Issues in Inorganic Synthesis

Ligand synthesis

in NaOH pH ~11

MeOH

20 h or so

Solvent : ethylene glycol

Porphyrin substituents on heme in hemoglobin

Metallation of porphyrin

How do you know when the reaction is done?

Anything change at Fe?

Molybdenum Reactions. List them and conditions

MoOCl2detc2

Mo2O3detc4

MoOS2detc2

MoOdetc2

Fe and Ru Reactions. List them and conditions

FeCl(porphyrin)

Ru(bpy)2(L-pterin)

Mechanism:

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What’s the difference between pictures A and B?

A Bfrom X-ray crystallography from Chem 3D; “guessed” structure

X-ray Crystallography: the closest we can get to photographing our molecules!

• single crystal (not a powder or many tiny crystals)• periodic array of atoms symmetrically oriented• produces accurate (almost) bond distances and bond angles

• The method:• see U.Penn X-ray Facility• see on-line X-ray Course• see illustration of Space Group Symmetry• one of my old structures (on Cu)

A single crystal structure of a Mo molecule from my lab:

Who wants to go see it done?