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ECCOMAS:European Communityon Computational Methodsin Applied Sciences

ICBT 2019

4th International Conference onBiomedical Technology

18th – 20th November 2019Hannover, Germany

European Community on Computational Methods in Applied Sciences2

4th International Conference on Biomedical Technology 3

Content

Content

Preface .........................................................................................................................5

Acknowledgements ...............................................................................................6

Organizer and Committees ................................................................................7

Conference Information ........................................................................................9

Program Overview ............................................................................................... 10

Mini Symposia ....................................................................................................... 12

Plenary Lectures ................................................................................................... 11

Scientific Program ................................................................................................ 23

Day 1 ............................................................................................................ 24 Day 2 ............................................................................................................ 28

Day 3 ............................................................................................................ 32

Banquet.................................................................................................................... 34

General Information ............................................................................................ 36


Preface

The IV International Conference on Biomedical Technology will be held in Hannover from 18th to 20th of November 2019. The meeting is organized under the auspices of ECCOMAS, and of the Clusters of Excellence PheonixD and Hearing4All, as well as the Research Center for Medical Implants (NIFE).

Technology meets Medicine

Recent advancements in technology speed up the development of novel tools for supporting diagnostic assessments and the optimization of medical devices for improving clinical approaches. Nevertheless, tailoring of technological developments in Engineering with clinical approaches in Medicine necessitates a thorough understanding of all processes involved and an intensive exchange of information between specialists from diff erent disciplines.

This conference brings together scientists from areas of medicine, engineering, computer and natural sciences. It will focus on the study of living and biological systems, the development and fabrication of new implants, and complications of patient-specifi c medicine.

Hannover, November 2019

Preface

Prof. Prof. h.c. Dr. med.

Thomas LenarzProf. Dr.-Ing. habil. Dr. h.c. mult. Dr.-Ing. E.h.

Peter Wriggers


Acknowledgements

The conference organizers acknowledge the support towards the organization of the ICBT 2019 to the following organizations:

Acknowledgement

Int. Association for Applied Mathematics and Mechanics (GAMM)

Hannover Medical School

Helmholtz

Leibniz Universität Hannover, Germany

European Community on Computational Methods in Applied Sciences (ECCOMAS)

German Association for Computational Mechanics (GACM)


Organizer and Committees

Conference Organizer

Peter Wriggers Institute of Continuum MechanicsLeibniz Universität HannoverAppelstrasse 11, 30167 Hanover - GermanyPhone: +49 511 762 2220Fax: +49 511 762 5496E-mail: [email protected]

Thomas Lenarz Department of OtolaryngologyHannover Medical SchoolCarl-Neuberg-Str. 1, 30625 Hannover - GermanyPhone: +49 511 532 6565Fax: +49 511 532 5558E-mail: [email protected]

Michele MarinoInstitute of Continuum MechanicsLeibniz Universität HannoverAppelstraße 11, 30167 Hannover - GermanyFax: +49 511 762 5496E-mail: [email protected]

Daniela BeyerDepartment of Otolaryngology,Hannover Medical SchoolCarl-Neuberg-Str. 1, 30625 Hannover - GermanyTel. +49 511 532 3016Fax: +49 511 532 5558E-mail: [email protected]

Chair

Co-Chair

Secretary

Congress Office


Organizer and Committees

International Scientific Committee

• José Manuel Garcìa Aznar, University of Zaragoza

• Stephane Avril, Mines Saint-Etienne

• Peter Behrens, Leibniz University Hannover

• Georg Berding, Hannover Medical School

• Andreas Büchner, Hannover Medical School

• Boris Chichkov, Leibniz University Hannover

• T. Christian Gasser, Royal Institute of Technology in Stockholm

• Liesbet Geris, University of Liège and KU Leuven

• Axel Haverich, Hannover Medical School

• Alexander Heisterkamp, Leibniz University Hannover

• Markus Heller, University of Southampton

• Gerhard Holzapfel, Graz University of Technology

• Alexander Huber, University Hospital Zurich

• Christof Hurschler, Hannover Medical School

• Heinrich Lanfermann, Hannover Medical School

• Hannes Maier, Hannover Medical School

• Hans Jünger Maier, Leibniz University Hannover

• Udo Nackenhorst, Leibniz University Hannover

• Waldo Nogueira, Hannover Medical School

• Tobias Ortmaier, Leibniz University Hannover

• Iliana Pepelanova, Leibniz University Hannover

• Andreas Radeloff, Carl von Ossietzky Universität Oldenburg

• Oliver Röhrle, University of Stuttgart

• Thomas Scheper, Leibniz University Hannover

• Ad Snik, Radboud University Nijmegen

• Meike Stiesch, Hannover Medical School

• Paul Watton, University of Sheffield

• Henning Windhagen, Hannover Medical School


Conference Information

Registration

Conference registration will start on Monday, November 18th, at 8 a.m. in the foyer of the Courtyard by Marriot Hotel Hannover Maschsee (Arthur-Menge-Ufer 3, 30169 Hannover)

Presentation: Time & Equipment

Each regular presentation is allocated to 20 minutes and each plenary lecture presentation is allocated to 45 minutes including questions.

So erreichen Sie uns:

Von der Autobahn A7: Abfahrt Hannover Anderten, Südschnellweg (B65),Abfahrt Maschsee /AWD-Arena, rechts ab auf das Rudolf -von-Bennigsen-Ufer, links in das Arthur -Menge-Ufer, das Hotel befindet sich auf derlinken Seite.

Von der Autobahn A2: Abfahrt Hannover Herrenhausen, Leineufer,Westschnellweg / Bremer Damm Richtung Universität, Leibnizufer gera-deaus, rechts in die Culemannstrasse, rechts in das Arthur-Menge-Ufer,das Hotel befindet sich auf der linken Seite.

Generell gilt: Das Hotel finden Sie am Besten, wenn Sie den Schildern„Maschsee“ oder „AWD -Arena“ folgen. Parkplätze sind vorhanden.

Taxi: Vom Hauptbahnhof benötigen Sie 5 -10 Minuten bis zum Hotel,vom Flughafen ca. 20 Minuten.

How to find us:

From the A7 direction Kassel or Hamburg: Exit Hannover Anderten,Südschnellweg (B65), Exit Maschsee / AWD Arena, turn right into Rudolf-von-Bennigsen-Ufer, turn left into Arthur-Menge-Ufer, you will find the hotelon the left hand side.

From the A2 direction Ruhrgebiet: Exit H.-Herrenhausen, Leineufer,Westschnellweg/Bremer Damm direction Universität, Leibnizufer, turnright into Culemannstrasse, turn right into Arthur-Menge-Ufer, you will findthe hotel on the left hand side.

From the A37 direction Celle: Autobahndreieck Misburg, Messe-Schnellweg (A37), Exit Pferdeturm, direction Hannover Zentrum, Hans-Böckler - Allee, turn left into Willy-Brandt-Allee, straight ahead into Arthur-Menge-Ufer, you will find the hotel on the left hand side.

Generally: The easiest way to find us, is to follow the signs “Maschsee”or “AWD Arena”. Parking space is available.

Taxi: You need about 5 -10 minutes from the mainstation to the hotel,from the airport nearly 20 minutes.

Baum Hotelbetrieb Hannover GmbHArthur-Menge-Ufer 330169 Hannover, GermanyPhone +49 (511) 36600 0Fax +49 (511) 36600 555www.courtyardhannover.de

Program


Start End Day 1 Monday 18.11.

Day 2 Tuesday 19.11.

Day 3 Wednesday 20.11.

08:00 Registration

08:45 09:00 Opening

09:00 09:45 Plenary 1 - Goriely Plenary 3 - Melzer

MS 02 MS 05

09:45 10:30 Plenary 2 - Migliavacca Plenary 4 - Geris

10:30 11:00 Coffee break Coffee break Coffee break

11:00 13:20 MS 10 MS 09 MS 10 (Keynote)

MS 08(Keynote)

MS 04 (Keynote) MS 06

13:20 14:30 Lunch Lunch

14:30 16:30 MS 01 (Keynote) MS 07

Plenary 5 - Huber

MS 10 General Session

16:30 17:00 Coffee break Coffee break

17:00 19:00 MS 10 MS 11 MS 01 (Keynote)

General Session

20:00 Social Dinner

Overview

Program


Plenary Lectures

Professor Liesbet GerisEnabling technologies assist advances in regenerative medicine: examples from skeletal tissue engineeringExecutive Director of the Virtual Physiological Human Institute; Tissue Engineering Program Leader of the Skeletal Biology and Engineering Research Center of the KU Leuven; University of Liège and KU Lueven (Belgium)

Professor Alain Goriely Neurodegenerative Diseases and Dementia: Modelling and UnderstandingDirector of the Oxford Centre for Industrial and Applied Mathematics (OCIAM); Director of the International Brain Mechanics and Trauma Lab (IBMTL); Mathematical Institute, University of Oxford (UK)

Professor Alexander HuberBiomechanical challenges to develop a fully implantable cochlear implantDirector Klinik für Ohren-, Nasen-, Hals- und Gesichtschirurgie; University Hospital Zurich (CH)

Professor Andreas MelzerAdvanced Technologies for Image guided InterventionsDirector ICCAS Innovation Center Computer Assisted Surgery, University LeipzigDirector IMSaT Institute for Medical l Science and Technology, University Dundee, UK

Professor Francesco Migliavacca Modelling cardiovascular devices. Towards a personalised medicine?Director Laboratory of Biological Structure Mechanics, Politecnico of Milan (IT)

Program


Mini Symposia

MS 01: Biomechanics and Clinical Demand

MS 02: Preclinical and clinical radiotracer imaging of the hearing system

MS 04: Biodegradable Materials: From Alloy Design to In Vivo Testing

MS 05: 3D Bioprinting: State of art and new emerging trends

MS 06: Drugs and Implants - Masterplan SMART BIOTECS special session

MS 07: Auditory Implants

MS 08: Mechanics of Hearing

MS 09: Clinical relevance and simulation of biological and mechanical influencing factors on dental and biomedical implants

MS 10: Computational Vascular Biomechanics

MS 11: Neural Interfaces

Program


MS 01: Biomechanics and Clinical Demand organized by Udo Nackenhorst, Henning Windhagen, Gerhard A. Holzapfel

The minisymposium addresses latest research activities in theoretical, computational and experimental biomechanics with a focus towards actual questions and needs in clinical practice. Thus, the minisymposium provides an open space for discussions on clinical demands, which are addressed to technical disciplines as well as the latest solution techniques in biomechanics and related fields.

Topics of Interest:

The minisymposium is open for contributions, which address the following items for cells, living tissues, organs and organisms:

• Theoretical, computational and experimental approaches with clinical applications for hard and soft tissues including fluid structure interaction (best practice examples)

• Open questions in the clinical fields and success stories in collaboration between the disciplines

• Novel techniques that open new fields to foster computational biomechanics into clinical applications, e.g. model order reduction, artificial intelligence, data integration etc.

Keynote Speakers:

• Oliver Röhrle, Stuttgart University, Continuum-mechanical Modelling of the Musculoskeletal System

• Nele Famaey, KU Leuven, in vivo, in vitro and in silico modeling of the cardiovascular remodeling phenomena in the Ross procedure

Program


MS 02: Preclinical and clinical radiotracer imaging of the hearing system organized by Georg Berding, Martin Mamach

The pathophysiologic basis of the partly limited restoration of the hearing system after auditory implantation is not sufficiently understood. The suggested mini-symposium focusses on the application of radiotracer imaging as a minimally invasive in vivo approach to gain functional or molecular information for improving the understanding and ultimately the results after implantation. The mini-symposium will give an overview on the subject in two respects: 1. Methods 2. Applications. The following questions will be addressed.

With regard to methods radiopharmaceuticals are a key issue. Which radiotracers are already available to measure processes relevant for hearing (e.g. neuronal activity, transmission or inflammation)? How can effective radiotracer production for use in patients be achieved? In which way are new radiotracers validated? A further aspect is imaging itself. What are the limits of imaging with respect to spatial resolution and contrast recovery – using dedicated scanners for animals or humans? What can be achieved in data analysis e.g. with regard to automated anatomical labeling, statistical parametric mapping and bio-kinetic modelling?

Concerning applications, it will be elaborated first, which animal models are available to study the hearing system and its disorders, e.g. age related hearing loss. Which knowledge acquisition can be obtained based on radiotracer imaging in these animal models? Secondly, the application in humans for precision diagnostics will be elaborated, in particular for the assessment of prognosis and optimization of rehabilitation in connection with auditory implantation.

Topics of interest:

• Radiopharmaceuticals for imaging the hearing system (Tobias Ross)• Quantitative radiotracer studies of the hearing system (Martin Mamach)• Knowledge gain from preclinical radiotracer studies in hearing research

(Mariella Kessler)• Insights from radiotracer studies in auditory implantation (Georg Berding)

Program


MS 04: Biodegradable Materials: From Alloy Design to In Vivo Testing organized by Hans Jürgen Maier, Andrea Meyer-Lindenberg

There is an increasing trend to used absorbable metallic materials in medical applications, as these provide for higher strength than their polymer-based counterparts do. Following extensive basic research, some absorbable alloys are now on the verge to widespread commercial use as well. Still there are substantial challenges in the field. The key issues include tailoring both the mechanical properties and the degradation behaviour to the specific location within the body. Ideally, a biocompatible alloy should fully disintegrate after a given time period without no side effects. Unfortunately, degradation rates determined in in vitro tests typically cannot be used to accurately predict the in vivo behaviour of an actual implant. Clearly, the process of selection of an alloy and design of an implant to prediction of the in-service behaviour and the validation of the properties requires an interdisciplinary approach. The mini-symposium will provide a setting for all those interested in basic aspects and applications of biodegradable materials to discuss. Especially young scientists are encouraged to contribute to the mini-symposium.

Topics of interest:

• Alloy development• Processing• Degradation behaviour• Modelling• In vitro and In vivo testing• Applications

Keynote Speaker:

Prof. Dr. Regine Willumeit-Römer, Helmholtz-Zentrum Geesthacht

Program


MS 05: 3D Bioprinting: State of art and new emerging trends organized by Boris Chichkov, Vladimir Mironov

Rapidly evolving field of 3D bioprinting is a biomedical version of layer by layer additive manufacturing technology. 3D bioprinting could be defined as a robotic additive biofabrication of 3D tissue and organ constructs using biomaterials and living cells according to digital models. The 3D bioprinting technology promises to solve urgent clinical problems of shortage of human tissues and organs for transplantation. It will help to develop new authentic histo- and organotypical models of human diseases and in vitro models for drug discovery and toxicology.

There are three main emerging 3D bioprinting technologies: i) inkjet bioprinting, ii) extrusion-based bioprinting, and iii) laser-based bioprinting. At this symposium, the state of art of these 3D bioprinting technologies will be presented and discussed by leading experts. Special attention will be given to the development of bioincs for 3D bioprinting - one of the hottest research topics in 3D bioprinting. Finally, new research trends in 3D bioprinting, such as hybrid bioprinting, in situ bioprinting, etc. will be discussed.

The symposium will provide comprehensive analysis of 3D bioprinting technologies by outlining new directions in this field including clinical translation and commercialisation aspects.

Program


MS 06: Drugs and Implantsorganized by Masterplan SMART BIOTECS consortium

In this symposium, researchers from SMART BIOTECS will showcase their work in the area of bioactive substances and intelligent implant design. SMART BIOTECS is a collaborative research consortium between the Leibniz University of Hannover and the Technical University of Braunschweig. Researchers from both universities have joined forces in a strategic alliance which combines the unique but complementary expertise of both locations. Focus of their joint activities includes the research of next-generation drugs for infectious and degenerative diseases, as well as the development of novel implant technologies with integrated sensors and improved biofunctionality. The mini-symposium gives a unique perspective into the current biomedical research landscape of two of Lower Saxony’s leading technical universities

Program


MS 07: Auditory Implantsorganized by Thomas Lenarz

Auditory Implants have undergone rapid development over the last three decades. Today they offer a wide spectrum for auditory rehabilitation for all types and grades of hearing loss. Future developments are directing towards advanced implants with added biological components such as drugs, cells and nano particles. The aim at restoring and modulating the cochlear environment is for hearing preservation and regeneration. Adding sensors and recording electrodes along the auditory pathway, these implants will become closed loop systems for automated adaptation to the special acoustic environment will be able to sense early biological changes at the tissue interface and by using artificial intelligence will self-optimize the auditory performance in recipients.

The symposium will provide a comprehensive overview on state of the art and recent developments.

Program


MS 08: Mechanics of Hearingorganized by Hannes Maier

Program


MS 09: Clinical relevance and simulation of biological and mechanical influencing factors on dental and biomedical implantsorganized by Andreas Greuling, Meike Stiesch

In modern medicine implant treatment, e.g. dental implants or orthopedic implants are frequently used in multifarious indications. Many patients suffer from tooth decay or even tooth loss which requires dental treatment.

Several factors can influence the long term success of medical and dental implants: bone quantity and quality, biofilm formation, mechanical loading, type of implant system, prosthetic construction tissue-integration and anchorage. For sustainable restorations, one should keep these factors in mind, which can have a significant impact on biomechanical properties and long term prognosis of implants.

In this context in silico studies can speed up research and development for medical implants and/or restorative solutions, and can also address topics which are too complex to be studied solely by means of physical experiments. This mini-symposium aims to bring together scientists from various communities in order to develop new interdisciplinary strategies for the improvement in the long term success of medical implants and restorations.

Topics of Interest:

The topics to be discussed in the mini-symposium include:

• Ceramic materials and their medical use• FE-simulation of different ceramic materials depending on their indication• Dental implants – case reports, indications and limitations• FE-simulation of loaded dental implants correlated to the design of the

suprastructure• In vitro systems of oral biofilms• Numerical simulations of biofilm development

Keywords: In silico studies, Biofilms, Ceramics, Implants, Dentistry

Program


MS 10: Computational Vascular Biomechanics organized by T. Christian Gasser, Stephane Avril

Simulations of the vascular mechanical system and its interaction with the biological processes can advance the understanding of physiological and pathological mechanisms and may open a door to the development of new treatment options and medical devices. Mechanical concepts are challenged by quite a few aspects when applied to problems that incorporate living tissue material and in vivo patient specific geometries: There usually exist a large uncertainty and variation in material properties, difficulties in length-scale separation, a lack of access to samples for experimental testing, a clear definition of a reference frame, difficulties in geometry capturing and the mechano-biochemical interplay, just to name a few. Towards building trust and applicability of computational models to real world clinical questions and problems, such challenges need to be addressed.

Topics of Interest:

Therefore, this minisymposium focuses on aspects, such as:

• Uncertainty quantification and large patient cohorts• Inverse methods and parameter identification• Reduced order models of clinical relevance• Patient-specific constitutive modeling• Multifield methods in a patient-specific context• Multiscale methods applied to real world problems• Integrated imaging & computation approaches• Development and validation of boundary conditions• Real-time computational mechanics.

Keynote Speaker:

Karol Miller, University of Western Australia, Towards simple, compatible with clinical workflows patient-specific computational vascular biomechanics

Program


MS 11: Neural Interfacesorganized by Waldo Nogueira, Andreas Büchner

Recent advances in engineering, computing and neuroscience are contributing to novel approaches to recover human senses and to treat neurological and mental disorders as well as understanding various function of the brain. These new approaches are based on the ability to stimulate and record neural activity with increased accuracy. New technologies including stimulation and recording devices as well as computational models permit the expansion and understanding of neural interfaces, devices that interact with the nervous system to restore or enable sensory and motor function. Examples of successful neural interfaces include cochlear implants for hearing impaired people, retinal implants for the blind, and devices for deep brain stimulation (DBS) for individuals with Parkinson’s disease, essential tremor and other motor symptoms. This session will include review studies and novel contributions in the field of retinal, cochlear and central auditory implants, deep brain stimulation implants as well as cortical stimulation and recording devices. Bringing researchers together from different disciplines working in different applications will bring synergistic effects and offer the opportunity to learn from each other’s field. Computational models may include:

• Electrical and mechanical stimulation through neuroprosthetics• Neural activity recording and modeling• Higher level perceptual models of hearing, vision and motor function• Personalization of neural prosthetics• Optimization of neural prosthetics based on computation models

Program


Scientific Program

The scope of the conference is

• Biomaterials, biocompatibility and infections• Tissue and organs in health and disease• Biofabrication and cell behavior• Imaging and diagnostic tools• Design and fabrication of new implants• Technologies for drug delivery• Experiments and models in bioengineering• Patient-specific biomedical technology• Robotics for surgery• In silico Medicine


Program Monday, 18th November 2019 - Day 1

Monday, 18th November 2019

08:00 Registration Venue: Courtyard Hotel

08:45-09:00 Opening Venue: Salon 5

Plenary lectures Venue: Salon 5

09:00-09:45 Neurodegenerative Diseases and Dementia: Modelling and Understanding Alain Goriely

09:45-10:30 Modelling cardiovascular devices. Towards a personalised medicine? Francesco Migliavacca

10:30-11:00 Coffee break

MS 10: Computational Vascular Biomechanics organized by T. Christian Gasser, Stephane Avril Venue: Salon 5

11:00-11:20 Modelling the inelastic time-dependant mechanical properties of collagenous soft tissues Christopher Miller, T. Christian Gasser

11:20-11:40 Simulation of healing in damaged soft tissues based on gradient- enhance continuum models Yiqian He, Di Zuo, Haitian Yang, Klaus Hackl, S Jamaleddin Mousavi and Stéphane Avril

11:40-12:00 A Continuum Model for Soft Biological Tissues: Collagen Damage Coupled with Growth and Remodeling Meike Gierig, Michele Marino, Peter Wriggers

12:00-12:20 Biomechanical alterations in ascending thoracic aortic aneurysms with varying aortic valve morphology Raja Jayendiran, Salvatore Campisi, Magali Viallon, Pierre Croisille, Stéphane Avril

12:20-12:40 Growth and remodeling of an idealized artery with an endofibrosis pathology Jérome Jansen, Xavier Escriva and Fabien Godeferd

12:40-13:00 A Machine Learning Material Model for Heart Valve Simulations Michael S. Sacks, Wenbo Zhang



MS 09: Clinical relevance and simulation of biological and me-chanical influencing factors on dental and biomedical implants organized by Andreas Greuling, Meike Stiesch Venue: Salon 6

11:00-11:20 Biochemical functionalization of ceramic surfaces for improved tissue integration of medical implants Alena Palkowitz, Frederik Boke, Taskin Tuna, Shaza Bishti, Stefan Wolfart, Horst Fischer

11:20-11:40 The influence of occlusal loading in simulations of tooth stress response during biting Oliver Rohrle, Saini Harnoor, Leo K Cheng, David C. Ackland

11:40-12:00 Dental implants – case reports, indications and limitations Philipp-Cornelius Pott, Michael Eisenburger, Meike Stiesch

12:00-12:20 Influence of the material stiffness of the framework material on the biomechanical behaviour of a full bridge on four implants Christoph Bourauel, Ludger Keilig, Arozo Ahmadi

12:20-12:40 In vitro Models of Bacterial Biofilms Katharina Doll, Nadine Kommerein, Henryke Grünberg (née Rath), Dinalei Feng, Nico S. Stumpp, Insa Neuweiler, Udo Nackenhorst, Meike Stiesch

12:40-13:00 Anisotropic growth driven by nutrient diffusion: theory, FEM implementation and an application to the biofilm growth Meisam Soleimani, Peter Wriggers

13:00-13:20 Mesoscale modelling of dimethacrylate-based materials: From an atomistic monomer melt to a coarse-grained polymer Lauritz T. Bußfeld, Peter Behrens, Andreas M. Schneider

13:20-14:30 Lunch

MS 01: Biomechanics and Clinical Demandorganized by Udo Nackenhorst, Henning Windhagen, Gerhard A. Holzapfel Venue: Salon 5

14:30-15:10 Keynote: Continuum-mechanical Modelling of the Musculoskeletal System Oliver Rohrle, Christian Bleiler, Thomas Klotz

15:10-15:30 Towards full automation of predictive bone simulation: blending voxel finite elements with robust variational segmentation Dominik Schillinger, Tarun Gangwar, Lam H. Nguyen



15:30-15:50 Patient-specific Mechanical Properties Assignment onto CT-based Bone Geometry Models Amadeus Alcantara, Konrad Mehle, Wolf-Dietrich Knoll, Stefan Schwan, Munir Skaf, Paulo Sollero 15:50-16:10 A parametic approach to the biomechanical compatibility of hip joint endoprostheses Maximilian Bittens, Udo Nackenhorst 16:10-16:30 The Influence of Binder Mobility to the Viral Entry Driven by the Receptor Diffusion S. Klinge, T. Wiegold, R. P. Gilbert, G. A. Holzapfel

MS 07: Auditory Implantsorganized by Thomas Lenarz Venue: Salon 6

14:30-14:50 Intraoperative Monitoring Andreas Radeloff 14:50-15:10 Optogenetic cochlear implant Tobias Moser

15:10-15:30 Bone anchored hearing aids Ad Snik

15:30-15:50 Fully implantable hearing aid Susen Lailach 15:50-16:10 Central auditory implants Thomas Lenarz


MS 10: Computational Vascular Biomechanics organized by T. Christian Gasser, Stephane Avril Venue: Salon 5

17:00-17:20 A Coupled Control Model of a Pneumatic Heart Assist Device, Heart and Circulatory System Robert Wohlfarth, Michael W. Gee, Stephen M. Wildhirt

17:20-17:40 Comparative study of the principal strain lines in the left ventricle J. Ivan Colorado-Cervantes, Vittorio Sansalone, Paolo Piras, Luciano Teresi



17:40-18:00 Modelling blood flow and molecular transport in the cerebral micro- circulation: impact of capillary occlusions in Alzheimer’s disease Maxime Berg, Yohan Davit, Michel Quintard, Sylvie Lorthois

18:00-18:20 Structural determinants of transport in complex microvascular networks Igor Chernyavsky, Alexander Erlich, Philip Pearce, Gareth Nye, Paul Brownbill, Romina Plitman Mayo, Oliver Jensen

18:20-18:40 Towards a multiscale model of metastatic liver cancer Etienne Jessen, Adnan Ebrahem, Dominik Schillinger MS 11: Neural Interfaces organized by Waldo Nogueira, Andreas Büchner Venue: Salon 6 17:00-17:20 DBS for animal models of Parkinson‘s disease - a preclinical testbed for electroceuticals to come Ulrich G. Hofmann, Soheil Mottaghi

17:20-17:40 Retinal Implants Karsten Hufendiek, Carsten Framme

17:40-18:00 Clinical investigation of a novel central auditory prosthesis: The two- shank Auditory Midbrain Implant Karl-Heinz Dyballa, Waldo Nogueira, Amir Samii, Hussam Metwali, Rolf Salcher, Max Timm, Angelika Illg, Alexandros Giourgas, Reinhard Dengler, Colette McKay, Hubert Lim, Thomas Lenarz 18:00-18:20 Enhancement of Interaural Level Differences and Binaural Band Selection Improves Sound Localization in Bilateral Cochlear Implant Users Tom Gajecki, Waldo Nogueira

18:20-18:40 A Computational Model of Electric-Acoustic Stimulation in Cochlear Implant Subjects with Residual Hearing Daniel Alrutz, Waldo Nogueira 18:40-19:00 Implantable multiplexing system for ECoG using biocompatible technology Juan Pablo Marcoleta, Waldo Nogueira, Theodor Doll


Program Tuesday ,19th November 2019 - Day 2


Plenary lectures Venue: Salon 5

09:00-09:45 Advanced Technologies for Image guided Interventions Andreas Melzer

09:45-10:30 Enabling technologies assist advances in regenerative medicine: examples from skeletal tissue engineering Liesbet Geris

10:30-11:00 Coffee break MS 10: Computational Vascular Biomechanics organized by T. Christian Gasser, Stephane Avril Venue: Salon 5

11:00-11:40 Keynote: Towards simple, compatible with clinical workflows patient- specific computational vascular biomechanics Karol Miller

11:40-12:00 Geodesics and the Vasculature: an Investigation on the Impact of Geometry on Aortic Constitutive Models Vittoria Flamini, Yijie Li

12:00-12:20 Computational modelling of growth and remodelling in human ascending thoracic aneurysms Stéphane Avril, Jamal Mousavi, Joan Laubrie

12:20-12:40 Real-time contact dynamics for endovascular procedures simulation using corotational beams and discrete signed distance fields Miquel Aguirre, Stéphane Avril 12:40-13:00 Computional estimation of annual risk of rupture for abdominal aortic aneurysm Stanislav Polzer, Jan Kracik, Tomáš Novotný, Lubos Kubicek, Robert Staffa, Madhavan L. Raghavan

13:00-13:20 Next generation parameter calibration: including boundary conditions stresses and preloads. Heleen Fehervary, Klaas Vander Linden, Julie Vastmans, Lauranne Maes, Nele Famaey

Tuesday, 19th November 2019



MS 08: Mechanics of Hearingorganized by Hannes Maier Venue: Salon 6

11:00-11:20 Computational Modeling and Biomechanical Measurement of Blast Wave Transmission through the Ear Rong Z. Gan

11:20-11:40 Neuronal Excitation Patterns from a High-Resolution Model of the Cochlea Werner Hemmert, Jorg Encke, Richard Bachmaier, Frank Bohnke, Siwei Bai 11:40-12:00 Parametric amplification of traveling waves in the cochlea Frank Bohnke

12:00-12:20 Consequences of ear surgery on bone conducted sound S. Prodanovic, S. Stenfelt 12:20-12:40 Sound wave propagation on bone conduction hearing: coupling dependence Tahmine S. Farahmandi, Ivo Dobrev, Alexander M. Huber, Christof Roosli

12:40-13:00 Methods and reference data for middle ear transfer functions Martin Koch, Till Moritz Eßinger, Hannes Maier, Ingo Roder, Marcus Neudert, Thomas Zahnert, Matthias Bornitz

13:20-14:30 Lunch

Plenary lecture Venue: Salon 5

14:30-15:10 Biomechanical challenges to develop a fully implantable cochlear implant Alexander Huber

MS 10: Computational Vascular Biomechanics organized by T. Christian Gasser, Stephane Avril Venue: Salon 5 15:30-15:50 Particle tracking in the carotid circulation to estimate risk of Amaurosis Fugax Rodrigo M. Romarowski, Matteo Stochino, Ferdinando Auricchio, T. Christian Gasser, Antti Siika, Ulf Hedin, Michele Conti

15:50-16:10 Patient Specific Model of Carotid Artery Bifurcation with Atheroma Ondřej Lisický, Jiří Burša



16:10-16:30 Mechanical Predictors of Plaque Rupture in Atherosclerotic Arteries Ali Akyildiz, Daniel Rutten, Frank Gijsen

General Sessionchairman: tba Venue: Salon 6

15:30-15:50 Development and research of nanostructured materials as components of drug delivery systems E.V. Dmitrienko, E.N. Bobrikova, V.K. Fomenko, D.V. Pyshnyi

15:50-16:10 Single mismatch detection and discrimination using DNA-metal bonds Chanho Park, Yeongeun Yu, Sungsoo Na 16:10-16:30 Sensor performance Enhancement via surface modification using Nanostructure and Carbon nanotube Seonwoo Lee, Chanho Park, Sungsoo Na


MS 01: Biomechanics and Clinical Demandorganized by Udo Nackenhorst, Henning Windhagen, Gerhard A. Holzapfel Venue: Salon 5

17:00-17:40 Keynote: In vivo, in vitro and in silico modeling of cardiovascular remodeling phenomena in the Ross procedure Nele Famaey, Julie Vastmans, Emma Vanderveken, Lauranne Maes, Filip Rega 17:40-18:00 On the computational modeling of bioengineered soft collagenous tissue for the use in biohybrid aortic valve implants Lukas Lamm, Deepanshu Sodhani, Stefanie Reese, Stefan Jockenhovel 18:00-18:20 Novel Phenomenological Equations for Myocardial Contraction Baris Cansiz, Lucas A. Woodworth, Michael Kaliske

18:20-18:40 Image-based silulation of the mitral valve repair surgery in ischemic mitral regurgitation patients Michael S. Sacks, Amir Khalighi, and Bruno Rego



General Session chairman: tba Venue: Salon 6

17:00-17:20 Flow in brain aneurysms: CFD simulations and 4D flow MRI measurements Augusto F. Sanches, Daniel S. Nasato

17:20-17:40 Virtual Surgeries of Nasal Cavities Using a Coupled Lattice- Boltzmann-Level-Set Approach Moritz Waldmann, Andreas Lintermann, Wolfgang Schroder

17:40-18:00 Three-Dimensional CFD Analysis of Upper Human Airway Sandra Nafuna Wanyonyi, Dilek Funda Kurtulus, M. Kürsat Gokcan

18:00-18:20 Towards Uncertainty Calibration in Computer-aided Diagnosis with Deep Learning for Patient Safety Max-Heinrich Laves, Sontje Ihler, Tobias Ortmaier

18:20-18:40 Towards Patient-Specific Neural Networks for Image-Based Motion Estimation Sontje Ihler, Max-Heinrich Laves, Lüder A. Kahrs, Tobias Ortmaier

20:00 Social Dinner


Program Wednesday, 20th November 2019 - Day 3


MS 02: Preclinical and clinical radiotracer imaging of the hearing systemorganized by Georg Berding, Martin Mamach Venue: Salon 5

09:00-09:20 Radiopharmaceuticals for imaging the hearing system Tobias L. Ross, Mariella Kessler, Martin Mamach, Georg Berding

09:20-09:40 Quantitative radiotracer studies of the hearing system Martin Mamach, Mariella Kessler, Georg Berding 09:40-10:00 Knowledge gain from preclinical radiotracer studies in hearing research Mariella Kessler, Martin Mamach, Georg Berding

10:00-10:20 Insights from radiotracer studies in auditory implantation Georg Berding, Mariella Kessler , Martin Mamach

MS 05: 3D Bioprinting: State of art and new emerging trendsorganized by Boris Chichkov, Vladimir Mironov Venue: Salon 6

09:00-09:20 New materials and strategies for extrusion bioprinting Michael Gelinsky 09:20-09:40 Laser-based Cell Printing for Tissue Engineering Lothar Koch, Andrea Deiwick, Boris Chichkov 09:40-10:00 Laser structuring of titanium dental implants for biocompatibility improving Galina Odintsova, Yulia Karlagina, Elena Egorova, Tatiana Itina and Vadim Veiko, Catherine Zernitskaia , Gennady Chernenko

10:00-10:20 Recent progress in Bioprinting Vladimir Mironov


MS 04: Biodegradable Materials: From Alloy Design to In Vivo Testingorganized by Hans Jürgen Maier, Andrea Meyer-Lindenberg Venue: Salon 5

Wednesday, 20th November 2019


Program Wednesday, 20th November 2019 - Day 3

11:00-11:40 Keynote: Mg-alloys for Biomedical Applications Regine Willumeit-Romer 11:40-12:00 Magnesium Sponges as Resorbable Bone Implants Manufactured by Investment Casting S. Julmi, A.-K. Gartzke, A.-C. Waselau, A. Meyer-Lindenberg, P. Wriggers, C. Klose, H.J. Maier

12:00-12:20 Tough core, degradable surface: zirconia and bioglasses acting together to improve the biocompatibility of dental implants Claudia Fleck

12:20-12:40 Coupled computational implant degradation and bone ingrowth model Ann-Kathrin Gartzke, Stefan Julmi, Christian Klose, Silke Besdo, Anja-Christina Waselau, Andrea Meyer-Lindenberg, Hans Jürgen Maier, Peter Wriggers

12:40-13:00 Preclinical in vivo evaluation of degradable magnesium implants in suitable animal models Janin Reifenrath

13:00-13:20 In vivo results of osseointegration and degradation behaviour of porous Mg- based scaffolds F. Feichtner, N. Kleer, J. Augustin, L. Witting, A.-C. Waselau, S. Julmi, A.-K. Gartzke, C. Klose, H.J. Maier, P. Wriggers, A. Meyer-Lindenberg

MS 06: Drugs and Implants organized by Masterplan SMART BIOTECS consortium - Chairman: Cornelia Blume Venue: Salon 6

11:00-11:20 Gold Organometallics in Medicinal Chemistry Ingo Ott

11:20-11:40 Generation of a Biohybrid Vascular Structure X. Kraus, F. Cholewa, S. Heene, S. Loewner, S. Thoms, N. Stanislawski, H. Blume, C. Blume 11:40-12:00 Computational methods for the design of bioprinting protocols: challenges and opportunities Michele Marino, Aidin Hajikhani, Peter Wriggers

12:00-12:20 Multiphysics modelling of chemomechanically smart hydrogels Aidin Hajikhani, Michele Marino, Peter Wriggers

13:20 End of conference and farewell

Program


Banquet

Program


Tuesday, 19th November 2019

20:00 Bahlsen Steam Machine Hall at Novotel

The ICBT 2019 is a guest in the architecturally award-winning Novotel Hannover. Here the present meets history, because the hotel is integrated into the historical setting of the former Bahlsen biscuit factory. We see the imposing historic steam engines and enjoy a sumptuous dinner.

Shuttel Service will be provided!

Venue: Novotel HannoverPodbielskistraße 2130163 HannoverPhone: +49 (0) 511 39040

Old Bahlsen Building: Figures „Brezelmänner“ by Georg Herting with the Leibniz biscuit, which was stolen in January 2013 and brought back in February 2013.

Historic steam machines at Novotel Hannover


General Information


Venue

Hannover, one of the greenest cities in Europe, has a long historical tradition. The capital of Lower Saxony, with around 500,000 inhabitants, has many attractions such as the royal baroque gardens in Herrenhausen (winner of the European Garden Award 2015), the Maschsee Lake, the Hannover Adventure Zoo and the Eilenriede city forest, Hannover‘s ‘green lung‘.

There are also a number of museums dedicated to modern art and design, as well as cultural institutions exploring Hannover‘s historical background, including the Gottfried Wilhelm Leibniz library. Hannover is a friendly city with many pubs, a car-free historic center and numerous shopping facilities.

The Leibniz Universität Hannover is one of Germany‘s TU9 universities. Hannover is also home of the Hannover Medical School and the University of Veterinary Medicine. Hannover can boast a thriving scientifi c community.

Discover Hannover

Congress offi ceDaniela Beyermobile + 49 (0) 176 26 09 28 28

Tourist Information Tel.: + 49 (0) 511 / 123 45-111www.hannover.de

TaxiTel.: + 49 (0) 511 / 38 11www.taxi-hannover.de

Airport Hannover www.hannover-airport.de

Hannover Main Station www.bahn.de

UESTRA Public Transportwww.uestra.de

Useful numbers

• Hannover´s taxi drivers do not acceptcredit cards!

• Currency in Germany is € (Euro).• Germany Time: Central European

Winter Time (CEST) = GMT + 1• Power supply: In Germany the power

sockets are of type F. This socket also works with plug C and plug E.


Venue

Shaping the Future with Knowledge – as one of the nine leading Institutes of Technology in Germany, Leibniz University is aware of its responsibility in seeking sustainable, peaceful and responsible solutions to the key issues of tomorrow.Our expertise for this stems from the broad spectrum of subjects, ranging from engineering and natural sciences to architecture and environmental planning, from law and economics to social sciences and humanities.

At Leibniz University there are currently almost 30,000 students studying in nine faculties, and some 3,100 researchers working in more than 180 institutes. The main building of the university is the Royal Palace Welfenschloss at the Welfengarten. Our internationally visible core research topics are in mechanical engineering, in quantum optics and gravitational physics, in biomedical research and in teacher training. The broad range of subjects at Leibniz University is entirely compatible with an overall university strategy of raising its profile, in particular of teaching and research, including the establishment and enhancement of research priority areas originating in the humanities and social sciences. Cooperation agreements with national and international partners strengthen our scientific expertise – our most important partner is Hannover Medical School (MHH). By adopting the name of the polymath Gottfried Wilhelm Leibniz in 2006, the university committed itself to unity in its diversity.

Leibniz Universität Hannover


Venue

Hannover Medical School

The Department of Otorhinolaryngology at Hannover Medical School (MHH) is internationally renowned for hosting the world’s largest cochlear implant (CI) programme to treat severely hearing impaired patients. To date, more than 10,000 people have received a CI here. One of our priority areas, therefore, is provision of hearing systems – from the development of the devices themselves to lifelong support for our patients. Together, the German Hearing Center Hannover and the scientific laboratories form the joint platform for these activities.Other priority areas include hearing-aid fitting (and improving this process), the early identification of hearing loss in children, diagnosis and treatment of inner-ear diseases including tinnitus, skull base surgery including treatment of acoustic neu¬roma, tumour surgery using modern laser surgical and endoscopic techniques, di¬seases of the nose and sinuses, covering allergology, environmental medicine and plastic/reconstructive techniques.Our Department has six wards with a total of 90 beds. Each year we treat around 25,000 outpatients and just under 6,000 inpatients. A highly motivated and specialised team is available, with more than 200 staff – including 30 doctors, 20 nurses, nine education professionals and speech therapists, 20 technical staff and 30 scientists.Our case numbers: more than 600 cochlear implants, 85 middle-ear implants and 100 acoustic neuromas in 2018.

A nationwide first at MHH’s ENT Department: in autumn 2011, for the first time in Germany (and only the fourth time in the world) a patient was successfully implanted with MED-EL’s new ‘bone bridge’ system. In 2015 we were the first in Germany to implant successfully the first Oticon Medical CI.

Edited by

Peter WriggersLeibniz Universität Hannover, Germany

Thomas LenarzHannover Medical School MHH, Germany

Congress Office

Daniela BeyerDepartment of OtolaryngologyHannover Medical SchoolCarl-Neuberg-Str. 1, 30625 Hannover - GermanyPhone: +49 (0) 511 532 3016 Cell Phone: +49 (0) 176 1532 3936Fax: +49 (0) 511 532 5558E-mail: [email protected]

http://www.icbt19.uni-hannover.de/

icbt 2019 program€¦ · program eccomas: european community on computational methods in applied...

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