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Immunology9/17/2013 6:28:00 PM

VACCINE

HaemophIlus influenza type Bpolysaccharide capsule conjugated with the protein

The vaccine administered contains the polysaccharide conjugated with diphtheria toxioid

These vaccines protect against SH I N (ENCAPSULATED ORGANISMS) Why are you commonly conjugating to proteins? BECAUSE IN their original form they are not? Vaccines coniaining polypeptide capsule such as (meningococcal vaccine, Pneumovax, H influenza type B are commonly conjugated protein to promote T HELPE

FORMATION OF IMMUNOLOGIC MEMORY

We want to conjugate organisms with proteins so develop memory against them. In order to do so we need to take oraganism which is (conjugated polysacchand as soon as we add a protein to it, the polysaccharide protein combo will become T dependent thus memory can take place in the future

VACCINE TYPES (A) T cell independent

polysaccharide organisms

VACCINE TYPE( B) Protein carriers

Strep Pneumo mutagens non-toxic.DIPTHERIA TOXIN

Neisseria Meningiditides Neisseria meningitides outer

membrane complex

H influenza B tetanus toxin

S H I N are encapsulated bacteria capsules + protein carriers = HAPTENS vaccine = polysaccharide + carrier proteins VACCINE TYPE( B) Protein carriers1. mutagens non-toxic. DIPTHERIA TOXIN

Neisseria meningitides outer membrane complex

2. tetanus toxin or

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