introduction of the ois index

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Introduction: OIS@AAO Chicago October 13, 2016 Michael E. Lachman © Copyright 2016 EyeQ Research and Healthegy/OIS

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Page 1: Introduction of The OIS Index

Introduction:

OIS@AAO ■ Chicago ■ October 13, 2016

Michael E. Lachman

© Copyright 2016 EyeQ Research and Healthegy/OIS

Page 2: Introduction of The OIS Index

October 13, 2016 ■ Page 2

Stock Market Indices

US Broad Market Indices Dow Jones Industrial Average S&P-500 Russell 3000

International Market Indices Nikkei 225 (Tokyo), FTSE 100 (London), DAX Index (Frankfurt)

Market Sector Indices Dow Jones Transportation and Utility Averages NASDAQ Biotechnology Index

Page 3: Introduction of The OIS Index

October 13, 2016 ■ Page 3

Introducing the OIS Index

October 1, 2016

1,000.00

Page 4: Introduction of The OIS Index

October 13, 2016 ■ Page 4

OIS Index Methodology

Mid-Cap and Small-Cap Ophthalmic Companies Publicly Traded ≥ 50% Ophthalmology Initial Composition: 70% Biopharma, 30% Ophthalmic Device

Market Cap Weighted, with Limits Largest Companies Capped at 10% of Total Index Value Others Capped at 8% and 6%

Updated and Rebalanced Quarterly IPOs, Acquisitions, Share Counts 30 - Eleven = 29

Page 5: Introduction of The OIS Index

October 13, 2016 ■ Page 5

OIS Index ComponentsMkt. Cap

Raw Pct.

Adj. Pct.

C. Zeiss Meditec $3,091 24% 10.0%Spark Therap. $1,839 14% 8.0%Ophthotech $1,642 13% 8.0%Glaukos $1,246 9.6% 8.0%Aerie Pharma. $1,102 8.5% 8.0%Molecular Part. $529 4.1% 6.0%Omeros $477 3.7% 6.0%STAAR Surgical $380 2.9% 5.8%Clearside Bio. $356 2.8% 5.4%Inotek Pharma. $255 2.0% 3.9%NicOx $231 1.8% 3.5%GenSight Bio. $191 1.5% 2.9%AGTC $177 1.4% 2.7%Ocular Therap. $171 1.3% 2.6%Adverum Bio. $170 1.3% 2.6%

Mkt. Cap

Raw Pct.

Adj. Pct.

Second Sight $149 1.2% 2.3%Iridex $147 1.1% 2.2%Thrombogenics $116 0.9% 1.8%pSivida $103 0.8% 1.6%Aldeyra Therap. $98 0.8% 1.5%Alimera Sci. $94 0.7% 1.4%Ohr Pharma. $91 0.7% 1.4%Opthea $84 0.7% 1.3%Presbia $58 0.5% 0.9%Imprimis $50 0.4% 0.8%NovaBay Pharm. $46 0.4% 0.7%TearLab $34 0.3% 0.5%Eyegate Pharm. $16 0.1% 0.3%Escalon Med. $5 .04% .08%

Page 6: Introduction of The OIS Index

October 13, 2016 ■ Page 6

OIS Index – Six Month Performance

April 1 – October 1, 2016 OIS Index +22%

Total US Market +6%

US MedicalDevices + 19%

NASDAQBiotechnology Index + 11%

Total US market based on Russell 3000 Index (^RUA)US medical devices based on iShares US Medical Devices ETF (IHI) Equity valuations from MarketXLS

Page 7: Introduction of The OIS Index

October 13, 2016 ■ Page 7

OIS Index – Key Drivers of Performance

April 1 – October 1, 2016

Aerie PharmaceuticalsGlaukosSpark TherapeuticsClearside BioMedical

OmerosAGTCMolecular Partners

Page 8: Introduction of The OIS Index

We Invite Your Feedback… Thank You! Michael E. Lachman ■ [email protected]

Craig Simak ■ [email protected]

© Copyright 2016 EyeQ Research and Healthegy/OIS

Page 9: Introduction of The OIS Index

October 13, 2016 ■ Page 9