imunologi_dasar.ppt;filename_= utf-8''imunologi dasar.ppt

8/18/2019 IMUNOLOGI_DASAR.ppt;filename_= UTF-8''IMUNOLOGI DASAR.ppt

1/15

IMUNOLOGI DASARIMUNOLOGI DASAR


2/15

SISTIM IMUN

NONSPESIFIK

SPESIFIK


3/15

NON SPESIFIK

FISIK CAIRAN SELULER

•KULIT•SELAPUT LENDIR•SILIA•BATUK•BERSIN•DIARE

•LISOZIM•SEKRESI SEBASEUS•ASAM LAMBUNG•LAKTOFERIN•ASAM NEURAMINIK •KOMPLEMEN•INTERFERON•SITOKIN•CRP

•FAGOSIT - MONONUKLEAR - POLIMORFONUKLEAR•SEL NK •SEL MAST•BASOFIL


4/15

SELULERHUMORAL

IMUN SPESIFIK

Sel B

-IgD

-IgM

-IgG

-IgE

-IgA

Sel T

- Th1

- Th2

- Ts/T

- T!"h

-CTL


5/15

ANTIBODI ANTIBODI

PROTEIN #ANG DIBENTUK SELPROTEIN #ANG DIBENTUK SELPLASMA SETELAH BERTEMU ANTIGENPLASMA SETELAH BERTEMU ANTIGEN

BERFUNGSI $BERFUNGSI $

- Pe%gh&'&%g (%")ge% !e%g(% e*e+",- Pe%gh&'&%g (%")ge% !e%g(% e*e+", - e%g(+")*+(% +,.lee%- e%g(+")*+(% +,.lee%

- ,.s,%)s(s)- ,.s,%)s(s)

- e%)%g+("+(% e(+s) )%((s)- e%)%g+("+(% e(+s) )%((s) - e%e"(l)s) ",+s)%- e%e"(l)s) ",+s)%

- e%0eg(h )+("(% +&(% .(",ge% !e%g(% sel- e%0eg(h )+("(% +&(% .(",ge% !e%g(% sel.e%(&.e%(&

- Agl&")%(", +&(" '(g) (%")ge%- Agl&")%(", +&(" '(g) (%")ge%

- e%0eg(h ge(+(% )+,,g(%)se- e%0eg(h ge(+(% )+,,g(%)se


6/15

INTERFERONINTERFERON

PROTEIN #ANG DIHASILKAN SELPROTEIN #ANG DIHASILKAN SEL

TUBUH SEBAGAI RESPON TERHADAP TUBUH SEBAGAI RESPON TERHADAP

IRUSIRUS

FUNGSIFUNGSI

- A+")*(s) NK sel- A+")*(s) NK sel - Me%g)%!&+s) sel se+)"( e%(!) es)s"e%- Me%g)%!&+s) sel se+)"( e%(!) es)s"e%

"eh(!(."eh(!(.

3)&s3)&s


7/15

KOMPLEMENKOMPLEMEN

MELISISKAN BAKTERI DGN MERUSAKMELISISKAN BAKTERI DGN MERUSAK

DINDINGN#ADINDINGN#A

MENGERAHKAN MAKROFAG KEMENGERAHKAN MAKROFAG KE

TEMPAT BAKTERI DAN TEMPAT BAKTERI DAN

MENGAKTIFKANN#AMENGAKTIFKANN#A

OPSONISASI BAKTERIOPSONISASI BAKTERI


8/15


9/15

REAKSI HIPERSENSITIFITASREAKSI HIPERSENSITIFITAS


10/15

RESPON IMUN #ANG BERLEBIHANRESPON IMUN #ANG BERLEBIHAN

MENIMBULKAN KERUSAKANMENIMBULKAN KERUSAKAN

4ERINGAN TUBUH 4ERINGAN TUBUH


11/15

REAKSI HIPERSENSITIFITASREAKSI HIPERSENSITIFITAS

REAKSI TIPE IREAKSI TIPE I

5e(+s) 0e.("65e(+s) 0e.("6

REAKSI TIPE IIREAKSI TIPE II

5e(+s) s)",",+s)+65e(+s) s)",",+s)+6 REAKSI TIPE IIIREAKSI TIPE III

5e(+s) +,.le+ )&%65e(+s) +,.le+ )&%6 REAKSI TIPE IREAKSI TIPE I

5e(+s) h).ese%s)")7"(s l('("65e(+s) h).ese%s)")7"(s l('("6


12/15

REKASI TIPE IREKASI TIPE I

D)+e%(l se'(g() e(+s) (leg)D)+e%(l se'(g() e(+s) (leg)

T)'&l sege( ses&!(h (lege% (s&+ T)'&l sege( ses&!(h (lege% (s&+

P(",ge%es)sP(",ge%es)s (%")ge% !)"(%g+(. *(g,s)" -8 !).ese%"(s)+(% +e sel Th2 -8(%")ge% !)"(%g+(. *(g,s)" -8 !).ese%"(s)+(% +e sel Th2 -8

Th2 ele.(s s)",+)% 9(%g e(%gs(%g sel B e%gh(s)l+(% Th2 ele.(s s)",+)% 9(%g e(%gs(%g sel B e%gh(s)l+(%

IgE -8 IgE !))+(" sel M(s":IgE -8 IgE !))+(" sel M(s":

B)l( (lege% 9(%g s(( (s&+ "&'&h -8 (lege% !) )+(" IgEB)l( (lege% 9(%g s(( (s&+ "&'&h -8 (lege% !) )+(" IgE

9(%g "e)+(" sel M(s" -8 sel M(s" e%g(l() !eg(%&l(s) -89(%g "e)+(" sel M(s" -8 sel M(s" e%g(l() !eg(%&l(s) -8!)+el&(+(% e!)(", )%((s) -8 e(+s) ").e I!)+el&(+(% e!)(", )%((s) -8 e(+s) ").e I

Pe%9(+)" $ (s( ',%+h)(le; h)%)")s;Pe%9(+)" $ (s( ',%+h)(le; h)%)")s;

&")+()(; !e(")")s (",.)+&")+()(; !e(")")s (",.)+


13/15

REAKSI TIPE IIREAKSI TIPE II

REAKSI SITOTOKSIK REAKSI SITOTOKSIK

ANTIBODI IgG DAN IgM MENGIKAT ANTIGENANTIBODI IgG DAN IgM MENGIKAT ANTIGEN

#G MERUPAKAN BAGIAN TUBUH #G MERUPAKAN BAGIAN TUBUH

PATOGENESISPATOGENESIS (%")',!) e%g)+(" (%")ge% )l)+ "&'&h .e%(& -8(%")',!) e%g)+(" (%")ge% )l)+ "&'&h .e%(& -8

e%g(+")*+(% s)s") +,.lee% -8 l)s)s%9( sel ("(& ()%g(%e%g(+")*+(% s)s") +,.lee% -8 l)s)s%9( sel ("(& ()%g(%

"&'&h:"&'&h:

CONTOH $CONTOH $ DESTRUKSI ERITROSIT PADA REAKSIDESTRUKSI ERITROSIT PADA REAKSI TRANFUSI; MIASTENIA GRAIS; TIROTOKSIKOSIS TRANFUSI; MIASTENIA GRAIS; TIROTOKSIKOSIS


14/15

REAKSI TIPE IIIREAKSI TIPE III

REAKSI KOMPLEK IMUNREAKSI KOMPLEK IMUN ANTIBODI $ANTIBODI $ IgG !(%IgG !(% IgMIgM ANTIGEN $ANTIGEN $ KUMAN PATOGEN; 4ARINGAN TUBUH SENDIRI;KUMAN PATOGEN; 4ARINGAN TUBUH SENDIRI;

BAHAN TERGHIRUPBAHAN TERGHIRUP

KOMPLEK Ag-A' TIDAK BISA DIHILANGKANKOMPLEK Ag-A' TIDAK BISA DIHILANGKANSEPENUHN#A AKIBAT GANGGUAN FUNGSISEPENUHN#A AKIBAT GANGGUAN FUNGSIFAGOSITFAGOSIT

PATOGENESISPATOGENESIS (%")ge% e'e%"&+ +,.le+ Ag-A' -8 e%e.el .(!( ()%g(%(%")ge% e'e%"&+ +,.le+ Ag-A' -8 e%e.el .(!( ()%g(%

("(& .e'&l&h !((h -8 e%g(+")*+(% +,.lee% -8("(& .e'&l&h !((h -8 e%g(+")*+(% +,.lee% -8ele.(s+(% (0,.h(ge 0he,"(0")0 *(0", -8 (+,*(gele.(s+(% (0,.h(ge 0he,"(0")0 *(0", -8 (+,*(g!("(%g +e +,.le+ Ag-A' -8 (+,*(g e&s(+ ()%g(%!("(%g +e +,.le+ Ag-A' -8 (+,*(g e&s(+ ()%g(%

CONT


15/15

REAKSI TIPE IVREAKSI TIPE IV

HIPERSENSITIFITAS LAMBAT 582= (6HIPERSENSITIFITAS LAMBAT 582= (6 DIBAGI MEN4ADI $DIBAGI MEN4ADI $ - Del(9e! T9.e H9.ese%s)")3)"9 5el(l&) CD =>6- Del(9e! T9.e H9.ese%s)")3)"9 5el(l&) CD =>6

- T sel Me!)("e! C9",l9s)s 5el(l&) CD ?>6- T sel Me!)("e! C9",l9s)s 5el(l&) CD ?>6 PATOGENESIS DTHPATOGENESIS DTH (%")ge% e(%gs(%g T CD=> e%(!) Th1 -8 Th1(%")ge% e(%gs(%g T CD=> e%(!) Th1 -8 Th1

ele.(s+(% INF(l*( -8 e%g(+")*+(% (+,*(g -8 (+,*(gele.(s+(% INF(l*( -8 e%g(+")*+(% (+,*(g -8 (+,*(gele.(s+(% e%@)h)!,l)")+; ,+s)ge% e(+")*; ,+s)!( %)"("ele.(s+(% e%@)h)!,l)")+; ,+s)ge% e(+")*; ,+s)!( %)"("

!(% s)",+)% .,)%((s) -8 +e&s(+(% ()%g(%!(% s)",+)% .,)%((s) -8 +e&s(+(% ()%g(% C,%",h $ e+(s) g(%&l,(; !e(")")s +,%"(+C,%",h $ e+(s) g(%&l,(; !e(")")s +,%"(+

PATOGENESIS T Cell Me!)("e! C9",l9s)sPATOGENESIS T Cell Me!)("e! C9",l9s)s SEL CD?> 'e&'(h CTL -8 'e"e& !e%g(% ()%g(% "&'&hSEL CD?> 'e&'(h CTL -8 'e"e& !e%g(% ()%g(% "&'&h

9(%g !)+e%(l se'(g() &s&h -8 +e&s(+(% ()%g(%9(%g !)+e%(l se'(g() &s&h -8 +e&s(+(% ()%g(%

C,%",h $ .e%9(+)" (&",)&%C,%",h $ .e%9(+)" (&",)&%

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