Infectious diseases in literaturePart 2.

Pavlov State Medical University, Department of Infectious diseases

and Epidemiology,St-Petersburg, Russia

Dr. Andrey DyachkovE-mail: cd4@inbox.ru

22.09.2012

In this quiz you have to find out:

1.From which book we took a description of disease?

2.Which infectious disease is described?

Then you can learn a little bit about it

Here comes a description of a disease from a book:

Her chariot is an empty hazelnut,

Made by the joiner squirrel or old grub,

Time out o' mind the fairies' coachmakers.

And in this state she 'gallops night by night

Through lovers' brains, and then they dream of love;

O'er courtiers' knees, that dream on cursies straight;

O'er lawyers' fingers, who straight dream on fees;

O'er ladies' lips, who straight on kisses dream,

Which oft the angry Mab with blisters plagues,

Because their breaths with sweetmeats tainted are.

This hint can help you to figure out a name of a book.

William Shakespeare «Romeo and Juliet» William Shakespeare (26 April 1564

(baptised) – 23 April 1616) was an English poet and playwright, widely regarded as the greatest writer in the English language and the world's pre-eminent dramatist

Between 1585 and 1592, he began a successful career in London as an actor, writer, and part owner of a playing company called the Lord Chamberlain's Men

The famous Globe Theatre was built in 1599 by Shakespeare's playing company and closed in 1642.

A modern reconstruction of the Globe, named "Shakespeare's Globe", opened in 1997 approximately 750 feet from the site of the original theatre.

In Romeo and Juilet plagues on lips was related to sweets but there were many other theories of disease nature and development

Description of disease is found in Hyppocrates works and word “herpes” is a Greek word that means “to creep or crawl”.

Roman times, the emperor Tiberius tried to stop an outbreak of mouth herpes by prohibiting kissing at public events and ceremonies.

First modern publication of the link between genital organs and Herpes was published in 1736 by John Astruc, doctor for King Louis XIV.

History of Herpes Simplex VirusJean Baptiste Emile Vidal, a French dermatologist, in 1893 reported evidence that Herpes was infectious.

In Germany W. Gruter in 1912 showed that fluid from human HSV lesions can cause keratitis in rabbits and then could be transmitted serially from rabbit to rabbit. It is to him that the virology community gives credit for the isolation of HSV.

In the 1930s, one of the milestones of HSV biology was the observation made by Andrews and Carmichael that recurrent infections occurred only in adults who carried neutralizing antibodies – an occurrence in sharp contrast to the behaviour of other known infectious agents at that time.

It was Schneweis and Nahmias who proposed that two different types of HSV caused these infections – one for involvement of the mouth and the other of the genital tract.

History of Herpes Simplex Virus

First, in 1938, Doerr stated that HSV infection in man resulted from the endogenous production and were not caused by exogenous infection.

Dr Gertrude Elion, one of the leading figures in the discovery of first selective inhibitor of HSV aciclovir (1977).

Gertrude B. Elion (1918 - 1995) and George H. Hitchings (1905 — 1998) had been working together since 1945 and in 1988 won the Noble Prize for their work on the treatment of disease and organ transplantation.

Later sexual revolution made a herpes a topic of piblic discussions

HSV can cause Labial and genital herpes but

cuold have atypical localisation at any site on skin

Keratoconjunctivitis

Meningitis

Encephalitis

Esophagitis

In HIV-infected patients HSV can cause long healing ulcers (more then 1 month) — picture on the right

HSV encephalitis was first described in 1940s. Disease could be seen during primary infection and in patients with reccurent labial and genital herpes.

Temporal lobes involment with aphasia and other focal neurological symptoms are typical. CSF examination usually shows mononuclear pleocytosis (please note that in early stage could be neutrophil) with

normal sugar and moderate protein increase.

Please visit our Facebook group «Infectious diseases for doctors» to find photous and new clinical cases from infectious diseases hospital.http://www.facebook.com/groups/414509858598674/

Botkin's infectious diseases hospital was foundin St-Petersburg in 1882