Essas on Clasical Quantum Dynamics. AFestschrift for Albert W. Saenz. James A. Ellison andHerbert Uberall, Eds. Gordon and Breach, Philadel-phia, 1991. xiv, 246 pp., illus. $60. From a symposium,Washington, DC, Oct 1988.

Essential Molecular Biology. Vol. 2, A PracticalApproach. T. A. Brown, Ed. IRL (Oxfbrd UniversityPress), New York, 1991. xx, 296 pp., illus. Spiralbound, $65; paper, $45. Practical Approach Series.

Exciatory Amino Acids and Synaptic Trans-mission. H. V. Wheal and A. M. Thomson, Eds.Academic Press, San Diego, CA, 1991. xxii, 482 pp.,illus. $129.

Expertis and Decision Support. George Wrightand Fergus Bolger, Eds. Plenum, New York, 1992. xiv,273 pp., illus. $49.50.

Frez Fracture image of Cells and Tissues.Richard L Roberts, Richard G. Kessel, and Hai-NanTung. Oxford University Press, New York, 1991. viii,408 pp., illus. $75.

The Frim of the Palace of the Stuccoes, Acan-ceh, Yucatan, Mexico. Virginia E. Miller. DumbartonOaks Research Ubrary and Collection, Washington,DC, 1992. viii, 72 pp., illus., + plates. Paper, $18.Studies in Pre-Columbian Art and Archaeology, 31.

Frontal Lobe Seizres and Epilpsios. PatrickChauvel et a/, Eds. Raven, New York, 1992. xviii, 750pp., illus. $95. Advances in Neurology, vol. 57.

Haraid Norlin Johnson, M.D. Virologist and Nat-uralist with the Rockefeller Foundation and the Califor-nia Department of Public Health. Interviews Conductedby Sally Smith Hughes. Regional Oral History Office,Banorft Ubrary, University of Califomia, Berkeley,1991. xii, 391 pp. $70.

Horizons In Endocrinology. Vol. 2. M. Maggi andV. Geene, Eds. Raven, New York, 1991. xx, 360 pp.,illus. $106. Serono Symposia Publications, vol. 76.From a meeting, Siena, Italy, Oct. 1990.

Modern Sequental Analysis (SSA) In Honor ofProfesor Herbrt Robbins. Z. Govindarajulu, Ed.American Sciences Press, Columbus, OH, 1992. Spe-

cial issue of Amerian Journal of Matheatical andManagent Scics.

The Molocular and Cellular Biology of the YeastSacoharomyces. Genome Dynamics, Protein Synthe-sis, and Energefics. James R. Broach, John R. Pringle,and Elizabeth W. Jones, Eds. Cold Spring HarborLaboratory Press, Cold Spring Harbor, NY, 1991. x,826 pp., illus. $97; paper, $55. Cold Spring HarborMonograph Series, 21.

Molecular Autolmmunity. Norman Talal, Ed. Ac-ademic Press, San Diego, CA, 1992. xiv, 463 pp., illus.$50.

The Molecular Fabric of Cells. Published onbehalf of Open University, Heerlen, Netherlands, andThames Polytechnic, London, by Butterworth-Heine-mann, Stoneham, MA, 1992. x, 296 pp., illus. Paper,$29.95. Biotechnology by Open Leaming.

Molecular Hydronamics. Jean Pierre Boon andSidney Yip. Dover, New York, 1992. xiv, 417 pp., illus.Paper, $11.95. Reprint, 1980 ed.

Perceptual and Asociative Leaming. GeoffreyHall. Clarendon (Oxford University Press), New York,1992. xii, 300 pp., illus. $45. Oxford Psychology Series,18.

Phenomenology of Natural Science. Lee Hardyand Lester Embree, Eds. Kluwer, Norwell, MA, 1991.xiv, 301 pp. $94. Contributions to Phenomenology, vol.9.

Platinum and Other Metal Coordination Com-pounds In Cancer Chemotherapy. Stephen B. How-ell, Ed. Plenum, New York, 1991. xii, 545 pp., illus.$125. From a symposium, San Diego, CA, Jan. 1991.

Polymer Synthese. Vol. 1. Stanley R. Sandierand Wolf Karo. 2nd ed. Academic Press, San Diego,CA, 1991. xiv, 604 pp., illus. $89.95. Organic Chemis-try, vol. 29.

Recent Advances In Global Optimization. Chris-topoulos A. Floudas and Panos M. Pardalos, Eds.Princeton University Press, Princeton, NJ, 1992. x, 633pp., illus. $69.50; paper, $39.50. Princeton Series inComputer Science. From a conference, Princeton,

May 1991.Recembinrtion in Semiconductors. Peter T.

Landsberg. Cambridge University Press, New York,1992. xxii, 595 pp., illus. $180.

Reproductive Bilgy of In b . Vol. 4,part B, Fertilization, Development, and Parental Care.K. G. and Rita G. Adlyodi, Eds. Wiley Interscience,New York, 1991. xxiv, 527 pp., illus. $166.

The Savage Within. The Social History of BritishAnthropology, 1885-1945. Henrika Kuklick. Cam-bridge University Press, New York, 1992. x, 325 pp.,illus. $44.95.

Sodium Hunger. The Search for a Salty Taste. JaySchulkin. Cambridge University Press, New York,1992. xii, 192 pp., illus. $54.95.

Soft Soap, Hard Sell. American Hygiene in an Ageof Advertisement. Vincent Vinikas. Iowa State Univer-sity Press, Ames, 1992. xx, 168 pp., illus. $27.95.

Software Science and Engineerng. Selected Pa-pers from the Kyoto Symposia. Ikuo Nakata andMasami Haglya, Eds. World Scientific, River Edge, NJ,1991. x, 245 pp., illus. $48. World Scientific Series inComputer Science, vol. 31.

A Study of Logcs. John P. Cleave. Oxford Uni-versity Press, New York, 1992. xiv, 417 pp., illus. $125.Oxford Logic Guides, 18.

Today There Is No Misery. The Ethnography ofFarming in Norwest Portugal. Jfe1ry W. Bentiey.University of Arizona Press, Tucson, 1992. xvi, 177pp., illus. $29.95. Arizona Studies in Human Ecology.

Topics In Varieti of Group Representatios.

Samuel M. Vovsi. Cambridge University Press, NewYork, 1992. xiv, 200 pp. Paper, $34.95. London Math-ematical Society Lecture Note Series, 163.

Toward Unity Among Erniron mentali*s. BryanG. Norton. Oxford University Press, New York, 1991.xvi, 287 pp. $29.95.

Toedc Politics. Responding to Chemical Disasters.Michael R. Reich. Comell University Press, Ithaca, NY,1991. xiv, 316 pp., illus. $45; paper, $15.95.

Ion Channels in the Cardiovascular SystemFunction and Dysfunction

12-15 September 1992 + Westfields Conference Center, Chantilly, VASponsored by National Heart, Lung and Blood Institute, National Institutes of Health

and American Association for the Advancement of ScienceArthur M. Brown and William A. Catterall, co-chairs

This intensive conference will synthesize the recentexplosion of information on sodium and potassium ion chan-nels in the cardiovascular system. New developments incalcium and chloride channels will also be addressed.

Leading scientists will focus on such issues as subunit func-tion, modulation and control, mutagenesis and amino acidreplacement studies, de- and repolarizing sodium and potas-

sium channels, and channel involvement in disease processes

(e.g., arrhythmias, sudden death).

Participants will discuss the ways in which this information

Sessions include: Clinical and Basic Science Tutorials onIon Channels and Cardiac Disease + Ion Channels andCardiovascular Function + Channel Modulation and Auto-nomic Control * Structure-Function of Ion Channels +Molecular Pharmacology + Drug Discovery

Who should attend:+ Basic scientists involved in deciphering molecular aspects

of cardiovascular channel structure and function

* Academic clinicians concerned with disease processes

resulting from channel dysfunctioncould be used in the development of new pharmaceuticals to + Pharmaceutical scientists involved in the design andtreat ion channel mediated diseases. testing of new channel active drugs

For a complete program and information on registration and poster presentations, contact:AAAS Meetings Office, 1333 H Street, NW, Washington, DC 20005; Phone: 202-326-6461; Fax: 202-289-4021

I Ii I I I

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Circle No. 24 on Readers' Service Card

1992AAAS Philip Hauge

Abelson PrizeThe AAAS Philip Hauge Abelson Prize of $2,500, established by theAAAS Board of Directors in 1985, is awarded annually either to:* a public servant, in recognition of sustained exceptional contri-butions to advancing science, or

* a scientist whose career has been distinguished both for scientificachievement and for other notable services to the scientific com-munity.

AAAS members are invited to submit nominations now for the 1992prize, to be awarded at the 1993 Annual Meeting in Boston, MA. Eachnomination must be seconded by at least two other AAAS members.

Nominations should be typed and should include the following infor-mation: nominee's typed name, institutional affiliation and title, ad-dress, and brief biographical resume (please do not send lengthypublications lists); statement of justification for nomination; and names,identification, and signatures of the three or more AAAS membersponsors.

Nominations should be submitted to Amy Crumpton, AAAS Directoratefor Science and Policy Programs, 1333 H Street, N.W., Washington,DC 20005, for receipt by 1 August 1992.

1993 AAAS Scientific Freedomand Responsibility Award

To Encourage Scientists and Engineers to Reflect Upon theSocial Implications of their Professional Actions

The AAAS Scientific Freedom and Responsibility Award, estab-lished by the AAAS Board of Directors in 1980, is awardedannually to scientists and engineers who have:

* acted to protect the public's health, safety, or welfare; or

* focused public attention on important potential impacts ofscience and technology on society by their responsibleparticipation in public policy debates; or

* established important new precedents in carrying out thesocial responsibilities or in defending the professional free-doms of scientists and engineers.

You are invited to submit nominations now for the 1993 award,to be presented at the 1993 AAAS Annual Meeting in Boston,MA. A recipient of the award is selected by a panel of six judges.The deadline for receipt of entries is 15 July 1992.Requests for nomination forms and more information should besent to: Amy Crumpton, Directorate for Science and PolicyPrograms, AAAS, 1333 H Street, NW, Washington, DC 20005.

U

Scientific WordProcessing Software

Scientific Word is a word process-ing program that produces type-set quality formulas, equations,and documents. The program rec-ognizes mathematical symbolsand automatically italicizes, sizes,spaces, and positions symbols forthe user. There is no need to learnunfamiliar codes to enter math-ematics. The user simply clicksthe mouse on symbols in the on-screen panels and they appear inthe document. The symbols canalso be entered with keyboardshortcuts. The program requires acomputer with Microsoft Win-dows 3.0 or higher and a minimumof two megabytes memory. TCISoftware Research. Circle 90.

U

Magnetic RadiationMeter

This hand-held, battery-poweredmagnetic radiation meter can beused to survey the lab for sourcesof electromagnetic interference(EMI) before setting up sensitive

~1-I_

equipment. It has a magnetic fieldmeasurement range of 0 to 10milligauss. A switch allows theuser to detect either low-fre-quency (60 Hz) or high-frequency(16 to 40 Hz) EMI. Low-fre-quency EMI is typical of the am-bient field produced by powerlines and fluorescent lights, whilehigh-frequency EMI typically ra-diates from video display tubes.World Precision Instruments.Circle 91.

MicrovolumeBiodialyser

The Sialomed Biodialyser offersa fast approach to dialysis of bio-logical samples from 10 to 1500gl. Made of inert Teflon, it isavailable for volumes of 10, 50,100, 200, 500, 1000, and 1500 gl,with precut ultrafiltration mem-brane sizes including 0.1, 0.5, 1,2, 5, 10, 25, 50, 100, and 300 K.There is no overflow or cross-con-tamination of samples, and sam-ple loss is minimal. It can be usedfor sample preparations for high-performance liquid chromatogra-phy, electrophoresis, equilibriumdialysis, immunoblotting, bufferexchange, enzyme assay, remov-al of excess radiolabel, removal ofsalts before derivatization of sug-ars, protein binding assay, remov-al of primer in polymerase chainreactions, and other applications.Sialomed. Circle 92.

U

Antibodies toHuman Integrins

An extensive line of monoclonalantibodies to human integrins isavailable for extracellular matrixresearch. The antibodies are suit-able for use in assays such as en-zyme-linked immunosorbent as-says, immunofluorescence, immu-noblotting, immunoprecipitation,and cell attachment studies. TeliosPharmaceuticals. Circle 93.

U

Ultrafiltration DiskMembranes

UltraSep ultrafiltration diskmembranes, manufactured ofpolysulfone, combine high flowrates, controlled pore structures,efficient retention, and excellentsample recovery. The membranesare designed to purify and con-centrate proteins, enzymes, nu-cleic acids, and antibodies. Theyare low protein binding and non-

cytotoxic and do not denature bi-ological samples. They are avail-able in nominal molecular weightcutoffs of 10,000, 30,000, and100,000 in diameter sizes of 25,44.5, 63.5, 76, 90, and 150 mm.Micron Separations Inc. Circle 94.

U

Cryostopped-FlowedSpectrofluorimeter

The SF-40 Series Stopped-FlowSpectrofluorimeters make use ofthe latest in rapid reaction tech-nology to facilitate the study ofthe kinetics of fast reactions be-tween -100° and +60°C. Thecryostatic capability (which slowsthe rate of reaction), the systemdead time of around 2 ms, the ab-sorbance and fluorescence mea-surement capability, and the abil-ity to mix sequentially more thanone reagent combine to producesystems that allow the study of awide range of reactions. Variableratio mixing, simultaneous moni-toring of two detection channels,anaerobic operation, and conduc-tivity detection are all possible.Hi-Tech Scientific. Circle 95.

U

Endonuclease EliminatesInterfering Nucleic AcidsBenzonase is a genetically engi-neered endonuclease that de-grades all forms of DNA andRNA for rapid isolation and pu-rification of proteins, peptides,carbohydrates, and lipids. Be-cause of its nonspecific, activenature, small amounts (1 to 10mg) of Benzonase are sufficient todegrade the interfering nucleicacids into oligonucleotides in the3- to 5-bp range, greatly simpli-fying protein purification pro-cesses. Benzonase assures a lowerviscosity of the sample matrix;consequently, nucleic acid frag-ments can be easily removed bydialysis. EM Science. Circle 96.

Newly offered instrumentation, apparatus, and laboratory materials of interest toresearchers in all disciplines in academic, industrial, and government organizations arefeatured in this space. Emphasis is given to purpose, chief characteristics, and avafl-ability of products and materials. Endorsement by Science or AAAS is not implied.Additional information may be obtained from the manufacturers or suppliers named bycircling the appropriate number on the Readers' Service Card and placing it in a mail-box. Postage is free.

Cryogenic VialsCryosure cryogenic vials are de-signed for storing cell cultures,biological fluids such as serum orsperm, and aqueous cell solutionsat vapor-phase liquid nitrogentemperatures (-195'C). Free-

standing and round-bottomed0.4-ml capacity sizes have beenadded to the existing line of free-standing 1.0-, 1.5-, and 3.5-mlcapacity vials. The four freestand-ing vials feature an octagonal basethat locks into the CryoSure Pro-cessing Rack for one-handed cap-ping and uncapping. The poly-propylene copolymer material isnearly transparent and providessuperior tensile strength and re-sistance to gamma radiation ster-ilization. Evergreen Scientific.Circle 97.

LiteratureSupercritical Fluid Technology is a12-page brochure featuring puregrade fluids and gas mixtures withmajor attention focused on twosupercritical fluid chromatogra-phy-grade carbon dioxide prod-ucts-research purity and ultra-high purity carbon dioxide. ScottSpecialty Gases Inc. Circle 98.

Products for Cell Science is aproduct guide for researchers us-ing mammalian cells. It includes95 application references relevantto centrifugation, immunology,and cell culture, along with ex-tensive notes on the physicalcharacteristics of the products,tips on their usage, and a list ofproduct literature. PharmaciaLKB Biotechnology. Circle 99.

Synthetic Peptides Made to YourSpecifications is a brochure cover-ing custom services. IAF Bio-Chem International. Circle 100.

SCIENCE * VOL. 256 * 22 MAY 19921 228

PERSONNEL PLACEMENT

LIN CLAS.DDAD .EEI

.- Deadlines: Ads are due by Thursday,10 a.m., 2 weeks prior to the issue date.Science is published each Friday,except the last Friday of the year. Callfor holiday deadlines. Advertisementsmust be submitted in writing.

e How to Submit a Classified Ad:Prepare double-spaced typewrittencopy. Do not include any abbreviations.Science will edit and typeset adsaccording to Science guidelines.Deadline for applications stated in admust be at least 2 weeks after dateof publication. Include billing informa-tion, and desired publication date.Available categories: Positions Open,Meetings, Announcements, Coursesand Training.

-Mail or FAX materials to:Science Classified Advertising1333 H Street, N.W., Room 814Washington, DC 20005Telephone: 202-326-6555FAX: 202-682-0816

-Rates: Ads are $42 per line; $420minimum. One line equals 52characters and spaces; centeredheadings equal 32 characters andspaces. A 3% cash discount is grantedto all prepaid ads. If you would likeScience to give estimated cost,indicate on letter.

.- Ads from Outside the U.S.: Prepay-ment made in U.S. dollars by checksdrawn on U.S. banks is required.

- Credit Cards: Science acceptsMasterCard and VISA. Discount doesnot apply to credit cards.

.- Cancellations: Deadline forcancellation is 10 a.m., Tuesday,10 days prior to issue date.

DISPLAYPERSONNELADVERSEME

For rates and information about fractionaldisplay ads (all ads 1/6 page and larger)and all Marketplace listings, contact:

Science Classified AdvertisingDeborah CummingsTelephone: 202-326-6541

Janis Crowley, RecruitmentAdvertising ManagerTelephone: 212-496-7704FAX: 202-682-0816

POSITIONS OPEN

ANIMAL PHYSIOLOGY-HUMAN ANATOMYAND PHYSIOLOGY: ASSISTANT PROFESSOR,Tenure track, Plymouth State College (PSC). To teachanimal physiology (one semester per year) and shareteaching of large human anatomy and physiology course(two-semester sequence-lecture and lab each semester);serve as undergraduate research advisor in area of animalphysiology. Minimum qualifications: Ph.D. in discipline;prior teac at college level advantageous. Startingsalary: $28,000 to $30,000 or negotiable (hiring contin-gent upon eligibility to work in United States). Send curric-ulum vitae and three letters of recommendation to:Chair, Animal Physiology Search Committee, Dc-partmentof£Natural Science, Plymouth State College,Plymouth, NH 03264. Deadline: 5 June 1992 to begin31 August. PSC is an Affirtnative Action/Equal Employ-ment Opportunity Employer and actively seeks women andminority candidates.

ASSISTANT PROFESSOR OF BIOLOGYThe Biology Department of Raymond Walters Col-

lege, the University of Cincinnati, is seeking applicationsfrom individuals to fill a tenure-track position at the levelofASSISTANT PROFESSOR OF BIOLOGY begin-ning 1 September 1992. Primary teaching duties willinclude courses in general biology, genetics, and micro-biology. The successful candidate must have a Ph.D.degree in a biological science and must demonstratesignificant teaching experience with primary course re-sponsibility for lecture and laboratory preparation at thecollege leve. Please send a detailed resume, induding asummary of teaching experience, courses taught, evi-dence of teaching proficiency (student evaluations), col-lege transcripts and three letters ofprofessional reference,to: Dr. Donald M. Meismer, Chairman, Departmentof Biology, Raymond Walters College, University ofCincinnati, 9555 Painfield Road, Cicnnati, OH45236. All application materials must be received by 1July 1992. The University of Cincinnati is an EqualOpportunity/Affirnative Action Employer. Minorities andwomen are encouraged to apply.

UNIVERSITY OF LOUISIVILLESCHOOL OF MEDICINE

DEPARTMENT OF MICROBIOLOGYAND LIMMUNOLOGY

A tenure-track ASSISTANT PROFESSOR positionin MOLECULAR VIROLOGY is available for fall1992. The University of Louisville is part of the stateuniversity system, and the department is undergoingexpansion at all levels. Candidates should hold a Ph.D.,D.V.M., M.D. or equivalent degree, have at least 2 yearsof postdoctoral experience, and have demonsta ex-pertise and productivity in molecular studies involvinghuman or animal viruses. The successful applicant willreceive good start-up support and a 12-month salary andbe expected to establish an independent research pro-gram m molecular virology. He/she will also be expectedto interact with other virology faculty and demonstrateproficiency in teaching virology to medical, dental andgraduate students. Applicants should send by 15 July1992 their curriculum vitae, a statement of r chinterests, and names of three references to: Dr. GordonD. Ross, Chairman, Department ofMicrobiology andImmunology, University ofLouisville, Louisile, KY40292. Equal Employme Opportunity (MIF) Employer.

FIELD VERTEBRATE ZOOLOGIST: ASSIST-ANT PROFESSOR, tenure track, Plymouth State Col-lege (PSC). To teach lower-level vertebrate zoology,which is laboratory and field-oriented, and general biol-ogy I and II including labs; assist upper-division biologymajors on student research projects; contribute to envi-ronmental biology program; serve on department andcollege committees as appropriate. Minimum qualifica-tions: Ph.D.; college-level teahig experience; researchexperience in field vertebrate zoology familiarity withthe Northern Forest. Starting saly: $28,000 to$30,000 or negotiable (hiring contingent upon eligibility towork in the United States). Send letter of application,resume, and three letters of recommendation to: Rich-ard Fralick, Plymouth State College, Natural Science,Bod Hall, Plymouth, NH 03264. Deadline: 5 JuneI to begin 31 August 1992. PSC is an AffirmativeAction/Equal Employment Opportunity Employer and ac-tively seeks women and minority candidates.

POSITIONS OPEN

The Biology & Microbiology Department at the Uni-versity ofWisconsin Oshkosh is see applicants for anentry-level, tenure-track ASSISTANT PROFESSORposition to begin 8 September 1992. Teaching respon-sibilities will be electron microscopy, introductory biol-ogy and to develop a course in plant anatomy. Applicantwill maintain all the electron microscopy equipment,including modern TEM and SEM, and assist otherfaculty and students with research projects. Candidate isexpected to develop a research program in plant biology,to pursue extramural funding, and to supervise master'stheses. Postdoctoral and teaching cxpenence desirable.The university has a Faculty Development Program forlimited funding for research and to provide matchingfunds for extramural grants. Screening of applicants willbegin 15 June 1992 and will continue until the applica-tion deadline of 6 July 1992. Send letter of application,resume, three current letters of recommendation, andofficial transcripts to: M. A. Rou, Chairman, Depart-ment of Biology & Microbiology, University ofWis-consin 8hk WI 94901. An alphabeticalisting ofall nominees and applicants, without differentiation,may be rekeasedfollowing the closing date. The University ofWtsconsin Oshkosh is an Affirmative Action/Equal Oppor-tunity Employer.

UNIVERSITY OF LOUISVILLESCHOOL OF MEDICINE

DEPARTMENT OF MICROBIOLOGYAND IMMUNOLOGY

A tenure-track ASSISTANT PROFESSOR positionis available. Candidates should hold a Ph.D., D.V.M., orM.D. degree and have at least 6 years of postdoctoralexperience. The successfil applicant will receive start-upsupport, be expected to excel in the teaching of medicaland graduate students, and be able to establish anindependent research program in cellular immunologyand/or developmental/comparative immunology. Expern-ence in cytokincs, macrophages, membrane receptorbiology, flow cytometry, immunology of annclids, anti-gen presentation, and NK cells is particularly desirablc.By 1 July 1992 applicants should send their curriculumvitae, a statement of research interests, and the names ofthree refercnces to: Dr. Gordon D. Ross, Chairman,Department ofMicrobiology and Immunolog Uni-versity of Lxuisville, Louisvlie, ICY 40292. The Uni-versity ofLouisville is an Equal Opportunity Educator andEmployer that specficaly encourages applicationsfrom wom-en and minorties.

PHYSIOLOGY, ASSISTANT PROFESSOR (re-search track) position available for investigations on themolecular and biochemical properties of calmodulin-regulated enzymes including myosin light chain kinasesand nitric oxide synthases. An mtegrative research pro-gram on the biological adaptations of vascular smoothmuscle and endothelial cells ofers collaborative opportu-nities dealing with growth responses, dynamic regulationofcontractile elements and signal transduction pathways.Experience in molecular biology required. Please sendcurriculum vitae with three references listed to: James T.Stull, Ph.D., DepartmentofPhyiology,UniversityofTexas Southwesten Medical Center at Dallas, 5323Harry Hines Boulevard, Dallas, TX 75235-9040,telephone: 214-688-6849, FAX: 214-688-2974. AnAfirmative Action/Equal Opportunity Employer.

The University of North Dakota School of Medicineseeks applicants for a position of ASSISTANT ORASSOCIATE PROFESSOR to join the DEPART-MENT OF PHYSIOLOGY under the direction of itsnew chairman. The successful candidate will be expectedto contribute to the teaching of medical and alliedhealthsciences physiology and to establish an independentlyfunded research program. Demonstration of expenencein these endeavors is critical. Applications should incudecurriculum vitae with statements of teaching experienceand research interests, reprints of three selected publica-tions, and the names of three individuals willing to serveas references. Women, minorities and veterans are encouragedto apply. Applications should be sent to: Dr. Wiilis LSamson, Chairman of Physiology, University ofNorth Dakota School ofMedicine, Grand Forks, ND58202. We are an Equal Opportunity/Affirmative ActionEmployer.

SCIENCE * VOL. 256 * 22 MAY 1992

CONDITIONS: Personnel advertising isaccepted only with the understanding that theadvertisers do not discriminate amongapplicants on the basis of race, sex, religion,age, color, national origin, handicap or sexualpreference. The AAAS encouragesemployers to actively recruit and employunderrepresented minority groups. Sciencereserves the right, at its discretion, to declineto publish advertisements submitted to it.

1229

POSITIONS OPEN

The Universit of Texas Health Science Center atHouston, School of Public H l invites applicationsfor two tenure-track (12-month) positions. We are seek-ing one ASSISTANT PROFESSOR at the Houstoncampus and an ASSISTANT/ASSOCIATE PROFES-SOR for a developing Master of Public Health programsatellite in cooperation with the University ofTexas at ElPaso. Candidates should have a Ph.D. or equivalent inenvironmental sciences, environmental health, or a relat-ed area. Responsibilities will include graduate teachingand advising, comniunity service, and research.

andidat for the Houston position are epected tohave research expertise in radiation health or solid/hard-ous waste andto be abk to teach broadly in environmentalscience.

Candidates for the El Paso position will be consideredon the basis of interest and experise in U.S.-Mexicoborder studies.

Qualified candidates for the position should send theircurriculum vitae and three letters of reference to: Dr.Thomas Connor, School of Public Health, The Uni-versity of Texas Health Science Center at Houston,P.O. Box 20186, Houston, TX 77225 by 15 June1992.The University of Tecas is an Equal Opportunity Em-

ployer. Women and minorities are encouraged to apply.

EMMUNOCYTOGENETICIST. Ph.D. or M.D. atASSISTANT or ASSOCIATE PROFESSOR level towork in the 500-bed Temple University Hospital, whichhas active heart, kidney and bone marrow transplantationprograsS. Expertise in HLA typing required. Expertisem research and research funding are assets. Teachmg ofresidents exected. Apply to: H. Simpkins, M.D.,Ph.D., Professor and Chairpe , Departent ofPathology, TEMPLE UNIVERSITY SCHOOL OFMEDICINE, 3401 North Broad Street, Philadel-phia, PA 19140. Temple Univesity is an Equal Oppor-tunitylAff1rnnative Action Employer and strongly encouragesapplicationsfrom women and minorities.

MOLECULAR BIOLOGIST/NEUROBIOLOGIST

MEHARRY MEDICAL COLLEGEApplications are invited for a tenure-track position as

ASSISTANT OR ASSOCIATE PROFESSOR in theDivision of Biomedical Sciences. Candidates are soughtwith training and reach experince in areas induding:genetics, developmental biology, receptor biology and/orsignal transduction mechanisms. Emphasis in neurobiol-

is desirablc but not required. Successful a plicantsbexpeced to partcipate in graduate anprofes-

sional eacing programs and to develop and maintain anextramurally funded research program. Institutional pro-grams in cell and molecular biology, sickle cell anemia,neurosciences, AIDS and tropical discases provide op-portunities for collaborative research. Applicationsfromminority and women candidates are especially encouraged.Please send curriculum vitae, a summary of researchinterests and three letters of references to:

Dr. Manuel S. ValenzuelaChairman, Search Committee

Division ofBiom l SciencesMeharry Medical College

Nashville, TN 37208Tclephone: 615-327-6253

Meharry Medical Collge is an Affirmative Action/EqualOpportunity Employer.

CELL/MOLECULAR BIOLOGISTThe Maisonneuve-Rosemont Hospital Research Cen-

ter, afiliated with the University of Montreal, invitesappliaions fur two tenure-trackc positions at the ASSIS-TANT/ASSOCIATE PROFESSOR level. Ph.D. re-quired. The successful applicant will be expeced to joinone of our three r groups: bone and kidney phys-iolog, reproduction biology or immunology. The dutiesof the position indude the development of a vigor-ous independent research program employig modemrmethods ofcell and/or molcular biology and involvementin graduate training. Positions available 1 July 1992.Pkase forward curriculum vitae, names/addresses of threerefcrences, and future sarch plans to: Dr. C. Perreauk,Director, Research Center, Mai_Rn montHospial, 5415 de l'Asomptin Boukvard, Montr,Quebec, Canada H1T 2M4.

POSITIONS OPEN

ASSISTANT PROFESSORRESEARCH POSMON (tenure track) open for an

individual with an interest in psychoneuroimmunology.A strong research record in a related basic science area(e.g., immunology, neuroscience) and a collaborativeoutlook are essential. Salary commensurate with experi-ence. Housing available. Send curticulum vitae andnames of three references to: Dr. Dana Bovbjerg, PNILaboratory-Box 457, Memorial Sloan-KeteringCancer Center, 1275 York Avenue, New York, Nt10021. Equal Opportunity/Affirmative Action Employer.

VISiTING RESEARCH ASSISTANTPROFESSOR (MR SPECTROSCOPIST)

An immediate position is available for an MRI SPEC-TROSCOPIST with a strong background in electronicsand coil design. Please address inquiries to: Dr. DanielFiat (M/C 901), Department hysio and Bio-physics, P.O. Box 6998, Chicago, IL 60680, tele-phone: 312-996-7609, FAX: 312-996-1414.The University ofIllinois is an Affinnative Action/Equal

Opportunity Employer.

PHARMACOLOGY-UNIVERSITY OF PENN-SYLVANIA. The D t of Pharmacology is re-cruiting four to six additional faculty to the tenure trackr atthe rank of ASSISTANT or ASSOCIATE PROFES-SOR. Ingrs with interests in the broad areas ofanalytical/molecular phrmacology and cellular/moklcularpharmacology will be appointd Examples of potentialareas of interest include: (1) structure and function ofbiomolecules u analytical techniques (e.g., NMR,EPR, MS, molecular modeling, affinity labeling and mu-tagenesis); (2) enzyme-inhibioor/reeeptor-ligand design;(3) drug or seomnd-messenger metabolism; (4) growthfactor signaling; (5) gene manipulation (e.g., gene trans-fer, embryonic stem cells and transgenics); and (6) ionchannel/brain slice electrophysiology. Applicants shouldhave po sdc h experience and the ability todevelop a strong eamurally funded sarch program.Renovated laboratory space and start-up funds are avail-able. Applicationsfom women and minorities are especiallyencouraged. Inquiries should include curriculum vitae, listof publications, reprints or preprints of selected papers,and a statement of research interests. Resumes and threeletters of recomnnndation should be sent to: Searchcommittee, eofPharmaoky, UofPensylva School ofMedidne, Phlalphia, PA19104-6084. The University ofPennsylvania is an EqualOpportunity/iAmative Action Employer.

ASSISTANT/ASSOCIATEFULL PROFESSOR:ZOOLOGICALMEDICINE-CAGED BIRDS. Lveland salary dependent on qualificaons ofseltd applcD.V.M. or e vt Board cerfication or elbility inAmerican Coe ofZooloical Medicine and/or AmericanBoard of Vetnary P s (Avian S ), andcdinial expexne wi cagd birds reqirdaptitudeorexcpeienceinteing and rearch, and qualitiesfr leadership in field Rqust full position descrptionfrom: ClariceMarn,DeparmcntofMedicne,SchoolfoVeterinaryMedie, UnivsofCalni Davis, CA95616, tehe: 916-7521363. Aplications acedthrmough15 August 1992 oruntla candidate is identiLeThe Univest of Calfonua is an Alrmsa*ive ActiEquaOpportnity Employer.

DEPARTMENT OF PHARMACOLOGY, THEOHIO STATE UNIVERSITY COLLEGE OFMEDICINE. Applications are invited for an ASSOCI-ATE/FULL PR FESSOR tenure-track faculty posi-tion. Expertise in one of the following areas is preferred:molecular toxicology, neuropharmacology or cardiovas-cular pharmacology. Outstanding individuals with activefunded research programs and teaching experience suit-able for a department ofpharmacology are ing sought.The successful candidate is expected to continue toexpand his/her research program and to be involved withthe teaching and training of medical and graduate stu-dents. App cants, M.D. and/or Ph.D., should send cur-riculum vitae, statement of rescarch and teaching inter-ests and experience, and the names of three references by30 June 1992 to: Dr. John J. Enyeart, Chair, SearchCommittee, Department of Phannacology, Tbe OhioState Univrity College of Mediane, 198 GravesHall, 333 West Tenth Avenue, Columbus, OH43210-1239. The Ohio State University is anAfirnnativeAction/Equal Opportunity Employer. Qualeied women, mi-norities, Vietnam-era Veterans, disabled veterans and thedisabled are encouraged to apply.

POSITIONS OPEN

ASSISIANT/ASSOCIATE/FULL PROFESSOR.ZOOLOGICAL MEDICINE-CAPTIVE WIDANIMAL. Level and salary dependent on qualifica-tions of seleted applicant. D.V.M. or equivalent, Boardcertification or eligibility in American oll f Zoological Medicine, and clinical cxpencnc with captivewild animals required. Demonstrated aptitude or cxpen-ence in teaching and research, and qualities for leadershipin field. Request full position description from: ClariceMartin, De et of Medicne, School of Veteri-nary Medicie, Universit of California, Davis, CA95616, telephone: 916-752-1363. Applications ac-cepted through 15 August 1992 or until a candidate isidentified. The University of Calyiornia is an All rmativeAction/Equal Opportunity Employer.

INFECTIOUS DISEASE EPIDEMIOLOGISTEmory University School of Public Hcalth seeks an

ASSOCIATE/FULL PROFESSOR (tenure or tcnuretrack) in infectious disease epidemiology. The position(available immediately) entails development of an exter-nally funded researc program and a major role inteaching masters/doctoral-level students. Interested applicants should submit curriculum vitae, publication listand the names of at least three refres to: Dr. M.Elizabet Hallor, Emory University School ofPub-lic Health, 1599 Clifton Road, NE Atlanta, GA30329. Review begins 1 July 1992. Emory University isanEqual Opportunity, Afimtative Action Employer. Applica-tionsfiom women and mhmorites are particulary encouraged.

HEAD, SCHOOL OF HEALTH SCIENCESPURDUE UNIVERS1TY, WEST LAFAYETE,

INDIAN. The School ofHealth Sciences seeks a headwith the following qualifications:

Academic or equivalent cxperience to merit a facultyrank of professor. * Record of excellnce in research inindustrial hygiene, health physics, or related disciplines inenvironmental health sciences. * Strong commitment toexcellence in professional and graduate educaion. *Dem-onstrated le rhip and/or administrativ experience.

Candidates should submit a letter of introductionwhich includes a statement of research interests, curric-ulum vitae, and the names, addresses, and tcelphonenumbers of three references to: Professor William F.Greenlee, Head of the Search Committ Depart-ment of Ph cology and Toxicology, School ofPharmacy and Pharm l Scinces, Purdue Universi-ty, West Lafayette, IN 47907-1334. The review ofapplications will begin immediately and continue untilthe position is filled. Purdue Univmity is an Equal Oppor-tunity/Alrmnative Action Employer.

TECHNICAL SERVICES MANAGERKemin Industries, Inc., a manufaturer ofmold inhib-

itors, antimicrobial compounds, marigold pigmenters,antioxidants, flavors and surfactants for animal feed,seeks a technical services manager fur its North andSouth America operations. Based in Des Moines, Iowa,the successful candidatc will have a Ph.D. in biochemis-try or related field and possess excellent oral presentationskills. The technical services manager will provide tech-nical product information and consulting tor customers,organize university efficac trials, provide technical train-ing for salespeople and distributors, and supervise twotechnical service laboratory personnel. Aba inanimal agriculture as well as commercial experience ispreferrec[ Frequent ovcrnight travel is typical during thework week. Non-smoking environment. Pre-employ-ment physical with drug screen required. Please submit aresume, as well as other reklvant infuirmation, to: Dr. C.E. Nclson, Kemin Industries, Inc., Box 70, DesMoines, IA 50301. Equal Opportunity Employer.

I FREE PRODUCT INFORMATION SERVICE I| Send a letter stating the specifics about your newIIlaboratory and Science will put you in touch with theI

vendors whose products you will need. Write to: I

Science New Lab Service Department Il 1333 H Street, NW I

Washington, DC 20005 J___________~~~~~~~~~~~~~~~~~~~~~SCIENCE * VOL. 256 * 22 MAY 19921230

INSECT BIOLOGYMerck Research Laboratories is seekingapplicants for three positions in ourBasic Animal Science ResearchDepartment. The successful candidateswill form an insect control researchgroup; areas of interest will be: mecha-nism based drug research, identificationof inhibitors of insect hormones andtranscriptional control mechanisms,involved in neuronal development andembryonic pattern formation.

Associate Director/Senior Research FellowTo direct a group of five researchersfocusing on insect control and insecti-cide development. The focus is to gen-erate inhibitors of insect hormones andtranscriptional control mechanisms.The Insect Group will be part of a teamof 25 researchers in the department ofGenetics and Molecular Biology whoseresearch focuses on mechanism baseddrug research in neurobiology, tran-scriptional control and endocrinology.The successful candidate will havea Ph.D. or equivalent degree, with atleast five years of experience in Insect-Physiology, Molecular Biology and/orInsect Genetics. Active research expe-rience with Drosophila melanogasterand/or Manduca sexta is essential. Atleast two years of experience supervis-ing a research group and a strongrecord of scientific accomplishmentare required. (Ref.# S-38)

Senior Research BiologistTo perform research in Drosophilamolecular genetics and neuronal devel-opment. The qualified individual will bepart of a research team focusing onmechanism based drug developmentfor insect control. The successful candi-date will have a Ph.D. or equivalentdegree in Drosophila Molecular Biologyand Biochemistry. (Ref.# S-39)

Staff BiologistTo perform research in the InsectBiology group on insect control.Research experience with Drosophilais essential and familiarity with insectphysiology desirable. M.S. or equivalentin Biology, Molecular Biology and 2 yearsof experience, or B.S. or equivalent with3 years of experience. (Ref.# S-40)Salary, benefits and growth potentialfor these positions are excellent.The work location is in Rahway, NewJersey, approximately 25 miles fromNew York City.Please address resume and outlineof research interests, with three refer-ences to Dr. L.H.T. Van der Ploeg,Director, Department of Genetics andMolecular Biology. Mail applicationsto: Human Resources Manager, P.O.Box 2000, WBC-155, Rahway, NJ 07065.EEO/AA/VH Employer.

e MERCKResearch Laboratories

Pfizer, a U.S. based multinational pharmaceutical company,is seeking a qualified scientist for its Cancer Drug Discoverygroup at our Central Research facility in Groton, Connecticut.We are looking for an individual with strong credentials in theareas of molecular biology and cancer pharmacology.You will participate in the development of strategies toexploit cancer cell selective molecular targets and createapproaches towards cancer drug discovery as novel targetsare identified. Your qualifications should include a PhDdegree and at least two years of postdoctoral training.Individuals who have applied their expertise in the cloningand characterization of novel genes to the field of tumor cellbiology (oncogenes, tumor suppressor genes, differentiation,etc.) are particularly encouraged to apply.Pfizer offers a stimulating research environment and acompetitive compensation and benefits package, along withrelocation assistance to this southeastern Connecticutshoreline community. Please send a resume and the names ofthree references to: Mr. Kym Goddu, Personnel Associate,Employee Resources Department, Pfizer Inc, CentralResearch Division, Eastern Point Road, Groton, CT 06340.An equal opportunity employer.

Central ResarchBringing science to life.

The Jackson Labora-tory, located on the

coast of Maine, ad-jacent to Acadia

National Park, is aworld-renowned center for mammaliangenetics. We are increasing the scientificstaff and doubling the space for basicresearch.

Sr. Research AssistantMolecular HematologyDr. David E. Harrison has an opening forcandidates with at least a BS and suffi-cient experience to be accomplished inmolecular biology. The Sr. ResearchAssistant will design, carry out and adviseothers in molecular approaches to stemcell hematology. The Sr. Research Assis-tant will take the leading role in projectssuch as the following: producing andquantitatively analyzing descendents ofstem cells containing random retroviralinsertions; defining new antigens fromstem cells by identifying and cloningreceptors and their figands. Positionrequires willingness to learn cell biologytechniques, including monoclonal anti-body production, stem cell transplanta-tion, and analysis.Qualified candidates should send resumeto: Harold Wheeler, Manager of HumanResources, The Jackson Laboratory,600 Main Street, Bar Harbor, ME 04609,(207) 288-3371.an affirmative action/equal opportunity employer

bheJacksonELaboratorgj

Postdoctoral PositionsMolecular Toxicology Group

The Biomedical Sciences Division at the Lawrence LivermoreNational Laboratory has an exciting program to investigate theeffects of chemicals on DNA, mutation and cytogenetic endpoints.This is part of a larger program to investigate the cancer andmutation risk posed by chemicals present in the diet and theenvironment. We are seeking several postdoctoral fellows withrecent Ph.Ds, to work as part of an interdisciplinary team ofbiologists, biochemists, toxicologists, and physicists in the followingareas. Appointments will be initially for two years with the possibilityfor a 1 year extension, depending on funding and project status.

Metabolism (2)POSITION A -Successful candidates will be responsible for con-ducting studies on whole body metabolism, pharmacokinetics, andbiointoxification/detoxification pathways of chemical carcinogens.These positions require a Ph.D. in Biochemistry, Toxicology, Phar-macology or related field with experience preferred in metabolitesynthesis, radio-isotope tracer studies, pharmacokinetics, and/oranimal handling. Some experience with molecular biology or immu-noassays is desirable.

Biophysics (1)POSITION B -We are seeking an individual with a Ph.D. inbiophysics to study the interactions of carcinogens with DNA.Experience in nucleic acid chemistry and quantum chemistry ishighly desired.

DNA and Protein Chemistry (2)POSITION C -These individuals will conduct studies on the interac-tions of chemicals with macromolecules, and study the relation-ships between molecular damage and biological effect. The posi-tions require a Ph.D. in Biochemistry, Toxicology, Pharmacology orrelated field with experience in DNA adduct analysis, electrophore-sis, protein chemistry, mammalian cell culture, animal handlingand/or molecular biology.

Cytogenetics (2)POSITION D -Applicants for these positions should have a Ph.D.degree orthe equivalent in genetics, molecular biology, ora relateddiscipline. The first position requires experience in molecular biol-ogy, including DNA cloning-and isolation, phage and cosmid libraryconstruction, and PCR and nick translation with non-isotopic mark-ers. Candidates with at least some experience in cytogenetics willbe preferred. A second position requires experience in cytogenet-ics, including tissue culture, metaphase chromosome preparationand analysis, and fluorescence in situ hybridization. Candidateswith at leastsome experience in molecular biology will be preferred.Applicants must be able to interact constructively with a largeresearch team and with other research groups. Computer literacyand ability to work with small laboratory animals are also desired.

For further information contact: Drs. James Felton (510)422-5656 or Ken Turteltaub (510) 4234152 (Positions A, B,C) or Dr. James Tucker (510) 423-8154 (Position D).

Interested applicants should send their CV indicating positionpreference to: Phil Harding, Professional Employment, Dept.A92216BS, Lawrence Livermore National Laboratory, P.O. Box5510, L-725, Uvermore, CA 94551. LLNL is an equal opportunityemployer. Minority applicants are encouraged to apply.

Un versityof California

11 Lwrence UvermoreNational Laboratory

ACS Eminent ScholarFACULTY POSITIONCANCER CELL/MOLECULAR BIOLOGYUniversity of FloridaCollege of MedicineApplications and nominations are invited for theAmerican Cancer Society Edward R. KogerEminent Scholar Chair in Basic Cancer Re-search. The successful candidate for this facul-ty position will hold a Ph.D. or M.D. degree, andshe/he will have demonstrated excellence inresearch on the cellular and/or molecular biolo-gy of cancer. This could include cell divisioncycle control, cytokine action, molecular genet-ics, chromosomal/chromatin structure, onco-gene molecular biology, or other basic researchareas holding great promise for fundamentalbreakthroughs in understanding and controllingcancer. Commitments for laboratory and officespace, start-up funding, as well as other re-sources will assure the Koger Scholar's sus-tained trajectory to intemational eminence. She/he can also play a significant role in efforts tobuild a major cancer research center at theUniversity of Florida. Appointment in an appro-priate department within the College of Medi-cine will be based upon the candidate's accom-plishments and field of interest. The closingdate for nomination or application (includingCurriculum Vitae, statement of research goals,current funding, and three letters of reference)is July 31, 1992. Address all correspondence to:Daniel L. Purich, Ph.D., ChairmanKoger Scholar Sarch Advisory CommitteeDepartment of Blochomistry &Molecular Biology

College of Medicine, Health Science ConterGainesville, FL 32610-0245.

(An Equal Opportunity!Affirmative Action Employer)

Cyanamid uses novelapproaches to discoverand develop new therapeuticsin parasitology.

At the Agricultural Research Division ofAmerican Cyanamid Company, you'll be part of awinning team that has produced 17 newproducts in 4 years. We have a long-rangecommitment to discovering ways to increaseworldwide crop and livestock production throughchemical, biochemical and biological research.This commitment is evidenced by our expandingresearch budget which has tripled over the lastdecade.The following opportunities exist in our AnimalDiscovery Department and Clinical DevelopmentLaboratory, where you will find a dedicated effortto treat and prevent disease, promote growthand improve feed efficiency In livestock andpoultry.ParasitologistVProtozoologistThe research scientist we seek will administer aprogram geared toward discovering newanticoccidials/antiprotozoals. We require a PhDwith post-doctoral training in protozoology,molecular parasitology, parasite biochemistry ora related discipline. A background In Immunolo-gy, avian physiology and novel approaches toidentifying new therapeutics is desirable.Dept. RHS

Research ParasitologistThe successful candidate will conduct studies onthe efficacy of anthelmintics in farm animals.Studies require experience with experimentalinfections In farm animals and Interpretation ofresults. A PhD in parasitology and at least 2years' experience in conducting expedmentswith large animals are required. Dept. KSAmerican Cyanamid Company offers an excel-lent compensation and benefits package whichincludes 401 (k) savings plan, flex-time workschedules and a convenient location one hourfrom New York City or Philadelphia. We inviteyou to forward your resume, indicatingappropriate position code to: Employment Office,American Cyanamid Company, AgrculturalResearch Division, RO. Box 400, Prnceton, NJ08543-0400. An Equal Opportunity EmployerM/F/HN.

_! CVAiAMD

PulmonaryResearch1

Genentech, Inc., a leader in the biotech-nology industry, is currently seeking twoscientists to join our active pulmonaryresearch program Youll be involved innew research in the area of obstructivelung disease and in ongoing programssuch as the study of aerosolized DNasefor the treatment ofairway obstructionassociated with cystic fibrosis, chronicbronchitis and pneumonia.

Pulmonary ScientistJoin our team of scientific investigatorsin finding new molecular approaches tothe treatment of lung disease.

We're seeking an individual with a PhDorMD and expertise in pulmonarypathiology and/or anatomy, animalmodels of lung disease, and theirrelation to human diseases, such asemphysema, chronic bronchitis, cysticfibrosis or asthma. A strong interest inmolecular mechanisms of lung injuryand repair is highly desirable.

Pulmonary!Aewesol Pharmacologistor PhysiologistAs a member of a multidisciplinarygroup, you'll be involved in the develop-ment ofnew aerosol treatments of lungdisease. A strong interest in the aerosoldelivery of proteins, peptides and/orgenes is highly desirable.

We require a PhD and expertise in theperformance of inhalation studies inexperimental animals.

Our progressive company offers anexcellent salary and benefits packagewhich includes child care facilities, freehealth club membership and fully paidmedical/dental/vision coverage. Pleasesend your resume to Genentech, Inc.,Human Resources, Dept. WS, 460 PointSan Bruno Blvd., South San Francisco,CA 94080. We actively support andpromote affirmative action and equalopportunity employment Women andminorities are encouraged to apply.

Genentech, Inc.

SCIENTIST(ASSOCIATE)

Assoc. Scientist will en e in variey of molec.blo. analyses for R&D of new biochem. products.Will exercise tech. discretion in design and ex-ecution of coaborative sdint. projects. Will per-form complex biochem. research using numer-ous techniques.Specific responsib. incl.: inves . creation anddevel. of new methodsandecogs for projectadvancement; rendering detaild obsrvations,analyzing data and intep. resuls of rIments

.os tdch. reports, summar-s,andquant. anayse; proct hader on seleterroiecs;train, and/or supervis.pennel;pafidp.ins. conferencesand wor. wrilngs tosdent

Appi. must have working knowl. of plasmid prep.and Isolation; nortern and souten bting; aga-roseand polyacrylamldegel r pis;trans-fecion; sizing gl ch q itaon ofDNA and RNA; protein separon analysis; DNAsequencing; DNA footprlnting and clonin.Ed. and Exp. Req.: M.S. in Bochem., Molec. Bio,or a related field, with two years of relevantacademic or prof. lab exp. In Hlu of an M.S., a B.S.In Biochem., Molec. Blo. or a related field, withfive years of relevant academic or prof. iab exp.,lab exp. In isolation, abeling, sequencing orhybridisation of nucsic acids would be releanSalary: $31,315 per year; Hours 8:30-5:00 M-F.Mail resume and copy of ad to: tnt ofEcronei id EmplnWl Dv.emsnW,1 100North EutwSwt oom #212, Bu _le% MD21201. Job Order No. 91402 JOB LOCA-TION: GAIHERSBURG, MID.

Senior ResearchMicrobiologistThe Medical Research Division ofAmerican Cvanmid has an immediateopening in GoeMupblobg Gm ofthe Fementation Develomnt a-ment. This group I InvolVd in a num-ber ofproJects to Produce commerciallyuseful compou for human and ani-mal use. These pro Include antibi-otic fermentations 1nStreptomyces,cloning and exression ofrecombiantproteins In LcsbU and the devepmentof blocatalydc processes for the produc-tion ofpharmaceutical intermediates.The successful candidate wil performlaboratory work directed towards theisolation ofimproved stains and mediaoptimization for antibiotic productionthrough the understanding ofmetabolicpathways and the regulatuon ofmetabo-lism. FanilWdtv with standard mkrobi-ological/genetk/blochemical tech-niques such as mutagenesis, bacterialgrowth studies and enzyme ass@yinecessary. A PhD. is preferred alongwith 2-3 ears ofp ocood expet-ence; an S der and several years ofrelevant ndusial experience wnl alsobe considered.We are located in Rockland County, 25miles north ofNew York City. For con-sideration, send your resume with

salary requirements to:( _ Professional Employ-

ment Rprsna[e

Reseac Iison,Lederle Laboratories, Pear

River, NY 10965.An Equal Opportunity Employer M/F.

MOS~NS OPEN

INTESINAL CELL BIOLOGISrThe Nemour Rescarch Pro¶mi of the Alfred I.

duPont Instiute intends to establish a GastroentrologyResearch Laboatory and imites applis for theposition ofDIRECIOR OFLABOATORY. We areseeking an individual whose inters ie insome ct ofintetinal cell biology/physilogy h, preablywitheence using cultured intestinal ccli lines. In thisposition the appoitee will pursue his/er own indepcn-dent r rch and also,promote collaborativc researchwith existing progams m intestinal cellular e me-tabolism, transport, and gasintestinal motilit andinflammation. The Nemours Reearh Prgrams current-ly include a variet of actve progms in several areas ofcell and developnl biol.The Alfred I. duPont Institute is a rapidly gowing

multidisciplinary childres hospital and he mijor podi-atric tehing affiliate of Jf s Medical Coll.Growth of the Gastgonterolgy Research P m hasbeen occurring in paraUll with the development of anacademically oriented clinical program in pediatric gs-troenterology and nutrition. The tnterology Divi-sion will be staflid by three fiulltime physician mvesti-ato,rs, along with rescarch technical support, by July

1992.Interested parties should mail a letter of interest,

curriculum vitaw, and salary history (requird) to: AlfredL. duPont Institute, Resarch D m P.O. Bas269, Wilmingtn, DE 19899, ntion: ResearchAdministration. Applications will be accepted until theposition is filled.

PROGRAM DIRECTORNATIONALRESCH INiTATIVmCOMPETITIVE GIRANT PROGRAM,

UNiTED STATESDEPARTMENT OF AGRICULTURE (USDA)The National Research Initiative Competitive Grants

Program (NRICGP), U.S. Department of Agriculture,seeks a qualified scientist to serve as a Program Directorfor grant review and dministon in the area of animaldisease research. Candidates must have a D.V.M., Ph.D.or other degree with major study in microbiology,veerinary pathology, physioloy, parasitology, virolog,veterinary science or a r dspline of bioogicalsCienc. In addition, candidates must have spealizedexpenence.

Closing date is 22 June 1992. For fiuther informationon this full-time, permanent position, contact: Dr. Rse-.mary R. Gra, NRICG1E, Rom 323GBuilding, 901 D Street, SW, Wa in , DC20250 2200; teephone: 202-401-6234. For infor-mation on application procedu ms, contact: Ms.Kathy n, P SgSphone: 202-720-9811. USDA is an Equal O unityEmployer.

THE SCHOOL FOR FIELD STUDIESIN CONJUNCTION WITH

NORTHEASTERN UNIVERSITYRESIDENT FACULTY POSMONSRESOURCE MNAGEMBENT ANDCOASTAL ZONE MANAGEMENT

Resident Faculty for fiul-time teaching positions inBaja, Mexico, and the Caribbean. Teach 30 students persemester in an intdiscplinry case-studies ch.Hands-on field-oriented program.Am: licatS must havereevant field research experience it regpon, excclkntundAduate ching ba and ladeshipskills. Ph.D. p ed, M.S. minimum. To apply Send a

iled letter with curriculum vitae to: M Srch,School fo Fied Stuies, 16 Broadway, Bery, MA01915 or FAX: 508-927-5127.

RSEARCH 1FACULTY POSMON, SCHOOLOF MEDICIN'E, UNIVERSITY OF WASHING-TON. Prostate, cytokine, and/or penile function physi-ologist. The University of Wasintn Depa t ofUrology seeks tO recruit a Ph.D. fellowship-trinedresearcher. Outstanding opportunitytO interact with andSUppOrt ongoing laboratory and dinical rescatCh programs.curricu vitaeto Rhard submit coverMcD.University of Wahigton, De _n f UrooRL-10, Seattle,WA 98195. The University ofWashing-ton is an Equal Opportunity Empoyer.

VICE PRESIDENT FOR SCIENTIFIC AFFAIRSThe Henry M. Jackson Foundation for the Advancement of Military Medicine invites

applications for the position of Vice President for Scientific Affairs. The Foundation is anot-for-profit, private corporation which is affiliated with the Uniformed Services University ofthe Health Sciences (USUHS), a Department of Defense medical university whose primarymission is to provide high-quality, career-dedicated military and public health service physi-cians and scientists.The Foundation assists the Uniformed Services University through a variety of programs

including support for research and management of endowment funds, special researchprograms and other projects. It carries out medical research and education programs undercooperative arrangements with the USUHS and provides the focus for interchange for theUSUHS with private industry for research and development agreements and for technologytransfer programs. In addition the Foundation participates directly with other federal agencies,not-for-profit corporations, universities and private industry to conduct a wide variety ofresearch programs all focused on integrafton of military and civilian medical science for theadvancement of military medicine.

For this position the Foundation is seeking an energetic individual with a broad scientificbackground and thorough knowledge of university level academics, medical scientific re-search, technology transfer, and basic and ciinical sciences. Applicants must have demon-strated success and proven abilities to work with academic institutions and diverse constitu-encies, and to communicate effectively with department chairs and faculty, business andindustry representatives and government officials. The applicant must possess a doctoraldegree in medicine or a related field. Experience and knowledge of inter-institutional cooper-ative programs and an understanding of the role of medicine and medical science within themilitary would be advantageous.The incumbent will serve as the chief scientific officer, Vice President and Deputy Director for

the Foundation and will participate fully in the overall planning, management and operations ofthe Foundation. The selected individual will work with and for the President of the Foundationto foster the goals of the Foundation and will act on behalf of the President in his absence.Review of applications and nominations will begin on June 1, 1992 and will continue until the

position is filled with an anticipated appointment date of August 1, 1992. Applicafions andnominations should be forwarded by letter with a current Curriculum Vitae and a list of threereferences to:

PresidentHenry M. Jackson Foundation

for the Advanceent of MIItIary MedIcine1401 Rockville Pike, Sultb 600

Rockville, Maryland 20852

__

POSITIONS OPEN

POPULATION BIOLOGIST, BIOSTATISTI-CLAN, MAMMALOGIST. The Department of Bio-logical Sciences at Idaho State University has a nonten-ure-track position which will be available for 1 to 3 years.Responsibilities indude team teaching the human repro-duction and demography section of a large, undergrad-uate nonmajors course each semester, a graduate coursein biometry each fall semester, and courses in populationbiology and mammalogy on alternate years. Previousexperencc with museum collections is desirable but notrequired. Opportunities exist to work with M.S., Ph.D.,and Doctor ofArts students. Applicants will be expectedto hold a doctoral degree. This position will remain openuntil filled, but applicants should send a letter of appli-cation, curriculum vitae, and three lettcrs of reference by22 June 1992 to: Chairperson, Sear CommitteeBox 8007, Department of Biological Sciences, IdahoState University, Pocatello, ID 83209. Idaho StateUniversity is an Equal Opportunity/AffirnativeAction Em-ploye

VIROLOGIST AT NORTHWESTERN UNI-VERSITY MEDICAL SCHOOL. A tenure-track uni-versity FACULTY POSMON is available in the De-partment of Pathology, offering the opportunity for acareer combiniing a major commitment to academiclaboratory medicme and scientific research. The success-ful candidate can be either an M.D. or Ph.D. who has anactive research program and experence in the virologylaboratory (incuding retrovirofogy). Faculty rank andsalary will be commensurate with the candidate's level ofqlification and academic development. The positionhas administrative leadership of a BL-3-level virus re-search/diagnostic laboratory. The institution has made amajor commitment to virology, induding but not limitedto AIDS. Northwestern University is an NIH Compre-hensive AIDS Center and has an active multidisciplinarygroup of investigators in the discipline of virology.Interested candidates should submit curriculum vitae by30 June 1992 to: Dr. Dante G. Scarpeli, Chairman,Department of Pathology, Northwestern UniversityMedical School, 303 East Chicago Avenue, Chicago,IL 60611.

Northwestern University is an Affrinative Action/EqualOpportunity Employer. Hiring is contingent upon the eligi-bility to work in the United States.

HUMAN GENETICSAT THE UNIVERSITY OF UTAH

The University of Utah, Department of Human Ge-netics, would like to fill a faculty position at the RE-SEAARCH INSTRUCTOR level. The departmentwould like to recruit a candidate that has a Ph.D. withfour or more postdoctoral years of research in molcculargenetics of the human. Research experience with avariety of techniques, development of STS-based DNAmarkers, construction and manipulation of YACs andgeneration of physical and genetic maps of the humangenome. The candidate should further have extensiveexperience in mapping and doning of genes causinghereditary disease.

Application deadline will be 1 July 1992. Applicationssubmitted after the deadline may be considered if noqualified candidates have applied by the deadline.Send curriculum vitae and references to: Dr. Ray-

mond Gesteland, Human Genetics RecruitmentCommittee, University ofUtah, Building 533, Room2100, Salt Lake City, UT 84112.The University ofUtah is an Equal Opportunity Employer.

FACULTY POSMON (NONTENURE AC-CRUING) DEPARTMENT OF BIOCHEMISTRY.Instructor position is available 1 July 1992 in the De-partment of Biochemistry, University of Texas (UT)Southwestern Medical Center at Dallas. Nontenure ac-cnring. Must have a Ph.D. degree in biochemistry and amaster's of science degree in a biology-related field.Experience in allele-specific oligonudeotide analysis,PCR amplification and bacterial expression of cy-tochrome P450 in E. coli. Additional experience inenzymatic assays for cytochrome P450 and cDNA don-ing of mitochondrial and microsomal proteins. Sendresume and names of three references to: Ronald W.Estabrook, Department of Biochmistry, Universityof Texas Southwestern Medical Center at Dallas,5323 Harry Hines Boulevard, Dallas, TX 75235-9038. UT Southwestern Medical Center is an Equal Op-pdrtunity/Ajirmative Action Employer.

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The Cardiovascular Diseases Research Unit of Upjohn Laboratories, a division of TheUpjohn Company, has an opening for a biochemistwith a strong background in molecularbiology. Upjohn Laboratories has made a long-term commitment toward understandingvarious cardiovascular diseases at the molecular level. Using molecular, cell biological,biochemical and/or biophysical approaches, the successful candidate will develop aresearch project focused on the role of ion channel (K+ channels in particular) incardiovascular diseases such as hypertension, arrhythmia, and myocardial ischemia.

This individual will be involved in research effortsaimedat successfully cloning K+ channelsthat are of therapeutic interest. You will be a member of an interdisciplinary team ofscientists in the areas of pharmacology, electrophysiology, cell biology, biochemistry, andchemistry, all interested in exploiting therapeutic opportunities in this scientificallychallenging field.

A Ph.D. along with a strong theorefical and experimental background in molecular biologyplus 2-3 years post-graduate experience is required. Prior experience in the application ofmolecular biology techniques to the study of ion channels would be considered a significantplus. An understanding of the oocyte expression system, as well as the electrophysiologi-cal techniques used for the assessment of ion channel function would also be highlydesirable.

Upjohn offers a very competitive compensaton and benefits package in additon to astimulating, multi-disciplinary research environment at our modem laboratories, located inKalamazoo, Michigan. Ourregion provides abundant cultural and recreational pursuits andoffers reasonable housing and living costs. For confidential consideration, please forwarda curriculum vitae to: The Upjohn Company, Corporate Recruiting/Speciality Code 117,7000 Portage Street, Kalamazoo, Ml 49001-099. Please refer to specialty code #117 inyour cover letter. An Equal Opportunity Employer M/F

Our Commitment to Scientific Excellence Continues Logo

Research Laboratories

MOLECULAR BIOLOGIST/BIOCHEMISTThe Department of Immunology Research is seeking both Ph.D. andBachelor-level Scientists to join a multidisciplinary group studying recep-tor biology with particular emphasis on the structure/function relation-ships for both ligand binding and signal transduction. The goal of thegroup is to utilize cutting edge science to develop novel therapeuticagents for the treatment of inflammatory and autoimmune disorders.Senior Research Scientist - The positions require a Ph.D. or M.D. orequivalent with at least 2 years of postdoctoral experience and a provenrecord of original research. Relevant experience in protein biochemistryand/or molecular biology as they pertain to structure/function relation-ships is highly desirable, as is a background in signal transduction.Staff/Research Scientist - Applicants should have an M.S./B.S. or equiva-lent with substantial laboratory experience. Preference will be given tocandidates with a strong background in molecular biology with emphasison cloning, mutagenesis, and expression, or in biochemistry with empha-sis on protein purification and characterization.These are excellent opportunities for motivated and creative individualsto continue their scientific growth and development. Publication andinternal and external collaborations are actively encouraged.Merck Research Laboratories is located in Rahway, New Jersey approxi-mately 25 miles from New York City. Our salaries, benefits and growthpotential are excellent. For consideration, please send your resume withthe names of 3 references to Susan F. Marsella, Ad#120, Merck & Co., Inc.,R80-A3, P.O. Box 2000, Rahway, NJ 07065. An EEO/AA/VH Employer.

4 MERCK

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POSITIONS OPEN

UNIVEtSIT DE MONTRtALTERRESTRIAL VERTEBRATE ECOLOGY

The Departement de sciences biologiques of theFaculte des artes et des sciences, invites applications fora tenure-track position in terrestrial vertebrate ecology,preferably mammalian ecology. Functions: the success-ful candidate will be expected to be able to teachcourses in French at the undergraduate and graduatelevels, to supervise graduate students, and to carry outan active research program. Preference will be given tocandidates who would be able to use the facilities of theStation de biologie des Laurentides. Requirements:candidates shoul[ have a Ph.D. in a relevant field andpostdoctoral or equivalent expetience. Salary: based oncurrent contract agreements. Appointment date: theposition begins 1 June 1993. Interested applicantsshould submit curriculum vitae, two copies of fiverepresentative reprints or preprints, and three letters ofreference before 31 August 1992 to: M. RaymondMcNeil, directeur, Nparteent de sciences bi-ologiqucs, Universite de Montreal, C.P. 6128, suc-cursalc A, Montreal (Quibec), H3C 3J7. In accor-dance with Canadian immigration requirements, prioritywill be given to Canadian citizens and permanent residents(0078).

POSTDOCIORAL POSMON-BIOMOLEC-ULAR SIMUIATION. Participate in the developmentand application of sensitivity analysis metho)ds to studyingbiomoleclar structure-function relationships. Experiencein modeling and simulation of chemical and biomolecularsystems, FORTRAN prramming and computationalwork are advantageous, but candidates with differentbackgronds will be considered. Please send r6sumi andthree letters ofrecommendation to: Dr. Chung F. WongCDepartment of Physiolog and Biophysics, Box 1218The Mount Sinai School of Medicine, One Gustave L.Levy Place, New York, NY 10029--6574. AfrmativeActionqual Opportnity Employer.

POSITIONS OPEN

POSTDOCTORAL POSMON available immedi-ately to study mucosal immunity and host resistance toE. coli urinary tract infection. Studies on antibody pro-duction in the urogenital tract and vaccine developmentwill be pursued. Candidates should have a recent Ph.D.and a strong background in microbiology, immunology,and bacterial antigen purification. Send curriculum vitaenames and addresses of three references, and a descrip-tion of research interests to: Dr. Waler J. Hopkins,Department of Surgery, 600 Highland Avenue, Mad-ison, WI 53792.

POSTDOCTORAL POSMONA postdoctoral position is available immediately with

the USDA Forest Service to participate in an efort todevelop a nuclear gene diagnostic assay for differentiationof strais of the gypsy moth, Lymantria dispar. A back-ground in molecular biology with experience in genedoning and sequencing is desirable. Starting salary at$32,423 per annum plus benefits. U.S. citizenship isrequired. Send curriculum vitae and the names and ad-dresses of three references to: Dr. James Slavicek,USDA Forest Service, 359 Main Road, Delaware,OH 43015. The USDA is an Affirmative Action/EqualOpportunity Employer.

POSTDOCTORAL POSMON in cancer biology.Available immediately to study the role of inflammation(macrophages, natural killer cells, cytokines, reactiveoxygen, nitric oxide, eicosanoids) in mammary tumorprogression and metastasis. Experience with tumor biol-ogy, molecular biology or immunology preferred. Sendcurriculum vitae and names of three references to: Dr.Amy Fuhon, Dep ent of Patholgy, Univenity ofMarylnd SchooI of Medicn, 10 South Pine Street,Baltimore, MD 21201. An Equal Opportunity Employer.

POSTDOCTORAL POSMONS. Available in De-partments of Anatomy, Biochemistry, Molecular andCellular Biology, Microbiology and Immunology, Phar-macology, and Physiology. Applicants must have a Ph.D.or M.D. degree. Positions available during 1992 and1993. Closing date: 31 December 1992 or until posi-tions are filled. Women and minorities are urged to apply.Send applications to appropriate department head: TheUniversity of Azona, Arizona Health Sciences Cen-ter, Tucson, AZ 85724. An Equal Opportunity/Affirma-tive Action/Title IX/Section 504 Employer.

POSTDOCTORAL ASSOCIATEA postdoctoral position is available to study early

development in Xenopus laevis. Possible projects includethe analysis oftranscription and translation factors as wellas developmentally regulated protein localization. Pleasesend resume induding names, addresses, and telephonenumbers of three references to: Dr. Joel D. Richter, c/oPersonnel Office, Worcesatr Foundation for Experi-mental Biology, 222 Maple Avenue, Shrewsbury, MA01545.An AffirmativeAction/Equal Opportunity Employ-er M/F/H.

POSTDOCTORAL POSMONYALE MEDICAL SCHOOL

Position available immediately to study the mechanismand regulation of recombination in mammalian cells,with emphasis on characterization of molecules involvedin immunoglobulin class switch recombination [GenesDev. 5, 2353 (1991); Proc. Nat. Acad. Sci. U.SA. 89,4154 (1992)]. Please send curriculum vitae and names ofthree references to: Dr. Nancy Maizels, De t ofMolecular Biophysics and Biochemisty, Yale Univer-sity School o Medicine, 333 Cedar Street, NewHaven, CT 06510.

POSTDOCrORAL POSMON. NIH-funded train-ing grant, restrited to U.S. citizenu orpermanent residents, forM.D.'s and Ph.D.'s totrain in molclar virology. Traineescan work with faculty in the Medical School, DentalSchool, or Veteinary School at the University ofPennsyl-vania, or at the Wistar Institute. Emphasis is on herpesviruses and human retroviruses. Send curriculum vitae andreferences to: Harvey Friedman, M.D., Infectous Dis-ease Division, 536 Johnson Pavilion, University ofPenn vania, Philadelphia, PA 19104-6073. EqualOpportunity/Affirmative Action Employer.

POSITIONS OPEN

POSTDOCTORAL POSMONAvailable immediately for Ph.D. in biochemistry/phar-

macology/molecular biology to work in a collaborativeresearch program in the general field of hemecytochromeP450 biology. Send curriculum vitae to: Professor A.Kappas, Rocelier University, 1230 York Avenue,New York, NY 10021, or Professor N. G. Abraham,Department ofMedicne, New York Medical Coliege,Valhalla, NY 10595.

POSTDOCORAL POSMONMOUSE DEVELOPMENT

Postdoctoral position available July 1992 to study func-tion and regulation of homeobox genes in mouse cranio-facial and neural development. Expericnce in productionof transgenic mice desirable. Send rdsume and names ofthree references to: Dr. Robert MaXSOn, Keneth RNorris Cancer Hospital and Research Institute, Uni-versity of Soudern California School of Medice,1441 Easdake Avenu, Los Angdes, CA 90033.

POSTDOCTORAL POSMON available in Neu-roendocrinology.

Applications are invited from persons with a Ph.D.and/or M.D. for research with a neuroendocrine groupinvestigating the roles played by neuropeptides in centraldisorders and in small-cell carcmoma. Position rstric toU.S. citizen or resident. Send curriculum vitae and threeletters of reference to: Dr. Willism G. North, Depart-ment ofPhysiology, Dartmouth Medical School, Bor-well Building, Lebnon, NH 03756. Dartmouth Collegeis an Equal Opportunity Employer.

POSTDOCTORAL POSMON to study centralneural control of the respiratory and cardiovascular sys-

tems. Applicant should have experience in extracellular orintracellular recording. Please send application letter,curriculum vitae and names of three references to: AnnC. Bonham, Ph.D., Der t of Internal Medicne,Division of Cardiovacular Medicine, University ofCalifornia, Davis, Davis, CA 95616.

POSTDOCTORAL TRAINING IN NEURALPROCESSES IN COGNMON. The National Sci-ence Foundation has newly established an interdiscipli-nary program investigating the neurobiology of cogni-tion utiuizinF neuroanatomical, neurophysiological, andcomputer simulation procedures. Individuals performoriginal research investigating cortical function at multi-pe levels of analysis. State-of-the-art facilities indude:computerized microscopy, human and animal electro-physiological instrumentation, behavioral assessmentlaboratories, brain imaging, the Pittsburgh Supercom-puting Center, and access to human clinical populations.This is a joint program between the University ofPittsburgh, its Schoolof Medicine, and Carnegie MelionUniversiry. Applications are encouraged from individualswith interest in biology, psychology, engineering, phys-ics, mathematics, or computer science. Applicants mustbe permanent U.S. residents. Application deadline is 20June 1992. For information contact: W. Schneider,Program Director, Ncural Processes in Cognition,University ofPittsbugh, 3939 O'Hara Street, Pitts-bur* PA 15260 n 412.624-7061. E-mail:NUROCOGC@P .B1TNET

POSTDOCTORAL POSMON available immedi-ately to study the role of cytokines in Epstein-Barrvirus-associated lymphoproliferations in organ trans-plant recipients. Knowledge of immunology and tech-niques in molecular biology is desired. Send curriculumvitae, statement of research interests and names ofthree references to: Michael A. Nalesnik, M.D., Divi-sion of Transplantation Pathology, Room E1515Biomedical Science Tower, University ofPittsburhSchool of Medicine, Pittsburgh, PA 15213. TheUniversity ofPittsburgh is an Equal Opportunity/Affirma-tive Action Employer.

SCIENCE * VOL. 256 * 22 MAY 1992

SCIENCEcan publish YOUR LOGO with your one-col-umn line classified ad. No extra fee is assse:you will bc billcd at our regular line rate for thenumber of lines the logo occupies. For details,call Clasified Adverdsing: 202-326-6555.I I

1236

Molecular BiologistRegulation of Gone Expression

The PARKE-DAVIS Pharmaceutical Research Division of Warner-LambertCompany has fostered an innovative and exciting environment for discoveryresearch. A critical component of this effort is the constant push to look for-ward for new therapeutic advances. In this regard, we are committed to ex-ploring the role of gene expression in the pathophysiology of human disease.We seek a research scientist interested in the hormonal regulation of geneexpression to join our new Signal Transduction Department.This scientist will initiate and direct a research effort to study the basic mech-anisms involved in the expression of proteins that are disregulated in dis-eases such as diabetes, inflammation and cancer. The scientist will join ahighly interactive and creative group focused on intracellular signalling forpeptide hormones and growth factors. The successful candidate should bean energetic and productive molecular biologist, with a Ph.D. degree and atleast 3 years of postdoctoral experience as well as a proven record of ac-complishment.Our modern facilities are located adjacent to the University of Michigan cam-pus. Excellent compensation and benefits are only a part of the package. Ourdynamic and challenging research environment offers ample opportunities forpersonal and professional creativity and growth. If you are qualified and wishto be considered, please send a curriculum vitae and list of references in con-fidence to Human Resources Department, Box JDM- 91024, PARKE-DAVIS Research Division, Warner-Lambert Company, 2800 PlymouthRoad, Ann Arbor, Ml 48105. "Smoke-Free Work Environment""Equal Opportunity in Action"

_PARKE-DAVISr

A DIVISION OF5IA

Abbott Laboratories' leadership in the development of newphaBrmaceutical products has resulted in 20conive ye cfrowth. Now, fueled by last year's 18% in e in R& spend-

ing, you couldjoin us and support our vitalrech effors.BIOCHEMIST/IPHARMACOLOGIST

lImmunosciences ResearchWorking within the Immunosciences area of our New DrugDiscovery Group, the candidate we select will contribute toresearch involving inflammatory mediators. A PhD isrequired, as is experience in HPLC, lipid biochemistry,immunoassays and leukocyte cell biology. You must also becapable of supervising assistants and working closely withasociates on a large, susful multi-disciplinary team.Abbott provides an excellent salary and ben6fits packageincluding profit sharing and a stock retirement plan. We arelocated in an attractive suburban setting, approximately 30miles north of Chicago. For confidential consideration,please forward a resume and salary history to: PatriciaHandy, Corporate Placement, Job # 53540, AbbottLaboratories, One Abbott Park Rd, Abbott Park, IL 664Abbott is an Affirmative Action Employer/Smoke-FreeEnvironment.

ABBOlT LABORATORIES

-~tmtQueft

I Il IPostdoctoral

PositionPosition available in the laboratoryof Dr. John Krupinski at the WeisCenter for Research in Danville, PA.The successful applicant will have aPh.D. in biochemistry, cell biology,or pharmacology with experience inmolecular biology. The project willinvolve the expression and character-ization of novel forms of adenylylcyclase. Emphasis will be placed ondetermining those structuralfeatures of the adenylyl cyclasesresponsible for mediating uniquephysiological effects.The Weis Center is a well-equipped,modern research facility in a semi-rural environment. Competitivesalary and fringe benefits areavailable. Please send cirriculumvitae with the names and telephonenumbers of three references to:Human Resources (JK), GeisingerClinic, 100 N. Academy Avenue,Danville, PA 17822-3024.

E.O.E.M/F/H/V

(PROOF)

The sixth

SANDOZ PRIZE FOR

GERONTOLOGICAL

RESEARCH

worth 50,000 Swiss Francs, will be awardedby the International Association ofGerontology at the XVth InternationalCongress of Gerontology, Budapest, 4-9July 1993.Applications and nominations should besubmitted not later than

15 October 1992to John L. C. Dall, MD, Official Coordinatorfor the SANDOZ PRIZE, The VictoriaInfirmary, Glasgow G42 9TY, UnitedKingdom (phone 44 41-649 4545,fax 44 41-649 2206).Information can be obtained from this officeand from any SANDOZ PHARMAcompany.

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At Syva, R & D is serious business.As part of health care leader Syntex,we are a medical diagnostics companymaintaining a strong commitment toscientific achievement and opportu-nity. Consider the following openingsin our new Evergreen/San Jose facility.Senior ScientistIn this critical and highly visibleposition, responsibilities will includedevelopment ofnew automatedassays for seriological diagnosis ofinfectious diseases. This individualwill also lead a small group ofscientists in these efforts.The ideal candidate will have a PhDin Biochemistry, Immunology or

Microbiology, plus post doctoralexperience and 1-3 years experiencein immunoassay development (pre-ferably in infectious dieases).A Master'sdegreed candidate must have 5-7 yearsexperience in immunoassay develop-ment. Suprvisory experience prered.SeniorImmunochemistWe are seeking an innovative andindependent immunologistbiochemistto develop immunoassays formonitoring emerging therapeutictechnologies. This position willcombine all aspects of diagnosticassay development includingidentification of suitable antibodies,protein modification, optimizationof the assay to maximize clinicalutility, formulation, clinical evalua-tion and transfer to production.Background required for this positionincludes a PhD plus 2 years, or equiva-lent experience in Immunology and/orBiochemistry. Strong analytical skillsalso required and knowledge in diag-nostics development, orwnic chemistryand clinical chemitry is preferred.We offer an excellent salary andbenefits package, along with a

wonderful work environment. Pleasesend your resume with salary history,to: Syva, Dept. SWH3, 3403 YerbaBuena Road, P.O. Box 49013, SanJose,CA 95161-9013. Or, you may FAXyour resume to: (408) 239-2516.Principals only, please. Syva is an equalopportunity employer committed tothe values of a diversified workforce.

a Syntexcornpany

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Analytical ChemistsBattelle, Pacific Northwest abomratories (PNL), is an international leader in thepractical application of technology. Battelle PNL is dedicated to finding ways topreserve our environment and keep America technologically competitive.

Our Analytical Chemistry Laboratory is a service oriented laboratory organiza-tion.Wearecommitted to providing ourclientswith high quality, timely analyticalresults.We have immediate openings for two experienced Analytical Chemists.

The ideal candidates will have experience in a service laboratory environment,technical bench chemist experience with some program management experi-ence, and experience with EPA requirements.These positions require a Bachelor's degree in Chemistry; a Master's degreein Chemistry preferred. Candidates must have three or more years of experi-ence in inorganic analytical techniqueswith instrumentation suchas ICP, IC,M(flame, GFM, CVM), and UVNis. Candidates must also have experience inCERCLAWCLP, RCRA SW846, and/or NPDES. Must have excellent computerskills including experience with spreadsheets, word processors, and databases. IBM or compatible experience is preferred. Must have good verbal andwritten communication skills with specific experience in formal report writing.Battelle PNL is located in Richland in Southeastem Washington state. You'llenjoy the advantages of small town living and a wide variety of outdoorrecreational opportunities. Interested candidates should send a resume to:Battelle Recruiting Center, P.O. Box 1406, Dept 6177BAH, Richland, WA99352. Principals Only. EOE.

0 BaP eloe...Putting Technology To Work

Exploring and testing your analytical and intuitive abilities is what a scientific career is allabout. And Burroughs Wellcome Co. can give you those opportunities. We are at the fore-front of important new pharmaceutical developments, with a long record of successes.That means you can have the resources and support to do your best work, and make ameaningful difference. Discover your capabilities at Burroughs Wellcome Co.The Division of Molecular Genetics and Microbiology has need of a scientist to performenzmology, biochemistry and tissue culture studies in collaboration with other scientiststo elucidate the mechanism of action of candidate antiviral agents.Candidates need a Ph.D. degree in biochemistry or microbiology and experience withenzyme mechanism studies, tissue culture techniques, and biochemical analytical tech-niques. Candidates selected for interview will take an on-site writing assessment. Otherfactors to be considered include HPLC and DNA recombinant techniques and experienceextrapolating from the literature.Burroughs Wellcome Co. offers competitive salaries and comprehensive benefits. We alsooffer the advantage of working in North Carolina's celebrated Research Triangle Park, oneof the country's leading areas for scientific research, with the cultural and recreationalopportunities of the Rafeigh/Durham/Research Triangle area nearby. To apply, please sendyour resume, indicating position number in your cover letter, by June 22, 1992, to:karrough Welloae , Rewultin & Staflng Pos.#63833-20, 3030 ComwallisRo, ard Triangle Park NC 27709.

For information on other opportunities with Burroughs Wellcome Co., call our JobInformation Line at (919) 248-347.

BURROUGHS WELLCOME CO.WelioiMe An Equal Opportunity Employer

U.S. Department of Energy DistinguishedPostdoctorAl Research Prram

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ATIIMEFORACHEVEMENTThere is thatplace in time inthe progress ofa company,when it stands at thethreshold ofan era ofsplendid opportunity. ForGlaxo Inc., one of the largestpharmaceuticalfirms in theU.S., that time is now. Wehave worked hard to makethat happen - with high spiritand a strong belief in theabilities and commitmentofour employees.We invite you to experiencethe challenges andaccomplishments afuture withus holdsfor you. Join us todayin thefollowing opening at ourResearch Triangle Park, NCCorporate Headquarters.

The individual willperform project work related toCPDMS Kinetics calculations development and support,chromatography data integration with CPDMS andgraphical data interface.Background must include a BS degree in ComputerScience, Chemistry, or Biology with a minimum of4-6years direct computing experience, or a MS degree or PhDand 24 years experience. Candidates should haveexperience in a Laboratory Automation environmentspecifically with VMS based Chromatography datasystems, preferably VG's Multichrom. Previous experiencewith VAXIVMS and relational database including Formsprogramming required, ORACLE preferred. Ademonstrable working knowledge of either "C" orFORTRAN is a must; bench chemistry and analyticalmethodology experience is a plus.

Join Glaxo and enjoy an excellent salwry,flexible benefits, anon-site recreation andfitness center, a spirit ofenthusiasmand teamwork and outstanding opportunitiesfor careersatisfaction. Equally appealing is our worldfamousscientific, industrial and academic community in ResearchTriangle Park, NC. Send your resume and salary historyto: Hunan Resources Depw*;nen4, Job #3646804-SC,Glaxo Inc., P.O. Box 13398, Research Triangle Park, NC27709. (No Phone Calls orAgency Referrals, Please.) AnEqual Opportunity Employer MIFIHIV.

Glaxo Inc.

National Institutes of Health

RESEARCH SCIENTIST/POSTDOCTORAL FELLOW

(Molecular Biologist)The Laboratory of Cellular Development and Oncology,National Institute of Dental Research, seeks anoutstanding candidate with graduate education and/orexperience in Biochemistry and Molecular Biology for asenior postdoctoral fellowship position. Applicantsshould have at least 2 years postdoctoral training andresearch experience in signal transduction as well asmechanisms of action through non-receptor andreceptor-tyrosine kinases. Additionally, the applicantshould be familiar with nuclear medicine principles andradiation protection, radioreceptor binding assays,enzymology, protein purification, tissue culturetechniques including biological assays for mitogens andtransforming genes, expression of cloned genes inmammalian cells and the use of recombinant retroviralvectors. A substantial record of publications of originalwork in these areas is required. Starting salary will becommensurate with qualifications and experience.Interested candidates should submit a curriculum vitae,several reprints, summary of research interests andnames of three references no later than June 30, 1992.Material should be sent to: Faye M. Harbrant,Personnel Management Specialist, NationalInstitute of Dental Research, NationalInstitutes of Health, Bldg. 31, Room 2C23,9000 Rockville Pike, Bethesda, MD 20892.

NIH is an Equal Opportunity Employer

I

POSITIONS OPEN

CELL-CELL AND CELL-MATRIX INTERAC-TIONS IN LUNG: POSTDOCTORAL POSI-TIONS are available to investigate regulation oflung ccllgrowth and diffcrentiation. Rarch IS focused on recip-rocal epithelial cell-mesenchymal intcractions. Candi-dates should be higly committed to an independentresearch career- ex?erience in methods of cell biologyand/or molculir biology is desirable. Highly qualifiedindividuals may apply by sending curriculum vitae, astatement of career goals, and names of three referencesto: D. Eugene Rannes Ph.D., Department of Cellu-lar and MAolecular Physiolo, Pennsvania StateUniversity College of Medicne, P.O. Box 850, Her-shey, PA 17033. The Pennsylvania State University is anEqual Opportunity/Affirmative Action Employer. Womenand minorities are encouraged to apply.

Applications are invited for POSTDOCTORAL P0-SMONS in the Dep nent of Experimental Patholo-gy. Applicants must ye an M.D. and/or Ph.D. degreeor the equivalent to be considered. Applicants shouldhave documented record of research experience in mo-lecular biology and an interest in cardiovascular biology.Interested applicants should send their curriculum vitaeto:

Michael B. Stem an, M.D.

Department of Experimental PathologyBasic Sciene Building

Ncw York Medical Coll7egeValhalla, NY 10595

Telephone: 914-993-4148FAX: 914-993-4679

POSTDOCTORAL POSMONDEPARTMENT OF MEDICINEHARVARD MEDICAL SCHOOL

A postdoctoral posiion is available for a recent Ph.D.to join a multdisciplinary laboratory studying the con-trol of blood cell difniation, including the molocularbiology and biochemistry of hematopoietic growth fac-tors and their mechanism of action. ExPercnsc withmoleculr biological and/or protein biocheical tech-nique iS tmqlired.cnd rulum vitae, statement of rcsearch interests,

and names of thre refernces to: Arthur J. Sytkows,MLD., bor for Cell and Molculr Biology,New glandDe Hospital, Hard MedclSool, 185 Pilgrim Road, BURL Building, 5thFloor, Bosto, MA 02215.POSTDOCITORAL POSMONS. Integrins and

signal transduction. Positions available immueiately forindividuals with interest in ccli intcractions and a strongbackground in protein phosphorylation or in molecularbiology. Scnd curriculum vitac and names of threerefrcnces to: Dr. R L. Juliano, Department of Phar-mcgy, University ofNorth Carolina-Chapel Hill,ChapelHill, NC 27599-7365. An Equal Opportunity!Ajnrmative Action Emploer.POSTDOCTORAL POSMON available to study

the cellular metabolism and physiological function ofprion proteins. These proteins are components of theunconventional infectious agent responsible for severalnneurodegeneative diseases m humans and animals, in-duding Creutzfeldt-Jakob disease, kuru, and scrapie.Experience in cell biology, biochemistry, or molecularbiology required. Please send curriculum vitac, a state-ment of research interests and cxperience, and the namesand addresses of three references to: Dr. David A.Harris, Department of Cell Biology and Physiology,Washingo Univesity School Medine,South Euclid Avenuc, St. Louis,MO 63110. An EqualOpportunity Employer.POSTDOCTORAL POSMON, BELUGA

WHALE POPULATION GENETICS, available im-medialtely to conduct research into the stock structure ofbeluga whale populations. Cndidates should have ecpe-rience in sequencing mitochondrial DNA, investigatngvariability of nuclear DNA, and analyzing mo[ecularpopulation genetics data. Ph.D. or equivalent required.Send applications, including curriculum vitae, publica-tions list, selected reprints, and names and addresses oftwo professional references, to:

Dr. James W. ClaytonCanada Department of Fisheries and Oceans

501 University CrescentWinnipeg, Manitoba, Canada R3T 2N6

FAX: 204-984-2403

POSITIONS OPEN

POSTDOCRORAL POSMON to study the prionprotein and its association with transmissible encephal-opathies in animals. Experience in protein biochemistryrequired as well as interest in ncurobiology. Please sendcurriculum vitae and names of three references to: Dr. R.F. Marsh, Department of Animal Healti and Bio-medial Sdcmces, Universiy of Wsconsin-Madison,1655 Linden Drive, Madison, WI 53706. The Univer-sity ofWisconsin is an Equal Opportunity/AffirmativeActionEmployer.

POSDOCITORAL ASSOCIATE-MOLECU-LAR CARDIOLOGY. Available immediately, to studymolecular mechanisms of gene expression in cardiactissue and cardiac cells. Please send curriculum vitae andnames of three references to: Mahboubeh Ephbai,Pharm.D., Ph.D., Department of AnesthesoloYale University School of Medicine, 333 CedStreet, New Haven, CT 06510.

Yale Univesity is an Affirmative Action Employer andprovides Equal Opportunities to all applicants.POSTDOCTORAL FELLOW: CARDIOVAS-

CULARPHYSIOLOGY, TULANE UNIVERSITY.Position availabk for Ph.D. or M.D. with experience incardiovascular autonomic physiology to assist in thedevelopment of a research project pertaining to auto-nomic regulation of the electroplhysiologic properties ofthe neonatal heart. Experience with cardiovascular re-search using animal models and physiologic monitoringsystems are essential. Experience in autonomic nervoussystem physiology highly desirablc. Send curriculumvitae and names of three references to: Arthur S. Pick-off; M.D., Director, Pediatric Cardiology Section,Tulane Univerity Medical Center, 1430 T;ane Av-enue, New Orleans, IA 70112.

POSTDOCTORAL FELLOW, NIH STIPENDdepending on years since doctoral degree. Should havetraining in Northern, Southern blots and in situ hybrid-ization. PCR desirable. To be applied to interdisciplinaryproject concering endothelial pathophysiology of cere-bral microirculation and endothelial-smooth muscleinteraction. Both intact vessels and cultured cells will beused. Work may cxpand to indude receptor analysis.Work can begin between 1 July 1992 and 1 July 1993.Funding will last at least 2 years. Forward curriculumvitae and three references to: William RoebmMID., Medical Colege of Virginia-Virginia Com-monwealth Universtt, Box 17, MCV Stion, Rich-mond, VA 23298-0017. FAX: 804-225-3299. Vir-ginia Commonwealth University is an Equal Opportunity!Affirmative Action Employer. Minorities and women areencouraged to apply.

POSMONS OPEN

POSIDOCTORAL ASSOCIATEHarvard-MIT Division of Health Sciences and Tech-

nology seeks an individual to work on the deveopmentof systems for the sustain growth and regeation ofskeletal tissue. This work involves developing methodsand techniques for cell culture of skeletal tissue and fordevelopmcnt of innovative method using polymer mate-rials for use as tissue supports.REQUIREMENTS: Ph.D in biology, chemistry,

chemical engineerng or related field. Must be versed mareas of tissue/organ culture or synthetic biomaterialstechnology.

Interested candidates should send two copies of bothcover letter and risumi refcrencinf Job No. C92-012to: Dr. Cato uenn, c/o MS Personnel Office(E19-239), 77Masas Avue, Cam id MA02139-4307. MIT is an Equal Opportunity/A aive

Action Employer. MIT is a non-smoking envronment.

POSTDOCTORAL FELLOW ORRESEARCH SCIENTIST

Applications are invited for a Ph.D. or equivaln to joina laboratory effrt devoted to theu r of cdl andmnoaler biology ofepidhial cells. Ofparticlarinercst aretheme involvedin the l ofiontanspot in

normal cells and in ccels derived models of hypsion. The successful applicant will be eyxpcted to deveo

research prects within an in iplinary f Sal-

ary and tile commensurate exrnce.

Please send curriculum vitae and a letter describinginterests and accomplis t to: John B. Stokes,M.D., Director, Divsion ofNephroogy,DofIntnlM ii, University of Iowa, Iowa City,IA 52242.

Thte University ofIowa is an Equal Opporunity Employ-er/Ajfirnative Acion Employer. Women and minorities are

encouraged to apply.POSTDOCTORAL RESEARCH ASSOCIATEThe Minonrt Center for Toxicological Research is

acceping applications for a position of postdoctoralresearch assocate.

QOalifications: Ph.D. in to icol y, biochemical phar-macology,or comparable fidd wit training expenence

in neurobehavioral toxicology/pharmacology. The proj-ect is designed to investigate the role of central dopami-

nergic receptors in toxicity of Pb. Sala-ry: $30,000 per year. (Availability contingent upon

uni of a grant.)

Send detailed resumE with letter of interest to:

Dr. Arun L. JadhavAssistant Dean for Reearch & Gradat daon

College of Pharmacy & Health SciencesTexas Soudmhn Univrsity3100 Cleburne StreetHouston, TX 77004

Telephone: 713-527-7557POSTDOCTORAL RESEARCH ASSOCIATE

positions avaiable in active laboratory devoted to studyof cell adhesive receptors and their cxtracellular matrixligands. Areas of special interest include regulation ofadhesive receptor expression during development anddifferentiation, role altered receptr expression in theinvasive and metastatic behavior of tumor cells, anddefinition of receptor recognition sequences present in

matrix molecules. Previous experience in molecular biol-ogy and/or protein and peipide chenistry required.Respond with curriculum vitae and two ktters ofrecom-mendation to: Dr. Samuel A. Santoro, Depaent ofPathology, Box 8118,W Unirsity SchoolofMedicn St. Louis, MO 63710. Equal OpportunitylAfirmative Action Employer.

SCIENCE * VOL. 256 * 22 MAY 1992

POSTDOCrORAL FELLOWMEMBRANE RESEARCH

Position available immediately to study the useof liposomes and lipid-based systems to deliverdefensins for the treatment of op0 rtstic in-fections. This position requir a Ph.D. in phys-ical chemistry, biochemistry, biology, or relateddiscipline with a bacground in liposomology,membrane biophysics or lipid physical chemis-try. Send curriculum vitae and three referencesto: Human Rsou, The Uposome Com-pany, Inc., One Rearch Way, NJ08540. An Equal Opportunity Employer.

on

AITENTION

SCIENCEADVERTISERS$40 SPECIAL

Place your classified ad in any May-August 1992issue of SCIENCE and get double exposure.We'll display the same position announcement atthe Employment Exc1ange during the AAASPacific Division Meeg or Science Innova-tion '92 for only $40 more. Thaes less than thecost of one additional line.When you place your classified ad in SCI-

ENCE, simply let us know that you want to takeadvantage of the $40 Special and we'll do therest. Plcasc specify the meetng ofyour choice orboth meetings.The Emp oyment Exchange will take place at

the AAAS Pacific Divison Meeting, 21-24Junc 1992, at the University of California, SantaBarbara campus; followed by Science Innmova-tion '92, 2I-24 July 1992, at the MosconeConvention Center in San Francisco, California.Thousands of scicntists in various disciplineshave been invited to participate. Act fast and youcan reach this unique pool of candidates.

For more i&nfoma on how you can intrviewcandidates on-sitc please refer to the 8 May 1992issue ofSdence, or Contact Jacquelyn Roberts at(202) 326-6737, FAL (202) 8421065.

1240

LJRECTOR OFMEDICAL RESEARCH

MarhsleldCllnic,a40physiclanmuhitspeclaitynot-tor-prom group practice, Is seeking a M.D. or Ph.D.Director for Its expanding Medical Research Foun-dation. Experience In medical research plus man-agement and excellent communication skills arerequired. The Director Isresponsible forthe planning,development, Implementation and evaluation ofbasicand applied clinical research programs. He orshe reportsdirectlytothe Presidentofthe MarshfieldClinic.

Foundedin 1959,theResearchFoundatbnhasgrownsignificantly and currently includes five completeBasic Science Research Laboratories, the Depart-ment of Epidemiologyand Biostatistics,the NationalFarm Medicine Center, the Rural Heatth ResearchCenter,ongoingclnical research projectsandotherareas of study. This outstanding opportunity is lo-cated In one ot the Midwest's best small cities.

Send curriculum vitae with cover letter to:

William 0. Myers, M.D.WI Chairman

WiJZU Search CommitteeIItTL 1000 North Oak Avenuefirr Marshfield, WI 54449

MARSHF I ELD CLIN IC

POSTDOCTORAL ASSOCIATE POSITIONSTHE UNIVERSITY OF IOWA

Please contact the appropriate department to express your specificinterest:ANATOMY-Dr. Joe Dan Coufter, Professor and Head, BowenSciec Building.ANESTHESIA-John H. Tinker, M.D., Profr and Head.BIOCHEMISTRY-Alan G. Goodridge, Professor and Head, Bo-wen Science Building.DERMATOLOGY-John S. Strauss, M.D., Professor and Head;or Kenzo Sato, M.D., Professor; 2 Boyd Tower, General Hospital.A o ral research associate for the study of electophysiol-ogy of cultured cells.INTERNAL MEDICINE-Openings available in all disciplines inthe Intemal Medicine Departent, College of Medicine, Universtyof Iowa. Contact Francois M. Abboud, M.D. Professor and Head;or Darnis Goerdt, Administrator. Phone 319/356-2850.MICROBIOLOGY-Dr. J. Markovetz, Profe and Acting Head,Bowen Sdence Building.NEUROLOGY-Postdocral ass te st are available inCognitive Neucience, Neurophysiology, Neurobilogy, Cere-brovascular Dise , Epilepsy, Sleep, and Neuromuscular Dis-eases. Antonio R. Damasio, M.D., Professor and Head, 2151 RoyCarver Pavilion.PATHOLOGY-Dr. Richard G. Lynch, Professor and Chairman,144 Medical Laboratories. Research activity in all areas of pathol-ogy.PEDIATRICS-Dr. Frank H. Morriss, M.D., Professor and Head.PHARMACOLOGY-Dr. P. Michael Conn, Chairman and Head,Bowen Science Building. Openings available in all areas of phar-maoology and toxcology.A Ph.D. or equivalent is required. Desirable qualifFicabons arebased on Project Investigators interest for research. Women andmir are encouraged to apply. The UnWeriyofbwa, Collegeof Medkine, Iowa Cfty, Iowa, 52242, is an Equal Oppordunity/Affirmaiv Acton Employer.

Center for Synchrotron Radiation Researchand Instrumentation

is seeking a

STRUCTURAL BIOPHYSICISTA positon in structural biophysics in the Department of Physics atIllinois Institute of Technology will be open in Fall 1992. It isanticipated that the inital appointment will be at the ResearchAssistaAssociate Professor level with conversion to a tenure-track faculty position after two years. We are seeldng an experi-enced Ph.D. macromolecular crystallographer with interest in thedevelpment and use of synchroton facilities for diffraction studies.IIT, through its Center for Synchrotron Radiation Research andInstrumentation, will be responsible for the development ofseveral synchrotron beam lines at the Advanced Photon Sourcecurrently being constructed at Argonne National Laboratory nearChicago. The successful candidate will work closely with theCenter staff on the development of two beam lines for theIndustrial Macromolecular Crystallography Association (IMCA),a consortium of twelve major chemical and pharmaceuticalcompanies. Upon commissioning of the beam lines, it is anfici-pated that this faculty member will become the Director of IMCAoperations at the Advanced Photon Source.Illinois Institute of Technology, founded in 1890, is a prvatetechnological university located in south-central Chicago. TheDepartment of Physics has strong research programs in biophys-ics, condensed matter physics, elementary particle physics andmaterials science, and offers bachelors, masters, and doctoraldegrees.To apply, please send a curriculum vitae and publication list to:

Profesor P. W. Johnson, ChairmanDeparbnent of Physics

Illinois InstItute of TechnologyChIago, IL 60616 USA

Illinois Institute of Technology is an equal employmentaffirrnativeaction employer M/F/H/V.

Pursue Your Biotechnology CareerIn The

Beautiful Ozarks

We challenge motimated scientists in the folbwing ares toexplore these excellent career opportunities:

Post Doctorl Fellw: Poaflon Numbw 101Ph.D. wth 0-3 years d idustW expeience In bihmnistry. This positonwi requwdem d expertise h molecular bology and in one or mored tefolowing areas: prtein purfication, cal cuiture, protein expression,or bacterial fementation.

Blochemis: PoslUon Number 102

MS wih 1-5 years d sao iborafoy ba rgiund hI protehi purfation.woriing knowedgef dr inet DNAtechniques and enzyme assaydeveiopmertihisly desirable.

Mlrobloloolat: PoalUon Number 103

MS with 1-5 years of experience in mobia femmaton. Expertise inbacteral physiology oroel cukure is required. Experience hI optmizationand process devebprrntfocuslng on pron expression isa pius.

Pel-Freez,a ladig and diversiied biotechnology company, Is headquartered inNorthwest Aricansas. The Rogers facliles are 4 mtiea from beautffulBeaver Lake wih over 500 mies of scenic shoreline. We offer a uniqueblend of biotechnology excellence and a high qualityd life. Forcnsideration, send C.V. or resume and sakay hbisyto: HumanResources DepV1BP, Pel-Freez Corporate Offios, P.O. Box 68.Rogers, AR 72757008. P e include positon number. EOE

ammommum-,omtvm

mr-

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LL

-.

OpportuitieMolecular Devices has an active interdisciplinary researchprogram at the interface between biology and silicontechnology. We study the effects of receptor activation on cellphysiology, particularly as revealed by silicon-based biosensorsystems. Molecular Devices develops and manufacturesbiosensor-based instrumentation, software, and reagents.We have the following research opportunities available.

Moleular/Cell BiolgstWith this position we are setting up a molecular biology capabil-ity to complement our biochemical and biophysical researchefforts on signal transduction in eukaryotic cells. An idea of thebroad scope of the research possibilities can be gained fromsome of our recent publications: Science (1989) 246243;P.N.A.S. (1990) 87:4007; Curr. Opin. Struct. Biol. (1991) 1:647;J. Neurosci. (1992) 12:773; J. Immunol. (1992) 138:2040.A PhD and approximately 3 years of pre- or post-doctoralexperience applying recombinant DNA methodology toeukaryotic cells are required. Respond to Dept. MCB.

Product Applications SdcentistResponsibilities will include designing and executing experi-ments on the Cytosensorm Microphysiometer system todemonstrate the utility of this technology within the pharmaceu-tical industry.Experiments will include studies with excitatory amino acids,growth factors, ion channels, brain slices, peptide hormonesand signal transduction probes. Other responsibilities will beanalyzing specific specimens and cell samples from prospectveCytosensor customers; presenting the Cystosensor technologyand products; attending scientific meetings and trade shows;and providing support for customer training, equipment installa-tion and customer follow-up. Up to 30% travel required.A PhD in Pharmacology and/or Physiology and the followingexperience required: 1+ years' post-doctoral in Neurosciences,Neuropharmacology and/or Neuroimmunology; 1 + years'pharmaceutical industry experience in Neuropharmacology.Teaching experience desirable. Evidence of independentresearch and scientific publications mandatory. Respond toDept. PAS.Molecular Devices offers a competitive compensation andbenefits package. Please send your resume, indicatingappropriate Dept. Code, to Molecular Devices Corporation,Attn: Professional Staffing, 4700 Bohannon Drive, Menlo Park,CA 94025. Principals only, please. EOE.

We'll Help

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Simply write us aletter stating the specificsabout your proposed laband the instruments andsupplies you need. Wewill do the rest.

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SCIENCE MagazineNew Lab ServiceDepartment

1333 H Street, N.W.,Rm 830

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f0,

SCIENTIST

Chiron Corporation is a leading East Bay-based bio-technology company developing products to diag-nose, prevent and treat serious human disease. Wecurrently have several exciting positions available.

PRaUEIN FORMULAIIONSCIENTISTYou will design and perform experiments, ulti-mately to develop liquid and lyophilized proteinswhich are stable, pharmaceutically acceptable andclinically compatible. Additionally, you will opti-mize formulation processes such as lyophilizationcycles and filtration for maximum throughput.

Requires a PhD in Biochemistry or equivalent and1-2 years' postdoctoral work. Knowledge of andhands-on experience with protein analytical tech-niques (SDS-PAGE, IEF, HPLC, florescence,DSC, CD) is essential. Familiarity with formula-tion of proteins and lyophilization is desirable.Box# 92-137MH.

MICROBIAL PHYSIOLOGISTResponsibilities include optimizing culture condi-tions for expression of recombinant therapeuticproteins in bacteria and yeast. You will collaboratein the design of microbial host/vector systems anddevelop small-scale screening methods for mediumand culture condition optimization. You will alsocharacterize cell banks and fermentation processesfor regulatory submissions.

Requires a PhD in Microbiology and 5+ years'pharmaceutical biotechnology industry experience.Interest in secretory protein processing and famil-iarity with FDA "POINTS TO CONSIDER FORBIOLOGICALS PRODUCED BY rDNATECHNOLOGY.' Management and teamleadership a plus. Box# 92-138BM.

CLINICAL PHARMACOLOGYSCIENTISTYou will assume responsibility for the daily op-

erations of the clinical pharmacology laboratory.This group is responsible for collecting and ana-

lyzing antigenicity, pharmacological, and immu-nological data from human trials. Additionally,you will integrate these data with the clinicalpatient database while communicating the resultsof these studies to our outside investigators.

Position calls for an experienced MD or PhD whohas demonstrated experience in developing andanalyzing clinical pharmacology and/or immunol-ogy data. Excellent communication and writingskills are necessary. Experience with databasemanagement is a plus. Box# 92-120BZ.

PURIFICAnON PROCES%/DEVELOPMENT SCIENTISTYou will be responsible for the design and devel-opment of purification processes for a variety ofrecombinant proteins. You will also providedetailed biochemical characterization of processparameters as well as intermediate and final prod-uct materials.

Requires a PhD with a solid biochemical back-ground and strong skills in the areas of proteinpurification and protein folding. Knowledge ofcGMP is a plus. Box 92-136BF.

Chiron offers a competitive salary and benefitspackage. For immediate consideration, pleasesend your resume, indicating Box# of interest, to

Chiron Corporation, Human Resources Depart-ment, 4560 Horton Stet, Emeryville,

E CA 94608. We are an Equal Oppor-

tunity Employer.

CHIRONC O R P O R A T I O N

I JJ

D IS C 0 V E R

Houghten Pharmaceuticals,Inc. (formerly Iterex Phar-

maceuticals) located in San Diego.CA is a development-stagebiopharmaceutical companyengaged in drug discoveryresearch/development utilizingour proprietary synthetic peptidecombinational libraries. Thefollowing key positions areavailable due to our rapid growth:

mom DIRECTOR, menMEDICINAL CHEMISTRYWill direct organic synthesis ofpeptide and other lead com-pounds for drug discoveryresearch. PhD in MedicinalChemistry with significant relatedexperience required.

mm DIRECIOR, momBIOANALYTICAL

SERVICESWill be responsible for all ADMEand pharmacokinetic relatedissues. The successful candidatewill have had experience con-tributing to INDs and NDAs.Significant post-PhD experiencerequired.

mm DIRECTOR, momPRE-CUNICAL STUDIES

Will manage collaborations withuniversities, pharmaceutical com-panies, and contract toxicologyorganizations. DVM/PhD in Tox-icology preferred. PharmD withrelevant experience also con-sidered. High level of ad-ministrative and organizationalskills required.

Houghten Pharmaceuticals, Inc.offers excellent salaries, medical,dental, and 401(k) savings planbenefits; an ideal location nearmajor research centers; and anequity participation at the earlystage of a company with excitingpotential. Please submit yourresume/CV to: Director, HumanResources, Houghten Phar-maceuticals, Inc., 3550 GeneralAtomics Court, San Diego, CA92121. An Equal OpportunityEmployer.

PHARMACEUTICALS

POSITIONS OPEN

BIOTECHNOLOGY POSTDOCTORAL ASSO-CIATE, 1- to 2-year position on NSF-sponsored inter-departmental project on genetic engineering to enhanceproduct recovery in nonchromatographic separations atIowa State University, available immediately. Desirebackground in protein biochemistry or genetic engineer-ing or chemical engineer with related experience. Sendcopy of curriculum vitae and three references to: Dr. C.3. Glatz, Chemical Engineering, 231 Sweeney Hall,Iowa State Universit, Ames, IA 50011. An EqualOpportunity and Affinnative Action Employer.

POSTDOCrORAL RESEARCH ASSOCIATEBROOKHAVEN NATIONAL LABORATORYThe Department of Applied Science has a position

available for a Ph.D. trained in plant molecular biologywith experience in DNA and RA isolation and se-quencing, protein purification, and Northern, Southern,and Western blotting techniques to conduct research ongene expression mechanisms. Experience with eukaryoticalgae and smrcural biology is desirable. The successfulcandidate will join an ongoing research program toelucidate the molecular mechanisms responsible for thephotoregulation of gene expression in eukaryotic algae.

Candidates are asked to foixward curriculum vitae, list ofpublications, andthenames andaddrssesofthree refrnesto: Dr. Paul G. FahDwsk, De ofAppliene, Building 318, Brooven National L aq

oatedUI, Uptn, Long I11973. Eqa Opportnity Employer M/F/D/V

POSTDOCTORAL RESEARCH ASSOCIATEBROOKHAVEN NATIONAL LABORATORYThe Department of Applied Science has a position

available for a Ph.D., preferably in chemistry, withexperience in x-ray absorption spectroscopy. A back-ground in geohemistry and/or environmental chemistryis desirable. The succesul candidate will participate inan interdisciplinary reearch program using synchrotronradiation-based x-ray absorption spectroscopy as an an-alytical tool for detrmining chemical species in studysamples. Duties will indude: (1) measuring x-ray absorp-tion spectra samples at the National Synchrotron LightSource; (2) analyzing the spectral data using computer-based algorithms; and (3) developing, modifying oradapting the necessary computer algorithms for dataanalyis.

Applicants are asked to forward resume, copies ofrelevant publications and names, addresses and telephonenumbers ofthree references to: Mr. Bernard Manowitz,Department of Appl;ied Sdcence, Building 801,Brookhaven NationalLaboratory, Asocated Univer-sities, Inc., Upton, Long Island, NY 11973. EqualOpportunity Employer M/F/D/V.

RESEARCH ASSOCIATEPosition available in the General Clinical Research

Center, Biomedical Mass Spectrometry Facility. Respon-sibilities indude development of new techniques andapplication of stable isotopic methodology to humanbiolo0ical research; teach fellows, students and othertechnicians techniques of biomedical mass spectrometry;supervise the daily operation and quality control of thefacility. Successful candidates will have an advanceddegree (M.S. or Ph.D.) in chemistry or environmentalscience. Experience in research and a publication recordin peer-reviewed journals is required. Send letter ofappication,professional rsum6, names and addresses ofthree references and brief outline of research interests to:Dr. Sree Nair, Metabolic Unit, Deprtment of Med-icine, Given Building, The University of Vermont(WVM), Budhrton, VT 05405. Position open untilfilled. UVM is an Affirmative Action/Equal OpportunityEmployer. Applicationsfrom women and peoplefrom diverseracial, ethnic and cultural backgrounds are encouraged toapply.

RESEAILCH ASSOCIATETRANSGENIC MOUSE FACILITY

Research associate to oversee transFenic mouse facilityat University of Southern Californa Medical School.Experience in production of transgenic mice essential,recombinant DNA techniques desirabk. Highly compet-itive salary commensurate with experience. Send r6sumeto: Ms. Josie Lopez, Norris Cancer Hospital, Room743, 1441 Eastlake Avenue, Los Angeles, CA 90033.

POSITIONS OPEN

RESEARCH ASSOCIATE. Twelve-month positionwith possible extension to 36 months contingent onfunding available in the Agronomy Department to con-duct rescarch on plant gene expression in soybean and/orArabidopsis. Requires Ph.D. in a plant science disciplineand appropriate taining in plant molecular biology (e.g.,DNA cloning, DNA sequence analysis, Plant transforma-tion). Submit r6sumr, transcripts and three letters ofreference by22 June 1992 to: Dr. Robert C. Shearman,Head, Department of Agronomy, Univeity of Ne-braska-Lincoln, P.O. Box 830915, Lincoln, NE68583-0915; telephone: 402472-1555. AffirmativeAction/Equal Opportunity Employer.

RESEARCH ASSOCIATES IN PHYSIOLOGY:Three 3- to 4-year term federal civil service positions infollowing areas: NEUROBIOLOGY to study free rad-ical actions in neurons and glia (Dr. Terry Pellmar);LEUKOCYTE/ENDOTHELIAL CELL PHYSIOL-OGY to study ion channels, signal transduction and/orwound healing (Dr. Elaine Galin); RADIOBIOLOGYto study radiation effects on neural and glial function(Dr. David Livengood). Salary: $21,906 to $42,152 peryear depending on experience. U.S. citizenship required.Information: 301-295-0378. To a ply send curriculumvitae and SF-171 to: Physiology e ent, DNA,Armed Forces Radiobiology R a Institute, Be-thesda, MD 20889. An Equal Opportunity Employer.

RESENARCH ASSOCIATE: The Research Laborato-ries of the Division of Endocrinology, Rhode IslandHospital, seek a Ph.D. with postdoctoral training inmolecular biology to undertake research into regulation ofneural peptide biosynthesis in pituitary and hypothalmusutili:zing DNA/RNA isolation. Northern/Southem blot-ting, in situ hybridization, site-died mutagneis, trans-fection, oligonudeotide probes, PCR, 2-D gels, HPLC,tissue culture.Send curriculum vitae and names of three referees to:

Ivor Jackson, M.D., Director, Division of Endocri-nology, Brown University, Rhode Island Hospital,593 Eddy Street, Providence, RI 02903. Rhode IslandHospital is an Afirtnative Action/Equal Opportunity Em-ployer.

tJ O st ~ WO sto

DEPARTMENT OF AGRICULTURE (USDA)AGRICULTURAL RESEARCH SERVICE (ARS)MICROBIOLOGIST, Virology Cattle Research

Unit, National Animal Disease Center, Ames, Iowa.ARS is seeking a microbiologist to develop tests for

detection of virus contamination in meat and meatproducts. Candidate must have knowledge of basic mo-lecular biology techniques and the skill and ability tooperate instruments used in those techniques, knowledgeand skills in cell culture methods and the ability to isolateand identify pathogenic viruses. Ph.D. is desirable. Mustbe U.S. citizen. Salary is commensurate with experience($32,423 to $60,070 per annum). For information onthe research program and position, contact: Dr. StevenBolin at 515-239-8474. For information on applicationprocedures/forms, contact: Janie Carr at: 301-344-1258.Applications in response to this advertisement should bemarked 2N047. Applications must be postmarked by 30June 1992. Mailing address:

USDA, ARS, Personnel Operaons BranchRoom 325

6305 Ivy LaneGreenbelt, MD 20770

RESEARCH IN EXPERIMENTALPATHOLOGY

AND MOLECULAR PATHOBIOLOGYLEADING TO THE Ph.D.

Expanded faculty and state-of-the-art facilities; sti-pends of $13,000 and up per year including full tuitionwaivers; attractive campus in suburban Westchester doseto New York City; expedited review process and flexibleentrance times for promising candidates. Contact: Dr.Michael B. Stemrman, Profor and Chairman,Department of Experimental Pathology, New YorkMedical College, Valhalla, NY 10595. Telephone:914-993-4625. Equal Opportunity Employer.

SCIENCE * VOL. 256 * 22 MAY 1992

Division of Computer Research and TechnologyNational Institutes of Health

Bethesda, Maryland

SCIENTISTSThe Division of Computer Research and Technology (DCRT), undernew direction, is seeking to expand its research programs inComputational Biosciences and High Performance Computing andCommunications (HPCC). We seek senior level (five years or morePost Doc. research experience) scientists with Ph.D.'s or equivalent,and relevant experience to direct laboratories in the following areas:. Computational Molecular Biology. Computational Structural Biology

(especially x-ray crystallography, multi-dimensionalNMR, protein structure prediction, protein foldingand drug design)

. Biomedical Image Processing (Clinical and Laboratory)* Computationally Intensive Statistics with Biomedical

ApplicationsPositions, salaries, benefits and resources will be commensuratewith training and relevant experience, and will cover the full range ofpossibilities in Federal employment mechanisms.Applicants should send curriculum vitae, bibliography, SF-171,statement of experience and plans to:

Computational Sciences Initiative 1\_" IIV,SDCRT Personnel Q_Building 12A, Room 30139000 Rockville PikeBethesda, MD 20892 OP EP6

DCRT is an Equal Opportunity EmployerApplicants with disabilites are encouraged to apply.

iarsnip in a es ana win nave proven skiiis in

hip and depart

ment of Anatomy plays all aspects of undergraduateteaching in Anatomy and ma *butions to the following

es; Musculoskeletal System (Year lar, Respiratory and

astrointestinal Medicine (Year 2); Head and ce , Renal Medicineand Reproduction (Year 3). The Department also t to the teachingof Anatomy in second and third year Science courses Science. Theintake of Medical students is 160 per year, and approxima Sciencestudents. The Department's postgraduate students include d 10BSc Honours candidates.The Department has 13 academic, 15 technical and 3 administratiIt has an established reputation for excellence in the field of morpho Kteaching and is particularly well equipped for experimental studies incluusing electron microscopy. The Department is enthusiastic to explore ad

cross-discipline activities and encourages staff members to undertake joint reseaand teaching with scientists in other departments and schools.Salary: $A73,800 per annum on appointment, to rise to $A77,900 per annum inJuly 1992 (plus appropriate loadings to medically qualified candidates).Superannuation, travel and removal allowance, and temporary housing assistanceare available.Information on application procedure and further particulars may be obtained fromthe Personnel Officer (Chair Appointments), Monash University, Clayton, Victoria3168, Australia, facsimile 61-3-565 5030. Enquiries of an academic nature may bedirected to the Dean of the Faculty of Medicine, Professor R Porter, facsimile61-3-5654302.Applications should reach the Registrar not later than Friday 26 June 1992. Councilreserves the right to make no appointment or to appoint by invitation at any stage.

&2A~~II 0aI k kqF1 I £OSkqF" tlkqlkvi~

CM-OD_-

<I-

SCol aInTIS cTDrug Metabolism and Pharmacokinetics

SmithKline Beecham, a worldwide leader in pharmaceuticalresearch, is seeking a scientist to join our Clinical Pharmacokineticsgroup.

The Scientist will design, direct and analyze clinical and preclin-ical pharmacokinetic and pharmacodynamic,stu positionoffers substantial opportunity for collab.00t Shwfth entistsinvolved in the discovery and'i'] V Opment .. rapoUtle

agents. As part of diinar;ect teams ,.till

namic principles anr _ tecd-ji .a.p.moprteisare required. rable.. ,s.tr....te semich facilit-osl-t e .d.in suburban

ge, PA. offer a competitive comp-

ensutio.nsfltelselcetn package and a stimulating teamePe r confidential consideration, send your resume to:HR cConnell, M043, Employment Administrator, SmithKlineBeecham Pharmaceuticals, P.O. Box 1539, King of Prussia, PA19406-0939. We are an Equal Opportunity Employer, M/F/H/V.

SBSmithKlne Beecham

Pharmaceuticals

CHAIRMANDEPARTMENT OF PATHOLOGY

Roswell Park Cancer Institute is seeking a Chairman forthe Department of Pathology. This internationally-renowned comprehensive cancer center is entering a

period of renewed growth. Opportunity for research andacademic activity is outstanding. Substantial academiccredentials and an interest in research are highly desired.A faculty appointment will be at the School of Medicineand Biomedical Sciences, SUNY at Buffalo, according tothe level of professional qualifications.

CACER ISTlrUE

Curriculum vitae should be sent to:

Nicholas J. Petrelli, M.D.Chairman, Search Committee

Department of Surgical OncologyRoswell Park Cancer Institute

Elm and Carlton StreetsBuffalo, New York 14263

Roswell Park is an EOE/MFHV

A

POSITIONS OPEN

ATHEROSCLEROSIS/IPOPROTEINRESEARCH

The Health Sciences Department ofMonsanto Corpo-rate Rcsearch is seeking a Ph.D. scientist interested instudying therapeutic intervention in atheroscierosis andrelated cardiovascua diseases. Particular emphasis willbe on regulation of HDL and LDL metabolism, withpreference for those with molecular biology expertise.We are also looking for a team player with provenleadership skills in laboratory and project work. Postdoc-toral experience is also desirablc. The Health SciencesDepartment ofMonsanto is located at a multidisciplinaryresearch campus in suburban St. Louis and conductsboth fundamental and applied research in developingnovel human health care medicines. Please submit cur-rent curriculum vitae, including three references, to:Manager, Human Resurces,Mo CorporateResearch, 02H-KG, 800 North indberg, St. Lou-is, MO 63167. An Equal Opportunity Employer.

RESE3ARCH ANIMAL SCIENTIST, permanentposition, West Lafayette, Indiana. Incumbent will belocated in facilities of Purdue University's Animal Sci-ences Department. Responsible for initiating and devel-opinga research program directed toward understandingthe relationships among physiological parameters, animalbehavior, and well-being. Research would indude iden-tification of internal states of animal cognition/percep-tion and development of indicators of well-bemg forfood-producg animals. Degree in animal science orrelated disciplie, which induded at least 20 semesterhours in animal science, and professional experience inanimal science are requird. Ph.D. and knowiedge ofanimal physiology are desirable. Salary range: $38,861 to$54,607 per annum based on qualifications and experi-ence. For position information contact: Dr. J. RWilcox, 317x494-8074. For the vacancy announcementand application procedures contact: Beverly Webert,301-3M41921. Applications must be marked 2N040and postmarked by 29 June 1992. Incomplete applica-tions will not be considered. ARS is an Equal OpportunityEmployer.

ECOLOGICAL RESEARCH MANAGERUniversity of Georgia's Savannah River Ecology Lab-

oratory (SREL) has an immediate opening for a fu]l-timescience administrtor. The research manager will beresponsible for the daily management, project coordina-tion, and report and proposal preparation for the Wild-life Ecology and Toxicology Division. The individualwill have fiequent interaction with SREL and Universityof Georgia research faculty and administrators and stateand federal personnel Candidates must be U.S. citizensand have a Ph.D. degree and training in ecology orenvironmental science. Knowledge of federal environ-mental regulations and experience in research projectmanagement are desirable. Supervisory and communica-tion skills will be weighed heavily in evaluatin candi-dates. Salary is negotiable, depending on the professionalrecord of the applicants. Applicants should send theirresume, reprints, and the names, addresses and telephonenumbers of four individuals who may be contacted asreferences to:

Dr. Ronald KL ChesserWildlife Ecology and Toxicology Division

Savannah River Ecolky Laboratory

Aiken, SC 29802Applications will be accepted until 7 June 1992. The

University of Georgia is an Equal Opportunity/AfirmnativeAction Institution.

RESEARCH VERTEBRATE ECOLOGISTTo be part of research team at USDA Forest Service,

Rocky Mountain Forest and Range Experiment Station,Laramie, Wyoming. Required: Ph.D. in vertebrate ecol-ogy or related field; ecological modeling and advancedstatistical ability; ability to conduct landscape-level re-search. Knowledge of rangeland/big game ecology desir-able. Formal announcmn will be sent to all respon-dents. Send r6sumi by 15 June to: Dr. Len Rugero,Forestry Sciences Lab, 222 South 22nd Street,Laramie, WY 82070.

POSIONS OPEN

PHYSIOLOGIST, GS-413-13/14, Cardiac RhythmDisturbances. Seeking a physiologist with knowledge ofcardiac electrophysioogy to administer program. Candi-dates must have a Ph.D., M.D., D.V.M. or equivalentdegree and be committed to an administrative, nonlabo-ratory career. Excellent verbal and written communica-tion skills required. Please submit Application for Fed-eral Employment, SF-171, and curriculum vitae to:National Heart, Lung, and Blood Institute, Atten-tion: Ms. Logan, Personnel Office, Building 31,Room 5A28, 9000 Rockvilie Pike, Bethesda, MD20892; telephone: 301-496-6477. Applicants must bea U.S. citizen. National Institutes ofHealth is an EqualOpportunity Employer.

TISSUE TYPING COORDINATORPosition available in Immunogenetics/Bone Marrow

Transplantation Laboratory at Al Children's Hospital(ACH), St. Petersburg, Florida. Responsibilities includeHL-A in m lymphocyte cultures, developmentand standardization ofnew tests and participation in theprocessing of bone marrow for transplantation. M.S. orPh.D. with experience in immunogenetics preferable.ACH is a JCAHO-accredited teaching and research facilityand offixs a compcitivecopnsation pae whichindudes paid L insura e a stim-ulating professional environment for career development.For more information, call: 813-8924139. Equal Oppor-tunity Employer MIF/H/V.

SCIENTIST experienced with amino acid columnchromatography to supervise clinical metabolic disorderlaboratory. Research opportunities available. Knowledgeof dinical inborn erors of metabolism. Must have excel-lent organixational and communication skills. Minimalrequirements: bachelor's degree in biocheniistry or relat-ed area and 5 years of experience. Master's degree and 3years of expenence. Clinical experience and qualificationforNew York City supervisor license in area 051 helpful.Salary: $37,821. Send rsume to: Personnel, New YorkState Institute for Basic Research in DevelopmentalDisabilities, 1050 Forest Hill Road, Staten Island,NY 10314, Reference #702.

ANNOUNCEMIENTSGRANT PROPOSAL SOLICITATION

USDA's Biotechnology Risk Assessment ResearchGrants Program was announced in the Federal Register 17April 1992. Proposals are due 1 June 1992. The programis funded with $1.4 million. Copies of the programnotice and/or the application kit can be requested viaFAX at 202-401488 after business hours and onweekends. Please state whether you are requesting thenotice and/or the kit. Written requests can be mailed to:USDA/CSRS/NBIAP, Suite 330 Aerospace Center,901 D Stroet, SW, Wasington, DC 20250-2200.

KENNETH MORGAREIDGE AWARDTo acknowledge and promote excellence in the area of

toxicology, the International Life Sciences Institute(ILSI) sponsors the Kenncth Morgareidge Award. TheS5000 award will be presented at an international sym-

posium in March 1993 in Hannover, Germany. Therecipient must accept in person and present an overviewof research. Cndidates must be from academia, govern-ment or industry. All documents must be in English.Deadline is 15 Septemb 1992. For application, con-tact: F. DeLuca, ILSI, 1126 16th Street, NW, Wash-ington, DC 20036. Telephone: 202-659-0789.

RE,SEARCH AWARDSThe International Life Sciences Institute (ISLI) Re-

search Foundation announces that one or two awards fora basic research project in TOXICOLOGY or ENVI-RONMENTAL HEALTH (to include human nuti-tion), of up to $100,000 over 3 years, will be made in1993. The purpose ofthe award program is to encourageinnovative new investigators in basic biomedical sciencesto apply modem knowledge and techniques to basicproblems related to comparative toxicology or environ-mental influences on growth, development and aging.The dosing date for applications is 25 August1992. Forfurithr information, wnte: AwardAdmin , ILSIResearch Foundation, 1126 16th Stret, NW, Suite100, Washingtn, DC 20036.

POITIONS OPEN

ENVIRONMENTAL SPECIALIST IVPalatka, Florida. Salary: $33,000 to $49,500. This is a

senior research position tor an environmentl toicologistwho will be responsible for the developnent and manage-ment of a toxnc substances survey for a large estuanneecosystem and for development of remediation plans.Should have experience in sampling and analyzing sedi-ments and tissues for the presence of toxic substances,knowledge ofenvironmentl healh effit of various pol-lutants, and lnowedge of remediation techniques. Abachelor's degree from an accredited colege in toxicology,biology, estuanne ecology or related field and 5 years ofexpenence i environmental toxicology. Send risuni withsource ofadto: TIhe St. Johns RiverWater M tDistrict, Office ofHumanR , P.O. Box 1429,Palatka, FL 32178-1429. Apply by: 5 June 1992.

Equal Employment Opporunity/Ajimiative ActionEnplor/Vretran Pfrence

DRUG-FREE WORKPILACE

SITUATIONS WANTED

Ph.D. IN MEDICAL MYCOLOGY, 10 years ofresearch and process development xperien in femecnta-tion technology and bioengineering of yeast metabolites(edlanol, SC and glycerol), training in ycastge cengnering and biosensors. Interestd in a posi-tion in academic or industal concems. Fields of interest:Pathogenesis of HIV and drug developmenVyeast genet-icsinldustrial process developlent of microbial nmtabo-lites. Contact: 223 Schrade od, #1A, BardffMan-or, NY 10510. Telphone: 914-41-8192.

MIAKETPLACE

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SCIENCE * VOL. 256 * 22 MAY 19921246

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and muscle types (107kD) L yiUsed to form conjugates that contain hindered disulfidebonds and exhibit enhanced stability in vivo

OWN 21. Faster than 'shaker" method I'. Functions as 'reverse* affinity matrix3. Lacks proline rich sequence found in hinge region of IgG and IgAt. Fast blocker;. Carbonyl-reactive crosslinker that is iodinatable and photoreactive J'. Kit used to identify purity of cell lineI. Previously, no product available for one-step purificatioh of thisI. Described by Young as novel substrate for HRPI. Plays important role in cell adhesion and extensions3.Easy way to radiolabel your cell surface proteins

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Can be used for histology with acetone-fixed snap frozen tonsil1. Substrate for alkaline phosphatase in immunoblotting applications

low you can win $10,000 (U.S. dollars)Solve the puzzle. All of the answers can be found on pages 1-56 in the New Products Secti1of your 1992 Pierce ImmunoTechnology Catalog and Handbook. Only one entry per person.Photocopies of this puzzle will be accepted.Complete the information at right Al information must be induded.Place completed puzzle in an envelope and mall to: Pierce Puzzle, P.O. Box 117, Rockford, IL61105. All envelopes must be postmarked no later than August 1, 1992.If more than one entrant correctly solves the puzzle, the winner will be selected in a randomdrawing on August 15, 1992. Winner will be notified no later than September 1, 1992.Al entrants must be researchers at least 21 years of age and employed by an industrial, academic,clinical or governmental research facility. Employees of Pierce Chemical, Pierce Europe, Perstorp,Pierce Agents/Distributors or family members of aforementioned are ineligible.AU federal, state and local laws and regulations apply; void where prohibited by law.Winner has the option to donate the money to a charity of choice.Taxes are the sole responsibility of the winner. mERC ENo purchase necessarytk win& n.--

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