immunotherapies to fight cancer august 2015. 2 01 radiation 02 surgery pillars of cancer treatment...
TRANSCRIPT
Immunotherapies to Fight Cancer
August 2015
2
01RADIATION
02 SURGERY
Pillars of Cancer TreatmentAn overview of cancer therapies
03 CHEMOTHERAPY
04 IMMUNOTHERAPY
MICROENVIRONCAR-T CELLS
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Rings Not Genes
Existing CAR-T Technologies Non-Genetic Biology
Faster. Safer. Cheaper.
5
Status of Tychon Technology
Clinical Candidates Invivo
Study
Results
PSMA
CD-
19
Q32016
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Tychon Current Fundings
SERIES
A
* Currently raised
** Amount depends on strength of current animal
study
SEED
ROUND
$30M** to$10M$1.5M*
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CAR-T TherapyChimeric Antigen Receptor Modified T-Cells
01LEUKAPHERESIS
02 SELECTION
& ACTIVATION
04 CELL EXPANSION
03 GENE TRANSFER
05INFUSION
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Partnership Landscape
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Carston Rick Wagner, Ph.D.
Professor Chair of Medicinal Chemistry
Endowed Chair of Medicinal Chemistry
Director, Chemical Biology Initiative, U of M
Tychon Bioscience, LLC
Danny CunaginCo-Founder & CEO, Invensure, LLC
Founder, Chairman of Board Exosite
Chairman of the Board, Imbio, LLC
Management Consultant, Asombro
Troy Kopischke
Co-Founder & CEO, Invensure, LLC
Co-Founder & CEO, OneOme
Co-Founder, Board Member Exosite
President / CFO, Imbio, LLC
Management Team
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In Girls Last Hope, Altered Immune Cells Beat LeukemiaNew York Times Dec. 9, 2012Desperate to save her, her parents sought an experimental
treatment at the Children’s Hospital of Philadelphia, one that
had never before been tried in a child, or in anyone with the
type of leukemia Emma had. The experiment, in April, used a
disabled form of the virus that causes AIDS to reprogram
Emma’s immune system genetically to kill cancer cells. The
treatment very nearly killed her.
But she emerged from it cancer-free, and about seven
months later is still in complete remission. She is the first
child and one of the first humans ever in whom new
techniques have achieved a long-sought goal — giving a
patient’s own immune system the lasting ability to fight
cancer.
The Promise ofAdoptive T-Cell Therapy
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Contact UsFor More Information
OFFICE
227 Colfax Avenue NorthSuite 148Minneapolis, MN 55405
PHONE
1.612.200.1039
EMAIL / WEBSITE
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Healing is a matter of time, but it is sometimes
also a matter of opportunity.
Hippocrates
EpCam: Breast, Colon Cancer
CD22 & CD19: B-cell Leukemias
EGFR: Ovarian, Brain Cancer
PSMA: Prostate, Brain Cancer
DR5: Pancreatic and Prostate Cancer
CD133 & EpCam: Cancer Ctem Cells
CD16: PAR-Nkcells
CSANs Based Vaccines
PET & MRI Cell Imaging
Our Current Focus