introduction of neurodegenerative diseases
TRANSCRIPT
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PRESENTED BY-
CHARU PUNDIR
(09270300011)
B.PHARM
DEPARTMENT OF PHARMACEUTICAL SCIENCES,
S.B.S.P.G.I, BALAWALA DEHRADUN
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NERVOUS SYSTEM NEURONS CELL BODIES AXONS AND DENDRITES NERVE IMPULSE TYPES OF NERVES- SENSORY , MOTOR
AND MIXED SYNAPSE NEUROTRANSMITTERS
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CENTRAL NERVOUS SYSTEM
BRAIN CELLS- ASTROCYTES, OLIGODENDROCYTES, MICROGLIA AND EPENDYMAL CELLS.
MENINGES- DURA MATER, PIA MATER AND ARACHNOID MATER.
VENRICLES OF BRAIN- RIGHT AND LEFT VENRICLE, THIRD VENTRICLE AND FOURTH VENTRICLE.
CSF- WATER, MINERAL SALTS, GLUCOSE, PLASMA PROEINS, CREATININE,
UREA AND A FEW LEUCOCYTES.
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BRAIN CEREBRUM- LOBES (FRONTAL, PARIETAL,
TEMPORAL AND OCCIPITAL), BASAL GANGLIA, THALAMUS, HYPOTHALAMUS.
MIDBRAIN PONS MEDULLA OBLONGATA THE BRAIN
STEM CEREBELLUM
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SPINAL CORD
SPINAL NERVES- CERVICAL, THORACIC, LUMBAR, SACRAL AND COCCYGEAL
GREY MATER WHITE MATER
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PNS 31 PAIRS OF SPINAL NERVES 12 PAIRS OF CRANIAL NERVES THE AUTONOMIC NERVOUS SYSTEM
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ANS SYMPATHETIC PARASYMPATHETIC
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INVESTIGATIONS IN CNS VERTICULOGRAPHY CAT SCAN MRI PNEUMOENCEPHALOGRAPHY CEREBRAL ANGIOGRAPHY
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NEURODEGENRATIVE DISORDERS OF BRAIN ALZHEIMER PRION ALS HUNTINGTON PARKINSON
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REASONS OF NEURONAL DEATH OXIDATIVE STRESS EXCITOTOXICITY PROTEIN MISFOLDING INFECTIOUS ORGANISM GENETICS
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ALZHEIMER PRESENILE
DEMENTIA ARISES SHARPLY
WITH AGE LOSS OF
NEURONS SHORT TERM
MEMORY LOSS COGNITIVE DEFICITS
DEPOSITION OF BETA AMYLOID PLAQUES
NEUROFIBRILLARY TANGLES- TAU PHOSPHORYLATION
SECRETASES CAUSES APP CLEAVAGE INTO AB40 AND AB42 CAUSING AMYLOID FORMATION
DECREASE ACH LEVELS
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TREATMENT CHOLINERGICS ANTIOXIDANTS NSAIDS STATINS HORMONE REPLACEMENT THERAPY DIET MODIFICATION
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DRUGS LADOSTIGIL DIMEBOLIN GINKO BILOBA SIMVASTATIN VALPROATE DHA TACRINE RIVASTIGMINE DONEPAZIL
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HUNTINGTON INHERITED
AUTOSOMAL DOMINANT DISORDER
JERKLIKE MOVEMENTS
PARANOIA DELUSIONAL STATES IMPAIRMENT OF
RAPID EYE MOVEMENT
TREATMENT- FLUOXETINE, CARBAMAZEPINE, CLOZAPINE, QUETIAPINE, RESERPINE, VALPROIC ACID
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PRION DISEASE SPONGIFORM
ENCEPHALOPATHY PROPAGATE
THROUGH INFECTIOUS AGENT
FORMATION OF PRION RODS, ALPHA SY NUCLEIN FIBRILLS, PRP AMYLOID PAQUES, AND LEWY BODY
TREATMENT- QUINACRINE, CHLORPROMAZINE
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ALS DISTURBENCE IN
MOTOR NEURON OF VENTRAL HORN OF SPINAL CORD AND CORTICAL NEURON
SPASTICITY MUSCLE WEAKNESS FASCICULATIONS RESPIRATORY
COMPROMISE
TREATMENT- RILUZOLE, BACLOFEN,
TIZANIDINE, CLONAZEPAM
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PARKINSON CHARACTERISED
BY MOVEMENT DISORDERS
TREMOR AT REST MUSCLE RIGIDITY SUPRESSION OF
VOLUNTARY MOVEMENTS
SHUFFLING GAIT, HYPOKINESIS
ENVIRONMENTAL TREGERS
PROTEIN MISFOLDING AND AGGREGATION
EXCITOTOXICITY OXIDATIVE STRESS APOPTOSIS DEGENERATIVE LESION
IN SN-PC AND DECREASED DOPAMINERGIC INPUT
IMBALANCE BTW DA AND ACH
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TREATMENT MEDICATION- COMT INHIBITORS, MAO
INHIBITORS, DOPAMINERGICS, ANTICHOLINERGICS
ADJUNCT THERAPIES- PHYSIOTHERAPY, OCCUPATIONAL THERAPY, SPEECH AND LANGUAGE THERAPY
SURGICAL TREAMENTS AYURVEDIC APPROACH DIET CELL THERAPY
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DRUGS ENTACAPONE TOLCAPONE LEVODOPA- CARBIDOPA ATMAGUPTA- HERB
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THANKS TO MY SUPERVISOR PROF. DR. VEERMARAM (H.O.D)DEPARTMENT OF PHARMACEUTICALSCIENCES,S.B.S.P.G.I,BALAWALADEHRADUN