Baran et al. Supplement

1

Increased Thalamocortical Connectivity in Schizophrenia Correlates With Sleep Spindle Deficits: Evidence for a Common Pathophysiology

Supplementary Information

Table S1. Daily medication dose in the schizophrenia group. Each row corresponds to a participant.

Antipsychotic Antidepressant Benzodiazepine Other

Aripiprazole (3.5 mg) Valproic acid (250 mg)

Clozapine (100 mg) Clomipramine (150 mg) Valproic acid (1250 mg)

Clozapine (200 mg)

Clozapine (300 mg)

Clozapine (300 mg) Bupropion (150 mg)

Clozaril (100 mg) Haloperidol 1 mg); Olanzapine (20 mg) Citalopram (30 mg)

Olanzapine (10 mg)

Olanzapine (10 mg) Sertraline 125 mg)

Olanzapine (10 mg) Sertraline (200 mg)

Olanzapine (15 mg) Lorazepam (0.5 mg)

Olanzapine (15 mg) Sertraline (100 mg) Lamotrigine (200 mg) Olanzapine (5 mg); Clozapine (200 mg) Citalopram (20 mg) Paliperidone sustenna (234 mg monthly); Clozapine (12.5 mg) Paliperidone sustenna (234 mg monthly)

Perphenazine (24 mg)

Perphenazine (6 mg) Lamotrigine (200 mg)

Quetiapine (400 mg) Sertraline (150 mg)

Quetiapine (400 mg) Lorazepam (0.5 mg) Benztropine (1 mg)

Quetiapine (450 mg) Fluoxetine (80 mg) Risperidone (3 mg) Olanzapine (20 mg)

Risperidone (2 mg) Lamotrigine (300 mg)

Risperidone 2 mg)

Ziprasidone (80 mg)

Baran et al. Supplement

2

Figure S1. Bilateral whole thalamus seed region (28,580 mm3) as defined using the probabilistic FSL Oxford thalamic connectivity atlas with a threshold of 25 (1,2). The thalamus seed region (in red) is displayed on the MNI template brain.

R L

Baran et al. Supplement

3

Figure S2. Unthresholded statistical maps of thalamocortical functional connectivity displayed on the template brain. (A) Healthy control group; (B) Schizophrenia group. Positive connectivity is depicted in warm colors; negative connectivity is blue.

Baran et al. Supplement

4

Supplemental References

1. Behrens TE, Johansen-Berg H, Woolrich MW, Smith SM, Wheeler-Kingshott CA, Boulby PA, Barker GJ, Sillery EL, Sheehan K, Ciccarelli O, Thompson AJ, Brady JM, Matthews PM. Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nat Neurosci. 2003;6:750-757.

2. Behrens TE, Woolrich MW, Jenkinson M, Johansen-Berg H, Nunes RG, Clare S, Matthews PM, Brady JM, Smith SM. Characterization and propagation of uncertainty in diffusion-weighted MR imaging. Magn Reson Med. 2003;50:1077-1088.