introductory phylogenetics and the blue line in dna subway sheldon mckay dnalc, cold spring harbor...
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![Page 1: Introductory Phylogenetics and the Blue line in DNA Subway Sheldon McKay DNALC, Cold Spring Harbor Laboratory March 28, 2012](https://reader036.vdocuments.mx/reader036/viewer/2022062517/56649e9c5503460f94b9d54c/html5/thumbnails/1.jpg)
Introductory Phylogenetics and the Blue line in DNA Subway
Sheldon McKay
DNALC, Cold Spring Harbor Laboratory
March 28, 2012
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Why is the tree of life important?
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“Knowledge of evolutionary relationships is fundamental to biology, yielding new insights across the plant sciences, from comparative genomics and molecular evolution, to plant development, to the study of adaptation, speciation, community assembly, and ecosystem functioning.”
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Tree of Life: Classification and Phylogeny
Image from http://tolweb.org/tree
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We have a tendency to put things into categories.
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AB C
DE
F
Classifications often reflect evolutionary history
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Phylogenetic trees are representations of evolutionary history
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evolution
phylogen*
2007
phylogen*29,28238%
evolution77,816100%
ecolog*62,76182%
ecolog*
Figure courtesy of Brian Omeara 7
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What is the difference between taxonomy and phylogeny?
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(E) human
Consider primates: Do humans make up a monophyletic group?
Hylobatidae Pongidae
Hominidae
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Phylogeny based on a globin pseudogene suggests thathumans and chimpanzees make up a single monophyletic group
outgroup
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Are there practical uses for phylogenetics?
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Consider the “Tripoli Six”
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Are there practical uses for phylogenetics?
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Six Medical aid workers who arrived in Libya were accused of causing an HIV outbreak amongst 400 children at a Libyan hospital.
Forensic phylogenetic analysis showed that the strains of HIV and HCV were prevalent in the hospital well before the team arrived in 1990
The six were convicted and sentenced to death anyway. They were laterre-tried and sentenced to life. They were eventually released.
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Trait Evolution
Image courtesy of Brian Omeara
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Rotifera Platyhelminthes Annelida Mollusca Nematoda Arthropoda Echinodermata Vertebrata
gain gain
Are the “Camera eyes” in molluscs and vertebrates homologous?
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http://phe.rockefeller.edu/barcode/blog/wp-content/uploads/2006/12/titmice-tree2.gif
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Phylogenetic tree as a reference for barcode-based species identification
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? Barcode x
Phylogenetic tree as a reference for barcode-based species identification
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The Blue Line
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