I. The Historical Development of Microbiology

A. The Discovery and Significance of Microorganisms

B. Vaccines and Antimicrobial Therapy

C. Microbes and Industry

D. Emergent Diseases and the Post-Antibiotic Era

I. A. Discovery and Significance

• Discovery of microorganisms– 1670s van Leeuwenhoek

I. A. Discovery and Significance

• Spontaneous Generation vs Biogenesis – 1688 Redi – 1750 Needham vs Spallanzani – 1860s - 70s Pasteur & Tyndall

I. A. Discovery and Significance

• Microbes and Disease – 1790 Jenner – 1835 Bassi – 1847 Semmelweis – 1849 Snow – 1867 Lister – 1860s - 80s Pasteur – 1870s - 80s Koch

I. A. Discovery and Significance

• Pure Culture Technique – 1870s - 80s Koch– Streak Plate Method

I. A. Discovery and Significance

• Microbes and the Environment – late 1800s Winogradsky

Beijerinck

I. B. Vaccines and Antimicrobial Therapy

• Vaccines– 1790s Jenner– 1860s-70s Pasteur– 20th century accomplishments

I. B. Vaccines and Antimicrobial Therapy

• Antimicrobial Therapy– Pre-antibiotic era– Antibiotics

I. C. Microbes and Industry

• Water and Wastewater Treatment

• Food Microbiology

• Recombinant DNA Technology

I. D. Emergent Diseases and the Post-Antibiotic Era

• “New” Diseases

• Resurgence of “old” diseases

• Microbial resistance to drugs

• Immunosupression

• Are we in a “post-antibiotic” era?