icu admission in the obstetric patient

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ICU ADMISSION IN THE OBSTETRIC PATIENT

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ICU ADMISSION IN THE OBSTETRIC PATIENT. Respiratory Physiology. Lung Volumes change second half of pregnancy.  diaphragm  ERV & RV  10-25%  FRC by term  IC,  VC, TLC Airway Function Spirometry normal. Respiratory Physiology 2. - PowerPoint PPT Presentation

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Page 1: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

ICU ADMISSION IN THE OBSTETRIC PATIENT

Page 2: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

Respiratory Physiology

• Lung Volumes• change second half of pregnancy. diaphragm ERV & RV 10-25% FRC by term IC, VC, TLC

• Airway Function

• Spirometry normal

Page 3: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

Respiratory Physiology 2

• Ventilation and Pulmonary Gas Exchange

Vt, Vd, Ve (50%), Va/Ve , Ve/Vo2

• Ve reponse to CO2, hypoxia

• ABG: respiratory alkalosis (pco2 28-30), pH (7.4-7.47), HCO3 18-21.

Page 4: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

Respiratory Physiology 3» Oxygen Transport

• MOTHER• CO increases by 30-50%• maximum by the end of 1/3• supine (3/3): fall (decreased venous return)• VO2 increases 20-33%• Red cell volume increases by 20-30%• Plasma volume increases by 50% • Blood volume increases by 25-50% (79 ml/kg)• Hemodilution..anemia and decrease in COP maximum during 2/3…hemoglobin to 11-12

g/dL

• PREDISPOSED TO• O2 desaturation• PULMONARY EDEMA

Page 5: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

Respiratory Physiology 4» Oxygen Transport

• BABY• placental O2 transport :

Qplacenta = 10% Qmother• fetal factors:• Pao2 (20-30)• Hb (155g/L)• increased O2 affinity of Hbf (Os diss’n curve shifted to the left)• = increased Cao2 (CNS damage with > 75% reduction)• increased CO

• fetus vulnerable to decreases in DO2• startegies to • increase CO, Cao2 (maternal Pao2)

Page 6: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

16 40 0 1 2 WEEKS

FRC

Ve

CO

Blood Vol

GFR

- 20%

+ 40%

+ 40%

+ 40%

+ 50%

Page 7: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

MECHANICAL VENTILATION

• Airway : difficult- Failure to intubate accounts for 47% of all anesthesia-related mortality- 8 X incidence in general surgical population- factors :- hyperemic : oral route- low FRC/O2 reservoir- risk of aspiration (GER/LES, increased Pabd)

- Gas Exchange Pao2 high Pco2 Nal 30 keep <60

- Mechanics Pplateau higher

- PEEP for FRC, but keep up preload

• NIPPV : avoid (see upper airway)

Page 8: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

Acute Respiratory Distress in

the Obstetric Patient: Differential Diagnosis

• VTED

• AFES*

• PET/HTN*

• Tocolytics*

• Aspiration*

• PP Cardiomyop

• Air Embolism*

• Pneumothorax/mediastinum• Other : * can lead to ARDS• ARDS**• Asthma ** sepsis (esp pyelonephritis, PROM,

Pneumonia* antepartum infection), hemorrhagic shock, etc.• Cardiac disease

Page 9: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

ALI/ARDS in

the Obstetric Patient:

• uncommon event, but the most common cause of respiratory failure in the peripartum period.

• incidence 0.2-.3 %

• mortality 43% (Smith West J Med 1990), 10.5% (Karetsky Med 1998)

• risk factors :- cesarian section

- placental abruption

- fetal distress

- dead fetus syndrome

Page 10: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

ALI/ARDS in

the Obstetric Patient 2 • Following Tocolytic Therapy • Low incidence 0-.4%

• Low mortality (<5%)

• onset of dyspnea associated with tachycardia and tachypnea shortly after tocolytic therapy is terminated

• Bilateral pulmonary infiltrates and significant hypoxemia are common findings.

• Resolution within 12-24 hrs of discontinuation. Otherwise, look for other diagnosis

• The etiology of this syndrome is unknown

• had at least 1 other coexisting potential pathogenic mechanism

• accompanying risk factor (maternal or fetal infection,).

Page 11: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

ALI/ARDS in

the Obstetric Patient 3 Pregnancy-induced hypertension• Pulmonary edema rare (2.9%)

• mortality of 10%

• usually accompanied by signs of multisystem organ dysfunction

• pulmonary edema occurred both pre- and postpartum

• proneness to edema…sensitive to fluids

• For both…the role of• Associated risk factors

• Cardiogenic factors

• …remains controversial

Page 12: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

Amniotic Fluid Embolism (AFE)

• classic triad of hypotension, hypoxia, and coagulopathy.

• recognized since 1926• Rare• unique to pregnancy• incidence: 1/8,000- 1/80,000 deliveries• "it is impossible to state the true incidence of this condition at the present

time because the sublethal and even subclinical forms which undoubtedly exist have not been recognized."

– undiagnosed nonfatal cases outnumber the fatal cases– acute cardiopulmonary collapse is not an invariable accompanying finding.– Signs and symptoms may be delayed for many hours postpartum, and most

patients survive even if undiagnosed

Page 13: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

Amniotic Fluid Embolism (AFE)

mortality• 86%

• 25-50% of the patients die within the first hour• the most common cause of peripartum mortality• 5-7% of all maternal deaths • Fetal death is common, but this may be a

consequence of the cardiovascular collapse occurring in the mother

Page 14: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

Amniotic Fluid Embolism (AFE)RISK FACTORS

- age

- multiparity

- uterine stimulants

- uterine rupture

- tumultuousness of labor

- closed abdominal injury

- IUD present at full term

- Amniocentesis

- caesarian section

- placenta accreta

- retained placenta

- meconium-stained amniotic fluid

- complication of amnio-infusion for either a therapeutic instillationor to induce abortion

Page 15: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

Amniotic Fluid Embolism (AFE)

• AF in maternal circulation during pregnancy: physiologic or abnormal ?

• AF: how does it cause for AFES ?

Page 16: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

Amniotic Fluid Embolism (AFE)Clinical Presentation

• May be dramatic, with the abrupt onset of dyspnoea cyanosis, hypotension, coma,and hypotension with rapid progression to cardiopulmonary arrest

• Pulmonary edema (ALI…ARDS) frequent (24-70% of cases), may predominate.

• coagulopathy mild in almost every case

• followed by some degree of consumptive coagulopathy

• Evidence of CNS hypoxia is present, with alterations in mental status progressing to coma. In 10-20% of cases, the patient my present with seizure activity.

• Abruptio

• fetal demise

HEMODYNAMIC PROFILE

Page 17: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

Amniotic Fluid Embolism (AFE)Diagnosis/Treatment

• clinical

• Squames from PAC

• exclude other causes of respiratory distress and hypotension

– septic shock, aspiration pneumonia, uterine rupture, placental abruption, pulmonary thromboembolism, venous air embolism

• Treatment

– Supportive, maintaining DO2, correcting coagulopathy

Page 18: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

Why Mothers die

• The death rate from amniotic fluid embolism could be reduced by avoiding uterine over-stimulation and by prompt diagnosis of obstructed labour

• Rates of obstetric intervention in the form of amniocentesis and induction and augmentation of labour should be kept as low as possible, and research into the condition is still necessary.

Page 19: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

VTED in the OB patient 1

• 2-5/1000 deliveries

• 12% of maternal deaths

• marked increased in the incidence of DVT and PE in the first postpartum month.

• Pregnancy: acquired thrombophilia

• alterations in clotting and fibrinolytic factors

• reduction in venous tone and venous flow from the lower limb

• Other OB factors that enhance the risks for thromboembolism

• Other non-OB risk factors

Page 20: ICU ADMISSION                   IN THE                          OBSTETRIC PATIENT

VTED in the OB patient 2• Diagnosis: similar to the

nonpregnant state

• false-positive test result by bothIPG and duplex ultrasonography.

• Treatment • Prophylaxis • Despite the lack of confirmatory data, the trend has been to treat with

subcutaneous heparin all pregnant women at risk for deep venous thrombosis because of a prior history of deep venous thrombosis, antiphospholipid antibody syndrome, or coagulation inhibitor syndrome.

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