intravenous anesthetic agents
DESCRIPTION
Induction of anesthesia (smother and more rapid than inhalational agents)Maintenance (alone or with inhalational agents)Sedation during regional anesthesia Sedation in intensive care unitTreatment of status epilepticusTRANSCRIPT
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Intravenous anesthetic agents
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Intravenous Anesthetics
Barbiturates Benzodiazepines OpioidsMiscellaneous
drugs
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Uses
1. Induction of anesthesia (smother and more rapid than inhalational agents)
2. Maintenance (alone or with inhalational agents)
3. Sedation during regional anesthesia
4. Sedation in intensive care unit
5. Treatment of status epilepticus
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Barbiturates (thiopenton or thiopental)
Indications:
1. Induction of anesthesia
2. Maintenance of anesthesia (but has cumulative effects)
3. Treatment of status epilepticus
4. Reduction of intra-cranial pressure (ICP)
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Adverse effects:1. Hypotension2. Respiratory depression3. Tissue necrosis (if injected extra-vascular)4. Laryngospasm5. Bronchospasm (avoid in asthma)6. Thrombophlibitis (less common in 2.5% conc.)7. Allergic reactions 1 in 14000-200008. Intra-arterial injection (lead to sever
vasospasm and sever pain it may lead to gangrene of the limb, treatment by keeping the cannula in and inject papeverine 20 mg, heparin and fluid, using 2.5% conc. Is safer)
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Contra indications:
1. Airway obstruction (epiglottis or pharyngeal tumours)
2. Porphyria
3. Previous hypersensitivity to this drug
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Benzodiazepines (Diazepam, Midazolam)
Indications:1. Sedation during regional anesthesia2. Radiological procedures (children, anxious
persons)3. Endoscopy4. ICU5. Supplementation to general anesthesia6. Amnesia7. Status epilepticus
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Adverse effects:
1. Prolong duration (diazepam)
2. Painful on injection (diazepam)
3. Hypotension if used with other agents like opioids
4. Dependence
5. Respiratory depression in over dosage
Contraindications:
Early pregnancy (teratogenic effect)
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Opioids
Agonist Morphine, Pethidine, Tramadol
Fentanyl & Al, Remi, Su (fentanil)
Agonist-AntagonistPentazocine, Nalburphine
AntagonistNalaxone
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Indications:
1. Provision of analgesia before or after surgery
2. Induction of anesthesia and maintenance of anesthesia in patients with severe cardiac dysfunction
3. Inhibition of reflex sympathetic nervous system activity
4. Supplementation of inhalational anesthetics being used for maintenance of anesthesia
5. Provide post operative analgesia by injecting it to the subarachnoid or epidural space
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Adverse effects:
• On cardiovascular system:
1. Orthostatic hypotension (decreased sympathetic nervous system tone to peripheral veins)
2. Release of histamine (Morphine)
3. Bradycardia (Sufentanil)
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• On Ventilation:
1. Increase resting Paco2
2. Decrease of responsiveness to the ventilatory stimulation of CO2
3. Decreased rate of breathing but tidal volume is often increased
4. Spasm of thoraco-abdominal muscles
• Stiff chest syndrome
• Spasm of biliary smooth muscles which leads to pain also spasm of the sphincter of Oddi
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• On CNS
1. Miosis
2. Stimulation of Dopamine receptors in the chemoreceptor trigger zone which cause nausea and vomiting
3. Addiction
• Enhancement of bladder sphincter tone which lead to urine retention
• Decrease peristalsis
• Increase the tone of the pyloric sphincter which lead to delayed gastric emptying
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Preemptive analgesia
Injection of an opioid before painful surgical stimulation occurs this may decrease the subsequent amount of opioid required in the postoperative period to provide analgesia
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Morphine (10, 15mg)• Can be Administered by variety of routes• Has active metabolites• Risk of accumulation in patient with renal impairment• Avoid in asthma (histamine release)
Pethidine (100mg)• Shorter acting• Its metabolites has long half life with risk of
accumulation in patient with renal impairment, also the metabolites are neurotoxic and result in grand mal seizures
• Avoid in patient with history of epilepsy
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Tramadol (100mg)• Analgesic efficacy around one tenth that of
morphine• Avoid in patient with history of epilepsy• Useful for elderly• Useful For Patient-Controlled Analgesia (PCA)
Fentanyl (100μg )• Very potent opioid used primarily for intra-
operative analgesia• Useful drug for PCA• Cause respiratory depression
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Alfentanil (100μg )• Ultra short-acting potent opioid used for intra-
operative analgesia• Limited use in the post operative period • Cause respiratory depression
Sufentanil• Is closely related in structure to fentanyl • 5-10 times more potent than fentanyl and slightly
shorter duration
Remifentanil• Ultra short acting opioids• The duration of action is short with no residual
effects
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Agonist-Antagonist
Those drugs have limited analgesic properties (ceiling effect) above which increasing doses do not produce additional anesthesia, they usually used for treatment of addiction
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Antagonist
Is used as a short acting opioid antagonist because of its short duration of action opioid terminated depression may return when effect of Nalaxone have terminated
Nalaxone may precipitate the sympathetic drive of unrelieved pain (tachycardia, hypertension, arrhythmias-----etc.)
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Miscellaneous drugs
Propofol
Etomidate
Ketamine hydrochloride
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PropofolIndications:• Induction of anesthesia when rapid early recovery of
consciousness is indicated• Sedation during regional anesthesia• Sedation in ICU• Total intravenous anesthesiaAdverse effects:• Cardiovascular depression • Respiratory depression• Excitatory phenomena (convulsion, myoclonus)• Pain on injection• Allergic reactionContra indication:• Airway obstruction• Hypersensitivity
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EtomidateIndications:• Used in patient with cardiovascular disease
(cardiovascular stable)• Suitable for out patient anesthesiaAdverse effects:• Excitatory phenomena (involuntary movements, hiccups,
cough)• Pain on injection• Nausea and vomiting• Venous thrombosisContraindications:• Airway obstruction• Porphyria• Adrenal insufficiency• Long term duration
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Ketamine hydrochloride:Indications:• Shocked patient• Paediatric anesthesia• Difficult locations (at accident site, wars)• Analgesia And sedation (wound dressing change)• In ICU• In developing countries (where anesthesia equipments
and trained staff are in short supply)
Adverse effects:• Emergence delirium, nightmares and hallucinations• Hypertension and tachycardia • Prolong recovery• Salivation• Increase intra-cranial pressure