integumentary system (skin) skin (integument)facweb.northseattle.edu/jdahms/fall07/lectures/lecture...

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1 Lecture 5 Integumentary System Topics Structure and function of integument Epidermis Dermis Hypodermis Skin color Skin cancer Accessory structures of Integument Temperature regulation Aging Skin Injury and regeneration Integumentary System (skin) Skin (Integument) Consists of three major regions – Epidermis – outermost superficial region – Dermis – middle region these two together make up the cutaneous membrane) – Subcutaneous region (aka Hypodermis or (superficial fascia) – deepest region Also includes all the accessory structures found in the skin (hair, glands, etc.) What are some of the functions of skin? • Protection Excretion (salts, water, wastes) Maintenance of body temperature Metabolism (Vitamin D 3 ) Storage (lipids, blood reserve) Detection of sensation Note: skin keeps water in as well as keeping it out Figure 5.1 Epidermis Dermis Hypodermis (superficial fascia) Hair root Hair shaft Pore Dermal papillae (papillary layer of dermis) Meissner's corpuscle Free nerve ending Reticular layer of dermis Sebaceous (oil) gland Arrector pili muscle Sensory nerve fiber Eccrine sweat gland Pacinian corpuscle Artery Vein Adipose tissue Hair follicle receptor (root hair plexus) Hair follicle Eccrine sweat gland

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Page 1: Integumentary System (skin) Skin (Integument)facweb.northseattle.edu/jdahms/Fall07/Lectures/Lecture 5...1 Lecture 5 Integumentary System Topics zStructure and function of integument

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Lecture 5

Integumentary System

TopicsStructure and function of integument

EpidermisDermisHypodermis

Skin colorSkin cancerAccessory structures of IntegumentTemperature regulationAging Skin Injury and regeneration

Integumentary System (skin) Skin (Integument)

• Consists of three major regions– Epidermis – outermost superficial region– Dermis – middle regionthese two together make up the cutaneous membrane)– Subcutaneous region (aka Hypodermis or

(superficial fascia) – deepest region• Also includes all the accessory structures

found in the skin (hair, glands, etc.)

What are some of the functions of skin?

• Protection• Excretion (salts, water, wastes)• Maintenance of body temperature• Metabolism (Vitamin D3)• Storage (lipids, blood reserve)• Detection of sensation

• Note: skin keeps water in as well as keeping it out

Figure 5.1

Epidermis

Dermis

Hypodermis(superficialfascia)

Hair root

Hair shaft

Pore

Dermal papillae (papillary layerof dermis)

Meissner's corpuscle

Free nerve endingReticular layer of dermis

Sebaceous (oil) gland

Arrector pili muscleSensory nerve fiberEccrine sweat glandPacinian corpuscle

ArteryVein

Adipose tissue

Hair follicle receptor(root hair plexus)

Hair follicleEccrine sweatgland

Page 2: Integumentary System (skin) Skin (Integument)facweb.northseattle.edu/jdahms/Fall07/Lectures/Lecture 5...1 Lecture 5 Integumentary System Topics zStructure and function of integument

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Parts of the Cutaneous Membrane

• Outer epidermis:– superficial epithelium (epithelial tissues) Composed of

keratinized stratified squamous epithelium, consisting of four distinct cell types and four or five layers

– Cell types include keratinocytes, melanocytes, Merkel cells, and Langerhans’ cells

– Outer portion of the skin is exposed to the external environment and functions in protection

• Inner dermis:– connective tissues (what are they?)

Epidermis

• Avascular stratified squamous epithelium• Nutrients and oxygen diffuse from

capillaries in the dermis to lower layers of epidermis

Cells of the Epidermis

• Keratinocytes – produce the fibrous protein keratin

• Melanocytes – produce the brown pigment melanin; cell bodies in upper dermis that have extensions into the epidermis

• Langerhans’ cells – epidermal macrophages that help activate the immune system

• Merkel cells – function as touch receptors in association with sensory nerve endings

Organization of the Epidermis:

Figure 5–2

Layers of the Epidermis

Figure 5.2b

The thick of it

Thin Skin• Covers most of the

body • Has 4 layers of

keratinocytes

Thick skin• Covers the palms of

the hands and soles of the feet

• Has 5 layers of keratinocytes

Page 3: Integumentary System (skin) Skin (Integument)facweb.northseattle.edu/jdahms/Fall07/Lectures/Lecture 5...1 Lecture 5 Integumentary System Topics zStructure and function of integument

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Layers of the epidermis are known as “strata” Layers of the Epidermis

Top: Free surface of skin- stratum corneum- stratum lucidum- stratum granulosum- stratum spinosum- stratum germinativum

Bottom: Basal lamina

1. Stratum Germinativum (Basale)

• The “germinative layer” (or basal layer):– Deepest epidermal layer firmly attached to the

basal lamina and dermis via hemidesmosomes

– Consists of a single row of the youngest keratinocytes along with projections of melanocytes

– Cells undergo rapid division,

Structures of Stratum Germinativum

• Epidermal ridges –– cause the pattern of your fingerprints; – created by presence of:

• Dermal papillae (tiny mounds):– increase the area of basal lamina– Function?

Fingerprints are epidermal ridges

Figure 5–4

• Which themselves are negative images of the dermal papilla

2. Stratum Spinosum

• “spiny layer”• 8-10 cells (keratinocytes) thick• Immature keratinocyte cells continue to

divide, then shrink until cytoskeletons stick out (spiny), a system of intermediate filaments attached to desmosomes

• Melanin granules and Langerhans’ cells are abundant in this layer

Page 4: Integumentary System (skin) Skin (Integument)facweb.northseattle.edu/jdahms/Fall07/Lectures/Lecture 5...1 Lecture 5 Integumentary System Topics zStructure and function of integument

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3. Stratum Granulosum

• “grainy layer”• Consists of 3-5 cell layers of keratinocytes• Cells stop dividing in this layer, dehydate

and produce tons of proteins:– Keratohyaline– Keratin

4. Stratum Lucidum

• The “clear” layer• Only found in thick skin• Covers granulosum• Consists of a few rows of flat, dead

keratinocytes filled with keratin• The layer appears, ironically, very thin in

slides• Probably functions to hold on the thicker

corneum layer above

A note on thick vs. thin skin

• Thick skin has an extra layer (lucidum) but that is NOT the reason that it is thicker than thin skin.

• The reason is the other layers are thicker in thick skin than in thin skin, esp. s. corneum

5. Stratum Corneum

• The “horn layer”:• exposed surface of skin • 15 to 30 layers of keratinized cells• Accounts for ¾ of epidermal thickness• water resistant (not water proof!)• Protects from abrasion and penetration• shed and replaced every 2 - 4 weeks

Skin is often called a cornified epithelium

Skin Life Cycle

• It takes 15–30 days for a cell to move from stratum germinosum to stratum corneum

Layers of the Epidermis

Figure 5.2b

Page 5: Integumentary System (skin) Skin (Integument)facweb.northseattle.edu/jdahms/Fall07/Lectures/Lecture 5...1 Lecture 5 Integumentary System Topics zStructure and function of integument

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Dermis consists of connective tissue The Dermis• Deeper part of cutaneous layer• Located between epidermis and subcutaneous

layer• Anchors epidermal accessory structures (hair

follicles, sweat glands) • Contains strong, flexible connective tissue• Cell types include fibroblasts, macrophages, and

occasionally mast cells and white blood cells• Has 2 components:

– outer papillary layer– deep reticular layer

The Papillary Layer

• Consists of areolar tissue with collagen and elastic fibers

• Contains smaller capillaries, lymphatic vessels, and sensory neurons

• Has dermal papillae projecting between epidermal ridges

The Reticular Layer

• Consists of dense irregular connective tissue• Accounts for approximately 80% of the thickness

of the skin• Contains larger blood vessels, lymph vessels,

and nerve fibers• Collagen fibers in this layer add strength and

resiliency to the skin• Elastin fibers provide stretch-recoil properties

Contains collagen and elastic fibers

The Subcutaneous Layer

• Subcutaneous layer (superficial fascia or hypodermis): – loose connective tissue - areolar and adipose– connected to the reticular layer of dermis by

connective tissue fibers– stabilizes the skin– allows separate movement – Insulates and stores energy– location of hypodermic injections

Skin Color

• Skin color depends on three pigments:– Melanin -yellow to reddish-brown to black

pigment, responsible for dark skin colors• Freckles and pigmented moles – result from local

accumulations of melanin• Produced by melanocytes just below stratum

germinativum• Stored in transport vesicles (melanosomes)• Projections extend up into epidermal layers• Some transferred to keratinocytes

– Hemoglobin in red blood cells – Carotene (minor factor)

Page 6: Integumentary System (skin) Skin (Integument)facweb.northseattle.edu/jdahms/Fall07/Lectures/Lecture 5...1 Lecture 5 Integumentary System Topics zStructure and function of integument

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Melanocytes

Figure 5–5

Function of Melanocytes

• Ultraviolet (UV) radiation:– causes DNA mutations and burns which lead

to cancer and wrinkles• Melanin protects skin from sun damage• Pigment molecules absorb UV and diffuse

it, preventing it from penetrating to the DNA of cells in the strata germinativumand spinosum

Melanocytes

• Skin color depends on amount of melanin production per melanocyte, not number of melanocytes.

Capillaries and Skin Color

• Oxygenated red blood contributes to skin color: – blood vessels dilate from heat, skin reddens– blood flow decreases, skin pales– corpses appear pale and lighter because they

lack this coloration

Cyanosis

• Bluish skin tint• Caused by severe reduction in blood flow

or oxygenation• The veins appear blue when blood is

deoxygenated but deoxegenated blood is NOT blue – it is darker red

Illness and Skin Color

• Jaundice:– buildup of bile produced by liver– yellow color

• Addison’s disease:– and other diseases of pituitary gland– skin darkening

• Vitiglio:– loss of melanocytes– localized loss of color

Page 7: Integumentary System (skin) Skin (Integument)facweb.northseattle.edu/jdahms/Fall07/Lectures/Lecture 5...1 Lecture 5 Integumentary System Topics zStructure and function of integument

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Vitamin D• The “sunshine vitamin”• Epidermal cells produce cholecalciferol

(vitamin D3) in the presence of UV radiation

• Liver and kidneys convert vitamin D into calcitriol which aids in absorption of calcium and phosphorus at the intestines

• Insufficient vitamin D:– can cause rickets– Symptoms?

Skin Damage

• Sagging and wrinkles (reduced skin elasticity) are caused by loss (or decresedproduction) of collagen and elastin by fibrolasts, due to:– dehydration– age– hormonal changes– UV exposure

Skin Cancer

Figure 5–6

Skin Cancer

• The three major types of skin cancer are:– Basal cell carcinoma (s. germinativum)– Squamous cell carcinoma (s. spinosum)– Melanoma

• The vast majority of all skin cancers are of the first two types (basal and squamous)

• They rarely metastasize and can be taken care of by excision; thus they are not included in most cancer statistics

Melanoma

• Cancer of melanocytes is the most dangerous type of skin cancer because it is:– Highly metastatic– Resistant to chemotherapy

• Kind of ironic because they evolved to protect basal cells, but basal cell cancer has a much better prognosis

Skin Cancers

Figure 5.7a–c

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Skin color tradeoff?

• Vitamin D is necessary for bone strength, but if there is not much UV (high latitudes), individuals with a lot of melanin have trouble getting enough Vit D. But when UV is plentiful, they are better protected from skin cancer.

• On the other hand, in places with a lot of UV (low latitudes), people with very little melanin are at high risk of skin cancer. But they are more likely to get enough UV from the sun in low UV regions.

Accessory Structures of the Integument

• Are of epidermal lineage (cells are modified epithelial cells)

• “Originate” in the dermis (this is where you look to find them)

• Extend through the epidermis to skin surface:– Hair ad follicles– nails– multicellular exocrine glands (sebaceous, sweat)

The Hair Follicle

• Is located deep in dermis• Is made of epidermal tissue• Produces nonliving hairs • Is wrapped in a dense connective-tissue

sheath• Base is surrounded by sensory nerves

Structures of Hair and Follicles

Figure 5–9a

Structures of Hair

• Arrector pili: – involuntary smooth muscle – causes hairs to stand up– produces “goose bumps”

• Sebaceous glands: – lubricate the hair– control bacteria

Properties of hair

• As hair is produced, it is keratinized:– middle medulla contains flexible soft keratin– outer cortex and cuticle contain stiff hard

keratin• Hair Color

– Produced by melanocytes at the hair papilla (base)

– Determined by genes

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Sebaceous glands and follicles(oil glands):

• Holocrine exocrine glands that secrete waxy, oil secretion called sebum– Lubricates and protects the hair and skin epidermis– Inhibits bacterial growth

• Sebaceous glands:– associated with most hair follicles (on head and body)

• Sebaceous follicles:– discharge directly onto skin surface– found on face and trunk only– when clogged acne

Sebaceous glands and follicles

Types of Sweat Glands

• Merocrine (eccrine) sweat glands:– more numerous, widely distributed on body surface,

especially on palms and soles (thick skin)– Produce thin sweat for evaporative coolling

• Apocrine sweat glands:– found in armpits, around nipples, and anogential

areas– produce thick sweat

Both are actually merocrine

“Apocrine” Sweat Glands

• Merocrine secretions, not apocrine• Associated with and discharge into hair

follicles in groin, nipples, and axillae(armpits)

• Become active at puberty• Produce sticky, cloudy secretions (thick

sweat) that breaks down, feeds bacteriaand causes odor: pungent, not for cooling

Merocrine Sweat Glands

• Also called eccrine glands:– discharge directly onto skin surface– produce thin sweat– contains water, salts, and organic compounds

• Thin sweat functions– sensible perspiration for evaporative cooling– excretes water and electrolytes– flushes microorganisms and harmful

chemicals from skin

Sweat Glands of the Skin

ApocrineMerocrine

Page 10: Integumentary System (skin) Skin (Integument)facweb.northseattle.edu/jdahms/Fall07/Lectures/Lecture 5...1 Lecture 5 Integumentary System Topics zStructure and function of integument

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Other Integumentary Glands

Specialized sweat glands:• Mammary glands:

– produce milk • Ceruminous glands:

– protect the eardrum– produce cerumen (earwax)

Control of Glands

• Autonomic nervous system:– controls sebaceous and apocrine sweat

glands– works simultaneously over entire body

• Merocrine sweat glands:– are controlled independently– sweating occurs locally (e.g. you can sweat

on just one palm)

Temperature Regulation:Dermal Circulation

Figure 5–8

Dermal circulation• Arteries

– Cutaneous plexus: a network of arteries along the bottom of the reticular layer

– Papillary plexus: capillary network from small arteries in papillary layer

• proximate source of nutrients for epidermal cells• Cells in the s. corneum are too far away to be nourished

through difusion – that’s why they are dead

• Venous plexus:– capillary return deep to the papillary plexus – Bruises usually occur from breakage of these vessels

Temperature Regulation:Perspiration

• Sensible perspiration: – Water excreted by merocrine sweat glands– Cools skin evaporatively

• Insensible perspiration:– Interstitial fluid lost by evaporation through the

stratum corneum– Not so important in cooling but a very

important source of water loss

Water Loss Through Skin

• Dehydration results:– from damage to stratum corneum, e.g., burns

and blisters (insensible perspiration)– from immersion in hypertonic solution, e.g.,

seawater (osmosis)

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Nerves

• Nerve fibers in the skin control:– blood flow through the dermis– gland secretions– sensory receptor (Merkel cells, Meissner’s

corpuscles)

Temperature Regulation: Homeostasis

• Skin plays a major role in controlling body temperature (thermoregulation):

• Body temperature regulation is accomplished by dilation (cooling) and constriction (warming) of dermal vessels– Dilation allows skin to act as a radiator, removes heat

from dermal circulation (radiates heat through skin to environment); constriction helps retain heat

– evaporation of sensible perspiration improves heat removal by

Dermal circulation is the most important factor in body cooling. Sweat makes this cooling more efficient.

Skin: Effects of Aging• Decreased numbers of immune cells• Decreased vitamin D3 production• Decreased melanocyte activity• Decreased function of hair follicles• Slower repair rate• Reduction of elastic fibers (wrinkles)• Skin becomes dry and itchy• Subcutaneous fat layer diminishes (cold intolerance)• Decreased glandular activity (sweat and oil glands)• Epidermal and dermal thinning• Reduced dermal blood supply

Aging and thermoregulation (or “why grandma is always cold”)

1. Epidermis thins, subcutaneous fat decreases, heat escapes more easily

2. Blood supply to dermis is reduced– Causes skin to become cooler– Stimulates thermoreceptors in skin which signal

“coldness,” even in a warm environmentHowever, there is danger of overheating because:

– reduced merocrine sweat gland activity and reduced dermal circulation both lessen ability to lower body temperature effectively

Repair of Localized Injuries to the Skin: Step 1

• Bleeding occurs• Mast cells trigger

inflammatory response

Figure 5–13 (Step 1)

Repair of Localized Injuries to the Skin: Step 2

• A scab stabilizes and protects the area

Figure 5–13 (Step 2)

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The Inflammatory Response

• Germinative cells migrate around the wound

• Macrophages clean the area• Fibroblasts and endothelial cells move in,

producing granulation tissue

Repair of Localized Injuries to the Skin: Step 3

• Fibroblasts produce scar tissue

• Inflammation decreases, clot disintegrates

Figure 5–13 (Step 3)

Repair of Localized Injuries to the Skin: Step 4

• Fibroblasts strengthen scar tissue

• A raised keloid forms

Figure 5–13 (Step 4)

Summary• Structure and function of integument

– Epidermis– Dermis– Hypodermis

• Skin color• Skin cancer and other diseases• Accessory structures of Integument• Temperature regulation• Aging • Skin Injury and regeneration