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2 Scientific Report 2015

Index

Preface 5

1. Oncology Institute of Southern Switzerland (IOSI) 9

1.1 Medical Oncology Service 10 1.2 Radiation Oncology Service 12 1.3 Nuclear Medicine Service and PET/CT Center 16 1.4 Palliative Care Service 19 1.5 Haematology Service 20 1.6 Research Division 22 1.7 IOSI Nursing Service 38

2. Neurocenter of Southern Switzerland (NSI) 43

2.1 Multiple Sclerosis Center 45 2.2 Neuromuscolar Unit, Myosuisse Ticino Center 49 2.3 Sleep and Epilepsy Group 49 2.4 Movement Disorders Center 53 2.5 Stroke Center 56 2.6 Neuropsychology 59 2.7 Neurosurgery 62 2.8 Neuroradiology 64 2.9 Neuroanaesthesia 66 2.10 Laboratory for Biomedical Neurosciences (LBN) 68

3. EOC Multisite Departments and Services 73

3.1 EOC Department of Surgery 75 3.2 EOC Department of Internal Medicine 78 3.3 EOC Department of Intensive Care Medicine 90 3.4 EOC Department of Laboratory Medicine 93 3.5 Pediatrics Services 94 3.6 Anaesthesiology Services 99 3.7 Dermatology and Allergology/Clinical Immunology Services 100 3.8 Geriatric Service 101 3.9 Gynaecology and Obstetrics Services 102 3.10 Radiology Services 104

3

4. Swiss Clinical Trial Organization 109

4.1 EOC Clinical Trial Unit (CTU-EOC) 110

5. Scientific Research Advisory Board (ABREOC) 113

6. Official Registry of the EOC Studies 119

7. Publications in 2015 123

Publications in peer-reviewed journals in 2015 131 Publications in non-peer-reviewed journals in 2015 157 Publications in books in 2015 158

8. Appendices 161

Appendix 1 – Research projects funded by ABREOC in 2008 162 Appendix 2 – Research projects funded by ABREOC in 2009 164 Appendix 3 – Research projects funded by ABREOC in 2010 168 Appendix 4 – Research projects funded by ABREOC in 2011 174 Appendix 5 – Research projects funded by ABREOC in 2012 - 2013 178 Appendix 6 – Research projects funded by ABREOC in 2014 182 Appendix 7 – Research projects funded by ABREOC in 2015 186

Appendices

App

endi

ces


Lead Investigator Other researchers Institute Study title

Amountawarded

in CHF Status report Publication IF/Ranking

Andreas Perren Roberto Malacrida / Elena Iapichino/Davide Corbella / Fabrizio Barazzoni /Valentina di Bernardo / Ines Sperandino/ Cristina Sommacal

Regional Hospital of Bellinzonaand Valli - Intensive Care Medicine

Contenzione fisica vs farmacologica nel pazien-te intubato: conseguenze cliniche (Physical vs. drug restraint in the intubated patient: clinical consequences)

40,892.– Closed and published in Minerva Anestesiol. 81(10):1086-95,2015: “Physical restraint in the ICU: does it prevent device removal?”

2.134 /0.533

Gianfranco John Petri Fabio Garofalo / Robin Chanda /M. Lazzaro / Luca Deabate / F. Strano /Paola Genini / Ivana Roguljic

Regional Hospital of Bellinzonaand Valli - Orthopaedics

Diabete in ortopedia: gestione peri-operatoria del paziente diabetico - Infusione endovenosa continua d’insulina rapida (IECI) versus corre-zioni con insulina sottocute (regime standard) (Diabetes in orthopaedics: perioperative ma-nagement of the diabetic patient - a continuo-us intravenous infusion of rapid insulin (IEC) versus corrections with subcutaneous insulin - standard regimen -)

12,532.– Closed (final reportpresented)

Piercarlo Saletti Sara De Dosso / Milo Frattini /Luca Mazzucchelli / Emanuele Zucca

IOSI Oncology Analisi dei marcatori molecolari ERCC-1, TS, p53 e pTEN in pazienti affetti da adenocarcino-ma gastrico o della giunzione esofagogastrica operati radicalmente e sottoposti a chemiote-rapia precauzionale (Analysis of molecular mar-kers ERCC-1, TS, p53 and PTEN in patients af-fected by gastric or esophagogastric junction adenocarcinoma, who are radically operated and treated with preventive chemotherapy)

50,000.– Closed and published inCancer Chemother Pharmacol,72(1):159-65, 2013:“ERCC1 predicts outcomein patients with gastric cancertreated with adjuvantcisplatin-based chemotherapy”

2.769 /0.614

Olivia Pagani Monica Taborelli /Gabriella Bianchi-Micheli /Manuela Sarti

IOSI Oncology Analisi della qualità dell’informazione nei collo-qui di consulenza genetica per predisposizione a malattie tumorali (Analysis of the quality of information in genetic counseling for cancer disease susceptibility)

19,850.– Closed (publication still ongoing)

Luca Giovanella Luca Ceriani / Franco Keller IOSI Nuclear Medicine Metabolismo calcico nel morbo di Basedow (Calcium metabolism in Basedow disease)

12,870.– Closed and published in Eur J Clin Invest, 41(1):93-7, 2011:“Evaluation of serum parathyroidhormonerelated peptidein hyperthyroid patients”

2.734 /0.808

Luca Giovanella /Emanuele Zucca

Luca Mazzucchelli / Luca Ceriani /Sergio Suriano

IOSI Nuclear Medicine/Oncology Significato prognostico della 18fdg-PET/CT nei linfomi maligni (Prognostic significance of 18fdg-PET/CT in malignant lymphomas)

10,000.– Closed and published in Blood. 2015;126(8):950-56, 2015: “Utility of baseline 18FDG-PET/CT functio-nal parameters in defining progno-sis of primary mediastinal (thymic) large B-cell lymphoma”

10.452 / 0.985

Mario Bianchetti PJ. Schulz / Maria Caiata Zufferey Regional Hospital of Bellinzonaand Valli - Pediatrics

Convivere con una malattia cronica e genetica: il caso della sindrome di Gitelman (Living with a chronic and genetic disease: the Gitelman syndrome)

43,875.– Closed and published in Nephrol Dial Transplant, 27(8): 3196-3201, 2012: “Living with Gitelmandisease: an insight into patients’ daily experiences”

3.577 /0.867

Michele Ghielmini Jürg Stamm / Alden Moccia /Alessandra Fusconi

IOSI Oncology Preservazione della fertilità mediante criocon-servazione di tessuto ovarico (Fertility preser-vation through cryopreservation of ovarian tissue)

49,500.– In progress

Appendix 1 – Research projects funded by ABREOC in 2008

8. Appendices

163


Amountawarded


Andreas Perren Roberto Malacrida / Elena Iapichino/Davide Corbella / Fabrizio Barazzoni /Valentina di Bernardo / Ines Sperandino/ Cristina Sommacal

Regional Hospital of Bellinzonaand Valli - Intensive Care Medicine

Contenzione fisica vs farmacologica nel pazien-te intubato: conseguenze cliniche (Physical vs. drug restraint in the intubated patient: clinical consequences)

40,892.– Closed and published in Minerva Anestesiol. 81(10):1086-95,2015: “Physical restraint in the ICU: does it prevent device removal?”

2.134 /0.533

Gianfranco John Petri Fabio Garofalo / Robin Chanda /M. Lazzaro / Luca Deabate / F. Strano /Paola Genini / Ivana Roguljic

Regional Hospital of Bellinzonaand Valli - Orthopaedics

Diabete in ortopedia: gestione peri-operatoria del paziente diabetico - Infusione endovenosa continua d’insulina rapida (IECI) versus corre-zioni con insulina sottocute (regime standard) (Diabetes in orthopaedics: perioperative ma-nagement of the diabetic patient - a continuo-us intravenous infusion of rapid insulin (IEC) versus corrections with subcutaneous insulin - standard regimen -)

12,532.– Closed (final reportpresented)

Piercarlo Saletti Sara De Dosso / Milo Frattini /Luca Mazzucchelli / Emanuele Zucca

IOSI Oncology Analisi dei marcatori molecolari ERCC-1, TS, p53 e pTEN in pazienti affetti da adenocarcino-ma gastrico o della giunzione esofagogastrica operati radicalmente e sottoposti a chemiote-rapia precauzionale (Analysis of molecular mar-kers ERCC-1, TS, p53 and PTEN in patients af-fected by gastric or esophagogastric junction adenocarcinoma, who are radically operated and treated with preventive chemotherapy)

50,000.– Closed and published inCancer Chemother Pharmacol,72(1):159-65, 2013:“ERCC1 predicts outcomein patients with gastric cancertreated with adjuvantcisplatin-based chemotherapy”

2.769 /0.614

Olivia Pagani Monica Taborelli /Gabriella Bianchi-Micheli /Manuela Sarti

IOSI Oncology Analisi della qualità dell’informazione nei collo-qui di consulenza genetica per predisposizione a malattie tumorali (Analysis of the quality of information in genetic counseling for cancer disease susceptibility)


Luca Giovanella Luca Ceriani / Franco Keller IOSI Nuclear Medicine Metabolismo calcico nel morbo di Basedow (Calcium metabolism in Basedow disease)

12,870.– Closed and published in Eur J Clin Invest, 41(1):93-7, 2011:“Evaluation of serum parathyroidhormonerelated peptidein hyperthyroid patients”

2.734 /0.808

Luca Giovanella /Emanuele Zucca

Luca Mazzucchelli / Luca Ceriani /Sergio Suriano

IOSI Nuclear Medicine/Oncology Significato prognostico della 18fdg-PET/CT nei linfomi maligni (Prognostic significance of 18fdg-PET/CT in malignant lymphomas)

10,000.– Closed and published in Blood. 2015;126(8):950-56, 2015: “Utility of baseline 18FDG-PET/CT functio-nal parameters in defining progno-sis of primary mediastinal (thymic) large B-cell lymphoma”

10.452 / 0.985

Mario Bianchetti PJ. Schulz / Maria Caiata Zufferey Regional Hospital of Bellinzonaand Valli - Pediatrics

Convivere con una malattia cronica e genetica: il caso della sindrome di Gitelman (Living with a chronic and genetic disease: the Gitelman syndrome)

43,875.– Closed and published in Nephrol Dial Transplant, 27(8): 3196-3201, 2012: “Living with Gitelmandisease: an insight into patients’ daily experiences”

3.577 /0.867

Michele Ghielmini Jürg Stamm / Alden Moccia /Alessandra Fusconi

IOSI Oncology Preservazione della fertilità mediante criocon-servazione di tessuto ovarico (Fertility preser-vation through cryopreservation of ovarian tissue)


App

endi

ces



Amountawarded


Olivia Pagani Aron Goldhirsch / Franco Cavalli /Laura Richetti

IOSI Oncology Database CARMA: raccolta di dati clinici, re-trospettivi e prospettici, in pazienti con car-cinoma mammario per valutare l’impatto sull’outcome dei fattori prognostici e predittivi identificati alla diagnosi (CARMA database: col-lection of retrospective and prospective clini-cal data in breast cancer patients to assess the impact on outcome of prognostic and pre-dictive factors identified when diagnosed)


Luca Giovanella Franco Keller / Sergio Suriano IOSI Nuclear Medicine Procalcitonina e carcinoma midollare tiroideo (Procalcitonin and medullary thyroid carcino-ma)

32,080.– Closed and published in Clin Chem Lab Med, 51(7):1477-81, 2013: "Comparison of serum calcitonin and procalcitonin in detecting medullary thyroid carcinoma among patients with thyroid nodules"

2.707 / 0.833

Gian Paolo Ramelli Alessandra Ferrarini Regional Hospital of Bellinzonaand Valli - Pediatrics

Creazione di una banca dati dei pazienti pedia-trici con ritardo mentale assistiti dal Servizio di Neuropediatria dell’Ospedale San Giovanni di Bellinzona (Database creation of pediatric patients with mental retardation assisted by Neuropaediatrics Service of San Giovanni Ho-spital of Bellinzona)

7,500.– Closed and published in Dev Med Child Neurol, 56(3):290, 2014: “Chromosomal microarray among children with intellectual disability:a useful diagnostic tool for theclinical geneticist”

3.51 / 0.954

Martin Bolli Riccardo Vandoni / Luca Mazzucchelli /Milo Frattini

Regional Hospital of Bellinzonaand Valli - Surgery

Espressione e ruolo prognostico di marcatori molecolari, biologici e clinici nell'epatocarcino-ma (Expression and prognostic role of molecu-lar, biological and clinical markers in hepato-carcinoma)

48,230.– Closed (final report presented)

Carlo Cereda Claudio Bassetti / Claudio Städler /Laura Zampieri / Antonio Carota

Regional Hospital of Lugano- Neurocenter of SouthernSwitzerland (NSI)

Impatto sanitario dell’implementazione di una struttura di cure continue neurologiche (Stroke Unit) in seno al Neurocentro (EOC) della Svizzera Italiana - studio osservazionale community-based sulle malattie cerebrovasco-lari acute in territorio ticinese. (Health impact of a structure of continuous neurological tre-atment (stroke unit) within the Neurocenter (EOC) of Southern Switzerland - observational community-based study of acute cerebrova-scular diseases in Ticino)

48,500.– Closed and publishedin Cerebrovasc Dis. 39(2):102-9, 2015: "Beneficial effects ofa semi-intensive stroke unit are beyond the monitor"

3.754 / 0.806

Pierluigi Quadri Fabiano Meroni /Rita Pezzati /Damiano Zemp / Lorena Curia/Carola Celeste / Silvia Ambrogio /Simona Chiari / Francesca Gallina /Nicola Schiavone / Gianluca Guffanti

Regional Hospital of Mendrisio- Geriatrics

La paura di cadere negli anziani: intervento fisioterapico e approccio cognitivo (imagery) (Fear of falling in the elderly: physiotherapy in-tervention and cognitive approach (imagery))

28,750.– Closed (data analysis still ongoing)

Claudia Gamondi Maria Caiata Zufferey / Joyce Pellandini IOSI Oncology (Palliative Care Unit) Assisted Suicide: attitudes and experiences of bereaved families and beloved ones. An explo-ratory study

69,300.– Closed and published in Ann Oncol, 24(6):1639-44, 2013: "Families’ experiences with patients who died after assisted suicide:a retrospective interview studyin Southern Switzerland"

7.04 / 0.916


165


Amountawarded


Olivia Pagani Aron Goldhirsch / Franco Cavalli /Laura Richetti

IOSI Oncology Database CARMA: raccolta di dati clinici, re-trospettivi e prospettici, in pazienti con car-cinoma mammario per valutare l’impatto sull’outcome dei fattori prognostici e predittivi identificati alla diagnosi (CARMA database: col-lection of retrospective and prospective clini-cal data in breast cancer patients to assess the impact on outcome of prognostic and pre-dictive factors identified when diagnosed)


Luca Giovanella Franco Keller / Sergio Suriano IOSI Nuclear Medicine Procalcitonina e carcinoma midollare tiroideo (Procalcitonin and medullary thyroid carcino-ma)

32,080.– Closed and published in Clin Chem Lab Med, 51(7):1477-81, 2013: "Comparison of serum calcitonin and procalcitonin in detecting medullary thyroid carcinoma among patients with thyroid nodules"

2.707 / 0.833

Gian Paolo Ramelli Alessandra Ferrarini Regional Hospital of Bellinzonaand Valli - Pediatrics

Creazione di una banca dati dei pazienti pedia-trici con ritardo mentale assistiti dal Servizio di Neuropediatria dell’Ospedale San Giovanni di Bellinzona (Database creation of pediatric patients with mental retardation assisted by Neuropaediatrics Service of San Giovanni Ho-spital of Bellinzona)

7,500.– Closed and published in Dev Med Child Neurol, 56(3):290, 2014: “Chromosomal microarray among children with intellectual disability:a useful diagnostic tool for theclinical geneticist”

3.51 / 0.954

Martin Bolli Riccardo Vandoni / Luca Mazzucchelli /Milo Frattini

Regional Hospital of Bellinzonaand Valli - Surgery

Espressione e ruolo prognostico di marcatori molecolari, biologici e clinici nell'epatocarcino-ma (Expression and prognostic role of molecu-lar, biological and clinical markers in hepato-carcinoma)


Carlo Cereda Claudio Bassetti / Claudio Städler /Laura Zampieri / Antonio Carota


Impatto sanitario dell’implementazione di una struttura di cure continue neurologiche (Stroke Unit) in seno al Neurocentro (EOC) della Svizzera Italiana - studio osservazionale community-based sulle malattie cerebrovasco-lari acute in territorio ticinese. (Health impact of a structure of continuous neurological tre-atment (stroke unit) within the Neurocenter (EOC) of Southern Switzerland - observational community-based study of acute cerebrova-scular diseases in Ticino)

48,500.– Closed and publishedin Cerebrovasc Dis. 39(2):102-9, 2015: "Beneficial effects ofa semi-intensive stroke unit are beyond the monitor"

3.754 / 0.806

Pierluigi Quadri Fabiano Meroni /Rita Pezzati /Damiano Zemp / Lorena Curia/Carola Celeste / Silvia Ambrogio /Simona Chiari / Francesca Gallina /Nicola Schiavone / Gianluca Guffanti

Regional Hospital of Mendrisio- Geriatrics

La paura di cadere negli anziani: intervento fisioterapico e approccio cognitivo (imagery) (Fear of falling in the elderly: physiotherapy in-tervention and cognitive approach (imagery))


Claudia Gamondi Maria Caiata Zufferey / Joyce Pellandini IOSI Oncology (Palliative Care Unit) Assisted Suicide: attitudes and experiences of bereaved families and beloved ones. An explo-ratory study

69,300.– Closed and published in Ann Oncol, 24(6):1639-44, 2013: "Families’ experiences with patients who died after assisted suicide:a retrospective interview studyin Southern Switzerland"

7.04 / 0.916

App

endi

ces



Amountawarded


Emanuele Zucca Francesco Bertoni / Marco Zaffalon /Cassio Polpo de Campos

IOSI Oncology Sviluppo di nuovi algoritmi per l’identificazione di modelli prognostici in pazienti affetti da linfo-mi mediante l’ottimizzazione della gestione dei dati mancanti (Development of new algorithms for the identification of prognostic models in patients with lymphomas by optimizing the ma-nagement of missing data)

36,000.– Closed and published in Comput Stat Data Anal. 93:373–87, 2016: “Bayesian network data imputation with application to survival tree analysis”

1.4 /0.745

Marcello Di Valentino Augusto Gallino / Stefano Muzzarelli Regional Hospital of Bellinzonaand Valli - Cardiology

No Smoke Pub Study 15,475.– Closed and published in Eur J Public Health. 25(2):195-9, 2015: "Re-duction of ST-elevationmyocardial infarction in CantonTicino (Switzerland) after smoking bans in enclosed public places -No Smoke Pub Study"

2.591 / 0.803

Michele Ghielmini Oreste Mora / Lucia Marelli /Carla Pedrazzani / Monica Bianchi /Mauro Tettamanti / Pierluigi Quadri

IOSI Oncology Fattibilità e accettabilità di una valutazione rapida multidimensionale per il paziente on-cologico anziano: studio pilota osservazionale (Feasibility and acceptability of a quick multidi-mensional assessment for the elderly cancer patient: an observational pilot study)


167


Amountawarded


Emanuele Zucca Francesco Bertoni / Marco Zaffalon /Cassio Polpo de Campos

IOSI Oncology Sviluppo di nuovi algoritmi per l’identificazione di modelli prognostici in pazienti affetti da linfo-mi mediante l’ottimizzazione della gestione dei dati mancanti (Development of new algorithms for the identification of prognostic models in patients with lymphomas by optimizing the ma-nagement of missing data)

36,000.– Closed and published in Comput Stat Data Anal. 93:373–87, 2016: “Bayesian network data imputation with application to survival tree analysis”

1.4 /0.745

Marcello Di Valentino Augusto Gallino / Stefano Muzzarelli Regional Hospital of Bellinzonaand Valli - Cardiology

No Smoke Pub Study 15,475.– Closed and published in Eur J Public Health. 25(2):195-9, 2015: "Re-duction of ST-elevationmyocardial infarction in CantonTicino (Switzerland) after smoking bans in enclosed public places -No Smoke Pub Study"

2.591 / 0.803

Michele Ghielmini Oreste Mora / Lucia Marelli /Carla Pedrazzani / Monica Bianchi /Mauro Tettamanti / Pierluigi Quadri

IOSI Oncology Fattibilità e accettabilità di una valutazione rapida multidimensionale per il paziente on-cologico anziano: studio pilota osservazionale (Feasibility and acceptability of a quick multidi-mensional assessment for the elderly cancer patient: an observational pilot study)


App

endi

ces



Amountawarded


Rolf Wyttenbach Zsolt Szücs-Farkas / Nathalie Médioni Regional Hospital of Bellinzonaand Valli - Radiology

Extracardiac Findings on Cardiac Magnetic Re-sonance Imaging Studies

22,474.– Closed and published in EurRadiol, 22(6):1295-302, 2012:"Extracardiac findings detected by cardiac magnetic resonance imaging"

2.369 / 0.648

Luca Giovanella Franco Keller / Sergio Suriano /Luca Ceriani

IOSI Nuclear Medicine Dosaggio calcitonina su agoaspirato tiroideo (Dosage of calcitonin in thyroid fine-needle aspiration)

24,000.– Closed and published in DiagnCytopathol, 41(3): 226-229, 2013: “Calcitonin measurement on fineneedle washouts: preanalyticalissues and normal referencevalues” and in Clin Endocrinol (Oxf), 80(1):135-140, 2014: “Calcitonin measurement in aspiration needle washout fluids has higher sensitivity than cytology in detecting medullary thyroid cancer: a retrospective multicentre study”

1.121 /0.3

(DiagnCytopathol);

3.457 / 0.627

(ClinEndocrinol)

Luca Giovanella Luca Ceriani / Sergio Suriano /Riccardo Ricci

IOSI Nuclear Medicine Diagnosi differenziale dei noduli tiroidei con ci-tologia non-diagnostica mediante 18FDG-PET/CT (Differential diagnosis of thyroid nodules with non-diagnostic cytology by 18FDG-PET/CT)

65,000.– Closed and published in Eur JEndocrinol. 2016 Mar 10. pii:EJE-15-1199: "Thyroid nodules with indeterminate cytology: prospective comparison between 18F-FDG-PET/CT, multiparametric neck ultraso-nography, 99mTc-MIBI scintigraphy and histology"

4.069 / 0.738

Luca Giovannacci Raffaele Rosso / Filippo Del Grande /Reto Canevascini / Stephane Schlunke / Josua van den Berg / Hans Stricker

Regional Hospital of Lugano- Vascular Surgery

Fattibilità di un programma di screening eco-grafico dell'aneurisma dell'aorta addominale nella popolazione afferente all'Ospedale Regio-nale di Lugano (Feasibility of a abdominal aor-tic aneurysm ultrasound screening program in the population served by Regional Hospital of Lugano)


Gian Paolo Ramelli Tamara Gonzalez / Nadia Zanda /Emanuelle Rossini

Regional Hospital of Bellinzonaand Valli - Pediatrics

Creazione di una banca dati dei pazienti pedia-trici con disturbo dello spettro autistico assi-stiti dal Servizio di Neuropediatria dell’Ospedale San Giovanni di Bellinzona (Database creation of paediatric patients with autism spectrum di-sorder assisted by neuropaediatrics Service of San Giovanni Hospital of Bellinzona)

7,000.– Closed and published in Eur J Paediatr Neurol, 19 (3):386-387, 2015: “High prevalenceof pathologic copy number variants detected by chromosomal microarray in Swiss-Italian children with autism spectrum disorders”

2.301 / 0.759

Michele Ghielmini Andrea Bordoni / Luca Mazzucchelli /Alessandra Spitale

IOSI Oncology Indicatori di qualità nel trattamento oncolo-gico: progetto di ricerca nella Svizzera Ita-liana (Indicators of Quality of Cancer Care in Southern Switzerland)

60,000.– Closed and published in BMJ Open, 3(7), 2013: “Quality indicatorsof clinical cancer care (QC3)in colorectal cancer”; in Schweizer Krebsbulletin, 3: 205-8, 2012: “Quality Indicators of ClinicalCancer Care (QC3) in the territory of Canton Ticino: a population-based study”; in Tribuna Medica Ticinese, 76: 51-5, 2011: “Indicatoridi qualità nelle cure oncologichestudio QC3”- (Quality indicatorsof clinical cancer care study QC3)

2.271 / 0.742

(BMJ Open)


169


Amountawarded


Rolf Wyttenbach Zsolt Szücs-Farkas / Nathalie Médioni Regional Hospital of Bellinzonaand Valli - Radiology

Extracardiac Findings on Cardiac Magnetic Re-sonance Imaging Studies

22,474.– Closed and published in EurRadiol, 22(6):1295-302, 2012:"Extracardiac findings detected by cardiac magnetic resonance imaging"

2.369 / 0.648

Luca Giovanella Franco Keller / Sergio Suriano /Luca Ceriani

IOSI Nuclear Medicine Dosaggio calcitonina su agoaspirato tiroideo (Dosage of calcitonin in thyroid fine-needle aspiration)

24,000.– Closed and published in DiagnCytopathol, 41(3): 226-229, 2013: “Calcitonin measurement on fineneedle washouts: preanalyticalissues and normal referencevalues” and in Clin Endocrinol (Oxf), 80(1):135-140, 2014: “Calcitonin measurement in aspiration needle washout fluids has higher sensitivity than cytology in detecting medullary thyroid cancer: a retrospective multicentre study”

1.121 /0.3

(DiagnCytopathol);

3.457 / 0.627

(ClinEndocrinol)

Luca Giovanella Luca Ceriani / Sergio Suriano /Riccardo Ricci

IOSI Nuclear Medicine Diagnosi differenziale dei noduli tiroidei con ci-tologia non-diagnostica mediante 18FDG-PET/CT (Differential diagnosis of thyroid nodules with non-diagnostic cytology by 18FDG-PET/CT)

65,000.– Closed and published in Eur JEndocrinol. 2016 Mar 10. pii:EJE-15-1199: "Thyroid nodules with indeterminate cytology: prospective comparison between 18F-FDG-PET/CT, multiparametric neck ultraso-nography, 99mTc-MIBI scintigraphy and histology"

4.069 / 0.738

Luca Giovannacci Raffaele Rosso / Filippo Del Grande /Reto Canevascini / Stephane Schlunke / Josua van den Berg / Hans Stricker

Regional Hospital of Lugano- Vascular Surgery

Fattibilità di un programma di screening eco-grafico dell'aneurisma dell'aorta addominale nella popolazione afferente all'Ospedale Regio-nale di Lugano (Feasibility of a abdominal aor-tic aneurysm ultrasound screening program in the population served by Regional Hospital of Lugano)


Gian Paolo Ramelli Tamara Gonzalez / Nadia Zanda /Emanuelle Rossini


Creazione di una banca dati dei pazienti pedia-trici con disturbo dello spettro autistico assi-stiti dal Servizio di Neuropediatria dell’Ospedale San Giovanni di Bellinzona (Database creation of paediatric patients with autism spectrum di-sorder assisted by neuropaediatrics Service of San Giovanni Hospital of Bellinzona)

7,000.– Closed and published in Eur J Paediatr Neurol, 19 (3):386-387, 2015: “High prevalenceof pathologic copy number variants detected by chromosomal microarray in Swiss-Italian children with autism spectrum disorders”

2.301 / 0.759

Michele Ghielmini Andrea Bordoni / Luca Mazzucchelli /Alessandra Spitale

IOSI Oncology Indicatori di qualità nel trattamento oncolo-gico: progetto di ricerca nella Svizzera Ita-liana (Indicators of Quality of Cancer Care in Southern Switzerland)

60,000.– Closed and published in BMJ Open, 3(7), 2013: “Quality indicatorsof clinical cancer care (QC3)in colorectal cancer”; in Schweizer Krebsbulletin, 3: 205-8, 2012: “Quality Indicators of ClinicalCancer Care (QC3) in the territory of Canton Ticino: a population-based study”; in Tribuna Medica Ticinese, 76: 51-5, 2011: “Indicatoridi qualità nelle cure oncologichestudio QC3”- (Quality indicatorsof clinical cancer care study QC3)

2.271 / 0.742

(BMJ Open)

App

endi

ces



Amountawarded


Augusto Gallino Marcello Di Valentino / Julija Klimusina / Regional Group of Ticino cardiologists

Regional Hospital of Bellinzonaand Valli - Cardiology

Sindrome X coronarica: ruolo della funzione endoteliale: un sotto-studio della coorte sviz-zera italiana del registro italiano sulla sindro-me X (Cardiac X Syndrome: role of endothelial function: a substudy of the Swiss-Italian cohort of the italian Registry on X Syndrome)

53,559.– Closed and publishedin Cardiovascular Medicine,16(1): 20–8, 2013: “Cardiac Xsyndrome: an overview of theliterature and the local experience in Southern Switzerland”

1.51 / 0.367

Andrea Menafoglio Marcello Di Valentino / Reto Pezzoli /Julija Klimusina / Augusto Gallino


Impatto dello screening cardiovascolare con elettrocardiogramma in giovani atleti (Impact of cardiovascular screening with ECG in young (12-35 years) competitive athletes)

64,500.– Closed and publishedin Cardiovascular Medicine,16:11-9, 2013:“Cardiovascular screening in young athletes: controversies and feasi-bility”

1.51 / 0.367

Dario Valcarenghi Paola Di Giulio / Monica Bianchi /Carla Pedrazzani / Sonia Tosi Casado /Christa Pedrazzoli Hutz

IOSI Nursing Service La sorveglianza del dolore allo IOSI: a che pun-to siamo? (Pain monitoring at the IOSI: where are we?)

8,135.45 Closed (final report and presented as scientific communications at national conferences)

Claudio Gobbi Chiara Zecca / Ursula Candrian /Marta Garcia Calle / Mara Gola /Costanzo Limoni / Liliane Petrini


A prospective, randomized, double-blind, pla-cebo-controlled, parallel-group, phase IV study of oral prednisone taper vs. placebo following intravenous steroids for the treatment of acu-te relapses in multiple sclerosis within the Ti-cino cohort


Piercarlo Saletti Milo Frattini / Luca Mazzucchelli /Sara De Dosso

IOSI Oncology Ruolo predittivo di EGFR, PIK3CA e PTEN nella risposta al trattamento radio-chemioterapico preoperatorio in pazienti affetti da carcinoma rettale localmente avanzato (Predictive role of EGFR, PIK3CA and PTEN in the response to preoperative radio-chemotherapy in patients with locally advanced rectal carcinoma)


Roberto Malacrida Valentina Di Bernardo / Nicola Grignoli /Chantal Marazia / Andreas Perren /Michael Llamas / Alberto Pagnamenta / Ines Sperandio / Rosanna Di Nocolantonio / Attilio Sicilia / Barbara Schulte

Regional Hospital of Lugano- Intensive Care Medicine

L'intimità nelle cure intensive del Canton Ticino (Intimacy in the intensive care unit of the Can-ton Ticino)

56,324.– Closed and published in J Crit Care. 30(5):866-70, 2015:"Sharing intimacy in "open"intensive care units"

1.995 / 0.269

Alberto Pagnamenta Moreno Doninelli / Michael Llamas / An-dreas Perren / Roberto Malacrida / Kurt Schmidlin / Hans Ulrich Rothen

Regional Hospital of Mendrisio- Intensive Care Medicine

Impatto di una strategia comunicativa sulla soddisfazione dei familiari in medicina intensi-va (Impact of a communication strategy on the relatives' satisfaction in intensive care medi-cine)

78,167.– Closed and published in ActaAnaesthesiol Scand. 2016 Jan 29. doi: 10.1111/aas.12692:"Impact of a communicationstrategy on family satisfactionin the intensive care unit"

2.322 / 0.567

Manuela Sarti Sandra Pinton / Pina Carbone / Carlo Cata-pano / Enrico Roggero / Franco Cavalli

IOSI Oncology Expression analysis of putative stem cell mar-kers in human malignant prostate tumour and prognostic implications

49,449.– Closed and presented as scientific communications at national and international conferencesand published in Nature, 515(7525): 134-7, 2014:"Tumour-infiltrating Gr-1+ myeloid cells antagonize senescencein cancer"

41.456 /1

171


Amountawarded


Augusto Gallino Marcello Di Valentino / Julija Klimusina / Regional Group of Ticino cardiologists


Sindrome X coronarica: ruolo della funzione endoteliale: un sotto-studio della coorte sviz-zera italiana del registro italiano sulla sindro-me X (Cardiac X Syndrome: role of endothelial function: a substudy of the Swiss-Italian cohort of the italian Registry on X Syndrome)

53,559.– Closed and publishedin Cardiovascular Medicine,16(1): 20–8, 2013: “Cardiac Xsyndrome: an overview of theliterature and the local experience in Southern Switzerland”

1.51 / 0.367

Andrea Menafoglio Marcello Di Valentino / Reto Pezzoli /Julija Klimusina / Augusto Gallino


Impatto dello screening cardiovascolare con elettrocardiogramma in giovani atleti (Impact of cardiovascular screening with ECG in young (12-35 years) competitive athletes)

64,500.– Closed and publishedin Cardiovascular Medicine,16:11-9, 2013:“Cardiovascular screening in young athletes: controversies and feasi-bility”

1.51 / 0.367

Dario Valcarenghi Paola Di Giulio / Monica Bianchi /Carla Pedrazzani / Sonia Tosi Casado /Christa Pedrazzoli Hutz

IOSI Nursing Service La sorveglianza del dolore allo IOSI: a che pun-to siamo? (Pain monitoring at the IOSI: where are we?)

8,135.45 Closed (final report and presented as scientific communications at national conferences)

Claudio Gobbi Chiara Zecca / Ursula Candrian /Marta Garcia Calle / Mara Gola /Costanzo Limoni / Liliane Petrini


A prospective, randomized, double-blind, pla-cebo-controlled, parallel-group, phase IV study of oral prednisone taper vs. placebo following intravenous steroids for the treatment of acu-te relapses in multiple sclerosis within the Ti-cino cohort


Piercarlo Saletti Milo Frattini / Luca Mazzucchelli /Sara De Dosso

IOSI Oncology Ruolo predittivo di EGFR, PIK3CA e PTEN nella risposta al trattamento radio-chemioterapico preoperatorio in pazienti affetti da carcinoma rettale localmente avanzato (Predictive role of EGFR, PIK3CA and PTEN in the response to preoperative radio-chemotherapy in patients with locally advanced rectal carcinoma)


Roberto Malacrida Valentina Di Bernardo / Nicola Grignoli /Chantal Marazia / Andreas Perren /Michael Llamas / Alberto Pagnamenta / Ines Sperandio / Rosanna Di Nocolantonio / Attilio Sicilia / Barbara Schulte

Regional Hospital of Lugano- Intensive Care Medicine

L'intimità nelle cure intensive del Canton Ticino (Intimacy in the intensive care unit of the Can-ton Ticino)

56,324.– Closed and published in J Crit Care. 30(5):866-70, 2015:"Sharing intimacy in "open"intensive care units"

1.995 / 0.269

Alberto Pagnamenta Moreno Doninelli / Michael Llamas / An-dreas Perren / Roberto Malacrida / Kurt Schmidlin / Hans Ulrich Rothen

Regional Hospital of Mendrisio- Intensive Care Medicine

Impatto di una strategia comunicativa sulla soddisfazione dei familiari in medicina intensi-va (Impact of a communication strategy on the relatives' satisfaction in intensive care medi-cine)

78,167.– Closed and published in ActaAnaesthesiol Scand. 2016 Jan 29. doi: 10.1111/aas.12692:"Impact of a communicationstrategy on family satisfactionin the intensive care unit"

2.322 / 0.567

Manuela Sarti Sandra Pinton / Pina Carbone / Carlo Cata-pano / Enrico Roggero / Franco Cavalli

IOSI Oncology Expression analysis of putative stem cell mar-kers in human malignant prostate tumour and prognostic implications

49,449.– Closed and presented as scientific communications at national and international conferencesand published in Nature, 515(7525): 134-7, 2014:"Tumour-infiltrating Gr-1+ myeloid cells antagonize senescencein cancer"

41.456 /1

App

endi

ces



Amountawarded


Dario Valcarenghi Monica Bianchi /Claudia Gamondi Palmesino /Sonia Tosi Casado /Christa Pedrazzoli Hutz /Carla Pedrazzani

IOSI Nursing Service / Oncology L'inserimento di un programma di arte-terapia per pazienti oncologici ricoverati allo IOSI: uno studio pilota (Introduction of art therapy pro-gram for cancer patients admitted to the IOSI: a pilot study)

33,495.92

Closed (final report and presented as scientific communicationsat national and internationalconferences)

Enrico Roggero Barbara Marongiu / Mariarosa Pascale / Andrea Alimonti / Flavio Stoffel /Franco Cavalli

IOSI Oncology Studio pilota per confrontare i profili genomi-ci e metabolomici di pazienti con cancro alla prostata alla diagnosi e durante la progressio-ne della malattia con lo scopo di identificare specifiche alterazioni genetiche e metaboliche intra-individuali (Pilot study comparing geno-mic and metabolomic profiling of patients with prostate cancer at diagnosis and during dise-ase progression to find specific intra-individual genetic and metabolic alterations)

85,210.– In progress (the preliminary results were published in Tribuna medica ticinese, 79: 245-8, 2014:"Gestione multidisciplinare deipazienti con tumori urogenitali presso l'ente ospedaliero cantonale" (Multidisciplinary managementof patients with urogenital tumors at the ente ospedaliero cantonale)

173


Amountawarded


Dario Valcarenghi Monica Bianchi /Claudia Gamondi Palmesino /Sonia Tosi Casado /Christa Pedrazzoli Hutz /Carla Pedrazzani

IOSI Nursing Service / Oncology L'inserimento di un programma di arte-terapia per pazienti oncologici ricoverati allo IOSI: uno studio pilota (Introduction of art therapy pro-gram for cancer patients admitted to the IOSI: a pilot study)

33,495.92

Closed (final report and presented as scientific communicationsat national and internationalconferences)

Enrico Roggero Barbara Marongiu / Mariarosa Pascale / Andrea Alimonti / Flavio Stoffel /Franco Cavalli

IOSI Oncology Studio pilota per confrontare i profili genomi-ci e metabolomici di pazienti con cancro alla prostata alla diagnosi e durante la progressio-ne della malattia con lo scopo di identificare specifiche alterazioni genetiche e metaboliche intra-individuali (Pilot study comparing geno-mic and metabolomic profiling of patients with prostate cancer at diagnosis and during dise-ase progression to find specific intra-individual genetic and metabolic alterations)

85,210.– In progress (the preliminary results were published in Tribuna medica ticinese, 79: 245-8, 2014:"Gestione multidisciplinare deipazienti con tumori urogenitali presso l'ente ospedaliero cantonale" (Multidisciplinary managementof patients with urogenital tumors at the ente ospedaliero cantonale)

App

endi

ces



Amountawarded


Luca Giovanella Massimo Bongiovanni / Sergio Suriano IOSI Nuclear Medicine Noduli tiroidei con citologia indeterminata: ruo-lo diagnostico di elastosonografia e marcatori immunocitochimici. (Thyroid nodules with inde-terminate cytology: diagnostic role of elasto-graphy and immunocytochemical markers)

55,400.– Closed and published in Eur J Nucl Med Mol Imaging. 2015 Dec 23. [Epub ahead of print]: "Molecular imaging with 99mTc-MIBI andmolecular testing for mutationsin differentiating benign frommalignant follicular neoplasm:a prospective comparison"

5.383 / 0.968

Claudia Gamondi Chantal Corti Polti / Murielle Pott IOSI Oncology (Palliative Care Unit) Parteciper à un suicide assisté: étude explo-ratoire sur l'expérience des proches et leurs représentations de la fin de vie, de la mort et du deuil. (The experience of the family in assi-sted suicide)

6,287.– Closed and publishedin Anthropologie et Santé.Patients contemporains 2. 10, 2015: "Quand accompagnementde fin de vie rime avec assistanceau suicide : l’expérience desproches en Suisse latine".Another Publication still ongoing

Claudia Gamondi Paola Di Giulio / Michele Egloff IOSI Oncology (Palliative Care Unit) Epidemiology of dying in Southern Switzerland: circumstances of death

66,600.– Closed (data analysis still ongoing. Preliminary results publishedin SUPSI Health. 11, 2015:“Laboratorio di ricerca. Comesi muore negli ospedali ticinesi: alcuni dati preliminari dello studio FIT (Fine Vita in Ticino)”(Research laboratory. How to die in Ticino hospitals: some preliminary dataof the study “End Life in Ticino”)

Dimitri Christoforidis Mike Schmalzbauer / Alberto Posabella / Raffaele Rosso

Regional Hospital of Lugano - Surgery Due tecniche chirurgiche per il trattamento delle cisti sacro-coccigee: uno studio rando-mizzato e controllato (Two surgical techniques for the treatment of sacro-coccygeal cysts: a randomized and controlled study)


Florian Bihl Antonio Lanzavecchia Regional Hospital of Bellinzonaand Valli - Gastroenterology

Valutazione della risposta immunitaria cellula-re nei confronti del virus dell'epatite B in vari stadi dell'infezione: caratterizzazione di rispo-ste di linfociti T e B ed analisi di nuovi epitopi virali (Evaluation of the cellular immune respon-se against the hepatitis B virus in various sta-ges of infection: characterization of responses of T and B lymphocytes and analysis of new viral epitopes)


Christina Caporale /Carlo Cereda

Claudio Bassetti / Fabio Conti /Claudio Petrillo / René Müri /Thomas Nyffeler / Antonino Uncini / Daniel Zutter


Riabilitazione combinata alla stimolazione bie-misferica transcranica con corrente continua diretta in pazienti con ictus subacuto al fine di aumentare il recupero motorio degli arti su-periori. (Rehabilitation combined with bihemi-spheric transcranial direct current stimulation in subacute ischemic stroke to increase upper limb motor recovery) The Re.Com.Bi.Ne. (Rehabilitation Combined with Bihemispheric Neuromodulation) post stroke study



175


Amountawarded


Luca Giovanella Massimo Bongiovanni / Sergio Suriano IOSI Nuclear Medicine Noduli tiroidei con citologia indeterminata: ruo-lo diagnostico di elastosonografia e marcatori immunocitochimici. (Thyroid nodules with inde-terminate cytology: diagnostic role of elasto-graphy and immunocytochemical markers)

55,400.– Closed and published in Eur J Nucl Med Mol Imaging. 2015 Dec 23. [Epub ahead of print]: "Molecular imaging with 99mTc-MIBI andmolecular testing for mutationsin differentiating benign frommalignant follicular neoplasm:a prospective comparison"

5.383 / 0.968

Claudia Gamondi Chantal Corti Polti / Murielle Pott IOSI Oncology (Palliative Care Unit) Parteciper à un suicide assisté: étude explo-ratoire sur l'expérience des proches et leurs représentations de la fin de vie, de la mort et du deuil. (The experience of the family in assi-sted suicide)

6,287.– Closed and publishedin Anthropologie et Santé.Patients contemporains 2. 10, 2015: "Quand accompagnementde fin de vie rime avec assistanceau suicide : l’expérience desproches en Suisse latine".Another Publication still ongoing

Claudia Gamondi Paola Di Giulio / Michele Egloff IOSI Oncology (Palliative Care Unit) Epidemiology of dying in Southern Switzerland: circumstances of death

66,600.– Closed (data analysis still ongoing. Preliminary results publishedin SUPSI Health. 11, 2015:“Laboratorio di ricerca. Comesi muore negli ospedali ticinesi: alcuni dati preliminari dello studio FIT (Fine Vita in Ticino)”(Research laboratory. How to die in Ticino hospitals: some preliminary dataof the study “End Life in Ticino”)

Dimitri Christoforidis Mike Schmalzbauer / Alberto Posabella / Raffaele Rosso

Regional Hospital of Lugano - Surgery Due tecniche chirurgiche per il trattamento delle cisti sacro-coccigee: uno studio rando-mizzato e controllato (Two surgical techniques for the treatment of sacro-coccygeal cysts: a randomized and controlled study)


Florian Bihl Antonio Lanzavecchia Regional Hospital of Bellinzonaand Valli - Gastroenterology

Valutazione della risposta immunitaria cellula-re nei confronti del virus dell'epatite B in vari stadi dell'infezione: caratterizzazione di rispo-ste di linfociti T e B ed analisi di nuovi epitopi virali (Evaluation of the cellular immune respon-se against the hepatitis B virus in various sta-ges of infection: characterization of responses of T and B lymphocytes and analysis of new viral epitopes)


Christina Caporale /Carlo Cereda

Claudio Bassetti / Fabio Conti /Claudio Petrillo / René Müri /Thomas Nyffeler / Antonino Uncini / Daniel Zutter


Riabilitazione combinata alla stimolazione bie-misferica transcranica con corrente continua diretta in pazienti con ictus subacuto al fine di aumentare il recupero motorio degli arti su-periori. (Rehabilitation combined with bihemi-spheric transcranial direct current stimulation in subacute ischemic stroke to increase upper limb motor recovery) The Re.Com.Bi.Ne. (Rehabilitation Combined with Bihemispheric Neuromodulation) post stroke study

40,000.– In progressA

ppen

dice

s



Amountawarded


Franco Keller Mauro Imperiali / Roberto Della Bruna/ Luca Martinolli

EOLAB Department Valutazione dell'introduzione di apparecchi POCT per l'emogasanalisi nell'urgenza ospeda-liera e pre-ospedaliera (Evaluation of the intro-duction of POCT devices for blood gas analysis in the hospital and pre-hospital emergency)

3,300.– Closed (presented at "congresso Svizzero di medicina di laboratorio - Swiss conference of laboratory medicine (Swiss medLab)"

Marco Pons Andrea Azzola / Alessia Riglietti /Claudio Bassetti / Mauro Manconi /Carlo Cereda / Liliane Petrini / Guido Ferretti / Massimo Pagani /Fabio Esposito / Costanzo Limoni

Regional Hospital of Lugano- Internal Medicine

Le apnee centrali in corso di TIA/ictus ische-mico: elementi clinici, prognostici e fiosiopa-tologici (The central apneas during the TIA / ischemic stroke: clinical, prognostic and phy-siopathological elements)

93,114.– In progress (data analysisstill ongoing)

Rolf Wyttenbach Stefano Colagrande / Francesco Regini / Elisa Ardemagni

Regional Hospital of Bellinzonaand Valli - Radiology

Multi-parametric evaluation of liver perfusion by MR-Dwl under fasting and postprandial con-ditions in healthly volunteers: correlation with quantitative phase-contrast portal venous flow measurements

40,433.– Closed and published in J Comput Assist Tomogr, 2015 Feb 13[Epub ahead of print]: "Assessment of Liver Perfusion by IntraVoxel Incoherent Motion (IVIM) Magnetic Resonance-Diffusion-WeightedImaging: Correlation WithPhase-Contrast Portal VenousFlow Measurements"

1.411 / 0.352

Salvatore Galati Carsten Möller / Claudio Städler /Chiara Prosperetti / Mauro Manconi /Simone Sarasso / Marcello Massimini


Ruolo della sleep homeostasis nello sviluppo delle discinesie indotte dalla L-Dopa nei pa-zienti affetti da malattia di Parkinson in fase avanzata (Role of sleep homeostasis in the development of dyskinesias induced by L-dopa in patients with advanced stage of Parkinson's disease)


Gian Franco Pesce Ngwa Che Azinwi / Antonella Richetti / Jolanda De Jong

IOSI Radio-Oncology Protocollo di irradiazione cerebrale ipofrazio-nata o radiochirurgia (IGRT o modalità stere-otassica della cavità di resezione in pazienti sottoposti ad asportazione chirurgica di meta-stasi cerebrale singola da tumori solidi (Hypo-fractionated cerebral irradiation protocol or radiosurgery (IGRT or stereotaxic mode) of the resection cavity in patients undergoing surgi-cal removal of single cerebral metastasis from solid tumours)


177


Amountawarded


Franco Keller Mauro Imperiali / Roberto Della Bruna/ Luca Martinolli

EOLAB Department Valutazione dell'introduzione di apparecchi POCT per l'emogasanalisi nell'urgenza ospeda-liera e pre-ospedaliera (Evaluation of the intro-duction of POCT devices for blood gas analysis in the hospital and pre-hospital emergency)

3,300.– Closed (presented at "congresso Svizzero di medicina di laboratorio - Swiss conference of laboratory medicine (Swiss medLab)"

Marco Pons Andrea Azzola / Alessia Riglietti /Claudio Bassetti / Mauro Manconi /Carlo Cereda / Liliane Petrini / Guido Ferretti / Massimo Pagani /Fabio Esposito / Costanzo Limoni

Regional Hospital of Lugano- Internal Medicine

Le apnee centrali in corso di TIA/ictus ische-mico: elementi clinici, prognostici e fiosiopa-tologici (The central apneas during the TIA / ischemic stroke: clinical, prognostic and phy-siopathological elements)

93,114.– In progress (data analysisstill ongoing)

Rolf Wyttenbach Stefano Colagrande / Francesco Regini / Elisa Ardemagni

Regional Hospital of Bellinzonaand Valli - Radiology

Multi-parametric evaluation of liver perfusion by MR-Dwl under fasting and postprandial con-ditions in healthly volunteers: correlation with quantitative phase-contrast portal venous flow measurements

40,433.– Closed and published in J Comput Assist Tomogr, 2015 Feb 13[Epub ahead of print]: "Assessment of Liver Perfusion by IntraVoxel Incoherent Motion (IVIM) Magnetic Resonance-Diffusion-WeightedImaging: Correlation WithPhase-Contrast Portal VenousFlow Measurements"

1.411 / 0.352

Salvatore Galati Carsten Möller / Claudio Städler /Chiara Prosperetti / Mauro Manconi /Simone Sarasso / Marcello Massimini


Ruolo della sleep homeostasis nello sviluppo delle discinesie indotte dalla L-Dopa nei pa-zienti affetti da malattia di Parkinson in fase avanzata (Role of sleep homeostasis in the development of dyskinesias induced by L-dopa in patients with advanced stage of Parkinson's disease)


Gian Franco Pesce Ngwa Che Azinwi / Antonella Richetti / Jolanda De Jong

IOSI Radio-Oncology Protocollo di irradiazione cerebrale ipofrazio-nata o radiochirurgia (IGRT o modalità stere-otassica della cavità di resezione in pazienti sottoposti ad asportazione chirurgica di meta-stasi cerebrale singola da tumori solidi (Hypo-fractionated cerebral irradiation protocol or radiosurgery (IGRT or stereotaxic mode) of the resection cavity in patients undergoing surgi-cal removal of single cerebral metastasis from solid tumours)


App

endi

ces



Amountawarded


Andrea Menafoglio Marcello Di Valentino / Patrick Siragusa / Gian-Antonio Romano / Reto Pezzoli /Giorgio Moschovitis


Impatto dello screening cardiovascolare in at-leti master tra 35 e 65 anni (Pre-participation Screening and Assessment of Cardiovascular diseases in Master Athletes from 35 to 65 years of age - PSA-Master’s Study)

60,173.– Closed and published in Br J Sports Med. 49(11):757-61, 2015:“Cardiovascular evaluationof middle-aged individuals engaged in high-intensity sport activities: implications for workload, yieldand economic costs”

5.025 / 0.985

Leonardo Sacco Guido Ongaro / Fabiano Meroni /Riccardo Pignatti / Claudio Staedler /Franco Keller


L'alterazione di A-BETA 42, TAU e FOSFO-TAU nel liquor di pazienti con deficit cognitivo lieve (CDR 0.5) sono indice indiretto di accumulo di amiloide e danno neuronale. I test di memo-ria semantica, memoria ecologica e dual task sono congruenti con il processo neurodegene-rativo? (Alteration in A-BETA 42, TAU and PHO-SPHO-TAU in the cerebrospinal fluid of patients with mild cognitive impairment (CDR 0.5) is an indirect sign of amyloid accumulation and neu-ronal damage. Are semantic memory, ecolo-gical memory and dual task tests consistent with the neurodegenerative process?)


Enos Bernasconi Francesco Bertoni / Emanuele Zucca /Stephan Dirnhofer

Regional Hospital of Lugano- Infectious Diseases Service

A survey of treatment modalities and outcome analysis of HIV-related B-cell lymphomas from the Swiss HIV Cohort Study


Dario Valcarenghi Monica Bianchi / Carla Pedrazzani /Agostino Chiriatti / Massimiliano Zanon

IOSI Nursing Service L'educazione del paziente al trattamento far-macologico antitumorale orale (Patient educa-tion to oral cancer therapy)


Luciano Wannesson Milo Frattini / Luca Mazzucchelli /Francesca Molinari

IOSI Oncology Analisi dell'espressione genica di ROR1 nei car-cinomi polmonari: un nuovo marcatore nell'ot-tica di nuove terapie bersaglio-specifiche (Gene expression analysis of ROR1 in lung carcino-mas: a new marker in view of new target-spe-cific therapies)


Franco Cavalli /Manuela Sarti

Gianluca Civenni / Flavio Stoffel /Carlo Catapano / Giuseppina Carbone

IOSI Oncology Isolation and characterization of epithelial stem cells from human prostate biopsies


Piercarlo Saletti /Cristiana Sessa

Sara De Dosso / Anastasios Stathis IOSI Oncology Studio di Fase I con la combinazione di che-mioterapia contenente platino e endometacina (Phase I study evaluating indomethacin in com-bination with platinum-based chemotherapy)


Claudio Gobbi Emanuele Pravatà / Chiara Zecca /Valeria Pifferini / Navarajah Nadarajah / Alessandro Cianfoni / Leonardo Sacco / Riccardo Pignatti


Brain Default Mode and Attention Network MR Functional Connectivity Changes After Task-in-duced Precipitation of Cognitive Fatigue in Pa-tients with Multiple Sclerosis

50,000.– Closed (final report and a poster presented at conferences)

Mauro Imperiali /Luca Giovanella

Franco Keller EOLAB Department /IOSI Nuclear Medicine

Studio di marcatori biochimici tiroidei (Study of thyroid biochemical markers)


Appendix 5 – Research projects funded by ABREOC in 2012 - 2013

179


Amountawarded


Andrea Menafoglio Marcello Di Valentino / Patrick Siragusa / Gian-Antonio Romano / Reto Pezzoli /Giorgio Moschovitis


Impatto dello screening cardiovascolare in at-leti master tra 35 e 65 anni (Pre-participation Screening and Assessment of Cardiovascular diseases in Master Athletes from 35 to 65 years of age - PSA-Master’s Study)

60,173.– Closed and published in Br J Sports Med. 49(11):757-61, 2015:“Cardiovascular evaluationof middle-aged individuals engaged in high-intensity sport activities: implications for workload, yieldand economic costs”

5.025 / 0.985

Leonardo Sacco Guido Ongaro / Fabiano Meroni /Riccardo Pignatti / Claudio Staedler /Franco Keller


L'alterazione di A-BETA 42, TAU e FOSFO-TAU nel liquor di pazienti con deficit cognitivo lieve (CDR 0.5) sono indice indiretto di accumulo di amiloide e danno neuronale. I test di memo-ria semantica, memoria ecologica e dual task sono congruenti con il processo neurodegene-rativo? (Alteration in A-BETA 42, TAU and PHO-SPHO-TAU in the cerebrospinal fluid of patients with mild cognitive impairment (CDR 0.5) is an indirect sign of amyloid accumulation and neu-ronal damage. Are semantic memory, ecolo-gical memory and dual task tests consistent with the neurodegenerative process?)


Enos Bernasconi Francesco Bertoni / Emanuele Zucca /Stephan Dirnhofer

Regional Hospital of Lugano- Infectious Diseases Service

A survey of treatment modalities and outcome analysis of HIV-related B-cell lymphomas from the Swiss HIV Cohort Study


Dario Valcarenghi Monica Bianchi / Carla Pedrazzani /Agostino Chiriatti / Massimiliano Zanon

IOSI Nursing Service L'educazione del paziente al trattamento far-macologico antitumorale orale (Patient educa-tion to oral cancer therapy)


Luciano Wannesson Milo Frattini / Luca Mazzucchelli /Francesca Molinari

IOSI Oncology Analisi dell'espressione genica di ROR1 nei car-cinomi polmonari: un nuovo marcatore nell'ot-tica di nuove terapie bersaglio-specifiche (Gene expression analysis of ROR1 in lung carcino-mas: a new marker in view of new target-spe-cific therapies)



Gianluca Civenni / Flavio Stoffel /Carlo Catapano / Giuseppina Carbone

IOSI Oncology Isolation and characterization of epithelial stem cells from human prostate biopsies


Piercarlo Saletti /Cristiana Sessa

Sara De Dosso / Anastasios Stathis IOSI Oncology Studio di Fase I con la combinazione di che-mioterapia contenente platino e endometacina (Phase I study evaluating indomethacin in com-bination with platinum-based chemotherapy)


Claudio Gobbi Emanuele Pravatà / Chiara Zecca /Valeria Pifferini / Navarajah Nadarajah / Alessandro Cianfoni / Leonardo Sacco / Riccardo Pignatti


Brain Default Mode and Attention Network MR Functional Connectivity Changes After Task-in-duced Precipitation of Cognitive Fatigue in Pa-tients with Multiple Sclerosis

50,000.– Closed (final report and a poster presented at conferences)

Mauro Imperiali /Luca Giovanella

Franco Keller EOLAB Department /IOSI Nuclear Medicine

Studio di marcatori biochimici tiroidei (Study of thyroid biochemical markers)


App

endi

ces



Amountawarded


Olivier Giannini Damiano Zemp / Claudio Cereghetti /Mauro Tettamanti / Pierluigi Quadri

Regional Hospital of Mendrisio- Internal Medicine

Influenza dell'emodialisi sull'attività fisica e sulle capacità motorie in pazienti con insufficienza renale cronica stadio 5 (K/DOQI) (Influence of haemodyalisis on physical activity and motor skills of patients with chronic kidney disease, stage 5 (K/DOQI)


Alessandra PiaPorretta

Augusto Gallino / Peter J. Schwartz /Isabella Sudano /Juljia Klimusina


Cardiomiopatia di Tako-Tsubo e Sindrome X Cardiaca: nuove prospettive patofisiologiche nell'ambito di due cardiopatie orfane (Tako-Tsu-bo Cardiomyopathy and Cardiac Syndrome X: New Insights into the pathophysiology of two orphan cardiac diseases)

66,501.– Closed (data analysis stillongoing. Preliminary resultspresented at conferences anda case report published inCirculation. 132(24):e377-9, 2015:"Three Recurrent Episodesof pical-Ballooning TakotsuboCardiomyopathy in a Man")

14.43 /1


Carlo Catapano / Giuseppina Carbone /Enrico Roggero / Sandra Pinton /Ramon Garcia-Escudero / Flavio Stoffel / Brunello Mazzola / Fernando Jermini /Mauro Castelnuovo

IOSI Oncology Circulating microRNAs in plasma/serum as biomarkers for prostate cancer


Michele Ghielmini Vilma Ratti / Cristina Marini /Carla Pedrazzani

IOSI Oncology Studio caso-controllo dell'impatto di una scelta terapeutica basata sulla valutazione multidi-mensionale del paziente oncologico in età ge-riatrica (Case-control study of the impact of a therapeutic choice based on multi-dimensional assessment of elderly cancer patients)


181


Amountawarded


Olivier Giannini Damiano Zemp / Claudio Cereghetti /Mauro Tettamanti / Pierluigi Quadri

Regional Hospital of Mendrisio- Internal Medicine

Influenza dell'emodialisi sull'attività fisica e sulle capacità motorie in pazienti con insufficienza renale cronica stadio 5 (K/DOQI) (Influence of haemodyalisis on physical activity and motor skills of patients with chronic kidney disease, stage 5 (K/DOQI)


Alessandra PiaPorretta

Augusto Gallino / Peter J. Schwartz /Isabella Sudano /Juljia Klimusina


Cardiomiopatia di Tako-Tsubo e Sindrome X Cardiaca: nuove prospettive patofisiologiche nell'ambito di due cardiopatie orfane (Tako-Tsu-bo Cardiomyopathy and Cardiac Syndrome X: New Insights into the pathophysiology of two orphan cardiac diseases)

66,501.– Closed (data analysis stillongoing. Preliminary resultspresented at conferences anda case report published inCirculation. 132(24):e377-9, 2015:"Three Recurrent Episodesof pical-Ballooning TakotsuboCardiomyopathy in a Man")

14.43 /1


Carlo Catapano / Giuseppina Carbone /Enrico Roggero / Sandra Pinton /Ramon Garcia-Escudero / Flavio Stoffel / Brunello Mazzola / Fernando Jermini /Mauro Castelnuovo

IOSI Oncology Circulating microRNAs in plasma/serum as biomarkers for prostate cancer


Michele Ghielmini Vilma Ratti / Cristina Marini /Carla Pedrazzani

IOSI Oncology Studio caso-controllo dell'impatto di una scelta terapeutica basata sulla valutazione multidi-mensionale del paziente oncologico in età ge-riatrica (Case-control study of the impact of a therapeutic choice based on multi-dimensional assessment of elderly cancer patients)


App

endi

ces



Amountawarded

in CHF Status report Publication IF/

Ranking

Luca Giovanella Luca Ceriani / Pierpaolo Trimboli IOSI Nuclear Medicine Analisi Ecostrutturale quantitativa: ruolo dia-gnostico differenziale nella patologia nodulare tiroidea (Echostructural quantitative analysis: differential diagnostic role in nodular thyroid disease)


Luca Gabutti Igor Salvadé / Giorgia Bianchi Regional Hospital of Locarno- Internal Medicine

A. Valore predittivo del magnesio ionizzato sulla magnesemia totale e variazioni intra-dialitiche: uno studio di popolazione; B. Con-seguenze emodinamiche del cambiamento di concentrazione di magnesio nel dializzato: uno studio in cross-over (A. Predictive value of ionized magnesium on total magnesemia and intradialytic variations: a population study; B. Consequences of hemodynamic change in magnesium concentration in the dialysate: a cross-over study)


Silvia Miano Mauro Manconi / Valdo Pezzoli /Gian Paolo Ramelli


Markers polisonnografici del disturbo dell’at-tenzione ed iperattività in età pediatrica e di-sturbi del sonno (Polysomnographic markers of attention deficit and hyperactivity disorder in pediatric age and sleep disorders)


Stephany Fulda Chiara Prosperetti Regional Hospital of Lugano- Neurocenter of SouthernSwitzerland (NSI)

Infra-slow oscillations during sleep in healthy subjects and subjects with restless legssyndrome/periodic leg movements during sle-ep (RLS/PLMS)

45,080.20 In progress

Enrico Roggero Luca Mazzucchelli / Mariarosa Pascale IOSI Oncology Studio pilota epidemiologico sulla prevalenza del virus del papilloma umano nei soggetti af-fetti da carcinoma della prostata nella popo-lazione ticinese (Epidemiological pilot study on prevalence of human papillomavirus in indivi-duals with prostate cancer in the population in Ticino)


Giorgio Treglia Ramin Sadeghi / Salvatore Annunziata IOSI Nuclear Medicine Meta-analisi sull’accuratezza diagnostica della PET/TC con fluorodesossiglucosio nello stu-dio dei tumori delle vie biliari (Meta-analysis on diagnostic accuracy of PET/CT scans with fluorodeoxyglucose in the study of biliary tract tumours)

10,000.– In progress (publications: Biomed Res Int. 2014:247693, 2014:"Diagnostic accuracy offluorine-18-fluorodeoxyglucosepositron emission tomographyin the evaluation of the primary tumor in patients withcholangiocarcinoma:a meta-analysis"; World JGastroenterol. 21(40):11481-8, 2015: "Diagnostic accuracyof fluorine-18-fluorodeoxyglucose positron emission tomographyin gallbladder cancer:A meta-analysis"

1.579 /0.348

(BiomedRes Int);

2.369 /0.467

(World JGastroenterol)


183


Amountawarded

in CHF Status report Publication IF/

Ranking

Luca Giovanella Luca Ceriani / Pierpaolo Trimboli IOSI Nuclear Medicine Analisi Ecostrutturale quantitativa: ruolo dia-gnostico differenziale nella patologia nodulare tiroidea (Echostructural quantitative analysis: differential diagnostic role in nodular thyroid disease)


Luca Gabutti Igor Salvadé / Giorgia Bianchi Regional Hospital of Locarno- Internal Medicine

A. Valore predittivo del magnesio ionizzato sulla magnesemia totale e variazioni intra-dialitiche: uno studio di popolazione; B. Con-seguenze emodinamiche del cambiamento di concentrazione di magnesio nel dializzato: uno studio in cross-over (A. Predictive value of ionized magnesium on total magnesemia and intradialytic variations: a population study; B. Consequences of hemodynamic change in magnesium concentration in the dialysate: a cross-over study)


Silvia Miano Mauro Manconi / Valdo Pezzoli /Gian Paolo Ramelli


Markers polisonnografici del disturbo dell’at-tenzione ed iperattività in età pediatrica e di-sturbi del sonno (Polysomnographic markers of attention deficit and hyperactivity disorder in pediatric age and sleep disorders)


Stephany Fulda Chiara Prosperetti Regional Hospital of Lugano- Neurocenter of SouthernSwitzerland (NSI)

Infra-slow oscillations during sleep in healthy subjects and subjects with restless legssyndrome/periodic leg movements during sle-ep (RLS/PLMS)

45,080.20 In progress

Enrico Roggero Luca Mazzucchelli / Mariarosa Pascale IOSI Oncology Studio pilota epidemiologico sulla prevalenza del virus del papilloma umano nei soggetti af-fetti da carcinoma della prostata nella popo-lazione ticinese (Epidemiological pilot study on prevalence of human papillomavirus in indivi-duals with prostate cancer in the population in Ticino)


Giorgio Treglia Ramin Sadeghi / Salvatore Annunziata IOSI Nuclear Medicine Meta-analisi sull’accuratezza diagnostica della PET/TC con fluorodesossiglucosio nello stu-dio dei tumori delle vie biliari (Meta-analysis on diagnostic accuracy of PET/CT scans with fluorodeoxyglucose in the study of biliary tract tumours)

10,000.– In progress (publications: Biomed Res Int. 2014:247693, 2014:"Diagnostic accuracy offluorine-18-fluorodeoxyglucosepositron emission tomographyin the evaluation of the primary tumor in patients withcholangiocarcinoma:a meta-analysis"; World JGastroenterol. 21(40):11481-8, 2015: "Diagnostic accuracyof fluorine-18-fluorodeoxyglucose positron emission tomographyin gallbladder cancer:A meta-analysis"

1.579 /0.348

(BiomedRes Int);

2.369 /0.467

(World JGastroenterol)

App

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Amountawarded


Gianfranco Pesce Ngwa Che Azinwi / Antonella Richetti / Yolanda De Jong / Luca Giovanella /Rolf Wyttenbach

IOSI Radio-Oncology Radioterapia ipofrazionata ad alta conforma-zionalità (IGRT) in pazienti con recidiva bio-chimica di adenocarcinoma della prostata e malattia oligometastatica: studio pilota pro-spettico di fase II (Highly conformational hypo-fractionated radiation therapy (IGRT) in patien-ts with biochemical recurrence of prostate adenocarcinoma and oligometastatic disease: a prospective phase II pilot study)


Carla Pedrazzani Dario Valcarenghi / Monica Bianchi /Christa Pedrazzoli Hutz /Andrea Bordoni

IOSI Nursing Service L'astenia nei pazienti oncologici allo IOSI (Asthe-nia in cancer patients at the IOSI)


Chiara Zecca Claudio Gobbi / Gianna Riccitelli /Alessandro Cianfoni / Emanuele Pravatà


Brain MRI functional connectivity and neurop-sychological assessment in multiple sclerosis patients with migraine


185


Amountawarded


Gianfranco Pesce Ngwa Che Azinwi / Antonella Richetti / Yolanda De Jong / Luca Giovanella /Rolf Wyttenbach

IOSI Radio-Oncology Radioterapia ipofrazionata ad alta conforma-zionalità (IGRT) in pazienti con recidiva bio-chimica di adenocarcinoma della prostata e malattia oligometastatica: studio pilota pro-spettico di fase II (Highly conformational hypo-fractionated radiation therapy (IGRT) in patien-ts with biochemical recurrence of prostate adenocarcinoma and oligometastatic disease: a prospective phase II pilot study)


Carla Pedrazzani Dario Valcarenghi / Monica Bianchi /Christa Pedrazzoli Hutz /Andrea Bordoni

IOSI Nursing Service L'astenia nei pazienti oncologici allo IOSI (Asthe-nia in cancer patients at the IOSI)


Chiara Zecca Claudio Gobbi / Gianna Riccitelli /Alessandro Cianfoni / Emanuele Pravatà


Brain MRI functional connectivity and neurop-sychological assessment in multiple sclerosis patients with migraine


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187

Lead Investigator Other researchers Institute Study titleAmount awarded

in CHFExpected study

duration

Gian Paolo Ramelli Ruben Forni / Saskia Haring-Tosi /Zorica Pervan / Careen van Son /Brigitte Erdmann


Creazione di un registro dei pazienti pediatrici con Paralisi Cerebrale Infantile (PCI) per il Cantone Ticino (Creating a registry of pediatric patients with cerebral palsy - CP - for Ticino Canton)

10,000.– 12 months

Giacomo D. Simonetti Barbara Goeggel Simonetti /Mario G Bianchetti / Gian Paolo Ramelli / Ianira Jelmini


Review sistematica sulla PRES (posterior reversible encephalopathy syndrome) in età pediatrica (Systematic review on PRES - posterior reversible encephalopathy syndrome - in pediatric age)

4,000.– 12 months

Paolo Maino Eva Koetsier / Claudio Gobbi /Alain Kaelin-Lang / Roberto Perez


Dorsal Root Ganglion Stimulation for the Management of Painful In-tractable Small Fibre Neuropathy: A Prospective Case Series

40,777.– 24 months

Pietro-Luca Ratti Alain Kaelin-Lang / Stephany Fulda /Claudio Städler / Salvatore Galati


Sleep and motor improvement in Parkinson's disease at awakening: an observational home-based study ("Sleep Home & Move")

52,000.– 24 months

Giorgia Melli Alain Kaelin-Lang / Paolo Paganetti / Claudio Städler / Salvatore Galati /Flavia Cippà-Pandiani


Alpha synuclein oligomers detection by skin biopsy: a novel early bio-marker for Parkinson disease?

48,620.– 36 months

Monica Taborelli Leonora Chiavari / Eugenia Trotti /Sara Gandini / Silvana Quadrino

CSSI/CCGO Genetic Oncology

Valutazione degli effetti di un intervento di counseling sulla consapevo-lezza del paziente in ambito senologico e oncogenetico (Assessment of the effects of a counseling intervention on patient's awareness in the senology and oncogenetic field)

45,000.– 24 months

Dimitri Christoforidis Davide Zattoni / Fabiano Meroni /Raffaele Rosso

Regional Hospital of Lugano- Surgery

OP-LA study. Ripresa funzionale nei pazienti anziani che si sottopon-gono ad intervento chirurgico per neoplasia del colon-retto (Functio-nal recovery in elderly patients who undergo a surgical operation for colorectal cancer)

37,440.– 24 months

Dario Valcarenghi Carla Pedrazzani / Annamaria Bagnasco / Franco Carnevale

IOSI Nursing Service Le decisioni di assistenza e la valutazione degli esiti per i pazienti in un contesto clinico oncologico (Decisions of assistance and assessment of outcomes for patients in an oncologic clinical setting)

5,000.– 12 months

Giacomo D. Simonetti Maristella Santi / Mario Bianchetti /Sebastiano Lava


Inchiesta sulla prescrizione della vitamina D da parte dei pediatri in Svizzera (Inquiry on the prescription of vitamin D by pediatricians in Switzerland)

7,500.– 14 months

Olivia Pagani Annemarie Fahrländer / Lorenzo Rossi IOSI Oncology Impatto di dieta e digiuno in donne con carcinoma mammario: miglio-ramento della tolleranza ai trattamenti, della qualità di vita e possi-bile impatto sulla prevenzione delle recidive e sulla progressione di malattia (Impact of diet and fasting for women with breast cancer: better tolerance to treatment, quality of life and possible impact on prevention of relapses and disease progression)

32,200.– 36 months

Nicola Grignoli Mattia Lepori / Valentina Di Bernardo / Roberto Malacrida /Roberta Wullschleger / Ilaria Massari / Sara Rubinelli

Rehabilitation Clinic of Novaggio (CRN) La speranza e il privilegio terapeutico nella comunicazione della pro-gnosi (Hope and the therapeutic privilege in prognosis communication)

47,012.50 12 months

Alessandro Cianfoni Lucia Danieli / Daniela Distefano /Elena Prodi / Elisa Ventura /Claudio Gobbi / Gianna Riccitelli /Emanuele Pravatà


Imaging post-contrastografico ad alta risoluzione con Risonanza Ma-gnetica a 3 Tesla: confronto di 3 differenti tecniche (Post-contrast high-resolution imaging with 3 Tesla magnetic resonance imaging: comparison of three different techniques)

56,171.33 18 months

App

endi

ces




duration




10,000.– 12 months




4,000.– 12 months




40,777.– 24 months




52,000.– 24 months




48,620.– 36 months




45,000.– 24 months




37,440.– 24 months



5,000.– 12 months




7,500.– 14 months


32,200.– 36 months



47,012.50 12 months




56,171.33 18 months


187



duration




10,000.– 12 months




4,000.– 12 months




40,777.– 24 months




52,000.– 24 months




48,620.– 36 months




45,000.– 24 months




37,440.– 24 months



5,000.– 12 months




7,500.– 14 months


32,200.– 36 months



47,012.50 12 months




56,171.33 18 months

App

endi

ces

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