identification of safrole ; precursor...
TRANSCRIPT
Identification of Safrole ; a precursor chemical
Tassaporn Khlaeo-omBureau of Drug and Narcotic
Department of Medical Science, Nonthaburi
What’s Safrole?Safrole is a precursor chemical of
ring-substituted amphetamine-type substances
ex. MDMA or “Ecstasy”MDAMDE
Structure of Safrole
Formula : C10H10O2
Synonym : 3,4-methylenedioxyallylbenzene
5-(2-propenyl)-1,3-benzodioxole
Allyldioxybenzene methylene ether
Physical PropertiesChemical class : aromatic bicyclic phenol etherHabit : colorless to slightly yellow
liquid with an odor of sassafrasSolubility : H2O – insoluble
Propylene glycol- slightly soluble
EtOH, CHCl3, diethyl etherMol Wt. : 162.18 g/molMelting point : 11.2 CBoiling point : 234.5 C at 760 mm Hg
Synthesis from basic and uncontrolledchemical Safrole containing plants :
North AmericaSouth AmericaEast AsiaSouth East Asia
Sources of Safrole
Natural sources - different speciesLauraceae family
( Sassafras albidum, Cinnamomum camphora, Ocotea cymbarum and Ocotea pretiosa)
Piperaceae family( Piper hispidinervium)
Sources of Safrole
ApplicationsFlavoring agent
( drugs, beverages and foods )
Perfume and Soap
Flavor some soft drink ( root beer)
Law Enforcement
Schedule IV under Narcotic Act, B.E. 2522
(ยาเสพตดิใหโทษประเภท 4 (ลําดบัที่ 15) ประกาศกระทรวงสาธารณสุขฉบับที่ 35 (พ.ศ.2539) พระราชบัญญัติยาเสพตดิ
ใหโทษ พ.ศ. 2522)
III. GC SHIMADZU - 2010Column : Agilent, DB-1
(30 m, 0.32 mm id, 0.25 um)Col. temp : initial 100 C-2 min,
rate 20 C/min,final 280 C-5 min
Inj. temp : 250 CDet. temp : 280 CRT (min) : 4.6
Confirmation Test
ConclusionScreening Test :
Color test : Marquis and Gallic acid
Confirmation Test :
UV SpectrophotometryGCGC-MS