Instability Dependency of Osteoarthritis Development in a Rabbit Model of Graded Anterior Cruciate Ligament

Transection

by Yuki Tochigi, Tanawat Vaseenon, Anneliese D. Heiner, Douglas C. Fredericks, James A. Martin, M. James Rudert, Stephen L. Hillis, Thomas D. Brown, and Todd

O. McKinley

J Bone Joint Surg AmVolume 93(7):640-647

April 6, 2011

©2011 by The Journal of Bone and Joint Surgery, Inc.

Custom anteroposterior (A-P) loading device for sagittal plane stability measurement, analogous to a clinical so-called drawer test.

Yuki Tochigi et al. J Bone Joint Surg Am 2011;93:640-647

©2011 by The Journal of Bone and Joint Surgery, Inc.

Load-displacement relationships in a stable control knee (left) and an unstable knee after partial ACL transection (right).

Yuki Tochigi et al. J Bone Joint Surg Am 2011;93:640-647

©2011 by The Journal of Bone and Joint Surgery, Inc.

Individual animal data plots for sagittal plane stability measures: anterior drawer stiffness (horizontal axis) and neutral zone length (vertical axis).

Yuki Tochigi et al. J Bone Joint Surg Am 2011;93:640-647

©2011 by The Journal of Bone and Joint Surgery, Inc.

Results of histological evaluation for each individual articular surface.

Yuki Tochigi et al. J Bone Joint Surg Am 2011;93:640-647

©2011 by The Journal of Bone and Joint Surgery, Inc.

Comparisons of global histological findings for individual compartments across treatment groups.

Yuki Tochigi et al. J Bone Joint Surg Am 2011;93:640-647

©2011 by The Journal of Bone and Joint Surgery, Inc.

Correlations of global cartilage degeneration in the medial compartment with instability in the twenty knees that had partial transection of the ACL (including both eight-week and sixteen-week

animals), as assessed by means of anterior drawer test stiffness...

Yuki Tochigi et al. J Bone Joint Surg Am 2011;93:640-647

©2011 by The Journal of Bone and Joint Surgery, Inc.