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800 employees 5 interna<onal branches 5 produc<on sites worldwide sales in more than 70 countries more than 120 primary patents
FACTS &
FIGURES
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Dedicated areas
Purification
Plantations
GACP
Micropropagation
Pre-clinical
Screening ICH
HACCP
FDA cGMP
OECD
AIFA
Processes
Extraction
Clinical
Products
Biodiversity
Isolation
ANSM
QUALITY,SAFETY
& EFFICACY
RESEARCH
BOTANICALEXPERTISE SCALE UP
& INDUSTRIALPRODUCTION
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ACTIVE PHARMACEUTICAL INGREDIENTS Isolated or semisynthe<c pure products and extracts are produced in compliance with cGMPs and supported by CTD-‐DMFs. Among our main products:
PACLITAXEL Taxus media Rehder -‐ Root, Leaf and Twig -‐ ≥97.0% ≤102.0% by HPLC -‐ An<cancer. 10-‐DAB III Taxus baccata L. -‐ Twig and leaf -‐ ≥96.0% by HPLC -‐ Chemical intermediate. THIOCOLCHICOSIDE Gloriosa superba L. -‐ Seed -‐ ≥98.0% ≤102.0% by poten<ometry -‐ Muscle relaxant. COLCHICINE Gloriosa superba L. -‐ Seed -‐ ≥97.0% ≤102.0% by poten<ometry -‐ An<gout. DOCETAXEL Taxus baccata L. -‐ Twig and leaf -‐ ≥97.0% ≤102.0% by HPLC -‐ An<cancer. MYRTOCYAN® Vaccinium myr6llus L. -‐ Fresh frozen fruit -‐ ≥32.4% ≤39.6% by HPLC -‐ Capillarotropic. ESCIN Aesculus hippocastanum L. -‐ Seed -‐ ≥97.0% ≤103.0% by poten<ometry -‐ An<oedema. GINKGO BILOBA Ginkgo biloba L. -‐ Leaf -‐ ≥22.0% ≤27.0% of flavonoids by HPLC, ≥2.6% ≤3.2% of bilobalide by HPLC, ≥2.8% ≤3.4% of ginkgolides A,B,C by HPLC, ≤5 ppm of ginkgolic acids by HPLC -‐ Blood circula<on improver.
HEALTH-‐FOOD INGREDIENTS Indena leverages its solid pharmaceu<cal background for the health-‐food field, developing biologically ac<ve ingredients for supplements, func<onal, medical and baby food products for more than 40 years. These include:
MIRTOSELECT® Vaccinium myr6llus L. -‐ Fresh frozen fruit -‐ ≥36.0% of anthocyanins by HPLC -‐ ≥25.0% anthocyanins as anthocyanidins by spectrophotometry -‐ Eye health, Circulatory health, An<oxidant ac<vity. LEUCOSELECT® Vi6s vinifera L. -‐ Seed -‐ ≥95.0% ≤105.0% of proanthocyanidins by GPC, ≥13.0% ≤19.0% of catechin and epicatechin by HPLC -‐ An<oxidant ac<vity, Circulatory health. GREENSELECT® Camellia sinensis (L.) O. Kuntze -‐ Young leaf -‐ ≥60.0% of total polyphenols, ≥40.0% of (-‐)-‐epigallocatechin-‐3-‐O-‐gallate, ≤0.1% of caffeine by HPLC -‐ An<oxidant ac<vity. OPEXTAN® Olea europaea L. -‐ Fruit -‐ ≥10.0% of total polyphenols by spectrophotometry, ≥2.0% ≤3.5% of verbascoside by HPLC, ≥4.5% of hydroxytyrosol and its deriva<ves by HPLC -‐ An<oxidant ac<vity, Healthy skin, Healthy cardiovascular func<on. BEANBLOCK® Phaseolus vulgaris L. -‐ Common bean -‐ ≥6.0% as alpha amylase inhibitor by HPLC 1,100 U/mg of alpha amylase inhibi<ng ac<vity, 30,000 HAU/g of hemagglu<na<ng ac<vity by spectroph./enzym. -‐ Appe<te regulator, Healthy blood sugar metabolism.
PERSONAL CARE INGREDIENTS Indena develops func<onal ingredients with a wide range of applica<ons for “high” skin & hair care products, including:
ESCIN Aesculus hippocastanum L. -‐ Seed -‐-‐ ≥97.0% ≤103.0% by poten<ometry -‐ Capillarotropic. CENTELLA ASIATICA TRITERPENES Centella asia6ca (L.) Urban -‐ Leaf -‐ ≥36.0% ≤44.0% of asia<coside, ≥56.0% ≤64.0% of genins as sum of asia<c acid and madecassic acid by HPLC -‐ An<-‐wrinkles, Stretchmarks improver. RUSCOGENINS Ruscus aculeatus L. -‐ Rhizome and root -‐ ≥92.0% ≤103.0% of ruscogenins, ≥60.0% ≤80% of neoruscogenin, ≥20.0% ≤40.0% of ruscogenin by HPLC An<cellulite, Vasoprotectant.
CURBILENE® Cucurbita pepo L. -‐ Naked seed -‐ ≥85.0% of faPy acids by GC -‐ Skin maqng agent. ZANTHALENE® Zanthoxylum bungeanum Maxim. -‐ Pericarp -‐ ≥4.4% ≤6.4% of alkylamides by HPLC -‐ An<-‐itching, Skin sensi<vity modulator.
XILOGEL® Tamarindus indica L. -‐ Seed -‐ ≥85.0% by HPLC -‐ Moisturizer, Skin restructurant, An<-‐wrinkles. CENTEVITA® Centella asia<ca (L.) Urban -‐ Leaf -‐ ≥45.0% of the sum of asia<coside, madecassoside, asia<c and madecassic acids by HPLC -‐ Collagen restructurant and an<-‐glyca<on agent.
BOSEXIL® Boswellia serrata Roxb. ex Colebr. -‐ Resin -‐ ≥25.0% boswellic acids by HPLC -‐ Soothing, An<-‐photo ageing.
PHYTOSOME® MORE BIOAVAILABLE Indena has developed a proprietary technology to op<mise the bioavailability of selected phytochemicals. Products include:
CASPEROME® Boswellia serrata Roxb. ex Colebr. -‐ Resin -‐ ≥25.0% boswellic acids by HPLC -‐ For healthy inflammatory response. MERIVA® Curcuma longa L. -‐ Rhizome -‐ ≥18.0% ≤22.0% of curcuminoids by HPLC -‐ Joint health, For healthy inflammatory response. SILIPHOS® Silybum marianum L. Gaertn. -‐ Fruit -‐ ≥29.7% ≤36.3% of silybin by HPLC -‐ Healthy liver. GREENSELECT® Camellia sinensis (L.) O. Kuntze -‐ Young leaf -‐ ≥19.0% ≤25.0% of polyphenols expressed as (-‐)-‐epigallocatechin-‐3-‐O-‐gallate, ≥13.0% of (-‐)-‐epigallocatechin-‐3-‐O-‐gallate, ≤0.1% of caffeine by HPLC -‐ An<oxidant, Weight loss agent. LEUCOSELECT® Vi6s vinifera L. -‐ Seed -‐ ≥25.0% ≤30.0% of proanthocyanidins by GPC -‐ Cardiovascular protectant, UV protectant, An<oxidant. GINKGOSELECT® Ginkgo biloba L. -‐ Leaf -‐ ≥7.0% of ginkgoflavonglucosides, ≥2.0% of ginkgoterpenes, ≥0.8% of bilobalide, ≥0.8% of ginkgolides by HPLC ≤5 ppm of total ginkgolic acids by HPLC -‐ Cogni<on and circula<on improver, An<oxidant, Vasokine<c.
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