integrative oncology complementary medicine in the

Dr Jorge Pérez-Calvo SolerDirector of the Centre for Biological Medicine and Integrative

Oncology Unit, Barcelona

INTEGRATIVE ONCOLOGYCOMPLEMENTARY MEDICINE IN THE PREVENTION AND SUPPORT OF THE

ONCOLOGICAL PATIENT

HEALTH WORKING GROUP (ENVI)Public Webinar on Complementary Integrative Medicine

Monday, 11 October 2021, 12.00 - 13.30

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Cancer is responsible for more than 25% oftotal deaths in Europe and is the leadingcause of death between the ages of 45 and65, a number increasing every year (1)

The total cost of cancer was €199billion in Europe in 2018 (5)

1 IN 2 MEN

1 IN 3 WOMEN WILL GET CANCER

Vican5 study : 5 years after cancer :-. 63.5% OF PATIENTS SUFFER FROM SEQUELAE

-. 50% ARE LIMTED IN THEIR PHYSICAL ACTIVITY

I-. 48.7% SUFFERS FROM FATIGUE

(1) EUROSTAT – Statistics Explained. https://ec.europa.eu/eurostat/statistics-explained/index.php?title=Causes_of_death_statistics/es&oldid=505766(2) Howlader N, Noone AM, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2016, National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/csr/1975_2016/, based on November 2018 SEER data submission, posted to the SEER web site, April 2019.(3) International Agency of Research on Cancer. https://gco.iarc.fr/today/home(4) WHO report on cancer: setting priorities, investing wisely and providing care for all. Geneva: World Health Organization; 2020. Licence: CC BY-NC-SA 3.0 IGO.(5) Hofmarcher T., et al. The cost of cancer in Europe 2018; 2020. DOI: https://doi.org/10.1016/j.ejca.2020.01.011(6) « La vie cinq ans après un diagnostic de cancer », INCa, June 2018.

CANCER CASESDiagnosed:4,398,443Deaths:1,955,231

(3)

(4)

(6)

(2)

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2040: projected to increase 70%


Monday, 11 October 2021, 12.00 - 13.30

• CHRONIC INFLAMMATION• OBESITY• ALCOHOL, RED MEAT, REFINED SUGARS• UNAPPROPRIATED FOOD-NUTRITION• HEAVY METALS, ARSENIC,..• ENVIRONMENTAL POLLUTANTS, TOXINS• SEDENTARY LIFESTYLE• SOME ELECTROMAGNETIC RADIATION• TOBACCO• SOME VIRUS• STRONG EMOTIONAL STRESS

MULTIFACTORIAL CANCER CAUSES

IMPROVING LIFESTYLE

COMPLEMENTARYMEDICINES

Greater resilience to diseases and cancer treatment

Better clinical results

Greater Well-being

Longer life expectancy

Decrease in relapses

(7) World Cancer Research Fund / American Institute for Cancer Research.

(7)

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Monday, 11 October 2021, 12.00 - 13.30

CONVENCIONALTREATMENT:• Surgery• Radiation therapy• Chemotherapy• Hormone therapy• Immunotherapy

COMPLEMENTARY THERAPIES• Nutritional medicine and food• Chinese traditional medicine• Acupuncture• Intravenous Vitamin C

Infusions• Ozone therapy• Oncothermia• Psychological stress support• Homeopathy• Yoga y Meditation• Physical exercise• Phytotherapy• Aromatherapy

51% of cancer patients used complementary treatment (8)

(8) Martin R. Keene, Ian M. Heslop, Sabe S. Sabesan, Beverley D. Glass, Complementary and alternative medicine use in cancer: A systematic review, Complementary Therapies in Clinical Practice, Volume 35, 2019, Pages 33-47, ISSN 1744-3881, https://doi.org/10.1016/j.ctcp.2019.01.004.(9) https://www.sjdhospitalbarcelona.org/es/oncologia-integrativa-pediatrica

INTEGRATIVE ONCOLOGY

SANT JOAN DE DÉU HOSPITALComplementary treatment in Children's Oncology

In pediatric oncology, 80% of families with a child with cancer (9)

SCIENTIFIC EVIDENCE

Integrative Oncology seeks to optimize health,biological condition, quality of life, and clinicaloutcomes, throughout the cancer process,supporting and respecting conventional treatment.

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Monday, 11 October 2021, 12.00 - 13.30

In United State of America:

45 National Cancer Institutes (NCI)

Provide services:• 60% centers have integrative medicine doctors• 91% Offer Consultation on nutrition• 73% Offer Acupuncture• 84% Dietary supplements• 67% Herbs• 69% Meditation and Yoga

• In Pediatric Oncology Centers

IMPORTANCE OF INTEGRATIVE ONCOLOGY

(10) Hyeongjun Yun, Lingyun Sun, Jun J. Mao, Growth of Integrative Medicine at Leading Cancer Centers Between 2009 and 2016: A Systematic Analysis of NCI-Designated Comprehensive Cancer Center Websites, JNCI Monographs, Volume 2017, Issue 52, November 2017, lgx004, https://doi.org/10.1093/jncimonographs/lgx004

Excellence care accreditation

Public Hospitals in Europe:• Charité – Universitäts medizin, Berlin• Pediatric Oncologic Center Sant Joan de Déu, Barcelona

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Monday, 11 October 2021, 12.00 - 13.30

CONVENCIONALTREATMENT:• Surgery• Radiation therapy• Chemotherapy• Hormone therapy• Immunotherapy

COMPLEMENTARY THERAPIES• Nutritional medicine and food• Chinese traditional medicine• Acupuncture• Intravenous Vitamin C

Infusions• Ozone therapy• Oncothermia• Psychological stress support• Homeopathy• Yoga y Meditation• Physical exercise• Phytotherapy• Aromatherapy

51% of cancer patients used complementary treatment (8)

(8) Martin R. Keene, Ian M. Heslop, Sabe S. Sabesan, Beverley D. Glass, Complementary and alternative medicine use in cancer: A systematic review, Complementary Therapies in Clinical Practice, Volume 35, 2019, Pages 33-47, ISSN 1744-3881, https://doi.org/10.1016/j.ctcp.2019.01.004.(9) https://www.sjdhospitalbarcelona.org/es/oncologia-integrativa-pediatrica

INTEGRATIVE ONCOLOGY

SANT JOAN DE DÉU HOSPITALComplementary treatment in Children's Oncology

In pediatric oncology, 80% of families with a child with cancer (9)

SCIENTIFIC EVIDENCE

Integrative Oncology seeks to optimize health,biological condition, quality of life, and clinicaloutcomes, throughout the cancer process,supporting and respecting conventional treatment.

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Monday, 11 October 2021, 12.00 - 13.30

NUTRITION IN CANCER

(13) World Cancer Research Fund/American Institute for Cancer Research. Continuous Update Project Expert Report 2018. Judging the evidence. Available in dietandcancerreport.org(14) American Institute for Cancer Research, «AICR, the China Study, and Forks Over Knives», http:// www.aicr.org/ about/ advocacy/ the-china-study.html , 9 January 2015.(15) WHO, Technical Report Series 2003. “Diet, Nutrition and the Prevention of Chronic Diseases”

IMPORTANT SCIENTIFIC EVIDENCE on foods that pose a risk of promoting cancer and foods with the ability to fight it :

WCRF (World Cancer Research Fund)https://www.wcrf.org

AICR (American Institute for Cancer Research)http://www.aicr.org

WHO (World Health Organization) http://www.who.int/es

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(14)

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Monday, 11 October 2021, 12.00 - 13.30

Nutritional medicine can improveadherence to treatment, quality oflife and chances of survival

(13) This material has been reproduced from the World Cancer Research Fund/American Institute for Cancer Research. Diet, Nutrition, Physical Activity and Cancer: a Global Perspective. Continuous Update Project Expert Report 2018. Available at dietandcancerreport.org.

(13)

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Monday, 11 October 2021, 12.00 - 13.30

NUTRITION IN CANCERFoods that pose a risk of promoting cancer and foods with the ability to fight it.


Monday, 11 October 2021, 12.00 - 13.30

(16) Clavo et al., “Ozone therapy as adjuvant for cancer treatment. Is further research Warranted?”.pag.9.Evidence based complementary and alternative medicine. https://doi.org/10.1155/2018/7931849(17) Clavo, et al ,Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects(18) Clavo, et al .Journal of Palliative Medicine. Jan 2021.97-102.http://doi.org/10.1089/jpm.2019.0597(19) Clavo, et al ”OZONOTERAPIA tópica y en el tratamiento de los retardos de cicatrización en pacientes oncológicos” revista de Oncología, volumen uno, pp. 45-46. 1999 8

BERNARDINO CLAVO MD, PHYD (16)Ozone Therapist. Head of the Research Unit at the Hospital Universitario de G. C. Dr. Negrín, Canary Islands Health Service, Spain.

OZONE THERAPY AS AN ONCOLOGICAL ADJUVANT TREATMENTImproves tissues oxygenation . Powerful systemic antioxidant effect.

REFRACTORY ONCOLOGICAL PAIN

SECONDARY TO:• Radiotherapy• Chemotherapy• Endoscopy

REFRACTORY TO MANY TT.• Opioid Treat., • Invasive Techniques in

Chronic Pain Units

IMPROVEMENT: 5 / 6

Worst unimaginable

Pain

NOPain

(18)MODERATE THE TOXIC EFFECT OF CHEMO AND RADIATIONTHERAPY

(17)

HEALING DELAYS IN CANCER PATIENTS WOUNDS (19)

(20) Tirelli U., et al, Oxygen—ozone therapy as support and palliative therapy in 50 cancer patients with fatigue. EUROPEAN REWIEU FOR MEDICAL and farmacological science 2018;22:8030-8033.(21) Waked, I. S., et al . (2013). A Single Blinded Randomized Controlled Clinical Trial on the Efficacy of Ozone Therapy on Breast Cancer-Related Lymphedema. Cancer and Clinical Oncology, 2(2). https://doi.org/10.5539/cco.v2n2p93

(20)FATIGUE and WELLBEING(21)

BREAST CANCER-RELATED LYMPHEDEMA

SINGLE BLINDED RANDOMIZED CONTROLLED CLINICAL TRIALn= 60, randomized with/without O3

All patients were treated with complex physical therapy for lymphedema At 12 weeks Limb volume in both groups.

Improvement was higher in Ozone group: p < 0.05

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More research is needed given its great therapeutic potential


Monday, 11 October 2021, 12.00 - 13.30

OZONE THERAPY AS AN ONCOLOGICAL ADJUVANT TREATMENT

ONCOTHERMIA AS AN ONCOLOGICAL ADJUVANT TREATMENT

(22) Oncothermia Journal https://oncotherm.com/

Reduction of tumors without side effects. Complementary with chemo and radiotherapy, increasing effectiveness.

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ONCOTHERMIA AROUND THE WORLD


Monday, 11 October 2021, 12.00 - 13.30

(22)

(a) Sahinbas H, Baier JE et al. (2006) Retrospective clinical study for advanced brain-gliomas by adjuvant oncothermia (electro-hyperthermia) treatment.(b) Szasz A. Szasz o. Case reports made by Oncothermia. Oncothermia Journal. 2013, 8:47-88(c) Tae Sig Jeung, Sun Young Ma, Jesang Yu, and Sangwook Lim. Cases That Respond to Oncothermia Monotherapy. Conference Papers in Medicine. Volume 2013 (2013), Article ID 392480, 12 pages Szasz A. Szasz o. Case reports made by Oncothermia. Oncothermia Journal. 2013, 8:47-88

Some interesting results in cancer.

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Monday, 11 October 2021, 12.00 - 13.30

Pancreatic cancer at diagnosis

Oncothermia

PANCREAS

REDUCTION IN TUMOR SIZE. STABLE 8 MONTHS.

Lung cancer at diagnosis

Radiotherapy+ Oncothermia

DECREASE IN TUMOR MASS, NORMALIZATION OF TUMOR MARKERS

LUNGGLIOBLASTOMA

glioblastoma multiform at diagnosis. Inoperable

Radio + Quimio therapy + Oncothermia

AFTER FIRST DIAGNOSIS PATIENT SURVIVED 24

MONTHS

(c)(b)(a)

ONCOTHERMIA AS AN ONCOLOGICAL ADJUVANT TREATMENT

SANT JOAN DE DÉU HOSPITAL - PEDIATRIC CANCER CENTER, BARCELONA

TCM AND ACUPUNTUREHigh amount of scientific evidence treatment that helps in different conditions, as pain, nausea and vomiting, xerostomia, hot flushes, fatigue, anxiety, depression

and insomnia

(23) M. Kay Garcia, et al. Systematic Review of Acupuncture in Cancer Care: A Synthesis of the Evidence. J Clin Oncol 31:952-960. © 2013 by American Society of Clinical Oncology. DOI: 10.1200/JCO.2012.43.5818 12

(23)


Monday, 11 October 2021, 12.00 - 13.30

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INTEGRATIVE ONCOLOGY, ACUPUNTURE AND TCM


Monday, 11 October 2021, 12.00 - 13.30

SANT JOAN DE DÉU HOSPITAL - PEDIATRICCANCER CENTER, BARCELONA Excellence care

accreditation

In an attempt to prevent the rising tide of cancer and improve the

quality of life and prognosis of the cancer patient, a framework of

support for complementary medicines / integrative oncology is

required at the level of the European Institutions.

Thanks for your attention

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CONCLUSION

Dr Jorge Pérez-Calvo SolerDirector of the Centre for Biological Medicine and Integrative

Oncology Unit, Barcelona


Monday, 11 October 2021, 12.00 - 13.30

integrative oncology complementary medicine in the

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