incf 2013 - uniform resource layer

27
Uniform Resource Layer Anita Bandrowski, Ph. D. Neuroscience Information Framework University of California, San Diego

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Anita Bandrowski explains how the uniform resource layer of the Neuroscience Information Framework allows several interesting questions about the state of scientific research to be answered.

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Page 1: INCF 2013 - Uniform Resource Layer

Uniform Resource Layer

Anita Bandrowski Ph DNeuroscience Information Framework

University of California San Diego

Cataloging Biological Resources

httpneuinfoorg

Databases Tissue banksSoftware toolsServices

A resource catalogbull Must have a reasonable account of what is out there

httpneuinfoorg

Image repository

Database

Atlas

NITRC

Harvard

Nencki Inst

How are resources added to the registry

Curators Assign structured metadata to each entry

the metadata is based on a harmonized resource

type ontology

Can we mine relationships between resources

httpneuinfoorg

Human annotations give a different graph

of relationships

Text mining gives a

picture of the most

used resources

PDB

A shared resource registry

httpneuinfoorg

NIF

Social Network of Resources

bull 3DVC ndash 182

bull Force11 ndash 88

bull Monarch ndash 88

bull OneMind ndash 609

bull GeneOntology Tools - 140

1

6

1

2

12

6

Which resources are

shared by multiple

communities

Structured data allows us to answer questions easily

httpneurolexorg

How do you keep a registry current

httpneuinfoorg

BUT DATABASES CAN HAVE NEW DATA EVERY DAY

Each resource implements a different model which works well for the resource

Connectome databases

httpneuinfoorg

Uniform resource layer also meansuniform data access

httpneuinfoorg

Luis Marenco Rixin Wang Yale

gt200 data sourcesgt390M data records

gt15M links to Articles

Data are divided into types

httpneuinfoorg

Uniform search

httpneuinfoorg

Data about the subthalamus

httpneuinfoorg

The Brain and itsrsquo data

Ontologies provide a semantic framework for understanding dataresource landscape

Data sources included in NIF-Complete list httpdisconeuinfoorg-Services httpneuinfoorgdevelopersStriatum

HypothalamusOlfactory bulb

Cerebral cortex

Brain

Bra

in r

egio

n

Data source

VadimAstakhov Kepler Workflow Engine

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

GR

ID

Bio

Nu

mb

ers

Bra

inIn

fo

Bra

inSp

an1

Bra

inSp

an3

BR

EDE

Cel

lImag

eLib

rary

Cer

ebel

lar

Pla

tfo

rm

Ch

emo

rece

pto

rs

Co

riel

lTis

sue

CTD

Dru

g R

elat

ed G

ene

Dat

abas

e

EAM

Ense

mb

lHu

man

Epig

eno

mic

s P

roje

ct

Gem

ma

GEN

SAT

Gra

nts

go

v

Hea

lth

Dat

a

HP

O A

nn

ota

tio

ns

IBV

D

Lab

fo

r V

isu

al N

euro

scie

nce

MG

ITra

nsg

enes

Mo

nar

ch

Nat

ion

al M

ou

se M

etab

olic

Ph

eno

typ

ing hellip

Neu

rod

atab

ase

Neu

rofe

d

Neu

ron

DB

NIF

Inte

grat

ed A

nim

als

NIF

Inte

grat

ed C

ell L

ines

NIF

Inte

grat

ed D

isea

se

NIF

Inte

grat

ed N

SC

NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

s

NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 2: INCF 2013 - Uniform Resource Layer

Cataloging Biological Resources

httpneuinfoorg

Databases Tissue banksSoftware toolsServices

A resource catalogbull Must have a reasonable account of what is out there

httpneuinfoorg

Image repository

Database

Atlas

NITRC

Harvard

Nencki Inst

How are resources added to the registry

Curators Assign structured metadata to each entry

the metadata is based on a harmonized resource

type ontology

Can we mine relationships between resources

httpneuinfoorg

Human annotations give a different graph

of relationships

Text mining gives a

picture of the most

used resources

PDB

A shared resource registry

httpneuinfoorg

NIF

Social Network of Resources

bull 3DVC ndash 182

bull Force11 ndash 88

bull Monarch ndash 88

bull OneMind ndash 609

bull GeneOntology Tools - 140

1

6

1

2

12

6

Which resources are

shared by multiple

communities

Structured data allows us to answer questions easily

httpneurolexorg

How do you keep a registry current

httpneuinfoorg

BUT DATABASES CAN HAVE NEW DATA EVERY DAY

Each resource implements a different model which works well for the resource

Connectome databases

httpneuinfoorg

Uniform resource layer also meansuniform data access

httpneuinfoorg

Luis Marenco Rixin Wang Yale

gt200 data sourcesgt390M data records

gt15M links to Articles

Data are divided into types

httpneuinfoorg

Uniform search

httpneuinfoorg

Data about the subthalamus

httpneuinfoorg

The Brain and itsrsquo data

Ontologies provide a semantic framework for understanding dataresource landscape

Data sources included in NIF-Complete list httpdisconeuinfoorg-Services httpneuinfoorgdevelopersStriatum

HypothalamusOlfactory bulb

Cerebral cortex

Brain

Bra

in r

egio

n

Data source

VadimAstakhov Kepler Workflow Engine

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

GR

ID

Bio

Nu

mb

ers

Bra

inIn

fo

Bra

inSp

an1

Bra

inSp

an3

BR

EDE

Cel

lImag

eLib

rary

Cer

ebel

lar

Pla

tfo

rm

Ch

emo

rece

pto

rs

Co

riel

lTis

sue

CTD

Dru

g R

elat

ed G

ene

Dat

abas

e

EAM

Ense

mb

lHu

man

Epig

eno

mic

s P

roje

ct

Gem

ma

GEN

SAT

Gra

nts

go

v

Hea

lth

Dat

a

HP

O A

nn

ota

tio

ns

IBV

D

Lab

fo

r V

isu

al N

euro

scie

nce

MG

ITra

nsg

enes

Mo

nar

ch

Nat

ion

al M

ou

se M

etab

olic

Ph

eno

typ

ing hellip

Neu

rod

atab

ase

Neu

rofe

d

Neu

ron

DB

NIF

Inte

grat

ed A

nim

als

NIF

Inte

grat

ed C

ell L

ines

NIF

Inte

grat

ed D

isea

se

NIF

Inte

grat

ed N

SC

NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

s

NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 3: INCF 2013 - Uniform Resource Layer

A resource catalogbull Must have a reasonable account of what is out there

httpneuinfoorg

Image repository

Database

Atlas

NITRC

Harvard

Nencki Inst

How are resources added to the registry

Curators Assign structured metadata to each entry

the metadata is based on a harmonized resource

type ontology

Can we mine relationships between resources

httpneuinfoorg

Human annotations give a different graph

of relationships

Text mining gives a

picture of the most

used resources

PDB

A shared resource registry

httpneuinfoorg

NIF

Social Network of Resources

bull 3DVC ndash 182

bull Force11 ndash 88

bull Monarch ndash 88

bull OneMind ndash 609

bull GeneOntology Tools - 140

1

6

1

2

12

6

Which resources are

shared by multiple

communities

Structured data allows us to answer questions easily

httpneurolexorg

How do you keep a registry current

httpneuinfoorg

BUT DATABASES CAN HAVE NEW DATA EVERY DAY

Each resource implements a different model which works well for the resource

Connectome databases

httpneuinfoorg

Uniform resource layer also meansuniform data access

httpneuinfoorg

Luis Marenco Rixin Wang Yale

gt200 data sourcesgt390M data records

gt15M links to Articles

Data are divided into types

httpneuinfoorg

Uniform search

httpneuinfoorg

Data about the subthalamus

httpneuinfoorg

The Brain and itsrsquo data

Ontologies provide a semantic framework for understanding dataresource landscape

Data sources included in NIF-Complete list httpdisconeuinfoorg-Services httpneuinfoorgdevelopersStriatum

HypothalamusOlfactory bulb

Cerebral cortex

Brain

Bra

in r

egio

n

Data source

VadimAstakhov Kepler Workflow Engine

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

GR

ID

Bio

Nu

mb

ers

Bra

inIn

fo

Bra

inSp

an1

Bra

inSp

an3

BR

EDE

Cel

lImag

eLib

rary

Cer

ebel

lar

Pla

tfo

rm

Ch

emo

rece

pto

rs

Co

riel

lTis

sue

CTD

Dru

g R

elat

ed G

ene

Dat

abas

e

EAM

Ense

mb

lHu

man

Epig

eno

mic

s P

roje

ct

Gem

ma

GEN

SAT

Gra

nts

go

v

Hea

lth

Dat

a

HP

O A

nn

ota

tio

ns

IBV

D

Lab

fo

r V

isu

al N

euro

scie

nce

MG

ITra

nsg

enes

Mo

nar

ch

Nat

ion

al M

ou

se M

etab

olic

Ph

eno

typ

ing hellip

Neu

rod

atab

ase

Neu

rofe

d

Neu

ron

DB

NIF

Inte

grat

ed A

nim

als

NIF

Inte

grat

ed C

ell L

ines

NIF

Inte

grat

ed D

isea

se

NIF

Inte

grat

ed N

SC

NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

s

NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 4: INCF 2013 - Uniform Resource Layer

How are resources added to the registry

Curators Assign structured metadata to each entry

the metadata is based on a harmonized resource

type ontology

Can we mine relationships between resources

httpneuinfoorg

Human annotations give a different graph

of relationships

Text mining gives a

picture of the most

used resources

PDB

A shared resource registry

httpneuinfoorg

NIF

Social Network of Resources

bull 3DVC ndash 182

bull Force11 ndash 88

bull Monarch ndash 88

bull OneMind ndash 609

bull GeneOntology Tools - 140

1

6

1

2

12

6

Which resources are

shared by multiple

communities

Structured data allows us to answer questions easily

httpneurolexorg

How do you keep a registry current

httpneuinfoorg

BUT DATABASES CAN HAVE NEW DATA EVERY DAY

Each resource implements a different model which works well for the resource

Connectome databases

httpneuinfoorg

Uniform resource layer also meansuniform data access

httpneuinfoorg

Luis Marenco Rixin Wang Yale

gt200 data sourcesgt390M data records

gt15M links to Articles

Data are divided into types

httpneuinfoorg

Uniform search

httpneuinfoorg

Data about the subthalamus

httpneuinfoorg

The Brain and itsrsquo data

Ontologies provide a semantic framework for understanding dataresource landscape

Data sources included in NIF-Complete list httpdisconeuinfoorg-Services httpneuinfoorgdevelopersStriatum

HypothalamusOlfactory bulb

Cerebral cortex

Brain

Bra

in r

egio

n

Data source

VadimAstakhov Kepler Workflow Engine

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

GR

ID

Bio

Nu

mb

ers

Bra

inIn

fo

Bra

inSp

an1

Bra

inSp

an3

BR

EDE

Cel

lImag

eLib

rary

Cer

ebel

lar

Pla

tfo

rm

Ch

emo

rece

pto

rs

Co

riel

lTis

sue

CTD

Dru

g R

elat

ed G

ene

Dat

abas

e

EAM

Ense

mb

lHu

man

Epig

eno

mic

s P

roje

ct

Gem

ma

GEN

SAT

Gra

nts

go

v

Hea

lth

Dat

a

HP

O A

nn

ota

tio

ns

IBV

D

Lab

fo

r V

isu

al N

euro

scie

nce

MG

ITra

nsg

enes

Mo

nar

ch

Nat

ion

al M

ou

se M

etab

olic

Ph

eno

typ

ing hellip

Neu

rod

atab

ase

Neu

rofe

d

Neu

ron

DB

NIF

Inte

grat

ed A

nim

als

NIF

Inte

grat

ed C

ell L

ines

NIF

Inte

grat

ed D

isea

se

NIF

Inte

grat

ed N

SC

NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

s

NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 5: INCF 2013 - Uniform Resource Layer

Can we mine relationships between resources

httpneuinfoorg

Human annotations give a different graph

of relationships

Text mining gives a

picture of the most

used resources

PDB

A shared resource registry

httpneuinfoorg

NIF

Social Network of Resources

bull 3DVC ndash 182

bull Force11 ndash 88

bull Monarch ndash 88

bull OneMind ndash 609

bull GeneOntology Tools - 140

1

6

1

2

12

6

Which resources are

shared by multiple

communities

Structured data allows us to answer questions easily

httpneurolexorg

How do you keep a registry current

httpneuinfoorg

BUT DATABASES CAN HAVE NEW DATA EVERY DAY

Each resource implements a different model which works well for the resource

Connectome databases

httpneuinfoorg

Uniform resource layer also meansuniform data access

httpneuinfoorg

Luis Marenco Rixin Wang Yale

gt200 data sourcesgt390M data records

gt15M links to Articles

Data are divided into types

httpneuinfoorg

Uniform search

httpneuinfoorg

Data about the subthalamus

httpneuinfoorg

The Brain and itsrsquo data

Ontologies provide a semantic framework for understanding dataresource landscape

Data sources included in NIF-Complete list httpdisconeuinfoorg-Services httpneuinfoorgdevelopersStriatum

HypothalamusOlfactory bulb

Cerebral cortex

Brain

Bra

in r

egio

n

Data source

VadimAstakhov Kepler Workflow Engine

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

GR

ID

Bio

Nu

mb

ers

Bra

inIn

fo

Bra

inSp

an1

Bra

inSp

an3

BR

EDE

Cel

lImag

eLib

rary

Cer

ebel

lar

Pla

tfo

rm

Ch

emo

rece

pto

rs

Co

riel

lTis

sue

CTD

Dru

g R

elat

ed G

ene

Dat

abas

e

EAM

Ense

mb

lHu

man

Epig

eno

mic

s P

roje

ct

Gem

ma

GEN

SAT

Gra

nts

go

v

Hea

lth

Dat

a

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O A

nn

ota

tio

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IBV

D

Lab

fo

r V

isu

al N

euro

scie

nce

MG

ITra

nsg

enes

Mo

nar

ch

Nat

ion

al M

ou

se M

etab

olic

Ph

eno

typ

ing hellip

Neu

rod

atab

ase

Neu

rofe

d

Neu

ron

DB

NIF

Inte

grat

ed A

nim

als

NIF

Inte

grat

ed C

ell L

ines

NIF

Inte

grat

ed D

isea

se

NIF

Inte

grat

ed N

SC

NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

s

NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 6: INCF 2013 - Uniform Resource Layer

A shared resource registry

httpneuinfoorg

NIF

Social Network of Resources

bull 3DVC ndash 182

bull Force11 ndash 88

bull Monarch ndash 88

bull OneMind ndash 609

bull GeneOntology Tools - 140

1

6

1

2

12

6

Which resources are

shared by multiple

communities

Structured data allows us to answer questions easily

httpneurolexorg

How do you keep a registry current

httpneuinfoorg

BUT DATABASES CAN HAVE NEW DATA EVERY DAY

Each resource implements a different model which works well for the resource

Connectome databases

httpneuinfoorg

Uniform resource layer also meansuniform data access

httpneuinfoorg

Luis Marenco Rixin Wang Yale

gt200 data sourcesgt390M data records

gt15M links to Articles

Data are divided into types

httpneuinfoorg

Uniform search

httpneuinfoorg

Data about the subthalamus

httpneuinfoorg

The Brain and itsrsquo data

Ontologies provide a semantic framework for understanding dataresource landscape

Data sources included in NIF-Complete list httpdisconeuinfoorg-Services httpneuinfoorgdevelopersStriatum

HypothalamusOlfactory bulb

Cerebral cortex

Brain

Bra

in r

egio

n

Data source

VadimAstakhov Kepler Workflow Engine

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

GR

ID

Bio

Nu

mb

ers

Bra

inIn

fo

Bra

inSp

an1

Bra

inSp

an3

BR

EDE

Cel

lImag

eLib

rary

Cer

ebel

lar

Pla

tfo

rm

Ch

emo

rece

pto

rs

Co

riel

lTis

sue

CTD

Dru

g R

elat

ed G

ene

Dat

abas

e

EAM

Ense

mb

lHu

man

Epig

eno

mic

s P

roje

ct

Gem

ma

GEN

SAT

Gra

nts

go

v

Hea

lth

Dat

a

HP

O A

nn

ota

tio

ns

IBV

D

Lab

fo

r V

isu

al N

euro

scie

nce

MG

ITra

nsg

enes

Mo

nar

ch

Nat

ion

al M

ou

se M

etab

olic

Ph

eno

typ

ing hellip

Neu

rod

atab

ase

Neu

rofe

d

Neu

ron

DB

NIF

Inte

grat

ed A

nim

als

NIF

Inte

grat

ed C

ell L

ines

NIF

Inte

grat

ed D

isea

se

NIF

Inte

grat

ed N

SC

NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

s

NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 7: INCF 2013 - Uniform Resource Layer

Social Network of Resources

bull 3DVC ndash 182

bull Force11 ndash 88

bull Monarch ndash 88

bull OneMind ndash 609

bull GeneOntology Tools - 140

1

6

1

2

12

6

Which resources are

shared by multiple

communities

Structured data allows us to answer questions easily

httpneurolexorg

How do you keep a registry current

httpneuinfoorg

BUT DATABASES CAN HAVE NEW DATA EVERY DAY

Each resource implements a different model which works well for the resource

Connectome databases

httpneuinfoorg

Uniform resource layer also meansuniform data access

httpneuinfoorg

Luis Marenco Rixin Wang Yale

gt200 data sourcesgt390M data records

gt15M links to Articles

Data are divided into types

httpneuinfoorg

Uniform search

httpneuinfoorg

Data about the subthalamus

httpneuinfoorg

The Brain and itsrsquo data

Ontologies provide a semantic framework for understanding dataresource landscape

Data sources included in NIF-Complete list httpdisconeuinfoorg-Services httpneuinfoorgdevelopersStriatum

HypothalamusOlfactory bulb

Cerebral cortex

Brain

Bra

in r

egio

n

Data source

VadimAstakhov Kepler Workflow Engine

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

GR

ID

Bio

Nu

mb

ers

Bra

inIn

fo

Bra

inSp

an1

Bra

inSp

an3

BR

EDE

Cel

lImag

eLib

rary

Cer

ebel

lar

Pla

tfo

rm

Ch

emo

rece

pto

rs

Co

riel

lTis

sue

CTD

Dru

g R

elat

ed G

ene

Dat

abas

e

EAM

Ense

mb

lHu

man

Epig

eno

mic

s P

roje

ct

Gem

ma

GEN

SAT

Gra

nts

go

v

Hea

lth

Dat

a

HP

O A

nn

ota

tio

ns

IBV

D

Lab

fo

r V

isu

al N

euro

scie

nce

MG

ITra

nsg

enes

Mo

nar

ch

Nat

ion

al M

ou

se M

etab

olic

Ph

eno

typ

ing hellip

Neu

rod

atab

ase

Neu

rofe

d

Neu

ron

DB

NIF

Inte

grat

ed A

nim

als

NIF

Inte

grat

ed C

ell L

ines

NIF

Inte

grat

ed D

isea

se

NIF

Inte

grat

ed N

SC

NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

s

NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 8: INCF 2013 - Uniform Resource Layer

How do you keep a registry current

httpneuinfoorg

BUT DATABASES CAN HAVE NEW DATA EVERY DAY

Each resource implements a different model which works well for the resource

Connectome databases

httpneuinfoorg

Uniform resource layer also meansuniform data access

httpneuinfoorg

Luis Marenco Rixin Wang Yale

gt200 data sourcesgt390M data records

gt15M links to Articles

Data are divided into types

httpneuinfoorg

Uniform search

httpneuinfoorg

Data about the subthalamus

httpneuinfoorg

The Brain and itsrsquo data

Ontologies provide a semantic framework for understanding dataresource landscape

Data sources included in NIF-Complete list httpdisconeuinfoorg-Services httpneuinfoorgdevelopersStriatum

HypothalamusOlfactory bulb

Cerebral cortex

Brain

Bra

in r

egio

n

Data source

VadimAstakhov Kepler Workflow Engine

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

GR

ID

Bio

Nu

mb

ers

Bra

inIn

fo

Bra

inSp

an1

Bra

inSp

an3

BR

EDE

Cel

lImag

eLib

rary

Cer

ebel

lar

Pla

tfo

rm

Ch

emo

rece

pto

rs

Co

riel

lTis

sue

CTD

Dru

g R

elat

ed G

ene

Dat

abas

e

EAM

Ense

mb

lHu

man

Epig

eno

mic

s P

roje

ct

Gem

ma

GEN

SAT

Gra

nts

go

v

Hea

lth

Dat

a

HP

O A

nn

ota

tio

ns

IBV

D

Lab

fo

r V

isu

al N

euro

scie

nce

MG

ITra

nsg

enes

Mo

nar

ch

Nat

ion

al M

ou

se M

etab

olic

Ph

eno

typ

ing hellip

Neu

rod

atab

ase

Neu

rofe

d

Neu

ron

DB

NIF

Inte

grat

ed A

nim

als

NIF

Inte

grat

ed C

ell L

ines

NIF

Inte

grat

ed D

isea

se

NIF

Inte

grat

ed N

SC

NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

s

NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 9: INCF 2013 - Uniform Resource Layer

BUT DATABASES CAN HAVE NEW DATA EVERY DAY

Each resource implements a different model which works well for the resource

Connectome databases

httpneuinfoorg

Uniform resource layer also meansuniform data access

httpneuinfoorg

Luis Marenco Rixin Wang Yale

gt200 data sourcesgt390M data records

gt15M links to Articles

Data are divided into types

httpneuinfoorg

Uniform search

httpneuinfoorg

Data about the subthalamus

httpneuinfoorg

The Brain and itsrsquo data

Ontologies provide a semantic framework for understanding dataresource landscape

Data sources included in NIF-Complete list httpdisconeuinfoorg-Services httpneuinfoorgdevelopersStriatum

HypothalamusOlfactory bulb

Cerebral cortex

Brain

Bra

in r

egio

n

Data source

VadimAstakhov Kepler Workflow Engine

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

GR

ID

Bio

Nu

mb

ers

Bra

inIn

fo

Bra

inSp

an1

Bra

inSp

an3

BR

EDE

Cel

lImag

eLib

rary

Cer

ebel

lar

Pla

tfo

rm

Ch

emo

rece

pto

rs

Co

riel

lTis

sue

CTD

Dru

g R

elat

ed G

ene

Dat

abas

e

EAM

Ense

mb

lHu

man

Epig

eno

mic

s P

roje

ct

Gem

ma

GEN

SAT

Gra

nts

go

v

Hea

lth

Dat

a

HP

O A

nn

ota

tio

ns

IBV

D

Lab

fo

r V

isu

al N

euro

scie

nce

MG

ITra

nsg

enes

Mo

nar

ch

Nat

ion

al M

ou

se M

etab

olic

Ph

eno

typ

ing hellip

Neu

rod

atab

ase

Neu

rofe

d

Neu

ron

DB

NIF

Inte

grat

ed A

nim

als

NIF

Inte

grat

ed C

ell L

ines

NIF

Inte

grat

ed D

isea

se

NIF

Inte

grat

ed N

SC

NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

s

NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 10: INCF 2013 - Uniform Resource Layer

Each resource implements a different model which works well for the resource

Connectome databases

httpneuinfoorg

Uniform resource layer also meansuniform data access

httpneuinfoorg

Luis Marenco Rixin Wang Yale

gt200 data sourcesgt390M data records

gt15M links to Articles

Data are divided into types

httpneuinfoorg

Uniform search

httpneuinfoorg

Data about the subthalamus

httpneuinfoorg

The Brain and itsrsquo data

Ontologies provide a semantic framework for understanding dataresource landscape

Data sources included in NIF-Complete list httpdisconeuinfoorg-Services httpneuinfoorgdevelopersStriatum

HypothalamusOlfactory bulb

Cerebral cortex

Brain

Bra

in r

egio

n

Data source

VadimAstakhov Kepler Workflow Engine

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

GR

ID

Bio

Nu

mb

ers

Bra

inIn

fo

Bra

inSp

an1

Bra

inSp

an3

BR

EDE

Cel

lImag

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rary

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ebel

lar

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Ch

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riel

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sue

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g R

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man

Epig

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ct

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ma

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Dat

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D

Lab

fo

r V

isu

al N

euro

scie

nce

MG

ITra

nsg

enes

Mo

nar

ch

Nat

ion

al M

ou

se M

etab

olic

Ph

eno

typ

ing hellip

Neu

rod

atab

ase

Neu

rofe

d

Neu

ron

DB

NIF

Inte

grat

ed A

nim

als

NIF

Inte

grat

ed C

ell L

ines

NIF

Inte

grat

ed D

isea

se

NIF

Inte

grat

ed N

SC

NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

s

NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 11: INCF 2013 - Uniform Resource Layer

Uniform resource layer also meansuniform data access

httpneuinfoorg

Luis Marenco Rixin Wang Yale

gt200 data sourcesgt390M data records

gt15M links to Articles

Data are divided into types

httpneuinfoorg

Uniform search

httpneuinfoorg

Data about the subthalamus

httpneuinfoorg

The Brain and itsrsquo data

Ontologies provide a semantic framework for understanding dataresource landscape

Data sources included in NIF-Complete list httpdisconeuinfoorg-Services httpneuinfoorgdevelopersStriatum

HypothalamusOlfactory bulb

Cerebral cortex

Brain

Bra

in r

egio

n

Data source

VadimAstakhov Kepler Workflow Engine

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

GR

ID

Bio

Nu

mb

ers

Bra

inIn

fo

Bra

inSp

an1

Bra

inSp

an3

BR

EDE

Cel

lImag

eLib

rary

Cer

ebel

lar

Pla

tfo

rm

Ch

emo

rece

pto

rs

Co

riel

lTis

sue

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Dru

g R

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ed G

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Dat

abas

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Ense

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man

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ct

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ma

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Gra

nts

go

v

Hea

lth

Dat

a

HP

O A

nn

ota

tio

ns

IBV

D

Lab

fo

r V

isu

al N

euro

scie

nce

MG

ITra

nsg

enes

Mo

nar

ch

Nat

ion

al M

ou

se M

etab

olic

Ph

eno

typ

ing hellip

Neu

rod

atab

ase

Neu

rofe

d

Neu

ron

DB

NIF

Inte

grat

ed A

nim

als

NIF

Inte

grat

ed C

ell L

ines

NIF

Inte

grat

ed D

isea

se

NIF

Inte

grat

ed N

SC

NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

s

NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 12: INCF 2013 - Uniform Resource Layer

gt200 data sourcesgt390M data records

gt15M links to Articles

Data are divided into types

httpneuinfoorg

Uniform search

httpneuinfoorg

Data about the subthalamus

httpneuinfoorg

The Brain and itsrsquo data

Ontologies provide a semantic framework for understanding dataresource landscape

Data sources included in NIF-Complete list httpdisconeuinfoorg-Services httpneuinfoorgdevelopersStriatum

HypothalamusOlfactory bulb

Cerebral cortex

Brain

Bra

in r

egio

n

Data source

VadimAstakhov Kepler Workflow Engine

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

GR

ID

Bio

Nu

mb

ers

Bra

inIn

fo

Bra

inSp

an1

Bra

inSp

an3

BR

EDE

Cel

lImag

eLib

rary

Cer

ebel

lar

Pla

tfo

rm

Ch

emo

rece

pto

rs

Co

riel

lTis

sue

CTD

Dru

g R

elat

ed G

ene

Dat

abas

e

EAM

Ense

mb

lHu

man

Epig

eno

mic

s P

roje

ct

Gem

ma

GEN

SAT

Gra

nts

go

v

Hea

lth

Dat

a

HP

O A

nn

ota

tio

ns

IBV

D

Lab

fo

r V

isu

al N

euro

scie

nce

MG

ITra

nsg

enes

Mo

nar

ch

Nat

ion

al M

ou

se M

etab

olic

Ph

eno

typ

ing hellip

Neu

rod

atab

ase

Neu

rofe

d

Neu

ron

DB

NIF

Inte

grat

ed A

nim

als

NIF

Inte

grat

ed C

ell L

ines

NIF

Inte

grat

ed D

isea

se

NIF

Inte

grat

ed N

SC

NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

s

NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 13: INCF 2013 - Uniform Resource Layer

Data are divided into types

httpneuinfoorg

Uniform search

httpneuinfoorg

Data about the subthalamus

httpneuinfoorg

The Brain and itsrsquo data

Ontologies provide a semantic framework for understanding dataresource landscape

Data sources included in NIF-Complete list httpdisconeuinfoorg-Services httpneuinfoorgdevelopersStriatum

HypothalamusOlfactory bulb

Cerebral cortex

Brain

Bra

in r

egio

n

Data source

VadimAstakhov Kepler Workflow Engine

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

GR

ID

Bio

Nu

mb

ers

Bra

inIn

fo

Bra

inSp

an1

Bra

inSp

an3

BR

EDE

Cel

lImag

eLib

rary

Cer

ebel

lar

Pla

tfo

rm

Ch

emo

rece

pto

rs

Co

riel

lTis

sue

CTD

Dru

g R

elat

ed G

ene

Dat

abas

e

EAM

Ense

mb

lHu

man

Epig

eno

mic

s P

roje

ct

Gem

ma

GEN

SAT

Gra

nts

go

v

Hea

lth

Dat

a

HP

O A

nn

ota

tio

ns

IBV

D

Lab

fo

r V

isu

al N

euro

scie

nce

MG

ITra

nsg

enes

Mo

nar

ch

Nat

ion

al M

ou

se M

etab

olic

Ph

eno

typ

ing hellip

Neu

rod

atab

ase

Neu

rofe

d

Neu

ron

DB

NIF

Inte

grat

ed A

nim

als

NIF

Inte

grat

ed C

ell L

ines

NIF

Inte

grat

ed D

isea

se

NIF

Inte

grat

ed N

SC

NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

s

NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 14: INCF 2013 - Uniform Resource Layer

Uniform search

httpneuinfoorg

Data about the subthalamus

httpneuinfoorg

The Brain and itsrsquo data

Ontologies provide a semantic framework for understanding dataresource landscape

Data sources included in NIF-Complete list httpdisconeuinfoorg-Services httpneuinfoorgdevelopersStriatum

HypothalamusOlfactory bulb

Cerebral cortex

Brain

Bra

in r

egio

n

Data source

VadimAstakhov Kepler Workflow Engine

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

GR

ID

Bio

Nu

mb

ers

Bra

inIn

fo

Bra

inSp

an1

Bra

inSp

an3

BR

EDE

Cel

lImag

eLib

rary

Cer

ebel

lar

Pla

tfo

rm

Ch

emo

rece

pto

rs

Co

riel

lTis

sue

CTD

Dru

g R

elat

ed G

ene

Dat

abas

e

EAM

Ense

mb

lHu

man

Epig

eno

mic

s P

roje

ct

Gem

ma

GEN

SAT

Gra

nts

go

v

Hea

lth

Dat

a

HP

O A

nn

ota

tio

ns

IBV

D

Lab

fo

r V

isu

al N

euro

scie

nce

MG

ITra

nsg

enes

Mo

nar

ch

Nat

ion

al M

ou

se M

etab

olic

Ph

eno

typ

ing hellip

Neu

rod

atab

ase

Neu

rofe

d

Neu

ron

DB

NIF

Inte

grat

ed A

nim

als

NIF

Inte

grat

ed C

ell L

ines

NIF

Inte

grat

ed D

isea

se

NIF

Inte

grat

ed N

SC

NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

s

NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 15: INCF 2013 - Uniform Resource Layer

Data about the subthalamus

httpneuinfoorg

The Brain and itsrsquo data

Ontologies provide a semantic framework for understanding dataresource landscape

Data sources included in NIF-Complete list httpdisconeuinfoorg-Services httpneuinfoorgdevelopersStriatum

HypothalamusOlfactory bulb

Cerebral cortex

Brain

Bra

in r

egio

n

Data source

VadimAstakhov Kepler Workflow Engine

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

GR

ID

Bio

Nu

mb

ers

Bra

inIn

fo

Bra

inSp

an1

Bra

inSp

an3

BR

EDE

Cel

lImag

eLib

rary

Cer

ebel

lar

Pla

tfo

rm

Ch

emo

rece

pto

rs

Co

riel

lTis

sue

CTD

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Mo

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Nat

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Ph

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Neu

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DB

NIF

Inte

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NIF

Inte

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Inte

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Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 16: INCF 2013 - Uniform Resource Layer

The Brain and itsrsquo data

Ontologies provide a semantic framework for understanding dataresource landscape

Data sources included in NIF-Complete list httpdisconeuinfoorg-Services httpneuinfoorgdevelopersStriatum

HypothalamusOlfactory bulb

Cerebral cortex

Brain

Bra

in r

egio

n

Data source

VadimAstakhov Kepler Workflow Engine

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

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DB

Alle

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Ph

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Neu

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NIF

Inte

grat

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Inte

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Inte

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Inte

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Inte

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NIF

Mo

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Res

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ross

road

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YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 17: INCF 2013 - Uniform Resource Layer

LETrsquoS PLAY A GAME

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

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y

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NIF

Inte

grat

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Inte

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NIF

Inte

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se

NIF

Inte

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NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

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NIF

Blo

gs

NIF

New

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On

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Pu

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edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 18: INCF 2013 - Uniform Resource Layer

What is this

httpneuinfoorg

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

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od

yReg

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y

BA

MS

Bio

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ID

Bio

Nu

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Bra

inIn

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Bra

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Bra

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rary

Cer

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Co

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Lab

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ITra

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Mo

nar

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Nat

ion

al M

ou

se M

etab

olic

Ph

eno

typ

ing hellip

Neu

rod

atab

ase

Neu

rofe

d

Neu

ron

DB

NIF

Inte

grat

ed A

nim

als

NIF

Inte

grat

ed C

ell L

ines

NIF

Inte

grat

ed D

isea

se

NIF

Inte

grat

ed N

SC

NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

s

NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 19: INCF 2013 - Uniform Resource Layer

Homunculus

httpneuinfoorg

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

GR

ID

Bio

Nu

mb

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Bra

inIn

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Bra

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Bra

inSp

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BR

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rary

Cer

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Mo

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Nat

ion

al M

ou

se M

etab

olic

Ph

eno

typ

ing hellip

Neu

rod

atab

ase

Neu

rofe

d

Neu

ron

DB

NIF

Inte

grat

ed A

nim

als

NIF

Inte

grat

ed C

ell L

ines

NIF

Inte

grat

ed D

isea

se

NIF

Inte

grat

ed N

SC

NIF

Inte

grat

ed S

oft

war

e

NIF

Mo

del

s

NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 20: INCF 2013 - Uniform Resource Layer

HomunculusCareful mapping of the entire somatosensory cortex yields a representation of the amount of area devoted to sensing each body region

From the homunculus we learn that humans pay attention to the lips hands and genitals

httpneuinfoorg

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

enes

DB

Alle

nIn

stit

ute

An

tib

od

yReg

istr

y

BA

MS

Bio

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Bio

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Bra

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Mo

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Ph

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Neu

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NIF

Inte

grat

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Inte

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NIF

Inte

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se

NIF

Inte

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NIF

Inte

grat

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NIF

Mo

del

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NIF

Blo

gs

NIF

New

s

OD

E

On

eMin

d

OSB

Pu

bM

edH

ealt

h

Res

earc

hC

ross

road

s

T3D

B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 21: INCF 2013 - Uniform Resource Layer

Each animal has a set of body regions that it is particularly concerned with

httpneuinfoorg

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

AB

CD

Agi

ngG

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DB

Alle

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Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 22: INCF 2013 - Uniform Resource Layer

Is there a data homunculus

If so how can we know it

httpneuinfoorg

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

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30

40

50

60

70

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100

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Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 23: INCF 2013 - Uniform Resource Layer

Medial lemniscus of midbrain

Habenulo-interpeduncular tract of midbrain

Commissural nucleus of vagus nerve

Medullary raphe nuclear complex

Dorsal longitudinal fasciculus of medulla

Trochlear nerve root

Spinothalamic tract of midbrain

Superior cerebellar peduncle of midbrain

Medial longitudinal fasciculus of midbrain

Central tegmental tract of midbrain

Dorsal longitudinal fasciculus of midbrain

Vagus nerve root

Accessory nerve root

White matter of the cerebellar cortex

Oculomotor nerve root

Brain

Striatum

Amygdala

Thalamus

Cerebellar cortex

Cerebellum

Hypothalamus

Forebrain

Midbrain

Substantia nigra

Third ventricle

Ventral tegmental area

Pons

Medulla oblongata

Cochlear nuclear complex

Most popular Least popular

Brain region popularity

httpneuinfoorg

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

10

20

30

40

50

60

70

80

90

100

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Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 24: INCF 2013 - Uniform Resource Layer

Which brain regions have most annotations

0

10

20

30

40

50

60

70

80

90

0

10

20

30

40

50

60

70

80

90

Level 0 Brain

Level 1 Hindbrain

Level 2 Medulla

Level 3 Amygdalaeg

Sum per LevelSum for Major Brain Region

httpneuinfoorg

0

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50

60

70

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100

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road

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e

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Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 25: INCF 2013 - Uniform Resource Layer

0

10

20

30

40

50

60

70

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100

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Inte

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Res

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ross

road

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B

Vis

iom

e

YPED

Which data source has any data for brain regions

BAMS BioNot BrainInf

oBrainMaps Funded

Grants

Connectivity

OMIMMGI

httpneuinfoorg

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 26: INCF 2013 - Uniform Resource Layer

Why donrsquot you have my database of Commissural nucleus of vagusnerve images

bull Please register them with NIF

ndash httpneuinfoorgcindyhtm

bull E-mail abandrowskiucsdedu or infoneuinfoorg

bull Poster OP05 or

bull Demo session D19

httpneuinfoorg

Maryann Martone PI

Page 27: INCF 2013 - Uniform Resource Layer

Maryann Martone PI