INDORAMIN IMPROVES BL.OOD ROW IN DIGITAL. VASCUL.AR DISEASE

I 5 patients with digital artery disease in association with trophic changes in the digits had s ignificantly fewer attacks of Raynaud's phenomenon and related episodic phenomena when treated with indoramin. Digital blood flow was improved and there was Ie..<;s

discomfort in the hands, Indoramin or placebo were given double.blind and crossed over after 3 weeks. The dosage was 90mg PO daily in 3 divided doses. There were fewer attacks of digital colour change with indoramin and the mean daily degree of discomfort was reduced compared with placebo. Very few sideetTects occurred. RObson. P.~! aL British Journal of Clinical Pharmacology 6,. 88 (Jul 191&)

. .. But it Does Not Help Bed Wetting Children Tricyclic drugs, especially imipramine have significant anti-enuret ic action in children. An attempt to mimic the known (l­adrenolytic action of im ipramine by treating 14 enuretic school children with a competitive a-adrenoceptor blocking agent, indoramin, had no significant effect on night bed-wetting freq uency. The children took either 10 or 20mg of indo ram in 30 minutes before bedtime for three 2-week periods. The mean numberofdry nights in each session was 3.75 in the control group,

3.30 with placebo, 4.03 with tOmg indoramin and 3.61 with 20mg indoramin. The 4 children with small bladder capacity fared no better than those with larger capacities. The study did not support the notion thai tricyctic drugs control enuresis principally through an effect on autonomic transmitters. An informal study to sce whether bladder oontrol was by a combination of actions, in which children received Single evening doses of propantheline bromide I Smg and indoramin IOmg, failed to show any benefit after 7 night.<;. Sltarfer. o. el al.: D~velopm~ ntal Medicine and Child Neurology 20: r 83 (Apr 1978)

INPHARMA 22nd July. 1978 p9