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Marc Imhotep Cray, M.D.

PATHOPHYSIOLOGY OFDIABETES MELLITUS

Prepared and Presented by:Marc Imhotep Cray, M.D.

Companions:WEBPATH

Endocrine Pathology IndexClinical:

E-Medicine ArticleDiabetes Mellitus, Type 2

A Review

http://www.caninsulin.co.uk/pathophysiology-algorithm-p.asphttp://library.med.utah.edu/WebPath/ENDOHTML/ENDOIDX.htmlhttp://www.caninsulin.co.uk/pathophysiology-algorithm-p.asphttp://www.emedicine.com/emerg/TOPIC134.HTMhttp://www.emedicine.com/emerg/TOPIC134.HTMhttp://www.emedicine.com/emerg/TOPIC134.HTMhttp://www.emedicine.com/emerg/TOPIC134.HTMhttp://www.emedicine.com/emerg/TOPIC134.HTMhttp://www.emedicine.com/emerg/TOPIC134.HTMhttp://www.emedicine.com/emerg/TOPIC134.HTMhttp://www.emedicine.com/emerg/TOPIC134.HTMhttp://www.emedicine.com/emerg/TOPIC134.HTMhttp://library.med.utah.edu/WebPath/ENDOHTML/ENDOIDX.htmlhttp://www.caninsulin.co.uk/pathophysiology-algorithm-p.asphttp://www.imhotepvirtualmedsch.com/

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Pathophysiology ofDiabetes Mellitus

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http://www.nurseminerva.co.uk/diabetes_mellitus.htmhttp://www.imhotepvirtualmedsch.com/

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Properties of IDDM* and

NIDDM**Characteristic IDDM NIDDM

Genetic locus Chromosome 6 unknown

Typical age of onsetUsually < 40 years of

age

> 40 years of age

Plasma insulin Low to absent Normal to high

Plasma glucagon High, suppressible High, resistant

Acute complication Ketoacidosis Hyperosmolar coma

Insulin therapy Responsive

Responsive to

resistant

Response tosulfonylurea drugs

Unresponsive Responsive

* Insulin-dependent diabetes mellitus**Non-insulin dependent diabetes mellitus

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"Inputs to alpha cells and effects of glucagon,including negative feedback, which increases plasmaglucose levels"Robert H. Parsons, Ph.D., Rensselaer Polytechnic Institute

Alpha cell stimulation

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Beta cell stimulation

"Inputs to beta cells and effects of insulin,including negative feedback on glucose andamino-acids levels."Robert H. Parsons, Ph.D., Rensselaer PolytechnicInstitute

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