in fdg pet ct imaging of the chest · 72-year-old man, 23 mm spn in lul lepidic pattern...

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04/10/2014 1 María José García Velloso Servicio de Medicina Nuclear Clínica Universidad de Navarra mjgarciave@unav.es Pitfalls in FDG PETCT Imaging of the Chest Pärnu (Estonia) Wednesday, October 8, 2014 10:40-11:20 False negative – Tumors with low FDG metabolism: • Mucinous lung adenocarcinoma • Lepidic pattern adenocarcinoma • Carcinoid Tumor – Microscopic Disease False positive: inflammation/ infection – Tuberculsis, Granulomatosis, Sarcoidosis, Aspergilosis, Histoplasmosis. Pneumonía, Abscess – Pleurodesis – Reactive lymphadenopathy FDG cellular metabolism

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Page 1: in FDG PET CT Imaging of the Chest · 72-year-old man, 23 mm SPN in LUL Lepidic pattern adenocarcinoma SUV=0,78 SUV=0,95 08/2013 SUV=0,98 03/2014 3 h. Dual-Time ΔSUV= 22% 1. Lung

04/10/2014

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María José García VellosoServicio de Medicina NuclearClínica Universidad de Navarra

[email protected]

Pitfalls in FDG PET‐CT Imagingof the Chest

Pärnu (Estonia)

Wednesday, October 8, 201410:40-11:20

• False negative– Tumors with low FDG metabolism:

• Mucinous lung adenocarcinoma• Lepidic pattern adenocarcinoma• Carcinoid Tumor

– Microscopic Disease

• False positive: inflammation/ infection– Tuberculsis, Granulomatosis, Sarcoidosis,

Aspergilosis, Histoplasmosis.– Pneumonía, Abscess– Pleurodesis– Reactive lymphadenopathy

FDG cellular metabolism

Page 2: in FDG PET CT Imaging of the Chest · 72-year-old man, 23 mm SPN in LUL Lepidic pattern adenocarcinoma SUV=0,78 SUV=0,95 08/2013 SUV=0,98 03/2014 3 h. Dual-Time ΔSUV= 22% 1. Lung

04/10/2014

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Paravertebral Abscess and spondylodiscitis(Staphilococcus Aureus)

SUVmax=8,4

58 year-old man with mass in upper right lobe, destruction of T3-T4

Hamartoma73-year-old man, Colorectal Cancer. SPN LUL

Page 3: in FDG PET CT Imaging of the Chest · 72-year-old man, 23 mm SPN in LUL Lepidic pattern adenocarcinoma SUV=0,78 SUV=0,95 08/2013 SUV=0,98 03/2014 3 h. Dual-Time ΔSUV= 22% 1. Lung

04/10/2014

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Pneumonia (Pneumocystis carinii and Staphilococcus aureus)

47-year-old woman, Breast Cancer. Neoadjuvant Therapy

Sarcoidosis

SUVmax=5

51-year-old woman with breast cancer. Neoadjuvant Therapy

Page 4: in FDG PET CT Imaging of the Chest · 72-year-old man, 23 mm SPN in LUL Lepidic pattern adenocarcinoma SUV=0,78 SUV=0,95 08/2013 SUV=0,98 03/2014 3 h. Dual-Time ΔSUV= 22% 1. Lung

04/10/2014

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SUVmax=5

Tuberculosis

SUVmax=9SUVmax=12

40-year-old man with pulmonary mass and subcarinal lymphadenopathy

Pneumoconiosis62-year-old man, ex-smoker. Asbestos exposure. Respiratory Infection, Lymphadenopaty in thorax.

Page 5: in FDG PET CT Imaging of the Chest · 72-year-old man, 23 mm SPN in LUL Lepidic pattern adenocarcinoma SUV=0,78 SUV=0,95 08/2013 SUV=0,98 03/2014 3 h. Dual-Time ΔSUV= 22% 1. Lung

04/10/2014

5

Radiation-induced Pneumonitis39-year-old woman, Ovarian cancer recurrence.

Thoracothomy

Rib fracture

71-year-old man. Lung Adenocarcinoma, surgery (1 month)

Page 6: in FDG PET CT Imaging of the Chest · 72-year-old man, 23 mm SPN in LUL Lepidic pattern adenocarcinoma SUV=0,78 SUV=0,95 08/2013 SUV=0,98 03/2014 3 h. Dual-Time ΔSUV= 22% 1. Lung

04/10/2014

6

72-year-old man, 23 mm SPN in LUL

Lepidic pattern adenocarcinoma

SUV=0,95SUV=0,78

08/2013

SUV=0,98

03/2014

3 h. Dual-TimeΔSUV= 22%

1. Lung

2. Pleura

3. Lymph nodes

4. Thymic gland

5. Heart and vessels

6. Esophagus

7. Muscles

8. Bones and joints

9. Bone marrow

FDG PET-CT. Pitfalls

Page 7: in FDG PET CT Imaging of the Chest · 72-year-old man, 23 mm SPN in LUL Lepidic pattern adenocarcinoma SUV=0,78 SUV=0,95 08/2013 SUV=0,98 03/2014 3 h. Dual-Time ΔSUV= 22% 1. Lung

04/10/2014

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Pleural Metastasis70-year-old man, Lung adenocarcinoma treated

Talc Pleurodesis66-year-old woman Lung Adenocarcinoma stage IV treated

Page 8: in FDG PET CT Imaging of the Chest · 72-year-old man, 23 mm SPN in LUL Lepidic pattern adenocarcinoma SUV=0,78 SUV=0,95 08/2013 SUV=0,98 03/2014 3 h. Dual-Time ΔSUV= 22% 1. Lung

04/10/2014

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EmpyemaSUVmax=7,6 SUVmax=3,1SUVmax=11,8

68-year-old man, NSCLC LUL (14 cm) and lymphadenopathy

66-year-old man. CT: 2 cm SPN in RUL AdenocarcinomapT1 pN2 (4R)

SUVmax=3,3

cT1 N0

Page 9: in FDG PET CT Imaging of the Chest · 72-year-old man, 23 mm SPN in LUL Lepidic pattern adenocarcinoma SUV=0,78 SUV=0,95 08/2013 SUV=0,98 03/2014 3 h. Dual-Time ΔSUV= 22% 1. Lung

04/10/2014

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Mononucleosis35-year-old woman, suspected lymphoma

SUVmax N1=3,4

SUVmax=6,4

SUVmax N2=3,6 EBUS FP

Squamous cell Ca.pT1a N0

71-year-old man.CT: 17 mm SPN in RUL

Page 10: in FDG PET CT Imaging of the Chest · 72-year-old man, 23 mm SPN in LUL Lepidic pattern adenocarcinoma SUV=0,78 SUV=0,95 08/2013 SUV=0,98 03/2014 3 h. Dual-Time ΔSUV= 22% 1. Lung

04/10/2014

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Page 11: in FDG PET CT Imaging of the Chest · 72-year-old man, 23 mm SPN in LUL Lepidic pattern adenocarcinoma SUV=0,78 SUV=0,95 08/2013 SUV=0,98 03/2014 3 h. Dual-Time ΔSUV= 22% 1. Lung

04/10/2014

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Hyperplasia Thymus

Thymus NHL

Page 12: in FDG PET CT Imaging of the Chest · 72-year-old man, 23 mm SPN in LUL Lepidic pattern adenocarcinoma SUV=0,78 SUV=0,95 08/2013 SUV=0,98 03/2014 3 h. Dual-Time ΔSUV= 22% 1. Lung

04/10/2014

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Atrial Fibrillation69-year-old-man, NSCLC, Chemo-Radiotherapy

64-year-old man, Bladder Ca. SPN in RUL

Esophagus

Esophagitis

Page 13: in FDG PET CT Imaging of the Chest · 72-year-old man, 23 mm SPN in LUL Lepidic pattern adenocarcinoma SUV=0,78 SUV=0,95 08/2013 SUV=0,98 03/2014 3 h. Dual-Time ΔSUV= 22% 1. Lung

04/10/2014

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Esophagus

Gastroesophageal RefluxNeoplasia Esophagitis

Brown FatUSA Fat

Page 14: in FDG PET CT Imaging of the Chest · 72-year-old man, 23 mm SPN in LUL Lepidic pattern adenocarcinoma SUV=0,78 SUV=0,95 08/2013 SUV=0,98 03/2014 3 h. Dual-Time ΔSUV= 22% 1. Lung

04/10/2014

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NHL refractary to Chemotherapy

Acute Fracture

51-year-old man, SPN in LLL.

Page 15: in FDG PET CT Imaging of the Chest · 72-year-old man, 23 mm SPN in LUL Lepidic pattern adenocarcinoma SUV=0,78 SUV=0,95 08/2013 SUV=0,98 03/2014 3 h. Dual-Time ΔSUV= 22% 1. Lung

04/10/2014

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Paget Disease

Acute Fracture