, 513i 1 11*, 2St!E i3 (1991 =) 6b
: !.** b t 2003>1: 1. !* 30%i;!T l= 11i
i , 2005 17('Fii! 17 ;p) 1= 1, : :1;E " s, C !: 7btt,;; *Lt::. ;:: *5, *ja
!1 1j: ;;t < A, ;;, j!: LCO>{ i;lld:{ : lj**; :v. /::at>, c. @> jj ; +j! 7!. , 1 ,'F *'L*:. * 4 j ; jH :: Lt@?{ : 0>
17f3'Bld:i ti'1*, Z:'; ,.l) ,:!:t < A, 'C'@>! '3 8: < A, ; {'F;@:!: LtA , > X
Eii, /\ ,> X l*1? iL, .,;3 3: 0t3 g;@ ?'JV. 9. < A, ; ib**5 s,. : ti@ jl=. t! : :. t,: t, , 500 g:;6'C A, @>,! f6. :. ;j 1! !=
, ,i4 q ....>. P > 7 4 )VA 'C',:! '&t;i!S Lt:t , !;*{b?!
l 1
.7'.)Pf:. 1 :;f; " ,>, . . L T 3 B . f, 7 B ft51 :tEt U t:i :, 74 )V. A , 1 - L, t : 'xj ; . j ;j . { 'ld:1 ; !: : V;<
jjj mf*{c,,,{j:?! 9". iV!=1! 3 i'L;3, i ;! 7 ';6 . ,. {'F : '@>
l , tg:1t, !: < !C7 V>!. t!: R !=jgj < At7 :t. i, i? )V+ < A, ; 'C ld 1, - '
248 ppm, 3Sfi@ ?rP, 7'. z?!i* 1 , ' - ' 0.9 ppm 'C;6 ,>, . /\ ,>'X itii < A, ld:, A ,> >: :;y7. t$: '$:jj'
;> . *f. 4 . < A, !;'C lt:, !,{1:?! .)v :. , 1 7 ,1 /\" , i&ljE!d:, ,!d; b :b'; , != V.5 . ;::*;S, C *'L G, @>{'p : '1*, !;{L?! C" JL. Ff9&. 1Xf {t
: :jEjj:$U '1!t {;; 3 , '4@; L'Cf : 'fjo tv*, 6 1. 2).3. gjjj!1!i""
" ,, 1!Efg;, ii!Elrish i 1d ' y } 2: ,> .*.\'t?@>tE {b?! .C.),@>; !.' j4;
:. f9B Li:=. 260 ~ 500 ppmi;!L. O i!t1;E'C@D l l 1, j:U iiQ 3S ld:ii@""! 7:'; :*EBf 'C';*> s) : * ; U i: "). Sayers
, 0 ,e iV .E v } @> !1;; 'C' f> 1 1 U J: ;j ,g: * i:;t:. a:, sj 5) .
Alexeeff G, 1*: ? ,> X O l ll ; llW l! a8; t O>. LC50 1 l. 200 ppm 'Ce:, ly , i9!iE: ;. J& ioo%f!: : ;!: ioo%fBi= ;75ci i L. t*a'? !{b?t @" )P@D; ' jg:'@>-OO ld: " aU or hoiie
" . @, ,,*, , *E . i, t, 3) .2) "1 '1 *g;'1 Sprague-Dawley ttE' ' v l~ !=, .! ,{1:>t . ?" )V@> 120 ppm
'C 24 U ; a, : i:: 1* 10 ppm t:' ; t3 ; 1;61 7*1 E U/: fgS. c*;;t, t j T B, jE:j9j'!: j , 8; icf:sij, >" / iL. .z. t:' *. 7 ,j
>jg!j;e7j*j;j _ { :j :j j= * ~ u/:, 7) , , r , .,e jp, e y}j*, 4*., u !=, sv t, lOO ppm 2 ~ 3 i!a 1*3@>q,;7*1 jg;'C'
j!El; ' : t: 1 : :>Ettgt:' >; 4) .Danse ,;, 1d , Wister ' y } ( -ll "t, ;tj9 - 10 1!*) 1.
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l:-+ ytdil=i ;b* Lit: !,{b?! . 7'.)P O mg/kg, 0.4 mg/kg,2 mg/kg, lO mg/kg, 50 mg/kg (4:h ) g:' 90 B ffiO>
7 > 5" ii !t.'!', ,1 f B E:'4 0 it:. 50 mg/kgt :J -t'1*:, ' !jt;,!= L. tiitr i 5 FJ=! ;anl L tll (t 2 EE) : t= 1,j tr 7jtA, (tjt 7 1!9, ittt 6 p*) 75
.L, V. jg:j@:-{E: '1:g0;15 . , C !: *'t:q Q, *Ltv. ,s, 13. 14),3) ,1 1g: '19;/3Eib3A, ,1 lrish i;, 1d, j j . ;:*!jtr!1"t:, {j:?t +.)P0, , 19;; ;, :. f
gE L t::. 64 ppm :' 7 ~ 8 , ;1!5/ B , 6 , ')g 1;8 !;!L. @>li;;,g:'C, y F !: ,E)V, 'E v } t;1;t q ;, *.!g::j,, lj g j!7jS , Q,
*L;:***o i:. 75* * ' E"@13:1,@> ; !:t :A ::6* ,*L,,i')Pld t l i ;!jt'C'; ,;*; 'i E L t:. 33 ppm t:'1d, t7 '\1d:
mji0 :; tt:.*5 J: U' "*4 . L, *:ib* . 0>{ 0 j! j= j, : i,!jj*;: ;b*o i:. 16 ppm 'Cld, '$~'1 *!d! g* jLj 6~ 8 ia1!5 != !,: 1;5 . 'c, it t*, 5, j5*jj U ;t: " ). t j u <
, - y \ j= 55 ppm, 36 ;B a , ;; ; f 1.080 R*!lia @>1 ;}. 1g'3S:cl, j::jtjg8'C'!,, *llli;E{ : j"gE, :;' - 7 > 7 4 -)V l?jh' j,
j!gtg:j g3j g;;;*:0**j j artri :*s j *Lt: 16). 7 ,>;:.@>. 1! 19:1! 3g f38C'!,, ; , j j :@> .@g8 E; *L*: !:j jj 0F :{1:ij*'i3:t J: b *, ,!>ti:v*ft. c, ! . ct: 14).
? *, ;!.*3 J: t F y 1* @>1! 7*1;h38-*".; .' C'1*:, * ,{b?! " )V@> j;jj!Eid g Q, ;E*lC *'Li:::6t C O { T'C1d, 3gi5*/;.,'j! 1, ;g: . 0 ?:: 14. 17).
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400 ppm 6 i!3Ra
tlE!lt i. 70 E* :' 1;1 V. t *!,{1: ?! 3" )P O ppm, lO ppm,33 ppm, LOO ppm, 6 a ! li5/B 5 !a /iB , 2,13 11W O!!4;}..IB 3gh1f9g 'j 0 'CV. s,. i t 1 1 $ $; (100 ppm) 'ti*:,
. h!Ui Ji5* .a;:EBi= L;t:7= ;6 (tg 31 %, 1 8%) , ! 3ht, 20 i!at:'lt. Lt: fL/=. lO ppm t, lt, ' 'jj ! ;: '0>1 . :5 ' E. : ;!8"!lj; j 0;1*: 0 j 3 76* . iQ *Lt v. ,s 14) .
Reuzel lQ 1d , Wistar E , ittj ' y F != , . ,{j: ?! ;;'. )VO ppm, 3 ppm, 30 ppm, 90 ppm ;:' 6 U :i!8/B , 5 B/; ,
29 ,E~!E 0! . 7. ! Eh : . 4 0 t:. , 15'C4)B 3 i= 6>l= 3 ! 'it , i2 #'it , 24 6" ) 1 !=- @> ' y F $:. ,;4; U
i:=. ' ; 1EBl=1,, igii!,!*:3hti' L14 i9 B != ;;,!=48J$ *Lit:. , i ! L. *:0 ; an !:' ; 1 0 i j 1 /; i
:{1:75ti9:*E-j '1 1=** " Ut:. C 4>; !,;i i j , j;t, .p* ;gg!:5J i ; *Lt=. ; : {bi 3$@'lt, !aggO *$.)g (29 !t ) 'C:! f t&!t51 Ea F (3 ppm) !:*t gh!= Oj;a!=: :*: 7b* . tH *'L/:: 17).
Gotoh Q, 1, :, Fisher344 y F i! , t1$45. 8g50 PEl=, * ,{b ?! .?*. )P O ppm, 4 ppm, 20 ppm, lOO ppm ' 6 /
B , 5 B/i , 104 i!Ella1! . 7*!4 ,$: Uit:. @b ;*@D8Ei= 1= 1*3 E{1:76* . 1 *L :*. o t::fyS, . fi 1 L. ! @>; 7E t:1 ! Ll \@>{1: E. :6*t!EO IOO ppm8h'C*J U U t:. :! ti:0. E !: j :!;, 1,, i:!E v } @> :i! 3 E:3g'C'i"llrr U/= (20 ppm !:IOO ppm 'C';'; + ;:6g1c*jj ) . t 2: A, " /< 'C@> ; !d : * ' v } 't' . < 3h!1L " .5,; !1a, t 75. : t:1,:1 !
L. !J. 0 ;; t:t:'35 0 t:. ilgt:'1, :, 100 ppm lg'Eg8g1=0;;Ll! LgZO! EBj: ; @>j .g:ta;trU7b3 .. 1Q*L*:. m* ;@>ggEE
.;EEE. ';" ;L, TE*{*1;!1"3g4EE;i:O*g U7bt @> lOO ppm 8\!= g;t> , *'Li::*S, C @>M ;@>ti!l"!,, '{1:?t +iP!C ,1: . , i iP > , ' i::13:1iUfi*{ i!6{
lC J: , , ;> Ot:'z6 0 .;E;b*A, j8:0* aLj: 1$:;g! g, : ,. !: L.cv, s . j!h. c, i;*ft!gJ$ga E@)t jj"!d . Q, *tg::j. o j:: 18).
4) ,t> i8' ;, 1 /. aL ' , ,{j:?! a,.)v!,, , t;E '!=aE. 1 ' 1! 3*:c', i ' g:* * , :{1:
!: mL h:. ' 7!.' } X .7' D :,' t&a:0 - i i t* >:jt g U 5, *'
F344itE v } 1=*:3 V. CO4j, jb?t " ), 200 ppm, 6fft:li8/B , 5 B ft8@>1 . 7. ! 3S:7:'!d:, * it+0?'EE : : /= !d} *e 1=
*t:i$ t';' .L, a *!li, :;;, E, *'i, *g:76* 0 /:: " '. wistar ; y l. t:',;t51;a 3 ia 1;5 : i:: 1*:!:EtE;, t, != ,{1: ?t
. )P 0 20 ppm ;:70 ppm ' C' 5 B/i !!J;7*! 3S L i::1*f*67?1,, ! f!:, ' , '1 j ::6;j9:$;3 J: CFl hi'ili i9:1;t*!. j> *L;:: 7 * 0 j:: 20). ., .,. _ ,,
- > }, ,> j. E2'C'0, ' y l* !: 1 1i&:i !', 6S L/= fi8'Cl:;, C. @>j&j E1, ,>, f'E"!C** t, C '1 75* : ' i=*:3b,
t!g 15 B !c 25 p8lt. 24 1!37538Bt: L i::. "!L- E j!g0 *:lE:'> 'g'\!,; 8 1!9@>,ji{E. :.. 1 1 j L 'cv*;:** j j{ !c '! !,;
9: *. , /;: 20) . /:: : L , jg: j-jj / .;j : ij!g :.* 18j';' .s *i' .!= L'Cl,, '. j @>;!a '@>' 1 ;tt:tb'*< 'Cl { :i5S >t* ' ';/, !: j, L;s .
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;j " ;~ ;J, C !: !d: 1 7j. 'C;t,.c,. .y. )y, e * ; L4. 21. 22) *s J,c)t:., ,j * :.? , ,>/g;g, , j :-i ;jt!;j!, i= i~ u ;,,/ k@>tii**;j t:!6;.{*=ej jE! 23), j ? * x g>* nn. t '}3v. t:t !* i
. 6 { *5t : u! *sJ: CRd : :i*v* > 1;*'1i!&t 3:, .c, 13) .6) ;\ gyi!i /{ 8!tBond i;, i3:, t" cj , )v !,{j:?! -?,.)v@> y } 1 .. 7.1 f
g ,$:'t'io C V*.c,. F344tj . y } 1=g!:{1:?:'?" )P 9 ppm , '6W,:1 11 2 '6, t:, ! lX 0 47%7b*= :{1: !: L 'Cll tB *'Li::. ll ;t"C'@> 1! ;;Fi *B @D= iu !d 3.9 1 R5 ,f !tft; iL*B0@j5ii&i;t 1d 11.4 Rt,Ra !: 2 *B' '@3:, 0 it=. li 3$i :t 0 i;;;$'@, . j A 7: b @>j ; : *t E*. 0 t:mg !d, lih (6.4%), 1 t' (6.2%), ' !16! (4.6%), 11'1!;!(3.3%),
,;EP/ir (2,8%) C:';6>0 /::. 11 @> *B. tuQ)iat:: '3*!d:* 4&:1X:B:@?'1 #' 10%!C : :' .o j 24).
{14cj : , iv ,{1, ?! +)v@> ; ! i 1d, 'i 1.1*:s J: 0*us"" 1'lt :!$."C'13fg3 *Lt: 25). j i j .C? jd:, t . '>43 %, *{ ;ii J !: Ut ;. FP !=;!Fillt *1-, rstl 1 i " " ",t; -: :@> 46 %75*= {b 5! !: U t U, ':*;, j. !=!t jL *'L,t, 25). . @> J: 5 j= ,{j, ?! + jV@>;!g!y, !, j ;1d1 E31 ;!=J; o t5$.;::. 6 . :{b?t 9" JV@>; : J!tfy ;! V. - , V. ;J, !: ! ,g}1 :i$; ' :.: . tl f9& *'Ltv. ,. Medinsky Q, ld:, F344 t!E ' v } ;= [" C] ' , iP :{b?:.?'. iV :., ,!.;6* , 50 n mol/!( ;:ti$), 300 n md/!, 5,700 n m01/!, 10,400 n m01/! (1.6~ 310 ppm) Ei! 6 ft$;Eall gg: L/=. j! j&j ! , 'COl =!: lt * 48% , 5,700 n md/!'C'!d 37% , 10.400 n mol/!'@lt 27 % != jg!1*:75* j'$'1 !='j 1u2 1, :j T L it:. C. @) C $:*. 1;,, 13t}* 1= J: ; , *!:{1: ?! .3")VOl, ! b ;Z, .!";fi *U $$ *L;5 !:":j -. .. i;, *L. 6, 26). ;$,. , v. !*, B, ,d G, @>$&{ . 24) ;: j jjg!!=,gt,{ X 9'.)P@?i&li*.5}'Z 2: F fl* !f@?!= :t' i !tgs ly , {1, ?t a.)V E:{ ;!t!1 @?;iFtlLl*! tS:t!t! J1= 1d:{ U , :v* !::;9, *? *L ,c' ,Honma l;, 1;t, y } '$:. jj! v. 'C ,{1:?! '. iVO{ j2: *!i
ii;;::;= 1!E ,E:. t: : t L t: . *:' {b ?! .*' " O LC, , 1,: 302 ppm(267-340 ppm) 'C';15 0 i::. ,=. 0;=':! ' , != J: b 49,1;, *'L7::g&{E?:'?'. Jl, @lEjd;;tild: * 30 6t.'C; , b , Bond l;, lC J:; b *& . *Ljt=jjjj24) g: O t, :7j* .0 /= . ,{j: ?t C,. jv jd:j*. 1:*i'C' ?! .3.iP7 ib =1 -)Vl=f ;!t t'L. ,:6< : :,jj 75*i;, j :, {j:?! a, .ivO*i i;3, i 19: ?:.E'. JP7 ), . -)V!= J: .5" {> @> !: "!ig.
. . , C 2: 1;3 '@ ;:: v. 27).
* i{!: ?: .7, - )y @>{ ;!j 28) ,j. q, j!e L. t, u!,{j: ,t a*. ,p !*3: t: )P ' '?" *' 7 'C' !, . jj\,:* ' i'L . , t> 0 : : '; ;. E, *'L25. 29). Yamanol$, lit ? '> X != {b ?! .?,. Ju
l. 945 mg/m' (500ppm) ' 1 ! 1!!!:7. .1!;3,8: L7::: i;g"C, 2l :!Bl : 'C'3Ei= i ;9:i5.0 i::b* i;, != 30 53' C? 1d Et=!*:
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:b* 85 % !: 9: 0 t:. $!,{1:?! '?" JP!;!;.}. 0 !C )P . . 3i' 77:' 500 mg/kg (j*:.: ) @>1 1 P!iib!- -, . L, i!:7 * X C'i :,3Ei= lt 5.3% !:; ' U < i ,!>' ',c' !: *&$ . ctv .c, 30).
[14c] , iu :, 4j: ?: C".)V it, i;3. 'C' $, ; i , 'C , A@:. D !,' :,' !: ; 3*' *j ."$:-. . , 31). !;{1:?! " )Pl! E : "C',\'E D 7 7 y ' } :btj 1 ' *L
j= 32). ,\, e ,?"' n j ' > 7 y ' j* @>jRl$i !d: {!:?!.a JV! !"3g; '0>JE!j=, @,t, E= U :,' *"!=;,'! '@ ,6, !:, , b*L5,.4. 1, 1. !=, slj'; '1 *&Alexeeff & Kilgore (1983) 1, :. '{1:?! 5'. iVrj. @>958
ll=ov*C : U'C v. . ,. 958 !01:*, 3Rl 3Ei= 115 : i,i : " 11, ; 523 : j, !;:. jj, j; , ; 185 g;j, rrl 1; : 57 : i,O{ 78 jt:'; ,;i, " '. LU . 1, , 1982'F~ 2003 ,F 2 i$ :'0*?7j3ET= 47 1!: F3Bi= 174 ! ' a$ L it:. ,' rl. ,: ,@>!1 iSt!d: @> ! :U< :'35 b ,3:7::, 1!gBgi*:;i , \u,$ L, :; :* ' n->: 7. }: $*. ' V>:;! 'CA. ,75. A, g { * Xt@> iE!;b ' ' L i::. ~,*{ ;1;t!$0> . iE!1 51,: ; 100 ppm :'C "tr Lit:. >'~)P *Li:: < A, g'?" *, :,'/*- @>jRl3 E{d';!t'C!;t, ;E$500 ppm, < A. -;;;jt:lC{j5; ;@t< A, .; .c'. + >.)f-}=}* 't'.c, != ld:, {t= !g: '0, ,. 0{ 18:'C l. OOO ppm ; '=g ; .
3:'C'!= 13gt:E=R5@>t 1 = E, :b* ,.6' != , 4
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'Cv. it:""'. Tourangeau !: Plamondon@>*Rf1i'Z:', fEl= l: i, q. 1 ii6t3isE Ut:T; ,'C'1d, : iSii!&j;E;6t390 ppm :,; , 0 /:: " '. Hjne j* 2 :f10 ,j. ,: , , :*':b*t;'j:::E;! 'C, Fqig!j;j!3:*: 100ppm ' C'; > o i:: !: $Rf ' L j: " '. johnstone!d , . '- j. = /* y ,j. - y 1*" 'z:' . t:@> .p": f91 (34 : i) '*R i Lt:. 7b U 7 * JP= 7i'llf td!i ,
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l) EBit. . :,{1:?! ?,. ivo{ j;jjjJtj;1!:f : ;6 . j j3 1999;41 (!:giij;f +t .) 140.
2) Tanaka S. Abuku S, Seki Y, lmamiya S. Evaluation ofmethyl bromide exposure on the planc quarancine fumi-gators by environmental and biological monitoring. fridHealth 1991; 29(1): 11-21.3) :6i*i '7'. aa, ;,{E ?! '. iP ;. B * < A, j tiij .1989; i;:. 125.
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IO) 1
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soning in mice. Acute inhalation study and the eftect ofglutatione as an antidote. jpn j lnd Health. L991; 33:23-30.
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48) ili9fl, E '., 1 1 - K, :E 1 \. :E'i*i .. f*y }, x, -
X :Y7. ? . F l:? 7 4 -1. J:,f, ?1 +JV70 ? ., j }et!E;!:: 'O nn!! q. :,{1:E*14 :1~ 7 0 Mi i it:. :!:1 2 i987;29!3): 196-20i.
49) ;5*12i ;i'., hUi { i!t, { q, EE 1, LU9fBE'F. , 1fl3 :~9B. :a'li 1 tf: '1=3 ' =. Ut: , $ {1:?! 'JPq.: . 5
j :E;: i988; 30(1): 54-60.
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