INDONESIAN COUNTRY REPORT INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINEON TRADITIONAL MEDICINE

M Hanafi Nina A Zorni Fadia NurbaitiM Hanafi Nina A Zorni Fadia Nurbaiti

INDONESIA

TRADITIONAL MEDICINESINTRODUCTIONINTRODUCTION

bull The traditional herbal system of medicine has been used since ancient times

bull Most of the developing countries and in particular those situated in the tropical belt such as Indonesia constitute richest store house of medicinal plants

bull Only a few of these countries have been able to organize proper system of research and development for exploitation conservation or industrial use of these plants

bull The indiscriminate export and exploitation by private traders ofvaluable raw materials also creates ecological imbalance

bull Indonesian government has in view of its importance identified medicinal plants as a priority area of the countryrsquos program

Indonesia is known as a country with a megadiversity of biological species

as well as the megacenter for world biodiversity

Indonesia possessIndonesia possess1010 of worldrsquos of worldrsquos flowering plant speciesflowering plant species12 of worldrsquos mammal species12 of worldrsquos mammal species16 of worldrsquos reptile and amphibian species16 of worldrsquos reptile and amphibian species17 of worldrsquos bird species17 of worldrsquos bird species25 of worldrsquos fish species25 of worldrsquos fish species15 of worldrsquos insect species15 of worldrsquos insect species

Indonesia forest and marine content a huge of biodiversity

Almost 30000 plants of herbal medicinal Almost 30000 plants of herbal medicinal ApprAppr 7000 species known and have been 7000 species known and have beenused for medical purposesused for medical purposesAbout 250 species used in the traditionalAbout 250 species used in the traditionalherbal medicine herbal medicine JamuJamu industries industriesIn 2003 a total of 9737 items of herbal medicines has In 2003 a total of 9737 items of herbal medicines has been registered which include 1093 items imported been registered which include 1093 items imported productsproducts

Trend of Herbal Medicines in Trend of Herbal Medicines in IndonesiaIndonesia

YearYear Modern Modern MedicinesMedicines

US $ (billion)US $ (billion)

Herbal Herbal MedicinesMedicines

US $ (billionUS $ (billion

Contribution Contribution Herbal MedHerbal Med

20032003 170170 2020 105105

20052005 213213 2929 120120

2010 2010 EstEst

373373 7272 160160

Source BPPT 2005

Indonesian herbal medicines are used Indonesian herbal medicines are used based on empirical practice diseases based on empirical practice diseases preventive (489) health promotion (2247 preventive (489) health promotion (2247 ) diseases curative (2178) and the rests ) diseases curative (2178) and the rests are for cosmeticsare for cosmetics

bullbullAccording to Indonesian Medical Association According to Indonesian Medical Association (IDI) statements herbal medicines will be (IDI) statements herbal medicines will be

accepted formally by the conventional (Western) accepted formally by the conventional (Western) medical doctors if its safety and efficacy has medical doctors if its safety and efficacy has

been proved scientifically (current trend been proved scientifically (current trend application especially for degenerative application especially for degenerative

diseases certain viral infection and cancer)diseases certain viral infection and cancer)

The categories based on their processing The categories based on their processing developmentdevelopment

Herbal product falls into traditional medicinefalls into traditional medicine((jamujamu) ) when the when the process is simple and toxicity process is simple and toxicity evaluation is recommended (not compulsory)evaluation is recommended (not compulsory) Standardized extract preparationStandardized extract preparation when the when the process is more complexprocess is more complex than than jamujamu has been has been controlled chemically and has a preclinical controlled chemically and has a preclinical (toxicology pharmacology) evaluation(toxicology pharmacology) evaluation PhytopharmaceuticalPhytopharmaceutical when it has a when it has a complex complex process preclinical and clinical evaluation for process preclinical and clinical evaluation for safety and efficacy insurance is a mustsafety and efficacy insurance is a must

PHYTOPHARMACYPHYTOPHARMACY

TRADITIONAL MEDICINESTRADITIONAL MEDICINESWHICH HAVE BEEN PROVENWHICH HAVE BEEN PROVEN

SAFE EFECTIVE SAFE EFECTIVE QUALITY QUALITY

STANDARDIZEDSTANDARDIZED

MoH Decree No 760 1992

PHYTOPHARMACYPHYTOPHARMACY

TENSIGARDTENSIGARD

PHYTODIARPHYTODIAR

RHEUMANEERRHEUMANEER

X GRAX GRA

STIMUNOSTIMUNO

TRADITIONAL MEDICINESTRADITIONAL MEDICINESMoHMoH Decree 246MenkesPerV1990Decree 246MenkesPerV1990

PROHIBITED PROHIBITED

MIXEDCOMPOUNDED MIXEDCOMPOUNDED WITH MODERN MEDICINESWITH MODERN MEDICINES

Research and Systematization of Research and Systematization of Indonesian Traditional MedicinesIndonesian Traditional Medicines

clubsclubs Modern research on Indonesian herbal medicines in research Modern research on Indonesian herbal medicines in research institutions universities and industriesinstitutions universities and industries

clubsclubs

clubsclubs PublicationsPublicationsclubsclubs All of these efforts are All of these efforts are dedicated to the development of dedicated to the development of

Indonesian medicinal plantsIndonesian medicinal plants to be able to compete globallyto be able to compete globallyclubsclubs International requirements such as on International requirements such as on GMP GAP GLP ICHGMP GAP GLP ICH--

GCPGCP (The International Conference on Harmonization(The International Conference on Harmonization--Good Good Clinical Practice) Clinical Practice) Research Guidelines for Evaluating the Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines HACCPSafety and Efficacy of Herbal Medicines HACCP etc should etc should be followed be followed

bull Origin bull Distribution bull Resources bull Therapeutic usagebull Process bull Quality bull Safety bull Efficacy

Nine medicinal plants of first priority for Nine medicinal plants of first priority for phytopharmaceuticals phytopharmaceuticals

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

11

PsidiumPsidium guajavaguajava

Leaves Leaves immunomodulatorimmunomodulator

AstringentAstringentTraditional Most Traditional Most

famous preparation famous preparation for dengue treatmentfor dengue treatment

22

MorindaMorinda citrifoliacitrifolia

Fruit AntiFruit Anti--hypertensionhypertension

Leaves Leaves AntidiabeticAntidiabetic

MorindoneMorindone

O

O

OH

OH

O

O

OH

HO

OGlc(1-6)-Glc

Morindin

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

33

SizygiumSizygium polyanthumpolyanthum

Leaves Leaves AntidiabeticAntidiabetic

44

GuazumaGuazuma ulmifoliaulmifolia

Leaves Leaves AntiobesityAntiobesity

CatechinCatechin and and FriedelinFriedelin

55

ZingiberZingiber officinaleofficinale

Rhizomes Rhizomes CarminativeCarminativeStomachicStomachicStimulantsStimulants

GingerolGingerol

(CH2)nCH3

MeO

HO

O OH

OH

OH

HO O

OH

OH

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

66

Curcuma Curcuma domesticadomestica

Rhizomes Rhizomes AntilipedemicAntilipedemicAntiAnti--bacteria bacteria cholagogumcholagogum

ImmunoImmuno--stimulantsstimulants

CurcuminoidCurcuminoid

77

Curcuma Curcuma xanthorrhizaxanthorrhiza

Rhizomes Rhizomes HepatoprotectorHepatoprotector

CholereticCholeretic antiinflammationantiinflammation

CurcuminoidCurcuminoid

XanthorhizolXanthorhizol

88

AndrographisAndrographis paniculatapaniculata

Leaves Leaves Antipyretic antiAntipyretic anti--

ulcer ulcer antidiabeticantidiabetic

AndrographolideAndrographolide (1) (1) Neoandrographolide(2)Neoandrographolide(2)

O O

OMe

OH

MeO

HO

O

OH

O

OH

OH

(1)

OO O

O

HO

HO OH

OH

(2)

OH

O O

OMe

OH

MeO

HO

NoNo PlantPlant Medicinal Medicinal UsesUses BioBio--markermarker

99

CentellaCentella asiaticaasiatica

Aerial partAerial partVasodilatorVasodilator

ImmunoImmuno--stimulantsstimulants

AsiaticosideAsiaticoside and and MadecasolMadecasol

O

OH

HO

HO

O

O

HO

OH

HO

O

O

HO OH

OH

O

O

OH

OHHO

IntelectualIntelectual Property Property Right Protection Right Protection

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

Indonesia is known as a country with a megadiversity of biological species

as well as the megacenter for world biodiversity

Indonesia possessIndonesia possess1010 of worldrsquos of worldrsquos flowering plant speciesflowering plant species12 of worldrsquos mammal species12 of worldrsquos mammal species16 of worldrsquos reptile and amphibian species16 of worldrsquos reptile and amphibian species17 of worldrsquos bird species17 of worldrsquos bird species25 of worldrsquos fish species25 of worldrsquos fish species15 of worldrsquos insect species15 of worldrsquos insect species

Indonesia forest and marine content a huge of biodiversity

Almost 30000 plants of herbal medicinal Almost 30000 plants of herbal medicinal ApprAppr 7000 species known and have been 7000 species known and have beenused for medical purposesused for medical purposesAbout 250 species used in the traditionalAbout 250 species used in the traditionalherbal medicine herbal medicine JamuJamu industries industriesIn 2003 a total of 9737 items of herbal medicines has In 2003 a total of 9737 items of herbal medicines has been registered which include 1093 items imported been registered which include 1093 items imported productsproducts

Trend of Herbal Medicines in Trend of Herbal Medicines in IndonesiaIndonesia

YearYear Modern Modern MedicinesMedicines

US $ (billion)US $ (billion)

Herbal Herbal MedicinesMedicines

US $ (billionUS $ (billion

Contribution Contribution Herbal MedHerbal Med

20032003 170170 2020 105105

20052005 213213 2929 120120

2010 2010 EstEst

373373 7272 160160

Source BPPT 2005

Indonesian herbal medicines are used Indonesian herbal medicines are used based on empirical practice diseases based on empirical practice diseases preventive (489) health promotion (2247 preventive (489) health promotion (2247 ) diseases curative (2178) and the rests ) diseases curative (2178) and the rests are for cosmeticsare for cosmetics

bullbullAccording to Indonesian Medical Association According to Indonesian Medical Association (IDI) statements herbal medicines will be (IDI) statements herbal medicines will be

accepted formally by the conventional (Western) accepted formally by the conventional (Western) medical doctors if its safety and efficacy has medical doctors if its safety and efficacy has

been proved scientifically (current trend been proved scientifically (current trend application especially for degenerative application especially for degenerative

diseases certain viral infection and cancer)diseases certain viral infection and cancer)

The categories based on their processing The categories based on their processing developmentdevelopment

Herbal product falls into traditional medicinefalls into traditional medicine((jamujamu) ) when the when the process is simple and toxicity process is simple and toxicity evaluation is recommended (not compulsory)evaluation is recommended (not compulsory) Standardized extract preparationStandardized extract preparation when the when the process is more complexprocess is more complex than than jamujamu has been has been controlled chemically and has a preclinical controlled chemically and has a preclinical (toxicology pharmacology) evaluation(toxicology pharmacology) evaluation PhytopharmaceuticalPhytopharmaceutical when it has a when it has a complex complex process preclinical and clinical evaluation for process preclinical and clinical evaluation for safety and efficacy insurance is a mustsafety and efficacy insurance is a must

PHYTOPHARMACYPHYTOPHARMACY

TRADITIONAL MEDICINESTRADITIONAL MEDICINESWHICH HAVE BEEN PROVENWHICH HAVE BEEN PROVEN

SAFE EFECTIVE SAFE EFECTIVE QUALITY QUALITY

STANDARDIZEDSTANDARDIZED

MoH Decree No 760 1992

PHYTOPHARMACYPHYTOPHARMACY

TENSIGARDTENSIGARD

PHYTODIARPHYTODIAR

RHEUMANEERRHEUMANEER

X GRAX GRA

STIMUNOSTIMUNO

TRADITIONAL MEDICINESTRADITIONAL MEDICINESMoHMoH Decree 246MenkesPerV1990Decree 246MenkesPerV1990

PROHIBITED PROHIBITED

MIXEDCOMPOUNDED MIXEDCOMPOUNDED WITH MODERN MEDICINESWITH MODERN MEDICINES

Research and Systematization of Research and Systematization of Indonesian Traditional MedicinesIndonesian Traditional Medicines

clubsclubs Modern research on Indonesian herbal medicines in research Modern research on Indonesian herbal medicines in research institutions universities and industriesinstitutions universities and industries

clubsclubs

clubsclubs PublicationsPublicationsclubsclubs All of these efforts are All of these efforts are dedicated to the development of dedicated to the development of

Indonesian medicinal plantsIndonesian medicinal plants to be able to compete globallyto be able to compete globallyclubsclubs International requirements such as on International requirements such as on GMP GAP GLP ICHGMP GAP GLP ICH--

GCPGCP (The International Conference on Harmonization(The International Conference on Harmonization--Good Good Clinical Practice) Clinical Practice) Research Guidelines for Evaluating the Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines HACCPSafety and Efficacy of Herbal Medicines HACCP etc should etc should be followed be followed

bull Origin bull Distribution bull Resources bull Therapeutic usagebull Process bull Quality bull Safety bull Efficacy

Nine medicinal plants of first priority for Nine medicinal plants of first priority for phytopharmaceuticals phytopharmaceuticals

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

11

PsidiumPsidium guajavaguajava

Leaves Leaves immunomodulatorimmunomodulator

AstringentAstringentTraditional Most Traditional Most

famous preparation famous preparation for dengue treatmentfor dengue treatment

22

MorindaMorinda citrifoliacitrifolia

Fruit AntiFruit Anti--hypertensionhypertension

Leaves Leaves AntidiabeticAntidiabetic

MorindoneMorindone

O

O

OH

OH

O

O

OH

HO

OGlc(1-6)-Glc

Morindin

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

33

SizygiumSizygium polyanthumpolyanthum

Leaves Leaves AntidiabeticAntidiabetic

44

GuazumaGuazuma ulmifoliaulmifolia

Leaves Leaves AntiobesityAntiobesity

CatechinCatechin and and FriedelinFriedelin

55

ZingiberZingiber officinaleofficinale

Rhizomes Rhizomes CarminativeCarminativeStomachicStomachicStimulantsStimulants

GingerolGingerol

(CH2)nCH3

MeO

HO

O OH

OH

OH

HO O

OH

OH

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

66

Curcuma Curcuma domesticadomestica

Rhizomes Rhizomes AntilipedemicAntilipedemicAntiAnti--bacteria bacteria cholagogumcholagogum

ImmunoImmuno--stimulantsstimulants

CurcuminoidCurcuminoid

77

Curcuma Curcuma xanthorrhizaxanthorrhiza

Rhizomes Rhizomes HepatoprotectorHepatoprotector

CholereticCholeretic antiinflammationantiinflammation

CurcuminoidCurcuminoid

XanthorhizolXanthorhizol

88

AndrographisAndrographis paniculatapaniculata

Leaves Leaves Antipyretic antiAntipyretic anti--

ulcer ulcer antidiabeticantidiabetic

AndrographolideAndrographolide (1) (1) Neoandrographolide(2)Neoandrographolide(2)

O O

OMe

OH

MeO

HO

O

OH

O

OH

OH

(1)

OO O

O

HO

HO OH

OH

(2)

OH

O O

OMe

OH

MeO

HO

NoNo PlantPlant Medicinal Medicinal UsesUses BioBio--markermarker

99

CentellaCentella asiaticaasiatica

Aerial partAerial partVasodilatorVasodilator

ImmunoImmuno--stimulantsstimulants

AsiaticosideAsiaticoside and and MadecasolMadecasol

O

OH

HO

HO

O

O

HO

OH

HO

O

O

HO OH

OH

O

O

OH

OHHO

IntelectualIntelectual Property Property Right Protection Right Protection

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

Indonesia forest and marine content a huge of biodiversity

Almost 30000 plants of herbal medicinal Almost 30000 plants of herbal medicinal ApprAppr 7000 species known and have been 7000 species known and have beenused for medical purposesused for medical purposesAbout 250 species used in the traditionalAbout 250 species used in the traditionalherbal medicine herbal medicine JamuJamu industries industriesIn 2003 a total of 9737 items of herbal medicines has In 2003 a total of 9737 items of herbal medicines has been registered which include 1093 items imported been registered which include 1093 items imported productsproducts

Trend of Herbal Medicines in Trend of Herbal Medicines in IndonesiaIndonesia

YearYear Modern Modern MedicinesMedicines

US $ (billion)US $ (billion)

Herbal Herbal MedicinesMedicines

US $ (billionUS $ (billion

Contribution Contribution Herbal MedHerbal Med

20032003 170170 2020 105105

20052005 213213 2929 120120

2010 2010 EstEst

373373 7272 160160

Source BPPT 2005

Indonesian herbal medicines are used Indonesian herbal medicines are used based on empirical practice diseases based on empirical practice diseases preventive (489) health promotion (2247 preventive (489) health promotion (2247 ) diseases curative (2178) and the rests ) diseases curative (2178) and the rests are for cosmeticsare for cosmetics

bullbullAccording to Indonesian Medical Association According to Indonesian Medical Association (IDI) statements herbal medicines will be (IDI) statements herbal medicines will be

accepted formally by the conventional (Western) accepted formally by the conventional (Western) medical doctors if its safety and efficacy has medical doctors if its safety and efficacy has

been proved scientifically (current trend been proved scientifically (current trend application especially for degenerative application especially for degenerative

diseases certain viral infection and cancer)diseases certain viral infection and cancer)

The categories based on their processing The categories based on their processing developmentdevelopment

Herbal product falls into traditional medicinefalls into traditional medicine((jamujamu) ) when the when the process is simple and toxicity process is simple and toxicity evaluation is recommended (not compulsory)evaluation is recommended (not compulsory) Standardized extract preparationStandardized extract preparation when the when the process is more complexprocess is more complex than than jamujamu has been has been controlled chemically and has a preclinical controlled chemically and has a preclinical (toxicology pharmacology) evaluation(toxicology pharmacology) evaluation PhytopharmaceuticalPhytopharmaceutical when it has a when it has a complex complex process preclinical and clinical evaluation for process preclinical and clinical evaluation for safety and efficacy insurance is a mustsafety and efficacy insurance is a must

PHYTOPHARMACYPHYTOPHARMACY

TRADITIONAL MEDICINESTRADITIONAL MEDICINESWHICH HAVE BEEN PROVENWHICH HAVE BEEN PROVEN

SAFE EFECTIVE SAFE EFECTIVE QUALITY QUALITY

STANDARDIZEDSTANDARDIZED

MoH Decree No 760 1992

PHYTOPHARMACYPHYTOPHARMACY

TENSIGARDTENSIGARD

PHYTODIARPHYTODIAR

RHEUMANEERRHEUMANEER

X GRAX GRA

STIMUNOSTIMUNO

TRADITIONAL MEDICINESTRADITIONAL MEDICINESMoHMoH Decree 246MenkesPerV1990Decree 246MenkesPerV1990

PROHIBITED PROHIBITED

MIXEDCOMPOUNDED MIXEDCOMPOUNDED WITH MODERN MEDICINESWITH MODERN MEDICINES

Research and Systematization of Research and Systematization of Indonesian Traditional MedicinesIndonesian Traditional Medicines

clubsclubs Modern research on Indonesian herbal medicines in research Modern research on Indonesian herbal medicines in research institutions universities and industriesinstitutions universities and industries

clubsclubs

clubsclubs PublicationsPublicationsclubsclubs All of these efforts are All of these efforts are dedicated to the development of dedicated to the development of

Indonesian medicinal plantsIndonesian medicinal plants to be able to compete globallyto be able to compete globallyclubsclubs International requirements such as on International requirements such as on GMP GAP GLP ICHGMP GAP GLP ICH--

GCPGCP (The International Conference on Harmonization(The International Conference on Harmonization--Good Good Clinical Practice) Clinical Practice) Research Guidelines for Evaluating the Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines HACCPSafety and Efficacy of Herbal Medicines HACCP etc should etc should be followed be followed

bull Origin bull Distribution bull Resources bull Therapeutic usagebull Process bull Quality bull Safety bull Efficacy

Nine medicinal plants of first priority for Nine medicinal plants of first priority for phytopharmaceuticals phytopharmaceuticals

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

11

PsidiumPsidium guajavaguajava

Leaves Leaves immunomodulatorimmunomodulator

AstringentAstringentTraditional Most Traditional Most

famous preparation famous preparation for dengue treatmentfor dengue treatment

22

MorindaMorinda citrifoliacitrifolia

Fruit AntiFruit Anti--hypertensionhypertension

Leaves Leaves AntidiabeticAntidiabetic

MorindoneMorindone

O

O

OH

OH

O

O

OH

HO

OGlc(1-6)-Glc

Morindin

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

33

SizygiumSizygium polyanthumpolyanthum

Leaves Leaves AntidiabeticAntidiabetic

44

GuazumaGuazuma ulmifoliaulmifolia

Leaves Leaves AntiobesityAntiobesity

CatechinCatechin and and FriedelinFriedelin

55

ZingiberZingiber officinaleofficinale

Rhizomes Rhizomes CarminativeCarminativeStomachicStomachicStimulantsStimulants

GingerolGingerol

(CH2)nCH3

MeO

HO

O OH

OH

OH

HO O

OH

OH

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

66

Curcuma Curcuma domesticadomestica

Rhizomes Rhizomes AntilipedemicAntilipedemicAntiAnti--bacteria bacteria cholagogumcholagogum

ImmunoImmuno--stimulantsstimulants

CurcuminoidCurcuminoid

77

Curcuma Curcuma xanthorrhizaxanthorrhiza

Rhizomes Rhizomes HepatoprotectorHepatoprotector

CholereticCholeretic antiinflammationantiinflammation

CurcuminoidCurcuminoid

XanthorhizolXanthorhizol

88

AndrographisAndrographis paniculatapaniculata

Leaves Leaves Antipyretic antiAntipyretic anti--

ulcer ulcer antidiabeticantidiabetic

AndrographolideAndrographolide (1) (1) Neoandrographolide(2)Neoandrographolide(2)

O O

OMe

OH

MeO

HO

O

OH

O

OH

OH

(1)

OO O

O

HO

HO OH

OH

(2)

OH

O O

OMe

OH

MeO

HO

NoNo PlantPlant Medicinal Medicinal UsesUses BioBio--markermarker

99

CentellaCentella asiaticaasiatica

Aerial partAerial partVasodilatorVasodilator

ImmunoImmuno--stimulantsstimulants

AsiaticosideAsiaticoside and and MadecasolMadecasol

O

OH

HO

HO

O

O

HO

OH

HO

O

O

HO OH

OH

O

O

OH

OHHO

IntelectualIntelectual Property Property Right Protection Right Protection

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

Trend of Herbal Medicines in Trend of Herbal Medicines in IndonesiaIndonesia

YearYear Modern Modern MedicinesMedicines

US $ (billion)US $ (billion)

Herbal Herbal MedicinesMedicines

US $ (billionUS $ (billion

Contribution Contribution Herbal MedHerbal Med

20032003 170170 2020 105105

20052005 213213 2929 120120

2010 2010 EstEst

373373 7272 160160

Source BPPT 2005

Indonesian herbal medicines are used Indonesian herbal medicines are used based on empirical practice diseases based on empirical practice diseases preventive (489) health promotion (2247 preventive (489) health promotion (2247 ) diseases curative (2178) and the rests ) diseases curative (2178) and the rests are for cosmeticsare for cosmetics

bullbullAccording to Indonesian Medical Association According to Indonesian Medical Association (IDI) statements herbal medicines will be (IDI) statements herbal medicines will be

accepted formally by the conventional (Western) accepted formally by the conventional (Western) medical doctors if its safety and efficacy has medical doctors if its safety and efficacy has

been proved scientifically (current trend been proved scientifically (current trend application especially for degenerative application especially for degenerative

diseases certain viral infection and cancer)diseases certain viral infection and cancer)

The categories based on their processing The categories based on their processing developmentdevelopment

Herbal product falls into traditional medicinefalls into traditional medicine((jamujamu) ) when the when the process is simple and toxicity process is simple and toxicity evaluation is recommended (not compulsory)evaluation is recommended (not compulsory) Standardized extract preparationStandardized extract preparation when the when the process is more complexprocess is more complex than than jamujamu has been has been controlled chemically and has a preclinical controlled chemically and has a preclinical (toxicology pharmacology) evaluation(toxicology pharmacology) evaluation PhytopharmaceuticalPhytopharmaceutical when it has a when it has a complex complex process preclinical and clinical evaluation for process preclinical and clinical evaluation for safety and efficacy insurance is a mustsafety and efficacy insurance is a must

PHYTOPHARMACYPHYTOPHARMACY

TRADITIONAL MEDICINESTRADITIONAL MEDICINESWHICH HAVE BEEN PROVENWHICH HAVE BEEN PROVEN

SAFE EFECTIVE SAFE EFECTIVE QUALITY QUALITY

STANDARDIZEDSTANDARDIZED

MoH Decree No 760 1992

PHYTOPHARMACYPHYTOPHARMACY

TENSIGARDTENSIGARD

PHYTODIARPHYTODIAR

RHEUMANEERRHEUMANEER

X GRAX GRA

STIMUNOSTIMUNO

TRADITIONAL MEDICINESTRADITIONAL MEDICINESMoHMoH Decree 246MenkesPerV1990Decree 246MenkesPerV1990

PROHIBITED PROHIBITED

MIXEDCOMPOUNDED MIXEDCOMPOUNDED WITH MODERN MEDICINESWITH MODERN MEDICINES

Research and Systematization of Research and Systematization of Indonesian Traditional MedicinesIndonesian Traditional Medicines

clubsclubs Modern research on Indonesian herbal medicines in research Modern research on Indonesian herbal medicines in research institutions universities and industriesinstitutions universities and industries

clubsclubs

clubsclubs PublicationsPublicationsclubsclubs All of these efforts are All of these efforts are dedicated to the development of dedicated to the development of

Indonesian medicinal plantsIndonesian medicinal plants to be able to compete globallyto be able to compete globallyclubsclubs International requirements such as on International requirements such as on GMP GAP GLP ICHGMP GAP GLP ICH--

GCPGCP (The International Conference on Harmonization(The International Conference on Harmonization--Good Good Clinical Practice) Clinical Practice) Research Guidelines for Evaluating the Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines HACCPSafety and Efficacy of Herbal Medicines HACCP etc should etc should be followed be followed

bull Origin bull Distribution bull Resources bull Therapeutic usagebull Process bull Quality bull Safety bull Efficacy

Nine medicinal plants of first priority for Nine medicinal plants of first priority for phytopharmaceuticals phytopharmaceuticals

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

11

PsidiumPsidium guajavaguajava

Leaves Leaves immunomodulatorimmunomodulator

AstringentAstringentTraditional Most Traditional Most

famous preparation famous preparation for dengue treatmentfor dengue treatment

22

MorindaMorinda citrifoliacitrifolia

Fruit AntiFruit Anti--hypertensionhypertension

Leaves Leaves AntidiabeticAntidiabetic

MorindoneMorindone

O

O

OH

OH

O

O

OH

HO

OGlc(1-6)-Glc

Morindin

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

33

SizygiumSizygium polyanthumpolyanthum

Leaves Leaves AntidiabeticAntidiabetic

44

GuazumaGuazuma ulmifoliaulmifolia

Leaves Leaves AntiobesityAntiobesity

CatechinCatechin and and FriedelinFriedelin

55

ZingiberZingiber officinaleofficinale

Rhizomes Rhizomes CarminativeCarminativeStomachicStomachicStimulantsStimulants

GingerolGingerol

(CH2)nCH3

MeO

HO

O OH

OH

OH

HO O

OH

OH

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

66

Curcuma Curcuma domesticadomestica

Rhizomes Rhizomes AntilipedemicAntilipedemicAntiAnti--bacteria bacteria cholagogumcholagogum

ImmunoImmuno--stimulantsstimulants

CurcuminoidCurcuminoid

77

Curcuma Curcuma xanthorrhizaxanthorrhiza

Rhizomes Rhizomes HepatoprotectorHepatoprotector

CholereticCholeretic antiinflammationantiinflammation

CurcuminoidCurcuminoid

XanthorhizolXanthorhizol

88

AndrographisAndrographis paniculatapaniculata

Leaves Leaves Antipyretic antiAntipyretic anti--

ulcer ulcer antidiabeticantidiabetic

AndrographolideAndrographolide (1) (1) Neoandrographolide(2)Neoandrographolide(2)

O O

OMe

OH

MeO

HO

O

OH

O

OH

OH

(1)

OO O

O

HO

HO OH

OH

(2)

OH

O O

OMe

OH

MeO

HO

NoNo PlantPlant Medicinal Medicinal UsesUses BioBio--markermarker

99

CentellaCentella asiaticaasiatica

Aerial partAerial partVasodilatorVasodilator

ImmunoImmuno--stimulantsstimulants

AsiaticosideAsiaticoside and and MadecasolMadecasol

O

OH

HO

HO

O

O

HO

OH

HO

O

O

HO OH

OH

O

O

OH

OHHO

IntelectualIntelectual Property Property Right Protection Right Protection

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

Indonesian herbal medicines are used Indonesian herbal medicines are used based on empirical practice diseases based on empirical practice diseases preventive (489) health promotion (2247 preventive (489) health promotion (2247 ) diseases curative (2178) and the rests ) diseases curative (2178) and the rests are for cosmeticsare for cosmetics

bullbullAccording to Indonesian Medical Association According to Indonesian Medical Association (IDI) statements herbal medicines will be (IDI) statements herbal medicines will be

accepted formally by the conventional (Western) accepted formally by the conventional (Western) medical doctors if its safety and efficacy has medical doctors if its safety and efficacy has

been proved scientifically (current trend been proved scientifically (current trend application especially for degenerative application especially for degenerative

diseases certain viral infection and cancer)diseases certain viral infection and cancer)

The categories based on their processing The categories based on their processing developmentdevelopment

Herbal product falls into traditional medicinefalls into traditional medicine((jamujamu) ) when the when the process is simple and toxicity process is simple and toxicity evaluation is recommended (not compulsory)evaluation is recommended (not compulsory) Standardized extract preparationStandardized extract preparation when the when the process is more complexprocess is more complex than than jamujamu has been has been controlled chemically and has a preclinical controlled chemically and has a preclinical (toxicology pharmacology) evaluation(toxicology pharmacology) evaluation PhytopharmaceuticalPhytopharmaceutical when it has a when it has a complex complex process preclinical and clinical evaluation for process preclinical and clinical evaluation for safety and efficacy insurance is a mustsafety and efficacy insurance is a must

PHYTOPHARMACYPHYTOPHARMACY

TRADITIONAL MEDICINESTRADITIONAL MEDICINESWHICH HAVE BEEN PROVENWHICH HAVE BEEN PROVEN

SAFE EFECTIVE SAFE EFECTIVE QUALITY QUALITY

STANDARDIZEDSTANDARDIZED

MoH Decree No 760 1992

PHYTOPHARMACYPHYTOPHARMACY

TENSIGARDTENSIGARD

PHYTODIARPHYTODIAR

RHEUMANEERRHEUMANEER

X GRAX GRA

STIMUNOSTIMUNO

TRADITIONAL MEDICINESTRADITIONAL MEDICINESMoHMoH Decree 246MenkesPerV1990Decree 246MenkesPerV1990

PROHIBITED PROHIBITED

MIXEDCOMPOUNDED MIXEDCOMPOUNDED WITH MODERN MEDICINESWITH MODERN MEDICINES

Research and Systematization of Research and Systematization of Indonesian Traditional MedicinesIndonesian Traditional Medicines

clubsclubs Modern research on Indonesian herbal medicines in research Modern research on Indonesian herbal medicines in research institutions universities and industriesinstitutions universities and industries

clubsclubs

clubsclubs PublicationsPublicationsclubsclubs All of these efforts are All of these efforts are dedicated to the development of dedicated to the development of

Indonesian medicinal plantsIndonesian medicinal plants to be able to compete globallyto be able to compete globallyclubsclubs International requirements such as on International requirements such as on GMP GAP GLP ICHGMP GAP GLP ICH--

GCPGCP (The International Conference on Harmonization(The International Conference on Harmonization--Good Good Clinical Practice) Clinical Practice) Research Guidelines for Evaluating the Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines HACCPSafety and Efficacy of Herbal Medicines HACCP etc should etc should be followed be followed

bull Origin bull Distribution bull Resources bull Therapeutic usagebull Process bull Quality bull Safety bull Efficacy

Nine medicinal plants of first priority for Nine medicinal plants of first priority for phytopharmaceuticals phytopharmaceuticals

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

11

PsidiumPsidium guajavaguajava

Leaves Leaves immunomodulatorimmunomodulator

AstringentAstringentTraditional Most Traditional Most

famous preparation famous preparation for dengue treatmentfor dengue treatment

22

MorindaMorinda citrifoliacitrifolia

Fruit AntiFruit Anti--hypertensionhypertension

Leaves Leaves AntidiabeticAntidiabetic

MorindoneMorindone

O

O

OH

OH

O

O

OH

HO

OGlc(1-6)-Glc

Morindin

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

33

SizygiumSizygium polyanthumpolyanthum

Leaves Leaves AntidiabeticAntidiabetic

44

GuazumaGuazuma ulmifoliaulmifolia

Leaves Leaves AntiobesityAntiobesity

CatechinCatechin and and FriedelinFriedelin

55

ZingiberZingiber officinaleofficinale

Rhizomes Rhizomes CarminativeCarminativeStomachicStomachicStimulantsStimulants

GingerolGingerol

(CH2)nCH3

MeO

HO

O OH

OH

OH

HO O

OH

OH

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

66

Curcuma Curcuma domesticadomestica

Rhizomes Rhizomes AntilipedemicAntilipedemicAntiAnti--bacteria bacteria cholagogumcholagogum

ImmunoImmuno--stimulantsstimulants

CurcuminoidCurcuminoid

77

Curcuma Curcuma xanthorrhizaxanthorrhiza

Rhizomes Rhizomes HepatoprotectorHepatoprotector

CholereticCholeretic antiinflammationantiinflammation

CurcuminoidCurcuminoid

XanthorhizolXanthorhizol

88

AndrographisAndrographis paniculatapaniculata

Leaves Leaves Antipyretic antiAntipyretic anti--

ulcer ulcer antidiabeticantidiabetic

AndrographolideAndrographolide (1) (1) Neoandrographolide(2)Neoandrographolide(2)

O O

OMe

OH

MeO

HO

O

OH

O

OH

OH

(1)

OO O

O

HO

HO OH

OH

(2)

OH

O O

OMe

OH

MeO

HO

NoNo PlantPlant Medicinal Medicinal UsesUses BioBio--markermarker

99

CentellaCentella asiaticaasiatica

Aerial partAerial partVasodilatorVasodilator

ImmunoImmuno--stimulantsstimulants

AsiaticosideAsiaticoside and and MadecasolMadecasol

O

OH

HO

HO

O

O

HO

OH

HO

O

O

HO OH

OH

O

O

OH

OHHO

IntelectualIntelectual Property Property Right Protection Right Protection

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

The categories based on their processing The categories based on their processing developmentdevelopment

Herbal product falls into traditional medicinefalls into traditional medicine((jamujamu) ) when the when the process is simple and toxicity process is simple and toxicity evaluation is recommended (not compulsory)evaluation is recommended (not compulsory) Standardized extract preparationStandardized extract preparation when the when the process is more complexprocess is more complex than than jamujamu has been has been controlled chemically and has a preclinical controlled chemically and has a preclinical (toxicology pharmacology) evaluation(toxicology pharmacology) evaluation PhytopharmaceuticalPhytopharmaceutical when it has a when it has a complex complex process preclinical and clinical evaluation for process preclinical and clinical evaluation for safety and efficacy insurance is a mustsafety and efficacy insurance is a must

PHYTOPHARMACYPHYTOPHARMACY

TRADITIONAL MEDICINESTRADITIONAL MEDICINESWHICH HAVE BEEN PROVENWHICH HAVE BEEN PROVEN

SAFE EFECTIVE SAFE EFECTIVE QUALITY QUALITY

STANDARDIZEDSTANDARDIZED

MoH Decree No 760 1992

PHYTOPHARMACYPHYTOPHARMACY

TENSIGARDTENSIGARD

PHYTODIARPHYTODIAR

RHEUMANEERRHEUMANEER

X GRAX GRA

STIMUNOSTIMUNO

TRADITIONAL MEDICINESTRADITIONAL MEDICINESMoHMoH Decree 246MenkesPerV1990Decree 246MenkesPerV1990

PROHIBITED PROHIBITED

MIXEDCOMPOUNDED MIXEDCOMPOUNDED WITH MODERN MEDICINESWITH MODERN MEDICINES

Research and Systematization of Research and Systematization of Indonesian Traditional MedicinesIndonesian Traditional Medicines

clubsclubs Modern research on Indonesian herbal medicines in research Modern research on Indonesian herbal medicines in research institutions universities and industriesinstitutions universities and industries

clubsclubs

clubsclubs PublicationsPublicationsclubsclubs All of these efforts are All of these efforts are dedicated to the development of dedicated to the development of

Indonesian medicinal plantsIndonesian medicinal plants to be able to compete globallyto be able to compete globallyclubsclubs International requirements such as on International requirements such as on GMP GAP GLP ICHGMP GAP GLP ICH--

GCPGCP (The International Conference on Harmonization(The International Conference on Harmonization--Good Good Clinical Practice) Clinical Practice) Research Guidelines for Evaluating the Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines HACCPSafety and Efficacy of Herbal Medicines HACCP etc should etc should be followed be followed

bull Origin bull Distribution bull Resources bull Therapeutic usagebull Process bull Quality bull Safety bull Efficacy

Nine medicinal plants of first priority for Nine medicinal plants of first priority for phytopharmaceuticals phytopharmaceuticals

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

11

PsidiumPsidium guajavaguajava

Leaves Leaves immunomodulatorimmunomodulator

AstringentAstringentTraditional Most Traditional Most

famous preparation famous preparation for dengue treatmentfor dengue treatment

22

MorindaMorinda citrifoliacitrifolia

Fruit AntiFruit Anti--hypertensionhypertension

Leaves Leaves AntidiabeticAntidiabetic

MorindoneMorindone

O

O

OH

OH

O

O

OH

HO

OGlc(1-6)-Glc

Morindin

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

33

SizygiumSizygium polyanthumpolyanthum

Leaves Leaves AntidiabeticAntidiabetic

44

GuazumaGuazuma ulmifoliaulmifolia

Leaves Leaves AntiobesityAntiobesity

CatechinCatechin and and FriedelinFriedelin

55

ZingiberZingiber officinaleofficinale

Rhizomes Rhizomes CarminativeCarminativeStomachicStomachicStimulantsStimulants

GingerolGingerol

(CH2)nCH3

MeO

HO

O OH

OH

OH

HO O

OH

OH

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

66

Curcuma Curcuma domesticadomestica

Rhizomes Rhizomes AntilipedemicAntilipedemicAntiAnti--bacteria bacteria cholagogumcholagogum

ImmunoImmuno--stimulantsstimulants

CurcuminoidCurcuminoid

77

Curcuma Curcuma xanthorrhizaxanthorrhiza

Rhizomes Rhizomes HepatoprotectorHepatoprotector

CholereticCholeretic antiinflammationantiinflammation

CurcuminoidCurcuminoid

XanthorhizolXanthorhizol

88

AndrographisAndrographis paniculatapaniculata

Leaves Leaves Antipyretic antiAntipyretic anti--

ulcer ulcer antidiabeticantidiabetic

AndrographolideAndrographolide (1) (1) Neoandrographolide(2)Neoandrographolide(2)

O O

OMe

OH

MeO

HO

O

OH

O

OH

OH

(1)

OO O

O

HO

HO OH

OH

(2)

OH

O O

OMe

OH

MeO

HO

NoNo PlantPlant Medicinal Medicinal UsesUses BioBio--markermarker

99

CentellaCentella asiaticaasiatica

Aerial partAerial partVasodilatorVasodilator

ImmunoImmuno--stimulantsstimulants

AsiaticosideAsiaticoside and and MadecasolMadecasol

O

OH

HO

HO

O

O

HO

OH

HO

O

O

HO OH

OH

O

O

OH

OHHO

IntelectualIntelectual Property Property Right Protection Right Protection

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

PHYTOPHARMACYPHYTOPHARMACY

TRADITIONAL MEDICINESTRADITIONAL MEDICINESWHICH HAVE BEEN PROVENWHICH HAVE BEEN PROVEN

SAFE EFECTIVE SAFE EFECTIVE QUALITY QUALITY

STANDARDIZEDSTANDARDIZED

MoH Decree No 760 1992

PHYTOPHARMACYPHYTOPHARMACY

TENSIGARDTENSIGARD

PHYTODIARPHYTODIAR

RHEUMANEERRHEUMANEER

X GRAX GRA

STIMUNOSTIMUNO

TRADITIONAL MEDICINESTRADITIONAL MEDICINESMoHMoH Decree 246MenkesPerV1990Decree 246MenkesPerV1990

PROHIBITED PROHIBITED

MIXEDCOMPOUNDED MIXEDCOMPOUNDED WITH MODERN MEDICINESWITH MODERN MEDICINES

Research and Systematization of Research and Systematization of Indonesian Traditional MedicinesIndonesian Traditional Medicines

clubsclubs Modern research on Indonesian herbal medicines in research Modern research on Indonesian herbal medicines in research institutions universities and industriesinstitutions universities and industries

clubsclubs

clubsclubs PublicationsPublicationsclubsclubs All of these efforts are All of these efforts are dedicated to the development of dedicated to the development of

Indonesian medicinal plantsIndonesian medicinal plants to be able to compete globallyto be able to compete globallyclubsclubs International requirements such as on International requirements such as on GMP GAP GLP ICHGMP GAP GLP ICH--

GCPGCP (The International Conference on Harmonization(The International Conference on Harmonization--Good Good Clinical Practice) Clinical Practice) Research Guidelines for Evaluating the Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines HACCPSafety and Efficacy of Herbal Medicines HACCP etc should etc should be followed be followed

bull Origin bull Distribution bull Resources bull Therapeutic usagebull Process bull Quality bull Safety bull Efficacy

Nine medicinal plants of first priority for Nine medicinal plants of first priority for phytopharmaceuticals phytopharmaceuticals

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

11

PsidiumPsidium guajavaguajava

Leaves Leaves immunomodulatorimmunomodulator

AstringentAstringentTraditional Most Traditional Most

famous preparation famous preparation for dengue treatmentfor dengue treatment

22

MorindaMorinda citrifoliacitrifolia

Fruit AntiFruit Anti--hypertensionhypertension

Leaves Leaves AntidiabeticAntidiabetic

MorindoneMorindone

O

O

OH

OH

O

O

OH

HO

OGlc(1-6)-Glc

Morindin

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

33

SizygiumSizygium polyanthumpolyanthum

Leaves Leaves AntidiabeticAntidiabetic

44

GuazumaGuazuma ulmifoliaulmifolia

Leaves Leaves AntiobesityAntiobesity

CatechinCatechin and and FriedelinFriedelin

55

ZingiberZingiber officinaleofficinale

Rhizomes Rhizomes CarminativeCarminativeStomachicStomachicStimulantsStimulants

GingerolGingerol

(CH2)nCH3

MeO

HO

O OH

OH

OH

HO O

OH

OH

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

66

Curcuma Curcuma domesticadomestica

Rhizomes Rhizomes AntilipedemicAntilipedemicAntiAnti--bacteria bacteria cholagogumcholagogum

ImmunoImmuno--stimulantsstimulants

CurcuminoidCurcuminoid

77

Curcuma Curcuma xanthorrhizaxanthorrhiza

Rhizomes Rhizomes HepatoprotectorHepatoprotector

CholereticCholeretic antiinflammationantiinflammation

CurcuminoidCurcuminoid

XanthorhizolXanthorhizol

88

AndrographisAndrographis paniculatapaniculata

Leaves Leaves Antipyretic antiAntipyretic anti--

ulcer ulcer antidiabeticantidiabetic

AndrographolideAndrographolide (1) (1) Neoandrographolide(2)Neoandrographolide(2)

O O

OMe

OH

MeO

HO

O

OH

O

OH

OH

(1)

OO O

O

HO

HO OH

OH

(2)

OH

O O

OMe

OH

MeO

HO

NoNo PlantPlant Medicinal Medicinal UsesUses BioBio--markermarker

99

CentellaCentella asiaticaasiatica

Aerial partAerial partVasodilatorVasodilator

ImmunoImmuno--stimulantsstimulants

AsiaticosideAsiaticoside and and MadecasolMadecasol

O

OH

HO

HO

O

O

HO

OH

HO

O

O

HO OH

OH

O

O

OH

OHHO

IntelectualIntelectual Property Property Right Protection Right Protection

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

PHYTOPHARMACYPHYTOPHARMACY

TENSIGARDTENSIGARD

PHYTODIARPHYTODIAR

RHEUMANEERRHEUMANEER

X GRAX GRA

STIMUNOSTIMUNO

TRADITIONAL MEDICINESTRADITIONAL MEDICINESMoHMoH Decree 246MenkesPerV1990Decree 246MenkesPerV1990

PROHIBITED PROHIBITED

MIXEDCOMPOUNDED MIXEDCOMPOUNDED WITH MODERN MEDICINESWITH MODERN MEDICINES

Research and Systematization of Research and Systematization of Indonesian Traditional MedicinesIndonesian Traditional Medicines

clubsclubs Modern research on Indonesian herbal medicines in research Modern research on Indonesian herbal medicines in research institutions universities and industriesinstitutions universities and industries

clubsclubs

clubsclubs PublicationsPublicationsclubsclubs All of these efforts are All of these efforts are dedicated to the development of dedicated to the development of

Indonesian medicinal plantsIndonesian medicinal plants to be able to compete globallyto be able to compete globallyclubsclubs International requirements such as on International requirements such as on GMP GAP GLP ICHGMP GAP GLP ICH--

GCPGCP (The International Conference on Harmonization(The International Conference on Harmonization--Good Good Clinical Practice) Clinical Practice) Research Guidelines for Evaluating the Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines HACCPSafety and Efficacy of Herbal Medicines HACCP etc should etc should be followed be followed

bull Origin bull Distribution bull Resources bull Therapeutic usagebull Process bull Quality bull Safety bull Efficacy

Nine medicinal plants of first priority for Nine medicinal plants of first priority for phytopharmaceuticals phytopharmaceuticals

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

11

PsidiumPsidium guajavaguajava

Leaves Leaves immunomodulatorimmunomodulator

AstringentAstringentTraditional Most Traditional Most

famous preparation famous preparation for dengue treatmentfor dengue treatment

22

MorindaMorinda citrifoliacitrifolia

Fruit AntiFruit Anti--hypertensionhypertension

Leaves Leaves AntidiabeticAntidiabetic

MorindoneMorindone

O

O

OH

OH

O

O

OH

HO

OGlc(1-6)-Glc

Morindin

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

33

SizygiumSizygium polyanthumpolyanthum

Leaves Leaves AntidiabeticAntidiabetic

44

GuazumaGuazuma ulmifoliaulmifolia

Leaves Leaves AntiobesityAntiobesity

CatechinCatechin and and FriedelinFriedelin

55

ZingiberZingiber officinaleofficinale

Rhizomes Rhizomes CarminativeCarminativeStomachicStomachicStimulantsStimulants

GingerolGingerol

(CH2)nCH3

MeO

HO

O OH

OH

OH

HO O

OH

OH

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

66

Curcuma Curcuma domesticadomestica

Rhizomes Rhizomes AntilipedemicAntilipedemicAntiAnti--bacteria bacteria cholagogumcholagogum

ImmunoImmuno--stimulantsstimulants

CurcuminoidCurcuminoid

77

Curcuma Curcuma xanthorrhizaxanthorrhiza

Rhizomes Rhizomes HepatoprotectorHepatoprotector

CholereticCholeretic antiinflammationantiinflammation

CurcuminoidCurcuminoid

XanthorhizolXanthorhizol

88

AndrographisAndrographis paniculatapaniculata

Leaves Leaves Antipyretic antiAntipyretic anti--

ulcer ulcer antidiabeticantidiabetic

AndrographolideAndrographolide (1) (1) Neoandrographolide(2)Neoandrographolide(2)

O O

OMe

OH

MeO

HO

O

OH

O

OH

OH

(1)

OO O

O

HO

HO OH

OH

(2)

OH

O O

OMe

OH

MeO

HO

NoNo PlantPlant Medicinal Medicinal UsesUses BioBio--markermarker

99

CentellaCentella asiaticaasiatica

Aerial partAerial partVasodilatorVasodilator

ImmunoImmuno--stimulantsstimulants

AsiaticosideAsiaticoside and and MadecasolMadecasol

O

OH

HO

HO

O

O

HO

OH

HO

O

O

HO OH

OH

O

O

OH

OHHO

IntelectualIntelectual Property Property Right Protection Right Protection

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

TRADITIONAL MEDICINESTRADITIONAL MEDICINESMoHMoH Decree 246MenkesPerV1990Decree 246MenkesPerV1990

PROHIBITED PROHIBITED

MIXEDCOMPOUNDED MIXEDCOMPOUNDED WITH MODERN MEDICINESWITH MODERN MEDICINES

Research and Systematization of Research and Systematization of Indonesian Traditional MedicinesIndonesian Traditional Medicines

clubsclubs Modern research on Indonesian herbal medicines in research Modern research on Indonesian herbal medicines in research institutions universities and industriesinstitutions universities and industries

clubsclubs

clubsclubs PublicationsPublicationsclubsclubs All of these efforts are All of these efforts are dedicated to the development of dedicated to the development of

Indonesian medicinal plantsIndonesian medicinal plants to be able to compete globallyto be able to compete globallyclubsclubs International requirements such as on International requirements such as on GMP GAP GLP ICHGMP GAP GLP ICH--

GCPGCP (The International Conference on Harmonization(The International Conference on Harmonization--Good Good Clinical Practice) Clinical Practice) Research Guidelines for Evaluating the Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines HACCPSafety and Efficacy of Herbal Medicines HACCP etc should etc should be followed be followed

bull Origin bull Distribution bull Resources bull Therapeutic usagebull Process bull Quality bull Safety bull Efficacy

Nine medicinal plants of first priority for Nine medicinal plants of first priority for phytopharmaceuticals phytopharmaceuticals

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

11

PsidiumPsidium guajavaguajava

Leaves Leaves immunomodulatorimmunomodulator

AstringentAstringentTraditional Most Traditional Most

famous preparation famous preparation for dengue treatmentfor dengue treatment

22

MorindaMorinda citrifoliacitrifolia

Fruit AntiFruit Anti--hypertensionhypertension

Leaves Leaves AntidiabeticAntidiabetic

MorindoneMorindone

O

O

OH

OH

O

O

OH

HO

OGlc(1-6)-Glc

Morindin

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

33

SizygiumSizygium polyanthumpolyanthum

Leaves Leaves AntidiabeticAntidiabetic

44

GuazumaGuazuma ulmifoliaulmifolia

Leaves Leaves AntiobesityAntiobesity

CatechinCatechin and and FriedelinFriedelin

55

ZingiberZingiber officinaleofficinale

Rhizomes Rhizomes CarminativeCarminativeStomachicStomachicStimulantsStimulants

GingerolGingerol

(CH2)nCH3

MeO

HO

O OH

OH

OH

HO O

OH

OH

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

66

Curcuma Curcuma domesticadomestica

Rhizomes Rhizomes AntilipedemicAntilipedemicAntiAnti--bacteria bacteria cholagogumcholagogum

ImmunoImmuno--stimulantsstimulants

CurcuminoidCurcuminoid

77

Curcuma Curcuma xanthorrhizaxanthorrhiza

Rhizomes Rhizomes HepatoprotectorHepatoprotector

CholereticCholeretic antiinflammationantiinflammation

CurcuminoidCurcuminoid

XanthorhizolXanthorhizol

88

AndrographisAndrographis paniculatapaniculata

Leaves Leaves Antipyretic antiAntipyretic anti--

ulcer ulcer antidiabeticantidiabetic

AndrographolideAndrographolide (1) (1) Neoandrographolide(2)Neoandrographolide(2)

O O

OMe

OH

MeO

HO

O

OH

O

OH

OH

(1)

OO O

O

HO

HO OH

OH

(2)

OH

O O

OMe

OH

MeO

HO

NoNo PlantPlant Medicinal Medicinal UsesUses BioBio--markermarker

99

CentellaCentella asiaticaasiatica

Aerial partAerial partVasodilatorVasodilator

ImmunoImmuno--stimulantsstimulants

AsiaticosideAsiaticoside and and MadecasolMadecasol

O

OH

HO

HO

O

O

HO

OH

HO

O

O

HO OH

OH

O

O

OH

OHHO

IntelectualIntelectual Property Property Right Protection Right Protection

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

Research and Systematization of Research and Systematization of Indonesian Traditional MedicinesIndonesian Traditional Medicines

clubsclubs Modern research on Indonesian herbal medicines in research Modern research on Indonesian herbal medicines in research institutions universities and industriesinstitutions universities and industries

clubsclubs

clubsclubs PublicationsPublicationsclubsclubs All of these efforts are All of these efforts are dedicated to the development of dedicated to the development of

Indonesian medicinal plantsIndonesian medicinal plants to be able to compete globallyto be able to compete globallyclubsclubs International requirements such as on International requirements such as on GMP GAP GLP ICHGMP GAP GLP ICH--

GCPGCP (The International Conference on Harmonization(The International Conference on Harmonization--Good Good Clinical Practice) Clinical Practice) Research Guidelines for Evaluating the Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines HACCPSafety and Efficacy of Herbal Medicines HACCP etc should etc should be followed be followed

bull Origin bull Distribution bull Resources bull Therapeutic usagebull Process bull Quality bull Safety bull Efficacy

Nine medicinal plants of first priority for Nine medicinal plants of first priority for phytopharmaceuticals phytopharmaceuticals

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

11

PsidiumPsidium guajavaguajava

Leaves Leaves immunomodulatorimmunomodulator

AstringentAstringentTraditional Most Traditional Most

famous preparation famous preparation for dengue treatmentfor dengue treatment

22

MorindaMorinda citrifoliacitrifolia

Fruit AntiFruit Anti--hypertensionhypertension

Leaves Leaves AntidiabeticAntidiabetic

MorindoneMorindone

O

O

OH

OH

O

O

OH

HO

OGlc(1-6)-Glc

Morindin

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

33

SizygiumSizygium polyanthumpolyanthum

Leaves Leaves AntidiabeticAntidiabetic

44

GuazumaGuazuma ulmifoliaulmifolia

Leaves Leaves AntiobesityAntiobesity

CatechinCatechin and and FriedelinFriedelin

55

ZingiberZingiber officinaleofficinale

Rhizomes Rhizomes CarminativeCarminativeStomachicStomachicStimulantsStimulants

GingerolGingerol

(CH2)nCH3

MeO

HO

O OH

OH

OH

HO O

OH

OH

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

66

Curcuma Curcuma domesticadomestica

Rhizomes Rhizomes AntilipedemicAntilipedemicAntiAnti--bacteria bacteria cholagogumcholagogum

ImmunoImmuno--stimulantsstimulants

CurcuminoidCurcuminoid

77

Curcuma Curcuma xanthorrhizaxanthorrhiza

Rhizomes Rhizomes HepatoprotectorHepatoprotector

CholereticCholeretic antiinflammationantiinflammation

CurcuminoidCurcuminoid

XanthorhizolXanthorhizol

88

AndrographisAndrographis paniculatapaniculata

Leaves Leaves Antipyretic antiAntipyretic anti--

ulcer ulcer antidiabeticantidiabetic

AndrographolideAndrographolide (1) (1) Neoandrographolide(2)Neoandrographolide(2)

O O

OMe

OH

MeO

HO

O

OH

O

OH

OH

(1)

OO O

O

HO

HO OH

OH

(2)

OH

O O

OMe

OH

MeO

HO

NoNo PlantPlant Medicinal Medicinal UsesUses BioBio--markermarker

99

CentellaCentella asiaticaasiatica

Aerial partAerial partVasodilatorVasodilator

ImmunoImmuno--stimulantsstimulants

AsiaticosideAsiaticoside and and MadecasolMadecasol

O

OH

HO

HO

O

O

HO

OH

HO

O

O

HO OH

OH

O

O

OH

OHHO

IntelectualIntelectual Property Property Right Protection Right Protection

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

clubsclubs Modern research on Indonesian herbal medicines in research Modern research on Indonesian herbal medicines in research institutions universities and industriesinstitutions universities and industries

clubsclubs

clubsclubs PublicationsPublicationsclubsclubs All of these efforts are All of these efforts are dedicated to the development of dedicated to the development of

Indonesian medicinal plantsIndonesian medicinal plants to be able to compete globallyto be able to compete globallyclubsclubs International requirements such as on International requirements such as on GMP GAP GLP ICHGMP GAP GLP ICH--

GCPGCP (The International Conference on Harmonization(The International Conference on Harmonization--Good Good Clinical Practice) Clinical Practice) Research Guidelines for Evaluating the Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines HACCPSafety and Efficacy of Herbal Medicines HACCP etc should etc should be followed be followed

bull Origin bull Distribution bull Resources bull Therapeutic usagebull Process bull Quality bull Safety bull Efficacy

Nine medicinal plants of first priority for Nine medicinal plants of first priority for phytopharmaceuticals phytopharmaceuticals

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

11

PsidiumPsidium guajavaguajava

Leaves Leaves immunomodulatorimmunomodulator

AstringentAstringentTraditional Most Traditional Most

famous preparation famous preparation for dengue treatmentfor dengue treatment

22

MorindaMorinda citrifoliacitrifolia

Fruit AntiFruit Anti--hypertensionhypertension

Leaves Leaves AntidiabeticAntidiabetic

MorindoneMorindone

O

O

OH

OH

O

O

OH

HO

OGlc(1-6)-Glc

Morindin

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

33

SizygiumSizygium polyanthumpolyanthum

Leaves Leaves AntidiabeticAntidiabetic

44

GuazumaGuazuma ulmifoliaulmifolia

Leaves Leaves AntiobesityAntiobesity

CatechinCatechin and and FriedelinFriedelin

55

ZingiberZingiber officinaleofficinale

Rhizomes Rhizomes CarminativeCarminativeStomachicStomachicStimulantsStimulants

GingerolGingerol

(CH2)nCH3

MeO

HO

O OH

OH

OH

HO O

OH

OH

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

66

Curcuma Curcuma domesticadomestica

Rhizomes Rhizomes AntilipedemicAntilipedemicAntiAnti--bacteria bacteria cholagogumcholagogum

ImmunoImmuno--stimulantsstimulants

CurcuminoidCurcuminoid

77

Curcuma Curcuma xanthorrhizaxanthorrhiza

Rhizomes Rhizomes HepatoprotectorHepatoprotector

CholereticCholeretic antiinflammationantiinflammation

CurcuminoidCurcuminoid

XanthorhizolXanthorhizol

88

AndrographisAndrographis paniculatapaniculata

Leaves Leaves Antipyretic antiAntipyretic anti--

ulcer ulcer antidiabeticantidiabetic

AndrographolideAndrographolide (1) (1) Neoandrographolide(2)Neoandrographolide(2)

O O

OMe

OH

MeO

HO

O

OH

O

OH

OH

(1)

OO O

O

HO

HO OH

OH

(2)

OH

O O

OMe

OH

MeO

HO

NoNo PlantPlant Medicinal Medicinal UsesUses BioBio--markermarker

99

CentellaCentella asiaticaasiatica

Aerial partAerial partVasodilatorVasodilator

ImmunoImmuno--stimulantsstimulants

AsiaticosideAsiaticoside and and MadecasolMadecasol

O

OH

HO

HO

O

O

HO

OH

HO

O

O

HO OH

OH

O

O

OH

OHHO

IntelectualIntelectual Property Property Right Protection Right Protection

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

Nine medicinal plants of first priority for Nine medicinal plants of first priority for phytopharmaceuticals phytopharmaceuticals

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

11

PsidiumPsidium guajavaguajava

Leaves Leaves immunomodulatorimmunomodulator

AstringentAstringentTraditional Most Traditional Most

famous preparation famous preparation for dengue treatmentfor dengue treatment

22

MorindaMorinda citrifoliacitrifolia

Fruit AntiFruit Anti--hypertensionhypertension

Leaves Leaves AntidiabeticAntidiabetic

MorindoneMorindone

O

O

OH

OH

O

O

OH

HO

OGlc(1-6)-Glc

Morindin

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

33

SizygiumSizygium polyanthumpolyanthum

Leaves Leaves AntidiabeticAntidiabetic

44

GuazumaGuazuma ulmifoliaulmifolia

Leaves Leaves AntiobesityAntiobesity

CatechinCatechin and and FriedelinFriedelin

55

ZingiberZingiber officinaleofficinale

Rhizomes Rhizomes CarminativeCarminativeStomachicStomachicStimulantsStimulants

GingerolGingerol

(CH2)nCH3

MeO

HO

O OH

OH

OH

HO O

OH

OH

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

66

Curcuma Curcuma domesticadomestica

Rhizomes Rhizomes AntilipedemicAntilipedemicAntiAnti--bacteria bacteria cholagogumcholagogum

ImmunoImmuno--stimulantsstimulants

CurcuminoidCurcuminoid

77

Curcuma Curcuma xanthorrhizaxanthorrhiza

Rhizomes Rhizomes HepatoprotectorHepatoprotector

CholereticCholeretic antiinflammationantiinflammation

CurcuminoidCurcuminoid

XanthorhizolXanthorhizol

88

AndrographisAndrographis paniculatapaniculata

Leaves Leaves Antipyretic antiAntipyretic anti--

ulcer ulcer antidiabeticantidiabetic

AndrographolideAndrographolide (1) (1) Neoandrographolide(2)Neoandrographolide(2)

O O

OMe

OH

MeO

HO

O

OH

O

OH

OH

(1)

OO O

O

HO

HO OH

OH

(2)

OH

O O

OMe

OH

MeO

HO

NoNo PlantPlant Medicinal Medicinal UsesUses BioBio--markermarker

99

CentellaCentella asiaticaasiatica

Aerial partAerial partVasodilatorVasodilator

ImmunoImmuno--stimulantsstimulants

AsiaticosideAsiaticoside and and MadecasolMadecasol

O

OH

HO

HO

O

O

HO

OH

HO

O

O

HO OH

OH

O

O

OH

OHHO

IntelectualIntelectual Property Property Right Protection Right Protection

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

33

SizygiumSizygium polyanthumpolyanthum

Leaves Leaves AntidiabeticAntidiabetic

44

GuazumaGuazuma ulmifoliaulmifolia

Leaves Leaves AntiobesityAntiobesity

CatechinCatechin and and FriedelinFriedelin

55

ZingiberZingiber officinaleofficinale

Rhizomes Rhizomes CarminativeCarminativeStomachicStomachicStimulantsStimulants

GingerolGingerol

(CH2)nCH3

MeO

HO

O OH

OH

OH

HO O

OH

OH

OH

O

ORha

HO

OH O

OH

Quercitrin

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

66

Curcuma Curcuma domesticadomestica

Rhizomes Rhizomes AntilipedemicAntilipedemicAntiAnti--bacteria bacteria cholagogumcholagogum

ImmunoImmuno--stimulantsstimulants

CurcuminoidCurcuminoid

77

Curcuma Curcuma xanthorrhizaxanthorrhiza

Rhizomes Rhizomes HepatoprotectorHepatoprotector

CholereticCholeretic antiinflammationantiinflammation

CurcuminoidCurcuminoid

XanthorhizolXanthorhizol

88

AndrographisAndrographis paniculatapaniculata

Leaves Leaves Antipyretic antiAntipyretic anti--

ulcer ulcer antidiabeticantidiabetic

AndrographolideAndrographolide (1) (1) Neoandrographolide(2)Neoandrographolide(2)

O O

OMe

OH

MeO

HO

O

OH

O

OH

OH

(1)

OO O

O

HO

HO OH

OH

(2)

OH

O O

OMe

OH

MeO

HO

NoNo PlantPlant Medicinal Medicinal UsesUses BioBio--markermarker

99

CentellaCentella asiaticaasiatica

Aerial partAerial partVasodilatorVasodilator

ImmunoImmuno--stimulantsstimulants

AsiaticosideAsiaticoside and and MadecasolMadecasol

O

OH

HO

HO

O

O

HO

OH

HO

O

O

HO OH

OH

O

O

OH

OHHO

IntelectualIntelectual Property Property Right Protection Right Protection

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

NoNo PlantPlant Medicinal UsesMedicinal Uses BioBio--markermarker

66

Curcuma Curcuma domesticadomestica

Rhizomes Rhizomes AntilipedemicAntilipedemicAntiAnti--bacteria bacteria cholagogumcholagogum

ImmunoImmuno--stimulantsstimulants

CurcuminoidCurcuminoid

77

Curcuma Curcuma xanthorrhizaxanthorrhiza

Rhizomes Rhizomes HepatoprotectorHepatoprotector

CholereticCholeretic antiinflammationantiinflammation

CurcuminoidCurcuminoid

XanthorhizolXanthorhizol

88

AndrographisAndrographis paniculatapaniculata

Leaves Leaves Antipyretic antiAntipyretic anti--

ulcer ulcer antidiabeticantidiabetic

AndrographolideAndrographolide (1) (1) Neoandrographolide(2)Neoandrographolide(2)

O O

OMe

OH

MeO

HO

O

OH

O

OH

OH

(1)

OO O

O

HO

HO OH

OH

(2)

OH

O O

OMe

OH

MeO

HO

NoNo PlantPlant Medicinal Medicinal UsesUses BioBio--markermarker

99

CentellaCentella asiaticaasiatica

Aerial partAerial partVasodilatorVasodilator

ImmunoImmuno--stimulantsstimulants

AsiaticosideAsiaticoside and and MadecasolMadecasol

O

OH

HO

HO

O

O

HO

OH

HO

O

O

HO OH

OH

O

O

OH

OHHO

IntelectualIntelectual Property Property Right Protection Right Protection

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

NoNo PlantPlant Medicinal Medicinal UsesUses BioBio--markermarker

99

CentellaCentella asiaticaasiatica

Aerial partAerial partVasodilatorVasodilator

ImmunoImmuno--stimulantsstimulants

AsiaticosideAsiaticoside and and MadecasolMadecasol

O

OH

HO

HO

O

O

HO

OH

HO

O

O

HO OH

OH

O

O

OH

OHHO

IntelectualIntelectual Property Property Right Protection Right Protection

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

IntelectualIntelectual Property Property Right Protection Right Protection

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

LIPI Convention on Biological DiversityConvention on Biological Diversity(CBD)(CBD)

Signed in 1992Signed in 1992Indonesia ratified it through Law No Indonesia ratified it through Law No 5199451994States have States have sovereign rightssovereign rights over their over their own biological resourcesown biological resourcesStates are responsible for States are responsible for conserving conserving their their biological diversity and for using their biological diversity and for using their biological resources in a sustainable biological resources in a sustainable mannermanner

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

RELATED LAWS AND RULESRELATED LAWS AND RULESLIPI

Law No 51990 regarding Conservation of Natural Law No 51990 regarding Conservation of Natural Resources and Its EcosystemsResources and Its EcosystemsLaw No51994 regarding the Ratification of the Law No51994 regarding the Ratification of the United Nations Convention on Biological DiversityUnited Nations Convention on Biological DiversityLaw No 71994 regarding the Ratification of Law No 71994 regarding the Ratification of TRIPsTRIPsLaw No 182002 regarding National System on Law No 182002 regarding National System on Research Development and Application of Science Research Development and Application of Science and Technologyand TechnologyAll Indonesian IPR LawsAll Indonesian IPR Laws

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

CONCLUSIONCONCLUSIONIndonesia is a rich country biodiversity and traditional knowledIndonesia is a rich country biodiversity and traditional knowledge ge

including the including the trationaltrational medicine However in the global era medicine However in the global era the richness of biodiversity is not the determining factor for the richness of biodiversity is not the determining factor for prosperity of the people prosperity of the people

Knowledge how to develop its biodiversity and traditional Knowledge how to develop its biodiversity and traditional knowledge is important The key factor is how Indonesia knowledge is important The key factor is how Indonesia ability to convert knowledge into wealth and social good ability to convert knowledge into wealth and social good through the process of innovation through the process of innovation

It is a must for Indonesia to work collaboratively also with otIt is a must for Indonesia to work collaboratively also with other her contriescontries in traditional medicine improvement in traditional medicine improvement

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION

Thank you

• INDONESIAN COUNTRY REPORT ON TRADITIONAL MEDICINE
• Trend of Herbal Medicines in Indonesia
• PHYTOPHARMACY
• PHYTOPHARMACY
• TRADITIONAL MEDICINES
• Research and Systematization of Indonesian Traditional Medicines
• Intelectual Property Right Protection
• Convention on Biological Diversity(CBD)
• RELATED LAWS AND RULES
• CONCLUSION