impact of prevagen on sleep quality - truth in advertising€¦ · 27 participants reported getting...

Impact of Prevagen on Sleep QualityPrevagen Increases Amount of Sleep

Prevagen Decreases Nightly Wake-upsPrevagen Helps People Get to Sleep

Prevagen Improves Overall Sleep

2009 © CopyrightAll Rights Reserved

Prevagen Quality of Life Study

7.20

7.00

6.80

6.60

6.40

6.20

6.00

5.80

5.60

5.40

5.20

All subjectsn = 27

Subjects reporting an increasen = 18

6.18hours

6.33hours

6.77hours

5.93hours

6.58hours

7.05hours

Amou

nt o

f Sl

eep

(hou

rs)

Day 0

Day 90

Day 8

The Prevagen Quality of Life Study was an open-label study of 55 generally healthy participants over a 90 day period measuring changes in overall cognition, quality of sleep, energy, mood, pain, and general health. Changes in performance were measured via a standardized battery of questions.

The results of the study show improved performance across these parameters with particularly striking results on sleep especially for those who reported having poor sleep at Day 0. In general, participants who rated their sleep as satisfactory or better at Day 0 saw modest improvements in sleep quality during the 90 day study. However, those with poor quality sleep at Day 0 experienced significant improvement.

The following results show sleep improvements for participants who self-reported having poor quality of sleep at Day 0. No participants discontinued the study due to an adverse event.

Impact of Prevagen on Sleep Quality

Amount of Sleep (Subjects Reporting 7 hours or less at Day 0)

Question 1 Discussion:27 participants reported getting 7 hours of sleep or less per night. The mean amount of sleep for this group at Day 0 was 6.2 hours. The average amount of sleep at the conclusion of the study was 6.8 hours per night, or nearly 40 minutes of sleep or more per night. 18 out of 27 (67%) increased their sleep while in the study and evaluating their sleep improvement shows they gained an average of 67 minutes per night over the 90 day period, a significant improvement.

2009 © Copyright. All Rights Reserved. Prevagen Quality of Life Study

Prevagen Increases Amount of Sleep

Question 1:“How much sleep do you usually get at night?”Answer choices: Indication of time in hours and minutes (rounded to the closest ¼ hour).

5.0

4.5

4.0

3.5

3.0

2.5

2.0

1.5

1.0

0.5

0

Day 0 Day 8 Day 90

3.56times

1.91times 1.81

times

Num

ber

of W

akin

g Ev

ents

/Nig

ht


Number of Waking Events Per Night(Subjects Reporting at Least Two (2) Waking Events at Day 0)

Question 2 Discussion:Sleep disturbances are a major impediment to quality of sleep. 48 participants out of a total of 55 reported waking up two or more times nightly, representing 87% of the study population. In this group the average number of times awakened was 3.6 times per night at Day 0. There was an immediate and significant decline at Day 8 to an average 1.9 waking events. This benefit was maintained to Day 90 with a further decline in wake-ups to an average of 1.8.


Prevagen Decreases Nightly Wake-ups

Question 2:“How many times do you wake up in a normal night?” Answer choices: 0 to 6 or more times per night.


100%

90%

80%

70%

60%

50%

40%

30%

20%

10%

0%Day 8 Day 30 Day 60 Day 90

% R

epor

ting

a Ch

ange


Change in Self Reported Difficulty Getting to Sleep Compared to Day 0(Extreme Difficulty to Some Difficulty on a Scale from Extreme Difficulty to None)

n = 27

Question 3 Discussion:Evaluating the participants’ ability to fall asleep, 27 said they had some difficulty, a lot of difficulty, or extreme difficulty getting to sleep. The graph above shows a clear switch of participants not noticing much improvement at Day 8 (70%) to those seeing improvements in getting to sleep (63%) by the end of the study.

Prevagen Helps People Get to Sleep

Question 3:“How much difficulty do you have in getting to sleep at night?” Answer choices: Extreme difficulty, A lot, Some, None or Very little.

30%37%

44%52%

59%63%

33%

70%

0%4% 4% 4%

% Reporting Less Difficulty

% Reporting More Difficulty

% No Change

Compared to Day 0


100%

90%

80%

70%

60%

50%

40%

30%

20%

10%

0%Day 8 Day 30 Day 60 Day 90

% R

epor

ting

a Ch

ange


Changes in Sleep for Subjects with Moderate to Poor Sleep at Day 0(Self Reported 1-5 on a 1-10 Scale with 1=Extremely Poor and 10=Excellent)

n = 22

Question 4 Discussion:Twenty-two participants rated themselves between 1 and 5 on a scale of 1 to 10 for overall quality of sleep. This group of poor sleepers represents 40% of the participants in the study and is an indicator of the prevalence of sleep issues in the general adult population. These were generally healthy adults not specifically recruited for their sleep difficulties.

The data shows a fairly rapid response to Prevagen with 68% improving their sleep quality at the first evaluation point at Day 8. The improvement continues at each evaluation point with over 90% seeing an improvement at Day 60 and Day 90.

Prevagen Improves Sleep

Question 4:“How well are you sleeping?” Answer choices: Scale of 1-10 (1=extremely poor, 10=excellent).

68%

86%

95%

52%

9%

91%

32%

0% 0%5%5% 5%5%

% Reporting Reporting Better Sleep % Reporting Worse Sleep% No Change

Compared to Day 0

impact of prevagen on sleep quality - truth in advertising€¦ · 27 participants reported getting...

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