institute of living systems

Institute of Living Systems

Neuroscience CenterLaboratory of Stem Cells Research and Regenerative MedicineLaboratory of Experimental OncologyLaboratory of Radiation BiologyLaboratory of Electrophysiology and Modeling of the HeartLaboratory of Plant ElectrophysiologyLaboratory of Biological and Medical ChemistryCenter of Radiophysical Methods in BiomedicineCenter of Mathematical SimulationSPF-vivarium



Neuroscience Center

1. Molecular Neurobiology2. Cellular neurotechnologies3. Extrasynaptic regulation 4. Extracellular matrix of the brain5. Neuroanimats: technologies of neurohybrid systems6. Mathematical modeling: virtual neural networks7. Cellular electrophysiology8. Cognitive neurotechnologies9. Neuron-glial networks

Laboratories:

Mission: Science. Understanding mechanisms and principles of brain functions: from molecular to cognitive levels. The development of neuromorphic intelligenceTechnologies. Optical and electrophysiological monitoring, computer simulations and virtual neural networks, neurointerfaces and neurally controlled robots

Extracellular matrix – extracellular molecular network accompanying synapses and modulating synaptic transmission and plasticity

Perineuronal net in normal conditions and for

schizophrenia

Schi

zoph

reni

a

Npr

mal


Neuroscience Center

Megagrant «Extracellular matrix as a determinant of intercellular communication and a target for therapeutic interventions»Leading scientist: Prof. Alexander Dityatev (Italian Institute of Technologies, Genova, Italy)

Molecular neurobiology

Cellular electrophysiology

“Brain in a chip” – living cells on multielectrode arrays. The development of neuroanimats


Neuroscience Center

Rat or mouse brain (cortex or hippocampus)

Dissociated cells

Multielectrode probe

Growing virtual neurons and neuronal nets in computer simulation

Institute of Living SystemsLaboratory of

Stem cells research and regenerative medicine

Tumor – mesenchimal stem cells interaction investigation by fluorescence bioimaging

Investigation of functional activity of Induced pluripotent stem cells in whole body

Tumor model

RFP labelled mesenchimalStem cells Stem cells

inside the tumor

Development of cells culture system for Bioreactor “Artificial liver” , development Scafolds.

Cell surgery with femtosecond laser system

Lung metastasis with GFP stem cells

630 640 650 660 670 680Em ission wavelength (nm )

0

50

100

150

200

250

Intensity

R O I 1 R O I 2 R O I 3R O I 4 R O I 5

630 640 650 660 670 680Em ission w avelength (nm )

0

50

100

150

200

250

Intensity

R O I 1 R O I 2 R O I 3R O I 4 R O I 5

RFP stem cells inside the tumor

Confocal microscopy (Carl Zeiss, Germany)


Stem cells research and regenerative medicine


Experimental oncology

Fundamental studies of carcinogenesis and molecular mechanisms of cancer response to treatment.

Development of biocompartible contrasting agents for optical methods of cancer diagnostics.Photosensitizers uptake by

cancer cells

Fluorescence whole-body imaging of small animal tumor models

Visualization of heart muscle vasculature using quantum dots

Cancer cells expressing red fluorescent protein


Experimental oncology

Molecular diagnostics of cancer based on targeted delivery of contrasts . Individualization of treatment

Day 6 Day 10 Day 17

scFv-antibodies

Barnase

Barstar

Quantum

dot

Quantum dots-based complexes for targeted labeling of cancer cells

Novel optical methods for screening of antineoplastic drugs

Development of new generation drugs for chemotherapy and photodynamic therapy of cancer

Intravital monitoring of tumor growth by fluorescence imaging method

Study of tumor oxygen state and oxygen-modifying agents for radiation therapy

Study of mechanisms of radiation-induced damage of normal tissues, methods of prophylaxis and treatment

Study of biological effectiveness of hadron therapy (proton and boron-capture therapy) using particle beams from alternative sources)

Hypoxic tumor Oxygenated tumor

Diffuse optical spectroscopy


Radiation biology


Electrophysiology and Modeling of the Heart

Arrhythmology

Investigation of mechanisms of cardiac arrhythmias

Creation of new methods of defibrillation

Computational Cardiology

Creation of software of cardiologist "Virtual Heart“:

3D high-realistic model of main parts of human heart and software for modeling heart activity (both healthy and diseases cases)

Investigation of mechanisms electric signals in plants

Functional role of electrical signals in plants Mathematical simulation of electrogenesis

Study of the effects of physical factors - ionizing radiation and electromagnetic radiation - on higher plants

Development of diagnostic methods of the functional state of higher plants


Plant Electrophysiology

Synthesis of tubulin-binding anticancer molecules acting on colchicine-site

Elaboration of liposomal drug-delivery systems

Construction of fluorescent markers


Biological and Medical Chemistry

Institute of Living Systems Center of Radiophysical Methods in Biomedicine

Laboratories:

«Acoustic methods of diagnostics and treatment monitoring» «Microwaves spectroscopy and radiometry» «Laser methods of living systems research»«Biophotonics»

Development of methods and equipment for diagnostics of biological objects structure and functions, and precision control of biosystems behavior

Mission:

Institute of Living Systems Center of Mathematical Simulation

Laboratories:•«Mathematical problems of biology»•«Complex biostructures»•«Biomedical imaging»

Nonlinear dynamics of living systems and bioinformatics

Research of fractal structures and structural phase transitions in biological and ecological systems

3D stereo-visualization, 3D reconstruction, geometric simulation in biomedicine

institute of living systems

Documents