insight demo
DESCRIPTION
Insight Data Science ProjectTRANSCRIPT
DRUGGED UP?Friederike Schüür
Insight Data Science
“Among 35 to 54 year olds, accidental drug overdoses cause more deaths than motor vehicle crashes and is the leading cause of deaths in seven US states.”
National Safety Council
Di�erent drugs with dif-ferent names may con-tain the same ingredient.
Pseudoephedrine
Actifed, Dixoral, Disophrol, Cardec DM, Robitussin-PE, Sudafed, Cenafed, Actagen, Afrinol, Advil Cold and Sinus, Ryna Liquid ...
Data Sources and Integration
reduced # drugs by > 50%
FDA data
> 3.8 mil. reports> 40 GB JSONs
RxNorm
> 1 mil. drugs> 5 mil. drug relations
Dosage In-formation
Library of Medicine~ 1200 ingredients
MySQL
name normalizationSubsample: 1 or 2 drugs
ingredient matching
1: 44%2: 17%
What should I watch out for?
ID1ID2ID3ID4...
0110...
0000...
0001...
0110...
...
...
...
...
...
Report Side e�ect1
Side e�ect2
Side e�ect3
... Outcome
Naive Bayes Classi�er to predict outcome (serious / not serious) based on side e�ects for drug the user is intersted in.
e.g. Xanax
decreased drug e�ect, constipation, drug intolerance, drug ine�ective, pruritus, panic reaction, nightmare, alopecia
speech disorder, alanine aminotransferase increased, ag-gression, amnesia, hypertension, convulsion, loss of con-sciousness
74% accuracy on held out test set
with sub-sampling to ensure equal class distributions
Each report is the consequence of a person making a decision to submit a report. What drives people to submit reports?
Consumers
Drug ine�ective
Death
NauseaHeadache
Fatigue
0.0 0.1 0.2
% reportsHealth Professionals
% reports
Death
Drug ine�ective
NauseaDyspnoea
Vomiting
0.0 0.1 0.2
Myocardial infarction
Tardive dyskinesia
Cerebrovascular Accident
Extrapyramidal disorder
Pain
Lawyers % reports
0.0 0.1 0.2
W/o contraception, only serious and health professional:
Only not serious cases, only consumer:
All reports:female male
Bootstrap con�dence interval50%
Di�
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My early “career” ...
PhD Cognitive NeuroscienceUniversity College London, UK
Postdoctoral FellowNew York University, NY
