INTRODUCTION TO PATHOLOGY

Dr Heyam Awad

MD, FRCPATH, Jordanian Board

LECTURE 1

Introduction to pathology

Today’s lecture

• Introduction aiming at:

1.Introducing you to the course.

2. What is pathology ?

3. What do pathologists do?

The course

• Two credit hours course

• Three main subjects will be covered:

1. Cell injury

2. Inflammation

3. Neoplasia

reference

- Robbins basic pathology, Kumar Abbas and Aster, 10th edition.

- My slides are a summary of the book!

Course design!

topic instructor No of lectures Book chapter

Cell injury Dr Heyam Awad 5 1

Inflammation and repair Dr Mousa Abbadi 10 2

neoplasia Dr Maha shomaf 10 5

My lectures

• Two sets of slides:

• 1.A detailed one which you need to study from

This will be on my web page and on the e learning site before the lecture day .

2. A FUN version that includes mainly pictures.. This will aid us discussing the subject

Do we need sheets?.. How to study?

assessment

*Mid term.. 40 marks ..Around week 7material: cell injury and inflammation

*Final exam.. 50 marksmaterial: repair and neoplasia

*Attendance marks.. 10please note: school of medicine is strict

about attendance..

The best way to deal with my lectures!

• 1. attend the lectures and try to understand

• 2. read the slides carefully.. They are detailed.. I put everything you need for the exam there

• 3. I encourage you to read the book: chapter 1

• 4. keep checking the e-learning, I’ll put resources and sample questions there.

• KEEP CALM AND ENJOY

MY RULES!!!

• First: your rights

• To be respected

• To enjoy each 50 minutes here

• To understand

• And: please ask questions.. Give comments.. And challenge me!

Remember:

Lecture RULES: your duty!

• Give me your full attention!

What about coffee?

Contact details

• Office hours: 2-3 daily

• My office is in the hospital, third floor

• You can also see me outside the office hours, if I’m not in the office I’ll be in the histopathology department in the same floor(third)

• E mail: h_awad@ju.edu.jo

• : heyamawad2000@yahoo.com

• Also: keep checking e learning for announcements.

What is pathology?

• Patho = disease

• Logy = study

• So pathology is the study of disease =علم االمراض

Pathology studies three main aspects of the disease process:

• Etiology

• Pathogenesis

• morphology

Etiology.. The “why” question

• = the origin of disease= the underlying cause.

Pathogenesis.. “HOW”

• Steps in the development of disease.

• Describes how etiologic factors trigger cellular and molecular changes that give rise to functional and structural abnormalities.

• Disease occur in a multistep organized fashion..

pathogenesis

• Message: as a doctor you need critical thinking, splitting things into precise steps and stages

morphology

• The changes seen on tissues and organs that help diagnosing the disease

• Gross= macroscopic morphology: changes seen by naked eye

• Microscopic morphology: changes seen under the microscope.

Gross morphology .. Can you describe ?

morphology

Histopathology is fun..

What do pathologists do?

Sample obtained.. how

Sample received in lab

HOW DOES THESE SAMPLES CHANGE INTO GLASS SLIDES???

Grossing = cutting the sample

Processing to a paraffin block

Cutting.. By a microtome

Staining the slide

Ready to be read by the pathologist

The pathology report

• We convey what we see under the microscope in a written report.

• The report includes macroscopic ( gross) and microscopic description.

• It gives you information about: the diagnosis, the prognosis and probably the underlying cause.