iutox 2010 barcelona xii international congress of …tox.umh.es › iutox2010 › iutox2010_page...

XII International Congress of ToxicologyBarcelona-Spain 19-23 July 2010

BARCELONAIUTOX 2010

www.iutox2010.org

Spanish Association of Toxicology Federation of European Toxicologists &European Societies of Toxicology

XII InternationalCongress of ToxicologyBarcelona-Spain 19-23 July 2010

2

Your research Our support Harlan Laboratories Contract Research Services

Pharmaceuticals/Biotech

Chemicals

AgroChemicals/Biocides

With a presence across 12 countries, Harlan Laboratories Contract Research Services offers local expertise with international reach. Factor in our scientific excellence and a focus on customer service and you can be assured that we really can help you do research better.

For more information visit www.harlan.com/crs

©2010 HHarlan, Hbetter, anLaborator

www

BARCELONAIUTOX 2010

ZWHPUZZWHZWHZWZWHZWHZWZWWWHZZZ PUPUUPU

3

INDEX

CONGRESS COMMITTEES 4

SOCIETIES COMMITTEES 5

VENUE 7

GENERAL SUMMARY TIMETABLE OF THE CONGRESS 8

SCIENTIFIC PROGRAM 10

19 JULY, MONDAY 1020 JULY, TUESDAY 1321 JULY, WEDNESDAY 1922 JULY, THURSDAY 2523 JULY, FRIDAY 31

BUSSINES MEETINGS 34

TOXICOLOGY HISTORY ROOM 34

POSTERS 36

EXHIBITION AREA 94

SPONSORS LIST 97

GENERAL INFORMATION 125


4

CONGRESS COMMITTEES:

Congress Honorary President Eduardo de la Peña de Torres

Congress Organizing Committee Eugenio Vilanova (Congress President) (*) Arturo Anadón (VicePresident) (*) Miguel Angel Sogorb (General Secretary) (*) Miguel Borrás (Internacional Industry Liason) (*) Roser Cruz (Spanish Industry Liason) (*) María Aranzazu Martínez Victoria Carrera Jordi Estevez Joaquín Lapuente Joan María Llobet Encarna Quesada María José Ruiz Carmen Estevan Kai Savolainen (President IUTOX) Guillermina Font Perez (President AETOX) Corrado Galli (President EUROTOX)

(*) Financial Comité

National Scientific Committee Ana Ferrer Dufol (Chair person) Ana Bermejo Ana Cameán Domingo Gargallo Antonio Hernández María Anunciación Lafuente Jordi Llorens María Rosa Martínez Larrañaga Santiago Nogué Guillermo Repetto Francisco Soler Rodríguez Victor Sorribas Joan Vericat

International Scientific Program Committee

Ana Ferrer Dufol (Chair person) Linda Birnbaum (USA) [Chair IUTOX Science Commission] Arturo Anadón (E) Herman Bolt (D) Allan Boobis (UK) José Vicente Castell (E) Kevin Chipman (UK) Daniel Cyr (Chair of SC of ICT-XI, Montreal, CAN) Wallace Hayes (USA) Robert Hoffman (UK) Michel Holsapple (USA) Hoonjeong Kwon (KOR) Sameeh A. Mansour (Egypt) Manuel Repetto (E) Liliana Saldivar (Mexico) Kai Savolainen (F) Dieter Schrenk (D) Donna Seger (USA) Edda Villaamil (Argentine)

BARCELONAIUTOX 2010


5

International Advisory CommitteeMallé Jurima-Romet (President of the previous Congress) Silvia Barros (Brasil) (Developing Countries Committee)Richard D. Phillips (B)Nick Bateman (USA) AAJosé Castro (A(( rg)Guillermina Font (President AETOX)Corado Galli (President EUROTOX)Jyrki Liesivuori (President EUROTOX)Kai Savolainen (President IUTOX)

SOCIETIES COMMITTEES:

IUTOX Executive Committee

Spanish Association of Toxicology Committee

EUROTOX Executive Committee


6

Roche Diagnostics GmbHRoche Applied Science82372 Penzberg, Germany

Cell Viability and Cytotoxicity

Compound Profiling

Receptor-Mediated Signaling

Cell Invasion and Migration

Find out more about what is really going on with your cells and obtain data that end-point analysis could never realize.

For more information please visit www.xcelligence.roche.com

The xCELLigence SystemReal-Time Cell Analyzer Instruments More Cellular Analysis than Ever Before

Cross-sectional viewshowing 8 of the 16 wellsof the CIM-Plate 16(CIM = Cell Invasion &Migration).

Schematic representation of a single well of the CIM-Plate 16, showing (a) an upper chamber,(b) a membrane with an electrode sensor array engineered on the underside of the microporousmembrane (facing the lower chamber), and (c) a lower chamber.

Schematic representationof a single well of the CIM-Plate 16, with the migrated cells attached on the underside of the membrane.

For life science research only. Not for use in diagnostic procedures.XCELLigence is a trademark of Roche.CIM-PLATE, E-PLATE and ACEA BIOSCIENCES are registeredtrademarks of ACEA Biosciences, Inc. in the U.S.

© 2010 Roche Diagnostics GmbH. All rights reserved.

BARCELONAIUTOX 2010


7

VENUE

LEVEL 0

EXHIBITORSLUNCHCOFFEE BREAKPOSTER AREA

LEVEL 1

A- ROOM 13B- SECRETARIAT

LEVEL 2

C - ROOM 1D - ROOM 2 (SPEAKERS ROOM)E - ROOM 3F - ROOM 4G - ROOM 10

LEVEL 3

H- ROOM 5I- ROOM 6J- ROOM 7K- ROOM 8

A

F

KJ

I H

G

E

CD

B


8

General Summary TIMETABLE of the Congress

Monday 19 July Tuesday 20 July Wednesday 21 July

8:05 Subcommittees meetings Subcommittees meetings

EUROTOX Individual Member meeting ROOM 1

09:00 Registration(all day)

Bo Holmstedt Memorial Lecture Iam Kimber, GBR ROOM 7

ILSI-HESI Lecture Soterios Kyrtopoulos, GRK

10:00

10:00 Coffee Coffee / Sponsored by Ricerca Biosciences, LLC

10:30 Courses SY01 Toxicosurveillance- Current status and future prospects / ROOM 7

SY02 Sensory Systems as Toxicity Targets / ROOM 5

SY03 Safe Nanotechnologies - A Challenge for the Future / ROOM 6

SY04 The diet in colon cancer development / ROOM 13

SY09 Individual susceptibility to environmental and occupation exposure / ROOM 13

SY10 Endocrine disrupters: effects on reproduction and development / ROOM 6

SY11 Genotoxicity testing: for impurities in drugs / ROOM 7

SY12 Drugs of Abuse-The things you didn’t know / ROOM 5

Exhibitors prep.

13:00 Meetings

13:00

15:00

Poster Session 1Sub.Com-MeetingsExhibitionLunch

Poster Session 2EUROTOX Business Council Meeting ROOM 3ExhibitionLunch

15:00 (14:30-16:00) W1 EU Research Initiatives in Environment and Health (Sponsored by European Commission, Research DG) ROOM 13

13:00-14:00) W8 Informative Workshop on animal experimentation (Sponsored by AAALAC Internat.) ROOM 5

(14:30-16:00) W4 Informative Workshop. From Carcinogenicity to Metabolomic – Challenges in Regulatory Toxicology process (Sponsored by BASF) ROOM 5

(15:00-16:00) II Reunión de la Red Iberoamericana de Toxicología y Seguridad Química (RITSQ) ROOM 8

(15:00-16:00) W2 Round Table on publication in Toxicology (with the collaboration of Editors of Journals) ROOM 6

(14:30-16:00) W5 Informative Workshop. Label-Free Testing for Embryotoxicity, and Hepatic Cell and Cardiomyocyte Cytotoxicity(Sponsored by ROCHE) ROOM 6

16:00

(14:30-16:00) W3 Informative session about TRISK (European project on risk assessment training) ROOM 5

(14:00-15:00) W6 MARMOSET as model (Sponsored by RTC) ROOM 8

16:00 Coffee Coffee

16:30 SY05 Biomarkers and Molecular Mechanisms in Pesticide Toxicity /ROOM 7

SY06 Effects of climate change on human health - special focus on contaminants /ROOM 6

SY07 New Developments in Pulmonary Carcinogenesis / ROOM 13

SY08 Genetic polymorphism and drug metabolizing enzymes / ROOM 5

(18.30) Asamblea AETOX / ROOM 8

Award Lecture: ICTXII Early Toxicologist Award / ROOM 13

SY13 Risk Assessment of Herbal Medicines and Botanical Supplements (similar, but still different!) / ROOM 7

SY14 Glia-Neuron Interactions in Neurotoxicology / ROOM 5

SY15 Toxicity and risk assessment of heat-treatment formed products / ROOM 13

SY16 Integration of genomics, proteomics and metabolomics technologies in drug safety assessment / ROOM 6

18:00 Opening CeremonyAuditorium (R7)

Deichmann LectureManel Esteller. ESP

20:00 Welcome reception

BARCELONAIUTOX 2010


9

Thursday 22 July Friday 23 July

8:00 Subcommittees meetings Subcommittees meetings

09:00 EUROTOX-SOT Debate Sue Barlow, GBR, Michael Cheeseman, USA

Plenary LectureJose Vicente Castell. ESP

10:00

10:00 Coffee Coffee

10:30 SY17 Contribution of biological monitoring to occupational risk assessment / ROOM 6

SY18 Developmental Neurotoxicity Testing in the 21st Century: High-Throughput Screening Methods / ROOM 13

SY19 New trends in Food Safety / ROOM 5 Partly sponsored by European Food Safety Authority

SY20 In Silico Toxicology / ROOM 7 Sponsored by Prous Institute Biomedical Science

SY25 The changing face of clinical toxicology / ROOM 7 Sponsored by Bo Holmstedt Memorial Fund (BMHF)

SY26 Detoxication and susceptibility to anticholinesterase pesticides / ROOM 6

SY27 HBCD as a replacement flame etardant; another POP? / ROOM 5

SY28 Combined Exposures to Multiple Chemicals in Risk Assessment: A Pragmatic Approach / ROOM 13 Partly sponsored by WHO (World Health Organization) and EFSA (European Food Safety Authority)

13:00 Poster Session 3IUTOX General Assembly ROOM 3ExhibitionLunch

Final Conference (ECHA Lecture) / ROOM 3

Closing Ceremony / ROOM 3

15:00 (15:00-16:00) W8 Special REMA-ECOPA workshop on global effect and use of alternative methods under REACH (With the collaboration of REMA, ECOPA, ECVAM, ICVAM, JACVAM, COLIPA) ROOM 6

Accomplishments and Challenges in Global Chemicals Policy. Chair: Philip Wexler, US National Library of Medicine ROOM 13

16:00 Coffee

16:30 SY21 New insights into acetaminophen toxicity / ROOM 7

SY22 MicroRNA Malefactors: role in chemically-induced toxicity / ROOM 5 Sponsored by LRI - CEFIC (Long Ronge Research Initiative - The European Chemical Industry Council)

SY23 Education and chemical safety in developing countries / ROOM 6

SY24 Immunotoxicology: From models to humans / ROOM 13

20:30 Congress Dinner


10

SCIENTIFIC PROGRAM

19 July, MondayContinuous Educational Course

10:00-17:00 CEC-1 Individual susceptibility and biomarkers in occupational toxicology / ROOM 3 Chairs: Fernando Gil Antonio F. Hernández. Univ. Granada Development, validation and application of biomarkers in occupational toxicology Fernando Gil. Granada. Spain Biomarkers of exposure and susceptibility to pesticides and other xenobiotics Aristidis Tsatsakis and Vasilis Androutsopoulos. Greek

Ethical, legal and social concerns in the use of biomarkers in medical surveillance J.A. Lorente. Spain Role of genetic polymorphisms of xenobiotic-metabolising enzymes in occupational health. Relevance in occupational cancer Antonio F. Hernández. Granada. Spain

Biomonitoring for acute, occupational and low level exposures in risk assessment Jyrki Liesivuori. Finland

CYP450s phenotype-genotype correlations and potential workplace applications Elain Mutch. GBR

CEC-2 Regulatory toxicology and risk assessment processes for preventative and therapeutic vaccine development / ROOM 4 Chairs: Lawrence Segal. GSK Biologicals, Wavre. Belgium Sarah Gould. Sanofi Pasteur, Marcy L’Etoile. France Sponsored by Sanofi Pasteur and GSK Biologicals

Overview of global (FDA, EMEA, WHO, Japan) regulatory toxicology requirements for vaccines and immunostimulants Marion Gruber. US FDA, CBER, USA Yuansheng Sun. Paul-Ehrlich Institut, Federal Agency for Vaccines and Biomedicines. Germany Mineo Matsumoto. Office of Biologics, PMDA. Japan

Single dose, local tolerance, repeated dose, safety pharmacology, biodistribution and integration study designs for vaccines Roy Forster. CIT, Evreux. France

Reproductive toxicity and fertility study designs for vaccines Paul Barrow. Ricera Biosciences, Saint Germain sur l’Arbresle. France

Hypersensitivity and autoimmunity Marc Pallardy. INSERM 996, Faculte de Pharmacie, Universite de Paris-Sud 11. France

Environmental Assessment of GMO vaccine antigens and the safety evaluation of residuals, contaminants, and extractables/leachables André Penninks. TNO. Netherlands

BARCELONAIUTOX 2010


11

CEC-3 In vitro test of teratogenicity: a practical approach Chairs: Marta Barenys. GRET-CERETOX group, Toxicology Unit, School of Pharmacy, Public Health Department, University of Barcelona Joaquín de Lapuente. GRET-CERETOX group, Experimental Toxicology and Ecotoxicology Unit, Barcelona Science Park Organized by GRET CERETOX (UB/PCB)

Course localization: School of Pharmacy, University of Barcelona (Building B, Classroom B-205) Av. Joan XXIII s/n. Barcelona. 08028

Teratogeny and embryotoxicity: state of the art Miquel Borràs

Teratogeny preliminary evaluation. In vitro screening tests Burkhard Flick

Practical session I: Whole Embryo Culture and Fish Embryo Test with Zebrafish Elisabet Teixidó, Núria Boix, Burkhard Flick and Marta Barenys

Practical session II: Micromass test and Embryonic Stem Cell Test Lydia Camps, David Ramos, Javier González-Linares and Joaquín de Lapuente

CEC-4 Evaluation of drugs without animals Chairs: Domingo Gargallo. Ferrer International. Toxicology and Safety Pharmacology Barcelona. Spain Joan Albert Vericat. Noscira, Madrid. Spain With the collaboration of REMA (The Spanish Network of Alternative Methods)

Course localization Ferrer International

Objective: Review the different possibilities today available to reduce the attrition rate during regulatory non-clinical and clinical development. Is there enough information available in early screening to conduct a limited safety assessment? Until which degree animals can be removed from non-clinical development?

Lecture 1: Introduction I: The Regulatory Frame in Non-Clinical Drug: Genetic Toxicology Early Screening Esperanza Herreros and Santiago Ferrer. In vitro Toxicity and Toxicity, GSK. Madrid Lecture 2: Introduction II: The concept of the 3Rs+R2 (= Replacement, Refinement, Reduction + Responsibility in Research); attrition rates and overview of existing non-animal approaches Joan Albert Vericat. Noscira, Madrid. Spain Lecture 3: Genetic Toxicology Early Screening (30+10 minutes) Domingo Gargallo. Ferrer International, Barcelona. Spain Lecture 4: Metabolism & ADE; (1) Metabolism. (2) ADE & Modeling Lourdes Gombau. Avancel. Barcelona, José Vicente Castell. Centro Investigacion, Hospital La Fe, Valencia. Spain Lecture 5: Need for complexity: Integration in vitro and in vivo activities Joan Albert Vericat. Noscira, Madrid. Spain Lecture 6: Points of view of Regulatory Authorities Federico Goodsaid. US-FDA. Pending confirmation Final Discussion: Open discussion and take home messages


12

CEC-6 Online Internet sources of toxicological information: a practical course palmtop computer with wifi is needed)

Course localization: School of Pharmacy, University of Barcelona (Building B) Av. Joan XXIII s/n. Barcelona. 08028

Objective: Toxicology Information Online: A Practical Course on Web-based Resources Instructors: Guillermo Repetto. Universidad Pablo de Olavide. Sevilla. Spain Philip Wexler. Toxicology and Environmental Health Information Program, National Library of Medicine. USA Agenda:

1. Introduction & NLM Toxicology Information Resources 2. Practical Exercises Searching NLM Resources 3. Other Toxicology Information Resources (e.g. from US EPA, NIEHS, Spanish resources etc.) 4. Practical Exercises Searching Other Resources 5. Consolidating Resources (e.g. ECHA, ESIS, BuscaTox, eChemPortal, World Library) 6. Practical Exercises Searching Consolidating Resources; Questions; Wrap-Up

CEC-7 Animal and in vitro models for the assessment of sensory and nervous toxicities Animal models for neurotoxicity screening, and for auditory and vestibular assessment / ROOM 8 Chair: Jordi Llorens. PhD, Universitat de Barcelona. ESP

Donald A. Fox, PhD, University of Houston (USA). Assessment of retinal and visual system toxicity Cristina Suñol. PhD, Consejo Superior de Investigaciones Científicas. ESP

Neuronal culture methods in toxicity assessment Kevin M. Crofton. PhD, United States Environmental Protection Agency. Screening for developmental neurotoxicity Anna K. Price. PhD, European Commission Joint Research Centre (Italy). Gene expression as a tool for neurotoxicity assessment

18:00 Opening Ceremony / ROOM 7 Chairs: Arturo Anadón. Complutense University, Madrid. ESP Kai Savolainen. Finnish Institute of Occupational Health, Helsinki. FIN

KL01 Opening Deichmann Lecture Epigenetics: The Last Frontier Beyond Genetics Manel Esteller. Director of the Cancer Epigenetics and Biology Program. Bellvitge Institute for Biomedical Research (IDIBELL), Barcelona. ESP

20.00 Welcome Reception (in the exhibition Area)

BARCELONAIUTOX 2010


13

20 July, Tuesday09.00 KL02 Bo Holmsted Memorial Lecture / ROOM 7 Chairs: Herman Autrup. Aarhus University. Denmark. DNK Corrado Galli. University of Milan. IT KL02 Chemical and Protein Allergy: Progress, Opportunities and Challenges Iam Kimber. Faculty Life Sciences. University of Manchester. GBR

10:00-10:30 Coffe break (in Exhibition Area)

10:30 SY01 Toxicosurveillance- Current status and future prospects / ROOM 7 Chairs: Nickholas Bateman. University of Edinburgh. GBR Hermann Bolt. IfaDO, Dortmund. DEU

SY01-1 Toxicosurveillance Spanish Program Ana Ferrer-Dufol. Unit of Clinical Toxicology. Clinical Hospital, Zaragoza. ESP SY01-2 Practical approaches to toxicosurveillance in Asia Andrew Dawson. Faculty of Medicine, University of Peradeniya, Peradeniya. SRI SY01-3 Using epidemiological data to study lethal occupational exposures David Coggon. MRC. Epidemiology Resource Centre, University of Southampton. GBR SY01-4 Toxicosurveillance using poison center data-streams Salome Ballesteros. Servicio Informacion Toxicológica, Madrid.ESP SY01-5 International collaboration in Toxicosurveillance: a WHO perspective Tim J Meredith. International Programme on Chemical Safety. World Health Organization, Geneva. CHE

10:30 SY02 Sensory Systems as Toxicity Targets / ROOM 5 Chairs: Larry Fechter. Jerry Pettis Memorial Veterans Medical Center. USA Werner Kobel. ToxAdvice GmbH. SWI SY02-1 Can the synergistic effects of a combined exposure to noise and solvents be explained through the pharmacological effects of solvents on the central nervous system? Pierre Campo. Institut National de Recherche et de Sécurité. FR SY02-2 Toxicity of Nitriles on the Peripheral Vestibular System: Defining New Families of Compounds with “Classic-Type” of Inner Ear Toxicity Jordi Llorens. Universitat de Barcelona. ESP SY02-3 Visual Effects of Exposure to Volatile Organic Solvents in an Animal Model William K. Boyes. US Environmental Protection Agency. USA SY02-4 Chemosensory Effects of Exposure to Volatile Organic Compounds in Humans Christoph van Thriel. Leibniz Research Centre for Working Environment and Human Factors at the University of Dortmund. DEU SY02-5 Chemical exposure as a risk factor for hearing loss: implications for occupational health Ann-Christin Johnson. Karolisnka Institute. SWE


14

10:30 SY03 Safe Nanotechnologies - A Challenge for the Future / ROOM 6 Chairs: Kai Savolainen. Finnish Institute of Occupational Health, Helsinki. FIN Liliana Saldivar. Universidad Nacional Autónoma de México. MEX

SY03-1 New Lessons of Safety Challenges of Engineered Nanoparticles - Introduction Kai Savolainen. Finnish Institute of Occupational Health, Helsinki. FIN SY03-4 Assessment of Exposure to Nanoparticles in Occupational Setting Gerhard Kasper. Institut für Mechanische Verfahrenstechnik und Mechanik. University of Karlsruhe. DEU SY03-2 Causality of Exposure to Engineered Nanoparticles and Their Bio logical Effects Allison Elder. School of Medicine & Dentistry, University of Rochester, Rochester. NY. USA SY03-5 Carbon Nanotubes - Challenges for Assuring Safety of Nanotechnologies Ken Donaldson. MRC Centre for Inflammation Research (CIR). University of Edinburgh. GBR SY03-3 Nanotoxicology: Biological effects of manufactured nanoparticles and their health Yuliang Zhao. Institute of High Energy Physcs. Chinese Academy of Science Beijing. CHN

10:30 SY04 The diet in colon cancer development / ROOM 13 Chairs: Dieter Schrenk. Universitat. Kaiserslautern. DEU Pablo Steinberg. University of Veterinary Medicine Hannover. DEU SY04-1 In vitro models to study diet-related colon cancer induction and prevention Jenifer I. Fenton. Department of Food Science and Human Nutrition, Michigan State University. USA SY04-2 Red and processed meat intake and risk of colorectal adenoma and carcinoma from a molecular epidemiological point of view Rashmi Sinha. Division of Cancer Epidemiology and Genetics, National Cancer Institute. USA SY04-3 The role of folate in colon cancer development Robert Clarke. Clinical Trial Service Unit, University of Oxford. GBR SY04-4 The role of flat dysplastic aberrant crypt foci induced in the colon by food contaminants Jan Alexander. Division of Environmental Medicine, Norwegian Institute o Public Health. NOR SY09-5 The role of inflammation in colon cancer induced by food contaminants Pablo Steinberg. Institute for Food Toxicology and Analytical Chemistry University of Veterinary Medicine Hannover. DEU

13:00 -14:30 SY04 Lunch (in Exhibition Area)

BARCELONAIUTOX 2010


15

13:00-16:00 P1 Poster Sessions day 1 (14:00-15:00) Author present P101 - HUMAN BIOMONITORING P102 - EPIDEMIOLOGICAL TOXICOLOGY P103 - ENVIRONMENTAL HEALTH P104 - OCCUPATIONAL TOXICOLOGY P105 - HUMAN CLINICAL TOXICOLOGY P106 - REGULATORY AND RISK ASSESSMENT P107 - METABOLISM/ BIOTRANSFORMATION /POLYMORPHISMS P108 - ECOTOXICOLOGY

14:30 W1 EU Research Initiatives in Environment and Health / ROOM 13 Chair: Tuomo Karjalainen. Scientific Officer. European Commission Sponsored by the European Commission

14:30 W1-1 Introduction: European Union support for research on environment and health issues Tuomo Karjalainen. European Commission, Research Directorate-General

14:45 W1-2 Cancer and the environment: Experience from the EU-funded ENVIROGENOMARKERS, NEWGENERIS and ECNIS projects Soterios Kyrtopoulos. National Hellenic Research Foundation. Greece

15:00 W1-3 Exposure to nanomaterials and possible impacts: Experience from the EU-funded NANODEVICE. NANOIMPACTNET and HINAMOX projects Kai Savolainen. Finnish Institute of Occupational Health

15:15 W1-4 Mixture toxicity of chemicals: Experience from the EU-funded CREDO and NECTAR clusters of projects Andreas Kortenkamp. University of London School of Pharmacy

15:30 W1-5 Access to EU funding, project types, priorities, application process, national funding, availability of information etc… Panel discussion of all speakers

16:00 W1-6 Closure Tuomo Karjalainen. European Commission, Research Directorate-General

15:00 W2 Round Table on “Publication in Toxicology” / ROOM 6 Chair: Hermann Bolt. IfaDO. Dortmund. DEU With the collaboration of journal Editors

Participants: Allan Boobis. Food Chem Toxicol Walgang Dekant. Toxicol Letters Jan G Hengstler. Arch Toxicol Roger O McClellan. Crit Rev Toxicol Philip Wexler. NIH/NLM Issues for discussion: Changes and trends in scientific publications. Development of quality, preferred areas for publication. Publication in toxicology journals versus information of toxicology in databases and in non-toxicology journals. Submission versus reviewing expertise. The pressure to publish. Future of bibliometrics. Changing publication behaviours.


16

14:30 W3 TRISK. Risk Assessor training: ensuring availability of highly qualified professionals (Informative session) Chair: Corrado Galli and Takis Daskaleros. TRISK project

Welcome & General Overview of TRISK Corrado L. Galli

Fundamentals and key aspects of TRISK Emanuela Corsini

Benefits of European Risk Assessment Accreditation Helen Hakansson

Lessons learnt of risk assessment training Carmen Estevan (TRISK trainee)

The reaction of industry stakeholders Giuseppe Malinverno

EFSA Journal: a source of high quality risk assessments Carola Sondermann

15:00-16:00 II REUNIÓN DE LA RED IBEROAMERICANA DE TOXICOLOGÍA Y SEGURIDAD QUÍMICA (RITSQ) / ROOM 8 Coordinador/Chair: Eduardo de la Peña de Torrres. Consejo Superior de Investigaciones Científicas. España

Participantes/Participants: 1. Silvia Barros. Universidad de Sáo Paulo. Brasil 2. Gerardo D. Castro. CITEFA. Argentina 3. Raquel Alarcón. Universidad de Almería. España 4. Liliana Saldivar. Universidad Nacional de México 5. Guillermo Repetto. Universidad San Pablo de Olavide. España 6. Myrian Gutierrez, Nancy Patiño. Universidad Nacional de Colombia 7. Patricia Escalante Galindo, Centro Toxicológico, Hospital Juárez de México 8. Mª Carmen Riva. (CRIT) Universidad Politécnica de Cataluña. España 9. Araceli Pillco. Universidad Mayor de San Andrés. Bolivia 10. Nelly Mañay. Universidad de la República de Uruguay 11. Carlos Augusto Mello-da-Silva. Centro de Informaçao Toxicológica.Brasil 12. Mª Fernanda Cavieres. Universidad de Valparaiso. Chile 13. Eugenio Vilanova. Universidad de Alicante. España 14. Manuel Repetto. Magister Internacional en Toxicología Colegio Oficial de Químicos de Sevilla. España 15. Guillermina Font. Universidad de Valencia. España

The aim of this meeting is to present the existing collaborating activities and agreements. To Discuss about future coordinated plans with Iberoamerica on formation as well as on research: It is an open meeting and any concern or suggestion on the RITSQ will be more than welcome.

El objetivo de la reunión es exponer las actividades, y convenios de colaboración existentes. Dialogar sobre la planificación de futuras colaboraciones con Iberoamérica tanto de formación como en investigación. La reunión es abierta y cualquier inquietud o sugerencia sobre la RITSQ será bienvenida.

BARCELONAIUTOX 2010


17


16:30 SY05 Biomarkers and Molecular Mechanisms in Pesticide Toxicity / ROOM 7 Chairs: Arturo Anadón. Complutense University. Madrid. SPN Sameeh A. Mansour. National Research Centre. EGP SY05-1 In Vivo Biomarkers of Neurotoxicity Induced by Organophosphates and Carbamates Ramesh C. Gupta. Murray State University. USA SY05-2 Plasma ß-glucuronidase as an alternative biomarker to cholinesterase for organophosphate exposure Tetsuo Satoh. Chiba University. JPN SY05-3 Application of biomarkers of exposure, effect and susceptibility to subjects long-term exposed to pesticides Antonio F. Hernández. University of Granada School of Medicine, Granada. ESP SY05-4 Effects of organophosphate exposure on male reproductive outcomes B. Quintanilla-Vega. Departamento de Toxicología, CINVESTAV, Zacatenco, Mexico DF. MEX

16:30 SY06 Effects of climate change on human health - special focus on contaminants / ROOM 6 Chairs: Arja Rautio. University of Oulu. FIN José Mª Llobet. Universidad de Barcelona. ESP

SY06-1 Climate change, contaminant and Alaska native health James E. Berner. Alaska Native Tribal Health Consortium, Anchorage, Alaska. USA SY06-4 Climate change, contaminants and human health in Arctic Russia Valery P. Chaschin. Mechnikov Medical Academy, Moscow. RUS SY06-2 Human health in the context of changing ecosystems and environment Arja Rautio. University of Oulu. FIN SY06-3 The North - South dimension –are the effects of climate change equal in the South and North? Jon Oving Odland. University of Tromso. NOR SY06-5 The environmental health and contaminants in South Africa Halina. B. Röllin. South African Medical Research Council (abstract in P308-047)


18

16:30 SY07 New Developments in Pulmonary Carcinogenesis / ROOM 13 Chairs: Heidi Foth. University of Halle, Germany (GT). DEU Lewis Smith. Syngenta. UK

SY07-1 Deregulated EGFR Signaling during Lung Cancer Progression Adi Gazdar. University of Texas Southwestern Medical Center, Dallas. USA SY07-2 Pattern of in vitro stress response of lung cells from lung cancer cases Heidi Foth. University of Halle, Germany (President of the German Society of Toxicology (GT). DEU SY07-3 Transgenic and Smoke-Induced Rodent Lung Cancer Models Hans-Juergen Haussmann. Toxicology Consultant, Roesrath. DEU SY07-4 Changes of the genome DNA methylation in the progress of benzo[a]pyrene-induced transformation Zhixiong Zhuang. ShenZhen Center for Disease Control and Prevention. CHI (Short communication) (poster in P203-030)

16:30 SY08 Genetic polymorphism and drug metabolizing enzymes / ROOM 5 Chairs: Edmund Maser. Institute of Toxicology and Pharmacology, Univ. Med. School Schleswig-Holstein, Kiel. DEU María Aránzazu Martínez. Universidad Complutense de Madrid. ESP

SY08-2 Carbonyl Reductases/Steroid Dehydrogenases: Biology, Classification and Implication in Drug Metabolism and Detoxification Edmund Maser. Institute of Toxicology and Pharmacology, Univ. Med. Sch. Schleswig-Holstein, Kiel. DEU SY08-3 Metabolic activation of PAHs by aldo-keto reductases Trevor M. Penning. Philadelphia. USA SY08-4 Epoxide hydrolases: structure, function, mechanism and toxicological implication Michael Arand. Zurich. CHE SY08-5 Urinary 1-OHP levels in children are modulated by cyp1a1*2c, cyp1b1*3, gstm1*0 and nqo1*2 polymorphisms M. Sánchez-Guerra. CINVESTAV-IPN, México (Short communication) (poster in P107-006)

18:30 Asamblea AETOX

BARCELONAIUTOX 2010


19

21 July, Wednesday8:00 Eurotox Individual Member Meeting / ROOM 1

9:00 KL03 ILSI-HESI Lecture / ROOM 7 Chairs: Liesivuori Jyrki. Finnish Institute of Occupational Health, Turku. FI Michael P. Holsapple. ILSI Health and Environmental Sciences Institute. Washington. USA

KL03 Mechanism-based environmental health research in the age of genomics Soterios Kyrtopoulos. National Hellenic Research Foundation. GRC

10:00-10:30 Coffe break (in Exhibition Area) Sponsored by Ricerca Biosciences, LLC

10:30 SY09 Individual susceptibility to environmental and occupation exposure / ROOM 13 Chairs: Nursen Basaran. Hacettepe University Faculty of Pharmacy, Ankara. TR Ruth Roberts. AstraZeneca, UK. GBR

SY09-1 Effect of genetic and environmental factors on biomarkers of exposure Hermann Autrup. Univ. of Aarhus, Aarhus, Denmark. DNK

SY09-2 Modulation of arseniasis risk by host factors in a multiethnic village Jian-Hua Shen. Shanghai Institutes of Biological Sciences, Chinese Acad.Sc., Shanghai. CHN SY09-3 Human bladder cancer and individual susceptibility factors Miriam Angeli-Greaves. Univ. of Vernezuela, Caracas, Venezuela. VEN

SY09-5 Application of DNA-chip based techniques in occupational studies Jan G. Hengstler. IfADo. Dortmund, Germany. DEU SY09-4 Factors of individual susceptibility to benzene: state of the art Robert Snyder. EOHSI, Rutgers University, Piscataway, NJ. USA


20

10:30 SY10 Endocrine disrupters: effects on reproduction and development / ROOM 6 Chairs: Anunciación Lafuente. Lab. of Toxicology, University of Vigo. ESP Elaine Faustman. Institute for Risk Analysis & Risk Communicationreceives, WA. USA

SY10-1 Steroid hormone receptors and metabolism in endocrine disruption Sari Mäkelä. Functional Foods Forum. University of Turku. FIN

SY10-2 Retinoid receptors and metabolism in endocrine disruption Helen Håkansson. The Institute of Environmental Medicine, Karolinska Institute, Stockholm. SWE

SY10-3 Reprogramming of DNA methylation during mammalian development and impact of Endocrine Disruptors Michael Weber. Institute of Molecular Genetics CNRS. FRA

SY10-4 Criteria for the interpretation of reproductive and endocrine effects detected in regulatory guideline studies Roland Solecki. Bfr, Berlin. DEU

SY10-5 Delineation of Persistent Organic Pollutant effects in human: cellular and clinical studies Robert Barouki. Université René Descartes. Paris. FRA

10:30 SY11 Genotoxicity testing: for impurities in drugs / ROOM 7 Chairs: Ricard Marcos. Autonomous University of Barcelona. ESP Bárbara Hales. McGill University. Canada

SY11-1 Genotoxicity assessment in early drug development: identification, new models and strategies Jacky Van Gompel. Genotoxicology and in vitro toxicology of J&J Pharma. BEL

SY11-2 Genotoxicological qualification of impurities in the pharmaceutical industry Michelle Kenyon. Genotoxicologist at Pfizer, Groton. USA SY11-3 Genotoxicity testing of pharmaceuticals: An update on changing regulatory guidances Peter Kasper. German Regulatory Agency Bfarm. DEU

SY11-4 Future approaches to genotoxicity testing for drugs and impurities David Tweats. Genetic toxicology, Sweansea University, Wales. GBR

SY11-5 Threshold for Toxicological Concern (TTC) and impurities Lutz Müller. Hoffmann-La Roche, Basel. CHE

BARCELONAIUTOX 2010


21

10:30 SY12 Drugs of Abuse-The things you didn’t know / ROOM 5 Chairs: Donna Seger. Dept Pharmacol & Toxicol, University of Oulu. FIN Alexander Buerkle. University of Konstanz. DEU

SY12-1 Cocaine-Why so Lethal? Robert Hoffman. New York City Poison Control Center. USA

SY12-2 Cannabis acute and chronic effects-The Dutch Experience Irma de Vries. National Poisons Information Centre, Bilthoven. NLD

SY12-3 GHB and other submission agents. Clinical and legal implications Santiago Nogué. Unit of Clinical Toxicology. Clinic Hospital Barcelona. ESP

SY12-4 Neuroadaptation and Drugs of Abuse or How Drugs Change your Brain Donna Seger. Vanderbilt University Medical Center. Nashville TN. USA

SY12-5 New emerging designer drugs Paul Dargan. Guy’s and St. Thomas Poisons Unit. London. GBR

13:00-14:30 Lunch (in Exhibition Area)

13:00 - 17:30 Eurotox Business Council Meeting

13:00- 16:00 P2 Poster Sessions day 2 (14:00-15:00) Author present

P201 - IN VITRO TESTING METHODS P202 - MUTAGENICITY-GENOTOXICITY P203 - CARCINOGENICITY P204 - REPRODUCTION AND DEVELOPMENT P205 - INMUNOTOXICITY P206 - TARGET ORGAN TOXICITY: HEPATOTOXICITY P207 - TARGET ORGAN TOXICITY: NEUROTOXICITY P208 - TARGET ORGAN TOXICITY: OTHER

13:00-14:00 W4 The laboratory animal : a key player in toxicological sciences / ROOM 5 Chair: Javier Guillén. Senior Director and Director of European Activities. AAALAC International Sponsored by Association for Assessment and Accreditation of Laboratory Animal Care, AAALAC International AAALAC International: quality science and animal welfare together in an accreditation scheme Javier Guillén. Senior Director and Director of European Activities. AAALAC International Benefits in Toxicology from peer reviews of animal care and use programs Peter Clausing. Senior Toxicologist. Council on Accreditation AAALAC International

14.00 The MARMOSET as a model for the evaluation of novel pharmaceuticals and biotechnology - derived products / ROOM 8 Sponsored by RTC


22

14:30-16:00 W4 Informative Workshop Fron Carcinogenicity to Metabolomic – Challances in Regulatory Toxicology process / ROOM 6 Sponsored by BASF 1. Metabolomics: A tool for early identification of toxicological effects and an opportunity for biology based chemical grouping under REACH Bennard van Ravenzwaay

2. Mode of action: CAR-mediated rodent-specific hepatocarcinogenicity Naveed Honarvar

3. Pathology Working Group: A scientific solution for conflicting pathological datasets Sibylle Gröters

14:30-16:00 W5 Label-Free Testing for Embryotoxicity, and Hepatic Cell and Cardiomyocyte Cytotoxicity / ROOM 6 Sponsored by ROCHE Identification of embryotoxic effects of the marine biotoxin okadaic acid using different murine embryonic stem cells Alfonso Lampen. Department Food Safety. Federal Institute for Risx Assessment. Berlin

Screening of Cardiotoxic and Pro-Ayythmic Compounds Using Stem Cell-Derived Cardiomyocytes with the xCELLigence RTCA Cardio System Yama A. Abassi. ACEA, Cell Biology and Assay Development


16:30 SY13 Risk Assessment of Herbal Medicines and Botanical Supplements (similar, but still different!) / ROOM 7 Chairs: Mumtaz Iscan. Faculty of Pharmacy, Ankara University. TR Manuel Repetto. Magister Internacional en Toxiclología Colegio. ESP

SY13-1 Herbals and botanicals in the grey area between medicines and nutrition: scientific and regulatory challenges Gert Laekeman. Katolieke Universiteit Leuven. Leuven. BEL

SY13-2 A huge number of mixtures and substances: how to deal with them? Mª da Graça Campos. Faculty of Pharmacy. Universidade de Coimbra Azinhaga de Sta Comba Coimbra. Portugal SY13-3 Standardized Evaluation of TCM drug safety and its safe use in China Zu-Guang Ye. State Research Center for R&D of TCM Multiingredient drug. Chinese Academy of TCM. Beijing. CHN SY13-4 Compability risks between drugs and herbal medicines or botanical supplements Ashim K. Mitra. School of Pharmacy. University of Missouri-Kansas City. USA

BARCELONAIUTOX 2010


23

16:30 SY14 Glia-Neuron Interactions in Neurotoxicology / ROOM 5 Chairs: Marina Guizzetti. University of Washington, Seattle, WA. USA Hoonjeong Kwon. Seoul National University. Korea

SY14-1 Proinflammatory cytokines, glutamatergic system and neurotoxicity Barbara Viviani. Universita’ degli Studi di Milano. ITA

SY14-2 Ethanol activates IL-1RI/TLR4 in glial cells and induces neuroinflammation Consuelo Guerri. Centro de Investigación Príncipe Felipe, Valencia. ESP SY14-3 Chaperone deficiency in Pb-exposed glia: links to neurodegenerative diseases Evelyn Tiffany-Castiglioni. Texas A&M University. College Station TX. USA

SY14-4 Fetal Alcohol Spectrum Disorders: inhibition of astrocyte release of extracellular matrix proteins and neuritogenesis Marina Guizzetti. University of Washington, Seattle, WA. USA

16:30 Award Lecture: ICTXII Early Toxicologist Award / ROOM 13 Chair: Daniel Acosta. IUTOX President-Elect AWL Venom induced consumption coagulopathy – understanding an important manifestation of snake envenoming Geoff K. Isbister. University of Newcastle and Department of Clinical Toxicology and Pharmacology, New South Wales. Australia

17:00 SY15 Toxicity and risk assessment of heat-treatment formed products / ROOM 13 Chairs: Wolfgang Dekant. Department of Toxicology, University of Würzburg. DEU María José Ruiz. Universidad de Valencia, ESP

SY15-1 Heat-treatment induced toxicant in food: Needs for health risk assessment Wolfgang Dekant. Department of Toxicology, University of Würzburg. DEU SY15-3 Role of genetic and epigenetic mechanisms in furan toxicity Kevin Chipman. University of Birmingham. GBR SY15-2 Risk assessment of chemicals formed by heat processing of food Angelika Tritscher. WHO Joint Secretary to JECFA and JMPR, Geneva. WHO


24

16:30 SY16 Integration of genomics, proteomics and metabolomics technologies in drug safety assessment / ROOM 6 Chairs: Joan-Albert Vericat. Noscira, Madrid. ESP Yoko Hirabayashi. National Institute of Health Sciences. JPN

SY16-2 Integration of genomics, proteomics and metabolomics technologies in drug safety assessment: the need for collaboration and external funding Phil Hewitt. Merck KGaA, Darmstadt. DEU

SY16-1 Integration of X-Omics data in the decision making process in Drug Development. The Melius Consortium Joan Vericat. Noscira, Madrid. ESP

SY16-4 EMEA’s position in the use of X-Omics in regulatory studies Dominiqe Masset. Toxicology Department, DEMEB. FRA

SY16-3 The use of X-Omics in regulatory studies Federico Goodsaid. U.S. FDA. Silver Spring MD. USA

BARCELONAIUTOX 2010


25

22 July, Thursday09:00 DEB01 EUROTOX-SOT Debate / ROOM 7 Threshold of Toxicological concern(TTC): is based on science or politics? Chairs: Nancy Claude. Institut de Recherches Internationales Servier. Courbevoie. FRA Jon C. Cook. SOT, Pfizer, INC, Groton, CT. USA Sponsored by EUROTOX and Society of Toxicology USA

Deb-1 IN FAVOUR: Sue Barlow. Independent Consultant in Toxicology, Brighton. GBR

Deb-2 AGAINST: Michael Cheeseman. Center for Food Safety and Applied Nutrition, US FDA, College Park, MD. USA


10:30 SY17 Contribution of biological monitoring to occupational risk assessment / ROOM 6 Chairs: Maurizio Manno. University of Naples Federico II. ITA Aristidis Tsatsakis. University of Crete. Greece

SY17-1 Biomonitoring for occupational health risk assessment (BOHRA): the ICOH-SCOT approach Maurizio Manno. University of Naples Federico II. ITA

SY17-2 Toxicokinetic considerations in using a suite of markers to better understand occupational health risk from PAH exposure Claude Viau. University of Montreal. CAN

SY17-3 Non-invasive biomonitoring for carcinogen DNA adducts: practical application of basic toxicology Glenn Talaska. University of Cincinnati. USA

SY17-4 Saliva and axillary hair as non-invasive samples in the biomonitoring of workers exposed to metal ions and other chemicals Fernando Gil. University of Granada, Occupational Health School. Granada. ESP

SY17-5 The contribution of molecular biology to the biological monitoring of human exposure to chemicals Arnulfo Albores. CINVESTAV. MEX


26

10:30 SY18 Developmental Neurotoxicity Testing in the 21st Century: High-Throughput Screening Methods / ROOM 13 Chairs: Donald A. Fox. University of Houston. USA Guillermo Repetto. Universidad San Pablo de Olavide. ESP

SY18-1 Screening for Developmental Neurotoxicity: Past and Future Kevin M. Crofton. US Environmental Protection Agency. USA

SY18-2 Cell-based in vitro Screening Methods for Developmental Neurotoxicity Cristina Suñol. Institut d’Investigacions Biomèdiques de Barcelona. CSIC-IDIBAPS. CIBER Epidemiología y Salud Pública, Barcelona. ESP

SY18-4 Human neurospheres as three-dimensional cellular systems for developmental neurotoxicity testing Ellen Fritsche. Institut für umweltmedizinische Forschung gGmbH, Düsseldorf. DEU

SY18-5 Present state analysis and policy direction of high-throughput, methods for de velopmental neurotoxicity Ryozo Tsuji. Sumitomo Chemical. JPN

10:30 SY19 New trends in Food Safety / ROOM 5 Chairs: Jolanta Gromadzinska. Nofer Institute of occupational. Lod 2. POL Guillermina Font. University of Valencia. ESP Partly sponsored by European Food Safety Authority

SY19-1 Chemical risk assessment : Historical perspectives and current trends Jean Lou Dorne. European Food Safety Authority Parma. ITA

SY19-2 Molecular mechanistic basis for risk assessment of biotoxins in foods Edmond Creppy. University Bordeaux 2. Toxicology. FRA SY19-3 Mycotoxicological risks of main European food/feed chains Antonio F. Logrieco. Institute of Sciences of Food Production Research. ITA

SY19-4 Protective effect of antioxidants against mycotoxins induced citotoxicity in cells Maria José Ruiz. Facultad de Farmacia, Universidad de Valencia. ESP

SY19-5 Pesticide risk assessment at the European Food Safety Authority: New developments L. Mohimont. European Food Safety Authority, Parma. ITA

BARCELONAIUTOX 2010


27

10:30 SY20 In Silico Toxicology / ROOM 7 Chairs: Luis G. Valerio. US Food and Drug Administration. USA Giuseppe Malinverno. Solvay SA. Belgium Sponsored by Prous Institute Biomedical Science

SY20-1 Role of the European Commission’s Joint Research Centre in Computational Toxicology Andrew Worth. European Commission – Joint Research Centre, Ispra. EUR

SY20-2 BioEpisteme – an in silico approach to predict and understand the underlying molecular mechanisms contributing to toxicity responses Antoni Valencia. Prous Institute for Biomedical Research, Barcelona. ESP

SY20-3 A knowledge-based approach to the in silico assessment of toxicity Carol A. Marchant. Lhasa Limited. GBR

SY20-4 In silico toxicology: predictive methods and applied regulatory research at the US FDA Center for Drug Evaluation and Research Luis G. Valerio. US FDA. USA

SY20-5 In silico approaches, and in vitro and in vivo mutagenicity assays: implications for regulatory issues Romualdo Benigni. Istituto Superiore di Sanita. ITA

13:00-14:30 Lunch (in Exhibition Area)

13:00-17:30 IUTOX General Assembly

13:00-16:00 P3 Poster Session day 3 (14:00-15:00 Author present) P301 - COSMETICS P302- DRUGS DEVELOPMENT P303 - NANOTOXICOLOGY P304 - INDUSTRIAL CONTAMINANTS P305 - FORENSIC TOXICOLOGY P306 - ANALYTICAL TOXICOLOGY P308 - METALS P309 - PESTICIDES P310 - FOOD SAFETY P311 - BIOTOXINS P312 - EDUCATIONAL-TRAINING-PUBLICATION- SOCIAL ASPECTS P313 - MISCELANEOUS

14:30-16:00 W7 Global impact of 3’Rs on regulatory processes: sharing experiences and future trends / ROOM 6 Chair: Argelia Castaño. REMA President, I. S. Carlos III, Madrid. SPAIN Organised by REMA (Spanish Platform on Alternatives) with the participation of experts from REMA, ECOPA, ECVAM, JACVAM, CAAT, BASF, Ferrer International Adela López Cerain. ECOPA President, Universidad de Navarra Hajime Kojima. JaCVAM Thomas Hartung. CAAT Domingo Gargallo. Toxycology and Safety Pharmacology. Ferrer International. Robert Landsiedel. BASF Product Safety - Experimental Toxicology and Ecology


28

14:30-16:00 W8 Accomplishments and Challenges in Global Chemicals Policy / ROOM 5 Chair: Philip Wexler. US National Library of Medicine. USA With the collaboration of experts from the US NLM, UN, WHO OECD, OpenTox and Eco Conseil Advancing toxicology through a more strategic approach to international chemicals management Lesley Onyon. United Nations Environment Programme Carolyn Vickers. World Health Organization A European Chemicals Agency Perspective David Bell. European Chemicals Agency (ECHA)

Satisfying REACH Requirements in Predictive Toxicology Barry Hardy. OpenTox Project Coordinator OECD Chemicals Programme and Test Guidelines Laurence Musset. Test Guidelines Programme. OECD Hitoshi Someya. Environment Directorate. OECD

Globally Harmonised System for Classification and Labeling Jan van der Kolk. Eco Conseil

16:00-16:30 Coffee break (in Exhibiton Area)

16:30 SY21 New insights into acetaminophen toxicity / ROOM 7 Chairs: Ana Ferrer-Dufol. Unit of Clinical Toxicology. Clinical Hospital. Zaragoza. ESP Jack Hinson. Division of Toxicology, Univ Arkansas. USA

SY21-1 New insights into the mechanisms of acetaminophen toxicity Jack A. Hinson. Division of Toxicology, Univ Arkansas. USA

SY21-4 Toxicity of acetaminophen in therapeutic doses Paul B. Watkins. University of North Carolina, Chapel Hill, NC. USA SY21-5 Identification of patients at risk of hepatotoxicity Marco Sivilotti. Department of Emergency Medicine, Queen’s UniversityKingston, Ontario. CAN

SY21-2 Identification of patients at risk of adverse effects from acetaminophen antidotes Lars E. Schmidt. Department of Hepatology Rigshospitalet, Copenhagen. DNK

SY21-3 How can drug regulation reduce the public health burden of acetaminophen poisoning Nicholas Bateman. Clinical toxicology, University of Edinburgh. GBR

BARCELONAIUTOX 2010


29

16:30 SY22 MicroRNA Malefactors: role in chemically-induced toxicity / ROOM 5 Chairs: David Bell. European Chemicals Agency (ECHA) Víctor Sorribas. University of Zaragoza. ESP Sponsored by LRI - CEFIC (Long Ronge Research Initiative - The European Chemical Industry Council)

SY22-1 Roles for miRNAs in drug and chemical toxicity Emma Marczylo. MRC Toxicology Unit. GBR

SY22-2 The Role of miRNAs in PPARalpha Induced Hepatocellular Carcinomas Yatrik M Shah. University of Michigan. USA

SY22-3 microRNAs in cancer Anders Lund. BRIC, University of Copenhagen. DNK

SY22-4 Critical Roles of MicroRNAs in the Early Stages of Colon Carcinogenesis Masako Ochiai. National Cancer Center Research Institute, Tokyo. JPN SY22-5 Micrornas following DNA damage MAPK-mediated induction of miR-34c controls cell cycle arrest Martin Bushell. MRC Toxicology Unit. University of Leicester. GBR

16:30 SY23 Education and chemical safety in developing countries / ROOM 6 Chairs: Eduardo de la Peña de Torres. CSIC. Centro de Ciencias Medioambientales, Iberoamerican Net work Toxicology and Chemical Safety. ESP Silvia Barros. University of São Paulo. BRA

SY23-1 Education in Toxicology and Chemical Safety in Developing Countries Silvia Barros. University of Sau Paulo. BRA

SY23-5 Present and Future Challenges in Safety Assessment for Pharmaceuticals in Iberoamerica José Manautou. University of Connecticut. USA

SY23-2 Reality and Needs of Toxicology Research and Education in Developing Countries Fernanda Cavieres. Universidad of Valparaiso. CHL

SY23-3 Issues pertaining to toxicology and chemical safety in Africa Mary Gulumian. Toxicology and Biochemistry Section NIOH, Johannesburg. ZAF

SY23-4 The needs of Toxicological Research and Education in Continental Asia Junshi Chen. Institute of Nutrition and Food Hygiene. Chinese Acad. of Preventive Med. CHN


30

16:30 SY24 Immunotoxicology: From models to humans / ROOM 13 Chairs: Dori Germolec. Toxicology Branch. NTP/NIEHS. USA Miguel Borrás. Parc Cientific de Barcelona. ESP SY24-1 Overview of alternative methods in immunotoxicology E. Corsini. University of Milan. ITA

SY24-2 Chemical allergy: the relationships between in vitro tests, animal tests and clinical experience Ian Kimber. Faculty of Life Sciences, University of Manchester. GBR

SY24-3 Evidence for the immunotoxicity of perfluorinated compounds Dori Germolec. Toxicology Branch. NTP/NIEHS. USA

SY24-4 Developmental immunotoxicity of metals RR. Dietert. College of Veterinary Medicine, Cornell University, Ithaca. USA

BARCELONAIUTOX 2010


31

23 July, Friday9:00-10:00 KL04 Key Lecture / ROOM 7 Chairs: Alan Boobis. Imperial College London, UK. GBR María Prado Míguez. University of Extremadura. Veterinary Faculty. Cáceres. ESP

KL04 What makes a drug to be hepatotoxic?: how new technologies can help to better understand the phenomena José V. Castell. Unit for Experimental Hepatology. Research Institute of the University Hospital La Fe. Valencia. ESP


10:30 SY25 The changing face of clinical toxicology / ROOM 7 Chairs: Martin Wilks. Swiss Centre for Applied Human Toxicology. University of Basel. Switzerland Nancy Claude. Institut de Recherches Internationales Servier. Courbevoie. FRA Sponsored by Bo Holmstedt Memorial Fund (BMHF)

SY25-4 Is fundamental research in toxicology being translated into clinical practice? Peter Meier-Abt. University of Basel, Basel. CHE

SY25-1 Evidence base for the treatment of poisonings Nick Buckley. POW Hospital, Clinical School, University of NSW, Randwick. AUS

SY25-2 Can we define severity criteria for the common cardiotropic drugs taken in overdose? Bruno Megarbane. Hopital Lariboisière, Paris. FRA

SY25-3 New approaches of treatment in Paraquat poisoning Sae-Yong Hong. Department of Internal Medicine, Soonchunhyang University, Cheonan Hospital. Cheonan. KOR

10:30 SY26 Detoxication and susceptibility to anticholinesterase pesticides / ROOM 6 Chairs: Ramesh C. Gupta. Murray State University. USA Antonio Hernández. Universidad de Granada. ESP

SY26-1 Role of Albumin in the detoxification of organophosphorus and Carbamate Pesticides Miguel Angel Sogorb. Universidad Miguel Hernández de Elche. ESP

SY26-2 Variation in human liver enzymes involved in pesticide metabolism Elaine Mutch. Toxicology Unit, Clinical and Laboratory Sciences, The University of Newcastle, Newcastle upon Tyne. GBR

SY26-3 Genetic variability factors in human susceptibility to organophosphorus compounds Clement E. Furlong. University of Washington, Seattle. USA

SY26-4 Toxicity of Mixtures Containing Similarly and Dissimilarly Acting Compounds: New Concepts Sameeh. A. Mansour. National Research Centre, Dokki, Cairo. EGY


32

10:30 SY27 HBCD as a replacement flame retardant; another POP? / ROOM 5 Chairs: Linda Birnbaum. NIEHS. USA Joaquín Lapuente. Parc Cientific de Barcelona. ESP

SY27-5 Brominated Flame Retardants: Past, Future, and Regulations Linda Birnbaum. NIEHS. USA

SY27-1 Hexabromocyclododecane (HBCD) Complex Chemistry: Detection and Analytical Methods Adrian Covaci. University of Antwerp. BEL

SY27-2 HBCD levels in the Environment, Biota and Humans: Sterioisomeric paradox Rob J. Letcher. Environment Canada, Ottawa. CAN

SY27-3 Different HBCD Stereoisomers are Metabolized Differently! Heldur Hakk. USDA ARS Biosciences Research Lab. Fargo. ND SY27-4 Toxicity and Toxicokinetics of HBCD David Szabo. University of North Carolina Chapel Hill, NC. USA

10:30 SY28 Combined Exposures to Multiple Chemicals in Risk Assessment: A Pragmatic Approach / ROOM 13 Chairs: Carolyn Vickers. World Health Organization. Chemical Safety. Geneva, CHE Bette Meek. McLaughlin Centre for Population Health Risk Assessment University of Ottawa. CAN Partly sponsored by WHO (World Health Organization) and EFSA (European Food Safety Authority)

SY28-1 Considering Combined Exposures in Risk Assessment: Recent Developments, Opportunities and Challenges Bette Meek. McLaughlin Centre for Population Health Risk Assessment. University of Ottawa. CAN

SY28-2 Illustration of the WHO Combined Exposures Framework: A tiered and integrative approach to exposure and hazard Marcel T.M. van Raaij. Centre for Substances and Integrated Risk Assessment (SIR). National Institute for Public Health and the Environment (RIVM), Bilthoven. NLD

SY28-3 WHO Framework Case Study: Carbamates Elizabeth Shipp. BayerCropScience on behalf of ECETOC. FRA

SY28-4 Exploration of the Use of the Threshold of Toxicological Concern (TTC) and consideration of synergy for combined exposures Alan R. Boobis. Imperial College London, United Kingdom. GBR

SY28-5 Trends and developments in the risk assessment of chemical mixtures in food Djien Liem. European Food Safety Authority. ITA

BARCELONAIUTOX 2010


33

13:00-13:30 KL05 Final Conference (ECHA Lecture) ROOM 7 Chairs: Daniel Acosta (IUTOX) Nancy Claude (EUROTOX)

KL05 What has been REACHed? David Bell. Europen Chemical Agency (ECHA)

13:30 KL05 Closing Ceremony / ROOM 7

Results of ICT XII 2010, Barcelona, Congress President Remarks from President Spanish Association of Toxicology Invitation to EUROTOX 2011 Congress: Paris, France Invitation to ICT XIII, Seoul, Korea Remarks from President EUROTOX Remarks and Closing by IUTOX President

14:15 End of Congress


34

BUSSINES MEETINGS

20 July, Tuesday15:00-16:00 II REUNIÓN DE LA RED IBEROAMERICANA DE TOXICOLOGÍA Y SEGURIDAD QUÍMICA (RITSQ) / ROOM 8

18:30 Asamblea AETOX / ROOM 8

21 July, Wednesday8:05 EUROTOX Individual Member Meeting / ROOM 1

13:00 EUROTOX Business Council Meeting / ROOM 3

22 July, Thursday13:00 IUTOX General Assembly / ROOM 3

Information of place and time of meetings of executive committees, subcommittees, specialized sections, and other business meetings will be announced in a poster close to the Congress Secretariat.

TOXICOLOGY HISTORY ROOMTo appreciate the context of toxicology in the present, and plan for its future, it is critical that we understand its history. The International Congress of Toxicology -XII is pleased to present the Toxicology History Room (THR), an exhibit of posters providing a perspective on the history of the science of toxicology and its relation to society. Subjects will include noteworthy toxicologists and their contributions through the ages, organizations that have played a key role in scientific and regulatory affairs, chemicals which have been controversial, major toxic accidents, and more. We invite you to browse this selection of displays and suggest more for the expansion of the THR at future meetings. Though Isaac Newton did not invent the following phrase, it gained in popularity after he used it in a letter in the 17th century, in reference to some of his own accomplishments: “If I have seen a little further it is by standing on the shoulders of Giants.”

(Note: the contents of the posters are responsibility of their authors)

BARCELONAIUTOX 2010


35

��

��

�� !�"��#��$�� !�%�� &��'��(��!�%��!�%�� !��(�� (��(��)*�� +',�� !��

��

�� -��" �./��0 �./1��-��1��2�� !��&��-��&��1�� '��!�3��(�� !��(��4�5�6��5�6��(��7��.�� '��5�#��&��#��-&��1�5�'��(��$��5�6��(��#��5�#��8��/��-��!��1�5�$�� #��5�#��/��$�� 5�0.��#��

��%��(��(��!��%+9��:�5�*�� (��5�"��5�+��5��;��5� ��5�+�� 5� ��5� �� -�)��)��8/�<==>4�?===��0"'��0 '��8/��>@=?A1�5�6��(��

�� !�� B�� "�� *��CD� � '!�!�6��EF=� � � '�GD>�EF@�>D�CA�?@� � '�GC<�D<�@=<�?<>�C@�E@=C�+)�H�� E@==�##�H�� &�GD>�D=C�=F�<D�@D@� � &�GC<�D<�@=<�?<?�F@�� I��!��!;�� ! ��I��!��'�GE>�E=�F<C�C?�@E��&�GE>�E=�F<C�C=�<<��I��!��


36

P101: HUMAN BIOMONITORING

P101-002HAIR TOXIC MINERAL LEVELS AND BLOOD PRESSURE IN OMNIVORE AND SEMIVEGETARIAN POSTMENOPAUSALS. M. J. González Muñoz (1), S. Bastida (2), S. Rodenas

(3), M. T. Larrea (4), I. Sevillano (5), F. J. Sánchez Muniz (2). (1) Dpto. Nutrición, Bromatología y Toxicología. Facultad de Farmacia. Universidad de Alcalá, Alcalá de Henares, Spain; (2)

Departamento de Nutrición y Bromatología I (Nutrición). Facultad de Farmacia. Universidad Complutense, Madrid, Spain; (3) Sección Departamental de Química Analítica. Facultad de Farmacia. Universidad Complutense, Madrid, Spain; (4) Centro Nacional de Investigaciones Metalúrgicas. CSIC., Madrid, Spain; (5) Centro de Espectrometría Atómica. Universidad Complutense, Mdrid, Spain

P101-003ORGANOHALOGEN COMPOUNDS IN HUMAN CORD BLOOD FROM POLAND - PILOT STUDY. A. Hernik, K. Goralczyk, K. Czaja, P. Struciński, A. Kucharska, W. Korcz, T. Snopczyński, J. K. Ludwicki. National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland

P101-004RETROSPECTIVE ANALYSIS OF CORRELATION BETWEEN BLOOD ANTIEPILEPTIC DRUG LEVELS AND GENDER. Ö. Atlı (1), B. Sırmagül (2), S. Ilgın (1), Ö. Bolluk (2). (1)

Anadolu University, ESKISEHIR, Turkey; (2) Eskisehir Osmangazi University Medical Faculty,

P101-005ANIMALS AS SENTINELS OF HUMAN ENVIRONMENTAL RISKS: LEAD EXPOSURE BIOMONITORING ON PETS & CHILDREN. N. Mañay. Faculty of Chemistry, UDELAR, Montevideo, Uruguay

P101-006RELATIONSHIP BETWEEN METHYLMERCURY AND DHA IN PREGNANT WOMEN AND FETUSES: THE RISKS AND BENEFITS OF FISH CONSUMPTION. M. Sakamoto

(1), K. Murata (2), S. Kawakami (2), J. Domingo (1), K. Nakai (2), H. Satoh (2). (1) National Institute for Minamata Disease, Minamata, Japan; (2) ,

P101-007CONTROLLED HUMAN EXPOSURES TO ORGANIC SOLVENTS: INFLUENCE OF SEX ON URINARY LEVELS OF BIOLOGICAL INDICATORS. C. Tomicic (1), P. O. Droz (2), M. Berode (2), S. M. Praz Christinaz (2), V. Castella (3), B. Danuser (2). (1) Federal Office of Public Health (FOPH), Bern, Switzerland; (2) Institute for Work and Health (IST); (3) Unité de Génétique Forensique, Centre Universitaire Romand de Médecine Légale,

P101-008DETERMINATION OF ISOTRETINOIN IN HUMAN SERUM BY LC-MS/MS. H. S. Nam, H. J. Yoon, K. K. Jung, I. H. Kang, T. S. Kim, S. K. Hong, T. S. Kang. Korea Food and Drug Administration, SEOUL, Korea, Republic of

P101-009HUMAN BIOMONITORING OF PHTHALATES USING LC/MS/MS IN SOUTH KOREA. H. S. Nam, S. K. Hong, I. H. Kang, T. S. Kim, K. K. Jung, H. J. Yoon, T. S. Kang. Korea Food and Drug Administration, SEOUL, Korea, Republic of

P101-010TWO YEARS OF A BIOMONITORING STUDY OF MERCURY IN HUMAN HAIR AND URINE, MADRID (SPAIN). M. Esteban, A. Cañas, C. Navarro, J. E. Sánchez, J. A. Jiménez, M. Arribas, J. P. García, A. Castaño. Instituto de Salud Carlos III, Majadahonda, Spain

P101-011MARKERS OF OXIDATIVE STRESS AND GENOTOXICITY APPLIED IN RURAL WORKERS EXPOSED TO PESTICIDES. M. F. Simoniello (1), E. C. Kleinsorge (1), M. A. Carballo

(2). (1) Universidad Nacional del Litoral, Santa Fe, Argentina; (2) CIGETOX-Citogenética Humana y Genética Toxicológica. INFIBIOC. UBA,

P101-012REFERENCE VALUES FOR LEAD, CADMIUM AND MERCURY IN BLOOD OF ADULTS FROM THE METROPOLITAN AREA OF SÃO PAULO (BRAZIL). R. Kuno (1), M. H. Roquetti (1), K. Becker (2), M. Seiwert (2), N. Gouveia (3). (1) CETESB - Companhia Ambiental do Estado de São Paulo, São Paulo, Brazil; (2) German Federal Environmental Agency, Berlin, Germany; (3) Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

P101-013IMPROVED PROCEDURE FOR BIOMONITORING 28 ELEMENTS IN HUMAN HAIR: SAMPLE COLLECTION, TREATMENT AND ANALYTICAL METHOD BY ICP-MS. E. Vilanova, R. Ruiz, C. Estevan, M. A. Sogorb. Universidad Miguel Hernández, Elche, Spain

P101-014SECOND ORDER RATE CONSTANTS FOR THE IN VITRO REACTION OF THE TOXIC INDUSTRIAL CHEMICAL ACRYLONITRILE WITH THE MOST REACTIVE SITES IN HUMAN BLOOD. F. Benz, J. Cai, D. Nerland, H. Hurst, W. Pierce. Univ of Louisville Medical School, Louisville, United States

P101-015LIPID PROFILE AND PARAOXONASE 1 ACTIVITY IN TUNISIAN BIPOLAR I PATIENTS. A. Ezzaher (1), D. Haj Mouhamed (1), A. Mechri (2), F. Neffati (2), W. Douki (2), L. Gaha (2), M. F. Najjar (2). (1) Student, Monastir, Tunisia; (2) ,

P101-016USING HUMAN SERUM ALBUMIN TO PERFORM ADDUCTOMICS IN POPULATIONS OF INTEREST. S. Rappaport (1), H. Li (1), W. Funk (2), H. Gregoryan (1), M. Demireva (1), E. Williams (1), A. Iavarone (1), S. Lu (1), S. Rose (1), M. Van Der Laan (1). (1) University of California, Berkeley, Berkeley, United States; (2) University of North Carolina, Chapel Hill

P101-017DERIVATION OF MARGINS OF EXPOSURE FROM HUMAN BIOMONITORING DATA: A CHEMICAL INDUSTRY PERSPECTIVE. M. Bartels, S. Arnold, C. Burns, L. Pottenger, J. Pitt, M. S. Marty, S. Saghir, H. Hollnagel, N. Ball. The Dow Chemical Company, Midland, United States

P101-018DEVELOPMENT OF PK- AND PBPK-BASED MODELING TOOLS FOR DERIVATION OF BIOMONITORING GUIDANCE VALUES. M. Bartels (1), G. Loizou (2), P. Price (1), D. Rick (1), M. Spendiff (2), S. Arnold (1), J. Cocker (2), N. Ball (1). (1) The Dow Chemical Company, Midland, United States; (2) Health and Safety Laboratory, UK

POSTERS

BARCELONAIUTOX 2010


37

P101-019HUMAN EXPOSURE TO DDT/DDE IN SANTA CRUZ DE LA SIERRA (BOLIVIA). A GENDER PERSPECTIVE. J. P. Arrebola (1), M. Cuellar (2), E. Claure (2), M. Quevedo (2), R. Antelo (2), N. Olea (3), L. A. Mercado (2). (1) Spanish Agency for International Co-operation. San Cecilio University Hospital. Spain, Granada, Spain; (2) Gabriel Rene Moreno University. Bolivia; (3) University of Granada. CIBER en Epidemiología y Salud Pública (CIBERESP). Spain

P101-020ACCUMULATION OF ORGANOCHLORINE PESTICIDES IN HUMAN VISCERAL AND SUBCUTANEOUS ADIPOSE TISSUE - THE PORTUGUESE SCENARIO. D. Pestana

(1), V. Fernandes (2), D. Teixeira (1), A. Faria (3), R. Monteiro (1), V. Domingues (4), C. Delerue-Matos (4), C. Calhau (1). (1) Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, Porto, Portugal; (2) Requimte - Instituto Superior de Engenharia, Instituto Politécnico do Porto and Chemistry Investigation Centre (CIQ), Faculty of Sciences, University of Porto, Porto, Portugal; (3) Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto and Chemistry Investigation Centre (CIQ), Faculty of Sciences, University of Porto, Portugal; (4) Requimte - Instituto Superior de Engenharia, Instituto Politécnico do Porto, Portugal

P101-021EFFECTS OF THE INTERACTION OF TOBACCO SMOKE AND ALCOHOL CONSUMPTION ON BUCCAL MICRONUCLEUS IN WORKERS OCCUPATIONALY EXPOSED TO FORMALDEHYDE. C. Ladeira (1), S. Viegas (1), E. Carolino (1), J. Prista (2), M. C. Gomes (3), M. Brito (1). (1) Escola Superior de Tecnologia da Saúde de Lisboa, Lisboa, Portugal; (2)

Escola Nacional de Saúde Pública - Universidade Nova de Lisboa; (3) Faculdade de Ciências - Universidade de Lisboa,

P101-022TOXICOKINETIC MODELING OF CYPERMETHRIN AND PERMETHRIN FOR DOSE RECONSTRUCTION IN THE POPULATION. J. Côté (1), M. Bouchard (1), G. Carrier (1), R. Heredia Ortiz (1), U. Fuhr (2), B. Woollen (3), C. Lapointe (4), Y. Bonvalot (4). (1) University of Montreal, Montreal, Canada; (2) University of Cologne; (3) Syngenta; (4) Health Canada,

P101-023ACROLEIN AND ACRYLAMIDE: EXPOSURE ESTIMATION OF FOOD BORNE TOXICANTS BY MONITORING MERCAPTURIC ACIDS IN HUMAN URINE AFTER CONSUMPTION OF POTATO CRISPS. M. Baum (1), N. Watzek (1), F. Berger (1), J. Feld (1), O. Doroshyenko (2), D. Tomalik-Scharte (2), U. Fuhr (2), G. Eisenbrand (1), E. Richling (1). (1)

Department of Food Chemistry and Toxicology, University of Kaiserslautern, Germany, Kaiserslautern, Germany; (2) Department of Pharmacology, University of Cologne, Germany,

P101-024SELECTION OF SAMPLING MATERIAL FOR THE ANALYSIS OF HEAVY METALS IN BLOOD FOR HUMAN BIOMONITORING STUDIES. A. Cañas Portilla, A. Castaño Calvo, M. Esteban López, C. Navarro Rivas, J. A. Jimenez Guerrero. Instituto de Salud Carlos III, Majadahonda, Spain

P101-025CHARACTERIZATION OF BIOSORPTION PROCESS OF AMITRIPTYLINE ON ACTIVATED CHARCOAL AND RICE BRAN. A. Jamshidzadeh, F. Vahedi. Faculty of Pharmacy, Shiraz, Iran (Islamic Republic of)

P101-026RISK FACTORS FOR MUTAGENICITY AND CYTOTOXICITY OF ORAL EPITHELIAL CELLS IN THE BRAZILIAN HAIRDRESSERS AS ASSESSED BY THE MICRONUCLEUS TEST. D. Ribeiro, V. Carlin, A. C. Fracalossi, R. Pozzi, S. Miranda, J. F. Rodrigues, T. Gomes, O. Aguiar, L. Oyama, C. Oshima. Federal University of Sao Paulo, Santos, Brazil

P101-027THE APPLICABILITY OF BIOLOGICAL MONITORING OF STYRENE TO SALIVA MATRIX: A PRELIMINARY ASSESSMENT. M. Gherardi (1), L. Caporossi (1), A. Santoro (2), A. Gordiani (1), M. P. Gatto (1). (1) National Institute for Occupational Safety and Prevention, Rome, Italy; (2) University of Rome “La Sapienza”, Italy

P101-028MARKERS OF THE ADIPOSE TISSUE FOR THE ASSESSMENT OF CARDIO-VASCULAR RISK IN METABOLIC SYNDROME PATIENTS. D. Margina (1), D. Gradinaru (1), C. Panaite (2), M. Vladica (2), N. Mitrea (1). (1) Faculty of Pharmacy, Bucharest, Bucharest, Romania; (2) ,

P101-029RESPONSE OF NEWZEALAND RABBITS TO DRINKING WATER TREATMENT WITH ALUM AND POLYDADMAC IN TERMS OF CHANGE IN ELECTROYTES. A. Medani, S. Elbadwi, A. Amin. Khartoum College of Medical Sciences, Khartoum, Sudan

P101-030EVALUATION OF P16 EXPRESSION IN ORAL MUCOSA CELLS OF PEOPLE WITH CYTOGENETIC DAMAGE. A. L. González-Yebra, B. González, G. Barbosa, C. Mendiola, R. Huerta, K. Wrobel, K. Wrobel. Universidad de Guanajuato, León, Mexico

P102: EPIDEMIOLOGICAL TOXICOLOGY

P102-001EPIDEMIOLOGICAL CHARACTERISTICS OF SCORPIONISM IN BENI MELLAL PROVINCE. N. Charrab (1), H. Hami (1), A. Soulaymani (1), I. Semlali (2), A. Mokhtari (1), R. Soulaymani (2). (1) faculty of sciences kenitra, kenitra, Morocco; (2) Poison Control and Pharmacovigilance Center of Morocco, Rabat,

P102-002INFECTIOUS DISEASES IN INTRA VENOUS SUBSTANCE USERS IN TEHRAN. B. Mostafazadeh (1), T. Afsharian (2). (1) Shaheed Beheshty University of Medical Sciences, Tehran, Iran (Islamic Republic of); (2) Private Physician, Tehran, Iran (Islamic Republic of)

P102-003RETROSPECTIVE EVALUATION OF DRUG-RELATED CASES ADMITTED TO EMERGENCY DEPARTMENT OF OSMANGAZÝ UNIVERSITY HOSPITAL BETWEEN 2005-2008. A. Saraçoğlu (1), D. Uzuncakara (1), S. Ilgin (1), A. Çevik (2), B. Ergun (1). (1) Anadolu University, Faculty of Pharmacy, Eskişehir, Turkey; (2) Osmangazi University, Faculty of Medicine, Eskişehir, Turkey

P102-004PARAOXANASE 1 (PON1) POLYMORPHISMS AND HAPLOTYPES AS RISK FACTORS FOR HAVING SPINA BIFIDA-AFFECTED OFFSPRING IN SOUTHEAST MEXICO. B. Quintanilla-Vega (1), L. González-Herrera (2), J. Canto-Herrera (2), D. Pinto-Escalante (2), R. Cerda-Flores (3). (1) Centro de Investigación y Estudios Avanzados del IPN, México, Mexico; (2) Universidad Autónoma de Yucatán, Mérida, Mexico; (3) Universidad Autónoma de Nuevo León, Monterrey, Mexico

P102-005ANALYSIS OF GENDER-RELATED DIFFERENCES AMONG THE PATIENTS WITH SUICIDAL DRUG INTOXICATION. S. Ilgın (1), A. Saraçoğlu (1), Ö. Atlı (1), N. Acar (2). (1) Anadolu University, Faculty of Pharmacy, Eskişehir, Turkey; (2) Osmangazi University, Faculty of Medicine,

P102-006ASSOCIATION OF BLOOD LEAD AND BLOOD PRESSURE IN THE NHANES 1999-2006. F. Scinicariello, H. Abadin, H. E. Murray. CDC/ATSDR, Atlanta, United States


38

P102-007CLINICAL PRESENTATIONS SKIN BY BITING SPIDERS GENUS LOXOSCELES. TOXICOLOGY SERVICE EXPERIENCE FROM CHILDREN’S HOSPITAL OF THE BLESSED TRINITY, PROVINCE OF CORDOBA, ARGENTINA, DURING 2006-2009. M. Aliaga, N. Gait, R. Llebeili, M. Pierotto, A. Suarez, A. Gait. Hospital de niños de la santisima trinidad, cordoba, Argentina

P102-008CHILEAN CHILDHOOD POISONING 2006-2009: CHARACTERIZATION USING INTOX DMS. M. Bettini Silva (1), J. J. Mieres Araya (1), J. C. Rios Bustamante (2), S. Solari Gajardo

(2), M. Perez Cabrera (1), V. Bravo Gonzalez (1), P. Cerda Jimenez (1), E. Paris Mancilla (1) (1) Centro de Información Toxicológica de la Pontificia Universidad Católica de Chile (CITUC), Santiago, Chile; (2) Departamento de Laboratorios Clínicos, Facultad de Medicina, Pontificia Universidad Católica de Chile,

P102-009GLOBAL DNA METHYLATION AND RISK OF BREAST CANCER IN MEXICAN WOMEN. R. U. Hernández-Ramírez (1), J. Chen (2), X. Xu (2), M. E. Cebrian (3), M. Galván-Portillo

(1), L. Torres-Sánchez (1), I. Silva-Zolezzi (4), L. López-Carrillo (1). (1) National Institute of Public Health, Cuernavaca, Mexico; (2) Mount Sinai School of Medicine; (3) Research and Advanced Studies Center of the National Polytechnic Institute of Mexico (Cinvestav - IPN); (4) National Institute of Genomic Medicine, Mexico

P102-010ESTIMATION OF POSTNATAL INTERNAL EXPOSURE TO ORGANOCHLORINE COMPOUNDS IN THE INMA-SABADELL BIRTH COHORT (SPAIN). M. A. Verner (1), M. Guxens (2), J. Sunyer (2), J. O. Grimalt (3), R. Mcdougall (4), M. Charbonneau (5), S. Haddad (1). (1) Université du Québec à Montréal, Montreal, Canada; (2) Centre de Recerca en Epidemiologia Ambiental (CREAL); (3) Department of Environmental Chemistry, IDÆA-CSIC; (4) University of Ontario Institute of Technology; (5) INRS-Institut Armand-Frappier,

P102-011MODELING THE IMPACT OF SHORT-TERM VARIATIONS IN TRIHALOMETHANE DRINKING WATER LEVELS ON INTERNAL EXPOSURE. C. Catto (1), M. Rodriguez (2), J. Lavoué (1), G. Charest-Tardif (1), R. Tardif (1). (1) Université de Montréal, Montréal, Canada; (2) Université Laval à Québec,

P102-012DATA HARMONIZATION: COMPARATIVE STUDY OF FOUR POISON CENTRES USING INTOX DATA MANAGEMENT SYSTEM SOFTWARE. J. C. Rios Bustamante (1), L. Fruchtengarten (2), C. Meneses (3), A. M. Lynch (4), J. Tempowski (5), M. Bettini (1), J. J. Mieres (1), A. Zucollo (2), E. Paris (1). (1) Centro de Información Toxicológica de la Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; (2) Poison Control Centre of Sao Paulo, Brazil; (3) Centro de Informacion y Asesoramiento Toxicológico, Ecuador; (4) Western Australian Poisons Information Centre, Australia; (5) WHO IPCS International Programme on Safety, Geneva, Switzerland,

P102-013GLOBAL DNA METHYLATION IN RELATION TO DDT EXPOSURE AND GENETICAL SUSCEPTIBILITY AMONG PREGNANT WOMEN IN MORELOS, MEXICO. R. Ruiz-Ramos (1), L. Torres-Sanchez (2), M. La Merrill (3), L. López-Carrillo (2), J. Chen (3), M. E. Cebrián (1). (1) CINVESTAV-IPN, Mexico City, Mexico; (2) INSP, Cuernavaca, Mexico; (3) Mount Sinai School of Medicine, New York, United States

P102-014PON1 STATUS AND BLOOD CHOLINESTERASES IN A FARMWORKER POPULATION EXPOSED TO ORGANOPHOSPHATE PESTICIDES. E. Moreira (1), W. Griffith (2), G. Coronado (3), B. Thompson (3), E. Vigoren (2), R. Richter (4), C. Furlong (4), E. Faustman (2). (1) Dept of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil, Londrina, Brazil; (2) Institute for Risk Analysis and Risk Communication, DEOHS, University of Washington, Seattle, WA, USA, Seattle, United States; (3) Fred Hutchinson Cancer Research Center, Seattle, WA, USA; (4) Dept of Medicine, University of Washington, Seattle, WA, USA,

P102-015DECREASED SEMEN QUALITY IN AGRICULTURAL WORKERS FROM SOUTHERN MEXICO: A LONGITUDINAL STUDY. N. Pérez-Herrera (1), H. Polanco-Minaya (2), E. Salazar-Arredondo (2), M. J. Solís-Heredia (2), J. Alvarado-Mejía (1), T. Castillo-Burguete (2), V. Borja-Aburto (3), L. González-Navarrete (1), B. Quintanilla-Vega (2). (1) University of Yucatán, Mérida, Mexico; (2) CINVESTAV, D.F., Mexico; (3) IMSS, D.F., Mexico

P102-016ACCIDENTAL POISONING BY PLANTS, 2000-2007. H. Hami (1), N. Charrab (1), A. Soulaymani (1), L. Ouammi (2), A. Mokhtari (1), R. Soulaymani (2). (1) Laboratory of Genetic and Biometry, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco, Kenitra, Morocco; (2) Morocco Poison Control Center, Rabat, Morocco,

P102-017FLUORIDE IN ENAMEL SAMPLES OF 12-YEARS OLD SCHOOLCHILDREN DEPENDING ON FLUORIDE CONTENT IN DRINKING WATER. M. Curcic, Z. Mandinic, M. Carevic, B. Antonijevic. University of Belgrade, Belgrade, Serbia

P102-018ACTIVITY OF THE VETERINARY TOXICOLOGY ATTENTION SERVICE OF LUGO, NW SPAIN. M. Pérez López (1), M. C. Nóvoa Valiñas (2), M. A. García Fernández (2), M. J. Melgar Riol (2). (1) Faculty of Veterinary Medicine UEx, Caceres, Spain; (2) Faculty of Veterinary Medicine USC, Lugo, Spain

P102-019POISONINGS IN DOMESTIC ANIMALS: 2009 REPORT OF THE POISON CONTROL CENTRE OF MILAN. C. Cortinovis (1), M. Rivolta (1), F. Davanzo (2), F. Caloni (1). (1) Università degli Studi di Milano, Department of Veterinary Sciences and Technologies for Food Safety Via Celoria 10, 20133 Milan, Italy, Milan, Italy; (2) Poison Control Centre of Milan, Niguarda Hospital, Milan, Italy, Milan, Italy

P102-020EPYDEMIOLOGY OF POISONING ON A PEDIATRIC THIRD LEVEL HOSPITAL DURING LAST SEVENTEEN YEARS IN A DEVELOPING COUNTRY. O. Martinez, E. Bustos, M. Ceron, V. Olivar, C. Bañuelos. Hospital Infantil de México Federico Gómez, México, Mexico

P102-021SURVEY OF PERSISTENT ORGANIC POLLUTANTS IN HUMAN MILK FROM COMMUNITIES URBAN AND COAST FROM YUCATAN PENNINSULA, MEXICO. R. L. González-Navarrete (1), J. A. Alvarado-Mejía (1), N. . E. Pérez-Herrera (1), G. Gold-Bouchot (2), J. P. Rodas-Ortiz (2), V. Ceja-Moreno (2). (1) la Facultad de Medicina, Universidad Autónoma de Yucatán, Merida,, Mexico; (2) CINVESTAV Unidad Mérida, Merida,, Mexico

P102-022BIRTH COHORT STUDY GESTE: COULD CORD BLOOD BIOMARKERS SAY US HOW NEUROTOXIC METALS AFFECT THE FOETAL BRAIN AT LOW DOSE? FIRST DATA ON PROLACTIN AND MONOAMINE OXIDASE. N. Abdelouahab, L. Takser. University of Sherbrooke, SHERBROOKE, Canada

P102-023SELENOPROTEINS AND BLADDER CANCER RISK: A CASE-CONTROL STUDY. A. F. S. Amaral (1), N. Rothman (2), M. Kogevinas (3), M. Calle (4), L. T. Guey (1), M. García-Closas

(2), D. T. Silverman (2), S. Chanock (2), F. X. Real (1), N. Malats (1). (1) Spanish National Cancer Research Centre (CNIO), Madrid, Spain; (2) National Cancer Institute (NCI), United States; (3)

Municipal Institute of Medical Research (IMIM), Spain; (4) University of Vic, Spain

BARCELONAIUTOX 2010


39

P102-024EXPOSURE TO PERFLUORINATED COMPOUNDS AND THE RISK OF BREAST CANCER IN GREENLANDIC INUIT. M. Long, E. C. Bonefeld-Jorgensen. Centre of Arctic Environmental Medicine, Unit of Cellular and Molecular Toxicology, Aarhus, Denmark

P102-025DOES EXPOSURE TO PERSISTENT ORGANIC POLLUTANTS (POPS) INCREASE THE RISK OF BREAST CANCER? E. C. Bonefeld-Jorgensen, M. Long. Centre of Arctic Environmental Medicine, Unit of Cellular and Molecular Toxicology, Aarhus, Denmark

P102-031PERSONAL CARE PRODUCTS AND URINARY LEVELS OF PHTHALATES IN MEXICAN WOMEN. M. Romero Franco (1), R. U. Hernández-Ramírez (1), A. Calafat (2), M. E. Cebrián-García (3), L. Needham (2), S. Teitelbaum (4), M. Wolff (4), L. López-Carrillo (1). (1) Population Health Research Center. National Institute of Public Health, Mexico, Cuernavaca, Mexico; (2) Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, USA; (3) Toxicology Division. Center for Research and Advanced Studies, México; (4) Center for Children’s Environmental Health and Disease Prevention Research. Mount Sinai School of Medicine, USA

P102-038DESCRIPTION OF THE CLINICAL FEATURES SEEN IN PATIENTS WITH MEPHEDRONE TOXICITY. D. M. Wood, S. L. Green, P. I. Dargan. Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom

P103: ENVIRONMENTAL HEALTH

P103-001TOXIC EFFECTS OF LAMBDA-CYHALOTHRIN, A SYNTHETIC PYRETHROID PESTICIDE, ON THE RAT KIDNEY: INVOLVEMENT OF OXIDATIVE STRESS AND PROTECTIVE ROLE OF ASCORBIC ACID. H. Fetoui, N. Zeghal. Faculty of Sciences, Sfax, Tunisia

P103-002EFFECT OF FLURIDE, CADMIUM AND ARSENIC INTOXICATION ON BRAIN AND LEARNING-MEMORY ABILITY IN RATS. H. Kaoud, B. Kalifa. Fac.Vet.Med.,Cairo University, Giza, Egypt

P103-003DISTINGUISHING OF PERMANENT AND CASUAL RISKS OF WATER POLLUTION IN TRANSITING COUNTRY WITH USING INDIGENOUS MOLLUSKS. H. Falfushynska

(1), L. Gnatyshyna (1), O. Stoliar (1), J. Gyori (2), Á. Vehovszky (2), A. Farkas (2). (1) Ternopil National Pedagogical University, Ternopil, Ukraine; (2) Balaton Limnological Research Institute, Tihany, Hungary

P103-004METABOLOMICS, A NEW APPROACH TO IDENTIFY BIOMARKERS OF 137CS HEALTH EFFECTS. S. Grison (1), J. C. Martin (2), I. Dublineau (1), P. Gourmelon (1), M. Souidi (1).(1) IRSN, Fontenay-aux-Roses, France, Metropolitan; (2) INRA 1260, France

P103-005POTENTIAL HEALTH AND ENVIRONMENT THREATS CONNECTED WITH CHEMICAL ACCIDENTS IN POLAND IN 2005-2007. A. Pałaszewska-Tkacz, S. Czerczak. Nofer Institute of Occupational Medicine, Lodz, Poland

P103-006CADMIUM LEVELS IN BLOOD AND TISSUES AND THE CORRELATION BETWEEN BLOOD CADMIUM AND PLASMA TESTOSTERONE IN BEEF CATTLE. T. Trakranrungsie, P. Yatmark, C. Nakthong. Mahidol University, Nakhonpathom, Thailand

P103-007EFEECT OF CYP1A1 AND EPHX1 POLYMORPHISMS ON THE LEVEL OF BPDE-ALB ADDUCTS IN PAH-ENVIRONMENTAL EXPOSURE. J. Sirivarasai, S. Kaojarern, S. Thanyachai, K. Yoovathaworn, K. Petchpoung. Mahidol University, Bangkok, Thailand

P103-008ENVIRONMENTAL POLLUTION IN THE PETROCHEMICAL AREA OF TARRAGONA, SPAIN. HEALTH RISKS DERIVED FROM MULTICHEMICAL EXPOSURE. M. Nadal, J. L. Domingo, L. Vilavert, M. Mari, M. Schuhmacher. Universitat Rovira i Virgili, Reus, Spain

P103-009BISPHENOL A & THE NON-MONOTONIC DOSE RESPONSE: WHY ENVIRONMENTALLY RELEVANT DOSES POSE MORE DANGER THAN PHARMACOLOGICAL DOSES. S. Jenkins, C. Lamartiniere. University of Alabama at Birmingham, Birmingham, United States

P103-010POSSIBLE HYPOTHESES ON THE DISCREPANCY BETWEEN THE LITERATURE DATA ON THE EFFECTS OF AMBIENT AIR POLLUTION AND PREGNANT WOMEN AND BIRTH OUTCOMES. G. Polichetti (1), K. Grigoropoulos (2), R. Polichetti (1), D. Capone (1), I. Montoro (1), C. Attianese (1), M. Russo (3), I. Kadilli (1), A. Nunziata (4), A. Gentile (1). (1) Department of Neurosciences, Unit of Clinical Pharmacology, School of Medicine, Federico II, University of Naples, Naples, Italy; (2) University of Patras, Geology and Environment, 26500, Patras, Greece; (3) Department of Neurosciences, Unit of Physiology, School of Medicine, Federico II, University of Naples; (4) Consultant, Via Mar Nero 31, 00040 Pomezia, Italy.,

P103-011ESTROGNIC EFFECT OF SECOND-HAND CIGARETTE SMOKE IN LUNG CANCER CELL LINES EXPRESSING DIFFERENT RECEPTOR PHENOTYPES. L. C. Kuo, S. F. Lin, L. A. Li. National Health Research Institutes/Division of Environmental Health & Occupational Medicine, Miaoli, Taiwan

P103-012BISPHENOL A-INDUCED AROMATASE ACTIVATION IS MEDIATED BY CAMP RESPONSE ELEMENT ACTIVATION IN RAT TESTICULAR LEYDIG CELLS. E. H. Han (1), J. Y. Kim (2), K. Y. Lee (2), H. G. Jeong (1). (1) Chungnam National University, Daejeon, Korea, Republic of; (2) Chonnam National University,

P103-013BDE-99 EXPOSED RATS: AN ASSESSMENT OF THE HORMONAL STATUS AND BIOCHEMICAL PARAMETERS IN ADULT ANIMALS. V. Alonso, M. Bellés, M. L. Albina, V. Linares, A. Pujol, D. Sánchez, J. L. Domingo. School of Medicine, IISPV “Universitat Rovira i Virgili”, Reus, Spain

P103-014CONCENTRATIONS OF URINARY PHTHALATES METABOLITES IN MEXICAN WOMEN WITH AND WITHOUT DIABETES. K. Svensson (1), R. U. Hernández-Ramírez (2), A. Burguette (2), M. Cebrian (3), L. Claudio (4), L. López-Carrillo (2). (1) Graduate School of Public Health, University of Puerto Rico, San Juan, United States; (2) National Institute of Public Health. Cuernavaca, Morelos, México; (3) Sección Externa de Toxicología. Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional. Mexico City, México; (4) Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, USA,


40

P103-015NANOPARTICLE-RICH DIESEL EXHAUST-DISRUPTED TESTOSTERONE BIOSYNTHESIS AND METABOLISM MIGHT BE MEDIATED BY GROWTH HORMONE. D. H. Ramdhan (1), Y. Ito (2), Y. Yanagiba (1), N. Yamagishi (1), Y. Hayashi (1), A. K. Suzuki (3), T. Nakajima (1). (1) Nagoya University Graduate School of Medicine, Nagoya, Japan; (2) Nagoya City University Graduate School of Medicine; (3) Japan National Institute for Environmental Studies, Research Center for Environmental Risk,

P103-016FLAVONE REGULATION OF STEROIDOGENIC CYP11B1 AND CYP11B2 GENES. L. C. Cheng, J. R. Lin, L. A. Li. Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan

P103-017CHRONIC OVERESPOSURE TO URANIUM PREDISPOSES TO ACUTE RENAL FAILURE. L. Vicente Vicente (1), P. D. Sánchez González (1), M. Prieto (1), J. M. López Novoa (1), F. J. López Hernández (2), A. I. Morales (1). (1) Universidad de Salamanca, Salamanca, Spain; (2) Hospital Universitario de Salamanca, Spain

P103-018PRESENCE OF ANTIMICROBIAL RESISTANCES AND ANTIMICROBIAL RESIDUES IN ANIMAL MANURE. A. De La Torre, B. Vázquez, F. Esperon, M. Carballo. CISA-INIA, Valdeolmos, Spain

P103-019AGE-RELATED BRAIN SUSCEPTIBILITY TO PARAQUAT-INDUCED OXIDATIVE STRESS. EFFECTS OF EXOGENOUS MELATONIN. A. Ramos Chamizo, S. Regodón, M. D. P. Miguez. Universidad de Extremadura / Facultad de Veterinaria, Cáceres, Spain

P103-020EFFECT-RELATED CHARACTERIZATION OF PARTICULATE MATTER EXPOSURE FOR THE CITY OF AACHEN. S. Michael (1), G. Lehnert (1), H. Merbitz (2), C. Schneider (2), W. Dott (1). (1) Institute of Hygiene and Environmental Medicine, RWTH Aachen University, Aachen, Germany; (2) Department of Geography, RWTH Aachen University,

P103-021PROTEOME CHANGES IN RAT SERUM AFTER A CHRONIC INGESTION OF URANIUM. F. Petitot, S. Frelon, O. Delissen, F. Paquet, M. Benderitter, O. Guipaud. IRSN, Pierrelatte, France

P103-022EXPOSURE TO PERSISTENT ORGANIC POLLUTANTS (POPS) AND GENOTOXIC EFFECTS IN FISH AND GIANT TOADS OF COATZACOALCOS, VERACRUZ, MEXICO. J. Mejía-Saavedra (1), D. González-Mille (1), C. Ilizaliturri-Hernández (1), G. Espinosa-Reyes (1), M. Á. Martínez (2), R. Costilla-Salazar (3), F. Díaz-Barriga (1). (1) Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico; (2) Instituto Nacional de Ecología; (3) Unidad Profesional Interdisciplinaria de Ingenieria campus Guanajuato,

P103-023HEALTH IMPACTS OF POPULATION EXPOSED TO ATMOSPHERIC EMISSIONS IN AN INDUSTRIAL REGION OF MEXICO. E. M. Melgar-Paniagua (1), E. Vega (2), L. M. Del Razo (1), C. A. Lucho-Constantino (3), S. L. Rothenberg (4), A. De Vizcaya-Ruiz (1). (1) Cinvestav-Ipn, Mexico City, Mexico; (2) Instituto Mexicano Del Petroleo, Mexico; (3) Universidad Politecnica De Pachuca, Mexico; (4) Cinvestav-Ipn/Insp, Mexico

P103-024STUDY CONCERNING THE IMPACT OF GLYPHOSATE ON MICROBIAL ACTIVITY OF SOILS. E. Alexa (1), R. Sumalan (1), M. Negrea (1), A. Doncean (1), C. Dehelean (2), G. Pop (1). (1) Banat University of Agricultural Sciences and Veterinary Medicine Timisoara, Timisoara, Romania; (2) University of Medicine and Pharmacy Timişoara, Romania

P103-025ASSOCIATION BETWEEN CIGARETTE SMOKING AND URIC ACID CONCENTRATION. D. Haj Mouhamed (1), A. Ezzaher (1), F. Neffati (2), A. Mechri (2), W. Douki (2), L. Gaha (2), M. F. Najjar (2). (1) Student, Monastir, Tunisia; (2) ,

P103-026A NEW BATTERY FOR SCREENING LEAD POISONED NEONATES IN EGYPT. Y. Taalab. Faculty of Medicine-Mansoura University, mansoura, Egypt

P103-027THERMAL EFFECT OF CLINICAL BRAIN MRI PROTOCOL WITH HIGH MAGNETIC FIELDS(1.5 AND 3.0 TESLA MRI) IN A PHANTOM MODEL PORK SAMPLE. M. S. Kim (1), Y. J. Kim (2). (1) National Cancer Center, The Graduate school of Public Health Seoul National University, Goyang-si, Korea, Republic of; (2) The Graduate School of Public Health, Seoul National University, seoul, Korea, Republic of

P103-028OCCURRENCE OF PHARMACEUTICALS IN RIVER AND TAP WATERS OF TOLEDO (CASTILLA-LA MANCHA COMMUNITY, SPAIN). R. Feito (1), J. C. Montero Rubio (2), J. Fernández (3). (1) Rey Juan Carlos University, Alcorcon (Madrid), Spain; (2) Jefe de Sección de Microbiología Clínica y Ambiental Servicio de Laboratorio Instituto de Ciencias de la Saud de Castilla La Mancha Carretera de Extremadura Km 114, Talavera de la Reina; (3) Departamento Biología y Geología Universidad Rey Juan Carlos (ESCET), Móstoles

P103-029ARISTOLOCHIC ACID SUPPRESSES DNA REPAIR AND TRIGGERS OXIDATIVE DNA DAMAGE IN HUMAN KIDNEY PROXIMAL TUBULAR CELLS. S. Y. Chiang, Y. Y. Chen, J. G. Chung, P. Y. Lee, H. F. Huang, C. Y. Hsiang, T. Y. Ho. China Medical University, Taichung, Taiwan

P103-030SAFETY EVALUATION OF XIXIN, A MEDICINAL HERB FROM THE ARISTOLOCHIACEAE FAMILY, AND ITS FORMULA IN MICE. H. C. Wu, S. F. You, W. Y. Tien, P. C. Hsu, Y. Y. Chen, H. N. Cheng, M. Y. Lin, S. Y. Chiang. China Medical University, Taichung, Taiwan

P103-031HEAVY METALS AND ESSENTIAL ELEMENTS IN BONES OF THREE SPECIES OF PENGUINS FROM KING GEORGE ISLAND, ANTARCTICA. S. Jerez (1), M. Motas (1), J. Benzal (2), A. Martínez (2), F. Valera (2), A. Barbosa (3). (1) University of Murcia, Murcia, Spain; (2) Estación Experimental de Zonas Áridas, CSIC, Spain; (3) Museo Nacional de Ciencias Naturales, CSIC, Spain

P103-032DETERMINATION OF ESTROGENS (ESTRIOL, B – ESTRADIOL, ESTRONE AND 17 B – ETHYNYLESTRADIOL) IN RIVER WATER FROM A RURAL AREA IN MIDWEST BRAZIL. G. Julião Zocolo (1), A. Cicero De Sousa (2), M. N. Teodoro Lopes (3), M. R. Rodrigues De Marchi (1). (1) Instituto de Química, UNESP, Araraquara, Brazil; (2) Instituto Federal de Educação, Ciência e Tecnologia da Paraíba-IFPB, João Pessoa, Brazil; (3) Universidade Federal da Grande Dourados – UFGD,

P103-033DETERMINATION OF POSSIBLE GENOTOXIC RISKS RELATED TO TOXIC SUBSTANCES RESULTED FROM COAL PLANT IN INDIVIDUALS RESIDING AFSIN-ELBISTAN THERMAL POWER PLANT AREA VIA COMET ASSAY. E. Durmaz, O. K. Ulutas, İ. Çok. Gazi University Faculty of Pharmacy, Ankara, Turkey

BARCELONAIUTOX 2010


41

P103-034ACTIVATION OF BIOLOGICAL PATHWAYS IN THE LUNGS AND HEART BY PARTICULATE MATTER AND OZONE. E. Thomson, D. Vladisavljevic, R. Vincent, P. Kumarathasan. Health Canada, Ottawa, Canada

P103-035TOXICOLOGICAL AND PRO-INFLAMMATORY CHARACTERISTICS OF SAHARAN DUST CONSTITUENTS REACHING PUERTO RICO. B. Jimenez-Velez (1), M. Ortiz-Martínez (1), R. Rodríguez-Cotto (1), E. Rivera-Ramírez (2), L. Méndez-Torres (3). (1) University of Puerto Rico, MSC, San Juan, Puerto Rico; (2) University of Puerto Rico at Rio Piedras; (3)

University of California at Irvine,

P103-036NEUROBEHAVIORAL EFFECTS OF ORGANOTIN EXPOSURE: POSSIBLE RELEVANCE TO LONG-TERM MOOD DISORDERS. S. T. Szabo, J. G. Harry. Duke University/National Institutes of Environmental Health, Durham, United States

P103-037ENVIRONMENTAL HEALTH: CHALLENGES AND OPPORTUNITIES FOR HEALTH AND ENVIRONMENT INTEGRATED MANAGEMENT. E. Barbosa (1), A. C. Moraes (1), S. Hacon (2). (1) PETROBRAS, Rio de Janeiro, Brazil; (2) ,

P103-038A REVIEW OF THE MOST RELEVANT RESIDUES OF PHARMACEUTICALS PRODUCTS OF HUMAN USE IN EFFLUENTS AND SLUDGES FROM WASTE WATER TREATMENT PLANTS. S. Aguayo (1), A. De La Torre (2), M. Carballo (2), R. Cabrera (1), J. Méndez (1). (1) Centro Nacional de Sanidad Ambiental Instituto de Salud Carlos III, Majadahonda, Spain; (2) Centro de Investigación en Sanidad Animal. INIA, Spain

P103-039IN VITRO EFFECTS OF SUMMER AND WINTER MILAN PARTICULATE MATTER. M. Gualtieri (1), E. Longhin (1), E. Pezzolato (1), P. Mantecca (1), E. Molteni (1), J. Holme (2), M. Camatini (1). (1) Università Milano Bicocca, Milano, Italy; (2) Norwegian Institute of Public Health,, Oslo, Norway

P103-040DIFFERENTIAL EXPRESSION PROFILES OF MICRORNAS IN MICE INTERNALLY EXPOSED TO TRITIATED WATER. F. Cui, J. Tong, X. Sun, X. Ding. School of Radiation Medicine and Public Health,Suzhou University, Suzhou, China

P103-041ENVIRONMENTAL MONITORING OF PERSISTENT ORGANIC POLLUTANTS (POP). C. Turgut. Adnan Menderes University, Aydin, Turkey

P103-042LEAD HUMAN HEALTH RISK ASSESSMENT CASE STUDY: CASSITERITE MINING IN THE WESTERN BRAZILIAN AMAZON- BRAZIL. S. Hacon (1), C. Vega (1), B. Hacon

(1), D. P. D. Carvalho (2), R. Almeida (2), I. Bruno Barbosa (2), W. Bastos (2). (1) National Public Health School-FIOCRUZ, Rio de Janeiro, Brazil; (2) Universidade Federal de Rondonia, Porto Velho, Brazil

P103-043POLYBROMODIPHENYLETHERS EXPOSURE AND THYROID HORMONES IN QUEBEC PREGNANT WOMEN. M. E. Bourkou, N. Abdelouahab, L. Takser. Univérsité de Sherbrooke, Sherbrooke, Canada

P103-044LONG-TERM EXPOSURE TO MANGANESE: A CASE STUDY IN A MINING COMMUNITY IN THE WESTERN BRAZILIAN AMAZON. B. Hacon (1), S. Hacon (1), C. Vega (1), L. Viana (1), W. Bastos (2), D. Carvalho (2), R. Almeida (2), I. Barbosa De Holanda (2). (1) National Public Health School - FIOCRUZ, Rio de Janeiro, Brazil; (2) Universidade Federal de Rondonia, Porto Velho, Brazil

P103-045THE COMPATIBLE SOLUTE ECTOINE PREVENTS NEUTROPHILIC LUNG INFLAMMATION INDUCED BY ENVIRONMENTAL MODEL NANOPARTICLES IN VIVO. K. Unfried (1), U. Sydlik (1), H. Peuschel (1), C. Albrecht (1), A. Bilstein (2), J. Krutmann (1). (1) Institut für umweltmedizinische Forschung (IUF),, Düsseldorf, Germany; (2) bitop AG, Witten, Germany,

P103-051HEAVY METALS AND ESSENTIAL ELEMENTS IN BONES AND EGGS OF CHINSTRAP PENGUIN (PYGOSCELIS ANTARCTICA) FROM DECEPTION ISLAND, ANTARCTICA. S. Jerez (1), M. Motas (1), J. Benzal (2), A. Martínez (2), F. Valera (2), A. Barbosa (3). (1) University of Murcia, Murcia, Spain; (2) Estación Experimental de Zonas Áridas, CSIC, Spain; (3) Museo Nacional de Ciencias Naturales, CSIC, Spain

P103-052AN INTEGRATED CELLULAR DOSIMETRY AND STRUCTURE-PROPERTY RELATIONSHIP MODELING APPROACH TO CONDUCT IN VITRO-IN VIVO EXTRAPOLATION OF THE DOSE-RESPONSE RELATIONSHIP: A CASE STUDY WITH TOLUENE. T. Peyret, K. Krishnan. IRSPUM, Université de Montréal, Montréal, Canada

P103-061STUDIES ON HEALTH EFFECTS CAUSED BY VOC EMISSIONS FROM PINE WOOD (PINUS SPECIES) AND ORIENTED STRAND BOARDS IN HEALTHY VOLUNTEERS. R. Gminski (1), R. Marutzky (2), S. Kevekordes (1), F. Fuhrmann (2), W. Bürger (2), D. Hauschke (3), V. Mersch-Sundermann (1), T. Tang (1). (1) Department of Environmental Health Sciences, Freiburg University Medical Center, Freiburg, Germany, Freiburg, Germany; (2) Fraunhofer-Institut für Holzforschung - Wilhelm-Klauditz-Institut (WKI), Braunschweig, Germany; (3) Institut für Medizinische Biometrie, Universität Freiburg, Freiburg, Germany,

P104: OCCUPATIONAL TOXICOLOGY

P104-001MODULATION OF PHASE-II ENZYMES ACTIVITIES BY OVARIECTOMY IN LIVER AND KIDNEY OF BENZENE TREATED RATS. Y. Verma. C.C.S.University, Meerut, India

P104-002CANCER RISK ASSESSMENT FOR REFRACTORY CERAMIC FIBRES FROM AFSSET OCCUPATIONAL EXPOSURE LIMIT (OEL) COMMITTEE. M. El Yamani, H. Modelon. French Agency for Environmental and Occupational Health Safety, Maisons-Alfort cedex, France

P104-003DOSE-DEPENDENT NEUROLOGIC ABNORMALITIES IN WORKERS EXPOSED TO 1-BROMOPROPANE. G. Ichihara (1), W. Li (2), E. Shibata (3), Z. Zhou (2), S. Ichihara (4), H. Wang (1), Q. Wang (2), J. Li (2), L. Zhang (1), Y. Takeuchi (5), X. Ding (6). (1) Nagoya University Graduate School of Medicine, Nagoya, Japan; (2) Fudan University School of Public Health; (3)

Aichi Medical University; (4) Mie University; (5) Nagoya University; (6) Shanghai Institute of Planned Parenthood Research,


42

P104-004RISK ASSESSMENT IN OCCUPATIONAL EXPOSURE TO FORMALDEHYDE:DIFFERENCES BETWEEN ANATOMY AND PATHOLOGY LABORATORIES AND FORMALDEHYDE-RESINS PRODUCTION. S. Viegas (1), C. Ladeira (1), C. Nunes (2), J. Malta-Vacas (1), M. Gomes (1), M. Brito (1), J. Prista (2). (1) ESTeSL, Lisbon, Portugal; (2) ,

P104-006CHILD LABOR AND HEALTH: EXPLORATORY STUDY FROM A PUBLIC MARKET IN VALENCIA, VENEZUELA. M. Rojas (1), Z. Vegas (2), L. Briceno (3), L. Rodriguez (4). (1) MRM-Consultox & University of Carabobo, Valencia, Venezuela; (2) School of Bioanalysis-Univ. of Carabobo, Valencia, Venezuela; (3) University of Rosario. Bogota. Colombia, Bogota, Colombia; (4) School of Bioanalysis. Univ. of Carabobo, Valencia, Venezuela

P104-007HEALTH BASED OELS OF CHEMICALS IN POLAND IN 2009. M. Kupczewska Dobecka, S. Czerczak. Nofer Institute of Occupational Medicine in Poland, Łódź, Poland

P104-008THE EASE ESTIMATING OF OCCUPATIONAL INHALATION EXPOSURE TO THREE ORGANIC SOLVENTS: TOLUENE, ETHYL ACETATE AND ACETONE. S. Czerczak, M. Kupczewska Dobecka. Nofer Institute of Occupational Medicine in Poland, Łódź, Poland

P104-009HEALTH IMPAIRMENTS INDUCED BY OCCUPATIONAL AND ENVIRONMENTAL EXPOSURE TO EMERGING AND FORMER CONTAMINANTS. F. Deschamps. Department of occupationnal health, REIMS, France, Metropolitan

P104-010TOXIC RESPONSE OF THE RESPIRATORY SYSTEM AS A RESULT OF EXPOSURE TO HIGH CONCENTRATIONS OF WHEAT FLOUR DUST. M. Neghab, A. Soltanzadeh, A. Alipour. School of Health and Research Center for Health Sciences, Shiraz, Iran (Islamic Republic of)

P104-011TOXICITY OF DUSTS COLLECTED FROM SOUTH AFRICAN MINES: FREE-RADICAL PRODUCTION AND LIPID PEROXIDATION. M. Vetten (1), V. Vallyathan (2), S. S. Leonard (2), A. Kenyon (2), M. Gulumian (1). (1) National Institute of Occupational Health, Johannesburg, South Africa, Johannesburg, South Africa; (2) National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America

P104-012WORKPLACE EXPOSURES EQUIVALENT TO NO OR LOW OBSERVABLE ADVERSE EFFECT CONCENTRATIONS IN ANIMALS: STEP BY STEP APPROACH. A. Oller

(1), G. Oberdorster (2). (1) NiPERA, Inc, Durham, United States; (2) University of Rochester, Rochester, United States

P104-013PROTEOMIC ANALYSIS OF PRIMARY PORCINE BLADDER EPITHELIAL CELLS AFTER BAP EXPOSURE. N. Verma, A. W. Rettenmeier, S. Schmitz-Spanke. Universität Klinicum, Essen, Essen, Germany

P104-014EFFECTS OF PEAK CONCENTRATIONS ON THE NEUROTOXICITY OF STYRENE IN WORKERS. N. El Majidi, A. Vyskocil, R. Thuot, C. Beaudry, G. Charest-Tardif, R. Tardif, F. Gagnon, B. Ska, A. Turcot, C. Viau. Université de Montréal, Montréal, Canada

P104-015MEASUREMENT OF DNA DAMAGE WITH FPG/ENDO III FLARE ASSAY AND REAL TIME RT-PCR IN SD RATS EXPOSED TO CUMENE. S. J. Kim, K. T. Rim, S. B. Lee, H. Y. Kim. Korea Occupational Safety & Health Agency, Daejeon, Korea, Republic of

P104-016DIFFERENCE IN THE GENOTOXICITY OF CHRONIC INHALATION EXPOSURE TO ETHYL TERTIARY BUTYL ETHER IN SPERM BETWEEN ALDH2 WILD-TYPE AND ALDH2 KNOCKOUT MICE. Z. Weng, M. Suda, K. Ohtani, R. S. Wang. Japan National Institute of Occupational Safety and Health, Kawasaki, Japan

P104-017FOLLOW UP OF 2 PATIENTS WITH MESANGIAL IGA GLOMERULONEPHRITIS EXPOSED TO CADMIUM AND ORGANIC SOLVENTS. J. Fernandez (1), P. Sanz (2), S. Nogue (2). (1) Laboratorio de análisis Dr.Echevarne, BARCELONA, Spain; (2) Hospital Clinic, BARCELONA, Spain

P104-018IDENTIFICATION OF NOVEL INTERACTION PROTEINS OF SET IN TRICHLOROETHYLENE-TREATED L-02 LIVER CELLS. J. Liu, M. Chen, X. Yang, S. Fang, X. Xing, H. Huang, L. Zhou. Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Centre for Disease Control and Prevention, Shenzhen, China

P104-019DETERMINATION OF GSTM1 NULL GENOTYPE FROM BUCCAL SWABS SAMPLES IN WORKERS EXPOSED TO STYRENE. M. J. Prieto Castelló (1), A. Cardona Llorens

(1), L. Santulario Verdú (1), D. Marhuenda Amorós (1), A. Corno Caparrós (2), J. M. Roel Valdés (3). (1) Facultad de Medicina. Universidad Miguel Hernández., San Juan, Spain; (2) Laboratorio de Análisis Genéticos ANCOR, Alicante, Spain; (3) INVASSAT Alicante, Alicante, Spain

P104-020C-MYC RELATED SNP RS9642880[T], GSTM1 GENOTYPE AND OCCUPATIONAL EXPOSURE IN URINARY BLADDER CANCER CASES. K. Golka (1), M. Hermes (1), S. Selinski (1), M. Blaszkewicz (1), H. M. Bolt (1), G. Roth (2), H. Dietrich (2), H. M. Prager (3), K. Ickstadt (4), J. G. Hengstler (1). (1) Leibniz Research Centre for Working Environment and Human Factors (IfADo) at the TU Dortmund University, Dortmund, Germany; (2) Department of Urology, Paul Gerhardt Foundation, Lutherstadt Wittenberg; (3) Institute for Occupational, Social and Environmental Medicine, Castrop-Rauxel; (4) Faculty of Statistics, TU Dortmund University, Dortmund,

P104-021MODELING THE IMPACT OF WORKLOAD INTENSITY ON THE BIOLOGICAL EXPOSURE INDICATORS OF SOLVENTS. R. Tardif (1), G. Truchon (2), A. Bérubé (1), I. Sari-Minodier (3), G. Charest-Tardif (1). (1) DSEST-Université de Montréal, Montréal, Canada; (2) Institut de recherche Robert-Sauvé en santé et sécurité du travail, Montréal, Montréal, Canada; (3) AIX-Marseille Université, Marseille, France

P104-022BIOMONITORING OF RURAL WORKERS EXPOSED TO CHOLINESTERASE INHIBITOR INSECTICIDES IN BRAZIL. J. D. O. Pasiani, E. D. Caldas, J. R. C. V. Silva, P. Torres. Universidade de Brasília, Brasília, Brazil

P104-023DETERMINATION OF FORMIC ACID IN URINE OF WORKERS OCCUPATIONALLY EXPOSED TO FORMALDEHYDE. C. Mautempo, M. D. L. Bastos, F. Carvalho, F. Remião, H. Carmo, P. Guedes-De-Pinho. REQUIMTE, Department of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal

BARCELONAIUTOX 2010


43

P104-024GENOTOXIC EFFECTS OF OCCUPATIONAL EXPOSURE TO CHEMOTHERAPEUTIC AGENTS AMONG HEALTHCARE PERSONNEL AS REVEALED BY COMET ASSY IN THE PERIPHERAL BLOOD. K. Kyriakopoulou (1), E. Georgopoulou (2), C. Emmanouil (1), E. Vagka (2), E. Chatzaki (3), T. Constantinidis (4), K. Machera (1). (1) Laboratory of Pesticides Toxicology, Benaki Phytopathological Institute, Kifissia, Greece; (2) Program of Postgraduate Studies Health and Safety in Workplaces, Democritus University of Thrace, Alexandroupolis, Greece; (3) Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece; (4) Laboratory of Hygiene and Environmental Protection, Medical School, Democritus University of Thrace, Alexandroupolis, Greece

P104-025GSTM1 POLYMORPHISM ASSOCIATED WITH THE FORMATION OF ACRYLAMIDE-MERCAPTURIC ACIDS IN ACRYLAMIDE-EXPOSED WORKS. K. Y. Wu (1), N. Y. F. Huang (2), M. L. Chen (2), S. N. Uang (3), S. H. Liou (4), M. F. Chen (4). (1) National Taiwan University, Taipei, Taiwan; (2) National Yang-Ming University, Taipei, Taiwan; (3) Institute of Occupational Safety and Health, Taiwan; (4) National Health Research Institutes, Zhunan, Miao-Li County, Taiwan

P104-026TOXIC EFFECTS OF ETHYL TERTIARY BUTYL ETHER EXPOSURE AS MODIFIED BY ALDH2 GENE IN MICE. R. S. Wang, K. Ohtani, M. Suda, Z. Weng. Japan National Institute of Occupational Safety and Health, Kawasaki, Japan

P104-027FORMALDEHYDE OCCUPATIONAL EXPOSURE: GENOTOXIC EVALUATION. S. Costa (1), S. Silva (1), C. Costa (1), P. Coelho (1), C. Pina (1), J. Gaspar (2), A. Tavares (3), J. P. Teixeira(1). (1) National Institute of Health,Porto, Portugal, Vila Nova de Gaia, Portugal; (2) Faculty of Medical Sciences UNL, Lisbon, Portugal; (3) Regional Health Administration, Lisbon and Tagus Valley Health Authority

P104-028ASSESSMENT OF ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE IN OCCUPATIONAL EXPOSURE OF TEMEPHOS IN FLORIANOPOLIS, SOUTH BRAZIL. C. R. Dos Santos, A. M. Cardozo, T. M. Ávila, C. M. C. Leite, R. I. Prim. University of Santa Catarina, Florianopolis, Brazil

P104-029EFFICACY OF SETS OF PERSONAL PROTECTIVE CLOTHING USED IN APPLICATIONS OF PESTICIDES IN SUGAR CANE AND CITRUS CROPS AND JUST WASHED IN THE LABORATORY. M. Espanhol, J. Gonçalves Machado Neto, A. C. Coleone, A. A. Machado, L. A. Sizuki Nociti, G. França Gomes De Carvalho. Faculty of Agrarian and Veterinarian Sciences,, Jaboticabal, Brazil

P104-030CORRELATION BETWEEN ENVIRONMENTAL LEVELS OF MERCURY IN BIOLOGICAL INDICATORS AND EXPOSED WORKERS IN A GOLD REFINERY. S. Fiestas Cruzado. Minera Yanacocha SRL, Cajamarca, Peru

P104-031INFLUENCE OF GENETIC POLYMORPHISM OF METABOLIZING ENZYMES OF POLYCYCLIC AROMATIC HYDROCARBONS IN EXCRETION OF 1-HYDROXIPIRENE AND COTININE BY OCCUPATIONAL EXPOSURE. T. Georgieva (1), T. Panev (1), B. Dragova (2), V. Nikolova (1), D. Chohadjieva (1), T. Popov (1), S. Garte (3). (1) National Center of Public Health Protection, Sofia, Bulgaria; (2) Sofia Medical Univeristy; (3) Genetics Research Institute, Milan, Italy

P104-032ASSESSMENT OF MICRONUCLEUS FREQUENCIES IN LYMPHOCYTES OF WORKERS EXPOSED TO FUMES OF BITUMEN – RESULTS OF THE HUMAN BITUMEN STUDY. P. Welge, B. Marczynski, M. Raulf-Heimsoth, A. Spickenheuer, B. Kendzia, E. Heinze, A. Erkes, M. Hagnia, H. U. Käfferlein, B. Pesch, T. Brüning. Institute for Prevention and Occupational Medicine of the German Social Accident Insurance - Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany

P104-033HYDROFLUORIC ACID (HF) BURN INJURIES DECONTAMINATION IN EX VIVO HUMAN EYE AND SKIN MODELS. L. Mathieu (1), E. Lati (2), F. Burgher (1), C. Fosse (1), P. Gasser (2), A. Hall (3), L. Peno-Mazzarino (2), N. Schrage (4). (1) Prevor Laboratory, Valmondois, France, Valmondois, France; (2) BIO EC Laboratory, Longjumeau, France, Longjumeau, France; (3) Colorado School of Public Health, Denver, Colorado, USA, Laramie, United States; (4) Aachen Centre of Technology Transfer in Ophthalmology, Aachen, Germany, Aachen, Germany

P104-034SELECTION OF BIOMARKERS TO INVESTIGATE THE PROTECTION EFFECT OF N-ACETYLCYSTEINE ON 2,5-HEXANEDIONE NEUROTOXICITY IN RATS EXPOSED TO 2,5-HEXANEDIONE. M. E. Torres (1), L. Gonçalves (2), A. P. Dos Santos (1), M. C. Batoréu (1), M. L. Mateus (1). (1) Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Lisbon, Portugal; (2) Center for Interdisciplinary Research Egas Moniz (CiiEM), Almada, Portugal

P104-035GENDER ANALYSIS IN OCCUPATIONAL POISONINGS IN SPAIN. M. E. Rodríguez (1), V. Uroz (1), S. Nogué (2), B. Climent (3), J. Puiguriguer (4), M. S. Dorado (5), S. Mateo (1), Á. Nieto

(1), M. J. Anadón (1). (1) Universidad Complutense de Madrid., MADRID, Spain; (2) Hospital Clínico y Provincial, Barcelona., BARCELONA, Spain; (3) Hospital General Universitario, Valencia., VALENCIA, Spain; (4) Hospital Son Dureta, Mallorca., PALMA DE MALLORCA, Spain; (5) Hospital 12 de Octubre, Madrid., MADRID, Spain

P104-036OCCUPATIONAL EXPOSURE OF MINERS TO MANGANESE AND LEAD - A PRELIMINARY STUDY. A. P. Marreilha Dos Santos (1), V. Andrade (1), M. L. Mateus (1), M. Aschner (2), M. C. Batoréu (1). (1) i.Med-UL, Faculty of Pharmacy, University of Lisbon, Lisbon. Portugal, Lisbon, Portugal; (2) Department of Pediatrics, Vanderbilt University Medical Center, TN, USA,

P104-037BIOMARKER END-POINTS IN OCCUPATIONAL EXPOSURE TO ANTINEOPLASTIC DRUGS. A. Colacci (1), S. Perdichizzi (1), P. Silingardi (1), M. C. Nucci (2), M. Vaccari (1), A. Barbieri (3), C. Bolognesi (4), M. G. Mascolo (1), F. S. Violante (3), S. Grilli (5), E. Morandi (1). (1) Environmental Protection and Health Prevention Agency, Emilia-Romagna, Italy, Bologna, Italy; (2) Occupational Health Unit, Sant’Orsola-Malpighi Hospital, Bologna, Italy; (3) Occupational Medicine Unit, University of Bologna, Sant’Orsola-Malpighi Hospital, Bologna, Italy; (4) Environmental Carcinogenesis Unit National Institute for Cancer Research (IST) – Genoa, Italy; (5) Dept. Experimental Pathology, Cancer Research Section, Bologna University Medical School,

P104-045POLYCYCLIC AROMATIC HYDROCARBONS IN ATMOSPHERIC PARTICULATE MATTER (PM2.5) IN THE ARARAQUARA CITY (SE, BRAZIL): INFLUENCE OF SUGAR CANE BURNING ON POTENTIAL CANCER RISKF. S. Silva (1), J. Cristale (1), P. H. N. Saldiva (2), M. R. R. Marchi (1). (1) Institute of Chemistry, Unesp – Univ. Estadual Paulista, Araraquara, Brazil; (2) Faculty of Medicine, USP - University of Sao Paulo,

P104-051POLYNEUROPATHIES ASSOCIATED WITH THE USE OF PESTICIDES. T. Parron (1), R. Alarcon (2), M. D. M. Requena (1), A. Hernandez (3), A. Pla (3). (1) Delegacion Provincial de Salud de Almeria, Almeria, Spain; (2) Universidad de Almeria, Spain; (3) Universidad de Granada, Spain


44

P105: HUMAN CLINICAL TOXICOLOGY

P105-001TRAMADOL POISONING INDUCED SEIZURE. O. Mehrpour (1), F. Taghaddosi-Nejad (2), A. Seghatoleslami (2), N. Chalaki (1), R. Afshari (2). (1) Birjand university of Medical sciences, Birjand, Iran (Islamic Republic of); (2) ,

P105-002CLINICAL PRESENTATIONS OF OPIUM POISONING IN INFANTS. N. Zamani (1), H. Sanaei-Zadeh (1), B. Mostafazadeh (2). (1) Rasoul Akram Hospital, Tehran, Iran (Islamic Republic of); (2) ,

P105-003SODIUM BICARBONATE INFUSION VERSUS BOLUS IN TRICYCLIC ANTIDEPRESSANT POISONING. H. Talaie, B. Mostafazadeh, A. Mahdavinejad, R. Panahandeh. Toxicological research center, Tehran, Iran (Islamic Republic of)

P105-004A RETROSPECTIVE 7-YEARS STUDY OF ALUMINUM PHOSPHIDE POISONING IN TEHRAN. G. Sasanian (1), S. Shadnia (2), M. Abdollahi (1), P. Allami (2), A. Hosseini (1), A. Ranjbar (1), N. Amini-Shirazi (1). (1) Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of); (2) Loghman Hakim Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences,

P105-005DELAYED TOXIC EFFECTS OF SULFUR MUSTARD ON UPPER AND LOWER RESPIRATORY TRACTS IN IRANIAN VETERANS. M. Balali-Mood, H. Kahrom, R. Afshari, D. Attaran, R. Zojaji, M. Kamrani. Medical Toxicology Research Center, Mashhad, Iran (Islamic Republic of)

P105-006INVESTIGATION ON MORTALITY AFTER CORROSIVE INGESTION: A PROSPECTIVE STUDY. H. Peyvandi, R. Yeganeh. Loghman Hakim Hospital, Shaheed, Tehran, Iran (Islamic Republic of)

P105-007DIMETHOATE-INDUCED OXIDATIVE STRESS IN HUMAN ERYTHROCYTES AND THE PROTECTIVE EFFECT OF VITAMINS C AND E IN VITRO. F. Ben Abdallah, B. Gargouri, S. Lassoued, L. Ammar-Keskes. Higher Institute of Biotechnology of Sfax, Sfax, Tunisia

P105-008REPETITIVE NERVE STIMULATION IS AN IMPORTANT TOOL FOR CONFIRMATION OF INTERMEDIATE SYNDROME. S. Vučinić (1), B. Antonijević (2), T. Ilić (1), J. Jović-Stošić

(1), G. Babić (1), M. Ćurčić (2), R. Ilić (1). (1) Military Medical Academy, Belgrade, Serbia; (2) Faculty of Farmacy, Belgrade, Serbia

P105-009HYDROXYZINE OVERDOSE WITH POSSIBLE CARDIAC TOXICITY. D. H. Phua (1), S. H. Ang (2). (1) Tan Tock Seng Hospital, Singapore, Singapore; (2) , Brunei Darussalam

P105-010OCCUPATIONAL EXPOSURE TO LOW LEVELS OF BENZENE: BIOMARKERS OF EXPOSURE, EFFECT AND SUSCEPTIBILITY. M. E. Fracasso (1), D. Doria (1), M. Carrieri (2), G. B. Bartolucci (2), G. Spatari (3), M. Manno (4). (1) University of Verona, Verona, Italy; (2) University of Padova, Padova, Italy; (3) University of Messina, Italy; (4) University of Napoli, Italy

P105-011ANALYSIS OF Y CHROMOSOME MICRODELETION AND ALTERED SPERM QUALITY IN SUBJECTS EXPOSED TO HEXACHLOROCYCLOHEXANE (HCH). F. H. Khan, P. Ganesan, S. Kumar. University of Lucknow, Lucknow, India

P105-012NATIONAL POISON CONTROL CENTRE IN SERBIA: CURRENT ACTIVITIES AND CHALLENGES. J. Jovic-Stosic, S. Vucinic, G. Babic, T. Rezic, O. Potrebic. National Poison Control Centre, Military Medical Academy, Belgrade, Serbia, Belgrade, Serbia

P105-013THE EPIDEMIOLOGYIC STUDY OF SUICIDE IN NORTH WEST OF IRAN. E. Farzaneh (1), I. Sayadrezai (1), F. Nasl Seraji (1), B. Mostafazadeh (2). (1) Ardabil university of medical sciences, Ardabil,Iran., ardabil, Iran (Islamic Republic of); (2) logman poison center,Shahid Beheshti university of medical sciences,Tehran, Iran, tehran, Iran (Islamic Republic of)

P105-014BECLIN1 IS RESPONSIBLE FOR INDUCTION OF AUTOPHAGY THROUGH CONTROLLING RADIATION-INDUCED OSTEOPONTIN IN HUMAN LUNG CANCER CELLS. S. H. Chang (1), A. Minai-Tehrani (2), H. T. Lim (1), J. Y. Shin (2), S. J. Park (2), J. E. Kim (1), H. J. Sung (3), C. O. Yun (4), K. H. Lee (5), G. R. J. Beck (6), M. H. Cho (7). (1) Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University & Nano Systems Institute-National Core Research Center, Seoul, Korea, Republic of; (2) Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University; (3) Institute of Fusion Technology, Hoseo University; (4) Institute for Cancer Research, Yonsei University School of Medicine; (5) Laboratory of Radiation Molecular Oncology, Korea Institute of Radiological & Medical Sciences; (6) Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, United States; (7) Laboratory of Toxicology, College of Veterinary Medicine & Nano Systems Institute-National Core Research Center & Graduate School of Convergence Science, Seoul National University,

P105-015FATAL INTOXICATIONS BY SUDDEN HYDROGEN SULFIDE EMISSION IN UNCONFINED SPACES. S. Nogue (1), R. Pou (2), J. Fernandez (3), P. Sanz (1). (1) HOSPITAL CLINIC, BARCELONA, Spain; (2) SGS-TECNOS, BARCELONA, Spain; (3) Laboratorio de análisis Dr.Echevarne, BARCELONA, Spain

P105-016THE EFFECT OF CHEMOTHERAPY ON OXIDANT AND ANTIOXIDANT PARAMETERS IN BONE MARROW TRANSPLANTATION PATIENTS. S. Sabuncuoglu (1), H. Ozgunes (1), D. Uckan Cetinkaya (2). (1) Hacettepe University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey; (2) Hacettepe University, Faculty of Medicine, Department of Pediatrics, Turkey

P105-017THERAPEUTIC EFFECTS OF SODIUM BICARBONATE IN ORGANOPHOSPHATE POISONING IN MAN IS PH DEPENDENT; A RANDOMIZED CLINICAL TRIAL. R. Afshari, M. Mohammadi, M. Balali-Mood. Mashhad University of Medical Sciences, Mashhad, Iran (Islamic Republic of)

P105-018EFFECTIVENESS OF CALCIUM DISODIUM VERSENATE CHELATION THERAPY ON CHRONIC LEAD INTOXICATION. T. Soylemezoglu (1), M. Odabaşı (1), H. Yılmaz (2), G. Mergen (1), Z. Kayaaltı (1). (1) Ankara University Institute of Forensic Medicine, Ankara, Turkey; (2) Occupational Diseases Hospital Ankara, TURKEY,

P105-019PLASMA MDA LEVELS, GSH-PX ACTIVITIES AND NITRITE/NITRATE LEVELS IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER. A. Sayal (1), A. Tüzün (1), B. Değertekin (1), Z. Yeşilova (1), İ. Naharcı (1), A. Eken (1), A. Aydın (1), A. Özgök (2), A. Uygun (1). (1) Gülhane Military Medical Academy, Ankara, Turkey, ANKARA, Turkey; (2) , Turkey

BARCELONAIUTOX 2010


45

P105-020PLASMA NITRITE/NITRATE CONCENTRATIONS IN INTRAUTERINE GROWTH RESTRICTED PREGNANCIES. C. Akay (1), A. Yeter (2), N. Danışman (2), A. Eken (1), O. Erdem

(1), A. Sayal (1), A. Özgök (2), A. Aydın (1). (1) Gülhane Military Medical Academy, Ankara, Turkey, ANKARA, Turkey; (2) , Turkey

P105-021CLINICAL MANIFESTATIONS OF LEAD LEVELS IN CHILDREN WITH PARA-OCCUPATIONAL EXPOSURE TO AUTOMOBILE BATTERY RECYCLING PROCESSES IN SOACHA AND BOGOTÁ (COLOMBIA). M. Gutiérrez, C. M. Hurtado, J. Echeverry. Universidad Nacional de Colombia, Bogotá, Colombia

P105-022Identification Of Potential Biomarkers Of Pris (Propofol Infusion Syndrome): A Prospective Study. R. Calé (1), P. Guedes-De-Pinho (1), I. Aragão (2), H. Martins (3), G. Cardoso

(2), M. Duran (4), R. Wanders (4), M. Silva (5), L. Ferreira (6), P. Branco (6), M. D. L. Bastos (1).(1) Department of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal; (2) UCIP, Hospital, Santo António, Porto; (3) Chemical Laboratory, Hospital de Santo António, Porto, Portugal; (4) Academic Medical Center, University of Amsterdam, The Netherlands; (5) iMED.UL - CPM, Faculty of Pharmacy, University of Lisbon; (6) REQUIMTE, Department of Chemistry, Faculty of Science and Technology, University of Nova de Lisboa,

P105-023ACUTE TOXICITY OF DIEPOXYBUTANE TO MONONUCLEAR LEUKOCYTES. MULTIFACTORIAL MECHANISMS? F. Ponte (1), F. Carvalho (1), B. Porto (2). (1) Faculty of Pharmacy, University of Porto, Porto, Portugal; (2) Institute of Biomedical Sciences Abel Salazar, University of Porto,

P105-024ACUTE ALUMINUM PHOSPHIDE POISONING: 5 YEARS EXPERIENCE. E. Behravan, M. Ghorbani, R. Afshari. Mashhad univ.of medical science, Mashhad, Iran (Islamic Republic of)

P105-025THE EFFICACY AND THE TOLERABILITY OF PREGABALIN IN THE CASE OF ADULTS PATIENTS WITH GENERALISED ANXIETY DISORDERS. D. Ionescu (1), C. Dehelean

(1), S. Funar Timofei (2), S. Dragan (1), E. Galca (3), R. Dumache (1). (1) University of Medicine and Pharmacy Victor Babes, Timisoara, Romania; (2) Institute of Chemistry, Romanian Academy, Timisoara, Romania; (3) Psychiatry Department, Municipal Hospital, Timisoara, Romania

P105-026IRON POISONING IN CHILDREN -A RARE ENTITY. V. G. Nitescu, C. Ulmeanu. Pediatric Poisoning Center Grigore Alexandrescu Hospital, Bucharest, Romania

P105-027EFFECTS OF PASSIVE SMOKING ON ACTIVE AND RESTING HUMANS 0, 1, AND 3 HOURS FOLLOWING EXPOSURE. A. Flouris (1), G. Metsios (1), A. Carrillo (1), A. Jamurtas (1), I. Terzi (2), M. Tzatzarakis (2), A. Tsatsakis (2), Y. Koutedakis (1). (1) Centre for Research and Technology Thessaly, Trikala, Greece; (2) Medical School, University of Crete, Heraklion, Greece

P105-028ACUTE EXPOSURE TO SECONDHAND SMOKE IS ASSOCIATED WITH ENDOGENOUS LUNG ACIDOSIS AND OBSTRUCTIVE PULMONARY DISORDER. P. Dinas (1), A. Flouris (1), M. Minas (2), K. Kostikas (2), I. Mavromanolaki (1), I. Terzi (3), M. Kavvalakis (3), M. Tzatzarakis (3), A. Tsatsakis (3). (1) Centre for Research and Technology Thessaly, Trikala, Greece; (2) University of Thessaly, Larisa, Greece; (3) Medical School, University of Crete,

P105-029SIDE EFFECTS OF PHARMACEUTICALS FOR NERVOUS SYSTEM TREATMENT DISORDERS. G. Font, B. Roman, M. J. Ruiz. University of Valencia, Burjassot, Spain

P105-030INTERACTION BETWEEN R AND S ENANTIOMERS OF METHADONE AND ISONIAZID: A CASE STUDY. M. C. Pellin (1), J. Barril (1), C. Gimeno (2), E. Mora (2), J. Esteban (1). (1Universidad Miguel Hernandez de Elche, Elche, Spain; (2) UCA de La Vila Joiosa Departamento 16 (Alicante).,

P105-031METFORMIN-RELATED LACTIC ACIDOSIS: A CASE SERIES. C. A. Locatelli (1), S. Vecchio (1), S. Bigi (1), V. M. Petrolini (1), A. Giampreti (1), D. Lonati (1), L. Rocchi (2), A. Valli (2), P. Papa (2), L. Manzo (3). (1) Pavia Poison Centre - National Toxicology Information Centre, IRCCS Maugeri Foundation Hospital, Pavia, Italy, Pavia, Italy; (2) Laboratory of Analytical Toxicology, Clinical Chemistry Service, IRCCS Policlinico San Matteo Foundation, Pavia, Italy; (3) Medical Toxicology, Department of Internal Medicine and Therapeutics, University of Pavia, Italy,

P105-032INFLUENCE OF HUMAN IMMUNODEFICIENCY VIRUS AND HEPATITIS C VIRUS INFECTIONS ON METHADONE PHARMACOLOGICAL VARIABLES. J. Esteban (1), J. Barril (1), C. Gimeno (2), E. Mora (2), M. C. Pellin (1). (1) Universidad Miguel Hernandez de Elche, Elche, Spain; (2) UCA de La Vila Joiosa Departamento 16, Alicante, Spain

P105-033REFINEMENTS IN LOXOSCELISM TREATMENT. D. Rodriguez Alvarez, C. Sanchez Villegas. Hospital General Centro Medico La Raza, Ciudad de Mexico, Mexico

P105-034POSONINGS WITH STREET-DRUGS DURING THE PERIOD 1993-2008. M. Kotwica. Institute of Occupational Medicine, Lodz, Poland

P105-035A COMPARATIVE STUDY IN MICE OF TOLERANCE TO MORPHINE ANALGESIC AND RESPIRATORY EFFECTS: MECHANISMS AND CONSEQUENCES. B. Mégarbane, H. Al-Haddad, W. Mohammad, N. Marie, F. Noble, F. J. Baud. INSERM U705, Hôpital Lariboisière, Université Paris-Diderot, Paris, France P105-036OUTCOME IN 157 ALPHA-AMANITIN-POISONED PATIENTS TREATED WITH THE “PAVIA PROTOCOL”. C. A. Locatelli, V. M. Petrolini, S. Vecchio, S. Bigi, D. Lonati, A. Giampreti, T. Coccini, E. Roda, D. Acerbi, L. Manzo. Pavia Poison Centre - National Toxicology Information Centre, IRCCS Maugeri Foundation Hospital, Pavia, Italy, Pavia, Italy

P105-037QT-INTERVAL PROLONGATION IN PEDIATRIC PATIENTS AFTER OXATOMIDE OVERDOSE. V. M. Petrolini (1), S. Vecchio (1), C. A. Locatelli (1), M. G. Contessa (2), A. Giampreti (1), D. Lonati (1), S. Bigi (1), C. Rognoni (1), L. Manzo (1). (1) Pavia Poison Centre - National Toxicology Information Centre, IRCCS Maugeri Foundation Hospital, Pavia, Italy, Pavia, Italy; (2)

Department of Physiology and Pharmacology, La Sapienza University, Roma, Italy,

P105-038ITALIAN VIPER VENOM NEUROTOXICITY: CLINICAL AND EXPERIMENTAL DATA. C. A. Locatelli (1), D. Lonati (1), O. Rossetto (2), M. Cintra-Francischinelli (2), A. Giampreti (1), S. Vecchio (1), V. M. Petrolini (1), A. Gentilli (3), L. Manzo (4), C. Montecucco (2). (1) Pavia Poison Centre - National Toxicology Information Centre, IRCCS Maugeri Foundation Hospital, Pavia, Italy, Pavia, Italy; (2) Department of Biomedical Sciences, University of Padova, Italy; (3) Department of Animal Biology, University of Pavia, Italy; (4) Department of Internal Medicine and Therapeutics, University of Pavia, Italy,


46

P105-039RELEASE OF HEAVY METALS FROM RETAINED LEAD PROJECTILES AND THERMOMETER´S MERCURY. C. A. Locatelli (1), A. Giampreti (1), D. Lonati (1), S. Bigi (1), S. Vecchio (1), V. M. Petrolini (1), L. Manzo (2), A. Pellicciotti (3), D. C. Pezzola (4). (1) Pavia Poison Centre - National Toxicology Information Centre, IRCCS Maugeri Foundation Hospital, Pavia, Italy, Pavia, Italy; (2) Medical Toxicology, Department of Internal Medicine and Therapeutics, University of Pavia, Italy; (3) Department of General Surgery, Acquapendente Hospital, ASL Viterbo, Italy; (4) Department of General Surgery, Ospedali Civili of Brescia, Italy,

P105-040CAUSALITY ASSESSMENT FÜR HEPATOTOXICITY - NECESSITIES AND REALITIES. J. Schulze, X. Glass. Office of the Dean, Frankfurt/Main, Germany

P105-041SURVEY ON CLINICIANS´ OPINION ON THE IMPORTANCE OF LABORATORY TESTS. B. Castanyer (1), B. Barcelo (1), J. Puiguriguer (1), A. R. Pons (1), C. Yates (1), S. Nogue (2). (1) Hospital Universitari Son Dureta, Palma, Spain; (2) Hospital Clinic Barcelona,

P105-042GC/MS SCREENING AS A USEFUL TOOL IN THE ANALYTICAL DIAGNOSIS OF ACUTE POISONING IN THE EMERGENCY DEPARTMENTS. S. Menao Guillen, A. Ferrer-Dufol, M. Arruebo Muñio, M. Ramos Alvarez, M. Arevalo Duran. HCU Lozano Blesa. Zaragoza. Spain

P105-046ECG AS A PROGNOSTIC INDEX IN ACUTE SEVERE ORGANOPHOSPHATE POISONING. S. Shadnia (1), A. Okazi (1), N. Akhlaghi (1), G. Sasanian (2), M. Abdollahi (2). (1) Loghman Hakim Hospital Poison Center, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran (Islamic Republic of); (2) Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences,

P105-055SUBSTANCE- P LEVEL IN THE SERUM OF CHEMICAL VICTIMS OF MUSTARD GAS. M. Shohrati, M. Chanei, S. Mahyar. Baqiyatallah University of Medical Sciences, Tehran, Iran (Islamic Republic of)

P105-059PRONOSTIC FACTORS FOR PERSISTENT HEPATIC DAMAGE IN CHILDREN LESS THAN 5 YEARS OLD POISONING BY ACETAMINOPHEN. P. Escalante Galindo.Hospital Juárez de México, Secretaria de Salud, México City, Mexico

P105-061DETERMINATION OF ORGANOCHLORINE PESTICIDES IN MATERNAL MILK FROM RESIDENT MOTHERS IN AGRICULTURAL POPULATIONS OF THE MÉRIDA STATE, VENEZUELA. J. Uzcátegui, N. Estebanez, S. González, A. Bagi. Universidad de los Andes, Mérida, Venezuela

P105-064DETERMINATION OF ORGANOCHLORINE PESTICIDES IN HUMAN BLOOD OF INHABITANTS OF AN ANDEAN POPULATION OF HIGH AGRICULTURAL PRODUCTION IN MÉRIDA, VENEZUELA. J. Uzcátegui, G. Biscardi, M. Valero, M. Torres, S. González. Universidad de Los Andes, Mérida, Venezuela

P105-070ANESTHESIOLOGIST´S APTITUDE FOR PRE-OPERATIVE DETECTION AND TREATMENT OF LATEX ALLERGY. S. A. Franco Chávez (1), C. Cabrera Pivaral (1), C. M. D. L. Preciado Serrano (1), O. Peña Ortiz (2). (1) Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco México, (2) Centro Universitario de Ciencias Exactas e Ingenieras; Universidad de Guadalajara, Jalisco México.

P105-071SAFETY PRECLINICAL EVALUATION FOR HEBERPROT P. A NEW THERAPEUTIC ALTERNATIVE FOR THE TREATMENT OF PATIENTS WITH DIABETIC FOOT ULCER. K. Cosme, D. Bacardí, J. Suárez, D. Berlanga, L. Aldana, C. Valenzuela, L. Hernández, J. Berlanga, R. Silva, L. Herrera. Universidad de la Havana, Cuba

P105-072IS FUNDAMENTAL RESEARCH IN TOXICOLOGY TRANSLATED INTO CLINICAL PRACTICE? P. J. Meier-Abt. University of Basel, Basel, Switzerland

P106: REGULATORY AND RISK ASSESSMENT

P106-001PROBLEMS OF PESTICIDE/ CHEMICAL REGULATIONS IN DEVELOPING COUNTRIES. A. Mahdavi. University of Tehran, Tehran, Iran (Islamic Republic of)

P106-002TOXICITY ASSESSMENT OF THE AQUEOUS EXTRACT OF CALOTROPIS PROCERA IN RABBITS. D. M. Jato (1), A. Zainab (2), S. David (3), P. Okewole (3), A. Aliyu (3), K. A. Jacob (4). (1) UNIVERSITY OF YAOUNDE I, YAOUNDE, Cameroon; (2) Ahmadou Bello University, Zaria, Nigeria; (3) National Veterinary Research Institute, Jos, Nigeria; (4) University of Ghana, Legon, Legon, Ghana

P106-003TOXICOLOGICAL EVALUATION OF MANGIFERA INDICA L. EXTRACT (VIMANG), A NEW CUBAN PRODUCT WITH ANTIOXIDANT PROPERTIES. I. Rodeiro Guerra (1), G. Garrido Garrido (2), J. Morffi Figueredo (3), J. E. Gonzalez Mesa (3), I. Hernández Balmaseda (1), A. Nuñes Selles (2), R. Delgado Hernández (2). (1) Center of Marine Bioproducts, Havana, Cuba; (2) Center of Pharmaceutical Chemistry; (3) Institute of Pharmacy and Food, Havana University,

P106-004RISK ASSESSMENT MODEL FOR ESTABLISHING HEAVY METAL LIMITS IN HEALTH SUPPLEMENTS. C. Butryee (1), P. Intaraluk (2), G. Mao (3). (1) Institute of Nutrition, Mahidol University, Salaya, Thailand; (2) Food Control Division, Food and Drug Administration, Muang, Thailand; (3) Technical Regulatory Affairs, Nutrilite, United States

P106-005SOME SCIENTIFIC, REGULATORY AND ETHICAL CONSIDREATIONS FOR INCREASING EFFICENCY IN PLANNING NON-HUMAN PRIMATE TOXICOLOGICAL STUDIES OF PHARMACEUTICALS. A. Casacó, I. Beausoleil, B. González. Center for Molecular Immunology, Playa, Cuba

P106-006TWO DIMENSIONAL VIEW OF HEALTH RISK STRATIFICATION ASSOCIATED WITH INHALATION EXPOSURE TO CHEMICALS RELEASED FROM PETROLEUM WASTE. Z. Fiala (1), D. Pelikanova (2), L. Borska (1), T. Borsky (3), A. Vyskocil (4), V. Krajak (5), J. Baudysova (6). (1) Charles University, Faculty of Medicine, Hradec Kralove, Czech Republic, Hradec Kralove, Czech Republic; (2) Empla Hradec Kralove Ltd., Hradec Kralove, Czech Republic; (3) Medtec-VOP Ltd., Hradec Kralove, Czech Republic; (4) University of Montreal, Montreal, Canada; (5) Regional Hygienic Institute, Hradec Kralove, Czech Republic; (6) University Hospital, Hradec Kralove, Czech Republic.

BARCELONAIUTOX 2010


47

P106-007HEALTH RISK EVALUATION OF EXPOSURE TO MIXTURE OF SUBSTANCES IN VARIOUS WORKPLACES. T. Borsky (1), Z. Fiala (2), A. Vyskocil (3), L. Borska (2), D. Drolet (4), F. Lemay (3), J. Kremlacek (2), V. Krajak (5), D. Ranna (6). (1) Medtec-VOP Ltd., Hradec Kralove, Czech Republic, Hradec Králové, Czech Republic; (2) Charles University, Faculty of Medicine, Hradec Kralove, Czech Republic; (3) University of Montreal, Montreal, Canada; (4) IRSST, Montreal, Canada; (5) Regional Hygienic Institute, Hradec Kralove, Czech Republic; (6) University Hospital, Hradec Kralove, Czech Republic.

P106-008DEVELOPMENT AND APPLICATION OF A RISK ASSESSMENT PARADIGM FOR ACROLEIN: A TOBACCO SMOKE CONSTITUENT. F. Cunningham, C. Meredith. British American Tobacco, Southampton, United Kingdom

P106-009JACVAM´S ROLE ON NEW ALTERNATIVES TO ANIMAL TESTING AND INTERNATIONAL HARMONIZATION. H. Kojima, T. Inoe, Y. Ohno. National Institute of Health Sciences, Tokyo, Japan

P106-010THE DOUBLE VALUE OF TOXICOKINETICS: IMPROVED CHEMICAL HAZARD AND RISK ASSESSMENT PLUS REDUCTION AND REFINEMENT OF ANIMAL USE. K. Travis (1), M. Bartels (2), R. Billington (3), W. Davies (4), M. Dent (5), G. Hawksworth (6), S. Parry (7), S. Saghir (2), S. Creton (8). (1) Syngenta, Bracknell, United Kingdom; (2) Dow Chemical, United Kingdom; (3) Dow Agrosciences, United Kingdom; (4) Huntingdon Life Sciences, United Kingdom; (5) Unilever, United Kingdom; (6) University Of Aberdeen, United Kingdom; (7)

Glaxosmithkline, United Kingdom; (8) National Centre For The Replacement, Refinement And Reduction Of Animals In Research (NC3Rs), United Kingdom.

P106-011EVALUATION OF THE TOXICITY/PATHOGENICITY OF A NEW FORMULATION OF THE BIOLARVICIDE BACTIVEC IN RATS USING DIFFERENT ROUTES OF EXPOSITION. A. Mancebo (1), T. Molier (2), B. González (1), S. Lugo (1), L. Riera (1), M. E. Arteaga (1), A. M. Bada (1), Y. González (1), M. Pupo (1), Y. Hernández (1), C. González (1). (1) CENPALAB, Ciudad Habana, Cuba; (2) LABIOFAM.

P106-012NON-INVASIVE BLOOD PRESSURE MONITORING IN AMBULATORY BEAGLE DOGS. A. M. Bétat (1), J. G. Napoléoni (2), A. Simonnard (1), R. Forster (1). (1) CIT, Evreux, France; (2) EMKA Technologies, Paris, France.

P106-013CIRCADIAN CYCLES IN CARDIOVASCULAR PARAMETERS IN MONKEYS, DOGS AND MINIPIGS. R. Forster, A. M. Bétat, A. Simonnard. CIT, Evreux, France

P106-014CHRONIC ORAL TOXICITY OF TANNIN POWDERS OBTAINED FROM BARK OF PINUS CARIBAEA MORELET IN RATS. A. M. Bada (1), J. L. Santana (2), B. González (1), Y. González (1), C. González (1), M. E. Arteaga (1), D. Gómez (1), A. Mancebo (1). (1) CENPALAB, Ciudad Habana, Cuba; (2) InsTEC.

P106-015SENSITIVITY ANALYSIS OF PBPK MODELS. G. Loizou, K. Mcnally. Health and Safety Laboratory, Buxton, United Kingdom

P106-016PRE-CLINICAL SAFETY EVALUATION OF A CELL BASED MEDICINAL PRODUCT (STEM CELL THERAPY). I. Andreini, S. Cinelli, S. Venturella, G. Oberto. RTC – Research Toxicology Centre, Pomezia – Rome, Italy

P106-017DRIED BLOOD SPOT SAMPLE COLLECTION FROM RODENTS FOR GENERATION OF TOXICOKINETIC DATA: OPPORTUNITIES TO REDUCE ANIMAL NUMBERS AND REFINE BLOOD SAMPLING TECHNIQUES. J. Burnett. Covance Laboratories Ltd, Harrogate, United Kingdom

P106-018REFINEMENT OF BLOOD SAMPLING TECHNIQUES FROM THE NON-HUMAN PRIMATE TO PROVIDE DRIED BLOOD SPOT SAMPLES FOR GENERATION OF TOXICOKINETIC DATA. J. Burnett, J. Brook, C. Price, L. Tasker, K. Hanson-Williams. Covance Laboratories Ltd, Harrogate, United Kingdom

P106-019A MODEL TO ASSESS THE SAFETY OF BOTANICALS UTILISING DATA ON HISTORY OF SAFE USE. T. Neely, B. Walsh, P. Russell, A. Van Der Horst, S. O‘hagan. Unilever, Bedfordshire, United Kingdom

P106-020POST-LAUNCH MONITORING OF CHOLESTEROL LOWERING FOOD INGREDIENTS. R. Bradford. Unilever, Bedford, United Kingdom

P106-021EVALUATION FOR HEALTH EFFECTS OF BENZO(A)PYRENE IN FOODS. M. Hwang, J. H. Suh, J. Y. Jung, C. W. Choi, J. H. Moon, H. M. Lee. National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration, Seoul, Korea, Republic of

P106-022CYTOMICS IN THE A-CUTE-TOX PROJECT: CELL-BASED ASSESSMENT OF DRUG SAFETY AND PREDICTION OF HUMAN ACUTE TOXICITY. J. E. O’connor, G. Herrera, D. Laura, A. Martínez-Romero, A. Gomes, S. Pinto. Centro de Investigación Príncipe Felipe, Valencia, Spain

P106-023THE GENOTOXICITY TEST PACKAGE OF PLANT PROTECTION PRODUCTS EVALUATED IN THE EUROPEAN UNION AND THEIR RESPECTIVE EVALUATION IN THE UNITED STATES: OUTCOMES OF THE EVALUATION FOR FUTURE CONSIDERATIONS. P. Papadaki, N. Karabetsou, K. Machera. Benaki Phytopathological Institute, Kifissia, Athens, Greece

P106-024ANTI-OBESITY DRUGS: THE ROLE OF DIETICIANS IN MONITORING SIDE-EFFECTS AND TOXICITY. G. A. Fragkiadakis (1), M. Toutoudaki (2), A. Tsatsakis (2). (1) Technological Education Institute of Crete, Siteia, Greece; (2) University of Crete, Heraklio, Greece

P106-025AFLATOXIN M1 CONTAMINATION IN DIFFERENT TYPES OF MILK: A RISK FOR PUBLIC HEALTH?. R. Ortiz-Martínez, A. Valdivia-Flores, T. Quezada-Tristán, A. Martinez-De Anda, M. C. De Luna-López.. Universidad Autónoma de Aguascalientes, Aguascalientes, Mexico

P106-026ARE OCCUPATIONAL EXPOSURE LIMITS STILL AN EFFECTIVE TOOL FOR CHEMICALS RISK MANAGEMENT AT THE WORK-PLACE? L. Schenk, C. Rudén, S. O. Hansson, M. Wester. Royal Institute of Technology, Stockholm, Sweden


48

P106-027SUBCHRONIC TOXICITY OF ERYTHROPHLEUM SUAVEOLENS PLANT EXTRACTS IN RABBITSW. Abia (1), O. Arojo (2), D. Mingle (3), I. Nmeka (4), A. Atiku (5).(1) Laboratory of Pharmacology and Toxicology, University of Yaounde I; / IHAF Hq Secretariat, BP 31717, Biyem – Assi, Yaounde, Cameroon, Yaounde, Cameroon; (2) Department of Veterinary Medicine, University of Ibadan, Nigeria, Nigeria; (3) Dept’ of Chemical Engineering, University of Cape Coast, Ghana, Ghana; (4) Institute of Medical Laboratory Sciences, National Veterinary Research Institute, Vom, Nigeria, Nigeria; (5) Biochemistry Department, National Veterinary Research Institute, Vom, Nigeria, Nigeria.

P106-028DEVELOPMENTAL NEUROTOXICITY: PRACTICAL EXPERIENCE FROM THE CONDUCT OF A VALIDATION STUDY. E. W. Sommer, C. Senn, R. Gerspach, G. Krinke. Harlan Laboratories Ltd., Itingen, Switzerland

P106-029GENOTOXICITY AND ACUTE TOXICITY OF THE PROCYANIDIN-RICH EXTRACT FROM GRAPE SEEDS. L. Lluis (1), M. Muñoz (1), M. Nogués (1), J. Valls (2), R. Solà (1). (1) Universitat Rovira i Virgili, Reus, Spain; (2) Shirota Functional Foods,

P106-030INTEGRATED INDICATORS FOR HUMAN HEALTH RISK ASSESSMENT IN THE OIL, GAS AND ENERGY INDUSTRY. E. Macedo (1), M. Paoliello (2), M. Barata (1), S. Hacon(1). (1) FIOCRUZ, Rio de Janeiro, Brazil; (2)

P106-031RISK ASSESSMENT OF SYNTHETIC FOOD COLOR EXPOSURE IN THAI POPULATION. W. Benjapong, S. Srianujata, A. Nitithamyong, W. Karnpanit, P. Visetchat, J. Wonglek, R. Peeratikorncharoenkul. Institute of Nutrition, Mahidol university, Bangkok, Thailand

P106-032CEFIC-LRI WORKSHOP ON SKIN SENSITISATION METHODS: WORKSHOP REPORT. J. C. Carrillo (1), D. Eigler (2), P. Kern (3), R. Kreiling (4), M. Woolhiser (5). (1) Shell International, Den Haag, Netherlands; (2) Evonik Goldschmidt GmbH, Essen, Germany, (3) Procter & Gamble Eurocor, Brussels, Belgium; (4) Clariant Produkte (DE) GmbH, Sulzbach, Germany; (5) DOW Chemical Company, MIDLAND, United States.

P106-033REFINEMENT OF THE DERMAL SENSITISATION THRESHOLD FOR SKIN SENSITISATION. B. Safford, N. Gilmour, N. Aptula. SEAC, Sharnbrook, United Kingdom

P106-034PEER-REVIEWING OF HERBAL MEDICINE TOXICITY TEST REPORTS UNDER THE KOREAN NATIONAL TOXICOLOGY PROGRAM. I. J. Yu (1), M. S. Dong (2), J. Y. Lee (1), J. H. Lee (1), M. C. Moon (1), C. S. Kang (1), B. S. Han (1), M. H. Kang (1). (1) Hoseo University, Asan, Korea, Republic of; (2) Korea University, Seoul.

P106-035ETHICAL CONSIDERATIONS OF ACCEPTABILITY OF BIOLOGICAL SAMPLING BY PARTICIPANTS IN A RESEARCH STUDY. N. Noisel, C. Caux, G. Carrier, M. Bouchard. University of Montreal, Montreal, Canada

P106-036REACH REGULATION (EC) 1907/2006: A SURVEY OF COMPANIES SITUATION IN VIEW OF THE FIRST REGISTRATION DEADLINE. R. Butera (1), A. Caldiroli (1), C. Osnaghi (2), A. Sacchi (3), L. Manzo (1). (1) IRCCS Maugeri Foundation and University of Pavia, Pavia, Italy; (2) InterConsortia, Milan and Bruxelles; (3) Sacchi Consulting, Milan and Bruxelles.

P106-037NANOMATERIALS IN REACH. K. Malkiewicz, S. O. Hansson. Royal Institute of Technology (KTH), Stockholm, Sweden

P106-040TUMOUR DATA FROM SPRAGUE-DAWLEY (IGS) RAT DIETARY AND ORAL GAVAGE TUMORIGENICITY STUDIES, COMPLETED OVER THE PERIOD OF 1998 TO 2009. W. Hooks, A. Bottomley, I. Taylor. Huntingdon Life Sciences, Huntingdon, United Kingdom

P106-041WWW.FURETOX.FR : A SEARCH ENGINE OF HUMAN HEALTH TOXICITY VALUES. C. Heyman (1), C. Legout (1), O. Grard (2). (1) Institut De Veille Sanitaire, Lille, France; (2) Ddass, Arras, France.

P106-042JUVENILE STUDIES IN THE MINIPIG: FEASIBILITY STUDY. C. Bouchez, G. Chevalier, R. Forster. CIT, Evreux, France

P106-044INTEGRATING MULTIMEDIA ENVIRONMENTAL MODELS AND EFFECTS MODELS ON A COMMON PLATFORM FOR RISK ASSESSMENT. C. Brochot (1), T. Tanaka (2), E. Johansson (3), R. Beaudouin (1), F. Zeman (1), F. Y. Bois (1), P. Ciffroy (4). (1) Institut National de l‘environnement industriel et des risques (INERIS), Verneuil-en-Halatte, France; (2) Istituto di Chimica Agraria ed Ambientale /Università Cattolica del Sacro Cuore; (3) Facilia; (4) Electricité de France (EDF).

P106-052STRATEGIES FOR THE TOXICOLOGICAL RISK ASSESSMENT OF MULTI RESIDUAL IN CHILEAN MINING INDUSTRIES. L. Börgel, F. Bobadilla, M. Schulthess SERVITOX / Legal Medicine Department, Universidad de Chile, Santiago, Chile

P106-053A 13-WEEK REPEATED DOSE TOXICITY OF EPHEDRA HERBA ADMINISTERED BY ORAL GAVAGE IN F344 RATS. J. I. Huh (1), H. Y. Han (1), S. Rime (1), J. Y. Kim (1), S. J. Park (2), B. S. Min (3), S. J. Kwack (4). (1) Korea Institute of Toxicology, Daejeon, Korea, Republic of; (2) College of Veterinary Medicine, Kyungpook National University; (3) College of Pharmacy, Catholic University of Daegu; (4) National Institute of Toxicological Research.

P106-054IDENTIFYING “NOT CLASSIFIED” SUBSTANCES (ACUTE ORAL LD50 > 2000 MG/KG) USING THE 3T3 NEUTRAL RED UPTAKE CYTOTOXICITY ASSAY: PERFORMANCE IN AN ECVAM EVALUATION. H. Raabe (1), P. Prieto (2), R. Curren (1), M. Whelan (2), A. Hilberer (1), S. Coecke (2), R. Gibson (3), A. Compagnoni (2), T. Hartung (4), A. Kinsner-Ovaskainen (2). (1) Institute for In Vitro Sciences, MD, USA, (2) IHCP/ECVAM, EC-JRC, Ispra, Italy, IHCP, European Commission Joint Research Centre, Ispra, Italy, (3) Health and Safety Laboratory, UK, (4)

Johns Hopkins University, Bloomberg School of Public Health, Baltimore, USA.

BARCELONAIUTOX 2010


49

P107: METABOLISM/ BIOTRANSFORMATION /POLYMORPHISMS

P107-001BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) GENE POLYMORPHISMS: INFLUENCE ON TREATMENT RESPONSE PHENOTYPES OF MAJOR DEPRESSIVE DISORDER. N. A. Kocabas (1), C. Forray (2), S. Kasper (3), S. Linotte (4), I. Massat (5), J. Mendlewicz (4), M. Noro (4), P. Oswald (4), J. Zohar (6), D. Souery (4). (1) FNRS, Free University of Brussels (ULB), Medical School, Lab. Experimental Neurology, Brussels, BE and Gazi University Pharmacy Faculty Department of Toxicology, Ankara, TR, Ankara, Turkey; (2) Translational Research, Lundbeck Research, NJ, USA; (3) Department of General Psychiatry, Medical University of Vienna, Austria; (4) ULB, Brussels, BE; (5) ULB, Lab. Experimental Neurology, Brussels, BE; (6) Chaim Sheba Medical Center Tel-Hashomer, Israel.

P107-002BIODISPOSITION OF CP31398 IN RAT TOXICOLOGY AND EFFICACY STUDIES. I. M. Kapetanovic (1), M. Muzzio (2), D. L. Mccormick (2), A. Mohammed (3), C. V. Rao (3), L. Kopelovich (1). (1) National Cancer Institute, NIH, Bethesda, United States; (2) IIT Research Institute, Chicago, United States; (3) The University of Oklahoma Health Sciences Center, Oklahoma City, United States.

P107-003BIOCHEMICAL TOXICITY OF PHENOL IN TREATED MICE. A. Louei Monfared. School of Veterinary Medicine, University of Ilam, Ilam, Iran., Ilam, Iran (Islamic Republic of)

P107-004TESTOSTERONE HYDROXYLASES IN EVALUATING INDUCTION OF CYTOCHROME P450 ISOENZYMES BY PYRETHROIDS TYPE II DELTAMETHRIN AND CYFLUTHRIN. M. A. Martínez, V. Castellano, E. Ramos, I. Ares, M. Martínez, M. R. Martínez-Larrañaga, A. Anadón.Universidad Complutense de Madrid, Madrid, Spain

P107-005TOXICOKINETICS OF ETHYL TERTIARY BUTYL ETHER METABOLITES IN BLOOD AND TISSUES IN ALDH2 KNOCKOUT AND WILD TYPE MICE. M. Suda, Z. Weng, K. Ohtani, R. S. Wang. National Institute of Occupational Safety and Health, Japan (JNIOSH), Kawasaki, Japan

P107-006URINARY 1-OHP LEVELS IN CHILDREN ARE MODULATED BY CYP1A1*2C, CYP1B1*3, GSTM1*0 AND NQO1*2 POLYMORPHISMS. M. Sánchez-Guerra (1), N. Pelallo-Martínez (2), F. Díaz-Barriga (2), L. Carrizales-Yañez (2), L. Oropeza-Hernández (3), G. Martínez-Aguilar (1), M. Guaderrama-Díaz (1), S. Rothenberg (1), B. Quintanilla-Vega (1). (1) CINVESTAV-IPN, Mexico, Mexico; (2) UASLP, San Luis Potosí, Mexico; (3) PEMEX General Hospital, Nanchtal, Mexico.

P107-007OCTACHLOROSTYRENE INDUCES CYTOCHROME P450, UDP-GLUCURONOSYLTRANSFERASE, AND SULFOTRANSFERASE VIA THE ARYL HYDROCARBON RECEPTOR AND CONSTITUTIVE ANDROSTANE RECEPTOR. Y. Yanagiba. Nagoya University Graduate School of Medicine, Nagoya, Japan

P107-008MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS (MRPS) ARE INVOLVED IN THE DETOXIFICATION OF BENZO[A]PYRENE IN THE INTESTINAL BARRIER. S. Hessel (1), A. John (2), A. Seidel (2), A. Lampen (1). (1) Federal Institute For Risk Assessment, Berlin, Germany, Berlin, Germany; (2) Biochemical Institute for Environmental Carcinogens, Grosshansdorf, Germany,

P107-009ASSOCIATION OF CYP2E1 GENE POLYMORPHISMS WITH ATHEROSCLEROSIS: A PRELIMINARY STUDY. L. Şahiner (1), Z. Kayaaltı (2), T. Soylemezoglu (2). (1) Ankara Oncology Hospital, Ankara, TURKEY, Ankara, Turkey; (2) Ankara University Institute of Forensic Medicine,

P107-010EFFECT OF COLCHICINE ON P-GLYCOPROTEIN EXPRESSION AND ACTIVITY IN CACO2 CELLS. T. Houdkova (1), R. Silva (1), A. Cordeiro-Da-Silva (2), H. Carmo (1), F. Remião (1). (1) Faculty of Pharmacy, University of Porto, Porto, Portugal; (2) IBMC – Institute of Molecular and Cellular Biology, University of Porto.

P107-011IN VITRO METABOLISM OF M1 VINCLOZOLIN METABOLITE BY RAT LIVER MICROSOMES. A. Sierra-Santoyo, M. D. L. Lopez-Gonzalez, F. G. García-Montes De Oca. Departamento de Toxicologia, Cinvestav-IPN, Mexico, Mexico

P107-012INFLUENCE OF AGING AND PROSTATIC DISEASE IN THE EXPRESSION AND ACTIVITY OF P-GLYCOPROTEIN IN HUMAN LYMPHOCYTES. V. Vilas_boas (1), A. M. Martins (1), R. Silva (1), S. A. Lima (2), R. Medeiros (3), A. Cordeiro-Da-Silva (2), F. Remião (1). (1) REQUIMTE, Porto, Portugal; (2) IBMC, Portugal; (3) Molecular Oncology Unit, Portugal.

P107-013CHARACTERIZATION OF HUMAN ARYL HYDROCARBON RECEPTOR POLYMORPHISMS IN MCF-7 BREAST CANCER CELLS. T. Celius (1), C. Rowlands (2), J. Matthews (1). (1) University of Toronto, Toronto, Canada; (2) Dow Chemical Company.

P107-014THE PARAQUAT-INDUCED TOXICITY IS REVERSED WITH THE CO-EXPOSURE TO DOXORUBICIN IN CACO-2 CELLS. R. Silva (1), H. Carmo (1), P. Guedes De Pinho (1), R. Dinis-Oliveira (2), F. Carvalho (1), M. De Lourdes Bastos (1), F. Remião (1). (1) REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal; (2) REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto; Faculty of Medicine, University of Porto;Department of Clinical Analysis and Public Health,Center of Research in Health Technologies (CITS)-IPSN-CESPU,CRL,Vila Nova de Famalicão.

P107-015PROTEIN ADDUCT FORMATION: A POSSIBLE FACTOR IN HYPERSENSITIVITY REACTIONS INDUCED BY THE ANTI HIV DRUG ABACAVIR. M. M. Marques, C. Charneira, A. M. Antunes. Instituto Superior Técnico, Lisboa, Portugal

P107-016ANALYSES OF XENOBIOTIC METABOLIZING ENZYME ACTIVITIES IN HUMAN RECONSTRUCTED SKIN EQUIVALENTS. C. Jäckh. BASF SE, Frankenthal, Germany

P107-017EDIBLE RASPBERRY COMPOSITION POWDER CONTAINING HIGH LEVELS OF ELAGIC ACID REDUCED NICOTINE - INDUCED PLACE PREFERENCE IN MICE. R. Pérez-Pastén (1), A. Atitlán-Gil (2), F. Santiago-Kerstupp (2), C. Zuñiga-Pérez (2), G. Chamorro-Cevallos (1). (1) Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico, D.F., Mexico; (2) Instituto de Ciencias de la Salud y Centro de Investigaciones Químicas - UAEH, Pachuca, Mexico.

P107-018CHEMOPREVENTIVE EFFECTS OF PHLORETIN AND SULFORAPHANE AGAINST AFB1-8, 9-EPOXIDE IN AML 12 CELLS. B. R. Kim, B. M. Choi, S. S. Gao. WonkWang University School of Medicine, Iksan-City, Korea, Republic of


50

P107-019MODULATION OF CYTOCHROME P450 1B1 BY TETRAMETHOXYSTILBENE. Y. J. Chun (1), Y. K. Oh (1), D. Kim (2), M. Y. Kim (1). (1) College of Pharmacy Chung-Ang University, Seoul, Korea, Republic of; (2) Department of Biological Sciences, Konkuk University, Seoul, Korea, Republic of.

P107-020GENOTYPE AND ALLELE FREQUENCIES OF POLYMORPHIC ADH AND ALDH IN THE TURKISH POPULATION. B. Alpertunga, E. S. Yildiz. Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Istanbul, Turkey

P107-021CYCLOOXYGENASE-2 POLYMORPHISMS AND PANCREATIC CANCER SUSCEPTIBILITY. G. Özhan (1), R. Lochan (2), J. B. Leathart (3), R. Charnley (2), A. K. Daly (3). (1) Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Istanbul, Turkey, Istanbul, Turkey; (2) Newcastle University, Freeman Hospital, Department of Surgery, Hepato-Pancreato-Biliary Unit, Newcastle upon Tyne, United Kingdom, Newcastle upon Tyne, United Kingdom; (3) Newcastle University, Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom, Newcastle upon Tyne, United Kingdom.

P107-022EFFECT OF ENVIRONMENTAL CHEMICALS ON CYTOCHROME P450 ACTIVITIES OF FETAL AND NEONATAL RATS. K. Sugihara (1), M. Arai (2), H. Sako (2), S. Kitamura (3), S. Ohta (2). (1) Hiroshima International University, Kure, Japan; (2) Hiroshima University, Japan; (3) Nihon Pharmaceutical University.

P107-023EFFECT OF CHROMIUM PICOLINATE ON THE TISSULAR ZN/CU RATIO OF DIABETIC GROWING RATS. M. V. Aguilar, J. M. Laborda, A. Bernao, M. C. Martinez Para, I. Meseguer, C. J. Mateos, M. J. González Muñoz. Facultad de Farmacia, Alcalá de Henares, Spain

P107-024PORCINE CYP3A EXPRESSION IN LIVERS FROM FOETUSES AND NEONATAL GÖTTINGEN MINIPIGS. M. T. Skaanild, M. L. H. Hermann. University of Copenhagen, Frederiksberg C, Denmark

P107-025REACTIVITY OF ANTITUMOR ACYLFULVENES WITH SELENOCYSTEINE-CONTAINING REDOX-REGULATING ENZYMES IN CANCER CELLS. K. E. Pietsch (1), X. Liu (2), S. J. Sturla (1). (1) ETH Zürich, Zürich, Switzerland; (2) University of Minnesota,

P107-026CALIBRATION OF PBPK MODELS BASED ON IN VIVO AND IN VITRO DATA TO DESCRIBE COMPLEX BIOTRANSFORMATION PROCESSES. D. Habka (1), A. R. Péry (1), C. Aninat (2), A. Corlu (2), C. Guguen-Guillouzo (2), E. Leclerc (3), C. Legallais (3), C. Brochot (1). (1) Institut National de l’Environnement Industriel et des Risques - INERIS, Unité METO, Verneuil En Halatte, France; (2) Université Rennes 1, INSERM - U991, IFR 140, Rennes, France; (3) Université de Technologie de Compiègne, CNRS - UMR6600, Compiègne, France.

P107-027HEPATIC AND RENAL XANTHINE OXIDOREDUCTASE ACTIVITY IN OBESE ZUCKER RAT MODEL OF METABOLIC SYNDROME. J. Laakso (1), R. Lapatto (2), T. Vaskonen (3). (1) Finnish Food Safety Authority, Evira, Helsinki, Finland; (2) Hospital for Children and Adolescents, Helsinki, Finland; (3) Institute of Biomedicine, Pharmacology.

P107-032EFFECT OF TREATMENT PERIOD WITH CHROMIUM PICOLINATE ON THE TISSULAR ZN/CU RATIO OF DIABETIC RATS. M. V. Aguilar, J. M. Laborda, M. J. González, A. Bernao, I. Meseguer, M. C. Martínez Para, C. J. Mateos. Alcalá de Henares University, Alcalá de Henares, Spain

P108: ECOTOXICOLOGY

P108-001EXCESSIVE DANGER OF ORGANOPHOSPHORUS PESTICIDES FOR AQUATIC ECOSYSTEM HEALTH. V. Tonkopii. Institute of Limnology.Rus.Acad.Sci., St.Petersburg, Russian Federation

P108-002IMPACT OF HUMAN ACTIVITIES ON ALUMINUM CONTAMINATION IN THE DRAINAGE CANALS IN THE NILE DELTA, EGYPT. A. E. Alnenaei, M. Authman. Faculty of Science, Menufiya University, Shebeen Alkom, Egypt

P108-003THE USE OF ROE DEER AS BIOINDICATOR FOR ENVIRONMENTAL ASSESSMENT: EFFECT OF SEX ON EROD AND GST ENZYMATIC ACTIVITY. I. De La Casa Resino

(1), M. P. Míguez Santillán (1), D. Hernández Moreno (1), A. López Beceiro (2), L. E. Fidalgo Álvarez (2), L. Rigueira Rey (2), M. Pérez-López (1). (1) Faculty of Veterinary Medicine. University of Extremadura, Caceres, Spain; (2) Fac of Veterinary Medicine. University of Santiago de Compostela, Lugo, Spain.

P108-004EFFECTS OF SEMI-STATIC EXPOSITION TO CARBOFURAN ON XENOBIOTIC METABOLIZING ACTIVITIES IN COMMON CARP (CYPRINUS CARPIO). C. Ensibi (1), D. Hernández Moreno (2), F. Soler Rodríguez (2), M. N. Daly Yahya (1), M. Pérez-López (2). (1) University of 7 November Carthage, Zarzouna, Tunisia; (2) University of Extremadura, Caceres, Spain

P108-005SELECTIVE CHROMIUM RESISTANCE OBTAINED BY SELECTED DICTYOSPHAERIUM CHLORELLOIDES STRAINS ACCORDING TO ITS OXIDATION STATE. M. C. Bartolomé Camacho (1), A. D’ors (2), M. Pereira (2), J. M. Jimenez (2), S. Sanchez-Fortún (2). (1) Universidad Michoacana De San Nicolas Hidalgo, Morelia, Mexico; (2) Universidad Complutense, Madrid,, Spain.

P108-006EFFECTS OF PERFLUOROOCTANOIC ACID AND PERFLUOROOCTANE SULFONATE ON GENE EXPRESSION PROFILES IN MEDAKA (ORYZIAS LATIPES). W. Lee (1), Y. Kagami (2). (1) Chang Jung Christian University, Tainan, Taiwan; (2) Ecogenomics, Inc., Japan.

P108-007POSSIBILITY OF PERSTERIL USING AS EFFECTIVE ANTIMYCOTIC AGENT IN FISHERIES: PRELIMINARY STUDY. J. Machova (1), T. Meinelt (2), J. Velisek (1), V. Stejskal (1), E. Sudova (1). (1) University of South Bohemia České Budějovice Faculty of Fisheries and Protection of, Vodnany, Czech Republic; (2) , Germany.

P108-008ORGANOCHLORINE RESIDUES IN EGGS OF SLENDER-BILLED GULL (LARUS GENEI) FROM THE SOUTH-EASTERN SPAIN. P. Toledo-Monsonís (1), E. Martínez-López

(1), P. María-Mojica (2), A. J. García-Fernández (1). (1) University of Murcia, Murcia, Spain; (2) Generalitat Valenciana, Alicante, Spain.

BARCELONAIUTOX 2010


51

P108-009RESPONSES OF MULTIPLE BIOMARKERS IN JUVENILE RAINBOW TROUT, ONCORHYNCHUS MYKISS, AFTER ACUTE EXPOSURE TO A HUMAN PHARMACEUTICAL CARPAMAZEPINE. Z. H. Li (1), V. Zlabek (1), J. Velisek (1), R. Grabic (2), J. Machova (1), J. Kolarova (1), T. Randak (1). (1) University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, Research Institute of Fish Culture and Hydrobiology, Vodnany, Czech Republic; (2) Department of Chemistry, Umea University, SE-90187 Umea, Sweden.

P108-010THE LIGAND BINDING DOMAIN - THE KEY TO THE CLASSIFICATION OF AVIAN SENSITIVITY TO DIOXIN-LIKE COMPOUNDS. R. Farmahin (1), D. Wu (2), S. J. Bursian (3), D. Crump (2), J. P. Giesy (4), M. E. Hahn (5), S. P. Jones (2), S. I. Karchner (5), L. J. Mundy (2), M. J. Zwiernik (3), S. W. Kennedy (2). (1) Department of Biology, University of Ottawa, Ottawa, Canada; (2) Environment Canada, National Wildlife Research Centre, Ottawa, Canada; (3) Michigan State University; (4) University of Saskatchewan; (5) Department of Biology, Woods Hole Oceanographic Institution.

P108-011CONTEMPORARY EVOLUTION OF FENVALERATE RESISTANCE IN NON-TARGET BLACKFLIES (DIPTERA: SIMULIIDAE) FROM ARGENTINA. C. Montagna, L. Anguiano, A. Pechen De D’ Angelo. Universidad Nacional del Comahue, Neuquén, Argentina

P108-012EFFECT OF FLUORANTHENE ON PEA PLANT (PISUM SATIVUM L.) ANATOMICAL-MORPHOLOGICAL STUDY. M. Beklova (1), I. Soukupova (1), P. Babula (1), M. Kummerova

(2), L. Havel (3), R. Kizek (3). (1) University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic; (2) Masaryk University, Brno, Czech Republic; (3) Mendel University in Brno, Brno, Czech Republic.

P108-013EFFECTS OF ETHINYLESTRADIOL ON DNA METHYLATION IN A 5-PRIME FLANKING REGION OF THE VITELLOGENIN I GENE IN ADULT ZEBRAFISH (DANIO RERIO). M. Hjalmarsson (1), N. Tooke (2), B. Brunström (1). (1) Uppsala University, Department of Environmental Toxicology, Uppsala, Sweden; (2) QIAGEN AB.

P108-014LETHAL AND SUBLETHAL EFFECTS OF METHYLMERCURY TO ZEBRAFISH EMBRYOS. J. P. Garcia Cambero, A. Castaño Calvo. Instituto De Salud Carlos III, Madrid, Spain

P108-015GLOBAL TRANSCRIPTOME ANALYSIS OF RICE ROOTS IN RESPONSE TO ARSENIC STRESS. T. L. Huang (1), W. C. Chi (1), C. C. Chen (1), Y. A. Chen (2), H. J. Huang (1). (1) National Cheng Kung University, TAINAN, Taiwan; (2) National Sun Yat-sen University, Kaohsiung, Taiwan.

P108-016TOXICOLOGICAL TRANSCRIPTONE CHANGES AND ANTIOXIDANT MODULATION OF RICE SEEDLINGS IN EARLY RESPONSE TO MERCURY. Y. A. Chen (1), T. L. Huang (2), S. F. Fu (2), H. J. Huang (2). (1) National Sun Yat-sen University; National Cheng Kung University, Kaohsiung, Taiwan; (2) National Cheng Kung University, Tainan, Taiwan.

P108-017HAEMOSTATIC PARAMETERS IN FALLOW DEER (DAMA DAMA) AND THEIR IMPORTANCE IN THE DIAGNOSTICS OF DISEASES AND ANTICOAGULANT RODENTICIDES’ POISONING. Z. Široká, I. Soukupová, J. Pikula, B. Kročilová, J. Sedláčková, H. Banďouchová, F. Vitula. University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic

P108-018ECOTOXICOLOGICAL TEST METHODS IN THE LCA OF BIO-BASED LUBRICANTS. J. Bressling, W. Dott. Institute of Hygiene and Environmental Medicine, RWTH Aachen University, Aachen, Germany

P108-019ROLE OF METALLOTHIONEIN POLYMORPHISM ON ACCUMULATION OF CADMIUM IN HUMAN PLACENTA. D. Tekin (1), Z. Kayaaltı (1), G. Mergen (1), G. Kurtay (2), T. Söylemezoğlu (1). (1) Institute of Forensic Medicine, Ankara, Turkey; (2) Faculty of Medicine.

P108-020GENE EXPRESSION PROFILING IN THE MODEL YEAST SACCHAROMYCES CEREVISIAE TO IDENTIFY MOLECULAR BIOMARKERS RELEVANT FOR ASSESSMENT OF PESTICIDE TOXICITY. F. N. Gil (1), A. Gonçalves (1), J. D. Becker (2), C. A. Viegas (1). (1) IBB-Institute for Biotechnology and Bioengineering, CEBQ, Instituto Superior Técnico, Lisboa, Portugal; (2) Instituto Gulbenkian de Ciência, Fundação Calouste Gulbenkian, Oeiras, Portugal.

P108-021DILUTION AND ULTRAFILTRATION OF THE BRAIN HOMOGENATE AS AN EFFECTIVE TOOL IN THE DIAGNOSIS OF CARBAMATE POISONING. F. Soler-Rodriguez, M. E. Gallego-Rodríguez, M. Pérez-López, D. Hernández-Moreno. Facultad de Veterinaria (UEX), Cáceres, Spain

P108-022USE OF ARTEMIA SALINA TO IDENTIFY SITES WITH RISK OF CONTAMINATION IN THE WATERS OF BABITONGA BAY. C. Vaz, T. M. N. D. Oliveira, R. F. S. Böhm, E. C. Spitzner, M. Simm, V. G. Barros. Universidade da Região de Joinville - Univille, Joinville, Brazil

P108-023WATER QUALITY ASSESSMENT USING A REPRODUCTION TOXICITY TEST WITH MYSIDOPSIS JUNIAE AS A BIOINDICATOR. T. M. N. Oliveira (1), C. Vaz (1), W. G. Matias

(2), R. F. S. Böhm (1), E. C. Spitzner (1), M. Simm (1), V. G. Barros (1). (1) Universidade da Região de Joinville - Univille, Joinville, Brazil; (2) Universidade Federal de Santa Catarina – UFSC.

P108-024EFFECT OF TEMPERATURE AND SALINITY IN MYSIDOPSIS JUNIAE REPRODUCTION. T. M. N. Oliveira (1), C. Vaz (1), T. Kleine (1), R. F. S. Böhm (1), W. G. Matias (2). (1)

Universidade da Região de Joinville - Univille, Joinville, Brazil; (2) Universidade Federal de Santa Catarina – UFSC.

P108-025METHOD DEFINITION AND APPLICATION OF A PILOT ASSAY FOR A LIFE-CYCLE TOXICITY TEST UNDER SEMI-STATIC CONDITIONS FOR THE MARINE ORGANISM MYSIDOPSIS JUNIAE. C. Vaz (1), W. G. Matias (2), T. M. N. Oliveira (1), R. F. S. Böhm (1), E. C. Spitzner (1), M. Simm (1), V. G. Barros (1). (1) Universidade da Região de Joinville - Univille, Joinville, Brazil; (2) Universidade Federal de Santa Catarina – UFSC.

P108-026ECOTOXICOLOGICAL EVALUATION OF SOIL CONTAMINATED WITH HYDROCARBONS FOLLOWING A PROCESS OF REMEDIATION WITH COMPOST FROM SEWAGE. G. Díaz López (1), M. Arrizabalaga (2), S. Izquieta (2), Í. Virto (3), A. Castaño (1). (1) Centro Nacional De Sanidad Ambiental. Instituto De Salud Carlos Iii., Majadahonda, Spain; (2)

Namainsa, Navarra, Multiva Baja, Spain; (3) Universidad Pública De Navarra, Pamplona, Spain.

P108-027BIOACTIVITY OF SYNERGIZED NEEM (AZADIRACHTA INDICA) AND POTENTATED INSECTICIDES ON BUFFO REGULARIS AS A NONTARGET ORGANISM. I. Ahmed

(1), S. Siddig (2). (1) Khartoum College of Medical sciences, Khartoum, Sudan; (2) University of Khartoum, Khartoum, Sudan.


52

P108-028OXIDATIVE STRESS-MEDIATED CYTOTOXICITY OF CADMIUM IN CHICKEN SPLENIC LYMPHOCYTES. J. L. Li (1), S. Li (1), Z. X. Tang (2), S. W. Xu (1). (1) College of Veterinary Medicine, Northeast Agricultural University, Harbin, China; (2) College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.

P108-029EARLY WARNING DETECTION OF HEXAVALENT CHROMIUM IN WATER BY “DAPHNIA TOXIMETER”. F. Di Giacinto (1), S. Girotti (2), M. Berti (1), S. A. Angioni (1), N. Ferri (1). (1) Istituto Zooprofilattico Sperimentale dell‘Abruzzo e del Molise „G.Caporale“, Teramo, Italy; (2) University of Bologna.

P108-030BILASTINE: ENVIRONMENTAL RISK ASSESSMENT. F. Ledo (1), M. L. Lucero (1), B. Seyfred (2), M. Weissenfeld (2), W. Megel (2), A. Peither (2), P. Roulstone (2), T. Schoop (2), E. Kiefer (2). (1) FAES FARMA S.A., Leioa, Spain; (2) Harlan Laboratories Ltd., Itingen, Switzerland.

P108-031BIOCHEMICAL BIOMARKERS IN OREOCHROMIS NILOTICUS EXPOSED TO MIXTURES OF BENZO[A]PYRENE AND DIAZINON. E. Alves De Almeida, C. P. Trídico, D. C. Da Silva, L. Nogueira, A. C. Ferreira Rodrigues. IBILCE - UNESP, São José do Rio Preto, Brazil

P108-032EVALUATION OF BIOCHEMICAL BIOMARKERS IN NILE TILAPIA EXPOSED TO METALS AND BENZO[A]PYRENE. L. R. Maschio, D. Caetano Da Silva, E. Alves De Almeida. UNESP - São Paulo State University, IBILCE, Sao Jose do Rio Preto, Brazil

P108-033EVALUATION FOR ECO-TOXICITY RISK OF ACCIDENT POLLUTANT IN TYPICAL RIVER. L. Zhengtao. Chinese Research Academy of Environmental Sciences, Beijing, China

P108-034VERIFICATION OF MICROBIOTEST APPLICATION FOR ASSESSING TOXIC IMPACT OF CHEMICALS IN DUCKWEED (LEMNA MINOR). I. Soukupova, M. Beklova. University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic

P108-035TOXICITY OF 66 SUBSTITUTED ANILINES AND PHENOLS TO BACTERIA ALIIVIBRIO FISCHERI AND ALGAE PSEUDOKIRCHNERIELLA SUBCAPITATA: EFFECT OF CHEMICAL STRUCTURE. V. Aruoja, M. Sihtmäe, A. Kahru, H. C. Dubourguier. National Institute of Chemical Physics and Biophysics, Tallinn, Estonia

P108-036EFFECT OF DIAZINON EXPOSURE ON BLOOD PORHYRIN LEVELS IN RABBITS. M. Perez-Lopez, M. P. Miguez, M. Gil Hernandez, F. Soler, D. Hernandez-Moreno. Fac of Veterinary Medicine, Caceres, Spain

P108-037INTERFERENCE OF SOME ENVIRONMENTAL CONTAMINANTS WITH RETINOID SIGNALING IN VITRO. M. Benisek, M. Richterova, P. Kubincova, K. Hilscherova. RECETOX, Masaryk University, Brno, Czech Republic

P108-038BIOLOGY-BASED DYNAMIC APPROACH FOR THE RECONCILIATION OF ACUTE AND CHRONIC TOXICITY TESTS: APPLICATION TO DAPHNIA MAGNA. J. M. Zaldivar Comenges (1), J. Baraibar Fentanes (1), A. Worth (2). (1) European Commission, Ispra, Italy; (2) European Commission – Joint Research Centre, Ispra,. EUR.

P108-039EFFECTS ASSESSMENT OF OXYTETRACYCLINE IN THE AQUATIC PLANT LEMNA MINOR. J. Pro (1), M. R. Martínez-Larrañaga (2), A. Anadón (2). (1) Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), MADRID, Spain; (2) Universidad Complutense de Madrid, Madrid, Spain.

P108-040INFLUENCE OF MG, CR, FE AND ZN FROM FOOD SUPPLEMENTS ON SELECTED TYPES OF AQUATIC ORGANISMS. J. Bošnir (1), D. Puntarić (1), Ž. Cvetković (1), L. Barušić

(1), L. Pollak (2). (1) Public Health Institute “dr Andrija Štampar”, Zagreb, Croatia (Hrvatska); (2) , Zagreb, Croatia (Hrvatska).

P108-041ECOTOXICOLOGICAL STUDIES RELATED TO PESTICIDE USE IN THE EBRO RIVER DELTA. M. C. Riva (1), B. Vallès (2), V. Ochoa (2), A. Roque (2). (1) CRIT (Center for Research and Innovation in Toxicology) Technical University of Catalonia (UPC), TERRASSA, Spain; (2) Technical University of Catalonia (UPC), TERRASSA, Spain.

P108-042EVALUATION OF TOXICOLOGICAL ASPECTS OF TREATED WASTEWATER SAMPLES. L. Camps (1), J. De Lapuente (1), J. González-Linares (1), J. Serret (1), M. Solà (1), R. Céspedes-Sánchez (2), L. Matía (3), M. Borràs (1). (1) Parc Científic de Barcelona, Barcelona, Spain; (2) Aguas de Barcelona & CETaqua (Water Technology Center); (3) Aguas de Barcelona.

P108-043EFFECT OF A WASTE INCINERATOR ON HEMATOLOGY VALUES IN TWO SPECIES OF WILD RODENTS IN NORTHWESTERN SPAIN. M. T. Gómez Mora, J. De Lapuente, J. Serret Salse, M. Borras Suarez. Parc Cientific de Barcelona, Sevilla, Spain

P108-044EFFECTS OF LEAD ON BONE BIOMINERALIZATION IN FREE-LIVING WILD BOAR (SUS SCROFA) FROM A POLLUTED MINING AREA. J. Rodríguez-Estival (1), P. Álvarez-Lloret (2), L. Monsalve-González (1), A. Rodríguez-Navarro (2), R. Mateo (1). (1) Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC-UCLM-JCCM), Ciudad Real, Spain; (2)

Universidad de Granada, Facultad de Ciencias, Granada, Spain.

P108-045ACUTE EFFECTS OF PYRENE ON THE COMMON GOBY POMATOSCHISTUS MICROPS (TELEOSTEI, GOBIIDAE). M. Oliveira (1), L. R. Vieira (1), C. Gravato (1), L. Guilhermino (2). (1) CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidade do Porto, Portugal, Porto, Portugal; (2) CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidade do Porto, Laboratório de Ecotoxicologia; ICBAS - Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Departamento de Estudos de Populações, Laboratório.

P108-046EFFECTS OF PB EXPOSURE ON OXIDATIVE STRESS BIOMARKERS AND PLASMA BIOCHEMISTRY IN WATERBIRDS FROM MEDINA LAGOON (SOUTHERN SPAIN)M. Martínez Haro (1), A. J. Green (2), J. Rodríguez-Estival (3), P. Camarero (3), R. Mateo (3). (1) Instituto de Investigación en Recursos Cinegéticos/Estación Biológica de Doñana, Ciudad Real, Spain; (2) Estación Biológica de Doñana; (3) Instituto de Investigación en Recursos Cinegéticos,

BARCELONAIUTOX 2010


53

P108-047GLUTATHIONE S-TRANSFERASE ACTIVITY, GLUTATHIONE AND LIPID PEROXIDATION LEVELS IN MALLARD (ANAS PLATYRHYNCHOS) ERYTHROCYTES EXPOSED TO LEAD AND CADMIUM IN VITRO. A. Hernández García (1), D. Romero (1), C. A. Tagliati (2), C. Gravato (3), L. Guilhermino (3), A. J. García Fernández (1). (1) University of Murcia, Area of Toxicology, Murcia, Spain; (2) Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; (3) CIMAR-LA/CIIMAR & ICBAS, Universidade do Porto, Portugal.

P108-048EFFECTS ON ENZYMATIC ANTIOXIDANT SYSTEM OF MALLARD (ANAS PLATYRHYNCHOS) ERYTHROCYTES EXPOSED IN VITRO TO LEAD AND CADMIUM. A. Hernández-García (1), D. Romero (1), C. Gravato (2), L. Guilhermino (2), A. J. García-Fernández (1). (1) University of Mucia, Area of Toxicology, Murcia, Spain; (2) CIMAR-LA/CIIMAR & ICBAS, Universidade do Porto., Porto, Portugal.

P108-049CHARACTERIZATION OF HEPATIC OXIDATIVE STRESS PARAMETERS IN THE RED FOX (VULPES VULPES). M. P. Míguez, I. Laguna, A. López-Beceiro, L. E. Fidalgo, D. Hernández-Moreno, A. Ramos, M. Pérez-López. Veterinary Faculty, Cáceres, Spain

P108-050ORGANOCHLORINE PESTICIDES LEVELS IN EAGLE OWL (BUBO BUBO) EGGS: TEMPORAL TRENDS AND SUBLETHAL EFFECTS. P. Gómez-Ramírez (1), E. Martínez-López (1), P. Maria-Mojica (1), S. Espin (1), A. Zweers (2), A. García-Fernández (1), N. Van Den Brink (2). (1) University of Murcia, Murcia, Spain; (2) Alterra, Wageningen Institute for Environment and Climate Research (WIMEK), Wageningen UR, Wageningen, Netherlands.

P108-051HIGH SENSITIVITY OF MUSCLE BUTYRYLCHOLINESTERASE OF THE GILTHEAD SEABREAM (SPARUS AURATA) TO VARIOUS ORGANOPHOSPHATE COMPOUNDS. G. Albendín, J. M. Arellano, M. P. Mánuel-Vez, M. I. Arufe.Faculty of Marine and Environmental Sciences, Puerto Real, Spain

P108-052MONITORING OF INDUSTRIAL AND AGRICULTURAL POLLUTION BY ANTIOXIDANT ENZYME ACTIVITIES AND PROTEIN OXIDATION IN CARP ALONG THE RIVER BUYUK MENDERES: PRELIMINARY IMPLICATIONS. H. Orhan (1), R. Kocagoz (1), M. Karaca (1), F. Percin (2), O. Ozaydin (2). (1) Ege University, Izmir, Turkey; (2) Ege University, Faculty of Pharmacy, Department of Toxicology, 35100 Izmir, Turkey.

P108-053TOXICOGENOMICS TO GROUP ENVIRONMENTAL CHEMICALS? A. Hawliczek, H. Segner. University of Bern, Institute for Animal Pathology, Bern, Switzerland

P108-058PRELIMINARY RESULTS ON HEAVY METALS CONTENT OF SPONTANEOUS HERBS GROWN IN POLLUTED AND UNCONTAMINATED SITES. M. G. Volpe (1), M. Nazzaro (1), A. De Mattia (2), F. Volpe (2), M. Di Stasio (1), R. Scudiero (3), F. La Cara (4). (1) Istituto di Scienze dell’Alimentazione, Avellino, Italy; (2) Agenzia Regionale Protezione Ambientale Campania, Italy; (3) Dipartimento di Scienze Biologiche, Università degli Studi di Napoli Federico II; (4) Istituto di Biochimica delle Proteine,

P108-063METALLOTHIONIN EXPRESSION AS A BIOMARKER OF HEAVY METAL POLLUTION AT JEDDAH COAST-KSA. M. Montaser, M. Mahfuz, S. El-Shazly, G. Ibraheim, S. Bakry. Biotechnology Department, Faculty of Science, Taif University, 888 Hawia,Taif, KSA, Taif, Saudi Arabia

P108-065DNA DAMAGE ON CROCODYLUS MORELETTI FROM AN URBAN LAKE, EXPOSURE TO METALS AT SOUTHERN GULF OF MEXICO. M. T. G. Rodríguez (1), R. G. Aldeco (1), L. S. Osorio (2). (1) Universidad Juárez Autónoma de Tabasco, Villahermosa, Mexico; (2) Universidad Nacional Autónoma de México, México, Mexico

P201: IN VITRO TESTING METHODS

P201-001PREDICTION OF SKIN SENSITIZERS BY COMBINING A HIGH-THROUGHPUT KERATINOCYTE-BASED REPORTER GENE ASSAY WITH PEPTIDE REACTIVITY MEASUREMENTS. G. Ellis, A. Natsch, R. Emter. Banaras Hindu University, Bilaspur, India

P201-002AN INDIGENOUSLY DEVELOPED HUMAN WHOLE BLOOD ASSAY FOR PYROGENICITY: A COMPARATIVE ASSESSMENT. P. Mohanan, B. Siddharth, C. Geetha. Sree Chitra Tirunal Institute For Medical Sciences And Technology, BMT Wing, Thiruvananthapuram, Kerala, India

P201-003PH DEPENDENCE ON THE HEMOLYSIS INDUCED BY ANIONIC SURFACTANTS. D. Rubert, M. Mitjans, M. P. Vinardell. Universitat de Barcelona, Barcelona, Spain

P201-004ANTIOXIDANT AND ANTICANCER ACTIVITY OF ESSENTIAL OIL FROM ORIGANUM ONITES (LAMIACEAE). A. Ozkan, A. Erdogan, N. G. Trak. Akdeniz University, Antalya, Turkey

P201-005QUICK CELLULAR TOXICITY TESTING. A. Eskov, R. Kaumov, A. Sokolov. Firm „BMK-INVEST“, ZAO, Moscow, Russian Federation

P201-006THE VALIDATION OF A NEW RECONSTRUCTED HUMAN SKIN EQUIVALENT MODEL, KERASKIN FOR THE ALTERNATIVE TEST METHODS FOR THE SKIN IRRITATION. B. H. Kim. Dept of Public Health, Daegu, Korea, Republic of

P201-007ORGAN CROSS-TALK IN A MULTI COMPARTMENT CONNECTED CULTURE BIOREACTOR. A. Ahluwalia (1), F. Vozzi (2), M. Guzzardi (1), C. Domenici (2), D. Mazzei (1). (1) Centro Interdepartimentale di Ricerca, “E. Piaggio”, Pisa, Italy; (2) , Pisa, Italy.

P201-008ISOCYP-TOX: A NEW READY-TO-USE CONCEPT FOR IN VITRO EVALUATION OF BIOTRANSFORMATION-MEDIATED TOXICITY. M. Vilà, J. M. Miquel, G. Quintàs, M. Fabre. ADVANCELL, Advanced In Vitro Cell Technologies, S.A., Barcelona, Spain

P201-009CYTOTOXICITY TESTING WITH ANOXIC K-562. Y. Li (1), P. Heroux (1), I. Kyrychenko (2). (1) McGill University, Montreal, Canada; (2) Cell Culture Technologies, Kitchener, Canada.


54

P201-010PREDICTION OF CARCINOGENIC AND GENOTOXIC PROPERTIES OF CHEMICALS USING GENE EXPRESSION PROFILES FROM A HUMAN HEPATIC CELL LINE. C. Magkoufopoulou, D. Jennen, S. Claessen, J. Kleinjans, J. Van Delft. Health Risk Analysis and Toxicology, Netherlands Toxicogenomics Center, Maastricht, Netherlands

P201-011PREDICTING CYTOTOXIC RESPONSE TO DRUGS: THE MULTI-COMPARTMENTAL BIOREACTOR SYSTEM. F. Vozzi (1), F. Montemurro (2), M. A. Guzzardi (1), C. Domenici (1), A. Ahluwalia (2). (1) IFC-CNR, pisa, Italy; (2) Interdepartmental Research Centre “E.Piaggio”.

P201-012VALIDATION OF THE IN VITRO COMET ASSAY IN CONJUNCTION WITH AN AIR-LIQUID INTERFACE EXPOSURE OF CIGARETTE SMOKE IN HUMAN LUNG EPITHELIAL CELLS. S. Weber, M. Hebestreit, T. Wilms, B. Kurkowsky. PHILIP MORRIS Research Laboratories GmbH, Cologne, Germany

P201-013EFFECT OF PROBIOTIC ESCHERICHIA COLI NISSLE COMPONENTS ON THE CACO-2 CELL MONOLAYER INTEGRITY. V. Stetinova (1), L. Smetanova (2), J. Kvetina (2), H. Tlaskalova-Hogenova (3). (1) Institute of Experimental Biopharmaceutics, Joint Research Centre of the Academy of Sciences of the Czech Republic and PRO.MED.CS Praha a.s., Hradec Kralove, Czech Republic; (2) Institute of Experimental Biopharmaceutics, Joint Research Centre of the Academy of Sciences of the Czech republic and PRO.MED.CS Praha a.s; (3) Institute of Microbiology, Academy of Sciences of the Czech Republic.

P201-014EFFECT OF BONE MORPHOGENETIC (BMP-2) ON THE AGED HUMAN ARTICULAR CHONDROCYTES. M. Taheri Moghadam, M. Hashemitabar, M. Orazizadeh. Medical School , Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran (Islamic Republic of)

P201-015AN EXPOSURE SYSTEM FOR IN VITRO CELL CULTURE INVESTIGATIONS OF CIGARETTE SMOKE TOXICITY AT THE AIR-LIQUID INTERFACE. J. Adamson, D. Azzopardi, M. Gaça. British American Tobacco, Southampton, United Kingdom

P201-016HUMAN NEUROSPHERES AS PREDICTIVE IN VITRO TEST FOR DEVELOPMENTAL NEUROTOXICANTS. K. Gassmann, T. D. Rockel, J. Abel, E. Fritsche. Institut fuer umweltmedizinische Forschung at the Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

P201-017A CO-CULTURE APPROACH TO NEW IN VITRO SKIN SENSITIZATION ASSAYS COMBINING EPISKIN AND U937 OR THP-1. A. Staropoli (1), M. Ishikawa (2), J. M. Ovigne

(1), T. Ashikaga (2), J. Robert (1), H. Itagaki (2), Y. Kohno (2), J. R. Meunier (1). (1) L’Oréal, Aulnay-sous-Bois, France, Metropolitan; (2) Shiseido, Yokohama, Japan.

P201-018NOVEL BIOMARKERS IN DENDRITIC CELLS CONTRIBUTE IN UNDERSTANDING THE SKIN SENSITIZATION PROCESS. N. Lambrechts, J. Hooyberghs, H. Witters, R. Van Den Heuvel, I. Nelissen, G. Schoeters. VITO nv, Mol, Belgium

P201-019THE USE OF THERMOLUMINESCENCE ENDPOINTS ON PHOTOSYNTHETIC ORGANISMS EXPOSED TO ENVIRONMENTAL CHEMICALS. G. Repetto (1), J. L. Zurita

(2), M. Roncel (3), J. M. Ortega (3). (1) National Institute of Toxicology and Forensic Sciences and University Pablo de Olavide, Sevilla, Spain; (2) National Institute of Toxicology and Forensic Sciences., Spain; (3) Institute of Vegetal Biochemistry and Photosynthesis, Sevilla, Spain.

P201-020EVALUATION OF A SUBSTANCE´S INHIBITION EFFECT ON THE PPD INDUCED SKIN SENSITIZATION USING THE HUMAN MONOCYTIC LEUKAEMIA CELL LINE, THP-1. S. An, S. Kim, K. M. Jung, K. M. Lim, T. R. Lee, H. K. Kim. Amorepacific Corporation R&D Center, Youngin, Korea, Republic of

P201-021EFFECTS OF RECREATIONAL DRUGS ON NEURITE OUTGROWTH IN PC12 CELLS. T. Yamamoto, A. Kaizaki, S. Tanaka, S. Numazawa, T. Yoshida. Showa University, Shinagawa-ku, Japan

P201-022IDENTIFICATION OF PROHAPTENS BY P38 MAPK ACTIVATION IN THP-1 CELLS. M. Mitjans (1), V. Galbiati (2), L. Lucchi (2), M. Marinovich (2), C. L. Galli (2), E. Corsini (2). (1) Facultatd de Farmacia, Universitat de Barcelona, Barcelona, Spain; (2) Università degli Studi di Milano, Milano.

P201-023DEVELOPMENT OF MULTIPARAMETRIC CELL-BASED PROTOCOL TO ASSESS AND CLASSIFY HEPATOTOXICITY POTENTIAL OF DRUGS. J. V. Castell (1), L. Tolosa

(2), S. Pinto (3), M. T. Donato (1), J. E. O’connor (3), M. J. Gómez-Lechón (2). (1) Universidad de Valencia, Valencia, Spain; (2) Fundacion para la Investigacion del Hospital La Fe, Valencia, Spain; (3) Unidad Mixta CIPF-UVEG, Valencia, Spain.

P201-024PREDICTION OF ACUTE ORAL TOXICITY WITH THE BALB/C 3T3 NRU CYTOTOXICITY ASSAY: EXPERIENCES FROM ROUTINE TESTING. A. Schrage, S. N. Boehn, M. Schulz, B. Van Ravenzwaay, R. Landsiedel. BASF SE, Ludwigshafen, Germany

P201-025MCMB LIVER MODEL FOR DRUG METABOLISM PREDICTION. B. Vinci (1), C. Duret (2), D. Mazzei (1), J. M. Wilkinson (3), P. Maurel (2), A. Ahluwalia (1). (1) Centro di Ricerca Interdipartimentale “E. Piaggio”, Università di Pisa, Pisa, Italy; (2) Inserm U632-IRB, Montpellier, France; (3) Kirkstall Ltd, The Sheffield BioIncubator, sheffield, United Kingdom.

P201-026EVALUATION OF BIS-(2-ETHYLHEXYL) PHTHALATE TOXICITY USING ALTERNATIVE SYSTEMS. A. Peropadre (1), Ó. Herrero (1), P. Fernández Freire (1), J. M. Pérez Martín (1), E. De La Peña (2), M. J. Hazen (1). (1) Universidad Autónoma de Madrid, Madrid, Spain; (2) Consejo Superior de Investigaciones Científicas.

P201-027IMPROVMENT OF CLONOGENIC ASSAYS (CFU-GM, CFU-MK, BFU-E) IN CYNOMOLGUS MONKEY FOR IN VITRO MYELOTOXICITY ASSESSMENT. M. Le Mercier (1), Y. Sibiril (1), A. Beamonte (2), N. Claude (2), D. Parent-Massin (1). (1) université de bretagne occidentale, Brest Cedex 3, France, Metropolitan; (2) Servier Group.

P201-028IN VITRO INVESTIGATIOIN OF EFFICACY OF NEW REACTIVATORS OF CHOLINESTERASE IN TABUNE INHIBITED CHE AND ACHE. C. Dishovsky, I. Petrova, I. Samnaliev. Military Medical Academy, Sofia, Bulgaria

BARCELONAIUTOX 2010


55

P201-029IN VITRO ALTERNATIVE PHOTOSENSITIZATION ASSAY USING HUMAN MONOCYTIC LEUKEMIA CELL LINE, THP-1. S. Kim, S. An, T. R. Lee, H. K. Kim. Amorepacific Corporation R&D Center, Yongin, Korea, Republic of

P201-030EVALUATING THE MICRONUCLEUS INDUCTION POTENTIAL FOR THE GENOTOXICITY ASSAY USING THE KERASKINTM HUMAN SKIN MODEL. H. S. Jung, Y. H. Ryu, S. H. Lee. Research institute, Modern Cell & Tissue Technologies, Inc., Seoul, Korea, Republic of

P201-031ALTERNATIVE IN-VITRO PHOTOTOXICITY TEST USING RECONSTRUCTED SKIN MODEL, KERASKINTM. Y. H. Ryu, H. S. Jung, S. H. Lee. Research Institute, Modern Cell & Tissue Technologies, Inc., Seoul, Korea, Republic of

P201-032OPTIMIZED IN-VITRO SKIN IRRITATION TEST USING RECONSTRUCTED HUMAN SKIN EQUIVALENT MODEL, KERASKINTM. Y. H. Ryu (1), K. M. Jung (2), S. H. Lee

(1), K. M. Lim (2), B. H. Kim (3). (1) Research Institute, Modern Cell & Tissue Technologies, Inc., Seoul, Korea, Republic of; (2) R&D Center, Amorepacific Co., Yongin, Korea, Republic of; (3)

Keimyung University, Daegu, Korea, Republic of.

P201-033THE COLIPA STRATEGY FOR THE DEVELOPMENT AND EVALUATION OF NOVEL ALTERNATIVE METHODS FOR THE IDENTIFICATION OF SKIN SENSITIZERS. P. Aeby (1), T. Ashikaga (2), S. Bessou-Touya (3), A. Schepky (4), F. Gerberick (5), P. Kern (6), M. Marrec-Fairley (1), G. Maxwell (7), J. M. Ovigne (8), H. Sakaguchi (9), K. Reisinger (10), M. Tailhardat (11), S. Teissier (8), P. Winkler (12). (1) Colipa, Brussels, Belgium, Brussels, Belgium; (2) Shiseido Research Centre, Yokohama-Shi, Japan; (3) Pierre Fabre, Castres, France; (4)

Beiersdorf, Hamburg, Germany; (5) The Procter & Gamble Company, Cincinnati, OH, USA; (6) The Procter & Gamble Company, Strombeek-Bever, Belgium; (7) Unilever, Sharnbrook, UK; (8) L’Oréal, Aulnay sous Bois, France; (9) Kao Corporation, Tochigi, Japan; (10) Henkel AG & Co, Düsseldorf, Germany; (11) LVMH Recherche, Saint Jean de Braye, France; (12) Petra Winkler, Johnson & Johnson, Neuss, Germany.

P201-034IN VITRO SCREENING METHOD FOR GASTROTOXICITY USING MUCIN LAYER. J. Ha (1), S. C. Park (2), H. Kwon (3). (1) Department of Food and Nutrition, Seoul National University, Seoul, Korea, Republic of, Seoul, Korea, Republic of: (2) Department of Eletronical Engineering, Seoul National University, Seoul, Korea, Republic of; (3) Department of Food and Nutrition, and Research Institute of Human Ecology, Seoul National University, Seoul, Korea, Republic of.

P201-035VALIDATION OF PORCINE CORNEAL OPACITY AND PERMEABILITY ASSAY AS AN ALTERNATIVE TO EYE IRRITATION TESTSJ. H. Han (1), S. H. Seok (2), Y. R. Na (1), T. H. Kim (1), H. Jung (1), C. H. Lim (3), J. H. Che (4), J. H. Park (1). (1) Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Korea, Republic of; (2) Institute for Experimental Animals, College of Medicine, Seoul National University; (3) National Institute of Toxicological Research, Seoul, Korea; (4) Department of Experimental Animal Research, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.

P201-036COMPARISON OF RECONSTRUCTED HUMAN SKIN MODELS WITH HUMAN AND PIG SKIN IN IN-VITRO PERCUTANEOUS ABSORPTION. S. H. Seok (1), J. H. Han (2), Y. R. Na (2), T. H. Kim (2), H. Jung (2), C. H. Lim (3), J. H. Che (4), J. H. Park (1). (1) Institute for Experimental Animals, College of Medicine, Seoul National University, Seoul, Korea, Republic of; (2) Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University; (3) National Institute of Toxicological Research, Seoul, Korea; (4) Department of Experimental Animal Research, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.

P201-037MITOCHONDRIAL TOXICITY IN VITRO INDUCED BY GOLD(III)-COMPLEXES. F. Chiara, A. Nicolli, A. Gambalunga, A. Rasola, M. Mongillo, L. Ronconi, D. Fregona, A. Trevisan. University of Padova, Padova, Italy

P201-038PROFILING THE TOXICITY OF NEW DRUGS: A NON ANIMAL-BASED APPROACH INTEGRATING TOXICODYNAMICS AND BIOKINETICS. B. Lauer, G. Truisi, S. O. Mueller, P. G. Hewitt. Merck Serono Research, Darmstadt, Germany

P201-039ROLE OF ORGANIC CATION MEDIATED TRANSPORT AND OXIDATIVE STRESS IN THE SYNEPHRINE INDUCED-TOXICITY IN FRESHLY ISOLATED CARDIOMYOCYTES. L. G. Rossato, V. M. Costa, P. G. Pinho, F. Carvalho, H. Carmo, M. L. Bastos, F. Remião. REQUIMTE (Rede de Química e Tecnologia), Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal, Porto, Portugal

P201-040WHOLE-GENOME TRANSCRIPTOMICS REVEALS A DISTINCT RESPONSE BETWEEN ULTRAPURE PCBS IN CULTURED HUMAN MONONUCLEAR CELLS. B. Wens, P. De Boever, G. Schoeters. Flemish Institute for Technological Research (VITO), Mol, Belgium

P201-041ISOLATION AND PRIMARY CULTURE OF HUMAN PROXIMAL RENAL TUBULAR EPITHELIAL CELLS: APPLICATION TO THE STUDY OF COCAINE-INDUCED NEPHROTOXICITY. M. J. Valente (1), P. Guedes De Pinho (1), R. Henrique (2), F. Carvalho (1), M. L. Bastos (1), M. Carvalho (3). (1) REQUIMTE-Toxicology Department, Porto, Portugal; (2)

Portuguese Oncology Institute-Porto, Porto, Portugal; (3) REQUIMTE-Toxicology Department & CEBIMED, Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal.

P201-042UPDATE OF THE COLIPA EYE IRRITATION TASK FORCE STRATEGY AND PROGRAMME FOR DEVELOPMENT OF IN VITRO METHODS. B. Le Varlet (1), N. Alepee (2), S. Bessou-Touya (3), A. De Smedt (4), B. De Wever (5), J. Harbell (6), P. Jones (7), P. Mcnamee (8), M. Marrec-Fairley (9), U. Pfannenbecker (10), M. Tailhardat (11), F. Van Goethem (4). (1) Links Ingenierie, (2) L’Oréal, (3) Laboratoire Pierre Fabre, (4) Johnson & Johnson Pharmaceutical Research & Development, (5) Henkel, (6) Mary Kay Inc, (7) Safety And Environmental Assurance Centre, Unilever, (8) The Procter & Gamble Company, (9) COLIPA, (10) Beiersdorf, (11) LVMH., France

P201-043A PHYSICOCHEMICAL AND BIOLOGICAL ASSESSMENT OF UV FILTERS AS SUBSTANCES AND FORMULATED PRODUCTS. A. Smyth. Athlone Institute of Technology, Westmeath, Ireland

P201-044A RAPID AND REDUCED CELL DEMANDING TEST FOR SCREENING OF THE EFFECTS OF TEST COMPOUNDS ON PHASE I AND II ACTIVITIES IN PLATEABLE HUMAN CRYOHEPS. E. Alexandre (1), A. Baze (1), C. Desbans (1), C. Parmentier (1), B. Heyd (2), G. Mantion (3), J. C. Weber (4), P. Bachellier (5), L. Richert (1), L. Richert (6). (1) KaLy-Cell, Illkirch, France, Metropolitan; (2) Service de Chirurgie Viscérale et Digestive � Centre de Transplantation Hépatique, EA 2SBP, IFR 133, Besançon, France, Metropolitan; (3) Service de Chirurgie Viscérale et Digestive � Centre de Transplantation Hépatique, EA2SBP, IFR 133, Besançon, France, Metropolitan; (4) Clinique de l‘Orangerie, Strasbourg, France, Metropolitan; (5) Centre de Chirurgie Viscérale et de Transplantation, EA 2SBP, IFR 133, Hautepierre, France, Metropolitan; (6) Laboratoire de Toxicologie Cellulaire, EA 2SBP, IFR133, Besançon.


56

P201-045ENCAPSULATED RHODANESE WITH TWO NEW SULFUR DONORS IN CYANIDE ANTAGONISM. I. Petrikovics (1), G. Kuzmitcheva (1), D. Haines (1), M. Budai (1), J. Childress (1), A. Nagy (1), G. Rockwood (2). (1) SHSU, Huntsville, United States; (2) US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, United States. P201-046THE COLIPA SKIN METABOLISM PROJECT: DO IN VITRO ALTERNATIVES COMPRISE ADEQUATE DETOXIFICATION CAPACITIES FOR CHEMICAL TESTING IN SKIN?. C. Götz (1), K. Ruwiedel (1), R. Pfeiffer (1), U. Hübenthal (1), R. Edwards (2), P. Carmichael (3), P. Aeby (4), C. Goebel (5), C. Pease (3), E. Fritsche (1). (1) IUF gGmbH, Düsseldorf, Germany; (2) Imperial College London; (3) Unilever, Bedford, UK, (4) Procter and Gamble, Marly, Switzerland; (5) Procter and Gamble, Darmstadt, Germany.

P201-047TOXICITY OF DIFFERENT FRACTIONS OF MASCANIA RIGIDA: IN VITRO EVALUATION. L. C. Cunha (1), A. C. D. Rodas (2), M. Haraguchi (3), S. L. Górniak (1). (1) School Of Veterinary Medicine And Animal Sciences, University Of São Paulo, Brazil; (2) Institute Of Nuclear Energy Research - Biotechnology Centre, São Paulo, Brazil, (3) Biological Institute, São Paulo, Brazil.

P201-048AN ISOLATED AND PERFUSED ORGAN APPROACH TO VALIDATE BIOMARKERS OF TOXICITY IDENTIFIED IN METABONOMICS STUDIES. V. Tagliatti, J. M. Colet, R. Conotte. University of Mons, Mons, Belgium

P201-049TRAC GENE EXPRESSION ANALYSIS IN IN VITRO DRUG METABOLISM SCREENING. J. Rautio, J. Kotimaa, M. Sirkiä. PlexPress Oy, Helsinki, Finland

P201-050DIRECT PEPTIDE REACTIVITY ASSAY USING SPECTROPHOTOMETRIC METHOD FOR PREDICTION OF SKIN SENSITIZATION POTENTIAL OF CHEMICAL HAPTENS. Y. H. Jeong, S. An, T. R. Lee. Amorepacific Corporation R&D center, Yongin-si, Korea, Republic of

P201-051PROGRAMMED CELL DEATH INDUCED BY LOVASTATIN AND TOCOPHEROL IN HUMAN COLORECTAL CARCINOMA CELL LINE HT29. M. Rezaei (1), H. R. Galedari (2), H. Kalantari (1), Y. Arast (1). (1) Dept. of Toxicology and Pharmacology, Pharmacy School, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Islamic Republic of Iran, Ahvaz, Iran (Islamic Republic of); (2) Genetics Department, Faculty of Science, Shahid Chamran University, Ahvaz, Islamic Republic of Iran.

P201-052IN VITRO TOXICOLOGICAL EVALUATION OF SELECTED NATURAL PRODUCTS. S. Winters. Athlone Institute of Technology, Athlone, Ireland

P201-053HIGH-CONTENT ANALYSIS OF OXYGEN REACTIVE SPECIES AND OXIDATIVE STRESS FOR TOXICOLOGY IN VITRO. S. Pinto, A. Gomes, D. Laura, H. Guadalupe, J. E. O’connor. Centro de Investigación Príncipe Felipe and Universidad de Valencia, Valencia, Spain

P201-054NOVEL HERMETIC CELL CULTURE CONTAINERS (PETAKA) AND CYTOMIC ASSAYS FOR TESTING SUSTAINED IN VITRO TOXICITY AND GENERAL CELL BIOLOGICAL RESEARCH. G. Herrera (1), L. Díaz (1), E. Barberá-Guillem (2), J. E. O’connor (1). (1) Centro de Investigación Príncipe Felipe, Valencia, Spain; (2) Celartia Europe.

P201-055AUTOMATED METHOD TO QUANTIFY FORMATION AND REPAIR OF DNA STRAND BREAKS. M. Moreno-Villanueva (1), T. Eltze (1), D. Dressler (2), J. Bernhardt (2), A. Buerkle (1). (1) University of Konstanz, Konstanz, Germany; (2) Biotesys.

P201-056DEVELOPMENT OF A HUMAN LUNG MODEL SYSTEM FOR THE IDENTIFICATION OF CHEMICAL RESPIRATORY ALLERGENS IN VITRO. E. Weber (1), S. Szameit (1), L. Farmer (1), C. Höpfner (1), M. Cezanne (1), M. Singal (2), L. Jones (2), L. Smith (2). (1) Seibersdorf Labor GmbH, Seibersdorf, Austria; (2) Research Institute for Fragrance Materials, Inc, Woodcliff Lake, United States.

P201-057WHAT COMBINATION EFFECTS CAN WE EXPECT FROM AMPHETAMINE DESIGNER DRUGS?. D. Silva (1), E. Silva (2), H. Carmo (3). (1) Faculty of Medicine, University of Porto, Porto, Portugal; (2) The School of Pharmacy, University of London, Centre for Toxicology, London, United Kingdom; (3) REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal.

P201-058EXPERIENCES IN ROUTINE TESTING FOR EYE IRRITATION: COMPARING RESULTS FROM BCOP (OECD TG 437) AND HET-CAM TO IN VIVO DATA. A. Schrage, A. O. Gamer, S. Böhn, B. V. Ravenzwaay, R. Landsiedel. BASF SE, Ludwigshafen, Germany

P201-059ESTROGEN RECEPTOR TRANSACTIVATION ASSAYS: COMPARING HELA-CELL- AND YEAST-BASED METHODS. S. N. Böhn, H. A. Hüner, J. Knickel, C. Woitkowiak, B. V. Ravenzwaay, R. Landsiedel. BASF SE, Ludwigshafen, Germany

P201-060CD34+ CELL EXPANSION MODEL FOR THE IN VITRO ASSESSMENT OF HAEMATOTOXICITY. K. Hedley, C. Hougham, J. Dykens. Pfizer Ltd, Sandwich, United Kingdom

P201-061IN VITRO EVALUATION OF THE DERMAL IRRITATION OF ANTIOXIDANT EXTRACTS. B. Díaz Reinoso (1), N. González López (1), D. Rubert (2), A. Moure (1), H. Domínguez (1), M. P. Vinardell (2), M. Mitjans (2), J. C. Parajó (1). (1) University of Vigo, Ourense, Spain; (2) Universitat de Barcelona.

P201-062REPEATED EXPOSURE OF A549 CELLS WITH CIGARETTE MAINSTREAM SMOKE IN THE CULTEX® RADIAL FLOW SYSTEM. S. Röker, M. Aufderheide, N. Möhle, O. Krischenowski. CULTEX Laboratories GmbH, Hannover, Germany

P201-063AN INTERLABORATORY STUDY TO EVALUATE THE REPRODUCIBILITY OF TOXICOGENOMICS DATASETS. L. Gribaldo (1), D. Scott (2), A. Devonshire (2), Y. Adeleye (3), M. Sacco (1), M. Schutte (2), R. Rodrigues (1), T. Wilkes (2), M. Fabbri (1), M. Whelan (1), N. Skinner (4), A. Bennett (5). (1) IHCP-E.C., Ispra, Italy; (2) LGC, Teddington, United Kingdom; (3) Unilever, Bedford, United Kingdom; (4) Agilent, United Kingdom; (5) FRAME, University of Nottingham UK.

P201-064IN VITRO TOXICITY STUDY OF SYNTHETIC AND NATURAL ALKENYL GLUCOSINOLATE HYDROLYSIS PRODUCTS ON CHO1 AND MCL5 CELL LINES. N. H. Abd Kadir, J. T. Rossiter, N. J. Gooderham. Imperial College of London, London, United Kingdom

BARCELONAIUTOX 2010


57

P201-065ALPHA-FETOPROTEIN: A SENSITIVE TERATOGENIC MARKER IN MOUSE EMBRYONIC STEM CELL. D. Pamies, N. Vicente-Salar, M. A. Sogorb, E. Roche, J. A. Reig. Instituto de Bioingeniería, Elche, Spain

P201-066NEUROPATHY TARGET ESTERASE (NTE) AS POTENTIAL BIOMARKER OF EMBRYOTOXICITY DURING EARLY STAGES OF DEVELOPMENT. A. C. Romero, D. Pamies, C. Estevan, E. Vilanova, M. A. Sogorb. Instituto de Bioingenieria. Universidad Miguel Hernandez de Elche., Elche, Spain

P201-067MEETING REQUIREMENTS OF THE NEW OECD TG FOR IN VITRO SKIN IRRITATION TESTING: REPRODUCIBILITY OF THE EPIDERM SKIN IRRITATION TEST (EPIDERM-SIT) FOLLOWING THE ECVAM VALIDATION AND ACCEPTANCE AS A FULL REPLACEMENT METHOD. M. Klausner, W. Deng, J. Kubilus, H. Kandarova, P. Hayden, J. Sheasgreen. MatTek Corporation, Ashland, United States

P201-068REPRODUCIBILITY OF THE MATTEK OCULAR IRRITATION TEST (EPIOCULARTM-OIT) IN RESPONSE TO THE COLIPA/ECVAM REACH INITIATIVE. Y. Kaluzhny, H. Kandarova, S. Letasiova, P. Hayden, J. Sheasgreen. MatTek Corporation, Ashland, United States

P201-069CUTANEOUS WOUND HEALING IN THE EPIDERM-FT FULL THICKNESS IN VITRO HUMAN SKIN MODEL. S. Letasiova, P. Hayden, G. Stolper, A. Armento, C. Cooney, M. Klausner. MatTek Corporation, Bratislava, Slovakia (Slovak Republic)

P201-070EVALUATION OF PLASMACYTOID DENDRITIC CELL-BASED ASSAY FOR CHEMICAL ALLERGENICITY SCREENING. S. Ayehunie, H. Kandarova, M. Child, P. Hayden, M. Klausner, S. Letasiova, J. Sheasgreen. MatTek Corporation, Ashland, United States

P201-071USE OF THE ORGANOTYPIC EPIVAGINALTM TISSUE MODEL TO SCREEN IRRITATION POTENTIAL OF FEMININE HYGEINE INGREDIENTS AND FORMULATIONS. H. Kandarova, S. Ayehunie, C. Cannon, K. Larosa, P. Hayden, M. Klausner. MatTek, Bratislava II, Slovakia (Slovak Republic)

P201-072AN IN VITRO HUMAN AIRWAY MODEL (EPIAIRWAY) FOR TOXICITY AND DRUG DELIVERY SCREENING OF INHALED FORMULATIONS. P. Hayden, H. Kandarova, G. Jackson, M. Klausner. MatTek Corporation, Ashland, United States

P201-073A NEW IN VITRO MODEL OF AIR-BLOOD BARRIER FOR THE STUDY OF THE TRANSLOCATION AND THE TOXICITY OF NANOPARTICLES. S. Dekali (1), F. Rogerieux

(1), D. Elgrabli (1), G. Lacroix (1), P. Rat (2), S. Achard (3). (1) INERIS (Institut National de l’Environnement industriel et des RISques)-FRANCE, Verneuil-en-Halatte, France; (2) Laboratoire Toxicologie CNRS C-TAC / Faculté de Pharmacie - Université PARIS-DESCARTES - FRANCE; (3) Laboratoire de Santé-publique Environnement / Faculté de Pharmacie - Université PARIS-DESCARTES - FRANCE.

P201-074CYTOTOXICITY VARIABLES IN HIGH-THROUGHPUT COMPUTER-VISION STUDIES. P. Héroux, Y. Li. McGill University, Montreal, Canada

P201-075EX VIVO LUNG CULTURE MODELS TO STUDY RESPIRATORY INFLAMMATION AND THEIR RELEVANCE FOR IN VIVO: AN INTERSPECIES COMPARISON. K. Sewald

(1), S. Seehase (1), S. Switalla (1), H. D. Lauenstein (1), C. Foerster (2), C. Schlumbohm (3), E. Fuchs (3), F. J. Kaup (3), N. Krug (1), F. Schaumann (1), A. Braun (1). (1) Fraunhofer ITEM, Hannover, Germany; (2) Nordstadtkrankenhaus Hannover; (3) German Primate Center.

P201-076IN VITRO EVALUATION OF POTENTIAL ENDOCRINE DISRUPTING EFFECTS OF SEVERAL HERBAL DIETARY SUPPLEMENTS. H. Gurer-Orhan, D. Uslu, Y. Toker, E. Bedir. EGE UNIVERSITY, IZMIR, Turkey

P201-077DEVELOPMENT OF INDUCIBLE SHRNA CELL MODELS FOR TOXICOLOGY SCREENING. J. Hitchcock (1), H. Zhu (2), L. Levy (1), C. Gardner (1), K. Plant (2), N. Plant (2). (1) Pfizer Ltd, Sandwich, United Kingdom; (2) University of Surrey, Guildford, United Kingdom.

P201-078ANTIOXIDANT ACTIVITY AND PHENOLIC ACID COMPOSITION OF SOUTH AFRICAN HERBAL REMEDIES. M. Gulumian (1), O. Nkwaner (1), J. Van Tonder (2), V. Steenkamp (2). (1) National Institute for Occupational Health, Johannesburg, South Africa; (2) University of Pretoria, Pretoria, South Africa.

P201-079POSSIBLE IMPROVEMENTS TO EMBRYONIC STEM CELL TEST (EST) USING MOLECULAR MARKERS OF CELL DIFFERENTIATION. C. Estevan, D. Pamies, A. C. Romero, E. Vilanova, M. A. Sogorb. Universidad Miguel Hernández de Elche, Elche, Spain

P201-080VALIDATION OF A HUMAN CELL BASED IN VITRO ANGIOGENESIS CO-CULTURE MODEL. J. R. Sarkanen, M. Mannerström, H. Vuorenpää, T. Ylikomi, T. Heinonen. Finnish Center for Alternative Methods, University of Tampere, Finland

P201-088DETERMINATION OF ABSORPTION AND BIOTRANSFORMATION OF BENZO[A]PYRENE IN A PERFUSION CO-CULTURE SYSTEM FOR PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS. D. A. Ouattara (1), S. H. Choi (2), Y. Sakai (2), C. Brochot (3). (1) UMR-CNRS 6600, Université Technologique de Compiègne, Compiègne, France; (2)

Institute of Industrial Science, University of Tokyo, Tokyo, Japan; (3) INERIS, Verneuil-en-Halatte, France.

P201-089ASSESSMENT OF CHEMICAL SKIN SENSITIZING POTENCY BY AN IN VITRO ASSAY BASED ON HUMAN DENDRITIC CELLS. N. Lambrechts, I. Nelissen, H. Witters, R. Van Den Heuvel, G. Schoeters, J. Hooyberghs. VITO nv, Mol, Belgium

P201-098 CHARACTERISATION OF CADMIUM CHLORIDE INDUCED MOLECULAR AND FUNCTIONAL ALTERATIONS IN AIRWAY EPITHELIAL CELLS. M. D. P. Prieto-Peraita (1), E. Forti (2), A. Bulgheroni (3), Y. Cetin (4), P. Jennings (2), W. Pfaller (2). (1) European Commission, Joint Research Centre, Ispra, Italy; (2) Innsbruck Medical University, Austria; (3) Polichem SA, Lugano-Pazzallo, Switzerland; (4) Ministry of Agriculture and Rural Affairs, Turkey.


58

P201-101PHYTOCHEMICALS MODULATING CELL PROLIFERATION AND PRO-INFLAMMATORY CYTOKINES IN VITRO. E. Codorean (1), L. Albulescu (1), E. Raducan (1), I. D. Popescu (1), C. Nichita (2), C. Tanase (1), R. Albulescu (1). (1) “Victor Babes” National Institute of Pathology, Bucharest, Romania; (2) Natl Inst Chem Pharm. R&D, Bucharest, Romania. P201-102ASSESSMENT OF A MODEL PROTOCOL FOR A HUMAN RECOMBINANT FULL LENGTH ESTROGEN RECEPTOR-ÁLPHA BINDING ASSAY - INITIAL STEPS TOWARDS VALIDATION. A. Freyberger (1), V. Wilson (2), M. Weimer (3), S. Tan (4), H. S. Tran (1), H. J. Ahr (1). (1) Bayer Schering Pharma AG, Wuppertal, Germany; (2) U.S. EPA, Office of Research and Development, NHEERL, United States; (3) German Cancer Research Center, Heidelberg, Ghana; (4) U.S. EPA, Office of Science Coordination and Policy, OPPTS, Washington, United States.

P201-103IN VITRO VAGINAL SAFETY SCREENING APPROACH FOR BATH AND BODY WASH PRODUCTS UTILIZING SKINETHIC HUMAN VAGINAL EPITHELIUM (HVE) MODEL. T. Re (1), A. Alonso (2), B. Bertino (2), G. E. Costin (3), A. De Brugerolle De Fraissinette (2), D. Orak (1), H. Inglis (3), K. Norman (3), P. Kazmi (1), H. Raabe (3), V. Srinivasan (1). (1) L’Oreal USA Products, Clark, NJ, USA, (2) Skinethic Laboratories, Nice, France, (3) Institute for In Vitro Sciences, Inc. (IIVS), Gaithersburg, MD, USA.

P202: MUTAGENICITY-GENOTOXICITY

P202-001SPONTANEOUS AND INDUCED FREQUENCY OF ANOMALIES IN THE HEAD SPERM MORPHOLOGY IN NMRI MICE. D. F. Arencibia Arrebola. Finlay Institute, Vice Presidency Of Research, Havana, Cuba.

P202-002EVALUATION IN VITRO OF THE RADIOPROTECTOR EFFECT OF THE AQUEOUS EXTRACT OF MANGIFERA INDICA L (VIMANG). L. A. Rosario Fernández (1), I. Guerra

(2), E. Almeida Valera (3), O. Leyva Peláez (1), A. Alonso (3), Y. Rodríguez (1). (1) Center for Pharmaceutical Chemistry. Havana. Cuba, Havana City, Cuba; (2) Center of bioprepred marine (CEBIMAR), Cuba;(3) Center for Aplication and Development of Nuclear Energy (CEADEN), Cuba

P202-003CYTOTOXICITY AND GENOTOXICITY OF DMPA ON FEMALE RATS. S. Bakry, N. Aseem, M. Montaser. Center for Genetic Engineering and Embryo Culture, Al Azhar University, Nasr City, Egypt

P202-004NUTRITIVE EVALUATION AND EFFECT OF MORINGA OLEIFERA LAM ON CLASTOGENIC POTENTIAL IN THE MOUSE. C. Promkum (1), C. Butryee (1), P. Kupradinun (2), S. Tuntipopipat (1). (1) Institute of Nutrition, Mahidol University, Phutthamonthon 4 Rd, Nakhon Pathom 73170, Thailand, Phutthamonthon, Thailand; (2) National Cancer Institute, Ministry of Public Health, Rama 6 Rd, Bangkok 10400, Thailand,

P202-005PERSISTENCE OF ESTRAGOLE DNA ADDUCT IN PRIMARY RAT HEPATOCYTES. A. Paini (1), G. Scholz (1), C. Bezecon (1), G. Guignard (1), T. Delatour (1), B. Schilter (1), P. J. Van Bladeren (1), I. M. Rietjens (2), M. Marin-Kuan (1). (1) Nestlé Research Center, Lausanne 26, Switzerland; (2) Wageningen University, Wageningen, Netherlands

P202-006EFFECT OF INDIGENOUS THAI PLANTS ON ETHYL CARBAMATE IN SOMATIC CELLS OF DROSOPHILA MELANOGASTER. M. Sukprasansap, S. Charoenkiatkul, K. Judprasong, K. Kangsadalampai. Institute of Nutrition, Mahidol University, Salaya, Putthamonthon, Nakhon Pathom, Thailand

P202-007THE ROLE OF OXIDATIVE DNA DAMAGE, DNA REPAIR, GSTM1, SOD2 AND OGG1 POLYMORPHISMS IN INDIVIDUAL SUSCEPTIBILITY TO BARRETT’S ESOPHAGUS. E. Kadioglu (1), S. Sardas (2), M. Ergun (1), S. Unal (1), A. E. Karakaya (1). (1) Gazi University, Ankara, Turkey; (2) , Istanbul, Turkey

P202-008IDENTIFICATION OF A MOUSE NOVEL GENE THAT WAS INDUCED UPON GENOTOXIC STRESS AND POTENTIALLY INVOLVED IN DNA DAMAGE RESPONSE OR REPAIR. Y. Wu (1), Y. Luan (1), X. Qi (1), T. Suzuki (2), J. Ren (1). (1) Center for Drug Safety Evaluation and Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., Shanghai, China; (2) Division of Cellular and Gene Therapy Products, National Institute of Health Sciences, Tokyo, Japan.,

P202-009GENOTOXICITY OF CLAYS WITH POTENTIAL USE IN BIOPOLYMERS FOR FOOD PACKAGING. A. K. Sharma, A. Mortensen, N. Hadrup, V. Jørgensen, M. L. Binderup. Technical University of Denmark, National Food Institute, Søborg, Denmark

P202-010MUTAGENICITY IN VITRO OF CARBENDAZIM. C. Garcia-Canton (1), R. S. Stafford (2), V. Caballero Gonzalez (3), S. P. Faux (1), A. Anadon Navarro (3), G. J. Phillips (1). (1) British American Tobacco, Southampton, United Kingdom; (2) Advanced Technologies (Cambridge) Ltd a wholly owned subsidiary of British American Tobacco Investments limited, Cambridge, United Kingdom; (3) University Complutense of Madrid,

P202-011A NEW GENOTOXICITY ASSAY BASED ON A CO-CULTURE OF L5178Y TK+/- AND HEPARG® CELL LINES. P. A. Torres, M. J. Almela, S. Lozano, J. F. García Bustos, E. Herreros. GlaxoSmithKline, R&D / Tres Cantos Medicines Development Campus, Tres Cantos, Spain

P202-012ASSESSMENT OF DNA DAMAGE IN THE PERIPHERAL LYMPHOCYTES OF PATIENTS WITH MULTIPLE SCLEROSIS BY THE COMET ASSAY. M. Baydar (1), S. Aydin (2), Ü. Ündeger (2), G. Orhan (3), F. Ak (3), N. Basaran (2). (1) Numune Education and Research Hospital, Ankara, Turkey; (2) Hacettepe University, Faculty of Pharmacy,, Ankara, Turkey;(3) Numune Education and Research Hospital,, Ankara, Turkey

P202-013GENOTOXICITY EVALUATION OF DIFFERENT DENTIN BONDING AGENTS BY COMET ASSAY. A. Kaya (1), Ü. Ündeger (2), H. Ömürlü (1), N. Basaran (2). (1) Gazi University, Faculty of Dentistry, Ankara, Turkey;(2) Hacettepe University, Faculty of Pharmacy, Ankara, Turkey

P202-014ASSESSMENT OF OXIDATIVE DNA DAMAGE OF THE FORMALDEHYDE-EXPOSED WORKERS. S. Aydin (1), H. Canpinar (2), A. Kars (2), M. Colakoglu (3), N. Basaran

(1). (1) Hacettepe University, Faculty of Pharmacy, Ankara, Turkey;(2) Hacettepe University, Faculty of Medicine,, Ankara, Turkey;(3) Republic of Turkey Ministry of Health, Section of Public Health, Ankara, Turkey

BARCELONAIUTOX 2010


59

P202-015EFFECT OF DMT1 GENE POLYMORPHISM ON PLACENTAL METAL LEVELS. Z. Kayaalti (1), D. Tekin (1), G. Mergen (1), M. Odabaşi (1), G. Kurtay (2), T. Söylemezoğlu (1). (1) Forensic Medicine, Ankara, Turkey;(2) Faculty of Medicine,

P202-016ASSESSMENT OF THE IN VIVO GENOTOXICITY OF A NEW FORMULATION OF THE BIOLARVICIDE BACTIVEC. A. Curbelo (1), A. Mancebo (1), T. Molier (2), M. E. Arteaga (1), C. González (1), R. Grandía (1), A. M. Bada (1), Y. Rivero (1), A. García (1), M. Legró (1), F. Contreras (1). (1) CENPALAB, La Habana, Cuba; (2) LABIOFAM, Cuba

P202-017NEW INSIGHT INTO PROPYLPARABEN IN VITRO TOXICITY: DNA OXIDATIVE DAMAGE. J. M. Pérez Martín, A. Peropadre, Ó. Herrero, P. Fernández Freire, V. Labrador, M. J. Hazen. Universidad Autónoma de Madrid, Madrid, Spain

P202-018NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX IN RIBOSOMES PLAYS A KEY ROLE IN PROTECTION AGAINST ADRIAMYCIN TOXICITY IN BUDDING YEAST. T. Takahashi, A. Naganuma. Graduate School of Pharmaceutical Sciences, Tohoku university, Sendai, Japan

P202-019EFFECT OF IL-6 -174 G/C POLYMORPHISM ON TOXIC METAL AND TRACE ELEMENT LEVELS IN PLACENTA. Z. Kayaaltı, D. Tekin, S. Yalçın, V. Aliyev, E. Söylemez, G. Kurtay, T. Söylemezoğlu. Ankara University, Ankara, Turkey

P202-020THE INDUCTION OF INTER-STRAND DNA CROSS-LINKS IN DIFFERENT TISSUES OF RATS AFTER PERCUTANEOUS APPLICATION OF SULPHUR MUSTARD (SM). R. Stetina, M. Jilkova, H. Svobodova. University of Defence, Hradec Kralove, Czech Republic

P202-021ASSESSMENT OF GENOTOXIC EFFECTS IN PATIENTS TREATED WITH TITANIUM ALLOY ENDOSSEOUS IMPLANTS OR MINIPLATES BY MICRONUCLEUS ASSAY. B. Karahalil, E. Kadıoglu, A. M. Tuzuner-Oncul, E. Cimen, E. Emerce, R. S. Kısnıscı. Gazi University, Ankara, Turkey

P202-022EVALUATION OF GENOTOXIC POTENTIAL OF ALOE VERA GEL VIA COMET ASSAY WITH MICE. O. K. Ulutaş (1), E. Durmaz (1), R. Güler (1), İ. Gürbüz (2), İ. Çok (1). (1) Gazi University Faculty of Pharmacy Department of Toxicology, Ankara, Turkey;(2) Gazi University Faculty of Pharmacy Department of Pharmacognosy,

P202-023EVALUATION OF THE EFFECTS OF PHTHALATES ON ANTIOXIDANT STATUS, P53 EXPRESSION AND OXIDATIVE DNA DAMAGE IN LEYDIG CARCINOMA CELLS AND PROTECTION BY SELENIUM COMPOUNDS. P. Erkekoglu (1), W. Rachidi (2), O. Gursoy Yuzugullu (3), B. Giray (1), M. Ozturk (3), A. Favier (2), F. Hincal (1). (1) hacettepe university, ankara, Turkey;(2) CEA Grenoble, Grenoble, France;(3) Centre de Recherche INSERM-Université Joseph Fourrier U823, Institut Albert Bonniot,, Grenoble, France

P202-024ON THE MECHANISM OF DEMETHYLATING AGENTS-INDUCED DNA DAMAGE. M. L. Orta Vázquez, I. Domínguez García, N. Pastor Carrillo, F. Cortés Benavides, S. Mateos Cordero. University of Seville, Seville, Spain

P202-025BURITI (MAURITIA FLEXUOSA) OIL: EVALUATION OF THE MUTAGENIC AND ANTIMUTAGENIC POTENTIAL BY THE MICRONUCLEUS TEST IN VIVO. J. Ribeiro (1), L. Antunes (1), J. Darin (1), A. Mercadante (2), M. D. L. Bianchi (1). (1) Faculdade de Ciências Farmacêuricas de Ribeirão Preto - Universidade de São Paulo, Ribeirão Preto, Brazil;(2) Faculdade de Engenharia de Alimentos - universidade de Campinas,

P202-026INVESTIGATION OF TOXIC EFFECTS OF OUTDOOR MINERAL DUSTS ON HUMAN LUNG EPITHELIAL CELLS (A549) IN VITRO. M. Könczöl (1), R. Gminski (1), E. Goldenberg

(2), S. Ebeling (2), I. Merfort (2), R. Gieré (2), V. Mersch-Sundermann (1). (1) University Medical Center Freiburg, Freiburg, Germany;(2) University Freiburg,

P202-027A BAYESIAN INTEGRATION MODEL OF IN-SILICO METHODS AND IN-VITRO ASSAYS FOR IMPROVED MUTAGENICITY PREDICTION. J. Li, S. Modi, S. Malcomber, C. Moore, A. Scott, P. Carmichael. Safety & Environmental Assurance Centre, Bedford, United Kingdom

P202-028TOXICOLOGICAL INVESTIGATION OF LASER PRINTER EMISSIONS - EFFECTS ON HUMAN CELLS. R. Gminski, T. Tang, R. Kuhn, M. Könczöl, C. Gründemann, V. Mersch-Sundermann. University Medical Center Freiburg, Freiburg, Germany

P202-029FREE RADICAL SCAVENGING AND ANTIOXIDANT POTENTIAL OF LUTEIN PREVENTING THE INDUCED DNA DAMAGE IN HEPG2 CELLS. J. M. Serpeloni (1), G. R. M. Barcelos (1), J. P. F. Angeli (2), A. Z. Mercadante (3), M. D. L. P. Bianchi (1), L. M. G. Antunes (1). (1) Faculdade de Ciências Farmacêuticas de Ribeirão Preto/Universidade de São Paulo, Ribeirão Preto, Brazil;(2) Universidade de São Paulo;(3) Universidade Estadual de Campinas,

P202-030ROLE OF AHR ON DNA DAMAGES IN LUNG EPITHELIAL CELLS EXPOSED TO CIGARETTE SIDESTREAM PARTICULATES. Y. Cheng (1), H. L. Lee (2), L. A. Li (2). (1) School of Medicine, China medical university, Taichung, Taiwan;(2) , Zhunan, Taiwan

P202-031GENOTOXIC DAMAGE, OXIDATIVE STRESS AND XENOBIOTIC METABOLISM CHANGES PRODUCED BY THE EXPOSURE OF THE COMPLEX MIXTURE OF TOLUENE, CHLOROFORM AND METHYLENE CHLORIDE. J. Belmont (1), E. Molina (1), A. López (1), L. Serrano (1), A. Martínez (1), R. Montero (1), E. Coballase (2), N. Cardenas (2), B. Huerta (2). (1) Instituto de Investigaciones Biomedicas. UNAM, Mexico D.F., Mexico;(2) Instituto Nacional de Pediatria, México D.F.

P202-032EFFECT OF SOME FLAVANONES ISOLATED FROM BOESENBERGIA PANDURATA ON DIETHYLNITROSAMINE-INITIATED EARLY STAGE OF RAT HEPATOCARCINOGENESIS. R. Wongpoomchai (1), S. Charoensin (2), C. Punvittayagul (1), W. Pompimon (3). (1) Chiang Mai University, Chiang Mai, Thailand;(2) Naresaun Phayao University,(3) Lampang Rajabhat University,

P202-033ASSESSMENT OF GENOTOXICITY OF SPINOSAD ON CAPSICUM ANNUUM USING THE COMET ASSAY. N. Kaya, S. Kocaoğlu, B. Kaya. Akdeniz University, Antalya, Turkey


60

P202-034BILASTINE: IMPURITIES SAFETY PROFILE. A. Alejandro (1), J. Arteche (2), F. Ledo (2), A. Leizea (1), M. T. Nuñez (2), P. Vilches (1), M. L. Lucero (2). (1) Gaiker Technological Center, ZAMUDIO, Spain;(2) FAES FARMA S.A, Leioa, Spain

P202-035ACUTE SYSTEMIC TOXICOLOGICAL AND MUTAGENIC EVALUATIONS OF A PROTEOLYTIC FRACTION FROM LATEX OF CARICA CANDAMARCENSIS. M. Villalba, A. Silva, C. Tagliati, G. Cassali, C. Salas, M. Lopes. Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

P202-036GENOTOXIC EFFECT OF 3-TESLA MAGNETIC RESONANCE IMAGE (MRI) IN HUMAN LYMPHOCYTES. J. W. Lee (1), Y. J. Kim (1), M. S. Kim (2), H. D. Woo (1), Y. H. Lee (1), H. W. Chung (1). (1) The Graduate School of Public Health, Institute of Health and Environment, Seoul National University, Seoul, Korea, Republic of;(2) Department of Radiology, National Cancer Center, Republic of Korea,

P202-037GENOTOXICITY OF LIQUID PRODUCTS FROM PYROLYSIS OF SEWAGE SLUDGE. A. Pillco (1), E. De La Peña (2), M. J. Hazen (3). (1) Biochemical Research Institute, University Major of San Andres (UMSA), Saavedra, 2224, La Paz, Bolivia, Madrid, Spain;(2) Laboratory of Environmental Mutagenesis, Environmental Sciences Center, Spanish National Research Council (CSIC), Serrano 115, 28006 Madrid, Spain, , Spain;(3) Department of Biology, Faculty of Sciences, Autonomous University of Madrid, Darwin 2, 28049, Madrid, Spain,

P202-038GENOTOXICITY ASSESSMENT BY MICRONUCLEUS ASSAY IN PERIPHERAL BLOOD LYMPHOCYTES AND BUCCAL EPITHELIAL CELLS OF CHILDREN WITH CHRONIC KIDNEY DISEASE. G. Cakmak Demircigil (1), B. Aykanat (1), K. Fidan (2), U. S. Bayrakci (3), B. Buyukkaragoz (2), H. Karakayali (4), M. Haberal (4), E. Baskin (3), N. Buyan (2), S. Burgaz (1). (1) Gazi University, Faculty Of Pharmacy, Department Of Toxicology, Ankara, (2) Gazi University, Faculty Of Medicine, Department Of Pediatric Nephrology, Ankara, (3) Baskent University, Faculty Of Medicine, Department Of Pediatric Nephrology, Ankara, (4) Baskent University, Faculty Of Medicine, Department Of General Surgery, Ankara.

P202-039BIOMONITORING IN CHILDREN EXPOSURE TO HEAVY METALS. C. Herrera Maldonado (1), M. E. Sánchez (1), C. Paz Y Miño (1), M. Segovia (2), C. Carrera (2), M. Arévalo (2), V. H. Espín (3), M. Novillo (3). (1) U.D.L.A.Instituto De Investigaciones Biomédicas, (2) Pontificia Universidad Católica Del Ecuador, (3) Universidad Central Del Ecuador.

P202-040GENOTOXICITY OF COMBINED EXPOSURE TO BENZ (E) ACEPHENANTHRYLENE AND UV-A BY USING HUMAN SKIN CELL LINE. D. Ali. Indian Institute of Toxicology Research,Lucknow, Lucknow, India

P202-041EVALUATION OF THE GENOTOXICITY OF NINE COMPOUNDS WITH SIGNIFICANT IN VITRO ANTICHAGASIC ACTIVITY. L. Arbillaga (1), L. San Miguel (1), M. López (1), M. J. Dávila (1), L. A. Corcuera (1), A. G. Gil (1), H. Cerecetto (2), M. González (2), A. López De Cerain (1). (1) University of Navarra, Pamplona, Spain;(2) University of la República, Montevideo, Uruguay

P202-042DETECTION OF CHROMOSOMAL ABERRATIONS IN CATTLE CELLS AFTER CONAZOLE FUNGICIDE TREATMENT. B. Holeckova, J. Dianovsky, K. Sivikova, M. Mesarc. Institute of Genetics, Kosice, Slovakia (Slovak Republic)

P202-043EFFECTS OF TWO SELECTED FUNGICIDES ON THE FREQUENCY OF SCE IN BOVINE PERIPHERAL LYMPHOCYTES. K. Sivikova, J. Dianovsky, B. Holeckova, M. Galdikova. Institute of Genetics, Kosice, Slovakia (Slovak Republic)

P202-044GENOTOXICIY AND OXIDATIVE DNA DAMAGE OF PHENAZINE 5,10- DIOXIDES AS BIOREDUCTIVE PRODRUGS FOR SOLID TUMOUR TREATMENT. L. A. Corcuera

(1), M. L. Lavaggi (2), L. Arbillaga (1), G. Pachón (3), M. Cascante (3), H. Cerecetto (2), M. González (2), A. López De Cerain (1). (1) University of Navarra, Pamplona, Spain;(2) University of the Republic, ;(3) University of Barcelona,

P202-045DNA DAMAGE AND OXIDATIVE STRESS IN CELL FISH LINE RTG-2 AFTER EXPOSURE TO PCB MIXTURE (PCB153, 138, 101, 118). L. Marabini, S. Fucile. Università degli Studi di Milano, Milano, Italy

P202-046ROLE OF PHASE I ENZYMES IN BENZO(A)PYRENE (BP)-DNA ADDUCT FORMATION IN NORMAL HUMAN MAMMARY EPITHELIAL CELLS (NHMECS). R. Divi, T. Einem, M. Shockley, M. Verma, M. Poirier. National cancer Institute, Bethesda, United States

P202-047IN SILICO PREDICTIONS OF AMES TEST MUTAGENICITY: AN INTEGRATED APPROACH. E. Deag, S. Modi, J. Li, S. Malcomber, C. Moore, A. Scott, P. Carmichael. Safety And Environmental Assurance, BEDFORD, United Kingdom

P202-048RECONSTITUTED HUMAN EPIDERMISES (RHES) USE FOR GENOTOXICITY TESTING. E. Andres, J. Molinari, N. Remoué, M. Lorencini, S. Medina, C. Barrichello. Natura Innovation, Paris, France

P202-049THE METHYLATING AGENT BUDESONIDE PROTECTS FROM m-AMSA INDUCED DNA DAMAGE IN HAMSTER CELL LINES. I. Domínguez, M. L. Orta, N. Pastor, S. Lladó, S. Martínez, V. García, F. Ramos, F. Cortés, S. Mateos. University of Seville Faculty of Biology, Seville, Spain

P202-050THE RELATIONSHIP OF DNA CROSS-LINKS INDUCED WITH SULPHUR MUSTARD (SM) IN HUMAN AND CHINESE HAMSTER CELL LINES TO THE CELL VIABILITY. P. Jost, H. Svobodová, S. Zemankova, R. Stetina. Faculty Of Military Health Sciences, University Of Defence, Czech Republic

P202-051MUTAGENIC AND GENOTOXIC EVALUATION OF A PHOTOSENSETIZING VERSUS A PHOTOTHERMAL AGENT IN CANCER TREATMENT: A COMPARATIVE IN VITRO STUDY. I. Gomaa (1), S. Ali (1), S. Abdelgaber (1), T. El-Tayeb (2), M. Abdel-Kader (1). (1) The German University in Cairo, New Cairo, Egypt;(2) The National Center for Laser Enhanced Sciences,

BARCELONAIUTOX 2010


61

P202-052ANTIMUTAGENICITY AND ANTIPROLIFERATIVE STUDIES OF LIPIDIC EXTRACTS FROM WHITE SHRIMP (LITOPENAEUS VANNAMEI) AND OCTOPUS (PARAOCTOPUS LIMACULATUS), AND THEIR INTERACTION WITH MUTAGENS. A. Burgos-Hernandez, G. Wilson-Sanchez, C. Moreno-Felix, M. M. Moreno-Vasquez, C. A. Velazquez-Contreras, L. Machi-Lara, M. L. Aldana-Madrid, J. M. Ezquerra-Brauer.Universidad de Sonora, Hermosillo, Mexico

P202-053STRATEGY FOR GENOTOXIC IMPURITIES: HAZARD IDENTIFICATION, RISK ASSESSMENT AND MANAGEMENT IN ANGELINI. C. Landolfi, L. Durando. ACRAF SpA -Angelini Santa Palomba Research Center, S. Palomba, Italy

P202-054CYTOGENETIC EFFECT OF MEDROXYPROGESTERONE ACETATE ON BONE MARROW CHROMOSOMES OF MICE. N. Aseem, S. Bakry, A. Abdullah. Zoology Department, Women College, for Arts, Science and Education, Ain Shams University, Heleopolis, Egypt

P202-055EXPOSURE TO RESIDENTIAL INDOOR AIR INDUCES HERITABLE DNA MUTATIONS IN MICE. J. Zhou, Y. Zhou, Y. Liu, W. Qiu, A. Li. Nanjing Medical University, Nanjing, China

P202-061DIVALENT METAL TRANSPORTER 1 POLYMORPHISM FREQUENCIES IN TURKISH POPULATION. M. Odabaşı, Z. Kayaaltı, D. Tekin, A. Karakuş, T. Söylemezoğlu. Ankara University, Institute of Forensic Medicine, Ankara, Turkey

P202-070GENOTOXIC EFFECTS OF DRINKING WATER EXPOSURE TO ARSENIC ON MEXICAN PEOPLE AND INFLUENCE OF GSTO1 AND AS3MT POLYMORPHISMS. A. Sampayo-Reyes (1), A. Hernández (2), N. El-Yamani (2), C. López-Campos (3), M. A. Bermudez De León (1), R. Marcos Dauder (2), S. González-Hernández (1). (1) Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social (IMSS),, Monterrey, Mexico;(2) Universitat Autonoma de Barcelona, Departament de Genetica i de Microbiologia, Bellaterra (Cerdanyola del Vallès) (Barcelona), Spain;(3) Unidad de Investigación Biomédica, Instituto Mexicano del Seguro Social, Torreón, Mexico, Mexico

P202-071IN VIVO MUTAGENICITY OF OCHARATOXIN A USING GPT DELTA RATS. Y. Ishii (1), D. Hibi (1), Y. Suzuki (1), M. Jin (1), N. Masui (2), T. Nohmi (3), Y. Konishi (4), T. Umemura (1), A. Nishikawa (1). (1) National Institute of Health Sciences, Division of Pathology, Tokyo, Japan;(2) Japan SLC, Incorporated;(3) National Institute of Health and Sciences, Division of Genetics and Mutagenesis, (4) National Institute of Health and Sciences, Division of Microbiology,

P202-072EVALUATION OF GENOTOXICITY OF EPHEDRAE HERBA THROUGH A BATTERY OF THREE GENETIC TOXICOLOGY ASSAY. J. Y. Kim (1), H. J. Cho (1), S. M. Back (1), J. Y. Yang (1), E. J. Oh (1), S. J. Park (2), B. S. Min (3), J. I. Huh (1). (1) Korea Institute of Toxicology, Daejeon, Korea, Republic of;(2) College of Veterinary Medicine, Kyungpook National University, ;(3) College of Pharmacy, Catholic University of Daegu,

P203: CARCINOGENICITY

P203-001FASTING ATTENUATES Γ-RAY RADIATION AND DRUG TOXICITY IN MICE. J. X. Li (1), J. Tong (1), S. N. Zhu (1), X. L. Gu (1), L. Song (1), H. L. Zhong (1), W. L. Fan (2). (1) School of Radiation Medicine and Public Health, Medical College of Soochow University., Suzhou, China;(2) HOPE INDUSTRY&TRADE CO.,LTD, Tianjing, China

P203-002ROLE PLAYED BY DDT-DERIVATIVE PESTICIDES AND INSULIN-LIKE GROWTH FACTOR 1 (IGF-I) IN BLADDER CANCER RISK. L. D. Boada (1), P. Navarro-Medina (2), M. Zumbado (1), E. E. Álvarez-León (2), M. Almeida-González (1), G. Hernández-Rodríguez (1), O. P. Luzardo (1). (1) University of Las Palmas de Gran Canaria and Instituto Canario de Investigación del Cáncer, Las Palmas de Gran Canaria, Spain;(2) Canary Health Service and Instituto Canario de Investigación del Cáncer, Las Palmas de Gran Canaria, Spain

P203-003PREPUBERTAL GENISTEIN EXPOSURE SUPPRESSES MAMMARY CANCER DEVELOPMENT AND ALTERS PROTEOMIC SIGNATURE IN ADULT RATS. C. Lamartiniere, J. Wang. University of Alabama at Birmingham, Birmingham, United States

P203-004THE G12 FAMILY PROTEINS UPREGULATE MATRIX METALLOPROTEINASE-2 VIA P53 LEADING TO HUMAN BREAST CELL INVASION. A. Moon (1), E. S. Kim (1), J. B. Jeong (1), S. Kim (1), K. M. Lee (2), E. Ko (2), D. Y. Noh (2), K. T. Hwang (3), J. H. Ha (4), C. H. Lee (5), S. G. Kim (6). (1) Duksung Women’s University, Seoul, Korea, Republic of;(2) Seoul National University Hospital, Korea, Republic of;(3) Seoul National University Boramae Hospital, Korea, Republic of (4) University of Oklahoma, United States;(5) Hanyang University, Korea, Republic of;(6) Seoul National University, Korea, Republic of

P203-005CHRONIC TOXICITY AND CARCINOGENICITY OF 95% ISOCARBOPHOS IN RATS. X. Zhang, X. Jia, N. Li. Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China

P203-006DIHYDROARTEMISININ INHIBITS PMA-INDUCED MATRIX METALLOPROTEINASE-9 ACTIVATION THROUGH OF PKC ALPHA/RAF/MAPKS AND NF-KB/AP-1-DEPENDENT MECHANISMS. Y. P. Hwang (1), H. J. Yun (2), H. G. Jeong (1). (1) Chungnam National University, Daejeon, Korea, Republic of;(2) Chosun University, Korea, Republic of

P203-007STRAIN DIFFERENCES OF THE EFFECT OF BENZENE EXPOSURE: MICROARRAY STUDY OF THE BONE MARROW IN C57BL/6 AND C3H/HE MICE. Y. Hirabayashi (1), B. I. Yoon (2), K. Igarashi (1), Y. Kodama (1), K. Sekita (1), T. Kaneko (1), J. Kanno (1), T. Inoue (1). (1) National Insitute of Health Sciences, Tokyo, Japan;(2) Kangwon National University, Chuncheon, Korea, Republic of

P203-008EXPRESSION OF THE FHIT TUMOR SUPPRESSOR GENE IS INHIBITED BY AFLATOXIN B1 IN HUMAN LIVER CELLS. R. Jossé, A. Fautrel, A. Guillouzo, M. A. Robin. INSERM UMR991, Rennes, France

P203-009IN VITRO ANTIPROLIFERATION, CYTOTOXICITY AND APOPTOTIC INDUCTION OF RICE BRAN EXTRACTS IN HUMAN BREAST CANCER CELL LINE. R. Chunhabundit

(1), R. Kongkachuichai (2), S. Srisala (1), Y. Visetpanit (1). (1) Faculty Of Medicine At Ramathibodi Hospital, Mahidol University, BANGKOK, Thailand (2) Institute Of Nutrition, Mahidol University. BANGKOK, Thailand


62

P203-010A PHARMACOTOXICOLOGICAL SCREENING FOR A SEMISOLID FORMULATION WITH BETULINIC ACID APPLIED ON A CHEMICAL MOUSE MELANOMA MODEL. S. A. Ciurlea (1), A. Muresan (1), E. Csányi (2), S. Berkó (2), C. A. Dehelean (1). (1) University of Medicine and Pharmacy Victor Babes Timisoara, Timisoara, Romania;(2) University of Szeged, Szeged, Hungary

P203-011INCREASED OXIDATIVE/NITROSATIVE STRESS AND DECREASED ANTIOXIDANT ENZYME ACTIVITIES IN PROSTATE CANCER. A. Eken (1), O. Erdem (1), Z. Arsova-Sarafinovska (2), A. Savaşer (1), A. Sayal (1), A. Dimovski (2), Y. Özgök (1), A. Aydın (1).(1) Gülhane Military Medical Academy, Ankara, Turkey, ANKARA, Turkey;(2) , Macedonia

P203-012MIR-494 AND MIR-22 REGULATE PTEN EXPRESSION IN TRANSFORMED CELLS INDUCED BY ANTI-BENZO[A]PYRENE-7,8-DIOL-9,10-EPOXIDE. Y. Jiang (1), L. Liu (1), A. Greenlee (2). (1) Guangzhou Medical University, Guangzhou, China;(2) The Jackson Laboratory,

P203-013ASSESSMENT OF SUPEROXIDE DISMUTASES IN TISSUE AND BLOOD SAMPLES OF PRIMARY EPITHELIAL OVARIAN CANCER PATIENTS. A. Caglayan (1), B. Giray (1), F. Hıncal (1), D. C. Katlan (2), B. Sayal (2), M. C. Salman (2), Z. S. Tuncer (2), K. Yüce (2). (1) Hacettepe University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey, ANKARA, Turkey;(2) Hacettepe University, Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey,

P203-014IN VITRO SCREENING FOR THE CARCINOGENICITY OF NINE ORIENTAL HERBAL MEDICINES. H. Kam, H. J. Kang, S. H. Kim, M. O. Lee. Seoul National University, Seoul, Korea, Republic of

P203-015EVALUATIONS OF MURINE MELANOMA MODELS BY TISSUE HISTOLOGY AND FT- RAMAN SPECTROSCOP. C. A. Dehelean (1), S. Ganta (2), S. Cîntă-Pînzaru (3), A. Fălămaş (3), S. A. Ciurlea (1), E. Alexa (4), M. Amiji (2). (1) University of Medicine and Pharmacy Victor Babes Timisoara, Timisoara, Romania;(2) Northeastern University Boston/School of Pharmacy, Boston, United States;(3) University Babes-Bolyai, Cluj-Napoca, Romania;(4) University of Agricultural Sciences and Veterinary Medicine of Banat, Timisoara, Romania

P203-016ROLE OF PARP-1 ON B(A)P INDUCED DNA METHYLATION VARIATION IN HUMAN BRONCHIAL EPITHELIAL CELLS. Z. X. Zhuang, G. H. Tao, C. M. Gong, L. Q. Yang, H. Y. Huang, J. J. Liu. Shenzhen Center for Disease Control and Prevention, Shenzhen, China

P203-017TRANSCRIPTOME ANALYSIS IDENTIFIES THE CARCINOGENIC EFFECTS OF ARISTOLOCHIC ACID IN RAT KIDNEY. T. Chen, Z. Li, Z. Su, L. Shi. US Food and Drug Administration / National Center for Toxicological Research, Jefferson, United States

P203-018PREDICTION OF CARCINOGENICITY IN VITRO BASED ON GENOTOXICITY AND TOXICOGENOMIC DATA. Y. Sheen (1), E. Yoon (1), J. Son (1), C. Keum (2), K. No (2). (1) Ewha Womans University, Seoul, Korea, Republic of;(2) Yonsei University,

P203-019A NOVEL MECHANISM ON MODULATION OF APE1 ACTIVITY VIA PROTEIN-PROTEIN INTERACTIONS OF GADD45A AND PCNA. H. L. Kim (1), S. U. Kim (2), Y. R. Seo (3). (1) Department of pharmacology, Institute for Basic Medical Science (IBMS), School of Medicine, Kyung Hee University, Seoul, Korea, Republic of;(2) Department of Life Science, School of Interdisciplinary Bioscience and Bioengineering, ;(3) Department of Pharmacology, School of Medicine, Kyung Hee University

P203-020IDENTIFICATION OF IONIZING RADIATION (IR) RESPONSIVE MRNA IN P53-DEFICIENT HUMAN NON-SMALL LUNG CANCER (NSCLC) GROWN IN THREE-DIMENSIONAL CELL CULTURE SYSTEM. J. Y. Kwon (1), J. S. Kim (2), Y. R. Seo (1). (1) Department of Pharmacology, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea, Seoul, Korea, Republic of;(2) Department of Biochemistry, Chonbuk National University Medical School, Jeonju, Republic of Korea,

P203-021ROLE OF AMBLYOMIN-X ON ANGIOGENESIS AND ENDOTHELIAL CELL PROLIFERATION. C. C. Drewes (1), R. Y. S. Dias (1), C. B. Hebeda (1), S. M. Simons (2), A. M. Chudzinski-Tavassi (2), S. H. P. Farsky (1). (1) University of São Paulo, São Paulo, Brazil;(2) Institute Butantan,

P203-022ROLE OF AMBLYOMIN-X ON MICROCIRCULATORY VESSELS, ENDOTHELIAL CELL MIGRATION AND TUMOR GROWTH. R. Dias (1), C. Drewes (1), C. Hebeda (1), S. Simons (2), A. M. Chudzinski-Tavassi (2), S. Farsky (1). (1) Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil;(2)

Laboratory of Biochemistry; Institute Butantan,

P203-023EFFECTS OF THE ENVIRONMENTAL PESTICIDE DDT AND ITS METABOLITES ON THE HUMAN BREAST CANCER CELL LINE MCF-7. D. Pestana (1), D. Teixeira (1), A. Faria (2), V. Domingues (3), R. Monteiro (1), C. Calhau (1). (1) Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, Porto, Portugal;(2) Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto and Chemistry Investigation Centre (CIQ), Faculty of Sciences, University of Porto, Portugal;(3) Requimte - Instituto Superior de Engenharia, Instituto Politécnico do Porto, Portugal

P203-024INCREASED BREAST CANCER RISK IN WOMEN WITH ENVIRONMENTAL EXPOSURE TO PESTICIDES. T. Parron (1), R. Alarcon (2), M. D. M. Requena (1), A. Hernandez (3).(1) Delegacion Provincial de Salud de Almeria, Almeria, Spain;(2) Universidad de Almeria, (3) Universidad de Granada,

P203-025A LIVER CANCER STUDY COMPARING TWO GEOGRAPHICAL AREAS WITH DIFFERENT LEVELS OF PESTICIDE USE. T. Parron (1), R. Alarcon (2), M. D. M. Requena (1), A. Hernandez (3), A. Pla (3). (1) Delegacion Provincial de Salud de Almeria, Almeria, Spain;(2) Universidad de Almeria ;(3) Universidad de Granada,

P203-026ESTABLISHMENT OF TWO-STAGE SKIN CARCINOGENICITY STUDY IN CB6F1 TG RASH2 MICE. K. Urano (1), M. Yasuda (1), H. Tsutsumi (1), M. Kawabe (2), M. Suguro (2), T. Numano (2), F. Furukawa (2). (1) Central Institute for Experimental Animals, Kawasaki, Japan;(2) DIMS Institute of Medical Science, Inc.,

P203-027IN VITRO SCREENING FOR THE CARCINOGENICITY OF EIGHT ORIENTAL HERBAL MEDICINES. H. Kam, H. J. Kang, S. H. Kim, M. O. Lee. Seoul National University, Seoul, Korea, Republic of

BARCELONAIUTOX 2010


63

P203-028ABERRANT PROMOTER METHYLATION OF RASSF1A, P16, DAPK, AND MEALLOTHIONEIN-IA IN HUMAN LUNG EXPOSED TO METALS AND CIGARETTE SMOKE CONDENSATE (CSC). H. Hamed, R. Gherbal, A. Torky, H. Foth. Institute of Environmental Toxicology, Martin Luther University, Halle/Saale, Germany

P203-029METHYLATION - UNMETHYLATION RESPONSE OF THE PROMOTER OF DNA REPAIR GENE POLY (ADP-RIBOSE) POLYMERASES (PARP1) TO INFLAMMATORY MEDIATORS AND ANTI-INFLAMMATORY DRUGS IN HUMAN LUNG. R. Gherbal, H. Hamed, B. Sacher, A. Torky, H. Foth. Institute of Environmental Toxicology, Halle/Saale, Germany

P203-030CHANGES OF THE GENOME DNA METHYLATION IN THE PROGRESS OF BENZO[A]PYRENE-INDUCED TRANSFORMATION. L. Yang, G. Tao, C. Gong, L. Zhou, J. Liu, Z. Zhuang. ShenZhen Center for Disease Control and Prevention, ShenZhen, China

P203-031DIETHYL PHTHALATE (DEP) ALTERS CELL CYCLE IN THE HUMAN MAMMARY EPITHELIAL MCF-7 CELL LINE. J. Navarro Yepes, R. Ruíz Ramos, M. E. Cebrián García. Centro de Investigación y de Estudios Avanzados del I.P.N (CINVESTAV), Ciudad de México, Mexico

P203-032ARSENIC INDUCES S100A4 AND S100A7 OVEREXPRESSION IN MCF-7 CELLS. A. Rios-Perez, R. Ruiz-Ramos, M. E. Cebrián. CINVESTAV-IPN, Mexico City, Mexico

P203-033EFFECTS OF SODIUM ARSENITE ON THE PI3K/AKT SIGNALING PATHWAY, PTEN AND PROLIFERATION IN MCF-7 MAMMARY EPITHELIAL CELLS. M. Esquivel, R. Ruiz-Ramos, M. E. Cebrián García. CINVESTAV-IPN, Mexico City, Mexico

P203-035PREVENTION OF OXIDATIVE STRESS AND ALTERATION IN HEPATIC AND TESTICULAR MRNA EXPRESSION GENES DURING AFLATOXICOSIS. S. H. Abdel-Azim, M. A. Abdel-Wahhab. National Research Center, Cairo, Egypt

P203-038THE COFFEE DITERPENE KAHWEOL INHIBITS INVASION AND ANGIOGENESIS VIA MODULATION OF STAT3 ACTIVATION. H. G. Kim, H. G. Jeong. Chungnam National University, Daejeon, Korea, Republic of

P203-042DIFFERENTIAL EFFECT OF CASIOPEINAS IN NEUROBLASTOMA CELL LINES. P. M. Monroy-Romo (1), T. Garcia-Gasca (2), L. Ruiz-Azuara (3), M. E. Bravo-Gómez (3), C. Mejia

(4), R. Ferriz Martínez (1). (1) Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México y Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, México, D.F., Mexico;(2) Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro, Mexico;(3) Facultad de Química, Universidad Nacional Autónoma de México, Mexico,D.F., Mexico;(4) Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, D.F., Mexico

P203-044MECHANISMS OF INHIBITION OF GAP JUNCTIONAL INTERCELLULAR COMMUNICATION BY POTENTIAL TUMOR PROMOTERS. M. Odabasi (1), A. Wilke (2), H. Boke

(2), L. Keinow (2), E. Kumar (2), J. E. Trosko (2), B. Upham (2). (1) Ankara University, Institute of Forensic Medicine, Ankara, Turkey;(2) Department of Pediatrics & Human Development, and the National Food Safety & Toxicology Center, Michigan State University,

P203-045ENVIRONMENTAL EXPOSURE TO PESTICIDES MAY ENHANCE THE RISK OF BLADDER CANCER. T. Parron (1), R. Alarcon (2), M. D. M. Requena (1), A. Hernandez (3), A. Pla (3). (1) Delegacion Provincial De Salud De Almeria, Spain (2) Universidad De Almeria, Spain (3) Universidad De Granada, Spain

P203-046DIFFERENTIAL ROLES OF CYTOCHROMES P4501A1 AND 1A2 IN LUNG CARCINOGENESIS MEDIATED BY POLYCYCLIC AROMATIC HYDROCARBONS (PAHS) IN MICE: IMPLICATIONS FOR LUNG CANCER IN HUMANS. B. Moorthy, L. Wang, W. Jiang. Baylor College of Medicine, Houston, United States

P203-051PEER REVIEW AND PWG: SCIENTIFIC SOLUTION FOR CONFLICTING PATHOLOGICAL DATASETS. S. Gröters, C. Wiemann, W. Kaufmann. BASF SE, Ludwigshafen, Germany

P204: REPRODUCTION AND DEVELOPMENT

P204-001DETERMINING THE OPTIMAL TERATOGENIC DOSAGE OF ASPIRIN IN SPRAGUE DAWLEY RATS. M. Zhao. Toxicology Institute, Centre for Disease Prevention and Control of Guangdong Province,, Guangzhou, China

P204-002DEVELOPMENTAL TOXICOLOGY OF MONOCROTALINE: PHYSICAL AND NEUROBEHAVIORAL EVALUATION IN RAT OFFSPRING. E. L. Ricci, C. S. Telloli, D. P. Dalmolin, M. M. Bernardi, S. L. Góniak, H. S. Spinosa. São Paulo of University, Osasco, Brazil

P204-003EMBRYOPROTECTIVE ROLE OF CONSTITUTIVE ANTIOXIDATIVE CATALASE IN WILD-TYPE AND ACATALASEMIC MICE IN VIVO AND IN EMBRYO CULTURE. J. Perstin, P. G. Wells. University of Toronto, Toronto, Canada

P204-004MORPHOLOGIC AND MORPHOMETRIC CHANGES IN OVARY DUE TO CHRONIC USE OF METHYLPHENIDATE IN PREADOLESCENT FEMALE MICE. S. Fazelipour. Tehran Medical Branch, Islamic Azad University, Tehran, Iran (Islamic Republic of)

P204-005EMBRYOTOXIC AND TERATOGENIC EFFECTS OF ROUNDUP® MAX ON RAT DEVELOPMENT. A. Gerişlioğlu (1), C. Güngörmüş (1), A. Korkmaz (2), D. Kolankaya (1). (1) Hacettepe University, Ankara, Turkey;(2) Ministry of Agriculture and Rural Affairs, Ankara, Turkey

P204-006REPRODUCTIVE TOXICITY OF NIGERIAN BONNY LIGHT CRUDE OIL UPON WITHDRAWAL OF TREATMENT IN MALE RATS. I. A. Adedara, T. Ehwerhemuepha, R. Teberen, A. P. Ebokaiwe, E. O. Farombi. University of Ibadan, Nigeria, Ibadan, Nigeria


64

P204-007MDMA (ECSTASY) DELAYS PUBERTAL DEVELOPMENT AND ALTERS SPERM QUALITY AFTER DEVELOPMENTAL EXPOSURE IN THE RAT. M. Barenys (1), L. Camps

(2), E. Teixido (1), J. De Lapuente (2), J. Gomez-Catalan (1), J. Gonzalez-Linares (2), J. Serret (2), M. Borras (2), M. Rodamilans (1), J. M. Llobet (1). (1) Gret-Ceretox. Universitat De Barcelona Barcelona, Spain, (2) Gret-Ceretox. Barcelona Science Park. Barcelona, Spain

P204-008REPRODUCTIVE EFFECTS OF TWO CRUDE OILS IN MALE GUINEA PIG. O. Afonne (1), O. Orisakwe (2), I. Onyiaorah (2). (1) Indian Institute of Toxicology Research, Lucknow, Lucknow, India;(2) Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nnewi, Nigeria

P204-009HISTOLOGICAL EXAMINATION OF THE PLACENTA OF MICE FOLLOWING PHENOL ADMINISTRATION. Z. Tootian. Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran (Islamic Republic of)

P204-010THE EFFECTS OF IPOMOEA CARNEA ON NEONATE BEHAVIOR: A STUDY IN GOATS. S. Górniak (1), A. Gotardo (1), J. Pfister (2). (1) School of Veterinary Medicine - University of São Paulo, São Paulo, Brazil;(2) USDA-ARS Poisonous Plant Research Laboratory, Brazil

P204-011DI (2-ETHYLHEXYL) PHTHALATE MAY CAUSE REPRODUCTIVE AND DEVELOPMENTAL TOXICITY THROUGH PPARALPHA. Y. Hayashi (1), Y. Ito (2), Y. Yanagiba (1), D. Wang (1), N. Yamagishi (1), H. Tamada (1), H. Naito (1), T. Nakajima (1). (1) Nagoya University Graduate School of Medicine, Nagoya, Japan;(2) Nagoya city University Graduate School of Medical Sciences,

P204-012EFFECTS OF THE PYRIDOINDOLE SME1EC2 ON NEUROBEHAVIORAL DEVELOPMENT IN RATS: DEVELOPMENTAL NEUROTOXICITY STUDY. M. Mach (1), E. Ujhazy

(2), J. Navarova (2), V. Ponechalova (2), V. Snirc (2), M. Dubovicky (2). (1) Institute of Experimental Pharmacology & Toxicology, SASc., Bratislava, Slovakia (Slovak Republic);(2) Institute of Experimental Pharmacology & Toxicology,

P204-013COMPARATIVE EFFECTS OF METHAMIDOPHOS TECHNICAL AND COMMERCIAL GRADE ON SPERM QUALITY AND OXIDATIVE DAMAGE IN MICE SPERMATOZOA. M. Urióstegui-Acosta (1), M. D. J. Solis-Heredia (1), V. M. Pérez- Monroy (2), J. A. Hernández-Alcántara (2), B. Quintanilla-Vega (1). (1) Centro de Investigación y de Estudios Avanzados del I.P.N., México, Mexico;(2) Unidad Profesional Interdisciplinaria de Biotecnología del I.P.N., México, Mexico

P204-014DEVELOPMENTAL TOXICITY OF COPAIBA OIL-RESIN (COPAIFERA RETICULATA) IN RATS. C. G. Sachetti, M. L. Fascineli, E. D. Caldas. Universidade de Brasília, Brasília, Brazil

P204-015PROTECTIVE EFFECT OF RESVERATROL ON SPERM OXIDATIVE DAMAGE CAUSED BY METHYL-PARATHION EXPOSURE IN MICE. C. Vega-García (1), M. D. J. Solís-Heredia (2), G. Chamorro-Cevallos (1), V. M. Monroy-Pérez (3), J. A. Hernández-Alcántara (3), B. Quintanilla-Vega (2). (1) Escuela Nacional de Ciencias Biologicas, ENCB-IPN, México, D.F., Mexico;(2) CINVESTAV-IPN, México, D.F., Mexico;(3) Unidad Profesional Interdisciplinaria de Biotecnología UPIBI-IPN,

P204-016ULTRASONIC VOCALIZATIONS (USV) IN RAT PUPS, AN ANIMAL FRIENDLY MARKER TO TEST DEVELOPMENTAL NEUROTOXICITY. D. De Groot (1), J. Swierstra (1), L. Blauw (1), L. Damsteegt (1), L. Van Der Horst (1), M. Otto (1), R. Bulthuis (2), H. Van Der Wiel (3), C. Rubingh (1). (1) TNO Quality of Life, Zeist, NL, Zeist, Netherlands;(2) Metris BV, Hoofdorp, NL, Netherlands;(3) TNO Defence, Security and Safety, Rijswijk, NL, Netherlands

P204-017EFFECT OF A BLUE-GREEN ALGAL TOXIN, CYLINDROSPERMOPSIN (CYN), ON HUMAN LUTEINIZED GRANULOSA CELL (GC) PROTEIN SYNTHESIS IN VITRO. F. Young (1), D. Zebian (1), S. Froscio (2), A. Humpage (2). (1) Flinders University of South Australia, Adelaide, Australia;(2) Australian Water Quality Centre, SA Water, Adelaide, Australia

P204-018ESTABLISHMENT OF TRANSGENIC MOUSE MODEL EXPOSED TO EXCESSIVE ESTROGENS IN THE FETAL PERIOD. T. Nakanishi, I. Yoshida, H. Nagase. Gifu Pharmaceutical University, Gifu, Japan

P204-019ASSESSMENT OF MALE REPRODUCTIVE TOXICITY PARAMETERS IN CYNOMOLGUS MONKEYS. A. Faqi, C. Diabo, C. Sharma, M. Kob, B. Lewis, C. Cohle, S. Magness. MPI Research, Mattawan, United States

P204-020POST-TRANSCRIPTIONAL EFFECT OF ENDOCRINE DISRUPTORS IN MOUSE TESTICULAR SERTOLI CELLS. S. Y. Hwang (1), S. J. Kim (1), H. W. Park (1), Y. R. An (1), H. Cho (1), M. J. Oh (2), J. H. Oh (3), S. J. Yoon (3). (1) Hanyang University, Ansan, Korea, Republic of;(2) GenoCheck Co. Ltd., ;(3) Korea Institute of Toxicology,

P204-021REVIEW OF REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF MANUFACTURED NANOMATERIALS. M. Ema, N. Kobayashi, M. Naya, S. Hanai, J. Nakanishi. National Institute of Advanced Science and Technology (AIST), Tsukuba, Japan

P204-022SILENCING OF NEUROPATHY TARGET ESTERASE (NTE) MODIFIES GENE EXPRESSION DURING FIRST STAGES OF DIFFERENTIATION. D. Pamies, C. Estevan, A. C. Romero, E. Vilanova, M. A. Sogorb. Instituto de Bioingeniería, Elche, Spain

P204-023THE STUDY OF INSECTICIDE CARBOFURAN EXPOSURE ON REPRODUCTIVE SYSTEM OF JUVENILE WISTAR RATS. L. Ivanova. L.I.Medved’s, Institute Of Ecohygiene And Toxicology, КYIV, Ukraine

P204-024EFFECTS ON THE RETINOID SYSTEM AND OTHER ENDPOINTS IN RAT OFFSPRING AND DAMS FOLLOWING IN UTERO AND LACTATIONAL EXPOSURE TO A CHEMICAL MIXTURE PRESENT IN THE ARCTIC INUIT POPULATION. J. Esteban (1), L. Elabbas (2), B. Daniel (2), N. Giese (3), G. Hamscher (3), H. Nau (3), W. J. Bowers (4), I. Chu (4), A. Åkesson (2), H. Håkansson (2). (1) Instituto de Bioingeniería, Universidad Miguel Hernández, Elche (Alicante), Spain / Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Elche, Spain;(2) Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ;(3) Institute for Food Toxicology and Analytical Chemistry, University of Veterinary Medicine, Hannover, Germany, ;(4) Neurotoxicology Laboratory, Environmental Health Sciences and Research Bureau, Health Canada, Ottawa, Canada,

BARCELONAIUTOX 2010


65

P204-025DELAYED PREPUTIAL SEPARATION IN RATS DOES NOT NECESSARILY INDICATE ANTIANDROGENICITY - EVALUATION OF 2-GENERATION TOXICITY STUDIES OF CHEMICALS AND AGRO-CHEMICALS. S. Melching-Kollmuss, K. Hempel, R. Buesen, I. Fegert, S. Schneider, B. Van Ravenzwaay. BASF SE, Ludwigshafen, Germany

P204-026MATERNAL AND DEVELOPMENTAL TOXICITY STUDY OF TETRODOTOXIN IN RATS. A. Guzmán (1), A. Ho (2), P. Ruth (3), A. Tortajada (1), A. R. Fernández De Henestrosaa (1), P. Thirlwell (3), C. García (1), M. T. Ruiz (1), A. P. Marín (1). (1) Esteve, Barcelona, Spain;(2) WEX Pharmaceuticals Inc, Vancouver, Cayman Islands;(3) Huntingdon Life Sciences, Huntingdon, United Kingdom

P204-027INFLUENCE OF AGE ON SUB-CHRONIC TOXICITY OF AQUEOUS LEAVES EXTRACT OF CALOTROPIS PROCERA IN RABBITS. G. B. Pouokam (1), D. Christianna Joshua

(2), A. Hatem Abdel Moniem (3), A. Aliyu (4), P. Okewole (5). (1) Department of Biochemistry,University of Yaoundé 1-Cameroon, Yaoundé, Cameroon;(2) Toxicology Unit,National Veterinary Research Institute,Vom-Nigeria, ;(3) Chemical laboratory,Medicolegal Department,Ministry of Justice-Egypt, ;(4) Biochemistry Division,National Veterinary Research Institute,Vom-Nigeria, ;(5) Center Diagnosis,National Veterinary Research Institute,Vom-Nigeria,

P204-030TOXIC EFFFECTS OF U&DEE SWEET BITTER HERBAL SUPPLEMENT ON THE ACCESSORY SEX ORGANS OF MALE WISTAR RATS.. E. Obi, R. Negedu-Momo, O. Obioma, J. Afonne, O. E. Orisakwe. NNAMDI AZIKIWE UNIVERSITY, NNEWI, Nigeria

P204-033RELATIONSHIP BETWEEN URINARY PHYTOESTROGEN LEVELS AND SEMEN QUALITY IN HUMANS. Y. Xia, P. Zhu, M. Chen, C. Lu, S. Wang, X. Wang. Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China

P204-039RISK OF CRYPTORCHIDISM IN GEOGRAPHIC AREAS WITH HIGH USE OF PESTICIDES. T. Parron (1), F. Cavieres (2), R. Alarcon (3), M. D. M. Requena (1), A. Hernandez (4). (1)

Delegacion Provincial de Salud de Almeria, Almeria, Spain;(2) Universidad de Valparaiso, ;(3) Universidad de Almeria, ;(4) Universidad de Granada,

P205: INMUNOTOXICITY

P205-001INVESTIGATION IMMUNOMODULATORY EFFECT OF ANTICOAGULANT WARFARIN BY EXPERIMENTAL CAUSED CONTACT HYPERSENSITIVITY REACTIO. V. Radovic. STADA Hemofarm AD, Belgrade, Serbia

P205-002MECHANISM OF CARBAMATE PESTICIDE-INDUCED INHIBITION OF HUMAN NK ACTIVITY. Q. Li, M. Kobayashi, T. Kawada. Nippon Medical School, Tokyo, Japan

P205-003THE DUAL EFFECT OF MYCOTOXINS ON THE IMMUNE RESPONSE IN INFECTIOUS BURSAL DISEASE(IBD) VACCINATED CHICKENS. H. El Miniawy, M. Samy Ahmed, K. Abd El Aziz. Faculty of Veterinary Medicine, Gyza, Egypt, Giza, Egypt

P205-004SYNERGISTIC IMMUNOSUPPRESSION OF T-DEPENDENT ANTIBODY RESPONSES BY POLYCYCLIC AROMATIC HYDROCARBONS AND ARSENIC IN C57BL/6J MICE SPLEEN CELLS. S. Burchiel, Q. Li, F. Lauer, L. Hudson, K. J. Liu. The University of New Mexico, Albuquerque, United States

P205-005APPLYING PROTEOMICS IN A MOUSE MODEL OF CHEMICAL-INDUCED ASTHMA. S. Haenen (1), J. Vanoirbeek (1), V. De Vooght (1), E. Clynen (2), L. Schoofs (1), B. Nemery (1), P. Hoet (1). (1) K.U.Leuven, Leuven, Belgium;(2) Hasselt University,

P205-006TOLL-LIKE RECEPTOR 4-DEPENDENT UPREGULATION OF HEME OXYGENASE-1 AND ANTI-INFLAMMATORY CYTOKINES IN MOUSE LUNG FOLLOWING LOW-LEVEL TOLUENE EXPOSURE. H. Fujimaki (1), T. T. Win-Shwe (1), Y. Yoshida (2), N. Kunugita (3), K. Arashidani (2). (1) National Institute for Environmental Studies, Tsukuba, Japan;(2)

University of Occupational and Environmental Health, Japan ;(3) National Institute of Public Health,

P205-007DEVELOPMENTAL TOLUENE EXPOSURE ALTERS NEUROIMMUNE MARKERS IN THE HIPPOCAMPUS OF INFANT MICE. T. T. Win Shwe (1), N. Kunugita (2), Y. Yoshida

(3), K. Arashidani (3), H. Fujimaki (1). (1) National Institute for Environmental Studies, Tsukuba, Japan;(2) National Institute of Public Health, (3) University of Occupational and Environmental Health, Japan,

P205-0082,3,7,8-TETRACHLORODIBENZO-P-DIOXIN ANTICIPATES THE ACTIVATION OF NF-KB DURING BOVINE HERPESVIRUS 1 INFECTION. F. Fiorito (1), R. Ciarcia (2), G. E. Granato (1), E. De Blasio (1), G. Marfè (3), V. Iovane (1), L. De Martino (1), S. Florio (2), U. Pagnini (1). (1) Department of Pathology and Animal Health -University of Naples “Federico II”, Naples, Naples, Italy;(2) Department of Structures, Function and Biological Technologies - University of Naples “Federico II”, Naples;(3) Department of Experimental Medicine and Biochemical Sciences, University of Rome “Tor Vergata”, Rome,

P205-0092,3,7,8-TETRACHLORODIBENZO-P-DIOXIN INCREASES SIRT3 PROTEIN LEVELS DURING BOVINE HERPESVIRUS 1 INFECTION. F. Fiorito (1), G. Marfè (2), R. Ciarcia (3), G. E. Granato (1), E. De Blasio (1), G. Iovane (4), S. Florio (3), L. De Martino (1). (1) Department Of Pathology And Animal Health - University Of Naples “Federico II”, Naples (Italy), (2) Department Of Experimental Medicine And Biochemical Sciences, University Of Rome “Tor Vergata”, Rome (Italy), (3) Department Of Structures, Function And Biological Technologies - University Of Naples “Federico II”, Naples (Italy), (4) Experimental Zooprophylactic Institute Of Southern Italy – Portici, Naples (Italy).

P205-010KEYHOLE LIMPET HEMOCYANIN (KLH) ADMINISTERED BY THE SUBCUTANEOUS OR INTRAVENOUS ROUTE DOES NOT INDUCE ANY SIGNIFICANT CHANGES IN THE RAT HEMOLYMPHOPOIETIC SYSTEM. R. Fleurance (1), A. Nguyen (1), C. Mimouni (1), J. J. Legrand (1), J. Descotes (2). (1) CIT Safety and Health Research Laboratories, France, Evreux, France;(2) Lyon Poison Center, France,

P205-011INDUCTION OF INTERLEUKIN-8 (IL8), HEME OXYGENASE 1 (HMOX) AND PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PROTEIN 1 (PMAIP1) EXPRESSION IN HUMAN THP-1 MONOCYTES AS POTENTIAL MARKERS OF THE SKIN SENSITIZING POTENTIAL OF CHEMICALS. J. Arkusz (1), M. Stępnik (1), J. Dastych (2). (1) Nofer Institute of Occupational Medicine, Lodz, Poland;(2) Institute for Medical Biology, Polish Academy of Sciences, Lodz, Poland


66

P205-012Á-LIPOIC ACID ATTENUATES THE DEVELOPMENT OF DNFB-INDUCED ATOPIC DERMATITIS-LIKE SYMPTOMS IN NC/NGA MICE. K. Gun-Dong, K. Tae-Ho, J. An-Hee, P. Cheung-Seog. Kyung Hee University, Seoul, Korea, Republic of

P205-013ACROLEIN SUPPRESSES LPS-INDUCED INFLAMMATORY CYTOKINE PRODUCTION AND MATURATION OF DENDRITIC CELLS VIA INHIBITS EXPRESSION OF SURFACE MOLECULES. T. H. Kim, G. D. Kim, A. H. Jang, C. S. Park. Kyung Hee University, Seoul, Korea, Republic of

P205-014ADMINISTRATION OF ROSMARINIC ACID AMELIORATED DNFB-INDUCED ATOPIC DERMATITIS LIKE SYMTOMS IN NC/NGA MICE. A. H. Jang, T. H. Kim, G. D. Kim, C. S. Park. Kyung Hee University, seoul, Korea, Republic of

P205-015APPLYING PROTEOMICS TO IDENTIFY CANDIDATE BIOMARKERS FOR THE IMMUNOMODULATORY MYCOTOXIN DEOXYNIVALENOL (DON) AND THE CARCINOGEN 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE (PHIP). A. Nogueira Da Costa (1), R. S. Mijal (1), J. N. Keen (2), S. B. Stølevik (3), U. C. Nygaard (3), E. (1) Molecular Epidemiology Unit, University of Leeds, Leeds, United Kingdom;(2) Research Institute of Membrane and Systems Biology, University of Leeds ;(3) Division of Environmental Medicine, Norwegian Institute of Public Health, Norway ;(4) International Agency for Research on Cancer,

P205-016DOES ZEARALENONE, AN ESTROGENIC MYCOTOXIN, HAVE IMMUNOTOXIC EFFECTS?. I. M. Hueza (1), J. C. Benassi (2), A. O. Latorre (2), L. E. Raspantini (2), P. C. Raspantini (2), S. L. Górniak (2). (1) School of Pharmacy and Biochemistry/Federal University of São Paulo, São Paulo, Brazil;(2) School of Veterinary Medicine and Animal Science/ University of São Paulo,

P205-017RAPHANUS SATIVUS EXTRACT PREVENTS BALAB/C MICE AGAINST IMMUNOTOXICITY OF ZEARALENONE: HIGH SUBCHRONIC DOSING STUDY. J. Ben Salah-Abbès (1), S. Abbès (1), M. A Abdel-Wahhab (2), R. Oueslati (1). (1) Laboratory Of Immunology, Environmental Microbiology And Cancerology, Faculty Of Sciences Bizerte, Tunisia., (2) Food Toxicology & Contaminants Dept. National Research Centre, Dokki, Cairo, Egypt..

P205-018INDUCTION OF HEAT-SHOCK PROTEIN 70 BY CROTONALDEHYDE IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS. D. S. Ryu, S. E. Lee, S. I. Jeong, Y. S. Park. Department of Microbiology, College of Medicine, Kyung Hee University, seoul, Korea, Republic of

P205-01928-DAY DIETARY EXPOSURE OF MICE TO A LOW TOTAL DOSE (7 MG/KG) OF PERFLUOROOCTANESULFONATE (PFOS) ALTERS NEITHER THE CELLULAR COMPOSITIONS OF THE THYMUS AND SPLEEN NOR HUMORAL IMMUNE RESPONSES: DOES THE ROUTE OF ADMINISTRATION PLAY A PIVOTAL ROLE IN PFOS-I. M. R. Qazi, B. D. Nelson, J. Depierre, A. V. Manuchehr. Stockholm University, Stockholm, Sweden

P205-020ALPHA-LIPOIC ACID ATTENUATES THE DEVELOPMENT OF DNFB-INDUCED ATOPIC DERMATITIS-LIKE SYMPTOMS IN NC/NGA MICE. G. D. Kim, T. H. Kim, A. H. Jang, C. S. Park. Kyung Hee University, Seoul, Korea, Republic of

P205-021ROLE OF LEWIS X SUGARS IN THE DIFFERENTIAL ALLERGENICITY OF WILD TYPE AND RECOMBINANT LACTOFERRIN. R. Dearman, R. Almond, I. Kimber. University of Manchester, Manchester, United Kingdom

P205-022ALLERGEN-STIMULATED EXPRESSION OF INTERLEUKIN (IL)-17 ISOFORMS IN MICE. I. Kimber, M. Hayes, R. Dearman. University of Manchester, Manchester, United Kingdom

P205-023TOXIC EFFECTS OF SENECIO BRASILIENSIS ON RAT PHAGOCYTES. F. Elias (1), I. Hueza (2), A. Latorre (1), S. Gorniak (1). University of Manchester, Manchester, United Kingdom

P205-024INFLAMMATORY RESPONSE TO ORTHOPAEDIC COBALT CHROMIUM ALLOY WEAR DEBRIS IN A RODENT AIR POUCH MODEL. M. Akbar (1), M. H. Grant (1), J. Brewer (2). (1) University of Strathclyde, Glasgow, United Kingdom;(2) University of Glasgow, Glasgow, United Kingdom P205-025IPOMOEA CARNEA, A POISONOUS PLANT, PROMOTES CHANGES IN LYMPHOCYTE DISTRIBUTION OF YOUNG RATS. F. Pípole (1), A. O. Latorre (1), I. M. Hueza (2). (1) School Of Veterinary Medicine And Animal Science, University Of São Paulo, Brazil (2) School Of Pharmacy And Biochemistry, Federal University Of São Paulo. Brazil

P205-026INFLUENCES OF INORGANIC LEAD (PB) ON ANXIETY-LIKE BEHAVIOR AND STRESS RESPONSES IN MICE. D. Kim. Korean Air Force Academy, Cheongwon, Korea, Republic of

P205-027EFFECTS OF IRREVERSIBLE ACETYLCHOLINESTERASE INHIBITION BY ISOPROPYL METHYLPHOSPHONOFLUORIDATE ON TH1/TH2 RESPONCE. R. Zdanowski, M. Paluch, J. Bany, M. Kowalczyk. Military Institute of Hygiene & Epidemiology, Warsaw, Poland

P205-028EVALUATION OF CYTOKINE PRODUCTION IN AURICULAR LYMPH NODES AS AN ENDPOINT DURING MURINE CONTACT ALLERGY. A. Karakaya, O. C. Ulker. Ankara University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey

P205-029EFFECTS OF AFLATOXIN M1 AND AFLATOXIN M2 ON J774A.1 MURINE MACROPHAGE CELL LINE. R. Russo (1), G. Bianco (2), S. Marzocco (2), A. De Simone (1), G. Autore

(2), L. Severino (1). (1) University of Naples Federico II, Castellammare di Stabia, Italy; (2) University of Salerno, Italy

P205-030CO-EXPOSURE TO MERCURY ACCELERATES AUTOIMMUNITY INDUCED BY TRICHLOROETHYLENE. K. Gilbert (1), B. Rowley (2), L. Hennings (3), S. Blossom (1). (1) Arkansas Children’s Hospital Research Institute, Little Rock, United States;(2) University of Central Arkansas;(3) University of Arkansas for Medical Sciences,

BARCELONAIUTOX 2010


67

P205-031INDUCTION OF MAST CELL DEGRANULATION BY TRITERPENOIDAL SAPONINS ISOLATED FROM CIMICIFUGA RHIZOME. M. S. Dong (1), J. Y. Choi (1), S. J. Jeon (2), Y. I. Park (1), K. H. Son (2). (1) Korea university, Seoul, Korea, Republic of;(2) Andong National University,

P205-032IMMUNOTOXIC EFFECTS OF MERCURY COMPOUNDS IN HUMANS: CONCORDANCE OF IN VITRO AND IN VIVO STUDIES. E. Silbergel (1), R. Gardner (2), J. M. De Souza

(2), A. M. Ventura (2), J. Nyland (2). (1) Johns Hopkins School of Public Health, Baltimore, United States;(2) Stockhold, Sweden

P205-033QUERCETIN AND CATECHIN ATTENUATE CHLORPYRIFOS-INDUCED APOPTOSIS IN MURINE THYMOCYTES. A. Prakash (1), S. Khan (2), M. Aggarwal (2), A. Telang (2), J. Malik (2). (1) Pt. Deen Dayal Upadhyay Veterinary and Animal Science University (DUVASU), Mathura, India;(2) Indian Veterinary Research Institute, Bareilly, India

P205-034MECHANISM OF T CELL PROGRAMMING BY TRICHLOROETHYLENE. S. Blossom, K. Gilbert, H. Gomez-Acevedo, N. Ashley. Arkansas Children’s Hospital Research Institute, Little Rock, United States

P205-035QUERCETIN AND CATECHIN ATTENUATE CHLORPYRIFOS-INDUCED APOPTOSIS IN MURINE THYMOCYTES. A. Prakash (1), S. Khan (1), M. Aggarwal (2), A. Telang (1), J. Malik (1). (1) Indian Veterinary Research Institute, Izatnagar, India;(2) Leibniz Research Centre for Working Environment and Human Factors, Bernburg (Saale), Germany

P205-036CANNABIDIOL, A NONPSYCHOTROPIC PHYTOCANNABINOID, INDUCES APOPTOSIS IN CULTURED MURINE MICROGLIA. H. Y. Wu (1), C. Guaza (2), T. R. Jan (1). (1) Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan., Taipei, Taiwan;(2) Neuroimmunology Group, Functional and Systems Neurobiology Department, Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain,

P205-037MARMOSET MONKEYS AS PRECLINICAL MODELS FOR RESPIRATORY DISEASES. S. Seehase (1), H. D. Lauenstein (1), S. Switalla (1), F. Prenzler (1), F. J. Kaup (2), E. Fuchs (2), N. Krug (1), C. Schlumbohm (2), K. Sewald (1), A. Braun (1). (1) Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany;(2) German Primate Center

P205-039FUNCTIONAL DISORDER OF PRIMARY IMMUNITY RESPONDING TO RESPIRATORY SYNCYTIAL VIRUS INFECTION IN OFFSPRING MICE EXPOSED PERINATALLY TO DECABROMINATED DIPHENYL ETHER (DBDE). W. Watanabe (1), R. Sawamura (2), T. Shimizu (2), K. Konno (2), A. Hirose (3), M. Kurokawa (2). (1) School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Japan, Nobeoka, Japan;(2) School of Pharmaceutical Sciences, Kyushu University of Health and Welfare;(3) Biological Safety Research Center, National Institute of Health Sciences

P205-045INHALED HYDROQUINONE AFFECTS LEUKOCYTE RECRUITMENT INTO LUNG AND ADHESION MOLECULES EXPRESSION. A. L. T. Ribeiro, A. L. B. Shimada, C. B. Hebeda, W. Tavares De Lima, S. H. P. Farsky. University of Sao paulo, Sao Paulo, Brazil

P205-051GLUTARALDEHYDE BEING A CONTACT SENSITIZER IN THE LOCAL LYMPH NODE ASSAY? H. O. Ku (1), S. H. Jeong (1), H. G. Kang (1), S. W. Son (1), D. Y. Ryu (2). (1) National Veterinary Research and Quarantine Service, Anyang, Korea, Republic of;(2) College of Veterinary Medicine, Seoul National University, Seoul, Korea, Republic of

P206: TARGET ORGAN TOXICITY: HEPATOTOXICITY

P206-001BENEFICIAL EFFECT OF COMBINED ADMINISTRATION OF SOME NATURALLY OCCURRING ANTIOXIDANTS AND THIOL CHELATORS IN THE TREATMENT OF ACUTE MERCURY INTOXICATION. D. Joshi. School of studies in Zoology, Jiwaji University, Gwalior, India, Gwalior, India

P206-002ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITY OF POLYGONUM BISTORTA (LINN.) AND ITS ACTIVE PRINCIPLE AGAINST ACETAMINOPHEN-INDUCED LIVER TOXICITY IN MALE RATS. D. K. Mittal. School of Studies in Zoology, Jiwaji University, Gwalior (M.P.), India, Gwalior, India

P206-003NATURAL EXTRACTS FACING HEPATOCYTE INJURY IN VITRO: DOES INDUCIBLE NITRIC OXIDE INHIBITION DIFFER FROM THAT OF NON-SELECTIVE NITRIC OXIDE INHIBITION CONCERNING MODULATION OF THE PROTECTIVE OUTCOME?. N. El Sayed. German University in Cairo - GUC, cairo, Egypt

P206-004DETERMINATION OF CARBAMYL PHOSPHATE SYNTHETASE-1, GLUTAMINE SYNTHETASE AND ARGINASE ENZYME ACTIVITIES AS MARKERS OF ACETAMINOPHEN HEPATOTOXICITY IN RATS. H. Fouad Abd El Salam, N. Barghash, F. El-Sayed, M. Barakat. Faculty Of Medicine- Alexandria University, Egypt

P206-005INVESTIGATION OF STRUCTURE-ACTIVITY RELATIONSHIPS FOR MITOCHONDRIAL TOXICITY. L. Fisk (1), N. Greene (2), R. Naven (2), M. Patel (1). (1) Lhasa Limited, Leeds, United Kingdom;(2) Pfizer Inc, Groton, United States

P206-006PHYTOCHEMICAL INHIBITION OF RADICAL-INDUCED MITOCHONDRIAL INJURY BY AMPK-GSK3BETA PATHWAY. S. G. Kim. College of Pharmacy, Seoul National University, Seoul, Korea, Republic of

P206-007TOXICITY EVALUATION OF CASSIA FISTULA FRUITS ON LIVER AND KIDNEY IN MICE. H. Kalantari, M. T. Jalali, A. Salimi. Ahvaz Jondishapour University Of Medical Sciences Iran (Islamic Republic of)

P206-008EXPERIMENTAL STUDY ON BRAIN AND HEPATIC EFFECTS OF 7-NITROINDAZOLE – SELECTIVE NNOS INHIBITOR AFTER MULTIPLE ADMINISTRATION IN RATS. V. Vitcheva, R. Simeonova, M. Mitcheva. Faculty of Pharmacy - Sofia, Sofia, Bulgaria

P206-009EFFICACY OF SENNA OCCIDENTALIS IN THE AMELIORATION OF TETRACYCLINE INDUCED HEPATO- AND NEPHRO-TOXICITIES IN RABBITS. M. Abongwa (1), A. Gafer Rageh (2), O. Arowolo (3), C. Dawurung (4), O. Oladipo (4), A. Atiku (4), P. Okewole (4), D. Shamaki (4). (1) University of Buea, Cameroon, Buea, Cameroon;(2) Medicolegal Labs, Egypt ;(3)

University of Ibadan, Nigeria ;(4) National Veterinary Research Institute, Vom, Nigeria,


68

P206-010ANTIOXIDANT DEFENCES IN BROWN NORWAY RATS IN RESPONSE TO ACUTE DOSES OF DIAZINON. M. Hajigholamali (1), M. Jafari (1), R. Hajihossaini (2), M. Abasnezhad

(2), M. Salehi (2). (1) Department of Biochemistry-Applied Neurosciences Research Center, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran (Islamic Republic of);(2) ,

P206-011EFFECT OF MYOSMINE, COMPARED TO NICOTINE, ON CELL VIABILITY AND LDH LEAKAGE IN ISOLATED RAT HEPATOCYTES. M. Kondeva-Burdina (1), G. Gorneva (2), M. Mitcheva (1). (1) Faculty of Pharmacy, Medical University-Sofia, Sofia, Bulgaria;(2) Institute of Molecular Biology, Bulgarian Academy of Science,

P206-012THE EFFECT OF CHROMIUM (VI) ON THE REDOX HOMEOSTASIS AND THE ACTIVITY OF SELENOENZYMES THIOREDOXIN REDUCTASE AND GLUTATHIONE PEROXIDASE IN RAT LIVER AND KIDNEYS. A. Hodková, D. Kotyzová, V. Eybl. Faculty of Medicine in Pilsen, Charles University in Prague, Plzeň, Czech Republic

P206-013INHIBITORY EFFECTS OF THE ANTHOCYANIN FROM PURPLE-FLESHED SWEET POTATO ON DIMETHYLNITROSAMINE-INDUCED FIBROSIS OF THE LIVER IN RATS. H. G. Jeong (1), J. H. Choi (1), Y. P. Hwang (1), C. Y. Choi (2), Y. C. Chung (2). (1) Chungnam National University, Daejeon, Korea, Republic of;(2) Korea International University, Korea, Republic of

P206-014FUNCTIONAL PREDICTION ANALYSIS BASED ON GLOBAL GENE EXPRESSION BY USING NRF2 KNOCKOUT MOUSE LIVER EXPOSED TO TCDD. H. Sato (1), M. Matsumoto (1), K. Itoh (2), M. Yamamoto (3), Y. Aoki (1). (1) National Institute for Environmental Studies, Tsukuba, Japan;(2) Hirosaki University School of Medicine, Japan;(3) Tohku University School of Medicine,

P206-015AMIODARONE-INDUCED PHOSPHOLIPIDOSIS AND STEATOSIS IN HUMAN HEPATOMA HEPARG CELLS. S. Anthérieu, B. Fromenty, M. A. Robin, A. Guillouzo. INSERM U991 - Université de Rennes 1, RENNES, France

P206-016EFFECT OF ETHANOL ON SOME BRAIN AND HEPATIC PARAMETERS IN MALE AND FEMALE SPONTANEOUSLY HYPERTENSIVE RATS (SHRS). R. Simeonova, V. Vitcheva, M. Mitcheva. Faculty of Pharmacy, Medical University - Sofia, Sofia, Bulgaria

P206-017COMPARATIVE CHANGES IN GENE EXPRESSION PROFILES INDUCED BY PPARÃ AND PPARÁ/Ã AGONISTS IN PRIMARY HUMAN HEPATOCYTES AND HEPARG CELLS. A. Rogue (1), C. Spire (2), N. Claude (2), A. Guillouzo (1). (1) INSERM U991, RENNES, France;(2) SERVIER group, ORLEANS, France

P206-018EVALUATION OF POTENTIAL BIOMARKERS FOR THIOACETAMIDE-INDUCED HEPATOTOXICITY USING SIRNA. J. S. Kang (1), Y. N. Yum (2), S. N. Park (2). (1) Namseoul University, Cheonan, Korea, Republic of;(2) National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration,

P206-019PYRROLIZIDINE ALKALOID CLIVORINE INDUCED MITOCHONDRIAL-MEDIATED APOPTOSIS IN HEPATOCYTES AND THE PROTECTION OF NAC. L. Ji, Y. Chen, T. Liu, Z. Wang. Shanghai University of Traditional Chinese Medicine, Shanghai, China

P206-020DIFFERENTIAL RESPONSE TO TRICHLOROETHYLENE-INDUCED HEPATOSTEATOSIS IN WILD-TYPE AND PPARÁ-HUMANIZED MICE. D. H. Ramdhan (1), M. Kamijima

(2), D. Wang (1), Y. Ito (2), Y. Yanagiba (1), Y. Hayashi (1), H. Naito (1), F. J. Gonzalez (3), T. Nakajima (1). (1) Nagoya University, Graduate School of Medicine, Nagoya, Japan;(2) Nagoya City University, Graduate School of Medicine, ;(3) US National Institutes of Health, National Cancer Institute

P206-021MECHANISM ANALYSIS OF NANOPARTICLE-RICH DIESEL EXHAUST INDUCED LIVER DAMAGE IN F344 RATS. Y. Ito (1), Y. Yanagiba (2), D. H. Ramdhan (2), Y. Hayashi (2), Y. Li (2), A. K. Suzuki (3), M. Kamijima (1), T. Nakajima (2). (1) Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan;(2) Nagoya University Graduate School of Medicine, Nagoya, Japan;(3) National Institute for Environmental Studies,

P206-022OMICS PROFILING USING FFPE TISSUE BLOCKS OF A NINE YEAR OLD TOXICITY STUDY IN RATS. C. S. Schmitt, P. G. Hewitt. Merck Serono Research, Darmstadt, Germany

P206-023A SINGLE CARBON TETRACHLORIDE ADMINISTRATION INDUCES EARLY ALTERATIONS OF MITOCHONDRIAL DNA IN MOUSE LIVER, THROUGH A LIPID PEROXIDATION-DEPENDENT MECHANISM. L. Knockaert (1), A. Berson (2), A. Fautrel (1), P. E. Prost (1), C. Ribault (1), B. Fromenty (1), M. A. Robin (1). (1) INSERM U991, RENNES Cedex, France;(2) INSERM U773, PARIS, France

P206-024VANIN-1 DEFICIENT MICE HAVE ENHANCED SUSCEPTIBILITY TO ACETAMINOPHEN HEPATOTOXICITY. J. E. Manautou (1), D. W. Ferreira (1), F. Galland (2), P. Naquet (2). (1) University of Connecticut, Storrs, United States;(2) CNRS-INSERM-Université de la Méditerranée, Marseille, France

P206-025GENDER-RELATED DIFFERENCES OF THE HEPATIC ENZYME ACTIVITIES IN RELATION TO THE TOXICITY OF BENZOTRIAZOLE ULTRAVIOLET ABSORBER IN RATS. A. Ono (1), A. Hirose (1), M. Hirata-Koizumi (1), K. Matsuno (2), M. Kawabata (2), K. Yajima (2), T. Matsuyama (3), E. Kamata (1), M. Ema (1). (1) National Institute of Health Sciences, Tokyo, Japan;(2) Shin Nippon Biomedical Laboratories (SNBL), Ltd., Tokyo, Japan;(3) SNBL USA, Ltd., Everett, United States

P206-026THE ROLE OF CERAMIDE IN THE HEPATIC INSULIN RESISTANCE INDUCED BY PALMITATE IN VITRO. Y. J. Choi, H. R. Suh, B. H. Lee. Seoul National University, Seoul, Korea, Republic of

P206-027EFFECTS OF MEDICINAL HERBS AND THEIR COMPONENTS ON THE STEATOGENIC HEPATOTOXICITY. Y. J. Choi, H. R. Suh, S. M. Jeong, B. H. Lee. Seoul National University, Seoul, Korea, Republic of

P206-028PHLORETIN AND HYDROXYCHALCONES HEPATOPROTECTIVE ACTIVITY AGAINST ACETAMINOPHEN-INDUCED LIVER DAMAGE IN MICE. O. Sabzevari, S. Mahmoudian, B. Minaei, H. Paydar. Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of)

BARCELONAIUTOX 2010


69

P206-029DIOXIN-DEPENDENT RECRUITMENT OF AHR TO PROMOTER REGIONS IN MOUSE LIVER. J. Matthews (1), R. Lo (1), A. Forgacs (2), T. Celius (1), L. Macpherson (1), P. Harper

(1), T. Zacharewski (2). (1) University of Toronto, Toronto, Canada;(2) Michigan State University,

P206-030EFFECTS OF AQUEOUS EXTRACT OF BLACK MULBERRY (MORUS NIGRA) ON LIVER AND KIDNEY OF DIABETIC MICE. M. R. Hemmati, A. Hemmati, M. J. Hemmati, I. R. Hemmati, H. T. Hemmati. Azad Karaj University, Tehran Iran, Ahwaz Jundishapur University, Ahwaz Iran

P206-031ACROLEIN INDUCES HEME OXYGENASE 1 THROUGH PKC-Ä AND P38 PATHWAY IN HEPG2. J. Y. Song, H. J. Ahn Kyung Hee University, Seoul, Korea, Republic of

P206-032EVALUATION OF ZEBRAFISH AS A MODEL TO PREDICT HUMAN HEPATOTOXICITY. C Callol, A. Letamendia, O. Holgado, M. Diez. Biobide, San Sebastian, Spain

P206-033L-SERINE AMELIORATE THE ACUTE ETHANOL INDUCED STEATOSIS IN MICE BY INHIBITING THE MATURATION OF STEROL REGULATORY ELEMENT BINDING PROTEIN-1C. H. Q. Yin, Y. T. Je, H. S. Choi, B. H. Lee. College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea, Republic of

P206-034MODULATION OF HEPATIC DRUG METABOLISM IN INFLUENZA INFECTED MICE. PREVENTIVE EFFECT OF POLYPHENOLS ISOLATED FROM GERANIUM SANGUINEUM L. E. Encheva (1), L. Tancheva (1), S. Abarova (1), J. Serkedjieva (2), S. Ivantcheva (3). (1) Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria;(2) Institute of Microbiology at Bulgarian Academy of Sciences;(3) Institute of Botany at Bulgarian Academy of Sciences

P206-035GENE EXPRESSION ANALYSIS OF PRECISION CUT HUMAN LIVER SLICES INDICATE STABLE EXPRESSION OF ADME-TOX RELATED GENES. M. Elferink (1), P. Olinga

(1), E. Van Leeuwen (2), S. Bauerschmidt (2), J. Polman (2), W. Schoonen (2), S. Heisterkamp (2), G. Groothuis (1). (1) Groningen Research Institute for Pharmacy, University of Groningen, Groningen, Netherlands;(2) MSD

P206-0362,3,7,8 TETRACHLORO-DIBENZO-P-DIOXIN COUNTERACTS THE P53 RESPONSE TO A GENOTOXICANT BY UP-REGULATING EXPRESSION OF THE METASTASIS MARKER AGR2 IN THE HEPATOCARCINOMA CELL LINE HEPG2. A. Ambolet Camoit (1), L. C. Bui (1), S. Pierre (1), A. Chevallier (1), A. Marchand (2), X. Coumoul (1), M. Garlatti (1), K. Andreau (3), R. Barouki (1), M. Aggerbeck (1). (1) UMR-S 747 INSERM, PARIS, France;(2) UMR-S 956 INSERM, PARIS, France;(3) EAC CNRS 4413, PARIS, France

P206-037INDUCTION OF THE RAS ACTIVATOR SON OF SEVENLESS 1 BY ENVIRONMENTAL POLLUTANTS MEDIATES THEIR EFFECTS ON CELLULAR PROLIFERATION. S. Pierre, A. S. Bats, A. Chevallier, L. C. Bui, A. Ambolet-Camoit, M. Garlatti, M. Aggerbeck, R. Barouki, X. Coumoul. INSERM UMR-S 747, Paris, France

P206-038ANALYSIS BY TWO DIMENSIONAL ELECTROPHORESIS OF PROTEIN EXPRESSION IN LIVER OF CYNOMOLGUS MONKEYS TREATED WITH A NEW CANDIDATE DRUG UNDER NON-CLINICAL DEVELOPMENT. AN ACTIVITY OF THE MELIUS PROJECT. D. Fernandez (1), M. Conde (1), D. Nagore (1), L. Simon (1), N. Fabre (2), J. A. Vericat (2). (1) Proteomika, Derio, Spain;(2) Noscira,

P206-041ELECTROPHORETIC AND HISTOPATHOLOGICAL STUDIES ON ADULT FEMALE RATS TREATED WITH DEPO-PROVERA (DMPA). W. Abu Shaeri (1), S. Bakry (1), E. Khattab (2). (1) Zoology Department, Faculty of Science - Al Azhar University, Nasr City, Egypt;(2) , Nasr City, Egypt

P206-051CHRONIC EXPOSURE TO BENZOPHENONE INDUCED PATHOMORPHOLOGICAL AND ULTRASTRUCTURAL CHANGES IN THE LIVER OF ALBINO RAT. U. Dutta. P.G. Department of Zoology Cotton College Guwahati 781001, Guwahati, India

P206-052PROTECTIVE EFFECT OF RESVERATROL AGAINST OXIDATIVE DNA DAMAGE INDUCED BY 2-NITROPROPANE IN RAT LIVER. E. Bigagli, M. Lodovici, M. Zaid, C. Luceri, P. Dolara. University of Florence, Florence, Italy

P206-060EVALUATION OF DRUG TOXICITY USING ISOLATED MOUSE LIVER MITOCHONDRIA. M. Porceddu (1), N. Buron (1), B. Fromenty (2), A. Borgne-Sanchez (1). (1) MITOLOGICS S.A.S. Hôpital Robert Debré, Paris, France, (2) INSERM U991, Faculté de Pharmacie, Rennes, France.

P207: TARGET ORGAN TOXICITY: NEUROTOXICITY

P207-001KOLAVIRON INHIBITS APOPTOTIC CELL DEATH AND PREVENTS OXIDATIVE DAMAGE IN PC12 CELL LINE EXPOSED TO ATRAZINE. S. Abarikwu (1), M. Kashyap (2), I. Adedara (3), A. Pant (2), E. Farombi (4). (1) Biochemistry Division, Dept of Chemical Sciences, Redeemer’s University, Nigeria, Redemption City, Nigeria; (2) In vitro Toxicology Research Laboratories, IITR (Formerly Industrial Toxicology Research Center) Lucknow, India, Lucknow, India; (3) Dept of Biochemistry, Drug Metabolism and Toxicology Research Laboratories, University of Ibadan, Ibadan, Nigeria; (4) Dept of Biochemistry, Drug Metabolsim and Toxicology Research Laboratories, University of Ibadan, Ibadan, Nigeria.

P207-002INFLUENCE OF ASCORBIC ACID ON SOME NEUROBEHAVIOURAL PARAMETERS FOLLOWING REPEATED EXPOSURE TO LEAD IN RATS. O. O. Oladipo (1), J. O. Ayo

(2), S. F. Ambali (2), S. A. Ojo (3). (1) Biochemistry & AMB Division, National Veterinary Research Institute, Vom, Nigeria, Jos, Nigeria; (2) Department of Veterinary Physiology & Pharmacology, Ahmadu Bello University, Zaria, Nigeria; (3) Department of Veterinary Anatomy, Ahmadu Bello University, Zaria, Nigeria.

P207-003LONG-LASTING EFFECTS OF PERINATAL HYPOTHYROIDISM ON AUDITORY STARTLE RESPONSES AND PREPULSE INHIBITION IN WEANLING, ADULT, AND ELDERLY RATS. H. Wada, S. Yumoto. Hokkaido University, Sapporo, Japan

P207-004THE S-100B LEVELS IN THE CEREBROSPINAL FLUID AND CLINICAL PROGNOSIS IN CARBON MONOXIDE POISONING. T. Ide, Y. Kamijo, K. Yoshimura, A. Ide, T. Nishikawa, K. Soma, H. Mochizuki. Kitasato University, School of Medicine, Sagamihara, Japan


70

P207-005ESTRADIOL COUNTERACTS NMDAR INTERNALIZATION INDUCED BY LONG-TERM EXPOSURE TO DIELDRIN IN CORTICAL NEURONS. V. Briz (1), M. Galofré (1), J. Parkash (2), V. Prevot (2), C. Suñol (1). (1) Institut d’Investigacions Biomediques de Barcelona, CSIC-ISIBAPS, CIBERESP, (2) Inserm U837, Jean-Pierre Aubert Research Center, Lille Cedex, France.

P207-006CORRELATION OF BRAIN LEVELS OF FIPRONIL WITH THE NEUROTOXICOLOGICAL EFFECTS INDUCED IN RATS. E. Ramos, M. . A. Martínez, R. Pita, V. Castellano, I. Ares, V. Caballero, M. Martínez, M. R. Martínez-Larrañaga, A. Anadón. Universidad Complutense de Madrid, Madrid, Spain

P207-007ACCUMULATION AND DISPOSITION OF PYRETHROIDS IN THE RAT PERIPHERAL NERVOUS SYSTEM. I. Ares, M. Martínez, M. A. Martínez, V. Castellano, E. Ramos, M. R. Martínez-Larrañaga, A. Anadón. Universidad Complutense de Madrid, Madrid, Spain

P207-008MELATONIN INCREASES GENE EXPRESSION OF SUPEROXIDE DISMUTASE AND CATALASE IN BRAIN OF A¥ÂPP TRANSGENIC MICE AFTER CHRONIC EXPOSURE TO ALUMINUM. T. García, M. Gómez, J. L. Esparza, M. Cabré, J. L. Domingo. Universitat Rovira i Virgili, Reus, Spain

P207-009THE PROXIMAL AXONOPATHY CAUSED BY 3,3-IMNODIPROPIONITRILE (IDPN) IN RATS IS NOT ASSOCIATED WITH A DISTO-PROXIMAL ADVANCEMENT OF NEUROFILAMENT DEPLETION IN MOTOR TERMINALS. C. Soler-Martín (1), Ú. Vilardosa (1), S. Saldaña-Ruíz (1), N. Garcia (2), J. Llorens (1). (1) Universitat de Barcelona, Hospitalet de Llobregat, Spain; (2) Universitat Rovira i Virgili, Reus.

P207-010DEVELOPMENTAL NEUROTOXICITY TESTING: LOCOMOTOR ACTIVITY IN ZEBRAFISH AN ALTERNATIVE? I. Waalkens-Berendsen (1), C. De Esch (1), H. Van Der Linde (2), D. De Groot (1), R. Willemsen (2), A. Wolterbeek (1). (1) TNO Quality of Life, Zeist, Netherlands; (2) Erasmus MC, Rotterdam, Netherlands

P207-011IPD STUDIES AND NEUROBEHAVIORAL TOXICOLOGY MEANS FOR ACHIEVING THE REQUIRED COMPARABILITY OF DATA. M. Meyer-Baron (1), M. Schäper (1), C. Van Thriel (1), G. Knapp (2), R. Lucchini (3), R. Bast-Pettersen (4), X. L. Wang (5), S. He (6), B. Sjögren (7), M. Blond (8), D. Mergler (9). (1) Leibniz Research Centre for Working Environment and Human Factors, Germany, Dortmund, Germany; (2) TU Dortmund University, Department of Statistics, Dortmund, Germany; (3) Occupational Health and Industrial Hygiene, University of Brescia, Italy; (4) National Institute of Occupational Health, Oslo, Norway; (5) Division of Environmental Pollution and Human Health, Chinese Research Academy of Environmental Science, Beijing, China; (6) Department of Psychology, Peking University, China; (7) Work Environment Toxicology, Karolinska Institutet, Stockholm, Sweden; (8) Clinic of Occupational Medicine, Nykoebing, Denmark; (9) University of Quebec, Montreal, Canada.

P207-012CYP2E1-DEPENDENT DIFFERENCES IN NITRILE LETHAL AND VESTIBULOTOXIC EFFECTS IN MICE REVEALED BY A NEW ACUTE TOXICITY TEST PROTOCOL. S. Saldaña-Ruíz, C. Soler-Martín, B. Cutillas, J. Llorens. Universitat de Barcelona, Hospitalet de Llobregat, Spain

P207-013NEUROTOXICITY OF “ECSTASY” AND ITS METABOLITES IN HUMAN DOPAMINERGIC DIFFERENTIATED SH-SY5Y CELLS. P. S. Ferreira (1), P. S. Branco (2), L. M. Ferreira

(2), E. Fernandes (3), M. L. Bastos (1), A. Meisel (4), F. Carvalho (1), J. P. Capela (1). (1) REQUIMTE (Rede de Química e Tecnologia), Toxicology Dept, Faculty of Pharmacy, University of Porto, Rua Aníbal Cunha 164, 4099-030 Porto, Portugal, Porto, Portugal; (2) REQUIMTE/CQFB, Departamento de Química, FCT, Universidade Nova de Lisboa, Portugal; (3) REQUIMTE (Rede de Química e Tecnologia), Physical Chemistry Dept., Faculty of Pharmacy, University of Porto, Rua Aníbal Cunha 164, 4099-030 Porto, Portugal; (4) Department of Experimental Neurology, NeuroCure Clinical Research Center, Charité-Universitaetsmedizin Berlin, Charitéplatz 1 D-10117 Berlin, Germany.

P207-014DIFFERENTIAL EFFECTS OF EARLY EXPOSITION TO DECA-BROMO DIPHENIL ETHER IN APOE4, APOE3 AND APOE2 YOUNG MICE. I. Reverté, J. G. Salazar, D. Ribes, J. L. Domingo, M. T. Colomina. University Rovira i Virgili, Tarragona, Spain

P207-015ANXIETY, SENSORIOMOTOR COORDINATION AND NEUROGENESIS IN TG2576 MICE EXPOSED TO ALUMINUM. D. Ribes, P. Vicens, J. L. Domingo, M. T. Colomina. “Rovira i Virgili” University, Tarragona, Spain

P207-016DOXORUBICIN ACTIVATES APOPTOSIS IN PRIMARY NEURONAL CULTURES OF RAT CEREBRAL CORTEX THROUGH P53-MEDIATED PATHWAYS. M. Lopes (1), A. Meisel (2), F. Carvalho (1), M. L. Bastos (1). (1) Faculty of Pharmacy, University of Porto, Porto, Portugal; (2) Charité-Universitätsmedizin Berlin, Germany

P207-017CHLORPROMAZINE AND AMPHETAMINE INDUCE BI-DIRECTIONAL CHANGES IN STARTLE RESPONSE AND MOTOR ACTIVITY IN JUVENILE AND ADULT RATS: A VALIDATION STUDY. M. Beekhuijzen, A. Zmarowski, M. De Raaf, H. Emmen, W. Frieling. NOTOX B.V., ‘s-Hertogenbosch, Netherlands

P207-018COGNITIVE AND MOLECULAR RESPONSES OF CENTRAL NERVOUS SYSTEM AFTER CHRONIC EXPOSURE TO URANIUM. P. Lestaevel, H. Bensoussan, B. Dhieux, I. Dublineau, P. Voisin, P. Gourmelon. IRSN, Fontenay aux Roses, France

P207-019THE BROMINATED FLAME RETARDANTS HEXABROMOCYCLODODECANE (HBCD) AND BDE-47 AFFECT CALCIUM HOMEOSTASIS IN RAT PC12 CELLS. R. Westerink (1), H. Heusinkveld (1), A. Bergman (2), M. Van Den Berg (1), M. Dingemans (1). (1) Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands; (2) Department of Environmental Chemistry, Stockholm University.

P207-020EFFECTS OF AMPHETAMINE ON NEUROTRANSMITTER RELEASE IN PC12 AND CHROMAFFIN CELLS. L. Hondebrink (1), J. T. Timmerman (1), M. Berg Van Den (1), J. Meulenbelt (2), R. Westerink (1). (1) Utrecht University, Institute for Risk Assessment Sciences, Utrecht, Netherlands; (2) The National Poisons Information Centre, The National Institute for Public health and Environment, Bilthoven, Netherlands.

P207-021GLYCOGEN SYNTHASE KINASE 3 BETA (GSK3BETA) AS A PROMISING TARGET TO PREVENT BETA-AMYLOÏDE AND TAU TOXICITY IN ALZHEIMER DISEASE. B. Fauconneau, A. Noel, L. Barrier, G. Prie, S. Ingrand. University of Poitiers, Poitiers, France

BARCELONAIUTOX 2010


71

P207-022NEUROBEHAVIOURAL TOXICITY OF A 14-DAY EXPOSURE TO THE AIRBORNE POLYCYCLIC AROMATIC HYDROCARBON FLUORENE IN ADULT WISTAR MALE RATS. J. Peiffer (1), F. Cosnier (2), S. Wagner (1), M. J. Decret (2), B. Cossec (2), G. Rychen (1), H. Schroeder (1). (1) UR AFPA - Unité de Recherche Animal et Fonctionnalités des Produits Animaux, Vandoeuvre-lès-Nancy, France, Metropolitan; (2) INRS - Institut National de Recherche et de Sécurité, Vandoeuvre-lès-Nancy, France, Metropolitan

P207-023ARSENIC (III) METHYLTRANSFERASE EXPRESSION AND ARSENIC METABOLITES ACCUMULATION IN BRAIN REGIONS OF MICE EXPOSED TO ARSENITE. C. Valdovinos Flores(1), L. C. Sánchez Peña(2), P. Petrosian(1), M. Morales(1), N. B. González(1), G. Gutiérrez-Ospina(1), L. M. Del Razo(2), M. E. Gonsebatt (1). (1) 52-555-622-9179, Mexico, Mexico; (2) ., Mexico

P207-024NEUROTOXICITY EFFECTS TWO MONTHS AFTER EXPOSURE TO REPEATED DOSES OF CHLORPYRIFOS IN AN ANIMAL MODEL (TG2576) OF ALZHEIMER`S DISEASE. J. G. Salazar (1), I. Reverté (1), M. Cabré (1), F. Sánchez-Santed (2), J. L. Domingo (1), M. T. Colomina (1). (1) Universitat Rovira i Virgili, Tarragona, Spain; (2) Universidad de Almería.

P207-025ACUTE TOXICITY OF MONOCROTALINE EXTRACTED FROM CROTALARIA SPECTABILIS: BEHAVIORAL AND MACROSCOPIC EVALUATIONS IN RATS. D. P. Dalmolin, C. S. Telloli, E. L. Ricci, T. M. Reis-Silva, H. S. Spinosa, S. L. Górniak, M. M. Bernardi. School Of Veterinary Medicine And Animal Science, University Of São Paulo, Sp, Brazil

P207-026BEHAVIORAL TOXICITY OF AN ORAL CHRONIC ADMINISTRATION (90 DAYS) OF RAW COW’S MILK CONTAMINATED WITH POLYCHLORINATEDBIPHENYLS (PCBS) IN ADULT MALE RATS. H. Schroeder, G. Streit, M. Condé, G. Rychen, C. Feidt. URAFPA, INRA USC340, Vandoeuvre les Nancy Cédex, France

P207-027EFFECTS OF ENVIRONMENTAL CONTAMINANTS EXPOSURE ON SPATIAL ORIENTATION OF VISUAL ATTENTION IN CHILDREN: A STUDY FROM ARCTIC QUEBEC. A. A. Ethier (1), C. Polevoy (2), G. Muckle (3), C. Bastien (3), E. Dewailly (4), P. Ayotte (4), P. Plusquellec (4), S. Jacobson (5), J. Jacobson (5), D. Saint-Amour (2). (1) University of Montreal, Montreal, Canada; (2) Sainte-Justine Hospital; (3) Laval University; (4) Public Health Research Unit; (5) Department of Psychiatry and Behavioral Neurosciences, Wayne State University.

P207-028CHRONIC DIETARY AND ACUTE EXPOSURE TO CHLORPYRIFOS IN RATS: NEUROBEHAVIOURAL AND NEUROCHEMICAL CORRELATES. J. Barril (1), C. López-Granero (2), D. Cardona (2), E. Giménez (2), F. Sánchez-Santed (2), M. D. L. C. Pellín (1), J. Esteban (1), F. Cañadas (2). (1) Universitat Miguel Hernández d’Elx, Elx, Spain; (2) Universidad de Almería.

P207-029MODULATION OF THE INFLAMMATORY RESPONSE IN GLIA AND MACROPHAGES BY THE HISTONE DEACETYLASE INHIBITOR,TRICHOSTATIN A. M. Boraso, I. Lotterio, E. Picerno, V. Galbiati, E. Corsini, C. L. Galli, M. Marinovich, B. Viviani. University of Milan, Milan, Italy

P207-030AGGRESSIVE BEHAVIOR IN RATS EXPOSED TO CADMIUM AND SUBMITTED TO IMOBILIZATION STRESS. A. A. Almeida, S. G. Terçariol, A. F. Godinho. Universidade Estadual Paulista - UNESP, Botucatu, Brazil

P207-031SCREENING STUDIES IN SELECTION A CHEMICAL STRUCTURE PHARMACOLOGICALLY ACTIVE IN THE NEUROTOXIC COMPOUNDS POISONING. S. Cristina Anca. Army Centre of Medical Research, Bucharest Romania, BUCHAREST, Romania

P207-032PROTECTIVE EFFECTS OF GANGLIOSIDE GT1B OR MELATONIN AGAINST KAINATE-INDUCED NEUROTOXICITY IN ANIMAL. H. A. Yamamoto. University of Tsukuba, Graduate School of Comprehensive Human Sciences, Tsukuba, Japan

P207-033THE CHANGES OF CALPAINS IN RAT SCIATIC NERVES INDUCED BY 2,5-HEXANEDIONE. F. Song, K. Xie. Institute of toxicology, Shandong University, Jinan, China

P207-034SUSTAINED PRODUCTION OF REELIN-EXPRESSING INTERNEURONS IN THE HIPPOCAMPAL DENTATE HILUS AFTER DEVELOPMENTAL HYPOTHYROIDISM IN RATS. Y. Saegusa (1), G. H. Woo (2), H. Fujimoto (2), S. Kemmochi (1), K. Shimamoto (1), M. Hirose (3), K. Mitsumori (1), A. Nishikawa (2), M. Shibutani (1). (1) Tokyo University of Agriculture and Technology, Fuchu-shi, Japan; (2) National Institute of Health Sciences, Japan; (3) Food Safety Commission.

P207-035TIME-DEPENDENT ELECTROPHYSIOLOGIC CHANGES OF SCIATIC-TIBIAL NERVE IN HENS INDUCED BY TRI-ORTHO-CRESYL PHOSPHATE. X. Zhao, C. Zhang, Z. Zhu, L. Yu, K. Xie. Institute of Toxicology,Shandong University, Jinan, China

P207-036SUSTAINED PRODUCTION OF REELIN-EXPRESSING INTERNEURONS IN THE HIPPOCAMPAL DENTATE HILUS AFTER DEVELOPMENTAL HYPOTHYROIDISM IN RATS. Y. Saegusa (1), G. H. Woo (2), H. Fujimoto (2), S. Kemmochi (1), K. Shimamoto (1), L. Wang (1), A. Nishikawa (2), K. Mitsumori (1), M. Shibutani (1). (1) Tokyo University of Agriculture and Technology, Fuchu-shi, Japan; (2) National Institute of Health Sciences.

P207-037EVALUATION OF THE OXIDATIVE DAMAGE INDUCED BY MDMA AND ITS METABOLITES IN RAT BRAIN SYNAPTOSOMES. D. J. Barbosa (1), L. Ferreira (2), P. Serio Branco

(2), E. Fernandes (3), H. Carmo (1), F. Remião (1), M. L. Bastos (1), J. Oliveira (4), J. P. Capela (5), F. Carvalho (1). (1) REQUIMTE (Rede de Química e Tecnologia), Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal; (2) REQUIMTE/CQFB, Chemistry Department, FCT, Universidade Nova de Lisboa, Portugal; (3) REQUIMTE, Physical Chemistry Department, Faculty of Pharmacy, University of Porto, Porto, Portugal; (4) Pharmacology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal; (5) Faculty of Health Sciences, Universidade Fernando Pessoa, Porto / Porto, Portugal

P207-045DOMOIC ACID-INDUCED NEUROTOXICITY IS MAINLY MEDIATED BY THE AMPA RECEPTOR: COMPARISON BETWEEN IMMATURE AND MATURE PRIMARY CULTURES OF CEREBELLAR GRANULE CELLS. H. Hogberg (1), A. Price (2). (1) The Johns Hopkins University, Baltimore, United States; (2) European Commission Joint Research Centre.

P207-048CHANGES OF MITOCHONDRIAL ULTRASTRUCTURES AND FUNCTION IN NERVE TISSUE OF HENS TREATED WITH TRI-ORTHO-CRESYL PHOSPHATE (TOCP). X. Xin (1), T. Zeng (1), D. D. Dou (1), S. Zhao (1), J. Y. Du (2), J. J. Pei (2), K. Q. Xie (1), X. L. Zhao (1). (1) Institute of Toxicology, Shandong University, Jinan, China; (2) .


72

P207-049SSAMYLOID INDUCE APOPTOSIS, MITOCHONDRIAL INJURY, OXIDATIVE STRASS AND P2X7 CELL DEATH RECEPTOR MODULATION IN HUMAN RETINA CELL - ROLE IN AGE-RELATED MACULAR DEGENERATION. P. Rat, B. De Moucheron, F. Massicot, I. Celerier, J. M. Warnet, O. Laprevote. Université Paris Descartes, PARIS, France

P208: TARGET ORGAN TOXICITY: OTHER

P208-001IMPROVEMENT OF TOXIC STRESS IN RAT IMMUNOLOGICAL COLITIS BY A NEW HERBAL COMBINATION. M. Abdollahi, A. Baghaei, H. Esmaily, A. H. Abdolghaffari, M. Baeeri. Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of)

P208-002DIESEL EXHAUST PARTICLES IN THE LUNG AGGRAVATE EXPERIMENTAL ACUTE RENAL FAILURE . I. Al Husseni (1), B. Ali (1), S. Al-Salam (2), A. Nemmar (2), J. Yasin (3), S. Zia (3). (1) Sultan Qaboos University, Al Khod, Oman; (2) United Arab Emirates, University; (3) Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates

P208-003TOXICOLOGICAL EVALUATION OF SMOKELESS TOBACCO: 90-DAY RODENT FEEDING STUDIES. E. Theophilus (1), J. Hayes (1), R. Potts (1), P. Ayres (1), C. Williams (1), C. Garner (1), M. Hejtmancik (2), D. Fallacara, A. Singer (2). (1) RJRT, Winston-Salem, United States; (2) Battelle, United States

P208-004ANALYSIS OF CLINICAL RELEVANCE OF CARDIAC LESIONS SEEN IN A HIGH DOSE RAT FROM A TOXICITY STUDY. G. Hanton (1), S. De Jonghe (2), W. Roosen (2), L. Lammens (2), A. Vynckier (2), M. Martens (1). (1) Johnson and Johnson (Tibotec), Mechelen, Belgium; (2) Johnson and Johnson (PRDBE)

P208-005OXIDATION OF ALCOHOL TO ACETALDEHYDE, HYDROXYL RADICAL FORMATION, AND OXIDATIVE STRESS IN THE RAT UTERUS. THEIR RELATION TO REPRODUCTIVE TOXICITY. G. Castro, L. Buthet, S. Fanelli, C. Rodríguez De Castro, M. Costantini, F. Bietto, J. Castro. CITEFA-CONICET, Villa Martelli, Argentina

P208-006INHIBITORY EFFECTS OF SOME PLANT POLYPHENOLS ON THE RAT MAMMARY MICROSOMAL BIOACTIVATION OF ETHANOL TO ACETALDEHYDE. J. Castro, M. Maciel, G. Castro. CITEFA-CONICET, Villa Martelli, Argentina

P208-007TOXICITY STUDY OF THE CO-ADMINISTRATION OF ARTESUNATE AND SULPHADOXINE/PYRIMETHAMINE USING SELECTED BIOCHEMICAL PARAMETERS IN RATS. J. Adebayo, C. Nwonuma, R. Arise, E. Balogun. University of Ilorin, Ilorin, Nigeria

P208-008RELATIONSHIP OF ADIPONECRIN GENE SNPS AND RISK OF TYPE 2 DIABETES IN OBESE SUBJECTS. G. Mohammadzadeh (1), N. Zarghami (2). (1) Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Ahvaz, Iran (Islamic Republic of); (2) Tabriz university of medical sciences, Tabriz ,Iran, Tabriz, Iran (Islamic Republic of)

P208-009RELATIONSHIP OF ADIPONECTIN TO ANTHROPOMETRIC INDICES AND METABOLIC FACTORS IN OBESE SUBJECTS WITH TYPE 2 DIABETES. M. Mehrab Pour, G. Mohammadzadeh. Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran (Islamic Republic of)

P208-010PROCOAGULANT AND PROTHROMBOTIC ACTIVATION OF HUMAN ERYTHROCYTE. J. Y. Noh, K. M. Lim, S. W. Lee, S. D. Lee, J. H. Chung. Seoul National University, Seoul, Korea, Republic of

P208-011PROTECTIVE EFFECT OF POMEGRANATE SEED OIL AGAINST GENTAMICIN INDUCED NEPHROTOXICITY IN RAT. E. Asadpour, M. T. Boroushaki, H. Sadeghnia. Mashhad University of Medical Sciences, Mashhad, Iran (Islamic Republic of)

P208-012INHIBITORY ROLE OF THE NRF2-HEME OXYGENASE-1 SYSTEM IN CYCLOSPORINE A-INDUCED EPITHELIAL-MESENCHYMAL TRANSITION AND RENAL FIBROSIS. M. K. Kwak. Yeungnam University, College of Pharmacy, Gyeongsan, Korea, Republic of

P208-013COMPARISON OF THE DIGESTIVE EFFECTS OF THE FOOD CONTAMINANT DON AND OF TWO ACETYL DERIVATIVES BY IN VITRO AND EX VIVO APPROACH. P. Pinton (1), D. Tsybulskyy (1), B. Joly (2), N. Bourges-Abella (2), I. P. Oswald (1), M. Kolf-Clauw (3). (1) Laboratoire de Pharmacologie et Toxicologie UR66, France; (2) Université de Toulouse; (3) Université de Toulouse, Ecole Nationale Vétérinaire

P208-014MORPHOMETRIC EVALUATION OF SEMINIFEROUS TUBULES IN AGED MICE TESTES AFTER MELATONIN ADMINISTRATION. F. Mehraein Ghomi. Medical school, Iran University of Medical Sciences, Tehran, Iran (Islamic Republic of)

P208-015MONENSIN TOXICITY AND ACUTE LETHAL RHABDOMYOLYSIS IN ACCIDENTAL EXPOSURE IN CATTLE. I. Vickovic (1), B. Sostaric (2), J. Toncic (1). (1) Institute for medical Research and Occupational Health, Zagreb, Croatia, Zagreb, Croatia (Hrvatska); (2) Croatian Veterinary Institute, Zagreb, Croatia

P208-016CROTONALDEHYDE INDUCES ADAPTIVE RESPONSE THROUGH UPREGULATE OF HO-1 IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS. S. E. Lee, H. N. Yang, D. S. Ryu, S. I. Jeong, Y. S. Park. Kyung Hee University, seoul, Korea, Republic of

P208-017EXPRESSION PROFILE ANALYSIS OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS TREATED WITH METHYLGLYOXAL H. Yang, S. E. Lee, D. S. Ryu, Y. S. Park. Kyung Hee University, Seoul, Korea, Republic of

P208-018STUDIES ON GENE PROFILES BY TREATMENT OF CROTONALDEHYDE IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS. S. I. Jeong, S. E. Lee, Y. S. Park. Kyung Hee University, Seoul, Korea, Republic of

BARCELONAIUTOX 2010


73

P208-019THE PHARMACOKINETICS OF INTRAGASTRICALLY ADMINISTERED 13C-D-XYLOSE IN EXPERIMENTAL PIGS UNDER THE THUMB OF GASTROINTESTINAL LESIONS (INDUCED WITH INDOMETHACIN) AND PROBIOTIC ESCHERICHIA COLI NISSLE MEDICATION. M. Kunes (1), J. Kvetina (1), J. Bures (2), V. Vorisek (3), H. Tlaskalova (4). (1) Institute of Experimental Biopharmaceutics, PRO.MED.CS Praha a.s. and the Czech Academy of Sciences, Hradec Kralove, Czech Republic; (2) Second Department of Internal Medicine, Charles University in Praha, Faculty of Medicine at Hradec Kralove, University Teaching Hospital; (3) Institute of Clinical Biochemistry and Diagnostics, University Teaching Hospital; (4) Institute of Microbiology, the Czech Academy of Sciences.

P208-020STUDY ON THE ETIOLOGY OF THE TOXIC NECROSIS OF CARP GILLS. H. Kroupova (1), J. Machova (1), R. Faina (1), L. Groch (2), Z. Svobodova (2). (1) University of South Bohemia in Ceske Budejovice, Vodnany, Czech Republic; (2) University of Veterinary and Pharmaceutical Sciences

P208-021BIOCHEMICAL AND HISTOLOGICAL EVALUATIONS OF DICARBOXIMIDE FUNGICIDE VINCLOZOLIN ON PREGNANT WISTAR ALBINO RATS. E. A. Koçkaya (1), E. Karacaoğlu (2), A. Kılıç (2), G. Selmanoğlu (2). (1) Gazi University, Ankara, Turkey; (2) Hacettepe University

P208-022MELATONIN LIMITS CYCLOSPORINE TOXICITY BY REDUCING ER CHAPERONES IN THE RAT. A. Stacchiotti, F. Bonomini, C. Rossini, R. Rezzani. Dept.Biomedical Sciences And Biotechnology, University Of Brescia, Italy

P208-023EFFECT OF PLATYCODON GRANDIFLORUM ROOT-DERIVED SAPONINS ON NITRIC OXIDE SYNTHASE IN HUMAN ENDOTHELIAL CELLS. H. G. Kim, H. G. Jeong. Chungnam National University, Daejeon, Korea, Republic of

P208-024COMBINATION EFFECTS OF PCB 126 AND 17BETA-ESTRADIOL IN HUMAN ENDOTHELIAL CELLS. H. Andersson, E. Brittebo. Uppsala University, Uppsala, Sweden

P208-025A STUDY ON HISTOPATHOLOGICAL CHANGES OF GASTRIC PARIETAL CELLS OBSERVED IN BEAGLE DOGS WITH DECREASED FOOD CONSUMPTION. O. Sawamoto, T. Fukuda, Y. Hayami, Y. Nakashima. Otsuka Pharmaceutical Factory, Inc., Naruto, Japan

P208-026ECG ACQUISITION IN FREELY-MOVING CYNOMOLGUS MONKEYS USING EXTERNAL TELEMETRY FOR TOXICOLOGY (ET2) SYSTEM VERSUS CONVENTIONAL (SNAPSHOT) ECG RECORDING IN CHAIR-RESTRAINED ANIMALS. SENSITIVITIY VALIDATION WITH DOFETILIDE, A QT-INTERVAL PROLONGING DRUG. J. P. Briffaux, E. Chalencon, C. Bory, P. Legé, S. Baudet, S. Milano. MDS Pharma Services, Lyon, France

P208-027EFFECTS OF CERTAIN NATURAL PHENOLIC COMPOUNDS ON EXPERIMENTAL DIABETES AND RESPONSE IN SMOOTH MUSCLES OF STZ-DIABETIC RATS ILEUM. N. Bektaş, Y. Öztürk. Anadolu University Faculty Of Pharmacy, ESKISEHIR, Turkey

P208-028MIOTIC RESPONSE BRINGS DOWNWARD ECTOPIC PUPIL AS AN INDICATOR FOR OCULAR COLOBOMA IN ALBINO MICE. T. Matsuura, A. Nakatani, K. Ozaki, I. Narama. Setsunan University, Hirakata, Japan

P208-029RELATIONSHIP BETWEEN DRUG-INDUCED RETINAL DEGENERATION AND DELAYED APOPTOSIS OF RETINAL CAPILLARY CELLS IN MICE. A. Nakatani, T. Matsuura, K. Ozaki, I. Narama. Setsunan University, Hirakata, Japan

P208-030EARLY IMMUNE SYSTEM ACTIVATION: SEXUALLY DIMORPHIC TOXIC EFFECTS OF LIPOPOLYSACCHARIDE(LPS) ON BEHAVIOUR AND IMMUNE PARAMETERS OF RATS. M. M. Bernardi, L. P. Teixeira. University of São Paulo, Paulista University, São Paulo, Brazil

P208-031METFORMIN PREVENTS FUNCTIONAL AND HISTOLOGIC ALTERATIONS OF GENTAMICIN-INDUCED NEPHROTOXICITY. M. Prieto, L. Vicente Vicente, P. D. Sánchez González, M. Y. El-Mir, D. Detaille, J. M. López Novoa, A. I. Morales. Universidad de Salamanca, Salamanca, Spain

P208-032EFFECT OF HIGH DOSE SIBUTRAMINE APPLICATION ON SERUM SEROTONIN, PLASMA NORADRENALINE AND ON ZINC AND IRON LEVELS IN LIVER, KIDNEY, ADRENAL GLANDS IN RATS. E. Emer (1), B. Kaplan (2), S. Kaya (1), V. Aliyev (1), E. Arıca (1), T. Soylemezoglu (1). (1) Ankara University Institute of Forensic Medicine, Ankara, Turkey; (2) Gazi University Vocational High School of Health Sciences, Ankara, Turkey

P208-033EFFECTS OF CITRININ TREATEMENT ON OXIDATIVE STRESS IN RAT KIDNEY. D. Flajs, D. Želježić, M. Mladinić, M. Peraica. Institute for Medical Research and Occupational Health, Zagreb, Croatia (Hrvatska)

P208-034THE TIME COURSE OF KIDNEY LESIONS IN OCHRATOXIN A TREATEMENT. M. Peraica, D. Flajs. Institute for Medical Research and Occupational Health, zagreb, Croatia (Hrvatska)

P208-035THE ARYL HYDROCARBON RECEPTOR IN HUMAN KERATINOCYTES: RELEVANCE TO CHLORACNE. A. Forrester (1), M. Graham (2), F. Williams (1), N. Reynolds

(1). (1) Newcastle University, Newcastle upon Tyne, United Kingdom; (2) Astra Zeneca R&D Charnwood

P208-036DEVELOPMENT OF A MECHANISTIC QSAR MODEL FOR THE DETECTION OF PHOTOTOXIC CHEMICALS & USE IN AN INTEGRATED TESTING STRATEGY. S. Ringeissen (1), L. Marrot (1), R. Note (1), A. Labarussiat (1), S. Imbert (1), M. Todorov (2), O. Mekenyan (2), J. R. Meunier (1). (1) L’Oréal, Aulnay sous Bois, France; (2) Laboratory of Mathematical Chemistry

P208-037NEW DIAGNOSTIC MARKERS OF ACUTE RENAL FAILURE INDUCED BY GENTAMICIN. Y. Quiros Luis (1), S. M. Sancho Martínez (1), F. J. López Hernández (2), J. M. López Novoa (1), M. Prieto (1). (1) Universidad de Salamanca, Salamanca, Spain; (2) Hospital Universitario de Salamanca.


74

P208-038EARLY ENERGETIC CATASTROPHE DOES NOT PREVENT THE EXECUTION OF APOPTOSIS INDUCED BY CISPLATIN. S. M. Sancho-Martínez (1), F. J. López-Hernández

(2), J. M. López-Novoa (1), A. I. Morales (1). (1) Área De Toxicología. Departamento De Fisiología Y Farmacología. Universidad De Salamanca. Salamanca, Spain, (2) Hospital Universitario De Salamanca, Unidad De Investigación, Salamanca, Spain.

P208-039ACTIVATION OF NRF2 TRANSCRIPTION FACTOR IN AORTA AND LUNG OF RATS EXPOSED TO FINE AND ULTRAFINE AMBIENT PARTICULATE MATTER IN MEXICO CITY. A. Valdes-Arzate (1), M. Uribe-Ramirez (1), L. E. Gomez-Quiroz (2), M. C. Gutierrez-Ruiz (2), A. Eiguren-Fernandez (3), K. Salazar (4), G. Gookin (4), M. Kleinman (4), A. De Vizcaya-Ruiz (1). (1) CINVESTAV-IPN,Mexico (2) Universidad Autonoma Metropolitana-Iztapalapa, (3) University Of California-Los Angeles, (4) University Of California-Irvine.

P208-040POSSIBLE INVOLVEMENT OF P53 MEDIATED PATHWAYS IN THE MYELOSUPPRESSION INDUCED BY 5-FU. S. Miyake, K. Sugihara, S. Numazawa, T. Yoshida. School of Pharmacy, Showa University, Shinagawa-ku, Japan

P208-041INHIBITORY EFFECT OF SESAMOL ON LPS-MEDIATED INFLAMMATORY RESPONSE. J. Uehara, S. Shindo, S. Numazawa, T. Yoshida. School of Pharmacy Showa University, shinagawa-ku, Japan

P208-042PROTECTIVE EFFECT OF CETIRIZINE ON BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN RAT. A. A. Hemmati, K. M. Hemmati, G. M. Hemmati, R. I. Hemmati, M. P. Hemmati. School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran, Ahwaz, Iran (Islamic Republic of)

P208-043RENOPROTECTIVE EFFECTS OF QUERCETIN ON CISPLATIN-INDUCED NEPHROTOXICITY. ROLE OF TNF-ALPHA, NF-KAPPAB AND INOS. P. Sánchez-González, F. J. López-Hernández, M. Prierto, L. Vicente-Vicente, J. M. López-Novoa, A. I. Morales. Universidad de Salamanca, Spain

P208-044STUDY OF THE EFFCT OF CYPROHEPTADIN ON BLOOD GLUCOSE LEVEL AND INSULIN SECRETION IN RAT. L. Arzi, Z. A. S. Arzi, A. Arzi, G. A. Arzi. Institute of biochemistry and biophysic, Tehran univesity, Shahid Beheshti University. Jundishapur University of Medical Sciences, Ahwaz, Iran, Ahwaz, Iran (Islamic Republic of)

P208-045CORRELATION BETWEEN DIABETES MELLITUS, MALNUTRITION AND CASSAVA-DERIVED CYANOGENIC TOXICITY IN SOUTH-KIVU (DEMOCRATIC REPUBLIC OF CONGO, DRC): PRELIMINARY RESULTS. C. Masheka (1), K. Bamubenga (2), W. Bisimwa (2), W. Munganga (2), R. Mushamuka (2), J. N. Chabwine (1). (1) Salama Neuroscience Center of Bukavu, Bukavu, Congo, The Democratic Republic of the; (2) Catholic University of Bukavu.

P208-046SOME MOTOR AND BEHAVIORAL CHANGES IN RATS WITH ADENINE-INDUCED CHRONIC RENAL FAILURE: INFLUENCE OF ACACIA GUM TREATMENT. B. Ali (1), A. Ziada (1), I. Al Husseni (1), S. Beegam (1), A. Nemmar (2). (1) Sultan Qaboos University, Al Khod, Oman; (2) , Al Ain, United Arab Emirates.

P208-047UPTAKE OF MODIFIED LDLS IN HEPG2 CELLS AND CHOLESTEROL ACCUMULATION BY MODIFIED LDLS IN THP-1 MACROPHAGES. K. W. Lee, S. J. Kim. Korea University, Seoul, Korea, Republic of

P208-048HYPOGLYCEMIC ACTIVITY OF CARROT SEEDS ETHANOLIC EXTRACT ON LIVER TISSUE IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. A. Khaki (1), F. Fathi Azad

(2), A. A. Khaki (2). (1) Islamic Azad University Tabriz Branch-Iran., Tabriz, Iran (Islamic Republic of); (2) Tabriz University of Medical Sciences, Iran., Tabriz, Iran (Islamic Republic of)

P208-049ESSENTIAL ROLE OF PIN1 IN THE INTIMAL HYPERPLASIA. J. W. Lee, J. W. Kim, K. W. Kang. College of Pharmacy, Chosun University, Gwangju, Korea, Republic of

P208-050THE CARDIOTOXICITY OF TRIPTOLIDE. J. Ma (1), H. Li (1), G. Hsu (1), X. Wang (2). (1) National Shanghai Center for New Drug Safety Evaluation and Research, Shanghai, China; (2)

ACEA Biosciences Inc, San Diego, US,

P208-051DETECTION OF ARISTOLOCHIC ACID INDUCED RENAL DAMAGE BY NEW URINARY AND TRANSCRIPTIONAL BIOMARKERS. T. C. Fuchs (1), A. Mally (2), M. Beiman (3), A. Wool (3), P. Hewitt (1). (1) Institute of Toxicology, Merck Serono, Darmstadt, Germany; (2) Department of Toxicology, University of Wuerzburg; (3) Compugen Ltd., Tel Aviv, Israel

P208-052EARLY DETECTION OF PHOSPHOLIPIDOSIS IN PERIPHERAL LEUKOCYTES OF MOUSE. E. Jimenez (1), P. Castañeda (2), I. Camino (2), G. Garcia (2), M. Leiros (2), E. Kleymenova (3), S. Ferrer (2). (1) GSK, TRES CANTOS, Spain; (2) GlaxoSmithKline DDW Tres Cantos (Madrid), Spain; (3) GlaxoSmithKline R&D Research Triangle Park (NC)

P208-053GENE EXPRESSION APPROACH TO EVALUATE KIDNEY INJURY MOLECULE-1 (KIM-1) AS A PREDICTIVE MARKER FOR RENAL TOXICITY. A. Chiusolo (1), R. Defazio

(1), P. Cristofori (1), M. Mongillo (2), E. Zanetto (2), A. Trevisan (2). (1) GlaxoSmithKline Research Centre, Verona, Italy; (2) University, Padua, Italy

P208-054IN VIVO EVALUATION OF SKIN DECONTAMINANTS AGAINST CHEMICAL WARFARE AGENT VX. A. Bazire, D. Baubichon, C. Cruz, R. Bifarella, D. Josse. IRBA-CRSSA, La Tronche, France

P208-055EVALUATION OF THE TOXICITY AND THE HYPOLIPIDEMIC ACTION OF BRILLANTAISIA VOGELIANA IN RATS. J. Ngogang, C. Ngadjui, K. Noubissie. University of Yaounde1, Yaounde, Cameroon

P208-056ALTERATIONS OF LUNG TISSUE AND SERUM CYTOKINES IN A RAT MODEL OF PARAQUAT-INDUCED LUNG INJURY. A. Zira, C. Giaginis, C. Maravelias, C. Spiliopoulou, S. Theocharis. University of Athens, Medical School, Athens, Greece

P208-057OXIDATIVE STRESS AND DNA DAMAGE IN MICE KIDNEY EXPOSURE TO CADMIUM CHLORIDE. M. Jafari Sani (1), A. Zarei Mahmud Abadi (1), M. Adelipur (1), N. Shariatifar

(2), M. Bahabadi (1), A. Mohseni (3). (1) biology research center, tehran, Iran (Islamic Republic of); (2) tehran university, biology center; (3) ahvaz university reaserch center.

BARCELONAIUTOX 2010


75

P208-058THE EFFECT OF AMBLYOMIN-X ON CANCER CELL MICROENVIRONMENT AND ITS MOLECULAR TARGET ON CELL DEATH INDUCTION. A. Chudzinski-Tavassi, P. De-Sá-Júnior, S. Barreto, E. Akagi, M. Demasi, S. Simons. Laboratório de Bioquímica e Biofísica, Instituto Butantan, São Paulo, Brazil

P208-059A JUSTIFICATION MORE TO SEARCH NEW ALTERNATIVES TO LESIHMANIASIS CONTROL: TOXICITY TO MEGLUMINE ANTIMONIATE FORMULATIONS. G. Delgado

(1), Y. Sánchez (2), D. Plaza (1), A. Mariño1 (1), D. Granados1 (1). (1) Immunotoxicology Research Group. Pharmacy Department. Science Faculty. Universidad Nacional de Colombia. Bogotá, D.C, x, Colombia; (2) Interfaculty’s Pathology Lab. Pathology Department. Medicine Faculty. Universidad Nacional de Colombia. Bogotá, D.C.

P208-066NEPHROTOXICITY OF MELAMINE, CYANURIC ACID AND THE MIXTURE. L. Choi, E. Y. Han, D. E. Jang, D. H. Kim, J. S. Park, I. Y. Ahn, S. K. Lim, B. M. Lee. Sungkyunkwan University, Suwon, Korea, Republic of

P208-069INHIBITORY EFFECT OF CYP1A1 EXPRESSION BY CAPSAICIN IN HEPA-1C1C7 CELLS. E. H. Han, J. H. Im, H. G. Jeong. Chungnam National University, Daejeon, Korea, Republic of

P208-071TUBULAR ORGANIC ANION TRANSPORTER 1 AND 3 ARE RESPONSIBLE FOR THE RENAL ACCUMULATION AND NEPHROSPECIFIC TOXICITY OF ARISTOLOCHIC ACID. X. Xue, L. K. Gong, Y. Luan, X. M. Qi, Y. Li, J. Ren. Center for Drug Safety Evaluation and Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

P208-073EFFECT OF SUBACUTE CADMIUM INTOXICATION ON OXIDATIVE AND NITROSATIVE STRESS IN MICE. D. Djukic-Cosic (1), M. Ninkovic (2), Z. Malicevic (2), Z. Plamenac Bulat (1), V. Matovic (1). (1) University of Belgrade, Faculty of Pharmacy, Belgrade, Serbia; (2) Military Medical Academy.

P208-075TARGET ORGAN TOXICITY INDUCED BY VEGF INHIBITORS. A. M. Giusti, F. Marchesi, R. Pulci, A. Parazzoli, E. Giannotti, P. Colombo, M. Brughera. Accelera Srl, Nerviano, Italy

P208-076EVALUATION OF NEWLY DEVELOPED ELISAS FOR RAT, MOUSE, DOG AND PIG NGAL. K. Bangert, J. O. Eriksen, L. O. Uttenthal. BioPorto Diagnostics A/S, Gentofte, Denmark

P208-078LETHAL DILTIAZEM POISONING IN A DONKEY. A. Nowroozi Asl, M. M. Heidari, A. Rowshan Ghasrodashti. Faculty of Veterinary Medicine, Islamic Azad University , Kazerun Branch, Kazerun, Iran, Kazerun, Iran (Islamic Republic of)

P208-079COMPARISON OF TWO METHODS OF MERCURY DETERMINATION IN HAIR: HYDRIDE GENERATION ATOMIC ABSORPTION SPECTROMETRY AND ATOMIC ABSORPTION SPECTROMETRY WITH ZEEMAN BACKGROUND CORRECTION AND PYROLYSIS. L. H. Sánchez (1), E. Stashenko (2), Y. Vargas (3), J. Urrego (4). (1) Escuela de Bacteriología y Laboratorio Clínico, Universidad Industrial de Santander, Bucaramanga, Colombia;Departamento de Toxicología, Universidad Nacional de Colombia, Bogotá D.C., Colombia, x, Colombia; (2) Laboratorio de Cromatografía, Universidad Industrial de Santander, Bucaramanga, Colombia; (3) Laboratorio Químico de Consultas Industriales, Universidad Industrial de Santander, Bucaramanga, Colombia; (4) Departamento de Toxicología, Universidad Nacional de Colombia, Bogotá D.C., Colombia.

P301: COSMETICS

P301-001ALLEVIATORY EFFECTS OF CHLORELLA-DERIVED POLYPEPTIDES AGAINST UVB-INDUCED MMP-1 EXPRESSION AND EXTRACELLULAR MATRIX DEGRADATION IN HUMAN SKIN FIBROBLAST CELLS. M. F. Shih. Chia-Nan University of Pharmacy & Science, Tainan, Taiwan

P301-002A NEW ALTERNATIVE METHOD TO THE DRAIZE EYE TEST FOR THE ASSESSMENT OF THE EYE IRRITATION POTENTIAL OF CHEMICALS BY USING HCE-T CELL. S. A. Cho, S. An, H. K. Kim, T. R. Lee. Amorepacific Corporation R&D Center, Yongin-si, Korea, Republic of

P301-003ANIMAL-FREE GENOTOXICITY TESTING: THE COLIPA PROGRAM. S. Pfuhler (1), P. Carmichael (2), P. Fowler (3), R. Curren (4), C. Krul (5), G. Ouedraogo (6), K. Reisinger (7), M. Marrec-Fairley (8), A. Kirst (9), N. Hewitt (10). (1) The Procter & Gamble Co., OH, United States; (2) Unilever, Sharnbrook, United Kingdom; (3) Covance Laboratories, Harrogate, United Kingdom; (4) Institute for In Vitro Sciences, Inc, Gaithersburg, United States; (5) TNO - Quality of Life, Zeist, Netherlands; (6) L’Oréal, Aulnay-sous-Bois, France; (7) Henkel AG & Co KGaA, Duesseldorf, Germany; (8) COLIPA, Brussels, Belgium; (9) KPSS-Kao Professional Salon Services, Darmstadt, Germany; (10) Scientific Writing Services

P301-004ANALYSIS OF RETINOIDS AND CORTICOSTEROIDS IN LIGHTENING COSMETICS AND THEIR POSSIBLE INVOLVEMENT IN THE CUTANEOUS LESIONS DEVELOPED BY SAHARAWI WOMEN. M. C. Pellín (1), J. Esteban (1), C. Pereda (2), J. Barril (1), C. Gimeno (3). (1) Universidad Miguel Hernandez de Elche, Elche, Spain; (2) Hospital de los Arcos. Santiago de la Rivera (Murcia); (3) UCA de La Vila Joiosa Departamento 16 (Alicante).

P302: DRUGS DEVELOPMENT

P302-001EXTRACTION AND CHARACTERIZATION OF THE BACTERIAL SURFACE COMPONENTS FROM VIBRIO CHOLERAE USING ZWITERIONIONIC, NON-IONIC AND ANIONIC DETERGENTS. M. Pérez Navarro (1), B. Tamargo (2), T. Bui Thanh (2), O. Otero (3), G. Falero (3), J. Pérez (3), G. Sierra (3). (1) Institute of Pharmacy and Food, University of Havana, San Juan y Martínez, Cuba; (2) Pharmacy and Foods Institute, University of Havana; (3) Finlay Institute; Center of Investigation, Development and Production of Serums and Vaccine,

P302-002THE USE OF POSITIVE REINFORCEMENT IN GÖTTINGEN MINIPIGS. P. Glerup (1), D. Bratbo (2), S. Mølgaard (1), L. Andersen (1). (1) LAB Research (Scantox), Lille Skensved, Denmark; (2) University of Copenhagen,


76

P302-003IN VITRO AND DERMAL TOXICITY STUDIES FOR HIPPOPHAE RHAMNOIDES L. LEAF EXTRACT. N. Upadhyay (1), A. Gupta (2). (1) Department of Biochemical Pharmacology, Defence Institute of Physiology and Allied Science, Delhi-110054, India & Department of Toxicology, Hamdard University, Delhi-110062, India., (2) Department of Biochemical Pharmacology, Defence Institute of Physiology and Allied Sciences, Delhi-110054, India.

P302-004COMPARISON OF THE EFFECT OF VITE AND ( VITE_SELENIUM)ONTISSUEOXIDATION IN CAT NEPHROTOXICITY. S. Moshfeghi. Islamic Azad University Of Garmsar, Iran

P302-005ANDROGEN ALTER MITOSIS ORIENTATION IN THE PROSTATE EPITHELIA CELLS. X. Y. Liu, Z. Y. Sun. Shanghai Institute of Planned Parenthood Research, Shanghai, China

P302-006TOXICOLOGY AND SAFETY OF THE 4-HIDROXI-3-METOXIBENZALDEHÍDO: ACUTE, SUBCHRONIC AND REPRODUCTIVE TOXICITY STUDIES. Y. M. Trapero Quintana

(1), A. Mancebo Rodriguez (2), Y. Gonzales Torres (2), M. A. Torres Aleman (2), J. F. Infante (2), M. Durruthy (2), A. Curbelo Valiente (2), Y. Prado (2), A. Remigio Montero (2). (1) Centro de Biofísica Médica, Universidad de Oriente., Santiago de Cuba, Cuba; (2) , Cuba

P302-007DESIGN AND ONE-POT SYNTHESIS OF A-AMINOPHOSPHONATES AND BIS(A-AMINOPHOSPHONATES) BY IRON(III) CHLORIDE AND CYTOTOXIC ACTIVITY. Z. Rezaei (1), H. Firouzabadi (2), N. Iranpour (2), A. Ghaderi (2), M. R. Jafari (1), A. A. Jafari (2). (1) Faculty of Pharmacy, Shiraz, Iran (Islamic Republic of); (2) ,

P302-008IN SILICO PREDICTION OF IN VIVO TOXICITY - THE FIRST STEPS OF THE E-TOX CONSORTIUM. T. Steger-Hartmann (1), F. Pognan (2), F. Sanz (3), C. Diaz (3), A. Sutter (1), M. Pastor (3). (1) Bayer Healthcare, Berlin, Germany; (2) Novartis, Basel, Switzerland; (3) IMIM, Barcelona, Spain

P302-009ANALGESIC EFFECT OF CALENDULA OFFICINALIS FLOWERS EXTRACT IN MICE. N. Behtash (1), H. Shafaroudi (1), Z. Nazari Khorasgani (2). (1) Tehran Azad University of Medical Sciences, Tehran, Islamic republic of Iran, Tehran, Iran (Islamic Republic of); (2) Ahvaz jondishapour University of Medical Sciences, Islamic republic of Iran,

P302-010EFFECT OF HYDROPHILIC EXIPIANT ON DRUG RELEASE FROM ETHYLCELLULOSE AND HYDROXYPROPYL METHYLCELLULOSE FILMS CONTAINING LIDOCAIN AND PRILOCAIN. M. Kouchak, S. Rezae, N. Moshabeh. Dept. of Pharmaceutics, Pharmacy school, Ahvaz Jundishapur University of Medical Sciences,

P302-011ANTIDOTAL EFFICACY OF BISPYRIDINIUM OXIMES AGAINST NERVE AGENTS. B. Radic (1), S. Berend (1), A. Lucic Vrdoljak (1), D. Kukin (2), N. Fuchs (3), K. Kuca (4). (1) Institute for medical research and occupational health, Zagreb, Croatia (Hrvatska); (2) University Hospital Center Rebro, ; (3) Clinical Hospital ˝Sestre milosrdnice˝; (4) Faculty of Military Health Sciences, University of Defense,

P302-012IN VITRO ABSORPTION OF 4(1H)-PYRIDONE ANTIMALARIAL DERIVATIVE AND ITS PRO-DRUG USING A CACO-2 MODEL. M. J. Almela, P. A. Torres, S. Lozano, J. M. Bueno, S. Huss, J. L. Lavandera, J. F. García Bustos, E. Herreros. GlaxoSmithKline R&D / Tres Cantos Medicines Development Campus, Tres Cantos, Spain

P302-013FEASIBILITY OF MONITORING GASTROINTESTINAL FUNCTION IN THE DOG USING A WIRELESS MULTISENSOR TELEMETRY CAPSULE. S. Milano (1), J. P. Briffaux (1), S. Baudet (1), P. Legé (1), C. Dupuis (1), J. Semler (2), B. Rohde (2), E. Chalencon (1). (1) MDS Pharma Services, Lyon, France, Saint Germain sur l’Arbresle, France; (2) SmartPill Corporation, Buffalo, NY, USA, , United States

P302-014RENAL TOXICITY IN DOGS ASSOCIATED WITH THE MALEATE SALT, NOT WITH THE TOSYLATE SALT OF TC-5619. J. Xie, S. Toler. Targacept Inc, Winston Salem, United States

P302-015TELEMETRY STUDIES IN THE MINIPIG WITH REFERENCE DRUGS. S. Loriot, A. M. Bétat, R. Forster, A. Simonnard. CIT, Evreux, France

P302-016CYTOCHROME C RELEASE AND CASPASES ACTIVATION IN CELLS TREATED WITH 4(1H)-PYRIDONE ANTIMALARIAL DERIVATIVES. S. Lozano, M. J. Almela, P. A. Torres, J. Lelievre, J. F. García Bustos, E. Herreros. GlaxoSmithKline R&D / Tres Cantos Medicines Development Campus, Tres Cantos, Spain

P302-017LEFT VENTRICULAR PRESSURE MEASUREMENT IN THE TELEMETERED DOG. A. Simonnard, A. M. Bétat, S. Loriot, R. Forster. CIT, Evreux, France

P302-018BIO-ACTIVE RESOURCES FROM MACROFUNGI OF NORTHERN NIGERIA. U. A. Katsayal, M. S. Abubakar. Ahmadu Bello University, Zaria, Nigeria

P302-019CHARACTERIZING THE THERAPEUTIC EFFICACY OF NOVEL OXIMES SYNTHESIZED BY CLICK CHEMISTRY AGAINST ORGANOPHOSPHOROUS COMPOUNDS POISONING. S. Berend (1), A. Lucic Vrdoljak (1), B. Radic (1), J. Kalisiak (2), Z. Radic (3), P. Taylor (3), V. V. Fokin (2), K. B. Sharpless (2). (1) Institute for medical research and occupational health, Zagreb, Croatia (Hrvatska); (2) The Scripps Research Institute, La Jolla, CA: (3) UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, CA,

P302-020A CARDIOTOXICITY PREDICTION SYSTEM BASED ON MULTISCALE MODELING. C. Obiol-Pardo (1), J. Gomis-Tena (2), J. Saiz (2), M. Pastor (1), F. Sanz (1). (1) Parc Recerca Biomedica Barcelona (PRBB), Barcelona, Spain; (2) Universitat Politecnica Valencia, Valencia, Spain

P302-021THE ANTIANGIOGENIC AND ANTITUMOR ACTIVITY OF BETULINIC ACID DISSOLVED WITH RAMIFIED GAMMA-TYPE CYCLODEXTRIN. S. Feflea, C. Tiulea, S. A. Ciurlea, C. Soica, C. Peev, C. A. Dehelean. University of Medicine and Pharmacy Victor Babes Timisoara, Timisoara, Romania

P302-022COMPARISON OF CYTOTOXICITY AND GENOTOXICITY OF HI-6 OXIME FOR DIFFERENT HUMAN AND RODENT CELL LINES. H. Svobodova, P. Jost, R. Stetina. Faculty of Military Health Sciences, University of Defence, Hradec Králove, Czech Republic

BARCELONAIUTOX 2010


77

P302-023INHIBITION OF PROTEIN GERANYLATION UNDERLIES THE ANTIPROLIFERATIVE EFFECT OF FLUVASTATIN IN MDA-MB-231 AND 3LL CELLS. R. Nunez-Lozano (1), F. J. López-Hernández (2), J. M. López-Novoa (1), A. I. Morales (1). (1) Universidad de Salamanca, Salamanca, Spain; (2) Hospital Universitario de Salamanca

P302-024MDMA (DRUG)-DRUG INTERACTIONS INFLUENCE CYP3A4 EXPRESSION VIA PXR- MEDIATOR. I. Antolino Lobo (1), R. Maas-Bakker (2), I. Meijerman (2), J. Meulenbelt (3), M. Van Den Berg (1), M. Van Duursen (1). (1) Institute for Risk Assessment Sciences (IRAS), Utrecht, Netherlands; (2) Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands, Utrecht, Netherlands; (3) National Poisons Information Centre, National Institute for Public Health and the Environment, Utrecht,

P302-025IN VIVO OXIME REACTIVATION OF CHOLINESTERASE ACTIVITY IN TABUN POISONED RATS. Z. Kovarik, N. Maček, M. Katalinić. Institute for Medical Research and Occupational Health, Zagreb, Croatia (Hrvatska)

P302-026BILASTINE. PRECLINICAL TOXICOLOGY REVIEW. J. Arteche (1), F. Ledo (1), A. Casadesus (2), L. Canut (2), F. Gomez (2), A. Tortajada (2), M. L. Lucero (1). (1) Faes Farma S.A, Spain (2) Harlan Laboratories Ltd., Spain

P302-027OXIDATIVE STRESS DURING SOMAN INTOXICATION AND TREATMENT WITH ATROPINE, ASOXIME, TRIMEDOXIME AND K203 IN A RAT MODEL. M. Pohanka (1), M. Mercova (2), J. Z. Karasova (1), K. Kuca (1), J. Pikula (3), J. Kassa (1). (1) Faculty of Military Health Sciences, University of Defense, Hradec Kralove, Czech Republic, Hradec Kralove, Czech Republic; (2) Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic, (3) Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic,

P302-028TOXICOLOGIC PROFILE OF A SEMIPURE LECTIN FRACTION FROM TEPARY BEAN ADMINISTRATED VIA ORAL: IN FOCUS OF ITS ANTICANCER EFFECT. T. Garcia-Gasca (1), A. J. Rodiguez-Mendez (2), R. Ferriz-Martinez (1), C. Lopez-Sanchez (1), K. Garcia-Garcia (1), A. Herrera-Diaz (2), M. Padilla-Lopez (2), P. Resendiz-Melgoza (2), M. A. Gallegos-Corona (2), O. P. Garcia-Obregon (1), A. Blanco-Labra (3). (1) Facultad De Ciencias Naturales. Universidad Autonoma De Queretaro.,Mexico (2) Facultad De Medicina. Universidad Autonoma De Queretaro,Mexico (3) Cinvestav-Ipn Unidad Irapuato, Mexico

P302-029EVALUATION OF CUTANEOUS TOXICITY BY A LATEX PROTEOLYTIC FRACTION FROM CARICA CANDAMARCENSIS. F. Lemos, M. I. Villalba, C. Tagliati, G. Cassali, C. Salas, M. Lopes. Federal University of Minas Gerais, Contagem, Brazil

P302-030ARYL HYDROCARBON RECEPTOR INDUCTION BY ALPHA- AND SS-PIFITHRIN. M. L. Fernández-Cruz (1), A. Valdehita (1), M. Alonso (2), E. Mann (2), B. Herradón (2), J. M. Navas (1). (1) INIA, Madrid, Spain; (2) IQOG, CSIC, Madrid, Spain

P302-031ORAL SUBCHRONIC TOXICITY EVALUATION OF A LATEX PROTEOLYTIC FRACTION FROM CARICA CANDAMARCENSIS. C. Salas, M. I. Villalba, V. Mello, R. Bilheiro, G. Cassali, C. Tagliati, M. Lopes, M. Martínez-Larrañaga, A. Anadon. Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

P302-032THE EFFECT OF NEW ASPIRIN PRODRUGS ON BLOOD PLATELET AND TUMOR CELLS IN AN ‘IN VITRO’ STUDY. I. Inkielewicz-Stepniak (1), J. Gilmer (2), M. Radomski (2), C. Medina (3). M. Woźniak(1) (1) Medical University, Gdansk, Poland. (2) School of Pharmacy and Pharmaceutical Science, Trinity College, Dublin, Ireland (1) Medical University, Gdansk, Poland (2) School of Pharmacy and Pharmaceutical Science, Trinity College, Dublin, Ireland

P302-033THE STUDY OF ANALGESIC EFFECT OF HYDROALCOHOLIC EXTRCT OF TEUCRIUM OLIVERANUM IN RAT BY FORMALIN TEST. A. Arzi, F. Arzi, E. M. Arzi. School of Pharmacy, physiology research center, Ahwaz Jundishapur Univesity if Medical Sciences, Ahwaz, Iran, Ahwaz, Iran (Islamic Republic of)

P302-034FK-3000 ISOLATED FROM STEPHANIA DELAVAYI DIELS. INHIBITS BREAST CANCER CELL PROLIFERATION BY SUPPRESSING NF-ƒÛB AND COX-2. M. J. Lee (1), S. S. Han (2). (1) Kangwon National University, Chunchen, Korea, Republic of; (2) Hoseo University, Asan, Korea, Republic of

P302-035PRECLINICAL TOXICITY EVALUATION OF SYNGONANTHUS MACROLEPSIS CRUDE EXTRACT WITH ANTIMICOBACTERIA ACTIVITY. G. Honorato De Oliveira, V. Pereira Arantes. School of Pharmaceutical Sciences Sao Paulo State University UNESP, Araraquara, Brazil

P302-036A STUDY ON THE FACTORS AFFECTING THE COMPRESSIBILITY OF GREEN TEA LEAVES POWDER TO MAKE A NONTOXIC HERBAL TABLET. A. Moghbel. Ahvaz Jundishapur University of Medical Sciences., Ahvaz, Iran (Islamic Republic of)

P302-037GONIOTHALAMIN INDUCES MITOCHONDRIA-MEDIATED APOPTOSIS VIA P53-DEPENDENT CASPASE-2 ACTIVATION PATHWAY IN CORONARY ARTERY SMOOTH MUSCLE CELLS. K. M. Chan (1), N. F. Rajab (1), D. Ross (2), S. H. Inayat-Hussain (1). (1) Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; (2) University of Colorado Denver,

P302-038EFFECT OBSERVED AFTER 28 DAYS NASAL DOSING OF ERYTHROPOIETIN WITH A LOW CONTENT OF SIALIC ACID. A. Lagarto, V. Bueno, M. Couret, O. Valdes, R. Lopez, I. Guerra, T. Gabilondo, Y. Vega. CIDEM, Havana, Cuba

P302-039ANTIBACTERIAL ACTIVITY OF THE ENNIATINS A, A1, B, B1 PRODUCED BY FUSARIUM TRICINCTUM IN LIQUID CULTURE, AND CYTOTOXICITY EFFECTS ON CACO-2 CELLS. M. J. Ruiz, G. Meca, J. Mañes, G. Font. Faculty of Pharmacy/University of Valencia, Burjassot, Spain

P302-040ADME/TOX DATA SET INTEGRATION FOR TRASLATIONAL PREDICTION OF NON CLINICAL ASSAYS. MELIUS PROJECT. F. Ledo, J. Arteche, M. Nuñez, M. Lucero. FAES FARMA S.A., LEIOA, Spain

P302-041MODIFYING EFFECT OF LAC COLOR AND COCHINEAL EXTRACT ON THE DEVELOPMENT OF CAPSULAR INVASIVE CARCINOMAS INDUCED BY PROMOTION WITH SULFADIMETHOXINE IN A RAT TWO-STAGE THYROID CARCINOGENESIS MODEL. S. Kemmochi, L. Wang, K. Shimamoto, E. Taniai, H. Hayashi, K. Mitsumori, M. Shibutani. Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan


78

P302-042IMPLEMENTATION OF ETS 123 REQUIREMENTS FOR THE HOUSING OF MARMOSET MONKEYS (CALLITHRIX JACCHUS) OVER THE CONDUCT OF REGULATORY REQUIRED TOXICITY STUDIES. S. Korte, W. Müller, U. Zühlke. Covance Laboratories GmbH, Münster, Germany

P302-043EVALUATION OF METABOLIC EFFECTS OF TWO TRITERPENIC DERIVATES OBTAINED FROM SALVIA SP. ON ENDOTHELIAL PRIMARY CELL CULTURE HUVEC. M. Constantinovici, L. Zglimbea, N. Dociu, A. Netoiu, L. Olariu. Biotehnos, Otopeni, Romania

P302-044ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY – HIGH DEFINITION MASS SPECTROMETRTY (UPLC™-HDMS™) AS A USEFUL TOOL IN PREDICTIVE DRUG TOXICOLOGY. AN ACTIVITY OF MELIUS PROYECT. J. Barr (1), M. Vazquez-Chantada (1), C. Alonso (1), A. Castro (1), N. Fabre (2), J. A. Vericat (2). (1) OWL Genomics, Derio, Spain; (2) Noscira S.A., Madrid, Spain

P302-045METABOLOMIC MODELLING OF DRUG TOXICITY. AN ACTIVITY OF THE MELIUS PROJECT. M. Vazquez-Chantada (1), J. Barr (1), C. Alonso (1), A. Castro (1), N. Fabre (2), J. A. Vericat (2). (1) OWL Genomics, Derio, Spain; (2) Noscira S.A., Madrid, Spain

P302-046IDENTIFICATION OF GENE EXPRESSION EFFECTS BY DNA MICROARRAYS AFTER TREATMENT OF CYNOMOLGUS MONKEYS WITH A NEW CANDIDATE DRUG. AN ACTIVITY OF MELIUS PROYECT. L. Osaba (1), D. Fernández (1), E. Entrena (1), I. Calahorro (1), N. Fabre (2),J. A. Vericat(2). (1) Progenika Biopharma, S. A., Derio, Spain; (2) Noscira S.A., Tres Cantos, Spain

P302-047EVALUATION OF THE IN VITRO CYTOTOXICITY OF NS-A ON ANIMAL AND HUMAN CELL CULTURES. AN ACTIVITY OF THE MELIUS PROJECT. C. Aristimuño (1), G. Aperribai (1), A. Aspiazu (1), A. Alejandro (1), I. Anglade (2), N. Fabre (2), J. A. Vericat (2). (1) GAIKER Technological Center, zamudio, Spain; (2) Noscira, S.A., Tres Cantos, Spain

P302-048DATA-MINING AS AN APPROACH TO FIND HIDDEN DATA IN TOXICITY STUDIES. AN ACTIVITY OF THE MELIUS PROJECT. M. Pastor (1), F. Sanz (1), T. Nadal (2), N. Fabre

(2), J. A. Vericat (2). (1) FIMIM-UPF, Barcelona, Spain; (2) Noscira S.A., Tres Cantos, Spain

P302-049STUDY USING DIFFERENTIAL GENE EXPRESSION ANALYSIS OF THE DIFFERENT TOXIC RESPONSES IN MALE AND FEMALE RATS AFTER TREATMENT WITH AN ANTICHOLINESTERASIC DRUG CANDIDATE. AN ACTIVITY OF THE MELIUS PROJECT. A. Garcia (1), Z. Ispizua (1), M. Betanzos (1), B. Suarez (1), I. Anglade (2), N. Fabre (2), J. A. Vericat (2). (1) GAIKER, Zamudio, Spain; (2) NOSCIRA S.A, Madrid, Spain

P302-050EVALUATION OF THE IN VITRO CYTOTOXICITY OF NP061017, NP061034 AND NP060136 ON ANIMAL AND HUMAN CELL CULTURES. AN ACTIVITY OF THE MELIUS PROJECT. C. Aristimuño (1), G. Aperribai (1), A. Aspiazu (1), A. Alejandro (1), I. Anglade (2), N. Fabre (2), J. A. Vericat (2). (1) GAIKER Technological Center, Zamudio, Spain; (2) Noscira, S. A., Tres Cantos, Spain

P302-051STUDY USING DIFFERENTIAL GENE EXPRESSION ANALYSIS OF THE TOXIC RESPONSES IN BLADDER FROM MALE AND FEMALE DOGS AFTER TREATMENT WITH A NEW ANTICHOLINESTERASIC COMPOUND FOR 28 DAYS. AN ACTIVITY OF THE MELIUS PROJECT. A. García (1), I. Amann (1), M. Betanzos (1), N. Fabre (2), I. Anglade (2), J. A. Vericat (2). (1) GAIKER Technological Center, zamudio, Spain; (2) Noscira, S.A., Tres Cantos, Spain

P302-052STUDY USING DIFFERENTIAL GENE EXPRESSION ANALYSIS OF THE DIFFERENT TOXIC RESPONSES IN MALE AND FEMALE DOGS AFTER TREATMENT WITH ANTICHOLINESTERASIC COMPOUND FOR 13 WEEKS. AN ACTIVITY OF THE MELIUS PROJECT. M. Betanzos (1), A. Garcia (1), B. Suarez (1), I. Amann (1), N. Fabre (2), I. Anglade (2), J. A. Vericat (2). (1) GAIKER Technological Center, Zamudio, Spain; (2) NOSCIRA S.A, Tres Cantos, Spain

P302-053IS SEX A MAJOR DETERMINANT OF DIFFERENTIAL TOXICITY IN THE LIVER OF INDIVIDUALS TREATED WITH A NEW ANTICHOLINESTERASIC COMPOUND? AN ACTIVITY OF THE MELIUS PROJECT. L. Gombau (1), J. V. Castell (2), I. Anglade (3), T. Nadal (4), N. Rivas (4), N. Fabre (4), J. A. Vericat (4). (1) ADVANCELL, Valencia, Spain; (2) 1Fundación La Fe & Advancell, Valencia, Spain; (3) 2Noscira S.A., Tres Cantos (Madrid), Spain; (4) Noscira S.A., Tres Cantos (Madrid), Spain

P302-054NYPTA (NP031112) DOES NOT POSSESS MUTAGENIC POTENTIAL. AN ACTIVITY OF THE MELIUS PROJECT. N. Fabre, T. Nadal, J. A. Vericat. Noscira SA, Tres Cantos, Spain

P302-055THE MELIUS PROJECT: A SPANISH INDUSTRIAL PROJECT TO IMPROVE THE TRASLATIONAL PREDICTION OF THE NON-CLINICAL SAFETY STUDIES TO MAN. J. A. Vericat (1), P. Avilés (2), A. Castro (3), C. Eibe (4), D. Fernández (5), M. Guardia (6), F. Ledo (7), L. Osaba (8), M. Rey (9). (1) Noscira, S.A., Tres Cantos, Spain; (2) Pharmamar, S.A.U., Colmenar Viejo, Spain; (3) OWL Genomicsw S.L., Derio, Spain; (4) Zeltia, S.A., Madrid, Spain; (5) Proteomika, S.L., Derio, Spain (6) Laboratorios Farmacéuticos Rovi, S.A., Madrid, Spain; (7)

FAES Farma, S.A., Leioa, Spain (8) Progenika Biopharma, S.A., Derio, Spain; (9) Newbiotechnic, S.A., Sevilla, Spain

P302-056TOXIC EFFECTS ASSOCIATED TO THE USE OF THE DELIVERY ENHANCER CAPRYLOCAPROYL MACROGOL-8 GLYCERIDE (LABRASOL) IN EARLY TOXICOLOGICAL STUDIES IN RATS. AN ACTIVITY OF THE MELIUS PROJECT. Y. Saavedra, J. Benito, F. Cabello, G. Nejar, V. Martinez, P. Vergara, J. Cantó.. Universidad Autónoma de Barcelona, Bellaterra, Spain

P302-057SEX-RELATED ACUTE TOXICOLOGICAL EFFECTS OF NS-B IN RATS. AN ACTIVITY OF THE MELIUS PROJECT. F. Cabello (1), J. Benito (1), Y. Saavedra (1), G. Nejar (1), N. Fabre (2), I. Anglade (2), J. A. Vericat (2), V. Martinez (1), J. Cantó (1), P. Vergara (1). (1) Universidad Autónoma de Barcelona, Bellaterra, Spain; (2) Noscira, Madrid,

P302-058CHARACTERIZATION OF EXACERBATED ANTICHOLINESTERASIC-RELATED PHARMACOLOGICAL EFFECTS IN FEMALE RATS TREATED WITH NP0361. AN ACTIVITY OF THE MELIUS PROJECT. J. Benito (1), S. Barbosa (1), F. Cabello (1), P. Vergara (1), N. Fabre (2), T. Nadal (2), J. A. Vericat (2), O. Martinez Montero (2), M. Perez De La Cruz Moreno (2), J. Cantó (1), V. Martinez (1). (1) Universidad Autónoma de Barcelona, Bellaterra, Spain; (2) Noscira, Madrid,

P302-059EVALUATION OF THE EFFECT OF A DRUG CANDIDATE ON GLUTATHIONE CONTENT IN PRIMARY HEPATOCYTES IN CULTURE. AN ACTIVITY OF THE MELIUS PROJECT. C. J. Rodriguez-Hernandez (1), J. J. Guinovart (1), N. Fabre (2), J. A. Vericat (2). (1) Institute for Research in Biomedicine, Barcelona, Spain; (2) Noscira, S.A.,

BARCELONAIUTOX 2010


79

P302-060ANALYSIS BY TWO DIMENSIONAL ELECTROPHORESIS OF PROTEIN EXPRESSION IN LIVER OF RATS TREATED WITH AN ANTICHOLINESTERASIC COMPOUND. M. Conde (1), D. Fernandez (1), D. Nagore (1), L. Simon (1), I. Anglade (2), N. Fabre (2), J. A. Vericat (2). (1) Proteomika S.L, Derio, Spain; (2) NOSCIRA SA, TRES CANTOS, Spain

P302-061ASSESSMENT OF THE INHIBITION ON MAJOR HUMAN CYP450 ISOFORMS AS A PREDICTOR OF PUTATIVE INTERACTION ON CONCOMITANTLY ADMINISTERED DRUGS FOR A NEW COMPOUND UNDER DEVELOPMENT. AN ACTIVITY OF THE MELIUS PROJECT. L. Gombau (1), A. Aranda (2), L. Sequedo (2), L. Picazo (2), G. Quintas (1), J. V. Castell (2), J. A. Vericat (3), N. Fabre (3). (1) ADVANCELL. Advanced In Vitro Cell Technologies S.A, VALENCIA, Spain; (2) Unidad de Hepatología Experimental, Centro de Investigación Hospital Universitario La Fe, Spain; (3) Noscira S.A.,

P302-062INTEGRATION OF -OMICS DATA FOR EVALUATING HEPATOTOXIC RESPONSE OF MONKEYS TREATED WITH A COMPOUND UNDER DEVELOPMENT. AN ACTIVITY OF MELIUS PROJECT. D. Fernández-Orth (1), L. Osaba (1), M. Conde (2), D. Fernández (2), D. Nagore (2), J. Barr (3), M. Vazquez-Chantada (3), A. Castro (3), N. Fabre (4), J. A. Vericat (4). (1) Progenika Biopharma S.A., Derio, Spain; (2) Proteomika S.L., Derio, Spain; (3) Owl Genomics, Derio, Spain; (4) Noscira S.A., Tres Cantos, Spain

P302-063METABOLIC CHARACTERIZATION OF PB60 AND PB65, TWO PEPTIDOMIMETICS WHICH NOTABLY FACILITATE THE TRANSPORT OF HEPARIN ACROSS THE INTESTINAL BARRIER. AN ACTIVITY OF THE MELIUS PROJECT. G. Quintas (1), A. Aranda (2), L. Sequedo (2), L. Picazo (2), M. Garcia-Amo (3), J. V. Castell (2), L. Gombau (1). (1)

ADVANCELL S.A, Spain (2) Hospital La Fe,Spain (3) Laboratorios Farmacéuticos Rovi S.A.Spain

P302-064ONE YEAR ORAL TOXICITY OF D-004, A LIPID EXTRACT FROM ROYSTONEA REGIA FRUITS, IN SPRAGUE DAWLEY RATS. R. Gámez, A. Gutiérrez, D. F. Arencibia, B. Pardo, M. Noa, R. Más, M. Valle, Á. Oyárzabal, D. Curveco, H. García, E. Goicochea, N. Mendoza, S. Jiménez. Center of Natural Products, Havana City, Cuba

P302-065A STRATEGY FOR EXTENDING THE RANGE OF IN VITRO HEPATOTOXICITY ASSESSMENT OF TEST COMPOUNDS WITH LOW TOXIC POTENCY. AN ACTIVITY OF THE MELIUS PROJECT. L. Díaz (1), L. Gumbau (2), D. Sequedo (2), G. Herrera (1), J. E. O’connor (1), N. Fabre (3), J. A. Vericat (3). (1) Centro de Investigación Príncipe Felipe, Valencia, Spain; (2) Advancell, S.A., Valencia, Spain; (3) Noscira, S.A.,

P302-066NOVEL MINIATURIZED EX-VIVO ASSAY OF CYTOKINE SECRETION FOR DETECTION AT REMOTE LABORATORY OF DRUG-INDUCED IMMUNE ALTERATIONS IN NON-HUMAN PRIMATES. AN ACTIVITY OF THE MELIUS PROJECT. L. Díaz (1), G. Herrera (1), J. P. Briffaux (2), J. E. O’connor (1). (1) Centro de Investigación Príncipe Felipe, Valencia, Spain; (2) MDS Pharma Services,

P302-067AN INTEGRATED PLATFORM OF CYTOMIC IN VITRO ASSAYS FOR MULTIPARAMETRIC PROFILING OF TOXICITY MECHANISMS IN DRUG DISCOVERY AND PRECLINICAL SAFETY. AN ACTIVITY OF THE MELIUS PROJECT. G. Herrera (1), L. Díaz (1), C. Navarro (1), N. Fabre (2), J. A. Vericat (2), J. E. O’connor (1). (1) Centro de Investigación Príncipe Felipe, Valencia, Spain; (2) Noscira, S.A.,

P302-068STUDY OF THE DIFFERENT TOXIC RESPONSES IN MALE AND FEMALE RATS AFTER TREATMENT WITH NEW ANTICHOLINESTERASIC DRUG THROUGH GENOMIC AND PROTEOMIC TOOLS. AN ACTIVITY OF THE MELIUS PROJECT. M. Betanzos (1), A. García (1), Z. Ispizua (1), B. Suarez (1), M. Conde (2), D. Fernández (2), D. Nagore (2), L. Simón (2), N. Fabre (3), J. A. Vericat (3). (1) GAIKER Technological Center, Zamudio, Spain; (2) Proteomika S.L,

P302-069THE OXIME PRO-2-PAM PROVIDES MINIMAL PROTECTION AGAINST THE CNS EFFECTS OF THE ORGANOPHOSPHORUS NERVE AGENTS SARIN, CYCLOSARIN, AND VX IN GUINEA PIGS. T. M. Shih, J. A. Guarisco, I. Koplovitz, R. K. Kan, T. M. Myers, J. H. Mcdonough. US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, United States

P302-071HYPOGLYCEMIC AND HYPOLIPIDAEMIC ACTION OF BITTER MELON ON NORMOGLYCEMIC AND HYPERGLYCEMIC DIABETIC RATS. A. Abdullah, S. Bakry, A. Abd El-Baky. Biochemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, Egypt

P302-072EFFECT OF DEPOT MEDROXYPROGESTERONE (DMPA) ON SERUM PROTEINS AND LIPID PROFILE IN MICE. A. Hassan, S. Bakry, A. Abdullah, M. Shahat. Center for Genetic Engineering, Al Azhar University., Nasr City, Egypt

P302-073HISTOMORPHOMETRICAL STUDY OF SEMINIFEROUS TUBULE IN RATS AFTER USED TRIBULUS TERRESTERIS. A. Esfandiari. Islamic Azad University, Kazerun Branch, kazerun, Iran (Islamic Republic of)

P302-076ANTI-INFLAMMATORY EVALUATION AND MECHANISMS OF EUGENOL AND ISOEUGENOL DERIVATIVES IN LIPOPOLYSACCHARIDE-STIMULATED MACROPHAGES. S. F. Liou (1), Y. S. Hong (2), C. L. Chen (1), Y. W. Liu (2), J. L. Yeh (2). (1) Chia-Nan University of Pharmacy and Science, Tainan, Taiwan; (2) College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

P302-077STEREOLOGICAL STUDY OF METHIMAZOLE-INDUCED ADRENAL GLAND ATROPHY. F. Dehghani, N. Ali, M. Panjehshahin, S. Karbalay-Doust. Shiraz University Of Medical Sciences, Shiraz, Iran (Islamic Republic of)

P303: NANOTOXICOLOGY

P303-001DE NOVO TOXICOLOGICAL STUDY OF MULTI-WALLED CARBON NANOTUBES USING PROTEOMIC APPROACH. H. Haniu (1), Y. Matsuda (2), Y. Usui (1), K. Aoki (1), N. Ogihara (1), M. Shimizu (1), K. Hara (1), N. Ishigaki (1), K. Nakamura (1), N. Saito (1), M. Endo (1). (1) Shinshu University, Matsumoto, Japan; (2) Nihon Pharmaceutical University,

P303-002UPTAKE AND EFFECTS OF CARBON NANOTUBES IN BRONCHIAL EPITHELIAL CELLS. S. Hirano, A. Furuyama, Y. Fujitani. National Institute for Environmental Studies, Tsukuba, Japan


80

P303-003SETTING UP OF A NEW MICROFLUIDIC IN-VITRO TEST SYSTEM FOR CONNECTED CULTURE FOR TOXICOLOGY TESTING. N. Ucciferri (1), T. Sbrana (1), C. Domenici (2), A. Ahluwalia (1). (1) University of Pisa, Pisa, Italy; (2) CNR Istitute of Clinical Physiology,

P303-004PULMONARY RESPONSES TO MULTI-WALL CARBON NANOTUBES AFTER SINGLE INTRATRACHEAL INSTILLATION IN RATS. M. Naya, N. Kobayashi, M. Ema, J. Nakanishi. National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan

P303-005SIO2 NANOPARTICLES INDUCE CYTOTOXICITY AND PROTEIN EXPRESSION ALTERATION IN HACAT CELLS. X. Yang (1), J. Liu (1), H. He (1), X. Wang (2), Z. Zhuang (1). (1) Shenzhen Centre for Disease Control and Prevention, Shenzhen, China; (2) Department of Biochemistry and Molecular Biology, Life Science School, Shenzhen University, Shenzhen, CHINA,

P303-006WHAT EFFECTS HAVE ULTRAFINE PARTICLE IN THE VASCULAR SYSTEM? A PROTEOMIC STUDY ON HUMAN ENDOTHELIAL CELLS. M. Pink, A. W. Rettenmeier, S. Schmitz-Spanke. Institute for Hygiene and Occupational Medicine, University Essen, Essen, Germany

P303-007TOXICITY OF DEGRADED TITANIUM AND CERIUM OXIDES NANOPARTICLES TOWARDS AN INTESTINAL CELL MODEL. M. Fisichella, O. Prat. CEA, Bagnols-sur-Cèze, France

P303-008EVALUATION OF ACUTE DERMAL TOXICITY OF COMPONENTS OF NANOSTRUCTURED SYSTEMS. H. Rocha E Silva, G. Marielli Da Luz, B. C. Correa, M. P. Daflon Gremião, G. Honorato De Oliveira. Pharmaceutical Sciences School of UNESP Araraquara, Brazil, ARARAQUARA, Brazil

P303-009PROFILING OF OXIDATIVE DAMAGE POTENTIAL OF CUO, ZNO AND AG NANOPARTICLES USING RECOMBINANT LUMINESCENT BACTERIAL SENSORS AND SUPEROXIDE DISMUTASE DEFECTIVE STRAINS. O. Bondarenko, A. Ivask, N. Jepihhina, A. Kahru. National Institute of Chemical Physics and Biophyiscs, Tallinn, Estonia

P303-010POLYMERIC NANOPARTICLE MEDIATED CYTOTOXICITY IN TWO CELL LINES. P. Heredia (1), F. Goñi De Cerio (1), J. Thevenot (2), E. Garanger (2), C. Aristimuño (1), A. Aspiazu (1), N. Puente (1), S. Lecommandoux (2). (1) GAIKER Technological Center, Zamudio, Spain; (2) University of Bordeaux, Laboratoire de Chimie des Polymères Organiques (UMR CNRS 5629), ENSCBP-IPB,

P303-011THE ADSORPTION OF PROTEINS WITH DIFFERENT ISOELECTRIC POINTS TO CHITOSAN NANOPARTICLES. J. Lee (1), S. Ko (2), H. Kwon (3). (1) Department of Food and Nutrition, Seoul National University, Seoul, Korea, Republic of, Seoul, Korea, Republic of; (2) Department of Food Science and Technology, Sejong University, Seoul, Korea, Republic of, ; (3) Department of Food and Nutrition, and Research Institute of Human Ecology, Seoul National University, Seoul, Korea, Republic of,

P303-012SAFETY EVALUATION OF NANOMATERIALS USED IN HOUSEHOLD PRODUCTS. A. Matsuoka, Y. Kodama, M. Yoshida, K. Isama, F. Nakajima, K. Inoue, T. Kawakami, A. Nishikawa. National Institute of Health Sciences, Tokyo, Japan

P303-013BIOKINETICS OF GOLD NANOPARTICLES IN THE RAT. T. Morais (1), M. Elisa Soares (1), S. Fraga (1), H. Carmo (1), J. Alberto Duarte (2), M. Lourdes Bastos (1). (1) REQUIMTE, Porto, Portugal; (2) CIAFEL, Portugal

P303-014INABILITY TO USE STANDARD ALGAE TEST ( ISO 14442) TO EVALUATE EFFECTS OF BARE AND COATED GOLD NANOPARTICLES AND BARE AND COATED COBALT FERRITE NANOPARTICLES COFE2O4 ON THE ALGAE SCENEDESMUS SUBSPICATUS. M. Núñez García (1), A. López Herranz (1), E. Perez Pastrana (2), L. Cuevas

(2), A. Cañas (1), J. A. Jimenez (1), G. Diaz López (1), J. P. García Camblero (1), A. Castaño Calvo (1). (1) Instituto de Salud Carlos III. Centro Nacional de Sanidad Ambiental, Majadahonda, Spain; (2) Instituto de Salud Carlos III,

P303-015ANATASE TITANIUM DIOXIDE NANOPARTICLES INDUCE THE SECRETION OF THE CYTOKINE IL6 BY PRE-OSTEOBLAST CELLS. M. C. Bernier, K. El-Kirat, M. Vayssade. Université de Technologie de Compiègne, COMPIEGNE, France

P303-016COMPARATIVE PULMONARY TOXICITY ASSESSMENT OF PRISTINE AND FUNCTIONALIZED MULTI-WALLED CARBON NANOTUBES INTRATRACHEALLY INSTILLED IN RATS. E. Roda (1), T. Coccini (2), S. Barni (3), L. Manzo (4). (1) Toxicology Division and European Centre for Nanomedicine, University of Pavia, Italy, Pavia, Italy; (2) Toxicology Division, IRCCS Maugeri Foundation, Institute of Pavia, Italy, Pavia, Italy; (3) Dept. Animal Biology, University of Pavia, Italy, Pavia, Italy; (4) Toxicology Division and European Centre for Nanomedicine, University of Pavia, and IRCCS Maugeri Foundation, Pavia, Italy, Pavia, Italy

P303-017INFLUENCE OF SURFACE COATING ON THE TOXICITY OF GOLD NANOPARTICLES IN CACO-2 CELLS. D. Fernandes, H. Carmo, M. L. Bastos, S. Fraga. REQUIMTE/Faculty of Pharmacy/University of Porto, Porto, Portugal

P303-018KINETICS AND OXIDATIVE STRESS EVALUATION OF SILICA NANOPARTICLES DOPED WITH CADMIUM AFTER INTRATRACHEAL INSTILLIATION IN RAT. T. Coccini (1), E. Roda (2), C. Signorini (3), M. Goldoni (4), A. Giardini (3), A. Mutti (5), L. Manzo (6). (1) Toxicology Division, IRCCS Maugeri Foundation, Institute of Pavia, Italy, Pavia, Italy; (2) Toxicology Division and European Centre for Nanomedicine, University of Pavia, Italy, Pavia, Italy; (3) Dept. Pathophysiology, Experimental Medicine, and Public Health, University of Siena, Italy, ; (4) Laboratory of Industrial Toxicology, Dept. Clinical Medicine, Nephrology and Health Sciences, and ISPESL Research Centre, University of Parma, Italy ; (5) Laboratory of Industrial Toxicology, Dept. Clinical Medicine, Nephrology and Health Sciences, University of Parma, Italy; (6) Toxicology Division and European Centre for Nanomedicine, University of Pavia, and IRCCS Maugeri Foundation, Pavia, Italy

P303-019TISSUE DISTRIBUTION AND TOXICITY OF TITANIUM DIOXIDE NANOPARTICLES IN RATS AFTER REPEATED DERMAL EXPOSURE. Y. Ikarashi, Y. Aiba, Y. Takita, T. Uchino, T. Nishimura. National Institute of Health Sciences, Tokyo, Japan

BARCELONAIUTOX 2010


81

P303-020A SIZE DEPENDENT TOXICITY STUDY OF A NANOEMULSION CONTAINING DEAD SEA MINERALS AS THE ACTIVE AGENT AND DESIGNED TO TREAT SKIN CONDITIONS. B. Suarez-Merino (1), C. Aristimuño (1), A. Aspiazu (1), L. Larush (2), F. Goñi De Cerio (1). (1) Gaiker Technological Centre, Zamudio, Spain (2) The Center of Nanoscience and Nanotechnology, Jerusalem, Israel

P303-021POSSIBLE ROLE OF PAPR-1 IN PROTECTING HUMAN HACAT AGAINST CYTOTOXICITY OF SIO2 NANOPARTICLES. C. M. Gong, Z. Zhuang. Shenzhen Center for Disease Control and Prevention; School of Public Health, Sun Yat-sen University, Shenzhen, China

P303-022TISSUE DISTRIBUTION OF FULLERENE AFTER INJECTION INTO RAT TAIL VEIN TO MIMIC THE ABSORPTION FROM THE DIGESTIVE TRACT. T. Nishimura, R. Kubota, K. Shimizu, M. Tahara, T. Obama, N. Sugimoto, J. Kanno, A. Hirose. National Institute of Health Sciences, Tokyo, Japan

P303-023SILVER NANOPARTICLES INDUCED OXIDATIVE STRESS AND APOPTOSIS BY A MECHANISM INVOLVING PKCÆ DOWN-REGULATION IN HUMAN LUNG CARCINOMA CELLS.. C. W. Song, Y. S. Lee, M. S. Choi, K. Lee, S. Yoon. Korea Institute of Toxicology / Inhalation Toxicology Center, Jeongeup, Korea, Republic of

P303-024TISSUE DISTRIBUTION OF FULLERENE AFTER INJECTION INTO RAT TAIL VEIN TO MIMIC THE ABSORPTION FROM THE DIGESTIVE TRACT. T. Nishimura, R. Kubota, K. Shimizu, M. Tahara, T. Obama, N. Sugimoto, J. Kanno, A. Hirose. National Institute of Health Sciences, Tokyo, Japan

P303-025NANOMATERIAL TOXICOLOGY - IMPORTANCE OF CHRONIC TOXICITY ASSESSMENT. J. Kanno, A. Takagi, T. Nishimura, A. Hirose. National Institute of Health Sciences, Tokyo, Japan

P303-026THE ANTIOXIDATIVE RESPONSE OF MRC-5 CELL LINE TO FE2O3 NANOPARTICLES EXPOSURE IS NOT EFFICIENT. M. Radu (1), M. C. Munteanu (1), C. Sima (2), A. I. Serban (3), C. Grigoriu (2), M. Costache (1), A. Dinischiotu (1). (1) University of Bucharest, Bucharest, Romania; (2) National Institute of Laser, Plasma and Radiation Physics, Romania; (3)

University of Agricultural Studies and Veterinary Medicine, Romania

P303-027ABSORPTION, BIODISTRIBUTION AND ACUTE TOXICITY OF COBALT FERRITE NP, GOLD NP HYALUROIC ACID -COATED GOLD NANOPARTICLES IN RATS. C. Porredon, D. Ramos, J. De Lapuente, L. Camps, M. Borràs. Parc Científic de Barcelona, Barcelona, Spain

P303-028INHALATION TOXICITY STUDIES WITH 12 NANOMATERIALS - COMPARING EFFECTS AND DISTRIBUTIONIN THE LUNG. R. Landsiedel, L. Ma-Hock, S. Treumann, V. Strauss, W. Wohlleben, K. Wiench, B. V. Ravenzwaay. BASF SE, Ludwigshafen, Germany

P303-029METALLIC NANOPARTICLES AND IN VITRO CYTOTOXICITY ASSESSMENT. H. Parkkola, L. Vivero, M. Vega, M. Ramis, J. Querol, J. Sendra. Endor Nanotechnologies, Barcelona, Spain

P303-030TOXICITY STUDIES OF POLY(ANHYDRIDE) NANOPARTICLES. P. Ojer (1), A. Lopez De Cerain (1), P. Areses (2), I. Peñuelas (2), J. M. Irache (1). (1) University of Navarra, PAMPLONA, Spain; (2) Clínica Universidad de Navarra, PAMPLONA, Spain

P303-031DIFFICULTIES ENCOUNTERED IN THE EVALUATION OF THE CYTOTOXICITY OF BARE AND COATED GOLD NANOPARTICLES BY WST-1 AND LDH. A. Egizabal (1), L. Goikoetxea (1), N. Briz (1), N. Alvarez (1), L. Ballester (1), J. Lorenzo (1), J. Sendra (2). (1) Inasmet Tecnalia,Spain (2) Endor Nanotechnologies, Spain

P303-032CELLULAR TOXICITY AND HAEMOLYTIC POTENTIAL OF FUNCTIONALIZED FULLERENE AND MULTI WALLED CARBON NANOTUBES. R. Bonafè, S. Bussi, A. Maiocchi. Bracco Imaging Spa, Italy

P303-033COMPARATIVE TOXICITY OF COPPER AND TITANIUM OXIDE NANOPARTICLES ON HUMAN ALVEOLAR EPITHELIAL CELLS. P. Mantecca (1), E. Moschini (1), M. Gualtieri (1), E. Longhin (1), U. Fascio (2), M. Camatini (1). (1) Università Milano Bicocca, Milan, Italy; (2) Università Milano, Italy

P303-034BEHAVIOR OF GOLD NANOPARTICLES COATED WITH HYALURONAN: CITOTOXICITY, CELL INTERNALIZATION AND RAT BIODISTRIBUTION. M. Borras (1), J. Sendra

(2), C. Di Guglielmo (1), H. Parkkola (2), M. Ramis (2), J. De Lapuente (1), C. Porredon (1). (1) UTOX, Barcelona, Spain (2) Endornanotechnologies, Spain

P303-035EFFECT OF MAGHEMITE NANOPARTICLES SIZE ON CYTOTOXICITY AND BIOKINETICS IN VITRO. F. Palacio (1), L. Mohamed Ali (1), A. Millan (1), L. Gabilongo (1), R. Piñol (1), V. Sorribas (2). (1) University of Zaragoza - CSIC, Zaragoza, Spain; (2) University of Zaragoza - Toxicology,

P303-036NANOSCALE METHODS FOR NANOTOXICOLOGY. E. Silbergeld (1), K. Clark (1), J. Nyland (2), H. Katz (3). (1) Johns Hopkins School of Public Health, Baltimore, United States; (2)

University of South Carolina, Columbia, United States; (3) Johns Hopkins University, Baltimore, United States

P303-037DNA DAMAGE AND CYTOTOXICITY IN HUMAN BRONCHIAL NORMAL CELLS (BEAS-2B) EXPOSED TO MULTI-WALLED CARBON NANOTUBES (MWCNTS). D. Cavallo, C. L. Ursini, A. Ciervo, A. M. Fresegna, R. Maiello, S. Iavicoli. ISPESL, National Institute of Occupational Safety and Prevention, Monteporzio Catone, Italy

P303-038IN VITRO TOXICITY ASSESSMENT OF SILVER NANOPARTICLES IN CHANG LIVER CELLS AND J-774 MACROPHAGES. L. Garza-Ocañas (1), M. Ramirez-Cabrera (1), M. T. Zanatta-Calderon (1), R. Lujan-Rangel (1), D. A. Ferrer (2), M. J. Yacaman (3). (1) Fac De Medicina Universidad Autonoma De Nuevo Leon, (2) The University Of Texas At Austin Usa, (3) The University Of Texas At San Antonio Usa.

P303-039IN VITRO CYTOTOXICITY AND CELLULAR UPTAKE OF GOLD NANOPARTICLES. J. De Lapuente, D. Ramos, C. Porredon, C. Di Guglielmo, M. Borràs. Parc Cientific, Barcelona, Barcelona, Spain


82

P303-041SAFETY ASSESSMENT OF NANOMEDICINES. J. A. Vericat. Noscira & European Technology Platform on Nanomedicines, Tres Cantos, Spain

P303-042COMPARISON BETWEEN TWO DIFFERENT EXPOSURE METHODS, VIA CULTURE MEDIUM AND EXPOSURE AT THE AIR LIQUID INTERFACE, OF ZNO-NANOPARTICLES TO A-549-CELLS. S. Wagner (1), N. Möhle (2), O. Krischenowski (2), S. Röker (2), D. Bahnemann (1), T. Scheper (1), M. Aufderheide (2), K. Cornelia (1). (1) Institut für Technische Chemie, Leibniz Universität Hannover, Hannover, Germany; (2) Cultex Laboratories GmbH,, Hannover, Germany

P303-043THE EFFECTS OF SILVER NANOPARTICLES ON MALE RATS SPERM QUANTITY AND QUALITY. M. Dobrzyńska (1), A. Gajowik (1), J. Radzikowska (1), J. Gromadzka-Ostrowska (2), M. Oczkowski (2), A. Krawczyńska (2), G. Brunborg (3), M. Dusinska (4), A. Lankoff (5), M. Kruszewski (5). (1) National Institute of Public Health- National Institute of Hygiene, Warsaw, Poland; (2) Warsaw University of Life Sciences, ; (3) Norwegian Institute of Public Health, (4) Norwegian Institute of Air Research, Norway; (5) Institute of Nuclear Chemistry and Technology, Poland

P303-044ELECTRON MICROSCOPY OF DAPHNIA MAGNA MIDGUT EPITHELIUM UPON ACUTE EXPOSURE TO CUO NANOPARTICLES: TOXIC EFFECT OF CU-IONS CONFIRMED?. M. Heinlaan (1), H. C. Dubourguier (1), B. Arbeille (2), G. Prensier (2), A. Kahru (1). (1) National Institute of Chemical Physics and Biophysics, Tallinn, Estonia; (2) University of François Rabelais, Tours Cedex, France

P303-050INTRACELLUAR REACTIVE OXYGEN SPECIES ARE ASSOCIATED WITH SIO2 NANOPARTICLE-INDUCED CYTOTOXICITY AND DNA DAMAGE IN HACAT CEL. Z. X. Zhuang, C. M. Gong, L. Q. Yang, J. J. Liu. Shenzhen Center for Disease Control and Prevention; School of Public Health, Sun Yat-sen University, Shenzhen, China

P303-051CYTOTOXICITY OF GOLD NANOPARTICLES FUNCIONALIZED WITH CITRATE AND PENTAPEPTIDES GROUPS ON HEP G2 CELLS. H. Faria. Faculty of Pharmacy, University of Porto, Porto, Portugal

P304: INDUSTRIAL CONTAMINANTS

P304-0011-HYDROXYPYRENE AS A BIOCHEMICAL MARKER FOR ASSESSMENT OF PAH CONTAMINATION IN THE CZECH RIVERS. Z. Svobodova (1), J. Blahova (1), K. Kruzikova

(1), D. Leontovycova (2), V. Kodes (2), T. Randak (3). (1) University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic; (2) Czech Hydrometeorological Institute Praha, Praha, Czech Republic; (3) University of South Bohemia in Ceské Budejovice, Research Institute of Fish Culture and Hydrobiology, Czech Republic

P304-002BROMINATED FLAME RETARDANTS POTENTIAL CONTAMINATION FROM END OF LIFE PRODUCTS IN MEXICO. I. Gavilán-García (1), E. Santos-Santos (1), A. Gavilán-García (2). (1) Facultad de Química, UNAM, México D.F., Mexico; (2) Instituto Nacional de Ecología, México D.F., Mexico

P304-003ELECTRONIC WASTES DIAGNOSIS AND MASS FLOW ANALYSIS IN MEXICO. A. Gavilán-García (1), L. Cedillo-Becerril (1), G. Román-Moguel (2), E. Santos-Santos (3). (1) Instituto Nacional de Ecología, México D.F., Mexico; (2) Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y Desarrollo, Instituto Politécnico Nacional, México, D.F., Mexico; (3) Facultad de Química, UNAM, México D.F., Mexico

P304-004TOXICOLOGICAL PROFILE BY JATROPHA CURCAS L.. E. Barahona, P. Díaz, V. Castellano, A. Anadón. Universidad Complutense de Madrid, Madrid, Spain

P304-005PM2.5-BOUNDED PAHS FROM TWO ZONES OF THE METROPOLITAN AREA OF MONTERREY, NUEVO LEON, MEXICO. L. Garza-Ocañas, H. Garza-Ulloa, O. Gonzalez-Santiago, R. Lujan-Rangel, C. T. Badillo-Castañeda. Fac de Medicina, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico

P304-006OCCURRENCE OF PERFLUOROALKYL SUBSTANCES IN SVITAVA AND SVRATKA RIVERS, CZECH REPUBLIC J. Kovarova (1), P. Marsalek (1), J. Jurcikova (2), Z. Svobodova (1). (1) University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic; (2) Institute of Public Health Ostrava, Czech Republic,

P304-007MERCURY TOXICOKINETICS DURING LARVAL AND JUVENILE STAGES IN RAINBOW TROUT. K. Kruzikova, R. Kensova, J. Havranek, Z. Svobodova. University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic, Brno, Czech Republic

P304-008ALUMINUM ANALYSES IN MONTRICHARDIA LINIFERA (ANINGA), A WIDE RANGE DISTRIBUTED AMAZON MACROPHYTE. N. Santos Serrão De Castro (1), A. L. Ferreira De Almeida Lins (2), E. Conceição De Oliveira Santos (1), I. Maura De Jesus (1), C. Nahum Alves (3), M. De Oliveira Lima (1). (1) Evandro Chagas Institute, Lisboa, Portugal: (2) Museu Paraense Emilio Goeldi, Portugal; (3) Federal University of Pará, Portugal

P304-009PHYSIOCHEMICAL CARACTERIZATION OF ENVIRONMENTAL IMPACT IN TWO AMAZON RIVERS FROM THE RELEASE OF KAOLIN INDUSTRIAL WASTE. M. De Oliveira Lima (1), E. Conceição De Oliveira Santos (1), B. Santana Carneiro (1), K. Raimundo Freitas Faial (1), I. Maura De Jesus (1), R. De Alcântara Mendes (1), C. Nahum Alves (2). (1) Evandro Chagas Institute - Brazil, Belém, Brazil; (2) Federal University of Pará - Brazil,

P304-010ASSESSMENT OF PERFLUOROALKYL SUBSTANCES CONTAMINATION IN THE SVITAVA AND SVRATKA RIVERS, CZECH REPUBLIC. J. Blahova (1), J. Kovarova (1), P. Marsalek (1), J. Jurcikova (2), Z. Svobodova (1). (1) University of Veterinary and Pharmaceutical Sciences Brno, Department of Veterinary Public Health and Toxicology, Czech Republic, Brno, Czech Republic; (2) Institute of Public Health Ostrava, Czech Republic,

P305: FORENSIC TOXICOLOGY

P305-001EXTRACTION AND IDENTIFICATION TECHNIQUES TO DETECT TOXICOLOGY OF NEW THIOPHENE DERIVATIVES. M. Kreet. Ministry Of Justice, Egypt

P305-002EFFECT OF ALDICARB INSECTICIDE FORMULATION ON ITS DETECTION IN POSTMORTEM HUMAN SPECIMEN. F. Elwan. Medico- legal Administration, Cairo, Egypt

BARCELONAIUTOX 2010


83

P305-003EVALUATING HABITS OF ABUSE OF ILLICIT DRUGS IN A TOURIST REGION (THE CANARY ISLANDS, SPAIN) THROUGH THE DETERMINATION OF DRUG RESIDUES IN EURO BANKNOTES. O. P. Luzardo, M. Zumbado, M. Almeida-González, L. D. Boada. University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain

P305-004POLYDRUG CONSUMPTION IN METHADONE-RELATED DEATHS IN SOUTHERN SPAIN FORM 2006-2007. M. L. Soria Sanchez, R. Garcia Repetto. National Institute of Toxicology, Seville, Spain

P305-005A COCAINE BODY PACKER CASE REPORT: CLINICAL AND FORENSIC ASPECTS. R. J. Dinis-Oliveira (1), F. Carvalho (2), T. Magalhães (3), A. Santos (4). (1) Department of Clinical Analysis and Public Health, Center of Research in Health Technologies (CITS)-IPSN-CESPU, CRL. Faculty of Medicine, University of Porto. REQUIMTE, Department of Toxicology, Faculty of Pharmacy, University of Porto., Vila Nova de Famalicão, Portugal; (2) REQUIMTE, Department of Toxicology, Faculty of Pharmacy, University of Porto., (3) Faculty of Medicine, University of Porto. Biomedical Sciences Institute Abel Salazar, University of Porto. National Institute of Legal Medicine I.P., Faculty of Medicine, University of Porto.; (4) Faculty of Medicine, University of Porto. National Institute of Legal Medicine I.P., Faculty of Medicine, University of Porto., Portugal

P305-006CHEMICO-TOXICOLOGICAL STUDY CONCERNING A FATAL CASE OF METALLIC MERCURY INJECTION. J. K. Sadlik. Institute of Forensic Research, Krakow, Poland, Krakow, Poland

P305-007APPLICATION OF ICP-OES AND CV-AAS TO DETERMINATION OF MERCURY IN AN UNUSUAL FATAL CASE OF LONG-TERM EXPOSURE TO ELEMENTAL MERCURY IN A CHILD. T. Lech. 1). Jagiellonian University, 2). Institute Of Forensic Research, Poland

P305-008GENERAL UNKNOWN SCREENING OF ILLICIT DRUGS: A NOVEL APPROACH USING HIGH RESOLUTION AND ACCURATE MASS. B. Duretz (1), S. Robinson (1), S. Scurati (1), E. Genin (1), D. Lamiable (2). (1) ThermoFisher, Courtaboeuf Cedex, France, Metropolitan; (2) Reims Hospital,

P305-009CASE REPORT: AN UNUSUAL SUICIDE POISONING WITH BUTANE GAS. M. J. De Luis Y García, V. Uroz, O. Fernández, J. A. Sánchez. Escuela De Medicina Legal Y Forense. Madrid, Spain

P305-012CORRECTION OF COCAINE VALUES BY CREATININE IN ADDICTS FOR ESTABLISHING THE DILUTION FACTOR AND RETAILS. L. Börgel, C. Criollo, A. Carreño. SERVITOX/Legal Medicine Department, Universidad de Chile, Santiago, Chile

P306: ANALYTICAL TOXICOLOGY

P306-001DETERMINATION OF NITRATE AND NITRITE IN MILK PRODUCTS COMMERCIALIZED IN THE SOUTHERN REGION OF MINAS GERAIS STATE, BRAZIL: COMPARISON BETWEEN THE FLOW INJECTION ANALYSIS AND THE SPECTROPHOTOMETRIC CONVENTIONAL METHOD. I. Martins, T. Silva, P. Lima, E. Figueiredo, P. Maia. Laboratory Of Toxicological Analysis, Federal University Of Alfenas, Brazil P306-002HIGHTHROUGHPUT METHOD FOR THE DETERMINATION OF CLOZAPINE AND NORCLOZAPINE WITH FIA TANDEM MASS SPECTROMETRY. A. C. Lua (1), I. A. Lua

(1), H. C. Huang (2). (1) Tzu Chi University, Hualien, Taiwan; (2) Yuli Hospital, Yu-Li, Hualien, Taiwan

P306-003PREDICTION OF DRUG TOXICITY IN HEPG2 CELLS USING LASER SCANNING CYTOMETRY. A. Juan-Garcia (1), J. P. Robinson (2), V. J. Davisson (3), C. Juan (4), N. Li (5), P. Narayanan (5), M. Ruiz (4), G. Font (4). (1) Purdue University Cytometry Laboratories (Pucl) - Bindley Bioscience Center - Discovery Park - In, Usa, (2) Purdue University Cytometry Laboratories (Pucl) - Dpt. Of Basic Medical Science And Dpt. Of Biomedical Engineering - Purdue University - In, Usa, (3) Dpt. Of Medicinal Chemistry And Molecular Pharmacology - Purdue University - In, Usa, (4) Dept. De Medicina Preventiva I Salut Publica, Ciencies De L’ Alimentació, Toxicologia I Medicina Legal, Lab. De Toxicologia - Universitat De Valencia - Spain, (5) Investigative Toxicology - Amgen Inc. - Seatle, Wa, Usa.

P306-004DEVELOPMENT OF A GC/IP-MS METHOD FOR SIMULTANEOUS QUANTIFICATION OF PARA AND META-SYNEPHRINE IN CACO-2 CELLS. L. Grazziotin Rossato, V. Marisa Costa, P. Guedes De Pinho, R. Silva, F. Carvalho, H. Carmo, M. D. L. Bastos, F. Remião. REQUIMTE (Rede de Química e Tecnologia), Porto, Portugal

P306-005POSSIBILITIES OF MICROSCOPIC DETECTION OF HEAVY METALS IONS IN PLANT TISSUES. R. Kizek (1), O. Krystofova (1), P. Babula (2), M. Beklova (2), L. Havel (1), J. Zehnalek (1). (1) Mendel University, Brno, Czech Republic (2) University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic

P306-006VALIDATION OF GC HEAD SPACE METHOD FOR DETERMINATION OF TOLUENE: APPLICATION TO EXPOSED SPRAY PAINT WORKERS. G. Mergen, E. Dural, T. Soylemezoglu. Ankara University Institute of Forensic Medicine, Ankara, Turkey

P306-008COMPARISON AND VALIDATION OF DRIED BLOOD SPOT (DBS) AND SOLID PHASE EXTRACTION (SPE) TECHNIQUES. F. Pastori, D. Salerno, G. Oberto, S. Villa, R. Ricci, F. R. Calfapietra. RTC – Research Toxicology Centre., Pomezia, Italy

P306-009DEVELOPMENT OF A METHOD OF DOSAGE OF CLOZAPINE BY SELECTIVE ELECTRODE TO THE IODIDES. T. Hassen, H. Kilani, D. Wahiba, N. Mohamed Fadhel. University Hospital of Monastir, Monastir, Tunisia

P306-010ACCUMULATION OF CLENBUTEROL RESIDUES IN DIFFERENT PIGMENTED MOUSE HAIR. J. Pleadin (1), A. Vulić (1), R. Stojković (2), N. Perši (1). (1) Croatian Veterinary Institute, Zagreb, Croatia (Hrvatska); (2) Institute Ruđer Bošković,

P306-011DETERMINING THE BIOMARKER CYANIDE METABOLITE 2-AMINOTHIAZOLINE-4-CARBOXYLIC ACID IN MICE LIVER AFTER CYANIDE EXPOSURE. I. Petrikovics, K. Stafford, D. Thompson, P. Jayanna, J. Yu. Sam Houston State University, Huntsville, United States


84

P306-012ANALYTICAL FINDINGS OF SYSTEMATICALLY PURCHASED ‘LEGAL HIGHS’ FROM THE INTERNET. D. M. Wood (1), S. Davies (2), G. Smith (2), J. Button (2), J. Ramsey (3), D. W. Holt (2), P. I. Dargan (1). (1) Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom; (2) St George’s, University of London, UK; (3) TICTAC Communications Ltd, United Kingdom

P306-013LEAD CONTENT OF MEXICAN CANDY “MIGUELITO”. L. Saldívar, N. Munguía, I. Ramos. UNAM, Ciudad Universitaria, Mexico

P306-014QUANTIFICATION OF TRACE METALS IN SWEETENERS AVAILABLE IN PORTUGUESE MARKET. M. L. Mateus, M. Henriques, E. Mendes. Institute for Medicines and Pharmaceutical Sciences (i-Med), Lisbon, Portugal

P306-015DETERMINATION OF MYCOTOXINS IN MULTICEREAL FLOUR BY MATRIX SOLID PHASE DISPERSION AND LC-MS/MS. J. Manes, J. Rubert, C. Soler, G. Font.University of Valencia, Burjassot, Spain

P307: METALS

P307-001TOXICOLOGICAL AND PATHOLOGICAL STUDY OF THE TOXIC EFFECT OF CHROMIUM AND LEAD ON THE OREOCHROMIS NILOTICUS. I. Shaheed. Faculty of Veterinary Medicine, Cairo University, Giza, Egypt

P307-002RESEARCH ON THE CELL AND MOLECULE MECHANISM OF ACUTE TOXICITY OF NICKEL CARBONYL IN RATS. N. Cheng. Basic Medical School of Lanzhou University; Key Laboratory of Preclinical Study for New Medicine of Gansu Province,Lanzhou University, Lanzhou, China

P307-003DIETARY EXPOSURE TO POTENTIALLY TOXIC TRACE ELEMENTS IN NIGERIA: AN OVERVIEW. O. E. Orisakwe. Nnamdi Azikiwe University, Nigeria

P307-004LEVELS OF LITHIUM IN THE SIX MOST TAKEN GROUPS OF FOOD AMONG THE CANARIAN POPULATION. C. Rubio Armendáriz, D. Gonzalez-Weller, A. J. Gutierrez Fernandez, A. Hardisson De La Torre. Universidad de La Laguna, La Laguna, Spain

P307-005IN VITRO TOXIC EFFECT OF LEAD ON HUMAN SPERM CREATINE KINASE ACTIVITY. M. A. Ghaffari, B. Motlagh. Jundishapour University of Medical Sciences, Ahwaz, Iran (Islamic Republic of)

P307-006THE TOXIC EFFECT OF COPPER ON HUMAN LOW DENSITY LIPOPROTEIN OXIDATION. M. Hashemi-Manesh. Hygiene Teacher, Salehin Primary School, Ahwaz, Iran

P307-007INFLUENCE OF VITAMIN C SUPPLEMENTATION ON LEAD-INDUCED HISTOPATHOLOGICAL ALTERATIONS IN MALE RATS. Y. El-Sayed (1), M. El-Neweshy (2). (1)

Department Of Veterinary Forensic Medicine And Toxicology, Faculty Of Veterinary Medicine, Alexandria University (Damanhur Branch), Egypt (2) Department Of Veterinary Pathology And Parasitology, Faculty Of Veterinary Medicine, Alexandria University. Egypt

P307-008OVEREXPRESSION OF RAD23 CONFERS RESISTANCE TO METHYLMERCURY IN YEAST CELLS VIA INHIBITION OF DEGRADATION OF PNG1. G. W. Hwang, A. Naganuma. Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

P307-009MERCURY SPECIATION IN CONTAMINATED SOILS FROM SPANISH-COLONY MINING ACTIVITIES IN THE MEXICAN STATES OF GUANAJUATO, HIDALGO AND ZACATECAS. E. Santos-Santos (1), I. Gavilán-García (1), A. Gavilán-García (2), S. Suárez (1). (1) Facultad de Química, UNAM, México D.F., Mexico; (2) Instituto Nacional de Ecología, México D.F., Mexico

P307-010HEAVY METALS IN SANTA CRUZ DE TENERIFE HARBOUR FLOOR. C. Hernández Sánchez, C. Rubio Armendáriz, A. J. Gutiérrez Fernánez, A. Hardisson De La Torre. Área de Toxicología de la Universidad de La Laguna, Santa Cruz de Tenerife, Spain

P307-011NRF2-DEPENDENT PROTECTION AGAINST METHYLMERCURY TOXICITY IN VITRO AND IN VIVO. Y. Kumagai. Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

P307-012INTERACTION OF CAPTOPRIL WITH IRON(III) - EFFECT ON OXIDATIVE STRESS AND MINERAL STATUS IN RATS. V. Eybl, D. Kotyzová, A. Hodková. Charles University in Prague, Faculty of Medicine in Pilsen, Pilsen, Czech Republic

P307-013PROTEOMIC APPROACH TO EMBRYOTOXIC MECHANISMS OF INDIUM IN CULTURED RAT EMBRYOS. A. Miyajima-Tabata (1), M. Nakajima (2), K. Mitsunaga (3), M. Sunouchi (1), O. Doi (4), Y. Sekino (1), M. Usami (1). (1) National Institute of Health Sciences, Tokyo, Japan; (2) Asahi Kasei Pharma Corporation, Japan; (3) Toho University, Japan; (4) Gifu University, Japan

P307-014CHROMIUM(VI) INHIBITS MOUSE METALLOTHIONEIN-I GENE TRANSCRIPTION BY MODIFYING TRANSACTIVATION POTENTIAL OF THE CO-ACTIVATOR P300. T. Kimura (1), F. Okumura (1), A. Onodera (2), T. Nakanishi (3), N. Itoh (2), M. Isobe (1). (1) Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Japan; (2) Graduate School of Pharmaceutical Sciences, Osaka University, Japan; (3) Gifu Pharmaceutical University, Japan

P307-015EVALUATION OF THE UPTAKE OF CADMIUM AND SILVER IN ZEBRAFISH EMBRYOS TOXICITY ASSAYS. M. Olasagasti, M. A. Garcia, S. Rainieri. AZTI-TECNALIA, DERIO, Spain

BARCELONAIUTOX 2010


85

P307-016ORAL CADMIUM EXPOSURE AND PLACENTAL STEROIDOGENESIS IN RATS. A. Mikolić, M. Piasek. Institute for Medical Research and Occupational Health, Zagreb, Croatia (Hrvatska)

P307-017AGE-RELATED RELATIONSHIP BETWEEN CADMIUM EXPOSURE AND ITS RENAL ADVERSE EFFECT OBSERVED IN FEMALE JAPANESE FARMERS EXPOSED TO CADMIUM THROUGH RICE CONSUMPTION. H. Horiguchi (1), E. Oguma (1), S. Sasaki (2), H. Okubo (2), K. Murakami (2), K. Miyamoto (1), Y. Hosoi (1), F. Kayama (1). (1) Jichi Medical University, Tochigi, Japan; (2) Tokyo University,

P307-018EFFECT OF LEAD LEVELS IN BREAST MILK ON THE ESTIMATED INFANT DAILY INTAKE OF LEAD. M. Paoliello (1), G. Koyashiki (1), E. De Capitani (2). (1) State University of Londrina, Londrina, Brazil; (2) State University of Campinas,

P307-019COULD SELENIUM AND OMEGA-3 MODIFY THE OXIDATIVE DAMAGE PROMOTED BY METHYLMERCURY AT LOW DOSES IN RATS? D. Grotto (1), J. M. Serpeloni (1), A. M. Moro (2), M. F. Charão (2), S. C. Garcia (2), F. Barbosa Junior (1). (1) Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil; (2)

Universidade Federal do Rio Grande do Sul,

P307-020ADDITIVE EFFECT OF DL-PENICILLAMINE PLUS PRUSSIAN BLUE FOR THE ANTIDOTAL TREATMENT OF THALLOTOXICOSIS IN RATS. A. Monroy (1), C. Ríos (2), S. Montes (2). (1) Universidad Autonoma del Estado de Morelos, Cuernavaca, Mexico; (2) Instituto Nacional de Neurología y Neurocirugía, Distrito federal, Mexico

P307-021ENDOGENOUS LEVELS OF TRIBUTYLTIN DECREASES GLUR2 EXPRESSION CAUSING HIGHER SUSCEPTIBILITY TO GLUTAMATE TOXICITY. Y. Kotake, Y. Nakatsu, T. Takishita, S. Ohta. Hiroshima University, Hiroshima, Japan

P307-022CORRELATION BETWEEN TRACE ELEMENTS IN BLOOD AND URINE AND HUMAN REPRODUCTIVE INDICATORS. F. Moreira (1), A. C. Mancebo (2), F. Baptista (1), R. Gomes (1), M. D. C. Souza (2). (1) Fundação Oswaldo Cruz, Niterói, Brazil; (2) Clinica G&O Barra, Rio de Janeiro, Brazil

P307-023IMPORTANT ROLE OF ANTIOXIDANT ENZYMES IN THE SACCHAROMYCES CEREVISIAE SURVIVAL TO THE TOXICITY OF VANADIUM PENTOXIDE. A. Conim (1), I. Alves-Pereira (2), R. Ferreira (2). (1) Dep de Química, Escola de Ciências e Tecnologia, Universidade de Évora, Portugal, Évora, Portugal; (2) Dep de Química, Escola de Ciências e Tecnologia, Universidade de Évora, Instituto de Ciências Agrárias e Ambientais, Centro de Tecnologia Animal (ICAAM-CTA), Universidade de Évora, Portugal, Évora, Portugal

P307-024ASCORBATE PREVENTS PRO-OXIDANT EFFECTS OF VANADIUM PENTOXIDE ON WILD-TYPE SACCHAROMYCES CEREVISIAE UE-ME3. S. Gonçalves (1), R. Ferreira

(2), I. Alves-Pereira (2). (1) Dep de Química, Escola de Ciências e Tecnologia, Universidade de Évora, Évora, Portugal; (2) Dep de Química, Escola de Ciências e Tecnologia, Universidade de Évora, Instituto de Ciências Agrárias e Ambientais, Centro de Tecnologia Animal (ICAAM-CTA), Universidade de Évora, Portugal, Évora, Portugal

P307-025COMPARISON OF SYNTHETIC CHELATES AND COMPOST AT ENHANCING PHYTOEXTRACTION OF CD, NI AND PB FROM CONTAMINATED SOIL UNDER CANOLA CULTIVATION. M. Hajishah (1), M. Choram (2), A. Alizadeh (2). (1) Sazabpardazan Con.Eng.Co., Iran (Islamic Republic of) (2) College Of Agriculture, Shahid Chamran University. Iran (Islamic Republic of)

P307-026PARTICULATE COBALT AND SOLUBLE COBALT: SAME METAL BUT DIFFERENT TOXICITIES AS ASSESSED BY CELLULAR BIOLOGY AND INNOVATIVE PROTEOMIC APPROACHES. V. Malard (1), N. Sage (1), P. Gueraud (1), W. Naudin (1), M. Floriani (2), J. Armengaud (1), E. Quemeneur (1). (1) CEA, DSV, IBEB, Service de Biochimie et Toxicologie Nucléaire, BAGNOLS SUR CEZE, France; (2) Laboratory of Radioecology and Ecotoxicology, IRSN/DEI/SECRE, St Paul lez Durance, France

P307-027INTERACTION OF CADMIUM AND MANGANESE IN CELLULAR UPTAKE AND TOXICITY. S. Himeno, M. Doi, H. Fujishiro. Tokushima Bunri University, Tokushima, Japan

P307-028STRUCTURE-DEPENDENT ACTIVATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA BY ORGANOTIN COMPOUNDS. Y. Hiromori (1), J. I. Nishikawa (2), H. Nagase (1), T. Nakanishi (1). (1) Gifu Pharmaceutical University, Gifu, Japan; (2) Mukogawa Women’s University,

P307-029INORGANIC ARSENIC AND ITS METABOLITES INDUCE NEURAL STEM CELL APOPTOSIS. SYNERGISM OF FLUORIDE COEXPOSURE. V. Devesa I Perez (1), D. Vélez

(1), R. Montoro (1), J. Gimeno (1), R. Rocha (1), R. Martin (2), J. Canals (2). (1) CSIC, Spain(2) Universidad De Barcelona, Spain

P307-030STUDY OF INTESTINAL TRANSPORT OF F USING CACO-2 CELL LINE. V. Devesa, R. Rocha, R. Montoro, D. Vélez. CSIC, Paterna, Spain

P307-031MANGANESE-INDUCED DEVELOPMENT NEUROTOXICITY IS MEDIATED BY CHEMICAL SPECIATION AND PROBABLY BY MITOCHONDRIAL IMPAIRMENT. R. Bonne Hernandez (1), M. Farina (2), C. Suñol (3), S. Scholz (4), N. C. Souza-Pinto (1), B. Pannia Espósito (1). (1) University of Sao Paulo, Sao Paulo, Brazil; (2) Federal Universty of Santa Catarina, Brazil; (3) Instituto de Investigaciones Biomédicas de Barcelona, Spain; (4) Helmholtz Centre for Environmental Research, Germany

P307-032CHARACTERIZATION OF INTESTINAL ABSORPTION OF AS(III) USING CACO-2 CELL LINE. M. Calatayud, R. Montoro, D. Vélez, V. Devesa. CISC, Paterna, Spain

P307-033MANGANESE (II) INDUCED OXIDATIVE STRESS IS COUNTERACTED BY HSP 27 AND HSP 70 IN HEP G-2 CELL LINE. A. O. Hermenean (1), C. Tudor (2), L. Postolache (2), M. C. Munteanu (2), A. I. Serban (2), M. Costache (2), A. Dinischiotu (2). (1) Vasile Goldis Western University of Arad, Arad, Romania; (2) University of Bucharest,

P307-034N-ACETYLCYSTEINE INHIBITS CADMIUM-INDUCED CYTOTOXICITY IN HUMAN BREAST CANCER CELL LINE (MDA-MB468) M. Panjehpour, S. H. Alaie. School of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan, Iran (Islamic Republic of)


86

P307-035ULTRASTRUCTURAL AND BIOCHEMICAL ALTERATIONS IN THE LIVER OF CARASSIUS AURATUS GIBELIO (OSTEICHTHYES: CYPRINIDAE) INDUCED BY ACUTE DOSES OF MN2+. A. Ardelean (1), A. C. Staicu (2), M. C. Munteanu (2), A. Hermenean (1), M. Costache (2), A. Dinischiotu (2). (1) Vasile Goldis Western University of Arad, Arad, Romania; (2) University of Bucharest, Bucharest, Romania P307-036L-ARGININE TREATMENT SHOWS THERAPEUTIC POTENTIAL ON THE ADVERSE CARDIOVASCULAR EFFECTS OF LEAD EXPOSURE. S. Cordellini, A. Fresneda Da Silva. Universidade Estadual Paulista, Botucatu, Brazil

P307-037TOXICITY OF INCREASED INTRACELLULAR ZINC IN COLON CANCER CELLS. E. Rudolf, S. John, T. Briatka, M. Červinka. Charles University Faculty of Medicine, Hradec Králové, Czech Republic

P307-038HISTATIN-5 A SALIVARY TARGET FOR ALLERGENIC NICKEL(II). E. Kurowska, A. Bonna, Ł. Jaremko, M. Jaremko, M. Nowakowski, A. Ejchart, W. Bal. Institute of Biochemistry and Biophysics PAS, Warsaw, Poland

P307-039SP-1 TRANSCRIPTION FACTOR AS A TARGET FOR NICKEL TOXICITY. W. Bal (1), E. Kurowska (2), A. Bonna (2), A. Staszewska (2). (1) Central Institute of Labour Protection – National Research Institute, Warsaw, Poland; (2) Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

P307-040ARSENATE TRANSPORT THROUGH PI TRANSPORTERS. V. Sorribas, R. Villa-Bellosta. University of Zaragoza, Vet Faculty, Zaragoza, Spain

P307-041P-AMINOSALICYLIC ACID (PAS) ATTENUATES MANGANESE NEUROTOXICITY IN THE RAT. A. P. Marreilha Dos Santos (1), R. Lucas (1), V. Andrade (1), M. L. Mateus (1), M. Aschner (2), M. C. Batoreu (1). (1) I-Med-Ul, Faculty Of Pharmacy, University Of Lisbon, Portugal (2) Vanderbilt University, Medical Center, Usa.

P307-042THE EFFECT OF COOKING ON MERCURY BIOACCESIBLE CONTENTS OF PREDATORY FISH. S. Torres-Escribano, M. Calatayud, A. Ruiz, M. T. De La Flor, V. Devesa, D. Vélez, R. Montoro. Instituto de Agroquímica y Tecnología de los Alimentos (IATA-CSIC), Paterna, Spain

P307-043DNA DAMAGE AND DECREASED DNA REPAIR IN INDIVIDUALS EXPOSED TO ARSENIC AND LEAD IN A MINING SITE. I. N. Pérez-Maldonado, Y. Jasso-Pineda, F. Díaz-Barriga. Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico

P307-044CD-INDUCED EGFR TRANS-ACTIVATION LEADS TO STAT3 ACTIVATION AND MT-II EXPRESSION BY A MECHANISM INVOLVING PKC, SRC AND NADPH OXIDASEK. Martínez-Flores, B. Uribe Marín, V. Souza-Arroyo, L. Bucio Ortiz, E. Hernandez Perez, L. E. Gomez-Quiroz, M. C. Gutierrez-Ruiz.Universidad Autonoma Metropolitana Iztapalapa, Mexico, Mexico

P307-045RARE METALS AFFECT THE EXPRESSION LEVELS OF CLOCK GENES. N. Miura. Japan National Institute of Occupational Safety and Health (JNIOSH), Kawasaki, Japan

P307-046ESTROGENIC ACTIVITY OF SESAMOL FROM SESAME SEED AND ITS INTERACTION WITH THE EFFECT OF METALLOESTROGEN CADMIUM ON T47D HUMAN BREAST CANCER CELLS. J. Satayavivad (1), A. Thiantanawat (1), P. Pianjing (2), D. Visitnonthachai (1), K. Chaiyot (1), P. Watcharasit (1). (1) Chulabhorn Research Institute, Bangkok, Thailand; (2) Center of Excellence on Environmental Health, Toxicology and Management of Chemicals (ETM), Faculty of Science, Mahidol University, Rama 6 Rd, Bangkok 10400, Thailand,

P307-049LEVELS OF CHROME, NICKEL, STRONTIUM AND ALUMINUM IN MEAT (COLD MEAT, RABBIT, VISCERA AND RED MEAT) AND FISH TAKEN BY THE CANARIAN POPULATION. C. Rubio Armendáriz (1), D. González-Weller (2), A. J. Gutiérrez Fernández (1), A. Hardisson De La Torre (1). (1) La Laguna University, La Laguna, Spain; (2) Laboratory and sanitary inspection service. Health department of Tenerife. Canarian health service,

P307-052THE ROLE OF MITOCHONDRIA MEDIATED APOPTOSIS PATHWAY IN SERTOLI-GERM CELL APOPTOSIS INDUCED BY MANGANESE IN COCKS. S. W. Xu, S. Li, M. Y. Bi. College of Veterinary Medicine, Northeast Agricultural University, Haerbin, China

P307-054MICE EXPOSED TO SODIUM ARSENITE SHOW INCREASED EXPRESION OF AQP9 IN LIVER CELLS. C. Valdovinos Flores(1), M. Torres-Avila(1), P. Leal-Galicia(1), L. C. Sánchez Peña(2), L. M. Del Razo(2), M. E. Gonsebatt(1). (1) Instituto De Investigaciones Biomédicas,Mexico (2) Universidad Nacional Autónoma De México, CINVESTAV

P308: PESTICIDES

P308-001CORRELATION OF THERAPEUTIC EFFECT OBIDOXIME AND DOSING TIME IN THE ACUTE EXPERIMENTAL INTOXICATION BY A CHLORFENVINPHOS. G. Raszewski. Institute of Agricultural Medicine, Lublin, Poland

P308-002SEMEN QUALITY AND SPERM CHROMATIN INTEGRITY OF A DDT EXPOSED SOUTH AFRICAN POPULATION LIVING IN A MALARIA AREA. C. De Jager (1), N. Aneck-Hahn

(1), M. Bornman (1), P. Farias (2), M. Spanò (3). (1) University of Pretoria, Pretoria, South Africa; (2) Instituto Nacional de Salud Publica, Mexico; (3) ENEA Casaccia Research Center, Italy

P308-003ANTAGONIS OF PHOSPHINE-INDUCED CYTOTOXICITY IN HEPG2 CELL CUTURES BY ATP SUPPLIERS. H. Niknahad, M. Rashedinia, A. Jamshidzadeh. Department of Pharmacology and Toxicology, Faculty of Pharmacy, and Pharmaceutical Research Center, Shiraz University of Medical Sciences, Shiraz, Iran (Islamic Republic of)

P308-004EFFECTS OF CHRONIC TERBUTRYN EXPOSURE ON COMMON CARP (CYPRINUS CARPIO L).. J. Velíšek, E. Sudová, J. Máchová, V. Žlábek, Z. Svobodová. University of South Bohemia Ceske Budejovice, Vodnany, Czech Republic

BARCELONAIUTOX 2010


87

P308-005THE EFFECT OF CHRONIC EXPOSURE TO BIFENTHRIN AND TRANSIENT BRAIN ISCHEMIA ON WEIGHT GAIN IN MICE. B. Nieradko-Iwanicka, A. Borzęcki. Chair and Department of Hygiene, Medical University of Lublin, Lublin, Poland

P308-006DETERMINATION OF DIAZINON RESIDUE IN MELON AND CUCUMBER BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY. M. Moallem (1), A. Moallem (2), M. Balali Mood (2), M. Piralihamedani (2), K. Abdi (2). (1) KHOUZESTAN FORENSICMEDICAL ORGANIZATION, BOLVAR ANGHALAB, KAMPOLO, AHVAZ, IRAN, AHVAZ, Iran (Islamic Republic of); (2) Iran (Islamic Republic of)

P308-007DDT-DERIVATIVES PESTICIDES COULD MODULATE GH-IGF AXIS IN YOUNGSTERS. M. Zumbado (1), E. E. Álvarez-León (2), P. Lara (1), M. Almeida-González (1), O. P. Luzardo

(1), G. Hernández-Rodríguez (1), L. D. Boada (1). (1) University of Las Palmas de Gran Canaria and Instituto Canario de Investigación del Cáncer, Las Palmas de Gran Canaria, Spain; (2)

Canary Health Service and Instituto Canario de Investigación del Cáncer, Las Palmas de Gran Canaria, Spain P308-008PROGRESS OF ACETYLCHOLINESTERASE REACTIVATORS AGAINST ORGANOPHOSPHORUS PESTICIDES – ALMOST 60 YEARS SINCE PRALIDOXIME. K. Musilek

(1), O. Holas (2), M. Pohanka (1), V. Opletalova (2), K. Kuca (1). (1) University of Defence / Faculty of Military Health Sciences, Hradec Kralove, Czech Republic; (2) Charles University / Faculty of Pharmacy, Hradec Kralove, Czech Republic

P308-009NEUROTOXIC EFFECTS OF ENDOSULFAN ADMINISTERED THROUGOUT PREGNANCY AND LACTATION ON STRIATAL AMINO ACID CONCENTRATION. A. Caride, T. Cabaleiro, G. Bernardez, A. Lafuente. University of Vigo, Orense, Spain

P308-010VARIATIONS ON STRIATAL BIOGENIC AMINE CONCENTRATION INDUCED BY ENDOSULFAN EXPOSURE IN MALE OFFSPRING RATS. A. Lafuente, T. Cabaleiro, A. Caride. University of Vigo, Orense, Spain

P308-011ASSESSMENT OF ACUTE TOXICITY OF 2.4-DICHLORPHENOXYACETIC ACID IN RATS DURING ISOLATED AND JOINT ACTION WITH SMALL DOSES OF IONIZING RADIATION. N. Kovalchuk, I. Pelo, O. Vavrinevich, V. Bardov, S. Omelchuk. Institute of Hygiene and Ecology of O.O.Bohomolets medical University, Kyiv, Ukraine

P308-012IN VIVO GENOTOXICITY TESTING OF FOUR SYNTHETIC PYRETHROIDS WITH COMBINATIONS PIPERONYL BUTOXIDE IN THE DROSOPHILA SMART ASSAY. B. Kaya (1), E. Demir (1), S. Kocaoğlu (1), H. Çetin (1), R. Marcos (2). (1) Akdeniz University, Antalya, Turkey; (2) Universitat Autònoma de Barcelona, Spain

P308-013EFFECT OF TERBUTHYLAZINE ON HUMAN CHROMATIN INTEGRITY EVALUATED BY CYTOME FISH ASSAY IN VITRO. M. Mladinic, D. Zeljezic. Institute for Medical Research and Occupational Health, Zagreb, Croatia (Hrvatska)

P308-014DETERMINATION OF METHYL PARATHION USING ZRO2-NANOPARTICLES MODIFIED CARBON PASTE ELECTRODE BY SQUARE WAVE VOLTAMMETRY. N. Rahbar

(1), H. Parham (2). 1) Ahvaz Jundishapur University of Medical Scieces, Ahvaz, Islamic Republic of Iran, Ahvaz, Iran (Islamic Republic of); (2) Department of Chemistry, College of Science, Shahid Chamran University, Ahvaz, Islamic Republic of Iran,

P308-015COMPARATIVE DETERMINATION OF THE EFFICACY OF BISPYRIDINIUM OXIMES IN PARAOXON POISONING. A. Lucic Vrdoljak (1), S. Berend (1), B. Radic (1), K. Kuca (2). (1) Institute for medical research and occupational health, Zagreb, Croatia (Hrvatska); (2) Faculty of Military Health Sciences, University of Defense,

P308-016OCCURRENCE OF PESTICIDE RESIDES IN WATER OF GORGAN ROUD. F. Hosseini Behbahani (1), Z. Nazari Khorasgani (2). (1) KKhouzestan Legal Medical Organization, Ahvaz, Islamic Republic of Iran, Ahvaz, Iran (Islamic Republic of); (2) Depr. of Toxicology & Pharmacology, Pharmacy School, Ahvaz Jondishapour University of Medical Science, Ahvaz, Islamic Republic of Iran,

P308-017ESTROGENIC EFFECTS OF THE ENDOCRINE DISRUPTORS DIELDRIN, ENDOSULFAN AND LINDANE IN NEURONAL CULTURES. V. Briz (1), J. M. Molina-Molina (2), B. Caballero (1), M. Fernández (2), N. Olea (2), E. Rodríguez-Farre (1), C. Suñol (1). (1) Institut d’Investigacions Biomediques de Barcelona, CSIC-IDIBAPS, CIBERESP, Barcelona, Spain; (2) Centro de Investigación Biomédica, Universidad de Granada, Spain,

P308-018THE RISK ASSESSMENT OF POLLUTION IN GROUNDWATER BY PESTICIDES AT THE LEVEL OF ORIENTAL MOROCCO: CASE OF THE PERIMETER IRRIGATED BY THE LOWER MOULOUYA. J. Benaboud, M. Elachouri. Mohammed Ier University, Faculty of Sciences, Oujda, Morocco

P308-019APPLICATION OF BIOMASS-DERIVED ACTIVATED CARBON FOR THE REMOVAL OF LINDANE FROM AQUEOUS SOLUTION. A. El-Kady (1), R. Carleer (2), J. Yperman (2), J. Y. Farah (1). (1) National Research Center, Dokki, Egypt; (2) Universiteit Hasselt, Diepenbeek, Belgium

P308-020WILDLIFE PESTICIDE POISONING IN PORTUGAL: RETROSPECTIVE ANALYTICAL RESULTS. A. Belas, B. Carrapiço, B. São Braz, A. Moreira. Faculty of Veterinary Medicine, UTL, Lisboa, Portugal

P308-021EFFECTS OF ENDOCRINE DISRUPTORS ON STEROIDOGENIC ENZYMES GENE EXPRESSION AND ON AROMATASE ACTIVITY IN TWO HUMAN CELL LINES. N. Quignot (1), S. Desmots (1), R. Barouki (2), E. Lemazurier (1). (1) INERIS, Verneuil-en-Halatte, France; (2) INSERM UMR-S 747, France

P308-022OPTIMIZATION, VALIDATION AND APPLICATION OF METHOD FOR ANALYSIS OF DIURON AND THEIR METABOLITES IN URINE OF RATS USING SPE AND HPLC-UV. S. Franco (1), M. R. R. Marchi (1), J. L. V. De Camargo (2). (1) Institute of Chemistry - UNESP, Araraquara, Brazil; (2) Faculty of Medicine - UNESP,

P308-023EFFECTS OF SUBCHRONIC EXPOSURE TO SPARTAKUS (PROCHLORAZ 450 G.L-1) ON HAEMATOLOGICAL, BIOCHEMICAL AND BIOMETRIC INDICES OF COMMON CARP CYPRINUS CARPIO. H. Modrá, I. Haluzová, J. Blahová, P. Maršálek, Z. Svobodová. University of Veterinary and Pharmaceutical Sciences Brno, Department of Veterinary Public Health and Toxicology, Faculty of Veterinary Hygiene and Ecology, Brno, Czech Republic


88

P308-024SUBACUTE ORAL TOXICITY OF COMBINATIONS OF SELECTED SYNTHETIC PYRETHROIDS, PIPERONYL BUTOXIDE AND TETRAMETHRIN IN RATS. O. Yavuz, A. Aksoy, Y. K. Das, M. Y. Gulbahar, D. Guvenc, E. Atmaca, F. G. Yarim, M. Cenesiz. Ondokuz Mayis University, Samsun, Turkey

P308-025EVALUATION OF LIQUID-LIQUID EXTRACTION AND DIFFERENT SOLID PHASE EXTRACTION CARTRIDGES FOR DETERMINATION OF SELECTED SYNTHETIC PYRETHROID INSECTICIDES IN WHOLE BLOOD. O. Yavuz, A. Aksoy, Y. K. Das, E. Atmaca. Ondokuz Mayis University, Samsun, Turkey

P308-026DUAL EFFECTS OF LINDANE (GAMMA-HEXACHLOROCYCLOHEXANE) ON CALCIUM HOMEOSTASIS AND EXOCYTOSIS IN RAT PC12 CELLS. H. J. Heusinkveld (1), G. O. Thomas (2), I. Lamot (1), M. Van Den Berg (1), A. B. Kroese (1), R. H. Westerink (1). (1) Institute for Risk Assessment Sciences, Neurotoxicology Research Group, Utrecht, Netherlands; (2)

Dept. of Environmental Sciences, Lancaster University, UK.,

P308-027INHIBITION AND SPONTANEOUS REACTIVATION OF ESTERASES BY ORGANOPHOSPHORUS COMPOUNDS IN PRESENCE OF THE SUBSTRATE: PARAOXON AS A MODEL. J. Estévez, I. Mangas, E. Vilanova. UNIVERSIDAD MIGUEL HERNÁNDEZ, Elche, Spain

P308-030DETERMINATION OF TISSUE BLOOD PARTITION COEFFICIENTS FOR NON-VOLATILE HERBICIDES AND FUNGICIDES USING NEGLIGIBLE DEPLETION SOLID PHASE MICROEXTRACTION (ND-SPME). R. Tremblay (1), D. Kim (2), J. Fisher (1). (1) Environmental Health Science Department, University of Georgia, Athens, GA, USA, Athens, United States; (2) Syngenta Crop Protection Inc, Greensboro, NC, USA, P308-031ASSESSMENT OF MULTI-RESIDUE ANALYSIS FOR TARGETED PESTICIDES ON SELECTED FRUITS OF KATHMANDU VALLEY. D. Dhakal. Department of Chemistry, Patan Multiple Campus, Tribhuvan University, Lalitpur, Nepal., Kathmandu, Nepal

P308-032THE SAGIR NETWORK IN FRANCE: A 40-YEAR ACTIVE AND PASSIVE TOXICOVIGILANCE SCHEME FOR PESTICIDE POISONING IN WILDLIFE. P. Berny (1), O. Mastain

(2), A. Decors (2), V. Poulsen (3), M. Moinet (3), C. Dunoyer (4). (1) VetAgro-Sup, Marcy L’étoile, France; (2) ONCFS, Le Perray En Yvelines Cedex, France; (3) AFSSA, Maisons-Alfort Cedex, France;(4) FNC, Issy Les Moulineaux Cedex, France

P308-033ENANTIOSEPARATION OF METHAMIDOPHOS BY HPLC-UV USING POLYSACCHARIDE CHIRAL STATIONARY PHASE. G. L. Emerick (1), R. V. Oliveira (2), K. R. Belaz (2), G. H. Deoliveira (1). (1) Sao Paulo State University, Araraquara, Brazil; (2) Universidade Federal de São Carlos, Sao Carlos, Brazil

P308-034RECENT GENETIC DAMAGE IN A PESTICIDE-EXPOSED POPULATION: COMET ASSAY AND MICRONUCLEI IN RETICULOCYTES. C. Costa (1), S. Silva (1), P. Coelho (1), S. Costa (1), J. Neves (1), B. Johnson (2), O. Mayan (1), J. Snawder (2), J. P. Teixeira (1). (1) Portuguese National Institute of Health, Porto, Portugal; (2) National Institute for Occupational Safety and Health, US Centers for Disease Control and Prevention, Portugal

P308-035ADAPTIVE RESPONSE OF SACCHAROMYCES CEREVISIAE UE-ME3 TO ISOPROTURON DEPENDS ON THE PRESENCE OF PEPTONE IN THE RICH CULTURE MEDIUM. M. Candeias (1), I. Alves-Pereira (2), R. Ferreira (2). (1) Dep. Química, Escola de Ciências e Tecnologia, Universidade de Évora, Évora, Portugal; (2) Dep de Química, Escola de Ciências e Tecnologia, Instituto de Ciências Agrárias e Ambientais, Centro de Tecnologia Animal (ICAAM-CTA), Universidade de Évora, Portugal, Évora, Portugal

P308-036ORGANOPHOSPHORUS (OP)-HYDROLYZING ENZYMES IN OP ANTAGONISM: CHOLINESTERASE INHIBITION AS INDICATOR OF OP INTOXICATION. I. Petrikovics (1), J. Wild (2), R. Kern (2), M. Wales (2). (1) Sam Houston State University, Huntsville, United States; (2) Texas A&M University, College Station, United States

P308-037EFFECTS OF CURRENTLY USED PESTICIDES ON ESTROGEN AND THYROID HORMONE FUNCTION IN VITRO. M. Ghisari, L. Kjeldsen, E. C. Bonefeld-Jorgensen.Center of Arctic Medicine, School of Public Health, University of Aarhus, Aarhus C, Denmark

P308-038EXPRESSION OF HEAT SHOCK PROTEIN 90 IN PERMETHRIN INDUCED NEUROTOXICITY. D. Guvenc, A. Aksoy, E. Atmaca, Y. B. Kabak, T. Guvenc. Faculty of Veterinary Medicine, Samsun, Turkey

P308-039TIME TRENDS AND FACTORS INFLUENCING SURVIVAL FOLLOWING PARAQUAT INGESTION IN SRI LANKA. M. Wilks (1), R. Fernando (2), P. Ariyananda (3), D. Berry

(4), J. Tomenson (5), N. Buckley (6), I. Gawarammana (7), S. Jayamanne (8), D. Gunnell (9), A. Dawson (7). (1) Swiss Centre for Applied Human Toxicology, Basel, Switzerland; (2) University of Colombo; (3) University of Ruhuna; (4) Syngenta; (5) Causation Ltd; (6) University of New South Wales; (7) South Asian Clinical Toxicology Research Collaboration; (8) Polonnaruwa Base Hospital; (9) University of Bristol,

P308-040THE EFFECT OF DIAZINON ON NA+/K+-ATPASE ACTIVITY. D. Krstić (1), M. Čolović (2), A. Leskovac (2), V. Vasić (2). (1) School of medicine, Belgrade University, Belgrade, Serbia; (2)

Vinča Institute of Nuclear Sciences,Belgrade,

P308-041SINGLE LABORATORY VALIDATION AND UNCERTAINTY ESTIMATION OF MULTIRESIDUES METHOD FOR DETERMINATION OF PESTICIDES IN VEGETABLES AND FRUITS BY USING QUECHERS SAMPLE EXTRACTION AND GC-MS. M. Nocentini, C. Focardi, M. Fortini. IZSLT, Florence, Italy

P308-042DETERMINATION OF PESTICIDE RESIDES CONCENTRATION IN WATER OF GHARESOU RIVER. P. Moghaddam (1), F. Hosseini Behbahani (2), Z. Nazari Khorasgani (3). (1)

Dept. of Chemical Engineering, College of Technical and Engineering, Islamic Azad University North Tehran Branch, Islamic Republic of Iran, Tehran, Iran (Islamic Republic of); (2) Lab of Khouzestan Legal Medical Organization,Ahvaz, Islamic Republic of Iran; (3) Dept. of Toxicology & Pharmacology, Pharmacy School, Ahvaz Jundishapour University of Medical Sciences Ahvaz, Islamic Republic of Iran,

P308-043THE INFLUENCE OF DIAZINON AND ITS PHOTOINDUCED BY-PRODUCTS ON ACHE ACTIVITY. M. Čolović (1), D. Krstić (2), S. Petrović (1), V. Vasić (1). (1) Institut za nuklearne nauke “Vinča”,, Belgrade, Serbia; (2) School of Medicine, University of Belgrade,

BARCELONAIUTOX 2010


89

P308-044SUBACUTE TOXICITY OF THE HERBICIDE GAL-57 (BENTAZON+DICAMBA) TO RATS. D. Brkic (1), S. Gasic (1), I. Szakonyne Pasics (2), L. Radivojevic (1), V. Karan (2), N. Neskovic (1). (1) Institute of Pesticides and Environmental Protection, Belgrade-Zemun, Serbia; (2) , Dunakeszi, Hungary

P308-045PHARMACOKINETICS OF DIMETHOATE POISONING IN THE MINIPIG. IS THIS A USEFUL MODEL FOR HUMAN EXPOSURE? J. Anderson (1), K. Petersson (2), L. Friburg

(2), M. Eddleston (3), R. Clutton (3), F. Worek (4), H. Thiermann (4), N. Buckley (1). (1) South Asian Clinical Toxicology Research Collaboration, Sri Lanka & University of NSW, Sydney, Australia; (2) Pharmacometrics Department Uppsala University; (3) University of Edinburgh, UK; (4) Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany

P308-046APOPTOSIS OF PERIPHERAL BLOOD MONONUCLEAR CELLS IN CHILDREN EXPOSED TO DDT AND ITS METABOLITES. I. N. Perez Maldonado, F. J. Perez Vazquez, O. Gaspar-Ramirez, F. Diaz-Barriga. Universidad Autónoma De San Luis Potosi, San Luis Potosi, México.

P308-047THE ENVIRONMENTAL HEALTH AND CONTAMINANTS IN SOUTH AFRICA. H. B. Röllin (1), J. Ø. Odland (1), T. M. Sandanger (2). (1) South African Medical Research Council, Houghton, South Africa; (2) ,

P308-048MECHANISM OF COMBINED EFFECT OF 2,4-D AND MERCURY METHYL. V. Rakitskiy (1), T. Sinitskaya (2). (1) Federal Research Center for Hygiene named after F.F.Erisman, Moscow, Russian Federation; (2) The Federal Research Center for Hygiene named after F.F.Erisman

P308-055IMMUNOTOXIC EFFECTS WITHIN THYMUS INDUCED BY IN UTERO AND LACTATIONAL EXPOSURE TO ENDOSULFAN IN ADULT RATS. A. Caride, T. Cabaleiro, A. Lafuente. University of Vigo, ORENSE, Spain

P308-056GENOTOXIC EFFECTS OF ENDOSULFAN ON GH AND TSH: POSSIBLE IMPLICATIONS OF VARIATIONS ON REDOX BALANCE. A. Lafuente, A. Caride, T. Cabaleiro. University of Vigo, Orense, Spain

P309: FOOD SAFETY

P309-001HEAVY METAL (PB, CD) AND METALLOID (AS) CONTENT IN SPANISH RED WINES WITH CERTIFIED BRAND OF ORIGIN. M. Pérez-López (1), G. García Rodríguez (2), D. Hernández-Moreno (1), F. Soler (1). (1) University of Extremadura, Caceres, Spain; (2) Servicio Extremeño de Salud (SES), Talaván, Spain P309-002JOJOBA EXTRACT COUNTERACTS OXIDATIVE STRESS IN RATS FED FUMONISIN-CONTAMINATED DIET. M. Abdel-Wahhab (1), H. Sharaf (2), F. Abou-Salem3 (2). (1) Food Toxicology & Contaminants Department, National Research Center, Cairo, Egypt: (2) ,

P309-003EXPOSURE TO DIOXIN-LIKE CARCINOGENS OF THE POPULATION OF THE CANARY ISLANDS (SPAIN) THROUGH THE INTAKE OF DAIRY PRODUCTS. M. Almeida-González, M. Zumbado, O. P. Luzardo, L. D. Boada. University of Las Palmas de Gran Canaria and Instituto Canario de Investigación del Cáncer, Las Palmas de Gran Canaria, Spain

P309-004SACCHAROMYCES CERVISIAE AND LACTOBACILLUS RHAMNOSUS POTENTIALLY INHIBIT AFLATOXINS PRODUCTION IN VITRO AND IN VIVO STUDIES. H. Amra, S. Nada, E. Omara, E. El –damaty, G. Rowayshed, M. Deabes. National Research center, Cairo, Egypt

P309-005A SUBCHRONIC ORAL TOXICITY STUDY OF ALMOND SKINS IN RATS. Y. Song. Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China

P309-006DETERMINATION OF HEAVY METALS LEVELS IN IMPORTED RICE AT MARKETS OF AHVAZ CITY. A. Hosseini (1), A. Behfar (2), Z. Nazari Khorasgani (1), R. Ebrahimi (1). (1) Dept. of toxicology & Pharmacology,Pharmacy school, Ahvaz Jondishapour University of Medical sciences, Ahvaz,Khuzestan, Islamic Republic of Iran, Ahvaz, Iran (Islamic Republic of); (2) Department of Food Science and Medical Hydrology, Pharmacy School, Ahvaz Jondishapour University of Medical Sciences, Ahvaz, Khouzestan, Islamic Republic of Iran,

P309-007DETERMINATION OF AFLATOXINS LEVELS IN IMPORTED RICE AT MARKETS OF AHVAZ CITY. R. Ebrahimi (1), A. Behfar (2), Z. Nazari Khorasgani (1), A. Hosseini (1). (1) Department of Toxicology & Pharmacology, Pharmacy School, Ahvaz Jondishapour University of Medical Sciences, Ahvaz, Khouzestan, Islamic Republic of Iran, Ahvaz, Iran (Islamic Republic of); (2) Department of Food Science and Medical Hydrology, Pharmacy School, Ahvaz Jondishapour University of Medical Sciences, Ahvaz, Khouzestan, Islamic Republic of Iran,

P309-008DETERMINATION OF AFLATOXIN M1 CONTAMINATION LEVELS IN PRODUCED PASTEURISED MILK MANUFACTORY IN AHVAZ CITY BY HPLC. A. Behfar (1), Z. Nazari Khorasgani (2), Z. Alemzadeh (1), R. Ebrahimi (2), N. Tarhani (1). A. Behfar (1), Z. Nazari Khorasgani (2), Z. Alemzadeh (1), R. Ebrahimi (2), N. Tarhani (1). (1) Department of Food Science and Medical Hydrology, Pharmacy School, Ahvaz Jondishapour University of Medical Sciences, Ahvaz, Khouzestan, Islamic Republic of Iran, Ahvaz, Iran (Islamic Republic of); (2) Department of Toxicology & Pharmacology, Pharmacy School, Ahvaz Jondishapour University of Medical Sciences, Ahvaz, Khouzestan, Islamic Republic of Iran,

P309-009DETERMINATION OF ACRYLAMIDE CONCENTRATION IN SOME DOMESTIC POTATO PRODUCT. M. T. Boroushaki (1), E. Nikkhah (2), M. Oskooei (3). (1) Mashhad University of Medical Sciences, Mashhad, Iran (Islamic Republic of); (2) Food and Hygienic Control Dept, Mashhad, Iran (Islamic Republic of); (3) Beh Ara Food Industrial Company, Mashhad, Iran (Islamic Republic of)

P309-010DETERMINATION OF ACRYLAMIDE CONCENTRATION IN SOME DOMESTIC CORN PRODUCTS. E. Nikkhah (1), M. T. Boroushaki (1), A. Kazemi (2). (1) Mashhad University of Medical sciences, Mashhad, Iran (Islamic Republic of); (2) Dina Food Industrial group, Mashhad, Iran,


90

P309-011HISTOPATHOLOGICAL, HAEMATOLOGICAL AND BIOCHEMICAL EFFECTS OF E341 (FOOD ADDITIVE) INDUCED MATERNAL TOXICITY IN RATS. A. Kılıç, C. Güngörmüş, D. Kolankaya, M. T. Akay. University of Hacettepe, Ankara, Turkey

P309-012DETERMINATION OF PATULIN CONTAMINATION LEVELS IN PRODUCED APPLE JUICE OF AHVAZ MANUFACTORY BY HPLC. Z. Nazari Khorasgani, A. Jalali, A. Hossieni, M. Gudarzi. Department of Toxicology & Pharmacology, Pharmacy School, Ahvaz Jondishapour University of Medical Sciences, Ahvaz, Khouzestan, Islamic Republic of Iran, Ahvaz, Iran (Islamic Republic of)

P309-013SAFETY ASSESSMENT OF ALMOND SKINS. Y. Song, X. Jia, X. Zhang, N. Li. Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China

P309-014EFFECTS OF SELENIUM SUPPLEMENTATION ON LIPID PEROXIDATION INDUCED BY THERMALLY OXIDIZED SUNFLOWER OIL. A. Rajaeefard (1), N. Tabatabaei (1), J. Jamalian (2), R. Ramezani (2), A. A. Owji (2), N. Karbalaie (2). (1) Shiraz School of Health and Nutrition, Shiraz, Iran (Islamic Republic of); (2) ,

P309-015TRANSCELLULAR TRANSPORT OF DOMOIC ACID IN CACO-2 CELL MONOLAYERS. T. Endo (1), O. Kimura (1), Y. Kotaki (2), N. Hamaue (1), K. Haraguchi (3). (1) Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan (2) Kitasato University, Japan (3) Daiich College of Pharmaceutical Sciences, Japan

P309-016APPLICATION OF THE THRESHOLD OF TOXICOLOGICAL CONCERN-CONCEPT IN SAFETY ASSESSMENT OF CHEMICALLY COMPLEX FOOD MATRICES. M. Rennen, S. Koster, C. Krul, L. Krul, G. Houben. TNO Quality of Life, Zeist, Netherlands

P309-017DETERMINATION OF FURAN LEVELS IN SELECTED FOODS IN BRAZIL. A. Arisseto, E. Vicente, M. Ueno, M. C. Toledo. Institute of Food Technology, Campinas, Brazil

P309-018SAFETY ASSESSMENT OF THE CORDYCEPS MILITARIS FRUITBODY. J. Huang. Centers for Disease Control and Prevention of Guangdong Province, Guangzhou, China

P309-019EVALUTATION OF THE BISFENOL-A GONADAL TOXIC EFFECT BY HYSTOPATHOLOGICAL STUDY IN ZEBRAFISH (DANIO RERIO). A. Lora (1), A. Molina (1), A. Jos (2), R. Fernandez (1), J. Monterde (1), A. Blanco (1), R. Moyano (1). (1) University of Córdoba, Córdoba, Spain; (2) University of Sevilla, Sevilla, Spain

P309-020ACUTE ORAL TOXICITY OF FUSARIUM-MYCOTOXIN MONILIFORMIN. M. Jestoi, M. Jonsson, P. Koivisto, R. Heinonen, A. Isoniemi, U. M. Kokkonen, M. Anttila, K. Peltonen. Finnish Food Safety Authority (Evira), Helsinki, Finland

P309-021DETERMINATION OF CALCIUM, MAGNESIUM, LEAD AND ARSENIC IN SALES AND REFINED UNREFINED BROKEN FOR HUMAN CONSUMPTION IN BOGOTA. N. Patiño Reyes, A. E. Bonilla Grande. Laboratorio de Toxicologia Secretaria Distrital de Salud de Bogota, Bogota, Colombia

P309-022DANTROLENE, A RYANODINE RECEPTOR 1 INHIBITOR, MITIGATES FUSARIUM MYCOTOXIN NIVALENOL-CAUSED CYTOTOXICITY IN HL60 CELLS. H. Nagashima, M. Kushiro, H. Nakagawa. National Food Research Institute, NARO, Tsukuba, Japan

P309-023PROTEIN PHOSPHATASE AND CELL-BASED ASSAYS AS TOXICOSURVEILLANCE TOOLS: MATRIX EFFECTS IN THE ANALYSIS OF MARINE TOXINS PRESENT IN SHELLFISH. H. Eixarch, D. Garibo, E. Cañete, P. De La Iglesia, M. Fernandez, J. Diogène, M. Campàs. IRTA, Sant Carles de la Ràpita, Spain

P309-025HISTOPATHOLOGY IS AN HIGH SENSITIVE BIOLOGICAL SCREENING METHOD TO DETECT ILLEGAL USE OF 17 BETA ESTRADIOL AS GROWTH PROMOTER IN FOOD PRODUCING ANIMALS. E. Bozzetta, M. Pezzolato, K. Varello, L. Borlatto, M. C. Abete, C. Maurella, M. Caramelli. Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d‘Aosta, TURIN, Italy

P309-026DETERMINATION OF DISINFECTION BY- PRODUCTS ( DBPS) IN FRESH CHIKEN AT RETAIL. A. Rubio (1), S. Navalon (2), M. Adelantado (2). (1) Centro de Salud Publica de Valencia, Valencia, Spain; (2) Universidad Politecnica de Valencia, Valencia, Spain

P309-027YESSOTOXIN CYTOTOXICITY ON RAT CARDIOMYOCYTES PRIMARY CULTURES. V. Dell’ovo (1), C. Florio (1), G. Decorti (1), P. Lorenzon (1), M. Sciancalepore (1), T. Yasumoto (2), E. Bracco (1), T. Coslovich (1), E. Bandi (1), A. Tubaro (1). (1) University of Trieste, Italy, Udine, Italy; (2) Japan Food Research Laboratories, 6-11-10, Nagayama, Tama-shi, Tokyo, Japan,

P309-028PESTICIDE RESIDUE ASSESSMENT OF ORGANICALLY CULTIVATED GREEK VIRGIN OLIVE OIL, DURING 2009. I. Tsakiris (1), C. Favas (2), A. Tsatsakis (3), M. Kokkinakis (3), M. Mparbounis (3), A. Kokkinaki (3). (1) Department Of Agricultural Products Marketing And Quality Control, Tei Of Western Macedonia, Florina Branch, Edessa, Greece; (2) Biohellas S.A., Inspection Department, Athens, Greece; (3) Medical School, University Of Crete, Laboratory Of Toxicology, Heraklion, Greece P309-029FREQUENCY AND SEVERITY ESTIMATION OF PESTICIDE RESIDUES FROM ORGANICALLY CULTIVATED OLIVES AND OLIVE TREE LEAFS IN GREECE, DURING 2008. I. Tsakiris (1), C. Favas (2), A. Tsatsakis (3), A. Alegkakis (3), P. Mitliagka (1), F. Papathanasiou (1), N. Niklis (1). (1) Department Of Agricultural Products Marketing And Quality Control, Tei Of Western Macedonia, Florina Branch, Florina, Greece; (2) Biohellas S.A, Inspection Department, Athens, Greece; (3) Medical School, University Of Crete, Laboratory Of Toxicology, Heraklion, Greece

P309-030INFLUENCE OF FOOD CONSUMPTION ON THE PHARMACOKINETIC PROFILE OF CATECHINS FROM A GREEN TEA-BASED BEVERAGE. S. O’hagan, H. Langley, M. Rowson. Unilever, Bedford, United Kingdom

P309-031ORGANOCHLORINE PESTICIDE AND POLYCHLORINATED BIPHENYLS LEVELS IN FISH AND MUSSEL IN VAN REGION, TURKEY. A. Aksoy (1), Y. K. Das (1), O. Yavuz (1), D. Guvenc (1), E. Atmaca (1), S. Agaoglu (2). (1) Ondokuz Mayis University, Samsun, Turkey (2) Yuzuncu Yil University,

BARCELONAIUTOX 2010


91

P309-032ESTIMATION OF INDICATOR PCBS INTAKE BY FRESHWATER FISH CONSUMPTION. B. Radosevic (1), V. Milovanovic (1), M. Curcic (1), B. Antonijevic (1), S. Jankovic (2), T. Radicevic (2), S. Stefanovic (2). (1) University of Belgrade, Faculty of Pharmacy, Belgrade, Serbia; (2) Institute of Meat Hygiene and Technology,

P309-033DEVELOPMENT OF IMMUNODIAGNOSTIC STRIP TESTS FOR MYCOTOXIN SCREENING OF FOOD AND FEED. B. Cvak (1), A. Molinelli (1), R. Krska (2). (1) Romer Labs Division Holding GmbH, Tulln, Austria; (2) Department for Agrobiotechnology, IFA Tulln, University of Natural Resources and Applied Life Sciences, Vienna,

P309-034SEASONAL VARIATION OF POLYCHLORINATED BIPHENYLS AND ORGANOCHLORINE PESTICIDE LEVELS OF SEA AND CULTURED FARM FISH IN SAMSUN REGION, TURKEY. A. Aksoy, D. Guvenc, O. Yavuz, Y. K. Das, E. Atmaca. Ondokuz Mayis University Veterinary Medicine Faculty, Samsun, Turkey

P309-035EFFECTS OF CHINESE WILD RICE ON THE LIPID METABOLISM AND LIPOTOXICITY IN RATS FED WITH HIGH CHOLESTEROL DIETS. P. Cao (1), C. K. Zhai (2), H. Zhang

(2), H. B. Xu (1), Y. H. Zhou (1). (1) National Institute for Nutrition and Food Satey,Chinese Center for Disease Control and Prevention, Beijing, China; (2) School of Public Health , Southeast University, Nanjing, China P309-036USE OF CACO-2 CELLS BASED CULTURE SYSTEMS FOR IMPROVED BENEFIT/RISK ASSESSMENT IN HUMAN FOOD. Y. J. Schneider, I. Dupont, G. Nollevaux, A. Bazes, J. Van De Walle, P. Pluvinage, T. Sergent. Institut des Sciences de la Vie & UCLouvain, Louvain-la-Neuve, Belgium

P309-037EFFECT OF A COCOA POLYPHENOL-ENRICHED EXTRACT IN CELLS TREATED WITH AFLATOXIN B1 AND OCHRATOXIN A. L. A. Corcuera (1), A. Hernando (1), L. Arbillaga

(1), S. Amézqueta (1), J. L. Torres (2), A. López De Cerain (1). (1) University of Navarra, Pamplona, Spain; (2) IQAC-CSIC,

P309-038TOXICOKINETIC STUDY OF AFLATOXIN B1 AND OCHRATOXIN A SIMULTANEOUSLY ADMINISTERED TO FISHER RATS. L. Corcuera, M. Ibañez-Vea, A. Vettorazzi, E. González-Peñas, A. López De Cerain. University of Navarra, Pamplona, Spain

P309-039RISK ASSESSMENT OF SHELLFISH CONTAMINATED BY HEAVY METALS AND PARALYTIC SHELLFISH POISON (PSP) IN VIETNAM.. D. Parent-Massin (1), A. Nguyen T

(2), T. L. Tran (2), F. G. Carpentier (1), A.C. Roud0t (1). (1) University of West Brittany (FRANCE), BREST, France; (2) NHA Trang University (Vietnam), Nha Trang, Viet Nam

P309-040RELEVANCE OF THE GENDER, AGE AND FASTING CONDITIONS IN OCHRATOXIN A KINETICS. A. Vettorazzi, E. González-Peñas, I. F. Trocóniz, L. Arbillaga, L. A. Corcuera, A. G. Gil, A. López De Cerain. Universidad de Navarra, Pamplona, Spain

P309-041DETERMINATION OF CALCIUM, MAGNESIUM, LEAD AND ARSENIC IN SALT, REFINED AND UNREFINED FOR HUMAN CONSUMPTION IN BOGOTA. P. R. Nancy, B. G. Ana Elvira. Secretaria Distrital de Salud de Bogota, Bogota, Colombia

P309-042AFLATOXIN PRODUCCTION FOR TWO MEXICAN STRAINS OF ASPERGUILLUS FLAVUS IN IMMATURE CORN GRAINS. A. G. Valdivia Flores (1), R. Ortiz Martínez (1), T. Quezada Tristán (1), M. C. De Luna López (1), A. Martínez De Anda (1), E. Moreno Martínez (2). (1) Universidad Autónoma de Aguascalientes, Aguascalientes, Mexico; (2) Universidad Nacional Autónoma de México, P309-043LEVELS OF TOXIC AND ESSENTIAL ELEMENTS IN MYTILUS EDULIS FROM SAN JORGE GULF, PATAGONIA ARGENTINA. A. A. Pérez (1), L. B. Pérez (1), A. M. Strobl (1), S. Camarda (1), M. Souto (1), S. S. Farias (2), G. M. Ponce (1), M. A. Fajardo (1). (1) Universidad Nacional de la Patagonia San Juan Bosco, Comodoro Rivadavia, Argentina; (2) Comisión Nacional de Energía Atómica, Gerencia de Tecnología y Medio Ambiente (CNEA),

P309-044ASSESSMENT OF SANITATION OF TRADITIONAL COCONUT SUGAR IN SAMUT SONGKRAM PROVINCE, THAILAND. J. Prakobsil, W. Benjabong, A. Nitithamyong, R. Tavichatwitayakul, W. Karnpanit, N. Moungsrichan, K. Singsoong. Institute of Nutrition, Mahidol university, Bangkok, Thailand

P309-045PRESERVATIVES USED IN COCONUT SAP. K. Singsoong, W. Benjapong, A. Nitithamyong, R. Tavichatwitayakul, W. Karnpanit, N. Moungsrichan, Prakobsil. Institute of Nutrition,Mahidol University, Bangkok, Thailand

P309-046NITRATE, LEAD AND CADMIUM CONTENTS IN BEANS, LEAFY, FRUIT AND ROOT VEGETABLES FROM CONVENTIONAL, GOOD AGRICULTURAL PRACTICE AND ORGANIC CULTIVATIONS. W. Karnpanit, W. Benjapong, S. Srianujata, N. Dhananiveskul, A. Poowanasatien, C. Jatutipsompol. Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand

P309-047SIMULTANEOUS DETERMINATION OF EIGHT BIOGENIC AMINES IN FISH BY LIQUID CHROMATOGRAPHY WITH FLUORESCENCE DETECTOR AND TANDEM MASS SPECTROMETRY. M. Fernández-Franzón (1), F. De Berardinis (2), G. Sagratini (2), S. Vittori (2), G. Font (1), J. Mañes (1). (1) Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy,University of Valencia, Burjassot,, Spain; (2) Dipartimento di Scienze Chimiche, Facoltà di Farmacia, Università degli Studi di Camerino, Camerino (MC), Italy

P309-048DEOXYNIVALENOL AND FUSARIUM SPECIES PRESENCE IN RAW MATERIALS FOR ANIMAL FEED. F. Caloni (1), C. Cortinovis (1), M. Pasquali (2), F. Giraud (2), A. C. Gutleb (2). (1) Università degli Studi di Milano, Department of Veterinary Sciences and Technologies for Food Safety Via Celoria 10 20133 Milan, Italy, Milan, Italy; (2) Centre de Recherche Public – Gabriel Lippmann, Belvaux, Luxemburg,

P309-049MULTIRESIDUE ANALYSIS OF PESTICIDES IN POLLEN BY PRESSURIZED LIQUID EXTRACTION AND GAS CHROMATOGRAPHY MASS SPECTROMETRY. H. Berrada

(1), C. Juan (2), G. Font (1). (1) Universidad de Valencia, Burjassot, Spain; (2) Centro Superior de Investigaciones en Salud Pública, Valencia, Spain

P309-050DEVELOPMENT AND VALIDATION OF A LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY METHOD FOR THE ANALYSIS OF MACROLIDES IN HONEY. H. Berrada (1), C. Juan (2), C. Igualada (2), G. Font (1). (1) Universidad Valencia, Burjassot, Spain; (2) 2Centro Superior de Investigaciones en Salud Pública, Generalitat Valenciana. Valencia, Spain


92

P309-051OCCURRENCE OF OCHRATOXIN A IN FOODS COMMONLY CONSUMED IN TURKEY. S. Ozden, A. S. Akdeniz, B. Alpertunga. Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Istanbul, Turkey, Istanbul, Turkey

P309-052OCCURRENCE OF FURAN IN BRAZILIAN SOY SAUCE - SHOYU. E. Vicente, A. P. Arisseto, M. C. F. Toledo, M. S. Ueno. Food Technology Institute - ITAL, Campinas, Brazil

P309-053BIOACCESSIBILITY AND BIOAVAILABILITY OF THE ENNIATINS A, A1, B, B1 CONTAINED IN A COMMERCIAL WHEAT CRISPY BREAD. G. Meca, M. J. Ruiz, J. Mañes, G. Font. University of Valencia, Faculty of Pharmacy, Burjassot, Spain P309-055FASTING STATUS AND THERMALLY OXIDISED SUNFLOWER OIL INGESTION AFFECT THE INTESTINAL GLUTATHIONE SYSTEM OF MALE WISTAR RATS. M. J. González Muñoz (1), R. Olivero David (1), F. J. Sánchez Muniz (2), S. Bastida (2), A. Schultz (2), L. González Torres (2), J. Benedi González (3). (1) Dpto. Nutrición, Bromatlogía y Toxicología. Facultad de Farmacia. Universidad de Alcalá, Alcalá de Henares, Spain; (2) Departamento de Nutrición. Facultad de Farmacia. Universidad Complutense de Madrid., Madrid, Spain; (3)

Departamento de Farmacología. Facultad de Farmacia. Universidad Complutense de Madrid., Madrid, Spain

P309-060ANTIMICROBIAL ACTIVITY OF ORIGANUM ONITES L. AND ORIGANUM MINUTIFLORUM O. SCHWARZ & P. H. DAVIS ESSENTIAL OILS. M. Odabasi (1), Y. Beyatli (2). (1) Institute of Forensic Medicine, Ankara University, Ankara, Turkey; (2) Department of Biology, Faculty of Science and Art, Gazi University,

P310: BIOTOXINS

P310-001PHYTOCHEMICAL AND TOXIC ANALYSIS OF AN ETHANOL EXTRACT FROM CEREUS JAMACARU. A. Schwarz (1), I. Medeiros (1), C. Mourão (1), F. Queiroz (1), S. Pflugmacher (2). (1) Universidade Federal do Rio Grande do Norte, Natal, Brazil; (2) Institute of Freshwater Ecology and Inland Fisheries – Berlin/Germany

P310-002CELL CYCLE ALTERATIONS AND APOPTOSIS ASSESSMENT IN SHSY5Y HUMAN NEUROBLASTOMA CELLS EXPOSED TO OKADAIC ACID. V. Valdiglesias, J. García-Lestón, E. Pásaro, J. Méndez, B. Laffon. University of A Coruña, A Coruña, Spain

P310-003AFLATOXIN M1 LEVELS IN BREAST MILK SAMPLES FROM ANKARA, TURKEY. A. Gürbay (1), S. Atasayar Sabuncuoğlu (1), G. Girgin (1), G. Şahin (1), Ş. Yiğit (2), M. Yurdakök

(2), G. Tekinalp (2). (1) Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey; (2) Hacettepe University, Faculty of Medicine, Department of Pediatrics, Section of Neonatology, Ankara, Turkey

P310-004BASAL CITOTOXICITY OF PURE CYLINDROSPERMOPSIN IN THE HUMAN CELL LINES CACO-2 AND HUVEC. S. Pichardo, D. Gutiérrez-Praena, A. Jos, A. M. Camean. Universidad de Sevilla, Sevilla, Spain

P310-005OXIDATIVE STRESS INDUCTION ON CACO-2 AND HUVEC CELL LINES BY PURE CYLINDROSPERMOPSIN. D. Gutierrez-Praena, S. Pichardo, A. Jos, A. M. Camean. University of Seville, Sevilla, Spain

P310-006OXIDATIVE STRESS INDUCED BY CYLINDROSPERMOPSIN IN KIDNEY OF TILAPIA FISH (OREOCHROMIS NILOTICUS). M. Puerto, S. Pichardo, A. Jos, A. M. Camean. University of Seville, Sevilla, Spain

P310-007OPTIMISATION OF THE EXTRACTION, PURIFICATION AND QUANTIFICATION OF CYLINDROSPERMOPSIN FROM DIFFERENT MATRICES. R. Guzman-Guillen, V. Rios, A. I. Prieto, I. M. Moreno, A. M. Camean. University of Seville, Sevilla, Spain

P310-008FUNGI AND AFLATOXINS CONTAMINATION IN NUTS IMPORTED TO SAUDIA ARABIA. M. Deabes. National Research Center, Cairo, Egypt

P310-009ETHNOBOTANICAL AND OBSERVATIONAL STUDY OF TOXIC PLANTS FOR BOVINES IN EASTERN PART OF COLOMBIA. M. C. Lozano, B. Doncel, C. Betancourt, C. Moreno. Universidad Nacional de Colombia, Bogotá, Colombia

P310-010CYTOTOXIC EFFECT OF PALYTOXIN ON HUMAN KERATINOCYTE AND COLERECTAL ADENOCARCINOMA CELLS. M. Pelin, C. Zanette, S. Sosa, C. Florio, A. Tubaro. Università degli Studi di Trieste, Trieste, Italy

P310-011ENZYMATIC AND ANTILEISHMANIAL ACTIVITIES OF FIVE REAR-FANGED SNAKE VENOMS. M. Peichoto (1), F. Tavares (1), G. Dekrey (2), S. Mackessy (2). (1) Universidad Nacional del Nordeste, Corrientes, Argentina; (2) ,

P310-012ACTIVITY OF GLUTATHIONE S-TRANSFERASE IN MYTILUS GALLOPROVINCIALIS AND CORBICULA FLUMINEA EXPOSED TO TOXIC CYLINDROSPERMOPSIS RACIBORSKII CELLS. A. I. Prieto (1), M. Puerto (1), A. Campos (2), A. M. Camean (1), V. Vasconcelos (2). (1) University of Seville, Seville, Spain; (2) University of Porto,

P310-013ANALYSIS OF GLUTATHIONE S-TRANSFERASE AND GLUTATHIONE PEROXIDASE IN THE RICE PLANT (ORYZA SATIVA L.) EXPOSED TO APHANIZOMENON OVALISPORUM AND MICROCYSTIS AERUGINOSA CELL EXTRACTS. A. I. Prieto (1), M. Puerto (1), A. Campos (2), A. M. Camean (1), V. Vasconcelos (2). (1) University of Seville, Sevilla, Spain; (2) University of Porto,

P310-014EFFECTS OF OCHRATOXIN A ON MICRONUCLEUS FREQUENCY IN HUMAN LYMPHOCYTES.. B. C. Liman. Univerity of Erciyes, Kayseri, Turkey

BARCELONAIUTOX 2010


93

P310-015TOXICITY OF PALYTOXIN AND 42-HYDROXY-PALYTOXIN ON CULTURED MOUSE SKELETAL MUSCLE CELLS. G. Del Favero (1), P. Lorenzon (1), C. Florio (1), S. Sosa (1), P. Ciminiello (2), E. Fattorusso (2), M. Poli (3), G. Bignami (4), A. Tubaro (1). (1) Università degli Studi di Trieste, Valle di Cadore, Italy; (2) Università di Napoli “Federico II”, Italy; (3) U.S. Army Medical Research Institute of Infectious Diseases, Italy;(4) PanThera Biopharma, Italy

P310-016IDENTIFICATION OF EMBRYOTOXIC EFFECTS OF THE MARINE BIOTOXIN OKADAIC ACID BY DIFFERENT MURINE EMBRYONIC STEM CELL TEST ASSAYS. A. Lampen, S. Stempin, R. Al-Hamwi, A. Ehlers. Federal Institute for Risk Assessment, Berlin, Germany

P311: EDUCATIONAL-TRAINING-PUBLICATION- SOCIAL ASPECTS

P311-001TEN YEARS OF THE INTERNATIONAL ONLINE MASTER IN TOXICOLOGY IN SPANISH. M. Repetto (1), G. Repetto (2). (1) University of Sevilla, Sevilla, Spain; (2) National Institute of Toxicology and Forensic Sciences and University Pablo de Olavide, Sevilla, Spain

P311-002THE WORLD LIBRARY OF TOXICOLOGY (WLT) - CONNECTING SCIENCE AND PEOPLE TO IMPROVE GLOBAL HEALTH. S. Gilbert (1), P. Wexler (2), E. Faustman (2), N. Thorp (1). (1) Institute of Neurotoxicology & Neurological Disorders (INND), Seattle, United States; (2) , Bethesda, United States P311-003HISTORICAL MILESTONES AND DISCOVERIES WHICH SHAPED THE TOXICOLOGY SCIENCES. S. Gilbert (1), A. Hayes (2). (1) Institute of Neurotoxicology & Neurological Disorders (INND), Seattle, United States; (2) Wyeth Pharmaceuticals, P311-004TOXIPEDIA - TOXICOLOGICAL INFORMATION IN THE CONTEXT OF HISTORY, SOCIETY, AND CULTURE. S. Gilbert, N. Thorp, M. Mergel. Institute of Neurotoxicology & Neurological Disorders (INND), Seattle, United States

P311-005METALS, ENVIRONMENT AND LIFE - INTERFERENCE OF VANADIUM IN LIVING SYSTEMS AND THEIR CONTEXTUALIZATION IN TEACHING EXPERIMENTAL SCIENCES. P. Ruivo (1), I. Alves-Pereira (2), R. Ferreira (2). (1) Escola Secundária Dom Manuel Martins, Setúbal, Dep de Química, Escola de Ciências e Tecnologia, Universidade de Évora, Portugal, Évora, Portugal; (2) Dep de Química, Escola de Ciências e Tecnologia, Universidade de Évora, Instituto de Ciências Agrárias e Ambientais, Centro de Tecnologia Animal (ICAAM-CTA), Universidade de Évora, Portugal, Évora, Portugal

P311-006ADMINISTRATION OF PROFESSIONALS RESPONSIBLE FOR MEDICINE WITHOUT PRESCRIPTION TO CHILDREN IN THE CITY OF SÃO GONÇALO OF EAST FLUMINENSE. F. C. Morone Pinto, A. De Assis Carias, A. Moreira Dos Santos, I. De Medeiros Bispo. Centro Universitário Celso Lisboa, Rio de Janeiro, Brazil

P311-007USE OF A SPREADSHEET TO SIMULATE A TOXICITY TEST AND ITS APPLICATION TO BIOASSAY DATA ANALYSIS TRAINING. M. I. Arufe (1), J. M. Arellano (1), M. J. Moreno (2). (1) Faculty of Marine and Environmental Sciences. University of Cádiz, Puerto Real, Spain; (2) Faculty of Sciences. University of Cádiz,

P311-008TOXICOLOGICAL RESEARCH IN ESTONIA. A. Kahru. National Institute of Chemical Physics and Biophysics; Estonian Society of Toxicology, Tallinn, Estonia

P311-010DOES UROD WITH INHALATION ANESTHESIA IS BETTER THAN INTRAVENOUS ANESTHESIA? B. Mostafazadeh (1), P. Afsharian (2). (1) Shaheed Beheshty University of Medical Sciences, Tehran, Iran (Islamic Republic of); (2) Private physician, Tehran, Iran (Islamic Republic of)

P311-011LEVEL OF UNDERSTANDING OF FIRST AID INFORMATION CONTAINED IN AGROCHEMICAL LABELS BY TOMATO GROWING TENANT FARMERS IN SUMARÉ, SP. C. Tomazin, F. Zambrone. PLANITOX, SUMARE, Brazil

P311-012DRUGS POISONINGS IN THE ELDERLY. D. Chaparoska. University Clinical Centre, Skopje, Macedonia


94

EXHIBITION AREA

BARCELONAIUTOX 2010


95

1 PREVOR

2 MESO-SCALE DISCOVERY

3 LGC STANDARDS, S.L.U.

4 EUROPEAN COMMISSION RESEARCH

DIRECTORATE-GENERAL

5 SKINETHIC

6-7 PDS AND METTLER TOLEDO

8 CXR BIOSCIENCES LTD.

9 LAB RESEARCH A/S

10 NOTOX B.V.

11 BIONAS GMBH

12 PERCEPTIVE INSTRUMENTS LTD

13 SDS DIETEX

14 MARSHALL BIORESOURCES

15-16 MPI RESEARCH

17 INSTEM

18-19 ALERE INTERNATIONAL

20 TUPI MANUFACTURING

21-22 RTC S.P.A.

23 ILSI EUROPE

24 SOT

25 AETOX

26 IUTOX

27 EUROTOX 2011

28 VITROCELL SYSTEMS GMBH

29-30 ELSEVIER

31 LEADSCOPE INC.

32-33 EFSA EUROPEAN FOOD SAFETY AUTHORITY

34 XENOMETRIX AG

35 BIOPORTO DIAGNOSTICS

36 CHARLES RIVER

37 ORGANIZATION

38 TRINOVA

39-44 CIT

40 CULTEX LABORATORIES GMBH

41 BIOVENDOR-LABORATORNI MEDICINA A.S.

42 NAL VON MINDEN GMBH

43 PHYSIOSTIM

45 THE NATIONAL LIBRARY OF MEDICINE

46 SNBL

47 PANLAB

48 EXPOQUIMIA

49 MERCK CHEMICALS LTD

50 TSE SYSTEMS GMBH

51 ADVANCELL IN VITRO CELL TECHNOLOGIES, S.A.

52-53 HARLAN LABORATORIES LTD.

54 BIOBIDE S.L.

55 AAALAC INTERNATIONAL

56 HUNTINGDON LIFE SCIENCES

57 INSTITUTE FOR IN VITRO SCIENCES

58 VIVOTECNIA

59 ELLEGAARD GÖTTINGEN MINIPIGS A/S

60 ORGANIZATION

61 ACCELERA SRL

62 EXPUB, A DIVISION OF EBSCO PUBLISHING

63 JRF INTERNATIONAL

64 ROCHE DIAGNOSTICS GMBH

65 PORSOLT & PARTNERS PHARMACOLOGY

66 GENTRONIX

67 BASF SE

68 JOHN WILEY & SONS LTD

69 EVOTEC UK LIMITED

70 LHASA LIMITED

EXHIBITORS


96

Get on the Right Track for your Preclinical Development!

Come and meet your key contactson booth no 39-44

6 scientific posters presented copies available on the booth

Join us for a drink served at 17:00each day on the booth

Phone +33 (0)2 32 29 26 26Fax +33 (0)2 32 67 87 05Email [email protected]

B.P. 563 - 27005 Evreux cedex, France

www.citox.com

40 yearsof expertise!

BARCELONAIUTOX 2010


97

SPONSORS LIST

Diamond Sponsors

EXPOQUIMIA – International Chemistry Trade Show

From Fira Barcelona will hold the most important appointment of applied chemistry in Europe during 2011.

Expoquimia, concentrated more than 1100 direct exhibitors and 55.000 of professional visitors.

Lab&Bio, as a sector of Expoquimia, is once again shining a spotlight on the companies that specialise in biotechnology and analytical instrumentation, two disciplines that are experiencing unprecedented growth. This dedicated area is where science, knowledge and business come together in support of one of the fastest-growing markets. Innovation and science at the service of industry.

In November 2011 (14-18th) thanks to all of you, we will transform Barcelona in the European Scientific Capital insouth europe.

HOLMSTEDT MEMORIAL FUND (BMHF)

Professor Bo Holmstedt was a prominent toxicologist, well-known in the international toxicology community for his out-standing research, engagement in education, contributions to toxicological organizations and role as a leading authority in toxicological evaluation. He contributed to many key areas of pharmacology and toxicology in a constructive and interdis-ciplinary way, and saw toxicology as an important medical discipline. Professor Holmstedt, a true scientist, worked relent-lessly to obtain recognition of toxicology in science, education and chemical regulation. To honor Professor Holmstedt, the BHMF, in collaboration with EUROTOX, funds lectures and travel fellowships, providing critical assistance to scientists living and working in developing countries.


98

Gold Sponsor

PROUS INSTITUTE FOR BIOMEDICAL RESEARCH

Parc Científic de Barcelona, Torre I Planta 7ª C/ Baldiri i Reixac, 4-6 08028 Barcelona Spain Telf: +34 934 571 [email protected] www.prousresearch.com

Prous Institute for Biomedical Research is a research company comprised actively involved in drug discovery and the develop-ment of in silico technologies. Prous Institute is committed to discovering novel therapies through its Epistemic Drug Discovery Program® (EDD). Prous Institute’s in silico technologies include chemoinformatic prediction technologies used for regulatory and industry safety screening programs and to speed up the process of drug discovery and development. Prous Instiute pres-ents BioEpisteme® , a quantitative structure-activity relationship (QSAR) software program that facilitates the creation of a wide variety of predictive models, including mechanisms of action, adverse events and toxicological endpoints.

TNO

Utrechtseweg 48 3704 HE ZEIST The Netherlands P: +31 30 694 42 73 [email protected] www.tno.nl/chemistry

When looking for a facility to professionally perform your toxicology and analytical chemistry studies, contact TNO.

TNO would be a partner not just to perform the studies, but to also discuss the choice of studies, their lay-out and the pos-sibility and availability of alternatives.

Challenge us by discussing your intended program with us.

For more information, please contact us: www.TNO.NL

Netherlands Japan GermanyUtrechtseweg 48 P +81 367 18 45 27 P +49 89 709 291 473704 HE Zeist F +81 804 06 98 787 F +49 89 709 292 67The Netherlands [email protected] [email protected] +31 30 694 42 73F +31 30 694 40 [email protected]

BARCELONAIUTOX 2010


99

Silver Sponsors

A.C.T (American College of Toxicology)

The mission of the American College of Toxicology (A.C.T) is to educate, lead and serve professionals in industry, govern-ment and academia by promoting the exchange of information and perspectives on safety assessment and the application of new developments related to toxicology. A.C.T.’s strategic objectives include focusing on the interdisciplinary exchange of scientific information, sponsoring scientific and educational programs, presenting the ideals of its membership, dissemi-nating information through its journal and newsletter, and serving in other capacities in which the College can function more efficiently as a group than as individuals.

ASTRAZENECA

AstraZeneca is a global, innovation-driven, integrated biopharmaceutical company. We discover, develop, manufacture and market prescription medicines for six important areas of healthcare, which include some of the world’s most serious illnesses: cancer, cardiovascular, gastrointestinal, infection, neuroscience, and respiratory and inflammation. AstraZeneca employs over 62,000 people (47% in Europe, 31% in the Americas and 22% in Asia, Africa and Australasia), and with over 11,000 people in its R&D organization, invests over $4 billion in R&D each year.

FERRER

LRI-CEFIC (Long Range Research Initiative - The European Chemical Industry Council)

NIEHS (National Institute of Environmental Health Sciences)

The National Institute of Environmental Health Sciences (NIEHS) is one of 27 research institutes and centers that comprise the National Institutes of Health (NIH). The mission of the NIEHS is to reduce the burden of human illness and disability by understanding how the environment influences the development and progression of human disease.

Since its establishment in 1966, NIEHS has evolved to its present status as a world leader in environmental health sciences, with an impressive record of important scientific accomplishments and a proud history of institutional achievements and growth.


100

SOT (Society of Toxicology USA)

1821 Michael Faraday Drive, Suite 300 Reston, VA 20190 USA T: 703.438-3115 F:703.438-3113 E-Mail: [email protected] Web site: www.toxicology.org

The Society of Toxicology (SOT) is the largest association of professional toxicologists in the world, with over 6500 mem-bers from more than 50 countries. Each year in March, the SOT holds an Annual Meeting and exposition that is attended by 6,000-7,000 scientists, features presentation of over 2400+ abstracts in a variety of session types, and showcases 400 exhibits of products and services.Members receive discounted registration fees for SOT meetings and the SOT journal, Toxicological Sciences, the premier peer-reviewed, hypothesis-driven publication of original research articles in toxicology. Stop by the booth to meet SOT leaders, get an update on plans for the SOT’s 50th Anniversary Meeting March 6-10, 2011 in Washington, DC, and learn about new programs for scientists from developing countries.

RICERCA BIOSCIENCES

Contact Address: 7528 Auburn Road; Concord, OH 44077Website: www.ricerca.comE-Mail: [email protected]

Ricerca Biosciences offers a comprehensive suite of discovery and preclinical services to support drug candidates from discovery through IND on a global scale, including capabilities in discovery and medicinal chemistry, API process chemistry, cGMP manufacturing and scale-up, IND-enabling toxicology, molecular profiling, pharmacology/DMPK and drug safety assessment services. With facilities in Concord, Ohio; Bothell, Washington; Taipei, Taiwan; and Lyon, France, Ricerca offers scientific excellence through reliable, cost-effective strategies to accelerate your drug discovery programs.

Bronze Sponsors

ALMIRALL S.A

General Mitre 151 08022 Barcelona - Spain www.almirall.com [email protected] About Almirall:Almirall, an international pharmaceutical company based on innovation and committed to health. Headquartered in Barcelona, Spain, researches, develops, manufactures and commercialises its own R&D and licensed drugs with the aim of improving people’s health and wellbeing.

The therapeutic areas on which Almirall focuses its research resources are related to the treatment of asthma, COPD (Chronic Obstructive Pulmonary Disease), rheumatoid arthritis, multiple sclerosis, psoriasis and other dermatological conditions.

Almirall’s products are currently present in over 70 countries while it has direct presence in Europe and Latin America through 11 affiliates.

For further information please visit the website at: www.almirall.com

BARCELONAIUTOX 2010


101

BIOGEN IDEC

JAPANESE SOCIETY OF TOXICOLOGY (JSOT)

The Japanese Society of Toxicology (JSOT) was first organized in 1975 by an ancestral study group, and has just hosted its 37th Annual Meeting in Okinawa. The members from academia, industrial and regulatory sectors, now add up to over 2,500. JSOT issues the Journal of Toxicological Sciences, runs the accreditation board Diplomate of the Japanese Society of Toxicology (D.J.S.T.), and comprises an important part of the toxicology society in Japan with the Japanese Society of Clinical Toxicology and the Japanese Society of Toxicologic Pathology. JSOT is a member of IUTOX and ASIATOX, and will host the ASIATOX-VI meeting in 2012 at Sendai.

TARGACEPT

Targacept is developing a diverse pipeline of innovative NNR Therapeutics™ for difficult-to-treat diseases and disorders of the nervous system. NNR Therapeutics selectively modulate the activity of specific neuronal nicotinic receptors, a unique class of proteins that regulate vital biological functions that are impaired in various disease states. Targacept’s lead program, TC-5214, is in Phase 3 development as an adjunct treatment for major depressive disorder. Targacept leverages its scientific leadership and proprietary drug discovery platform Pentad™ to generate novel small molecule product candidates to fuel its pipeline, and uses its expertise to create significant alliances with global pharmaceutical companies. Targacept is committed to Building Health and Restoring Independence™ for patients. For more information, please visit www.targacept.com.

SANOFI PASTEUR

GSK

PFIZER LIMITED

Contributors

ABBOTT LABORATORIES

AFFYMETRIX

ATS

CEETOX


102

CTDC7

EXXONMOBIL

JOHNSON & JOHNSON PHARMA R & D

GRADIENT CORPORATION

PFIZER GLOBAL RESEARCH AND DEVELOPMENT

PROCTOR & GAMBLE

WILEY-BLACKWELL

Exhibitors

AAALAC INTERNATIONAL Apartado de Correos 266, 31080 Pamplona, Spain www.aaalac.org [email protected] ; [email protected] Contact: Javier Guillen. Senior Director and Director of European Activities.

AAALAC International is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. AAALAC stands for the “Association for Assessment and Accreditation of Laboratory Animal Care.”

More than 800 companies, universities, hospitals, government agencies and other research institutions in 32 countries have earned AAALAC accreditation, demonstrating their commitment to responsible animal care and use.

BARCELONAIUTOX 2010


103

ACCELERA

Accelera Srl Viale Pasteur 10 Nerviano, Milano, Italy www.accelera.org [email protected]

Accelera is a premium tier CRO, working & collaborating with pharmaceutical & biotech companies around the world. From our unique history Accelera offers a unique range of integrated and tailored drug discovery & development services:

Full IND-enabling packages• Regulatory Toxicology (including NHP)• Biologics and Biomarkers• Safety Pharmacology• ADME/PK• Preclinical and Clinical bioanalysis• HTP Preclinical Profiling• Regulatory Consultancy•

Accelera is uniquely able to provide mainstream pharma capabilities and experience in response to your preclini-cal development needs, adding value to your products, reducing late attrition rates and improving cycle times. With Accelera, experience results.

ADVANCELL

Baldiri Reixac, 10-12 Barcelona Spain www.advancell.net [email protected]

Advancell is a biotechnology company with its own technology and continuous innovation; it délas with unresolved ques-tion in Elath and wellbeing using value adding, efficient products and services.

The Company is organized into three business Units:

Alternative Testing, which develops cell in vitro models to predict safety, efficacy and mechanism of action of melecules in development.

Nanosystems, uses natural polymer nanosystems to improve the delivery and administration of drugs and modulate their bioavailability.

Therapeutics, which focuses its activity on developing innovative drugs through development strategies that will enable them to reach the clinical stage efficiently, result-oriented in the search for new applications.


104

ALERE INTERNATIONAL

Rue des Vignerons 1A1110 MorgesSwitzerlandTel: 0041 21 80 4 71 40Email: [email protected]

Inverness Medical’s new global brand

We are a world leader in diagnostic products to assist laboratory and healthcare professionals in both preventative and inter-ventional medicine, providing qualitative and quantitative results. Our focus is in the broad clinical fields of Women’s Health, Oncology, Infectious Disease Cardiology and Drugs of Abuse.

Alere’s Drug of Abuse portfolio includes an expanding range of rapid tests for urine, oral fluid specimen and solid samples for hospital, laboratories, and point of care units or health centers, workplaces, government and criminal justice; from single testing to almost 20 drugs including sophisticated automatic readers.

BASF S.E.

APD/R, Li556, 67117 Limburgerhof / [email protected]

BIONAS GmbH

Friedrich-Barnewtitz-Straße 3 18119 Rostock Germany www.bionas.de [email protected]

Bionas® specializes in instruments and services for label-free, cell-based assays.

The B2500 analyzing system is a 6 channel system for the simultaneous monitoring of oxygen consumption, acidification and cellular impedance/adhesion. The instrument generates real-time data about the metabolic activity of cells, including regeneration effects. Adherent, primary or suspension cells can be analyzed for applications in toxicology, oncology, drug discovery.

The B9600 adcon reader is a versatile instrument for label-free monitoring of cellular impedance in 96 well format. It pro-vides real-time information about cell adhesion, proliferation, morphology etc. for high-throughput screening and laboratory research. GLP laboratory service is also available.http://www.bionas.de

BARCELONAIUTOX 2010


105

BIOBIDE S.L.

Parque Tecnológico de San Sebastián, Paseo Mikeletegi 58, bajo San Sebastián 20009 Spain

Biobide is a biotech company that aims to help our customers worldwide developing solutions to face their problems in the Drug Discovery process, integrating zebrafish animal model with innovative tools as High Content Screening based on our automation capability adding value to their R+D+i in the preclinical area.

Biobide helps companies decreasing withdrawals in the Drug Discovery and Development process, saving cost and time obtaining higher revenues from their investment. We are able to set up customized zebrafish toxicity, safety and efficacy assays, to ensure investing in the most successful drug candidates, due to their efficacy or safety.

BIOPORTO DIAGNOSTICS, A/S

Grusbakken, 8 2820 Gentofte Denmark Tel: +45 4529 0000 FAX: +45 4529 0001 www.bioporto.com www.ngal.com [email protected]

The primary focus for BioPorto Diagnostics is the new acute kidney injury marker, NGAL. NGAL is a biomarker that allows the early detection of kidney injury in drug safety studies in many animal models.

BioPorto Diagnostics offers a wide selection of NGAL antibodies and ELISA kits for laboratory animals that can be used in all phases of pharmaceutical development and basic research.

BioPorto Diagnostics’ product portfolio covers NGAL measurement in human, rat, mouse, monkey, dog and pig models - providing essential tools to study compound nephrotoxicity and drug safety in the pharmaceutical industry.

BIOVENDOR-LABORATORNI MEDICINA A.S.

BioVendor – Laboratorni Medicina a.s. established its Research and Diagnostic Products Division as an emerging innovative biotech company in the Czech Republic in 1995.

Our mission is to provide researchers and medical experts with top-quality immunodiagnostics and related biochemicals – monoclonal and polyclonal antibodies and recombinant proteins. BioVendor has become internationally recognized for its achievements in rapid launching of high-quality products – resulting in the development of biomarkers for early detection of obesity and obesity-related diseases associated with postindustrial societies. Our customers include the world’s top-ranking scientific institutions, pharmaceutical and biotech companies and clinical laboratories throughout more than 60 countries.


106

CHARLES RIVER

Tranent EH33 2NE UK Tel: + 44 1875 614545 [email protected] www.criver.com | accelerating drug development. exactly.

Focused on helping its global partners accelerate their research and drug development efforts, Charles River has provided high-quality research models and laboratory animal support expertise for more than 60 years, with an expanding portfolio of services to support discovery and imaging, preclinical and early-phase clinical studies, and biopharmaceutical and en-dotoxin products and services for manufacturing and quality control. Our unique portfolio spans the entire research and drug development process, from IND consultation to discovery through market approval, allowing flexible, customized ap-proaches to support both single-study or broad-based programs.

CIT

BP563 27005 Evreux France [email protected] www.citox.com

CIT is a leading European CRO specialised in pre-clinical and safety evaluation studies, located just one hour from Paris. Founded 40 years ago CIT works actively with pharmaceutical, biotech, chemical and agrochemical companies for product registrations and notifications.

CIT offers a full range of services: general toxicology in rodents and non-rodents including NHP, DART, carcinogenicity and safety pharmacology, genomics, genetic toxicology TCR/Immunhistochemistry, pharmacokinetics/DMPK and regulatory affairs.

With high quality and ethical standards CIT is fully GLP-compliant and is AAALAC accredited. Our 350-staff team includes 50 postgraduate scientists (DVM, PharmD, PhD) and is ready to help your upcoming developments.

CULTEX LABORATORIES GMBH

Feodor-Lynen-Str. 21 30625 Hannover Germany www.cultex-laboratories.com [email protected]

In the field of inhalation toxicology Cultex Laboratories GmbH is the platform for the in vitro analysis of airborne substances, such as particles, gases, volatile compounds and complex gas mixtures under realistic (in- and outdoor) atmospheric con-ditions. We developed a wide range of commercial available exposure systems, like the CULTEX® RFS module, especially designed for the direct exposure of cultivated cells to test atmospheres. Furthermore, we accept research and development contracts from the industrial as well as the public sector. Our consulting and planning services support both project planning and implementation.

BARCELONAIUTOX 2010


107

CXR BIOSCIENCES

www.cxrbiosciences.com [email protected], [email protected]

Summary information: CXR Biosciences Ltd. is commercialising innovative approaches to transform the drug development and chemical safety assessment process. As well as developing proprietary technology platforms such as stem cells and humanised mice, CXR also helps customers to take their candidate compounds through development efficiently, or to resolve problems that have been encountered, through the provision of customised solutions. The company has business relationships with many of the world’s leading pharmaceutical companies, chemical companies, biotechnology companies, universities and research institutions. CXR Biosciences Ltd. is located in Dundee, Scotland, UK.

ELLEGAARD GÖTTINGEN MINIPIGS A/S

Soroe Landevej 302 4261 Dalmose Denmark

Göttingen minipigs ® are accepted non-rodent models in pharmacology and toxicology. Studies performed on these minipigs are fully recognized by regulatory authorities worldwide, including FDA.

They should be considered, along with dogs and primates, when choosing the best non-rodent species for drug develop-ment and regulatory studies.

ELSEVIER

Radarweg 29, 1043 NX Amsterdam Name contact address J. Grondman-de Rijk, Website: www.elsevier.com e-mail [email protected]

Visit booth number 29 and 30 to explore Elsevier’s high-quality journals and important new books. Elsevier’s toxicology journal programme includes prestigious journals such as Toxicology, Toxicology and Applied Pharmacology, Toxicology Let-ters, Toxicology in Vitro, Food and Chemical Toxicology, plus many more. Our toxicology publications include the recently published Comprehensive Toxicology, edited by Charlene McQueen, Handbook of Pesticide Toxicology, edited by Robert Krieger, Fundamentals of Toxicologic Pathology, edited by Wanda Haschek and Information Resources in Toxicology, edited by P.J. Hakkinen. Stop by and discover where the most cutting-edge research is published.


108

EUROPEAN COMMISSION’S RESEARCH DIRECTORATE-GENERAL

Dr Tuomo KarjalainenEuropean CommissionResearch Directorate-GeneralB-1049 BrusselsBelgium

http://ec.europa.eu/research/environment/[email protected]

Over two-hundred multidisciplinary pan-European research projects dealing with environment and health issues have been funded by the European Commission’s Research Directorate-General since the beginning of the Fifth Framework Pro-gramme of Research in 1998. From the first three calls of the currently running Seventh Framework Programme (2006-2013) over 70 projects have already been selected for funding. The aim of the Commission’s participation in the IUTOX event is to provide an information platform for showcasing what kind of research has been funded (including a large number of projects on toxicology) and what kinds of opportunities exist for participation in EU-funded research activities.

EUROPEAN FOOD SAFETY AUTHORITY (EFSA)

Largo N. Palli, 5/a 43121 Parma (Italy) www.efsa.europa.eu http://www.efsa.europa.eu/en/contact/askefsa.htm

The European Food Safety Authority (EFSA) is the keystone of European Union (EU) risk assessment regarding food and feed safety. In close collaboration with national authorities and in open consultation with its stakeholders, EFSA provides independent scientific advice and clear communication on existing and emerging risks. One of the areas in which EFSA advises risk managers at the EU and national level is contaminants in the food chain and undesirable substances such as natural toxicants, mycotoxins and residues of unauthorised substances.

EVOTEC

Two delegates: Dr Adrian Hill and Dr Heike Diekmann 114 Milton Park, Abingdon, Oxfordshire, OX14 4SA, UK www.evotec.com [email protected] [email protected] - [email protected]

Evotec is a leader in the discovery and development of novel small molecule drugs with operational sites in Europe and Asia. The Company has built substantial drug discovery expertise and an industrialised platform that can drive new innovative small molecule compounds into the clinic. In addition, Evotec has built a deep internal knowledge base in the treatment of diseases related to neuroscience, pain, oncology and inflammation. Leveraging these skills and expertise the Company intends to develop best-in-class differentiated therapeutics and deliver superior science-driven discovery alliances with pharmaceutical and biotechnology companies. Evotec has long-term discovery alliances with partners including Boehringer Ingelheim, CHDI, Novartis, Ono Pharmaceutical and Roche.

BARCELONAIUTOX 2010


109

EXPUB, A DIVISION OF EBSCO PUBLISHING

Contact address 10 Estes Street, Ipswich, MA 01938Website www.expub.come-mail [email protected]

Expert Publishing (ExPub) is the premier provider of up-to-date, decision-support chemical information for the global envi-ronmental health & safety community. ExPub databases provide access to millions of documents containing comprehensive human and/or environmental hazard data needed to manage the impact of chemicals in the workplace or on the environ-ment. ExPub provides more than 120 databases containing millions of documents from government and licensed sources covering more than 400,000 unique substances and accessible via 2.25 million chemical names and synonyms. Databases include: ChemEXPERT™, ReproEXPERT™, ListEXPERT™, DrugEXPERT™, and MSDSonline®.

GENTRONIX LTD

CTF BUILDING, GRAFTON STREET, MANCHESTER, M13 9NT, UK WWW.GENTRONIX.CO.UK [email protected]

Gentronix provides preclinical services and solutions that help companies reduce attrition rates and ensure safer products in the pharma, biotech, cosmetics, agrochemical, FFTE, biomaterial and tobacco industry.

Our specialist CRO facility provides out-sourced services for a wide range ADME and predicitive toxicity endpoints.

A particular focus is on providing better hazard identification assays for genotoxicity through the use of our patented human cell GADD45a reporter assays (GreenScreen® HC and Bluescreen HC) and additional in vitro genotoxicity assays.

Currently over 85 companies in 15 countries are using our assays as part of their preclinical testing strategy.

HARLAN LABORATORIES LTD

Zelgliweg 1 4452 Itingen, Switzerland [email protected] www.harlan.com

Harlan Laboratories is a leading global provider of essential non-clinical contract research, research models, animal diets, and services to the pharmaceutical, biotech, medical device, agrochemical and chemical industries, as well as to academic and government research organizations. Our focus is on providing customers with products and services to optimize the discovery and safety of new medicines and compounds. Our mission is helping you do research better.


110

HUNTINGDON LIFE SCIENCES

Huntingdon Life Sciences Woolley Road Alconbury Huntingdon Cambs PE28 [email protected]

Huntingdon Life Sciences, one of the world’s largest non-clinical CROs providing a comprehensive range of services sup-porting the biopharmaceutical, pharmaceutical, industrial chemical and agrochemical industries. With large testing facilities in the UK and the USA, we provide timely, efficient, high quality product development solutions to the changing needs of the market.

We offer fully integrated development programmes or stand alone services such as toxicology, safety pharmacology, drug metabolism, bioanalytical services, biomarkers, regulatory affairs, early clinical support, pharmaceutical stability testing, We are one of the world’s leading CROs in respiratory safety assessment and non-clinical biologics safety testing and infu-sion technologies. www.huntingdon.com

ILSI EUROPE

Avenue E. Mounier 83, B6 B – 1200 Brussels, Belgium www.ilsi.org/Europe [email protected]

The International Life Sciences Institute – European branch (ILSI Europe) is a non-profit, worldwide foundation with the aim to advance the understanding of scientific issues relating to nutrition, food safety, toxicology, risk assessment and the environment by bringing together scientists from academia, government, industry and the general public through the ad-vancement of science.

INSTITUTE FOR IN VITRO SCIENCES

30 West Watkins Mill Road, Suite 100Gaithersburg, MD, USA [email protected]

The Institute for In Vitro Sciences, (IIVS) is a non-profit organization wholly dedicated to the advancement of alternative testing methods. Rigorous scientific and compliance programs coupled with Education and Outreach initiatives have estab-lished IIVS as a global leader in the advancement of alternatives to animal testing. This foundation provides a unique forum in which our customers, contributors, regulatory agencies and animal protection organizations can work collaboratively to advance science and animal welfare.

Assays are conducted under GLP (Good Laboratory Practices) conditions and according to FDA, EPA, OECD, and other guidelines. In vitro assays are performed by the IIVS laboratory in the following research areas: Ocular and Dermal Irrita-tion, Phototoxicity, Dermal Corrosivity, Biological Activity Studies, Acute Systemic Toxicity, and Specialized Investigations. Specialized and/or custom made protocols may be prepared to fit the needs of your study. Please visit us at booth 57 to learn more about activities at IIVS.

BARCELONAIUTOX 2010


111

INSTEM

Diamond Way Stone Staffordshire ST15 0SD - United Kingdom Tel: +44 (0) 1785 825600 Fax: +44 (0) 1785 825625 Email: [email protected] Web: www.instem.com

Instem™ is a leading provider of pre-clinical IT solutions to the Life Sciences. Instem™ offers Provantis™, a fully integrated tox/path software solution. Provantis enables data to be collected, analysed and shared across an organisation of any size, at any stage of a study, from compound receipt through to final report production. From single-users to full-function global toxicology/pathology laboratories, Provantis™ serves organisations of all sizes with on-site or Software as a Service (SaaS) solutions.

Visit booth 17 to see why Provantis is the most flexible, cost-effective and value-added solution on the market.

JAI RESEARCH FOUNDATION

The Global Pre-Clinical CRO, committed to Quality, Safety, Environment & Customer Service.

JRF has endorsement of compliance with the OECD principles of GLP from the GLP monitoring Authority of The Nether-lands. AAALAC accreditation. Our specialization includes:

1. Mammalian Toxicology by various routes • Subacute to Carcinogenicity • Developmental toxicity• Neurotoxicity• Immunotoxicity • In-vivo Toxicokinetics/ADME, in Rodents & Non-rodents.• Endocrine Disruptors under Validation

2. In-vitro & In-vivo Genotox.3. Preliminary & Higher tier Ecotox and E-fate studies4. Full product characterization5. Development and validation of analytical methods for a.i.’s, impurities & metabolites in variety of matrices.6. Regulatory Consultancy.


112

LAB RESEARCH

LAB Research is a leading preclinical service company offering a wide range of drug development services across a global network. Our services include:

General Toxicology • Infusion Toxicology• Inhalation Toxicology • Minipigs • Primates • Safety Pharmacology • Reproduction Toxicology • Juvenile Toxicology • Genetic Toxicology • Ecotoxicology• Physical Chemistry • REACH Services • Bio/Analytical Chemistry • Medical Devices • Wound Healing studies•

We offer a wealth of experience and perform comprehensive services in all areas of non-clinical drug development for the pharma-ceutical, biotechnology, chemical, and agrochemical industries. Please contact us at www.labresearch.com for more information.

LAB Research Denmark Hestehavevej 36A, Ejby 4623 Lille Skensved Denmark [email protected]

LAB Research Hungary H-8200 Veszprem Szabadsagpuszta Hungary [email protected]

LAB Research Canada 445 Armand-Frappier Boulevard, Laval Quebec H7V 4B3 Canada [email protected]

LEADSCOPE INC.

1393 Dublin Rd. Columbus OH 43215 USA www.leadsope.com

Leadscope licenses high quality toxicity databases and QSAR models from the U.S. FDA. The databases and models al-low scientists to predict the potential toxicity and adverse human clinical effects of pharmaceuticals (including impurities), cosmetics, food products and chemicals. The Models, built by the FDA, employ closed training sets prepared using both proprietary and non-proprietary data.

BARCELONAIUTOX 2010


113

LGC STANDARDS, S.L.U.

C/ Salvador Espriu, 59 2º 08005 Barcelona - Spain [email protected] www.lgcstandards.com

Distribuidor y productor de patrones, estándares y materiales de referencia para, entre otros muchos, análisis de drogas en sangre, orina y suero; análisis de fármacos, análisis de contaminantes orgánicos e inorgánicos, de alimentos, de suelos, aguas, vegetales. LGC Standards organiza también ejercicios interlaboratorios.

LHASA LIMITED

www.lhasalimited.org [email protected]

Lhasa Limited is a well established not-for-profit company and educational charity. Our charitable objective is to promote the development and use of computer-aided reasoning and information systems for the advancement of chemistry and the chemistry related sciences.

Lhasa Limited is a leading global supplier of knowledge based software and associated databases for use in metabolism, toxicology, and related sciences.

MERCK CHEMICALS LTD

Contact address Nottingham, NG9 2JR, UK Website www.merck4biosciences.com e-mail [email protected]

Merck supplies over 10,000 life science research products from our well-established brands: Calbiochem®

Tools for signal transduction & life science research Novagen®

Reagents for the isolation, expression, analysis & purification of genes and their protein products, Luminex® xMAP® assaysNovabiochem®

Innovative building blocks, resins and solid supported reagents for peptide synthesisWideScreen®

Precision tools for quantitative analysis including: Beadplex® Luminex® xMAP® assays, enzymatic activity assays, cell based assays, ELISAs


114

MARSHALL BIORESOURCES

Name contact address : BP 2084 69228 LYON CEDEX 02 Website: www.marshallbio.com Email : [email protected]

Marshall BioResources provides purpose-bred beagles, mongrels/hounds and ferrets for biomedical research. Marshall Beagles are recognized worldwide as the leading canine toxicology model. Our dogs are healthy, well socialized and uniform in size. They are bred and raised with genetic consistency in the U.S., Europe (UK and Italy), and China.

MESO-SCALE DISCOVERY

Hary Rakotondrazaka9238 Gaither RdGaithersburg, MD 20877www.mesoscale.com [email protected]

MESO SCALE DISCOVERY® (MSD) develops and markets solutions for singleplex and multiplex biological assays, including assays for toxicology biomarkers, metabolic biomarkers, cytokines, and phosphoproteins. The MSD® platform is based on MULTI-ARRAY® technology, a proprietary combination of patterned arrays and electrochemiluminescence detection, enabling large numbers of measurements with exceptional sensitivity, wide dynamic range, and convenience.

METTLER-TOLEDO

Quantos automated powder dispensing

Quantos combines revolution with tradition. Automatic dispensing of small sample quantities from 1 mg to 1 g based on METTLER TOLEDO’s experience and precise weighing technology. Quantos replaces hours of weighing by hand.

METTLER TOLEDO has long been a leader in innovation – not only in products and services, but in the way we think about everything. Innovation is the art of finding answers before the question is asked.

The integrated solution of Quantos with ToxData offers a whole new benchmark in process safety for preclinical studies. Contact us for more details.

BARCELONAIUTOX 2010


115

MPI Research

54943 North Main Street Mattawan, MI 49071 USA www.mpiresearch.com [email protected]

As a global CRO, MPI Research focuses on providing comprehensive preclinical and early clinical development research to pharmaceutical, biotech, medical device, animal health, and chemical companies. It is the goal of MPI Research to ensure high quality, on-time research that adds value to its Sponsors efforts to discover, develop, and enhance products in a regu-lated environment.

The company is known for its state-of-the-art facilities, excellent study quality, regulatory familiarity, and GLP/cGMP compli-ance and measures its success by the quality of each Sponsor contact. With MPI Research, you’ll get results! For complete information, visit www.mpiresearch.com.

NAL VON MINDEN

Adelina Gómez MonteagudoWebsite: www.nal-vonminden.dee-mail: [email protected]

summary information: Nal von minden is your competent and reliable partner for medical diagnostics and research prod-ucts throughout Europe. We offer to you a comprehensive and innovative product range of the highest quality, as well as outstanding service. Since 2008, nal24 GmbH in Regensburg and von Minden GmbH in Moers, have merged into Nal von minden GmbH. Our company is distributed over three main sites: Regensburg, Moers and Den Haag. 22 years of experi-ence in the development and distribution of medical diagnostic and research products, combined with a highly motivated and experienced team allows us to provide the best quality service.

NOTOX B.V.

P.O. Box 3476 5203 DL‘s-Hertogenbosch The Netherlands [email protected] Contact person: Drs. Harry Emmen, Head of Toxicology

NOTOX specializes in contract research and consultancy for the registration of pharmaceutical products and agro chemi-cals worldwide. More than 300 specialists and 12,300 m2 of modern purpose built laboratories and offices are available for non GLP screening, in vitro studies, regulatory toxicology, analytical support and dossier management including REACH. Our operations have been endorsed by the GLP Monitoring authorities and conform to the principles of OECD/EPA/FDA Good Laboratory Practice and enjoy JMAFF certification.

In addition to the headquarters in ‘s-Hertogenbosch, the Netherlands, NOTOX has support offices in Japan, Switzerland, India and the USA.

NOTOX was founded in 1983 and evolved as a privately held company until 2005. In this year NOTOX became part of a worldwide group of autonomous companies (WIL Research Ltd, OH USA and QS Pharma Ltd, PA USA) providing toxicol-ogy research services. This Trans-Atlantic presence was built with a vision to seamlessly address, the service needs of international industry partners.


116

PANLAB HARVARD APPARATUS S.L.U

C/ Energía, 112 08940-CORNELLA BARCELONA [email protected]

With more than 15 years of expertise in the market, Panlab Harvard Apparatus represents one of the world leading manu-facturers and software developers of products for the behavioural and physiological screening of therapeutic properties of drugs in small laboratory animals.

Panlab Harvard Apparatus best sellers are the SMART video-tracking system for the automated Track Analysis of the ani-mals in a wide range of mazes, the Oxylet system for Metabolism and Intake studies, the Tail-Suspension Test for an easy screening of antidepressive properties in mice and a wide range of solutions for motor, sensorial, and cognitive exploration of animal behaviour.

PDS AG

Dürrenhübel 9; CH-4133 Pratteln mail: [email protected] or [email protected] phone: +41 (0)61 377 8777 fax: +41 (0)61 377 8778

PathData® • ToxData® • ReproData®

Preclinical software tools that help you move your science forward efficiently. Eight of the Top-Ten Pharmaceutical Companies use our products, as do a full range of users from global enterprises, leading CROs, medium & small companies and single users.

In addition to traditional licensing, our software is available through the web on a subscription basis (SaaS) from our GLP-CERTIFIED hosting center. We are budget- friendly- no capital costs and you simply pay-as-you-go.

Contact us today. We’ll listen to your needs and offer solutions for your consideration.

Your Science… Your Vision… Our Software.

BARCELONAIUTOX 2010


117

PERCEPTIVE INSTRUMENTS LTD

Blois Meadow Business Centre Steeple Bumpstead Haverhill - CB9 7BN, UK Tel. +44 (0)1440 730773 Fax. +44 (0)1440 730630 www.perceptive.co.uk [email protected]

Perceptive Instruments develops and markets products for use in genetic toxicology laboratories. These include automatic colony counting systems for the Ames Test and Mouse Lymphoma Assay, and image analysis systems for Unscheduled DNA synthesis and the Comet Assay.

We also have the Ames Study Manager which is comprehensive program for conducting and reporting regulatory Ames tests. Software modules for Historical Controls and Electronic archiving of data now available. All our systems are designed for compliance with Good Laboratory Practice and with the FDA 21 CFR Part 11 Final Rule on Electronic Records and Electronic Signatures.

PHYSIOSTIM

Dr Joffrey DUCROQ [email protected] www.physiostim.com

PhysioStim is a CRO expert in cardiac cellular pharmacology and more precisely in cardiac electrophysiology, GLP compli-ant since 2001.

PhysioStim has acquired a solid and reliable expertise particularly in the field of hERG assays, potassium channels mainly involved in the problems of cardiac repolarization.

PhysioStim offers you GLP studies for your regulatory dossiers and other “follow up” studies, important, essential to have a total vision of the cardiac effects of your compounds.

Safety and toxicology of compounds are evaluated with:

Ionic channel assays (hERG, hNaV1.5, hKVLQT1 … assays), • action potential recordings (Purkinje fibres, atria, papillary muscles…), • isolated cardiomyocytes • isolated Langendorff perfused heart.•


118

PORSOLT & PARTNERS PHARMACOLOGY

9, bis, rue Henri Martin 92100 Boulogne – Billancourt France www.porsolt.com

As a niche CRO, Porsolt & Partners Pharmacology has developed over the last 25 years, a wide range of procedures and models in laboratory animal enabling most of the pharmacological studies for preclinical evaluation of novel substances for their potential therapeutic activity (efficacy pharmacology) and adverse effects (safety pharmacology under GLP). We provide a wide range of in vivo pathophysiological models and in vitro assays across a variety of disease areas including CNS, pain & inflammation, metabolic and respiratory indications, as well as cardiovascular diseases, and gastro-intestinal and renal/urogenital systems

PREVOR

Contact address : Moulin de Verville, 95760 VALMONDOIS, FranceWebsite: www.prevor.come-mail: [email protected]

PREVOR is a laboratory which specialises in the development of emergency treatment of chemical accidents. It is in this ca-pacity that we have been working, since 1958, with the industrial sector in collaboration with the emergency departments.

For more than 40 years, we have investigated chemistry, biology and human physiology to understand the essence of toxicology, man-chemical product interactions and their acute and chronic consequences. Thanks to the work realised in cooperation with academics from Europe and the United-States, we have acquired for more than 40 years a culture of chemical products and their potentials.

Today, based on this knowledge we are able to go beyond the limits of non-optimal solutions in order to increase the safety and the effectiveness of the victim’s treatment and consequently avoid complications.

Now, we are the daily partners of the manufacturers, armies and governments to improve the chemical safety. We are es-tablished in Europe, United-States, Asia and Africa. From day to day, we offer the necessary means to ensure the safety of populations on a professional plan as well as on a civil plan within the scope of governmental programmes for security

ROCHE DIAGNOSTICS GMBH

Roche Applied Sciencewww.Roche-Applied-Science.com

Roche provides state-of-the-art instruments and reagents for research. Discover novel variants in complex genomes with unprecedented sensitivity and specificity using the new GS Junior Benchtop System – sequencing for everyone and ev-eryday – and GS FLX. MagNA Pure 96s purify nucleic acids from 96 samples in <1 hour, LightCycler® 1536s revolutionize real-time qPCR, and NimbleGen arrays find your gene of interest. For cell analysis, RTCA DP Instruments measure cell invasion and migration in up to three 16-well CIM-Plates and Innovatis Instruments automate cell counting using validated processes.

LIGHTCYCLER, GS FLX, GS JUNIOR, MAGNA PURE, XCELLIGENCE and INNOVATIS are trademarks of Roche.

BARCELONAIUTOX 2010


119

RTC - RESEARCH TOXICOLOGY CENTRE

Via Tito Speri, 12/14www. [email protected]

RTC is a contract research organisation specialised in non-clinical safety studies for product registration according to cur-rent international regulatory requirements.

RTC is a leading CRO in Italy with more than 35 years of worldwide experience.

RTC provides experimental and consultancy services to Industrial clients for the development and safety assessment of:

Pharmaceuticals Biotech Products Medical Devices Veterinary Drugs Food Products Chemicals Agrochemicals Biocides

For each class of products, studies are performed according to international guidelines and regulations. Our high standard is guaranteed through approvals by European, American and Japanese authorities.

Our scientific and technological expertise, our skills in communication and project management, combined with our com-mitment to excellence, qualify RTC as the partner of choice in support of our clients’ product development.

SDS DIETEX FRANCE

Contact address: 75 rue du Général Leclerc95210 SAINT GRATIENTel. +33(0)1.30.10.94.90Fax +33(0)[email protected]

SDS Dietex manufacture specialized diets for lab animals. All species, all controls, all packagings, sterilized diets, special diets on customs. Also all sorts of beddings, toys and treats for animals.


120

. SOT (Society of Toxicology USA)

1821 Michael Faraday Drive, Suite 300Reston, VA 20190 USAT:703.438-3115 F:703.438-3113E-Mail: [email protected] site: www.toxicology.org

The Society of Toxicology (SOT) is the largest association of professional toxicologists in the world, with over 6500 mem-bers from more than 50 countries. Each year in March, the SOT holds an Annual Meeting and exposition that is attended by 6,000-7,000 scientists, features presentation of over 2400+ abstracts in a variety of session types, and showcases 400 exhibits of products and services. Members receive discounted registration fees for SOT meetings and the SOT journal, Toxicological Sciences, the premier peer-reviewed, hypothesis-driven publication of original research articles in toxicology. Stop by the booth to meet SOT leaders, get an update on plans for the SOT’s 50th Anniversary Meeting March 6-10, 2011 in Washington, DC, and learn about new programs for scientists from developing countries.

SKINETHIC LABORATORIES

45 Rue Saint Philippe 06000 Nice France www.skinethic.com

Providing you available, predictive user friendly and sustainable in vitro solutions IUTOX 2010, Barcelona SkinEthic Laboratories is a France-based biotechnology company recognized as the world leader in tissue engineering since more than 20 years.

SkinEthic is devoted to develop and produce - under ISO9001 certification - reliable and robust in vitro alternative methods to the animal use in cosmetic, chemical and pharmaceutical industries. SkinEthic models are predictive tools for efficacy and safety screening tests in order to support an integrated decision making during research and development phases. Our two reconstructed human epidermis models, Episkin and RHE, are validated by ECVAM to fully replace the Draize skin irritation test in rabbits and are under integration in the OECD guidelines. Our Human Corneal Epithelium (HCE) model is currently undergoing validation process by ECVAM., for eye irritancy.

Our philosophy is based on 3 main commitments: to support our customers by providing reliable models, to ensure a train-ing and education and, to provide a dedicated service and sustainable in vitro solutions to our partners.

SkinEthic ROBUST – RELIABLE – RELEVANT – READY-to-USE In Vitro Solutions

BARCELONAIUTOX 2010


121

SNBL EUROPE

PO Box 182 Wetherby, West Yorks LS22 7TB United Kingdom E-mail:- [email protected] Websites:- www.snbl.com and www.snblusa.com

SNBL offers toxicology and pharmacology research services in a range of study models with a specialisation in non-human primates including reproduction toxicology, juvenile toxicology, disease modelling and safety pharmacology via telemetry, supported by comprehensive in-house analytical and pathology services, including analytical cytology and immunology.

THE NATIONAL LIBRARY OF MEDICINE

6707 Democracy Blvd. Bethesda www.nlm.nih.gov [email protected]

The National Library of Medicine provides FREE Internet access to its toxicology, chemical, and environmental health infor-mation resources at http://tox.nlm.nih.gov. These resources include the TOXNET® (TOXicology data NETwork) databases; Haz-Map, an occupational diseases database; Tox Town, an interactive guide to commonly encountered toxic chemicals and environmental health risks; and MedlinePlus®, a Web site containing consumer information on poisoning, toxicology, and environmental health.

TRINOVA BIOCHEM GMBH

Kerkrader Str. 10 35394 Gießen/Germany Phone: +49 (0) 641 9 43 90-0 Fax: +49 (0) 641 9 43 90-22 www.trinova.de [email protected]

TRINOVA Biochem GmbH offers reagents for Ames and Ames IITM test. All important reagents for Genetic and in vitro Toxicology in European stock: Lyophilized and frozen metabolic activation products S9 (human, rat, mouse and hamster), Prepared Plated & Bottled Media, Minimal Glucose Agar Plates, Controlchem™ Positive Con-trols, NADPH Regenerating System Reagents, lyophilized Bacterial Strains (required by the OECD Guideline 471). Please visit our booth at the IUTOX 2010 or contact us for more information: [email protected]


122

TUPI MANUFACTURING

[email protected] HISTOLOGYLONGTERM ARCHIVE HISTOPATHOLOGY

• GLP Compliant, timely, security conscious, quality service founded by two of the most experienced toxicological veterinary pathologists in Europe with 35 years histology laboratory management.

• Occupying an extensive purpose-built laboratory allowing clean and orderly slide production - wet tissue to stained slide• Door to door collection/delivery available for wet tissue packed and securely sealed in TUPI steel containers• Slide evaluation and report production• Continuous in house Quality Assurance on every study• Preparation for Long Term Archiving of tissue/blocks and raw data

TSE-SYSTEMS

www.TSE-Systems.com Contact: Dr. Walter Foerster / Sales Manager Europe

TSE Systems is a leading supplier of sophisticated research instrumentation in the global life science market since 1954. Our focus is on providing the total customer solution including expandable, integrated hardware and software platforms for in-vivo studies in neuroscience, phenotyping, drug screening and toxicology. We also offer complete automated systems for inhalation toxicology.

An interdisciplinary team of scientists and engineers provide regular innovations, optimizing TSE products as well as develop new approaches. NEW IN DEVELOPMENT: See our TSE Cell Culture Exposure System for simultaneous exposure of cell cultures to either aerosols or vapors in up to 4 separate exposure units

VITROCELL SYSTEMS GmbH

Contact: Mr. Tobias KrebsVITROCELL Systems GmbHFabrik Sonntag 3, 79183 Waldkirch / GermanyTel.: +49 (0) 7681-24 100Fax: +49 (0) 7681-43 54Mobile: +49 (0) 172-60 40 [email protected]://www.vitrocell.com

VITROCELL© is specialised in the development, manufacturing, sales and service of innovative cultivation and exposure systems for in vitro studies using cells or bacteria. VITROCELL© modules are specially designed for the analysis of gases, environmental atmospheres, nano particles and complex mixtures (e.g. cigarette smoke and diesel exhaust) at the air/liquid interface. The product program includes gas mixing devices, aerosol generators, dilution systems and equipment for dose control. All can be integrated in turnkey cultivation and exposure systems.

The customers of VITROCELL© are leading medical and environmental research institutes as well as pharmaceutical and other industries.

BARCELONAIUTOX 2010


123

VIVOTECNIA

Parque Tecnológico de Madrid 28760 Tres Cantos Madrid – España e-mail: [email protected]

Vivotecnia is a preclinical CRO specialized in Toxicology and PK for product registration according to international regula-tory requirements. We offer a wide portfolio of studies under GLP standards, from rodents (mouse, rat, guinea pig) to larg-er animals (dog, mini pigs and sheep), through different administration routes: from commonly used (oral, intraperitoneal) to the more elaborated (inhalation or dermal) and up to different repeated dose durations. We have extensive experience performing:

Nose-only and whole-body inhalation studies in rats and mice.• Dermal toxicity studies in rabbits and mini pigs.• Ophthalmic toxicity studies in rabbits.• Pharmacokinetics studies in mice, rats, dogs and mini pigs.• Tumorigenesis for cell therapy.• Behavior models such as Morris Water Maze and Object Recognition.• Non-regulatory carcinogenesis studies (Skin carcinogenesis).•

For further information please visit our website at: www.vivotecnia.com

JOHN WILEY & SONS LTD

Contact address: The Atrium Southern Gate Chichester West Sussex PO19 8SQWebsite: www.wiley.come-mail: [email protected] Atrium, Southern GateChichester, West Sussex PO19 8SQ

Visit booth #68 and discover Wiley’s latest books, major reference works and quality peer-reviewed journals . Pick up free sample issues of Journal of Applied Toxicology (celebrating 30 years), Basic & Clinical Pharmacology & Toxicology, Journal of Biochemical and Molecular Toxicology, the 2009 launched journal, Drug Testing and Analysis, and more… Browse and buy at a 20% discount latest editions of General and Applied Toxicology, A Textbook of Modern Toxicology, as well as Frontiers in Toxicology and Quantitative Modeling in Toxicology.


124

XENOMETRIX AG

Gewerbestrasse 25 4123 Allschwil Switzerland www.xenometrix.ch

Xenometrix offers the Ames MPF assay kits for all strains required by the «OECD Guideline 471: TA98, TA100, TA1535, TA1537, E. coli WP2 uvrA, E. coli WP2 [pKM101]

The Ames MPF Kits kit include media, ampicillin, rat liver S9 (optional) and positive controls (optional). The assays are based on the fluctuation and pre-incubation method cited in the OECD Guideline 471, but use liquid media in microplates and have a colorimetric read-out.

Xenometrix also offers cytotoxicity kits with multiple endpoints for one cellular sample. Such an approach enhances the probability of identifying toxic compounds, uses less test compounds and removes inter-assay variability.For more questions, please visit our booth at the IUTOX 2010

BARCELONAIUTOX 2010


125

GENERAL INFORMATIONTechnical Secretariat at the Venues and On-site registration desk will be opent during congress hours.

Registration fee coversDelegates registrationAttendance to all sessionsCongress documentationAttendance certificateCoffee breakLunchesWelcome reception

Accompanying person registration:Welcome receptionPanoramic tour with lunch on the 21st July

Posters PresentationPosters must be allocated from 08:30 to 09:00 a.m. the same date of your presentation. Posters will be exposed in the Exhibition Area during all day. Please check date and presentation time in the program.

Posters should be hang off before 18:00 h. the same date of your presentation, otherwise will be eliminated.

Social EventsMonday, July 1920.00 Welcome Reception at the exhibition area

Wednesday, July 21Panoramic Tour with lunch for the accompanying people registeredDeparture at 10.00 h. from the Venue (outside the venue will be the couches)

Thursday, July 2220.30 Gala dinner at Fira Palace hotel Address: Rius y TauletNo transfers will be provided

Official LanguageThe oficial language of the Congress is English. NO simultaneous translation will be provided.

Badges and SecurityIt is Essentials that you wear your personal badge at all times while in the Congress venue and during the Social Events, as it is the oficial Entrance pass to scientific sessions and other congress activities. For the Social Events, it will also be neces-sary to present the corresponing ticket.

Medical Assistance and InsuranceParticipants are advised to make their own arrangements regarding travel insurance and medical asístanse during the con-gress. Neither the Organization nor the Congress Secretariat are able to accept any responsibility whatsoever for damage or injury to persons or their belongings during the Congress.


126

NO

TE

S

XII International Congress of ToxicologyBarcelona-Spain 19-23 July 2010

BARCELONAIUTOX 2010

TECHNICAL SECRETARIAT: GRUPO PACÍFICOC/ Marià Cubí, 4 1º 08006 Barcelona

T. 93 238 87 77 - F. 932 387 488e-mail: [email protected]

www.iutox2010.org

iutox 2010 barcelona xii international congress of …tox.umh.es › iutox2010 › iutox2010_page...

Documents