INBRE Steering Committee Informational Meeting

INBRE Competitive Renewal

Submitted: July 29, 2014Funding Period: May 1, 2015 – April 30, 2020Study Section Review: November 2014Council Meeting: January/February 2015

Organizational Structure of the Arkansas INBRE

Administrative CoreBioinformatics CoreResearch Technology CoreDevelopmental Research Project Program

INBRE Competitive Renewal

Admin Core

Specific Aim 1. Provide overall operational support to the network (i.e., provide budgetary and fiscal services, organize and conduct Steering Committee and External Advisory Committee meetings).

Specific Aim 2. Provide scientific leadership to coordinate research activities within the Arkansas INBRE’s thematic scientific focus (i.e., training, mentoring, career development).

Specific Aim 3. Broaden opportunities for undergraduate participation in research in Arkansas, regardless of the location of the student’s home or educational institution.

Director: Larry Cornett, UAMS

Specific Aim 4. Foster statewide networking and communication among INBRE programs and participants.

Specific Aim 5. Support programs to expand participation by members of underrepresented minority groups in the Arkansas INBRE.

Specific Aim 6. Represent the Arkansas INBRE in the national and regional networks of IDeA programs.

Admin Core Contd.

Administrative Core

Bioinformatics CoreResearch Technology CoreDevelopmental Research Project Program

INBRE Competitive Renewal

Bioinformatics Core

Specific Aim 1. Provide training in bioinformatics to support biomedical research across Arkansas.

Specific Aim 2. Provide bioinformatics research support and consulting services to investigators in the Arkansas INBRE network.

Co-DirectorsGalina Glazko, UAMS

Elizabeth Pierce, UALR

Bioinformatics Core Contd.· This fall 2014, we are welcoming 2 new MS students

and 2 new PhD students · So far this year we have graduated 2 PhD Students· Our current student head count stands at 22 students · With the new MS curriculum finalized, we can focus this

year on recruiting students interested in pursuing research in the following 4 areas:

Drug Design Integrated Bioinformatics & Genomics Computational Biology Biomedical Informatics

Workshops in the Fall/Spring Semesters

• Building and Using a Rocks Cluster for Bioinformatics

• Survey of Bioinformatics Tools on a Linux System

• Machine Learning for Bioinformatics

• Bash Scripting for Bioinformatics

• Processing Next-gen Sequence Data on a Linux System

The Arkansas INBRE webpage and a Bioinformatics Core Support Request Form are available on the Division of Biomedical Informatics website (http://dbmi.uams.edu/)

The listserv INBRE Research Support with the email address of inbre_research_support@uams.edu has been created and Support Requests are automatically sent to gvglazko@uams.edu; YRahmatallah@uams.edu; phwilliams@ualr.edu. These changes will be announced on the Arkansas INBRE Bioinformatics Core and Arkansas Bioinformatics Network webpagesGSAR (“Gene Set Analysis in R”) is freely available on the Bioconductor website www.bioconductor.org and will have a link on the DBMI website and the Arkansas INBRE page

New Ways to Support Research

Plans to Facilitate Collaboration and Training

• MCBIOS 2015 will be held at the Statehouse Convention Center , Little Rock, March 12 - 14, 2015

• UALR/UAMS Graduate Program in Bioinformatics will have a recruiting booth

• A One-Day Omics Workshop will be organized with 3 options in conjunction with the MCBIOS Conference:  – Transcriptomics Data Analysis Workshop presented by Dr.

Frank Emmert-Streib, Center for Cancer Research and Cell Biology , Queen's University Belfast , UK

– Genomics Data Analysis Workshop, TBN– Proteomics (Metabolomics?) Data Analysis Workshop, TBN

• We will hold an Omics Poster Session as part of the UAMS Research Day (also coordinated with the UALR Research Day) in April 2015

Administrative CoreBioinformatics Core

Research Technology CoreDevelopmental Research Project Program

INBRE Competitive Renewal

Research Technology Core

Diagram of the Arkansas INBRE Research Technology Core. The three branches of this core will facilitate cutting-edge research and provide education on state-of-the-art technologies at Arkansas INBRE partner and affiliated institutions.

Director: Alan Tackett, UAMS

Specific Aim 1. Support undergraduate research by providing Core Facility Vouchers to undergraduate faculty and students.

Specific Aim 2. Invest in cutting-edge core facility technology development by providing Core Facility Development Awards to core facilities at UAMS and UAF.

• Core facilities will apply for funds to implement some new approach/service into their facility

• Awards will be up to $3,500, and we anticipate awarding 4–6 yearly• Priority will be given to core facilities that have large numbers of

INBRE-supported PUI users• These awards will provide a mechanism by which the Arkansas

INBRE can support Core Facility development, while still providing general access to all Core Facilities for PUI users

• Faculty Research Core Facility Vouchers • Student Research Core Facility Vouchers• Faculty Curriculum Core Facility Vouchers

Specific Aim 3. Promote the Arkansas INBRE Research Technology Core and provide on-site educational seminars at Arkansas undergraduate institutions.• On-site promotional activities and educational seminars

(1) a one-hour seminar (30 minutes for Dr. Tackett to describe opportunities through the Research Technology Core and 30 minutes of training given by a core facility director)

(2) display of a Research Technology Core poster detailing the Core Facility Voucher Program and available core facilities

(3) one-on-one meetings with INBRE-funded faculty and students(4) meetings with non-INBRE-funded faculty and students.

• Social Media Hub

Diagram of the Arkansas INBRE Research Technology Core personnel and roles.

Administrative CoreBioinformatics CoreResearch Technology Core

Developmental Research Project Program

INBRE Competitive Renewal

Developmental Research Project Program (DRPP)

Specific Aim 1. Recruit new faculty to select partner institutions.

Specific Aim 2. Support biomedical research by funding research grants for mentored faculty at partner and affiliate institutions.

Specific Aim 3. Sustain the research career development of faculty at partner and affiliate institutions by mentoring and other activities.

Director: Helen Beneš, UAMS

DRPP Contd. Average

Award AmtYR 1 YR 2 YR 3 YR 4 YR 5

Summer Research Grants 25,500 153,000 153,000 153,000 153,000 153,000

Pilot Study Grants 40,000 80,000 120,000 120,000 172,000 274,000

Research Development Grants 100,000

1,000,000

1,000,000

1,000,000

1,000,000

1,000,000

Shared Instrumentation Grants >5,000 197,000 52,000 42,000    

Faculty Recruitment Packages

100,000 over 3 years

35,000 140,000 150,000 140,000 35,000

Mini Sabbaticals/Training 7,000 28,000 28,000 28,000 28,000 28,000

Seminar Series/Workshops 7,000 7,000 7,000 7,000 10,000

Total DRPP 1,500,000

1,500,000

1,500,000

1,500,000

1,500,000

Funding Mechanisms — Types of Grants

Type of Grant Duration Average Award

Amount

Allowable Expenses

Summer Research Grants

Summer(10 weeks)

Up to $25,500

Personnel (PL and student), supplies, travel and other costs as justified

Pilot Study GrantsVariable(4–12 months)

Up to $40,000

Personnel (PL, student, and technician), small equipment, supplies, travel and others costs as justified

Research Development Grants

2.5 years $250,000

Personnel (PL, student, and technician), equipment, supplies, travel, and other costs as justified

Shared Instrumentation Grants

1 year(12 months)

$5,000 - $50,000

Purchase cost of instrument only

Career Development

Research Career Development Groups – “Chalk talks” to help Project Leaders with research development

Seminar Series – up to $1,200 for Project Leaders to invite speakers to their home institution

Mini-Sabbaticals for Technical Training – up to $7,000 for Project Leaders to learn special techniques at core facilities

Proposal-Writing Workshops – Arkansas INBRE Project Leaders will be able to take advantage of the annual AREA grant writing workshops offered by Kentucky INBRE

Proposed Timeline

Proposal Review CommitteeGwen V. Childs, PhD, Professor & Chair, Neurobiology &

Developmental Science, UAMS

Andrea Duina, PhD, Assoc. Professor, Biology, Hendrix College

Howard Hendrickson, PhD, Assoc. Professor, Pharmaceutical Sciences, UAMS

Argelia Lorence, PhD, Professor, Chemistry and Physics, ASU

David Paul, PhD, Assoc. Professor, Chemistry and Biochemistry, UAF

Marty Perry, PhD, Assoc. Professor, Chemistry, OBU

Antonie Rice, PhD, Professor & Chair, Dept. of Chemistry and Physics

Jerry Ware, PhD, Professor, Physiology and Biophysics, UAMS

Research Development Committee

Jerry Darsey, PhD, Assoc. Professor, Chemistry, UALR INBRE mentor; previous INBRE proposal reviewer; chemistry/biochemistry

Robert J. Griffin, PhD, Assoc. Professor, Radiation Oncology, UAMS

INBRE mentor for current Project Leader; molecular biology/cell and cancer biology

Lori Hensley, PhD, Assoc. Professor, Biological Sciences, OBU INBRE Project Leader (current), cell and cancer biology

Brent Hill, PhD, Assoc. Professor, Biology, UCA INBRE Project Leader (current), physiology/cell biology

Malathi Srivatsan, PhD, Assoc. Professor, Biological Sciences, ASUINBRE Project Leader (former), neuroscience/cell biology/molecular biology

Daniel Voth, PhD, Assist. Professor, Microbiology and Immunology, UAMS

INBRE mentor for current Project Leader; infectious disease/molecular biology/cell

biology