BIAIYK

oSiqifinoro orloHeHra Ha .{ucepralliftny po6ory

€nryruorc ForAanu AHaro.niinrur<<K"rrisirco-reuerr{rt Ha ra eniAervriororiqua xapa KTeprrcrrlKa BpoArr(eHrlx BaA

HeBpaJrbnoi rpy6nu (na vroAe.rri Pisueucrrcoi o6.nacri)>rrpeAcraBlenoi ua:4o6yma Br{eHoro cryrleH.a KaHALI,qara MeAI,ITTHLIX HayK 3a

cneqianrnicrro 03.00.15 - renerl4Ka (rvre4rauni nayrcu)

Arcrya.nrHicrs odpauoi TeMrr. Bi4orvro, ulo rvrafi6yrHe 6yAr-arcoi 4epNann

3HaqHOrO nriporo 3€ure)Kurb sia il TpyAoBofo uoreHqialy, rtt<uit BlI3Haqaerbcf,

craHoM s4opon'x ra MorKJrrrBocrrMLI ni4rnopennx HaceJIeHrIl. Cran e,4opon'x

HaceneHHrr Yrpainu rrpoloBxrye 3aJrlrmatncfl. nesaAosirbHrIM, Irlo pea-ni3yerbc.tt y

ni4'eruuouy upllpocri HaceJreHHs sHacriAox uaAinru HapoAxynanocri, 3pocraHH.a

3axBoproBanocri i crvreprnocri. B en'r:ry 3 IIIIM TILITaHH{ ni4rnopeunx norolinr,HapoAlKeHHr 3AopoBrlx HarrlaArin ua6ynae He JII{Iue oco6ruanoi aKTy€rnbHocri, a fi

Ao3BoJr{e 3aAyMarr{cb npo MoxJrrrBocri nar{ioualuroi 6esnercu naruoi ,qepx(aB}I.

I{e nurraarae AeraJrbHoro analiey ra uu6oKoro BLIBqeHHt qnunuris HerarI,IBHoro

At4TflqOrO HaCeJIeHTUI e BU3HarI€UIbHLIM

crarycy AepxaBI4 i oco6luBo rocrporroKa3Hr{Kovr coqiarbHoro ra eKoHoMi'rHoro

rIlITaHHfl tlocrae ro4i, KoJILI fi4ertcr lpo

BrrJrLrBy, pospo6Itu i sacrocyBaHH.l Aiesux saxoAie npoQilarTlIKI,I.

Ey4r-me 3axBoproBaHHr JrroAr{H?r, 6esnepevHo, Mae BTJII4B na 4o6po6yr iirtaft6nuxrroro ororreHHr - cirvr'i, po.{LIHI4, apysis. Ane icuyrom rari xnopo6z, xlci

Br{3Haqaroru pineur posnurry i 6raroycrporo eciei Aepx(aBLI. Carvre s4opon'r

Ar4Trrry insani,qHicrr. llpupoANeui Ba4vr po3BLITKy e oAnieio 3 ocHoBHnx npI4rILIH

aHTe-, inrpauara-ilrnoi saru6eni uroAa, MarlloKoaoi cueprnocri. Bi.qouo nonaA 4

ruc.sqi szAin rpkIpoAxeHldx Ba,4 po3BrITKy.

3a [a;givr]./Iu Bcecsiruroi opranisauii oxopoHll s4opon'r, rpupoA)KeHa

uaronoris BrnrBJr{erbcfl y 3,0-6,0 o/o wono*apoA)KeHl4x, y 6inuuocri sunaArie - qe

saxKi a6o leralrHi saAH. Y pi:unx rcpaiuax cniry 3a pe3ynbraraMld HarliouzurbHLIx

peecrpin upupo.4Neui BaAr4 po3BlrrKy, rIoKa3HI{KI,I norunpeHHt npogxeHoi

uaronorii cepeA HoBoHapoAxeHHx cyrreBo pi:Hxmcr ra Marorb 3HarIHo lunpmi

vrexi. Ha cr,oroAui oco6lueocri roruupeHHs tlprpoAx{eHrlx BaA po3Bl4rry nnn'reui

HeAocrarHbo, He icnye oAsocrafiuoi 4yrvrxla IrIoAo MoxJILIBI{x Qarcropin pusrary

rrof,BLI IIpI4pOAXeHI4X BaA.

ll{opory n Yrpaini napo4xy€rbcs noHaA 12 ruc. lirefi si cua.qxoeorc i

[pr{pop6eHorc narororiero, ge KoxtHa rr'flTa AlaTrna e inrali4orr,r eHacriAor

npprpoAlKeHrlx BaA po3Br4rKy. flpupo4x{eHa i cuaAKosa naronoris cra6ilrno

3afiMae Apyre rvricqe B crpyKrypi cnrepurocri drefi repluoro poKy )KLIrrt inocryrra€Tbcr rilrrv oKpeMLrM craHaM, xri BI{HVKarorb rlpu HeAoHoluenocri

HoBoHapoAxeHLIX i ualift na:i npu napo4Nenni.

po3BrrrKy,

nenpamnoi

HeBp€LJrbHOl

cupxuonani

3axoAl{,

nacniAr<is

Bagu HeBpaJIbHoi rpy6rcn HaJlexarb Ao rIoHLIpeHrIX npupoAxeHux BaA

B ocHoBHoMy aneHqeQanir ra crILIHHoMo3KoBa KlIJIa. Bagu

rpy6xu e BaroMolo rrpvql{Holo ilepklHaranruot, HeoHarallbHol,

M€rrrroKoBoi ra Aursqoi 3axBoproBasocri i crr,repruocri, a raKor{ ineariAHocri

BrrpoAoB)K ycbofo )KLITT'.

Ar<ryalrrurvr e He rinmu orpI4MaHrul i narpovraAxeHHrl pesynrrarin

AocniAxeHb rrpo BaAu HeBpaJrbHoi rpy6ru, arre ir, eiAuoniAunfi ananis MactIBy AaHlax

3 Meroro posn'xsaHm rrpaKTlrrrHr/D( 3aBAaHb renoreorpaQii, upo$inar<rnxu,

BcraHoBJreHH-f, $arropin prcr.rKy B poAuHax, .ue 3ycrpi.raromcs nonropni BI{[aAKI4

Tlel)K rraToJrofll.

nniHiro-reHerr{qHa ra eni4euionori.IHa xapaKTepucTr4Ka BpoA)KeH}IX BaA

Bi4rar, reMa AlrcepraUifinoi po6oru E.A.eeryruoK, s xrifi po3rJltAaerbcfl

rpy6r<u y PisHeHcrKifi o6nacri ra o6lpyuroByrorbct

Ha B4ocKoH€ureHHq uegu'rrroi AorloMorrl i sNIeHureHH.l

Brrnr{By Hec[prrflTJryrBtrx Qarropin na s4opon'r HaceJIeHHt, e aKTytuIbHoIo ra

cBoeqacHoro.

[ocronipnicrs i o6rpynronanicrb pe3yJrbrarin HayKoBrIx rloJto?Kenn i

nucnonnin. Hayr<oni floJroxreHHf,, BI{cHoBKI{ i peroueuaaqii BIanJII4BaIorb 3

Qarrrvuoro Marepialy i Hocrrb o6'errusuufi xapaKrep, ocrilrru o64pyuronani

pe3ynbraraMlr AocnigxeHr. ,{lr 4ocri.qkeHns 3acrocoBaHo cfracni i a.{ernarsi

MeroAn ananisy. Bzcnosru {pyHTyrorbcf, Ha sHa.rHifi rinrrcocri clocTepex{eHb ra

Ha AocrarHboMy o6crry rniniquux rzuaAris.

!.tts nupiureuHr rrocraBJreHr{x 3aBAaHb AI4cepraHToM BHKopI{craHo

KoMnJreKc aAeKBaTHHX rvrero4in eniAerraiorori.ruzx ra MeALIKo-crarI{crI{rIHI4x

AocriAxenb, a raKox perpeseHrarurl;Huil o6csr Aocli.quoro Marepialy. Bneprue

orpr{MaHo reHerr{Ko-AeMorpaSiuny xapaKreplacrl{Ky uouynrqii PisHeHcrroi

o6racri uoAo rplrpopKeHrlx rla1 po3BkIrKy nenpalrnoi rpy6ru Ha ocuoni

KoMrrJreKcy in$opuaruBHr.rx noKa3HLI Kin, ulo xapaKTepl43yIorb perlpoAyKrusnvrfa

norenqial HaceJreHHr. B Mex(ax xapaKrepr4crtrKu reHerllKo-AeMoqpaQiunoi

crpyKrypri rrorynrqii PinHencrr<oi o6lacri Brleptue upoaualisoeaHi KoJIuBaHH.a

qacrorr4 Ba,{ po3BtrrKy HeBpaluroi rpy6rn sa l5-pivunfi nepioA crlocrepexeHb ra

BcrauoBJreni perionalrni KoHTpacrz ruix nonictr<oro ra He-nonicrKorc rlacruHaMl{

o0Jlacrl.

3Aificreno BLrBrreHHr pinHr iuropnopoBaHofo Cs-137 y narirHlax

PisHeHcrroi o6nacri. Ha ouroni Aocni.{NeHHs sNaicry Qonarin n epnrpoqllrax ra

cr4poBarrli rcponi Ninox penpoAyKrl{BHoro nircy BI{3HatIeHo, Iqo He icuye-tL

AocroBipHoi pisnraqi rraix MerrrKaHKaIun floniccs i ne-lloniccr. Bueprue oqineHo

ni4cyvronani y

o6isHaHicrr xinor PieHeHcrxoi o6racri uloAo upo$inaru{rlHoro 3HaqeHH-fl

Sonienoi KLIoJIoTI4 Ta peKoMeHAoBaHo IlrJlrxu il norpauleHH{.

,{ucepraqifina po6ora E.A.esry[roK Mae rlocJli,qonuufr ra roriqHufi auzartrr

AocniAxenns. fint pea-ni:aqiT Iueru AI,IcepraHroM eupiurynaluc-r .{irro

3aBAaHH.rr, xKI4M eiAuoeiAarorr orpurr,rani pe3yJlbrarl4,

Br.rcHoBKax. .{zcepraHToM AerarlbHo onpallboBana nirepaTypa 3

cSoprvrynnonani

TeMlr AocniANeHH.fl, oco6ncro ni.{i6paHo ra B}IKopucraHo cyracui MeroAtI AJUI

rrpoBeAeHHr reHerr{qHoro anari:y, si6pano senurcufa o6'evr [epB?IHHoro

vrarepiany, Kpt4TLrqHo npoaHali3oBano orpunraHi pe3ynbrarvr ra upeAcraBJleHo

4ani npo BrIpoBaAXeHH.f, ik y nparrnqHy Ai.flmHicrr.

,{zcepraqifina po6ora non'sgaua is BLIKoHaHHTIM uranosoi HayKoBo-

AocliAsurlrroi po6orn <<BzsHa.reHHt reHerI{rIH}IX ocHoB pI{3LIKy po3BIlTKy

uarorori.{Hlrx cranis Ha pirHnx erarlax oHroreHe3y>) 0114U0022I5, repuiH

Br.rKoHaHHr 02.L4-I2.I8 pp., rqo rpoBoALIJIacx ua 'rcaQe4pi iue4Ilunoi ra

la6oparopuoi reHerI,IKLI HMAIIO irvreni n. JI. lllyuura.Honusua ra [parffnrrna gnaquruicrr pery.nsrarin ArIcepralliftnoro

Aoc.rriAxegHfl. Hayrona HoBlr3Ha Allceprauifinoro Aocni.qxeHn.s E. A. enryuor<

Blr3Harlaerbcf, TLrM, IrIo Ha ocnoei AocliAxeHb aBTopoM BcraHoBJIeHo, lqo tlacrora

BaA HeBp€rrrrnoi rpy6r<H y Pinueucrrifi o6nacri e oAniero s Haftsuqux y enpoui i

craHoBr4rr 20,28 ua 10 000 Nzno- i rvreptnoHapoAx{eHllx y nopieHsHHi s cepe4Hirra

roKuI3HI4KoM cepeA qlenin EUROCAT y 20051012 pp.- 9,7 ua 10 000 xnno- i

MeprBoHapoAxteHLIX

,{ucepranroM Br{3HarreHo qI4HHI4KrI pI43LIKy, Iqo cnpllf,Iorb BLIHI{KH€HHrO BaA

HeBp€rJrbHoi rpy6ru - uassHicrb B aHaMnesi cnoHraHHl{x nuruguin, uopx4xonzfi

HoMep naritrocri ra uo.rlorin 4 i 6inrure.

Anroporra elrsereHi ni4rvrinnocri uix Ilonictrrarra ra ne-IIonicbKI{M

periouauu PieueHcrroi o6lacri: qacrora BaA HeBpzulbHoi rpy6r<ra y llonicci

cKJralra 23,4 ua 10 000 xLrBoHapo,qxeHLIX i 6yna gocronipHo BI4IrIorc, nix qacrora

BaA nenpalrnoi rpy6ru y ne-flonicbKoMy perioni 17,5 Ha 10 000

xr{BoHapoA}KeHI4X.

V xo4i Br.rKoHaHHr po6oru BcraHoBJreHo Aocroripuo .Iacriue rroeAHaHHr

BaA HeBpa-irrnoi rpy6rrE 3 neBHrrMI{ Kareropistrlt [pIrpoAxteHLIX na4, oco6JII4Bo 3

BaAaMLr cepe,4unnoi liuii (V 67% suuaAxis MHoxI{HHI{x rIpkIpoAXeHkIX BaA

po3Br{rKy ueeiAor\,roi erionorii y uoe4nanHi s BaAa\rr4 HeBp€IJIbHoi rpy6ru).

AoneAeno, ulo pinui Qolarin B epllrpollurax i cuponaull KpoBl )KlHoK

perrpoAyKrr.rBHoro nir<y n Pinseucmifi o6lacri, xra xapaKTepll3yerbct BI{coKoK)

qacrororo BaA HeBpaluroi rpy6r<u, e rtifiIifi uepio,4 poKy 3HaxoALIJIvrcs' B Mexax

peQepeurHlrx 3Harreur i ue ni4pisHflIrr4cfl, n periouax (p>0,05) s pisuoro qacrorolo

Ba.{ HeBpanbHoi rpy6ru, Iqo cniA.{r.ITb rlpo AocrarHe HaAXo.qx{eHHt Sonarin s

npoAyKTaMu xapqyBanlafl. B qefi ce3oH poKy.

Bzxsreuo HeAocrarHifi pinenr o6isHaHocri xinoK perlpoAyrrznnoro niryPieHeHcrroi o6lacri uloAo npo$inar<rkTqHoro 3HaqeHHt Qonienoi KI4cnorI4 ra

Br,r3HatreHo IIrJItxu if norpauleHHt.

Peaylrraru AocliAxenr ra [paKrr{qHi perouen.qal{ii nnpona,4xeni y

[p aKTuqHy 4ixmni crb MeAkrrrHrrx s arna4ia, MeAI{Ko-f eHerllqHux qenrpin.

Oqinrca nayrconoi ra .nireparypnoi qKocri cKJraAy uarepialy i cru.nro

gucepraqii Ta anropeQepary. .Qrcepraqix EorAarua enryuror HanLIcaHa B

rpa4uqifinifi Sopvri, oQopvrnena siAnoniAuo Ao BLIMoT AAK Yr<painu i szrnaAeHa

sa 123 cropiurax M€lJJrrrHorrr4cHoro reKcry, cKJlaAaerbca is ecrStuy, orJItA/ nireparypz,

orrr4cy vrarepianiB Ta rvrsroAie 4ocrigntenm, pc.qury BJIacHITD( Aocni.Qrenr,

y3arirJrbHeHr{lr, BlrcHonrin, uepeniry BuKopI{c:T€lHI/D( Axepen ra 4 AoAancin. Po6ora

inrocrponana 29 insopvraruBnvrMvr ra6nu1uwtu ra 34 pLIcyHKaMH. Cnucor<

nnropucraHoi lireparypr.r oxorJlloe 218 PKepen' (32 KI4plIJIuqen, 186

nark1Hr{qero). ,{zcepraqifiua po6ora BLIKJIaAeHa y HayKoBoMy cruli rpaMorHoK)

nireparypnoro yrcpaiHcbKoro MoBoro.

y ecryni AlrcepranT o6lpynryBura arryalrnicrr, Mery, 3aB,4aHH.u

AocliAxeHH.f,, Blr3Ha'uvra HayKoBy HoBI{3Hy ra npaKTLIrIHe 3HaqeHH.[ orpuMaHLIX

pe3yJrbrarin, uora.:ata 3r-'fl3oK 3 HayKoBLIMI{ [polpaMaMu i reuaull, oKpecJII{JIa

ocolncruft BHecoK y Br{KoHaHH.rr po6ora ra o6'eu aupo6aqii peeynrrarin

AocniANeHHr y Br{cryrrax i ny6riraqisx sa reMorc Al4ceprallifinoi po6oru.

Our4 nireparypz no6yAosaHuia Ha anarisi rry6nircaqifi sa 4ocniANyBaHoro

reMarr{Koro y cniri. HaneAeso Aani rrpo onuc ra anaris rareropifi BaA HeBpalrnoi

rpy6rn, 3oKpeMa auenqeSalii, inienqeQanii, spina bifida - cilllHHoMosrosoi

Kvrrrv) trepeuHoMosxosoi Kvrrwr enqeQanoqene. HaneAeHo .{aui npo p13H1

$arropn pr43LrKy rroBTopHoro BLTHI4KHeHHI BaA nenpa;lrHoi rpy6ru B olnifi

po4uni. I-{iraeuuz e orrr4c ra anaris AaHr4xpi:nr,rx anropin tuoAo BrInIrBy iouisyrouoi

paaiaqii sr oAniei i: upuuun BlrHlrKHeHruI ilpl4poAlKeHllx BaA po3Bl{rry i, 3oKpeMa,

BaA HeBp€ulrHoi rpy6ru.B pos4ili 2 <Marepialn ra MeroAu AocniAlKeHH.tD) BI4KJIaAeHi ueroAur<n

3acrocoBaHi npu Br4KoHaHHi AocliANeHH.l. 3orpeua, BrrKopllcrani rar<i MeroAI4:

eni.ueuiolori.ruzfi, ruiniro-renealoriqnvfi, vroleKyJlqpHo-reHerl4rlHzfi, intepe'rc,

pa4iorr,rerpii, crarncrl4rlHoro auanisy.

Y pos4ili 3 eraKnaAeni pe3ynbrarr4 BJIacHI4x AocniAxenr, npore qefi

pos4in naAssu.IafiHo posgpi6H esuir- sil 3. 1 .1 Ao 3. 1 .1 1 . Bnaxan, u{o

MoxHa 6yno 6 s1,aeuururz rinrxicu ni4pos4irie Ans KpaIIIoro y3aranbHeHHt

rroAaHlrx pe3yrr6Taris. Y uiapoglini 3.1 asropoM olrl4caHo ra BllBqeno Aasi

o6lacnoro peecrpy lpupoAx{eHux BaA po3BLIrKy 11po 472 B]IITaAKI{ BaA

4

HeBpanbHoi rpy6rra, ei6pannx 3a 2000-2014 pp. 3a craHAapraMl{ ICBDSR

(International Clearinghouse for Birth Defects Surveillance and Research) ra

EUROCAT (European Surveillance of Congenital Anomalies). flpoanali3oBaHo

4ani o6lauroro peecrpy HoBoHapoAXeHI{x npo 232 770 xtl4Bo- iMeprBoHapoAxeHEX lirefi sa 20001014 pp. 3 Merolo uopinnxHHt ce3oHHocri

3arrarb ra Br43HarreHlrx xapaKTepucrr4K sarirHocrefi s naAaMu HeBp€urnoi rpy6ru

ra sarirHocrefi y 3araJrbnifi nonyuqii. V ui4posaini 3.1.2 AerastbHo orucaHe

cnienignorreHHf rraiN crarqMLr (I{:X) cepeA ycix xLIBoHapoAXeHHX lirefiPinuencrrcoi o6lacri sa 2000-2014 pp., sKe KoJITIB€uIocb B Mextax ni4 1,05 Ao I,07,

rrpore HeMae po3paxyHKy rrlo,qo crarncr?I.rHoi pi:Hzqi ruiN lloniccqlul i ue-

floniccsl,r. Cnia ni4snauuru, rrlo rarci po3paxyHKu 6ytu 6 qiranzuu Anfl

rroA€rJrbrur{x rrpkrlyuleHb ra o6rosopeHb na uiAcrasi orp?IMaHI{x pe3ynbraris.

3saxarcqvr:nare)ulo y pe3ynbrari Aanoro AocniAxeHH{ y niapo:4ini 3.1.5 olrl{caHo

,qBa BurraAK?r BaA HeBpzrrrbHoi rpy6ru, mi nacryilvrvr nicls eKcrpaKoplopanbHoro

eanri4neuH.rr, Balr(JrHBr{M e AoHeceHH.t AaHoi iHsopuaqii ao Saxinqin ra xinor,xri rnaHyrorb sariruicrr. Pogdn 3 4o6pe npoimocrponanufi pI4cyHKaMLI ra

AlafpaMaMl4.

3a Aonorvrororc ruinirco-renearori.rHoro MeroAy Bl4BqilIucs oco6wtsocri

perrpoAyKrl{BHoro aHaMHe3y 464 xiHor, sri Hapoilvr:ra Avrrvrry 3 BaAoIo

HeBp€rnbHoi rpy6ru. fiucepraHroM Hane4eni TIpHKTIaAI{ poAonogiB, Ae a o4Hifi

cir,r'i cuocrepiranruafl, Ba;tv po3BI4rKy HeBpanbHoi rpy6rr'r y ABox cu6cin, Ta

noeAHaHH{ MHox{r4HHrdx BaA po3Br4TKy is exa3aHolo BI{IrIe naroloriero.

Orcpivr rlboro, aBropoM Br{BrreHo pinHi inropnopoBaHoro qesirc-l37 cepeg

4795 sarirHux ra rracrory BaA HeBp€uIbHoI rpy6r<r,r y Pinuencrr<ifi o6lacri. 3a

AotroMororo MoneKyJrflpHo-reHerurlHoro Mero.qy uopinnxno reHortlrll4 Niuor

ocnosHoi Ta KoHrpolrHoi rpynr4 sa noriNlopQHxvrn eapiaHravru reHis SonarHoroqurury.

[aHi rpo pinHi Qonarin B epl4rpollllrax ra cLIpoBarIIi rponi xiuorpeilpo4yKrl4BHoro nixy PieHencrroi o6lacri BI{KrIaAeHo y ni4po slifi 3 .2.

llilposlir 3.3. npucv.rrueuuit ananiay o6isHaHocri 224 xinor<

perrpoAyKTlrBHoro nircy PinneHcmoi o6nacri uloAo npo$inanrllqHoro 3HarIeHH.a

Qonienoi KrIcJIorI{.y HacryrlHoMy ni4po:gini 4ucepraHroM oIII4caHa po:po6ra 3axoAiB

npoSirarrurz BaA HeBp€tilbHoi rpy6rcra B PieHeHcrKifr o6nacri Ha oqrosieuiAevrionori'{uzxBrlflBJreHI4X Sarcropin pLT3IaKy, ruisixO-reHeTI4rIHLIX Ta

oco6rtueocrefi.y posgili 4 y3aruurbHeHo pe3ynbrarr{ AocniAxenH-fl Ta rlpoBeAeHo ix

o6ronopeHna siAuoei.qHo Ao ni4oruux AaHvrx lireparypn. fianufi' poe4in

Harr[caHrafi uirro, rpaMorno, qo csiArrlrrb upo Saxosicrr s4o6ynaua HayKoBoI'o

CTYICHIO.

Bncnosru, rtrci :po6neni Al{cepraHrou, ni,4uosiAarom ueri ra 3aBAaHH.ttM

gncepraqii, e o6lpynronani pe3yJlbraraMll AocniAxeHnq

cr arvrcrvruno eiporiAnux Aa:avrx.

I oUL3VIOTbC' Ha

Bianositnicrr anrope$epary svricry qucepraqii: AnropeQepar

nonHicrn siAnosiAae :rr,r i cry Allceprallifi noi po6 oru.

flonnora BrrKJraAy ocHoBHoro suicry 4ncepraqii B onyd.nixoBaHrlx

rrparlflx y HayKoBrrx Qaxonux BrrAaHHflx: 3a p*ynbraraMLI Al4cepraqiftuoipo6oru ouy6liroBaHo 11 naynoBlrx rpal{b, y roMy vucli 3 crarri y Saxonuxnepio4zunux Bvr4aHH.f,x Vrpaiuu, 3arBepAlKeHux MiHicrepcrBoM ocsiru i Hayru

Yrpainu Ans. uy6nircaqii peeyrsrarin Aplcepralliftnrax po6ir, 2 crarri B

rraixnapo4Hlrx HayKoBrrx BLr1arrnflx (European Journal of Medical Genetics, Birth

defects research. Part A, Clinical and molecular teratology), o.qni vretoAur'rHi

perorvren4aqii. Pe:yllrarn po6orz AorosiAarzcs lr'a' 4 HayKoBo-[paKruqHLIX

r<onsepenqixx, B roMy.Iucri aniqi 3a MexaMz Yrpaiuu.llpunquuoBrax 3ayBaxeHr 4o po6oru HeMae, rpoTe B npoqeci ii posrur4y

BIdIJIIKTTVT AetKl 3AfrVrTAHHfl, Ta 3ayBaXeHH-[:

{ucrcycifiHi uo.ttoxeHnfl i sannraunq.1. Hassiu oco6nusocri pelpoAyKTlrBHoro aHaMHe3y xiHor<, y tKkTx

cnocrep ir urucs. nonropn i BI4 rIaAKkI BaA po3BlarKy HeBp€uluroi rpy6rcu.

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